GO:0045736

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Name negative regulation of cyclin-dependent protein kinase activity
Categary Process
Go Slim No
Go Link GO:0045736
Unique Molecular Interactions 395
Total Molecular Interactions 516
Total Single Events 5817
Pain Genes Associated 22

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cyclin-dependent protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of cyclin-dependent protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
2 INT155891 Nps Negative_regulation of Positive_regulation of Casp3 1 0.27 0.17 3.48
3 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35
4 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26
5 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25
6 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19
7 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
8 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
9 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54
10 INT137657 Gorasp2 Regulation of Binding of Casp3 1 0.09 0 1.52
11 INT83707 Acyp2-ps1 Regulation of Casp3 1 0.17 0 1.28
12 INT83705 Acyp2-ps1 Regulation of Positive_regulation of Casp3 1 0.17 0 1.28
13 INT113844 CDKN1A Negative_regulation of CDK2 4 0.49 1.18 1.27
14 INT84886 APC Regulation of PPARD 1 0.51 1.57 1.26
15 INT145315 D2Mit212 Regulation of Casp3 1 0.00 0 1.24
16 INT162163 CDKN2A Positive_regulation of PLD2 1 0.24 0 1.24
17 INT145316 D2Mit212 Regulation of Positive_regulation of Casp3 1 0.00 0 1.24
18 INT145317 D2Mit212 Positive_regulation of Casp3 1 0.01 0 1.22
19 INT93435 Binding of Casp3 and Cckbr 1 0.06 0.15 1.18
20 INT155892 Nps Negative_regulation of Casp3 1 0.27 0.06 1.16
21 INT155890 Nps Negative_regulation of Gene_expression of Casp3 1 0.27 0.05 1.15
22 INT112607 DNAJC15 Negative_regulation of Positive_regulation of Casp3 1 0.03 0.14 1.12
23 INT159235 H2-M3 Negative_regulation of Casp3 1 0.05 0 1.12
24 INT159236 H2-M3 Positive_regulation of Casp3 1 0.06 0 1.12
25 INT155894 Nps Regulation of Gene_expression of Casp3 1 0.33 0.07 1.09
26 INT74460 GTS Negative_regulation of Casp3 1 0.04 0.37 1.08
27 INT159237 Gpm6a Positive_regulation of Casp3 1 0.03 0 1.07
28 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
29 INT225158 Binding of CDK2 and CDKN1A 7 0.30 3.26 1.02
30 INT98556 Oprm1 Positive_regulation of Casp3 1 0.38 0.36 1.01
31 INT98180 Aap Positive_regulation of Positive_regulation of Casp3 1 0.00 1.08 0.97
32 INT155893 Nps Regulation of Casp3 1 0.24 0.08 0.95
33 INT220031 Casp3 Positive_regulation of Gene_expression of Nos3 1 0.04 0 0.92
34 INT92404 PSRC1 Regulation of CDKN1A 1 0.33 0.66 0.89
35 INT148806 Diablo Positive_regulation of Positive_regulation of Casp3 1 0.03 1.02 0.89
36 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88
37 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 0.01 0.29 0.85
38 INT116250 Vta1 Positive_regulation of Casp3 1 0.01 0 0.82
39 INT56236 Casp3 Positive_regulation of Gene_expression of RT1-Cl 1 0.00 0.45 0.82
40 INT307044 Tmie Regulation of Casp3 1 0.01 0 0.75
41 INT195778 Binding of APC and PROCR 7 0.19 3.78 0.73
42 INT114860 Negative_regulation of Insrr Positive_regulation of Casp3 1 0.02 0.71 0.73
43 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
44 INT151559 Atp2a1 Negative_regulation of Positive_regulation of CASP3 1 0.06 0.68 0.66
