GO:0045715

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Name negative regulation of low-density lipoprotein particle receptor biosynthetic process
Categary Process
Go Slim No
Go Link GO:0045715
Unique Molecular Interactions 98
Total Molecular Interactions 133
Total Single Events 1289
Pain Genes Associated 4

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of low-density lipoprotein particle receptor biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of low-density lipoprotein particle receptor biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT83428 Binding of ADIPOQ and FRTS 3 0.18 2.02 1.19
2 INT240619 Binding of CRP and ADIPOQ 8 0.18 10.74 0.78
3 INT83424 Binding of CD40LG and ADIPOQ 2 0.13 1 0.59
4 INT83426 ADIPOQ Negative_regulation of Binding of CD40LG 2 0.21 1 0.59
5 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
6 INT83423 ADIPOQ Negative_regulation of Binding of IGHG3 1 0.02 0.31 0.42
7 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
8 INT296945 ADIPOQ Negative_regulation of TNF 1 0.03 1.13 0.4
9 INT240617 Binding of APOB and ADIPOQ 1 0.04 3.62 0.38
10 INT240616 Binding of SHBG and ADIPOQ 1 0.31 4.43 0.37
11 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
12 INT240626 Binding of ADIPOQ and Hdlcl1 1 0.02 3.27 0.28
13 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23
14 INT179492 Binding of Ins1 and Adipoq 1 0.16 1.16 0.23
15 INT249760 Positive_regulation of Cnr1 Negative_regulation of Gene_expression of Adipoq 1 0.20 0.81 0.22
16 INT260397 Positive_regulation of Hmox1 Positive_regulation of Gene_expression of Adipoq 1 0.37 0.78 0.22
17 INT242996 Adipoq Negative_regulation of Transcription of Cd68 1 0.22 0.6 0.21
18 INT242994 Adipoq Negative_regulation of Spp1 1 0.19 0.59 0.21
19 INT332304 Binding of Il6 and Adipoq 1 0.03 0.4 0.2
20 INT145886 Binding of CXCL1 and Adipoq 1 0.00 0.77 0.2
21 INT352518 Binding of FAT1 and Adipoq 1 0.01 2.79 0.2
22 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19
23 INT260394 Positive_regulation of Hmox1 Positive_regulation of Adipoq 1 0.37 0.78 0.19
24 INT334394 ADIPOQ Negative_regulation of Gene_expression of Tnf 1 0.37 1.06 0.18
25 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18
26 INT228168 Adipoq Positive_regulation of Prkag1 2 0.05 1.08 0.17
27 INT240622 Binding of ADIPOQ and Etv3 1 0.04 1.32 0.15
28 INT157275 Binding of PRKAA1 and Adipoq 1 0.01 1.13 0.15
29 INT157273 Adipoq Positive_regulation of PRKAA1 1 0.03 1.16 0.14
30 INT270663 Adipoq Positive_regulation of Il6 1 0.02 1.05 0.12
31 INT179493 Adipoq Positive_regulation of Ins1 1 0.20 0.99 0.12
32 INT270669 Adipoq Positive_regulation of IL8 1 0.01 1.06 0.12
33 INT150532 LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
34 INT150533 Positive_regulation of LEP Negative_regulation of Adipoq 1 0.00 1.34 0.12
35 INT270665 Adipoq Positive_regulation of Ccl2 1 0.07 1.06 0.12
36 INT164746 Binding of LEP and Adipoq 1 0.07 0.69 0.12
37 INT228175 RNU1-1 Regulation of Adipoq 1 0.11 0.78 0.12
38 INT257467 Fat1 Regulation of Gene_expression of Adipoq 1 0.08 0.56 0.11
39 INT240624 Binding of ADIPOQ and Hdl1 1 0.02 0.85 0.1
40 INT262996 ADIPOQ Regulation of INS 1 0.13 1.25 0.1
41 INT310275 Negative_regulation of Binding of Adipoq and Ins1 1 0.19 1.14 0.09
42 INT157276 PPARG Positive_regulation of Adipoq 1 0.29 1.09 0.09
43 INT157274 Adipoq Positive_regulation of ADIPOR1 1 0.00 1.2 0.09
44 INT310274 Binding of Adipoq and Ins1 1 0.21 1.14 0.09
45 INT228174 RNU1-1 Positive_regulation of Gene_expression of Adipoq 1 0.12 0.55 0.08