45 INT129694 Binding of Casp3 and Casp9 1 0.35 0.86 0.65
46 INT351445 Binding of Vta1 and Positive_regulation of Casp3 1 0.01 0.39 0.64
47 INT106754 Pes1 Positive_regulation of Casp3 1 0.13 0 0.63
48 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 0.12 0 0.63
49 INT11558 POMC Positive_regulation of CASP3 1 0.05 0 0.62
50 INT166398 CDKN1B Regulation of Gene_expression of CDKN1A 1 0.46 0.83 0.61
51 INT83706 Acyp2-ps1 Positive_regulation of Casp3 1 0.11 0 0.61
52 INT166399 CDKN1A Regulation of Gene_expression of CDKN1B 1 0.46 0.83 0.61
53 INT166395 CDKN1A Regulation of Gene_expression of IFI27 1 0.32 0.83 0.61
54 INT166402 CDKN1A Regulation of Gene_expression of TP53 1 0.27 0.83 0.61
55 INT166392 IFI27 Regulation of Gene_expression of CDKN1A 1 0.32 0.83 0.61
56 INT92403 PSRC1 Regulation of Positive_regulation of CDKN1A 1 0.33 0.45 0.6
57 INT114505 Negative_regulation of Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
58 INT114506 Hmmr Positive_regulation of Casp3 1 0.01 0.72 0.6
59 INT133320 Penk Negative_regulation of Gene_expression of Casp3 1 0.11 0.91 0.6
60 INT163376 RYBP Positive_regulation of Gene_expression of Casp3 2 0.01 0.57 0.59
61 INT112399 Olr897-ps Regulation of Gene_expression of Casp3 1 0.03 0 0.54
62 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
63 INT74517 Binding of Casp3 and Cnrip1 1 0.31 0 0.51
64 INT234609 Binding of CASP3 and IMMT 1 0.00 0.5 0.5
65 INT182150 Binding of APC and DCPS 1 0.02 1.14 0.48
66 INT114297 Apc Negative_regulation of Gene_expression of Fcer2a 1 0.03 0.96 0.48
67 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47
68 INT307048 Cnr1 Positive_regulation of Casp3 1 0.08 0 0.47
69 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45
70 INT57236 Casp3 Positive_regulation of Prl 1 0.09 0 0.41
71 INT158032 Binding of CDKN2A and KRT20 1 0.28 0.59 0.4
72 INT57235 Casp3 Positive_regulation of Localization of Prl 1 0.15 0 0.4
73 INT337890 Per1 Regulation of Nr2f2 1 0.08 0 0.37
74 INT52960 Casp3 Negative_regulation of Positive_regulation of Ltp 1 0.02 0 0.37
75 INT84887 APC Negative_regulation of Gene_expression of PPARD 1 0.36 0.55 0.37
76 INT145908 Pdyn Regulation of Positive_regulation of Casp3 1 0.14 0.94 0.37
77 INT204071 HP Positive_regulation of Gene_expression of CDKN2A 1 0.00 3.48 0.34
78 INT130803 MC1R Regulation of Positive_regulation of Cdkn2a 1 0.17 0.82 0.34
79 INT119262 PPM1E Negative_regulation of Positive_regulation of CDKN1A 1 0.01 0.96 0.33
80 INT263978 Binding of ADRB2 and TNFAIP3 1 0.01 0.5 0.32
81 INT195665 APC Negative_regulation of F8 1 0.04 1.53 0.32
82 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32
83 INT166394 CDKN1B Regulation of Gene_expression of TP53 1 0.28 0.41 0.31
84 INT166391 IFI27 Regulation of Gene_expression of CDKN1B 1 0.33 0.41 0.31
85 INT286708 Negative_regulation of Mapk1 Negative_regulation of Casp3 1 0.12 0 0.31
86 INT220521 Ugt1a6b Positive_regulation of Cdkn1b 1 0.01 2.38 0.31
87 INT195664 APC Negative_regulation of F5 1 0.08 1.51 0.31
88 INT166397 CDKN1B Regulation of Gene_expression of IFI27 1 0.33 0.41 0.31
89 INT63122 Binding of APC and Man2a2 1 0.01 0.15 0.3
90 INT166162 Ccr9 Negative_regulation of Positive_regulation of Casp3 1 0.18 1.49 0.28
91 INT289954 Binding of APC and CD28 1 0.03 0.38 0.28
92 INT172977 Cdkn1a Negative_regulation of Positive_regulation of Inca1 1 0.00 1.39 0.27
93 INT96788 Binding of SP3 and NR2F2 1 0.24 0.27 0.27
94 INT96789 Binding of SP1 and NR2F2 1 0.24 0.27 0.27
95 INT350813 Binding of Apc and Crp 1 0.18 1.12 0.27
96 INT337884 Ins1 Negative_regulation of Gene_expression of Nr2f2 1 0.11 0.08 0.27
97 INT337896 Ins1 Negative_regulation of Nr2f2 1 0.15 0.1 0.27
98 INT148629 Binding of Cat and Casp3 1 0.08 0.09 0.26
99 INT147593 Binding of CDK4 and CDKN2A 1 0.42 0.23 0.26
100 INT172975 Trp53 Positive_regulation of Cdkn1a 1 0.03 1.35 0.26
101 INT147592 Positive_regulation of Binding of CDK4 and CDKN2A 1 0.44 0.23 0.26
102 INT225160 Negative_regulation of Binding of CDK2 and CDKN1A 1 0.35 0 0.25
103 INT121249 Binding of ANXA5 and CASP3 1 0.36 0.67 0.25
104 INT149713 Binding of Casp3 and Fas 1 0.40 1.09 0.25
105 INT235976 Binding of APC and Trav6-3 2 0.01 2.62 0.24
106 INT235974 Negative_regulation of Binding of APC and Trav6-3 1 0.00 1.15 0.24
107 INT235972 Negative_regulation of Binding of APC and Bcr 1 0.01 1.15 0.24
108 INT235973 Binding of APC and Bcr 1 0.01 1.14 0.24
109 INT171049 Binding of FAS and Positive_regulation of Gene_expression of CASP3 1 0.04 1.41 0.24
110 INT337892 Positive_regulation of Mc4r Positive_regulation of Gene_expression of Nr2f2 1 0.34 0 0.23
111 INT109408 Negative_regulation of APC Negative_regulation of Positive_regulation of RASGRP1 1 0.06 0.73 0.23
112 INT245555 Runx1 Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
113 INT250783 APC Negative_regulation of SERPINE1 1 0.06 0.86 0.23
114 INT245565 Runx1 Negative_regulation of Negative_regulation of Cdkn1a 1 0.29 1.17 0.23
115 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
116 INT316111 APC Negative_regulation of SAE1 1 0.04 1.21 0.22
117 INT289998 CNTF Negative_regulation of Casp3 1 0.04 0.99 0.22
118 INT289981 Cntf Negative_regulation of Casp3 1 0.02 1.01 0.22
119 INT349344 Bdnf Negative_regulation of Casp3 1 0.13 0.96 0.22
120 INT289999 Binding of CNTF and Casp3 1 0.04 0.99 0.22
121 INT195663 APC Negative_regulation of Gene_expression of IL6 1 0.16 1.18 0.22
122 INT181675 Positive_regulation of Casp9 Positive_regulation of Casp3 1 0.06 0.51 0.2
123 INT315384 Adcyap1 Negative_regulation of Positive_regulation of Casp3 1 0.02 0.53 0.2
124 INT316110 Binding of APC and SAE1 1 0.03 1.16 0.2
125 INT322543 Binding of FOXO3 and Cdkn1b 1 0.08 0.84 0.19
126 INT181677 Casp9 Positive_regulation of Casp3 1 0.06 0.5 0.19
127 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19
128 INT212084 NOXO1 Positive_regulation of CDKN1A 1 0.06 0.53 0.19
129 INT192219 CASP3 Regulation of ESR1 1 0.03 1.19 0.19
130 INT351442 Gria2 Regulation of Gene_expression of Casp3 1 0.01 0 0.18
131 INT275400 Casp3 Positive_regulation of NDRG1 1 0.00 1.36 0.18
132 INT334106 APC Negative_regulation of NFKB1 1 0.25 1.37 0.17
133 INT334108 APC Negative_regulation of TNF 1 0.13 1.36 0.17
134 INT96416 CYC1 Positive_regulation of Casp3 1 0.02 0.96 0.17
135 INT119263 Binding of CDKN1A and PPM1E 1 0.01 0.46 0.17
136 INT149095 PITX2 Positive_regulation of Casp3 1 0.00 1.51 0.15
137 INT136855 Arf5 Positive_regulation of Cdkn2a 1 0.07 1.8 0.15
138 INT337894 Ins1 Regulation of Gene_expression of Nr2f2 1 0.07 0.22 0.15
139 INT292748 Akt1 Negative_regulation of Positive_regulation of Casp3 1 0.01 1.81 0.15
140 INT314856 Binding of Cdc7 and Cdkn2a 1 0.28 1.34 0.14
141 INT302146 CDKN2A Regulation of CDKN1B 1 0.11 0.51 0.14