46 INT257466 Psd Negative_regulation of Gene_expression of Adipoq 1 0.22 0.66 0.08
47 INT267154 ADIPOQ Regulation of Positive_regulation of SUGT1 1 0.03 1.18 0.08
48 INT352517 Binding of INS and Adipoq 1 0.09 1.32 0.07
49 INT262997 Binding of HSD11B1 and ADIPOQ 1 0.54 2.82 0.07
50 INT260392 Hmox1 Positive_regulation of Adipoq 1 0.32 0.65 0.07
51 INT336380 Gene_expression of Adipoq Positive_regulation of Ppara 1 0.06 1.77 0.07
52 INT140813 Binding of Retn and Adipoq 1 0.03 1.18 0.06
53 INT267157 LEP Positive_regulation of ADIPOQ 1 0.10 0.51 0.05
54 INT217666 ADIPOQ Regulation of Gene_expression of INS 1 0.03 1.99 0.05
55 INT228169 Gm2733 Regulation of Adipoq 1 0.00 0.51 0.05
56 INT228591 Adipoq Positive_regulation of Phosphorylation of Prkaa2 1 0.31 0.61 0.04
57 INT236590 Binding of Adipoq and Ncoa2 1 0.15 0.2 0.03
58 INT236587 Binding of Adipoq and Ncoa1 1 0.17 0.2 0.03
59 INT314370 Adipoq Positive_regulation of Tnfrsf11a 1 0.04 1.26 0.03
60 INT236592 Positive_regulation of Binding of Adipoq and Ncoa2 1 0.19 0.2 0.03
61 INT227305 Zbp1 Regulation of Gene_expression of Adipoq 1 0.21 1.27 0
62 INT204323 Binding of ADIPOQ and Negative_regulation of Gene_expression of ROS1 1 0.08 0.12 0
63 INT233267 Hoxa10 Regulation of Itgb3 1 0.15 0.14 0
64 INT352516 Binding of POMT1 and Adipoq 1 0.01 0.4 0
65 INT204322 Binding of ADIPOQ and Positive_regulation of Gene_expression of PPARGC1A 1 0.30 0.07 0
66 INT260395 Positive_regulation of Adipoq Negative_regulation of Gene_expression of Hmox1 1 0.34 1.4 0
67 INT140814 Adipoq Regulation of Retn 1 0.03 0.8 0
68 INT227302 Zbp1 Regulation of Transcription of Adipoq 1 0.09 1.27 0
69 INT313502 Binding of ALOX5AP and ADIPOQ 1 0.05 0.44 0
70 INT350254 Slc12a6 Regulation of Gene_expression of Adipoq 1 0.02 0.63 0
71 INT197915 Des Positive_regulation of Adipoq 1 0.07 0 0
72 INT332943 Binding of SNRNP70 and Adipoq 1 0.00 1.35 0
73 INT353062 HSD11B1 Regulation of Gene_expression of ADIPOQ 1 0.13 5.03 0
74 INT233270 Meis1 Regulation of Gene_expression of Itgb3 1 0.47 0 0
75 INT325283 Negative_regulation of MCL1 Positive_regulation of Gene_expression of ADIPOQ 1 0.14 1.53 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of low-density lipoprotein particle receptor biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of low-density lipoprotein particle receptor biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT117500 Gene_expression of Adipoq 90 0.74 67.79 16.58
2 INT26975 Gene_expression of Adipoq 113 0.75 106.71 14.46
3 INT117502 Positive_regulation of Adipoq 70 0.63 40.43 12.03
4 INT125136 Regulation of Adipoq 24 0.56 16.82 7.23
5 INT137454 Gene_expression of ADIPOQ 88 0.78 85.32 6.2
6 INT146043 Positive_regulation of Gene_expression of Adipoq 39 0.67 29.93 6.12
7 INT117499 Negative_regulation of Adipoq 28 0.56 24.15 5.07
8 INT83431 Binding of ADIPOQ 35 0.48 33.63 3.83
9 INT83433 Positive_regulation of ADIPOQ 40 0.69 34 3.67
10 INT28021 Positive_regulation of Adipoq 42 0.67 30.79 3.58
11 INT117501 Positive_regulation of Gene_expression of Adipoq 24 0.63 12.99 3.1
12 INT204340 Localization of ADIPOQ 20 0.75 25.18 2.64
13 INT26974 Negative_regulation of Adipoq 27 0.52 26.01 2.59
14 INT111451 Regulation of ADIPOQ 24 0.56 18.81 2.47
15 INT122561 Negative_regulation of Gene_expression of Adipoq 12 0.56 14.02 2.26
16 INT135451 Positive_regulation of Positive_regulation of Adipoq 3 0.40 2.06 2.24
17 INT138029 Binding of Adipoq 10 0.40 6.81 2.04
18 INT134633 Localization of Adipoq 9 0.60 6.39 2.03
19 INT227273 Localization of Adipoq 22 0.72 18.04 1.72