142 INT123192 Bmp6 Positive_regulation of CDKN1A 1 0.18 0.61 0.14
143 INT96791 NR2F2 Positive_regulation of GDF15 1 0.23 0.14 0.14
144 INT302144 CDKN2A Regulation of CDKN1A 1 0.11 0.51 0.14
145 INT226205 Negative_regulation of Akt1 Positive_regulation of Casp3 1 0.04 0.71 0.14
146 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
147 INT193789 SDF2L1 Positive_regulation of CDKN1A 1 0.00 0.68 0.13
148 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
149 INT242163 Wnt2 Positive_regulation of Regulation of Apc 1 0.13 0.71 0.13
150 INT275397 Binding of ITIH4 and Casp3 1 0.02 0.64 0.13
151 INT193785 SDF2L1 Positive_regulation of Gene_expression of CDKN1A 1 0.00 0.68 0.13
152 INT252631 Binding of Casp3 and Tnfrsf1a 1 0.10 0.69 0.13
153 INT275389 Binding of Casp3 and Htatsf1 1 0.00 0.64 0.13
154 INT184603 APC Negative_regulation of Gene_expression of TNF 1 0.09 0.97 0.13
155 INT252632 Binding of Casp3 and Tradd 1 0.11 0.68 0.12
156 INT349345 Bdnf Negative_regulation of Positive_regulation of Casp3 1 0.13 1.02 0.12
157 INT316190 Apc Negative_regulation of Positive_regulation of Mapk1 1 0.33 0.66 0.12
158 INT201754 CASP8 Positive_regulation of Casp3 1 0.00 0.47 0.12
159 INT315391 IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
160 INT184608 APC Regulation of Gene_expression of Nppa 1 0.06 1.11 0.12
161 INT315390 Positive_regulation of IFNA1 Positive_regulation of Casp3 1 0.00 0.1 0.12
162 INT299754 Binding of APC and CTLA4 2 0.08 0.97 0.11
163 INT142961 Binding of Nfkb1 and Casp3 1 0.00 1.02 0.11
164 INT234062 Nes Positive_regulation of Casp3 1 0.18 0.08 0.11
165 INT285023 Casp3 Negative_regulation of Casp7 1 0.07 0.44 0.1
166 INT262255 Binding of APC and F2R 1 0.05 3 0.1
167 INT233858 CHKA Positive_regulation of Gene_expression of CDKN1B 1 0.10 0.17 0.09
168 INT237922 TNFSF10 Positive_regulation of CDKN1A 1 0.09 3.28 0.08
169 INT302178 CDKN1C Regulation of CDKN2A 1 0.09 0.26 0.08
170 INT337898 Positive_regulation of MC3R Regulation of Gene_expression of Nr2f2 1 0.30 0 0.08
171 INT270203 Binding of CD28 and Apc 1 0.04 0.58 0.08
172 INT302158 CDKN1A Regulation of CDKN2A 1 0.04 0.26 0.08
173 INT136856 Cdkn2a Positive_regulation of Arf5 1 0.01 0.9 0.08
174 INT302139 LAMTOR1 Regulation of CDKN2A 1 0.08 0.26 0.08
175 INT270197 Binding of Apc and Cd86 1 0.02 0.58 0.08
176 INT302157 MRPL28 Regulation of CDKN2A 1 0.09 0.26 0.08
177 INT220514 Ppara Positive_regulation of Gene_expression of Cdkn1b 1 0.08 1 0.08
178 INT302148 IFI27 Regulation of CDKN2A 1 0.11 0.26 0.08
179 INT270198 Binding of Apc and Cd80 1 0.02 0.58 0.08
180 INT258021 Positive_regulation of Binding of CDK2 and CDKN1A 1 0.11 0.84 0.07
181 INT193783 ITIH4 Regulation of Gene_expression of CDKN1A 1 0.03 0.55 0.07
182 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
183 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
184 INT203849 Ass1 Positive_regulation of Casp3 1 0.00 0.71 0.07
185 INT302160 LAMTOR1 Regulation of CDKN1A 1 0.08 0.26 0.06
186 INT302150 MRPL28 Regulation of CDKN1B 1 0.09 0.26 0.06
187 INT175966 Kctd1 Negative_regulation of Positive_regulation of CASP3 1 0.09 0.82 0.06
188 INT302143 TP53 Regulation of Positive_regulation of CASP3 1 0.01 0.69 0.06
189 INT302129 BAX Regulation of Positive_regulation of CASP3 1 0.02 0.69 0.06
190 INT204074 Tp53 Positive_regulation of Cdkn1b 1 0.00 0.59 0.06
191 INT302136 LAMTOR1 Regulation of CDKN1B 1 0.08 0.26 0.06
192 INT302127 MRPL28 Regulation of CDKN1A 1 0.09 0.26 0.06
193 INT257879 Negative_regulation of Eif4e Positive_regulation of Cdkn1b 1 0.28 0.54 0.06
194 INT344254 Binding of PARP1 and CASP3 1 0.06 0.94 0.06
195 INT211347 Binding of Sigmar1 and Positive_regulation of Casp3 1 0.12 0.92 0.06
196 INT176095 Binding of Apc and EC 1 0.04 0.51 0.05
197 INT204079 HP Positive_regulation of Gene_expression of Cdkn1b 1 0.00 0.6 0.05
198 INT302133 IFI27 Regulation of CDKN1B 1 0.11 0.26 0.05
199 INT302130 CDKN1A Regulation of CDKN1B 1 0.04 0.26 0.05
200 INT302176 CDKN1C Regulation of CDKN1A 1 0.09 0.26 0.05

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of cyclin-dependent protein kinase activity. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of cyclin-dependent protein kinase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07
2 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03
3 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68
4 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43
5 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92
6 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78
7 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63
8 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38
9 INT65597 Negative_regulation of Casp3 69 0.59 39.19 29.32
10 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59
11 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77
12 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7
13 INT29704 Regulation of Casp3 51 0.56 22.13 22.79
14 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62
15 INT28215 Gene_expression of CDKN1A 196 0.76 113.9 18.3
16 INT22547 Regulation of Gene_expression of Casp3 23 0.62 8.04 16.78
17 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2
18 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16
19 INT75502 Positive_regulation of CDKN1A 123 0.68 70.75 14.74
20 INT94774 Regulation of CDKN2A 43 0.60 44.41 13.99
21 INT78472 Gene_expression of CDKN2A 223 0.78 173.76 13.61
22 INT81626 Positive_regulation of Positive_regulation of Casp3 34 0.69 16.75 12.18
23 INT78695 Regulation of Casp3 24 0.44 9.43 10.48
24 INT29705 Regulation of Positive_regulation of Casp3 13 0.48 5.37 10.45
25 INT62269 Gene_expression of Cdkn1a 60 0.73 35.78 9.84
26 INT57162 Positive_regulation of Gene_expression of CDKN1A 64 0.68 35.3 9.69
27 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22
28 INT57057 Gene_expression of APC 131 0.78 122.24 8.7
29 INT78696 Regulation of Positive_regulation of Casp3 9 0.39 2.93 8.2
30 INT98178 Localization of Casp3 32 0.65 21.01 7.77
31 INT92138 Binding of CDKN2A 28 0.37 25.64 7.47
32 INT16631 Negative_regulation of APC 46 0.57 30.53 7.11
33 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94
34 INT102749 Positive_regulation of Positive_regulation of CASP3 32 0.67 26.07 6.93
35 INT108585 Positive_regulation of Gene_expression of CASP3 35 0.70 28.37 6.45
36 INT57232 Binding of Casp3 22 0.36 9.42 6.2
37 INT3819 Positive_regulation of Apc 36 0.69 27.03 6.02
38 INT134544 Negative_regulation of Positive_regulation of CASP3 23 0.57 18.48 5.95
39 INT104330 Negative_regulation of CDKN1A 57 0.58 39.93 5.88
40 INT62270 Positive_regulation of Gene_expression of Cdkn1a 30 0.47 18.73 5.69
41 INT125467 Positive_regulation of Gene_expression of CDKN2A 35 0.63 39.07 5.56