20 INT188241 Negative_regulation of ADIPOQ 16 0.43 22.16 1.47
21 INT227275 Negative_regulation of Gene_expression of Adipoq 19 0.53 19.51 1.15
22 INT213277 Positive_regulation of Gene_expression of ADIPOQ 14 0.50 17.7 1.14
23 INT160140 Regulation of Binding of Adipoq 1 0.37 0.87 0.92
24 INT227270 Regulation of Gene_expression of Adipoq 5 0.55 7.35 0.85
25 INT151927 Regulation of Gene_expression of Adipoq 3 0.43 3.32 0.81
26 INT142013 Positive_regulation of Regulation of Adipoq 1 0.03 0.65 0.78
27 INT28020 Binding of Adipoq 10 0.36 11.49 0.77
28 INT148756 Regulation of Adipoq 10 0.60 7.83 0.67
29 INT118310 Negative_regulation of Positive_regulation of Adipoq 2 0.34 2.47 0.61
30 INT179488 Positive_regulation of Transcription of Adipoq 3 0.37 0.5 0.6
31 INT227272 Transcription of Adipoq 8 0.64 8.29 0.49
32 INT83430 Positive_regulation of Binding of ADIPOQ 2 0.21 0.85 0.49
33 INT83434 Negative_regulation of Binding of ADIPOQ 1 0.39 1.14 0.45
34 INT308980 Positive_regulation of Negative_regulation of Adipoq 3 0.33 2.3 0.4
35 INT179491 Transcription of Adipoq 4 0.51 0.98 0.32
36 INT227268 Negative_regulation of Transcription of Adipoq 4 0.52 4.93 0.3
37 INT125780 Negative_regulation of Itgb3 2 0.39 0.66 0.25
38 INT253941 Positive_regulation of Localization of Adipoq 5 0.24 2.59 0.21
39 INT91278 Positive_regulation of Itgb3 4 0.31 1.73 0.19
40 INT150529 Positive_regulation of Negative_regulation of Adipoq 2 0.37 1.76 0.18
41 INT197872 Regulation of Regulation of Adipoq 3 0.35 1.11 0.17
42 INT233246 Localization of Itgb3 3 0.54 0.25 0.17
43 INT239859 Protein_catabolism of Itgb3 1 0.64 0.25 0.17
44 INT28026 Positive_regulation of Binding of Adipoq 1 0.27 0 0.17
45 INT137455 Protein_catabolism of ADIPOQ 1 0.66 0.25 0.17
46 INT228162 Negative_regulation of Localization of Adipoq 1 0.38 1.29 0.17
47 INT308978 Negative_regulation of Regulation of Adipoq 1 0.28 0.92 0.17
48 INT263001 Regulation of Gene_expression of ADIPOQ 5 0.45 3.77 0.16
49 INT163262 Transcription of ADIPOQ 5 0.52 2.81 0.14
50 INT262999 Negative_regulation of Gene_expression of ADIPOQ 7 0.43 9.52 0.12
51 INT233217 Gene_expression of Itgb3 16 0.75 0.98 0.11
52 INT157267 Negative_regulation of Localization of Adipoq 1 0.24 0.94 0.09
53 INT327816 Regulation of Positive_regulation of ADIPOQ 1 0.04 1.2 0.09
54 INT233253 Regulation of Gene_expression of Itgb3 1 0.41 0.34 0.09
55 INT353069 Positive_regulation of Positive_regulation of ADIPOQ 1 0.13 1.75 0.05
56 INT245905 Negative_regulation of Transcription of ADIPOQ 1 0.42 1.26 0.05
57 INT228584 Phosphorylation of Adipoq 1 0.38 0.61 0.04
58 INT251940 Positive_regulation of Transcription of ADIPOQ 1 0.01 0 0.04
59 INT219663 Binding of Itgb3 1 0.08 1.18 0.03
60 INT240621 Negative_regulation of Localization of ADIPOQ 1 0.39 0.64 0.03
61 INT233234 Negative_regulation of Gene_expression of Itgb3 3 0.29 0.65 0
62 INT233231 Regulation of Transcription of Itgb3 1 0.30 0.12 0
63 INT233238 Negative_regulation of Localization of Itgb3 1 0.29 0 0
64 INT257464 Negative_regulation of Transcription of Adipoq 1 0.41 0.45 0
65 INT263530 Negative_regulation of Positive_regulation of ADIPOQ 1 0.31 1.43 0
66 INT233251 Regulation of Localization of Itgb3 1 0.30 0 0
67 INT227262 Regulation of Transcription of Adipoq 1 0.35 0.47 0
68 INT233240 Negative_regulation of Transcription of Itgb3 1 0.29 0 0
69 INT233257 Transcription of Itgb3 1 0.48 0.11 0
70 INT233227 Positive_regulation of Transcription of Itgb3 1 0.47 0.12 0
71 INT233228 Regulation of Itgb3 1 0.30 0 0
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