42 INT13295 Positive_regulation of Cdkn2a 18 0.68 13.02 5.47
43 INT89794 Positive_regulation of CDKN2A 58 0.67 50.18 5.38
44 INT87022 Gene_expression of Apc 68 0.67 46.98 5.22
45 INT99549 Gene_expression of CDKN1B 30 0.75 17 5.15
46 INT57064 Positive_regulation of APC 72 0.66 48.5 5.08
47 INT160055 Localization of CDKN1A 15 0.78 12.56 4.83
48 INT337882 Gene_expression of Nr2f2 1 0.76 3.45 4.6
49 INT3817 Negative_regulation of Apc 29 0.58 22.12 3.91
50 INT63121 Binding of APC 29 0.41 23.02 3.8
51 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7
52 INT97126 Regulation of CASP3 9 0.40 8.15 3.6
53 INT82796 Regulation of CDKN1A 22 0.53 9.83 3.33
54 INT78471 Regulation of Gene_expression of CDKN2A 13 0.45 12.52 3.28
55 INT62268 Positive_regulation of Cdkn1a 33 0.67 14.12 3.26
56 INT137656 Negative_regulation of Binding of Casp3 4 0.21 0.7 3.09
57 INT75505 Regulation of Gene_expression of CDKN1A 24 0.60 12.24 3.07
58 INT75499 Positive_regulation of Positive_regulation of CDKN1A 12 0.60 7.28 2.84
59 INT78248 Negative_regulation of Cdkn2a 17 0.59 15.15 2.8
60 INT88852 Protein_catabolism of Casp3 28 0.65 23.57 2.74
61 INT99548 Positive_regulation of Gene_expression of CDKN1B 12 0.67 6.79 2.5
62 INT92141 Negative_regulation of CDKN2A 53 0.57 44.23 2.48
63 INT131112 Phosphorylation of Casp3 7 0.63 4.1 2.46
64 INT338170 Regulation of Regulation of CDKN2A 1 0.44 0.96 2.46
65 INT31118 Localization of Casp3 17 0.73 11.55 2.3
66 INT111038 Gene_expression of Cdkn1b 23 0.75 25.35 2.22
67 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14
68 INT98176 Positive_regulation of Localization of Casp3 7 0.33 6.85 2.12
69 INT337864 Positive_regulation of Gene_expression of Nr2f2 1 0.68 0.48 2.07
70 INT94772 Gene_expression of Cdkn2a 14 0.75 8.25 2.04
71 INT99547 Positive_regulation of CDKN1B 18 0.67 8.42 1.96
72 INT98782 Gene_expression of Cdkn1b 70 0.75 36.43 1.9
73 INT3818 Regulation of Apc 13 0.39 12.52 1.68
74 INT102532 Protein_catabolism of Casp3 24 0.64 16.78 1.64
75 INT104331 Negative_regulation of Gene_expression of CDKN1A 24 0.57 13.68 1.63
76 INT137505 Positive_regulation of Cdkn1b 18 0.67 10.55 1.54
77 INT106749 Negative_regulation of Negative_regulation of Casp3 6 0.34 5.12 1.48
78 INT54996 Regulation of KAT2B 1 0.19 0.38 1.45
79 INT140843 Regulation of Phosphorylation of Casp3 1 0.25 0.37 1.44
80 INT78470 Negative_regulation of Gene_expression of CDKN2A 14 0.59 14.44 1.38
81 INT220177 Binding of Apc 21 0.37 15.34 1.37
82 INT171690 Transcription of Casp3 8 0.55 2.62 1.36
83 INT97943 Positive_regulation of Protein_catabolism of Casp3 7 0.28 7.4 1.35
84 INT110434 Positive_regulation of Gene_expression of Apc 20 0.50 11.37 1.3
85 INT136574 Regulation of TNFAIP3 2 0.11 1.33 1.3
86 INT160009 Transcription of CDKN1B 2 0.67 1.43 1.29
87 INT114220 Negative_regulation of Gene_expression of Cdkn1b 4 0.33 4.11 1.23
88 INT102073 Regulation of Gene_expression of APC 5 0.45 6.09 1.15
89 INT102074 Positive_regulation of Gene_expression of APC 20 0.50 13.66 1.1
90 INT160008 Positive_regulation of Transcription of CDKN1B 1 0.49 0.98 1.1
91 INT111036 Positive_regulation of Cdkn1b 16 0.45 9 1.06
92 INT102845 Localization of CASP3 7 0.81 2.81 1.06
93 INT111037 Positive_regulation of Gene_expression of Cdkn1b 5 0.39 11.17 1.06
94 INT42104 Regulation of Cdkn2a 4 0.44 5.67 1.06
95 INT160012 Regulation of Gene_expression of CDKN1B 2 0.44 1.17 1.04
96 INT337876 Regulation of Nr2f2 1 0.61 0.18 0.96
97 INT338168 Positive_regulation of Binding of CDKN2A 1 0.49 0.52 0.94
98 INT31117 Binding of Casp3 14 0.23 5.27 0.93
99 INT156976 Gene_expression of TNFAIP3 4 0.65 5.25 0.93
100 INT337865 Regulation of Gene_expression of Nr2f2 1 0.61 0.31 0.92
101 INT242134 Localization of Apc 8 0.74 4.83 0.88
102 INT337872 Negative_regulation of Gene_expression of Nr2f2 1 0.42 0.55 0.86
103 INT347182 Negative_regulation of TNFAIP3 3 0.23 5.6 0.84
104 INT131105 Positive_regulation of Negative_regulation of Casp3 3 0.29 3.15 0.84
105 INT220498 Negative_regulation of Gene_expression of Cdkn1b 9 0.21 7.48 0.8
106 INT146521 Negative_regulation of Positive_regulation of CDKN1A 6 0.42 3.29 0.79
107 INT144429 Positive_regulation of Cdkn2a 7 0.58 4.05 0.78
108 INT181667 Regulation of Regulation of Casp3 1 0.22 1.7 0.77
109 INT129115 Negative_regulation of Cdkn2a 16 0.50 17.03 0.76
110 INT337873 Positive_regulation of Nr2f2 1 0.68 0.48 0.73
111 INT129490 Negative_regulation of Protein_catabolism of Casp3 4 0.22 3.91 0.71
112 INT57062 Regulation of APC 24 0.58 14.3 0.7
113 INT80674 Negative_regulation of Gene_expression of APC 16 0.59 18.14 0.69
114 INT351454 Regulation of Transcription of Casp3 1 0.02 0.51 0.67
115 INT264003 Positive_regulation of Transcription of TNFAIP3 1 0.38 1.01 0.65
116 INT131976 Positive_regulation of Protein_catabolism of CASP3 4 0.49 3.76 0.64
117 INT263996 Transcription of TNFAIP3 1 0.39 0.99 0.64
118 INT126732 Regulation of Cdkn1a 6 0.39 2.13 0.63
119 INT197832 Localization of MEN1 1 0.80 11.01 0.63
120 INT251026 Negative_regulation of Phosphorylation of CDKN2A 5 0.42 5.02 0.62
121 INT177886 Positive_regulation of Gene_expression of Cdkn2a 3 0.67 3.42 0.62
122 INT241621 Regulation of Cdkn1b 2 0.06 0.36 0.62
123 INT113850 Negative_regulation of Cdkn1b 4 0.42 3.45 0.6
124 INT147598 Negative_regulation of Positive_regulation of CDKN2A 3 0.41 1.47 0.59
125 INT242061 Positive_regulation of Negative_regulation of Casp3 3 0.09 1.7 0.58
126 INT98786 Positive_regulation of Gene_expression of Cdkn1b 21 0.67 8.7 0.56
127 INT181673 Negative_regulation of Transcription of Casp3 3 0.34 0.61 0.55
128 INT120358 Positive_regulation of Positive_regulation of CDKN1B 2 0.49 1.26 0.55
129 INT242011 Localization of Cdkn2a 4 0.73 2.49 0.54
130 INT72869 Regulation of Negative_regulation of APC 2 0.36 1.7 0.54
131 INT144701 Gene_expression of Cdkn2a 15 0.75 8.42 0.53
132 INT144431 Positive_regulation of Transcription of Cdkn2a 1 0.41 1.11 0.51
133 INT144426 Transcription of Cdkn2a 1 0.42 1.11 0.51
134 INT163828 Localization of Cdkn1b 4 0.66 5.2 0.48
135 INT61813 Localization of TFAP4 1 0.73 0 0.47
136 INT151720 Negative_regulation of Positive_regulation of Apc 3 0.37 2.15 0.46
137 INT137504 Positive_regulation of Positive_regulation of Cdkn1b 2 0.45 1.71 0.45
138 INT163829 Positive_regulation of Localization of Cdkn1b 2 0.17 0.96 0.45
139 INT61812 Gene_expression of TFAP4 1 0.65 0 0.45
140 INT220088 Positive_regulation of Positive_regulation of CDKN2A 4 0.49 4.04 0.44
141 INT129144 Regulation of Localization of Casp3 1 0.26 0.84 0.44
142 INT61102 Gene_expression of MEN1 12 0.78 17.7 0.43
143 INT153436 Positive_regulation of Localization of Casp3 3 0.49 2.12 0.43
144 INT97606 Negative_regulation of Cdkn1a 7 0.43 4.24 0.42
145 INT132496 Regulation of Gene_expression of CASP3 6 0.20 4.59 0.42
146 INT152151 Regulation of Gene_expression of Apc 4 0.44 3.87 0.42
147 INT252657 Positive_regulation of Phosphorylation of CDKN2A 2 0.45 3.09 0.42
148 INT42105 Regulation of Positive_regulation of Cdkn2a 1 0.44 0.33 0.42
149 INT125592 Negative_regulation of Negative_regulation of CDKN1A 2 0.42 2.07 0.41
150 INT117440 Positive_regulation of Cdkn1a 3 0.67 2.95 0.4
151 INT155293 Positive_regulation of Protein_catabolism of Casp3 3 0.45 1.7 0.4
152 INT131018 Phosphorylation of Cdkn1a 3 0.61 2.06 0.4
153 INT239084 Localization of KAT2B 4 0.73 3.08 0.36
154 INT220170 Regulation of Positive_regulation of Apc 1 0.10 0.46 0.35
155 INT165916 Negative_regulation of Localization of Casp3 2 0.41 2.41 0.34
156 INT204065 Regulation of Gene_expression of Cdkn1b 1 0.06 3.49 0.34
157 INT118243 Transcription of APC 4 0.45 3.33 0.33
158 INT184605 Positive_regulation of Transcription of APC 2 0.19 2.39 0.33
159 INT129153 Phosphorylation of CDKN1B 2 0.61 1.41 0.33
160 INT82797 Transcription of CDKN1A 11 0.69 8.01 0.32
161 INT196323 Localization of Cdkn2a 8 0.73 9.1 0.32
162 INT131017 Positive_regulation of Positive_regulation of Cdkn1a 5 0.67 1.89 0.32
163 INT251025 Phosphorylation of CDKN2A 4 0.61 3.19 0.32
164 INT225667 Transcription of Apc 3 0.52 3.73 0.32
165 INT119269 Binding of CDKN1A 14 0.47 8.82 0.31
166 INT195672 Localization of APC 7 0.74 3.76 0.3
167 INT123529 Phosphorylation of CDKN1A 8 0.80 5.69 0.29
168 INT228477 Positive_regulation of Gene_expression of Cdkn2a 2 0.11 1.3 0.29
169 INT247096 Binding of NR2F2 1 0.01 0.74 0.29
170 INT266973 Negative_regulation of KAT2B 1 0.01 0.99 0.29
171 INT159320 Negative_regulation of Protein_catabolism of CASP3 1 0.21 0.59 0.27
172 INT184624 Localization of CDKN2A 8 0.74 7.87 0.25
173 INT238494 Regulation of Transcription of CDKN2A 1 0.16 5.62 0.25
174 INT225177 Regulation of Negative_regulation of CDKN1A 1 0.39 0.26 0.25
175 INT141820 Positive_regulation of Binding of Casp3 1 0.12 0.55 0.24
176 INT179043 Negative_regulation of Cdkn1b 7 0.36 5.99 0.22
177 INT233869 Binding of CDKN1B 2 0.47 0.46 0.22
178 INT225666 Regulation of Transcription of Apc 1 0.29 0.33 0.22
179 INT179889 Negative_regulation of CDKN1B 4 0.57 1.71 0.21
180 INT306296 Regulation of CDKN1B 1 0.19 0.46 0.21
181 INT195018 Regulation of Negative_regulation of Casp3 1 0.21 0.48 0.2
182 INT173166 Negative_regulation of Binding of APC 3 0.40 3.01 0.19
183 INT241687 Binding of Cdkn2a 5 0.31 5.26 0.18
184 INT179044 Regulation of Cdkn1b 4 0.22 2.64 0.18
185 INT309916 Negative_regulation of NR2F2 1 0.02 0.7 0.18
186 INT57065 Negative_regulation of Positive_regulation of APC 3 0.22 2.43 0.17
187 INT228603 Positive_regulation of Positive_regulation of Apc 1 0.24 0.24 0.17
188 INT178607 Binding of CASP3 5 0.19 1.06 0.16
189 INT201689 Protein_catabolism of CDKN1B 3 0.96 0.7 0.16
190 INT147149 Transcription of CDKN2A 8 0.67 6.85 0.15
191 INT225216 Negative_regulation of Negative_regulation of Cdkn2a 1 0.42 3.16 0.15
192 INT245263 Negative_regulation of Gene_expression of Cdkn1a 5 0.25 1.84 0.14
193 INT123522 Phosphorylation of Casp3 3 0.80 1.36 0.14
194 INT257863 Positive_regulation of Protein_catabolism of Cdkn1b 1 0.45 0.43 0.14
195 INT257865 Negative_regulation of Protein_catabolism of Cdkn1b 1 0.42 0.43 0.14
196 INT257858 Protein_catabolism of Cdkn1b 1 0.64 0.43 0.14
197 INT123181 Positive_regulation of Negative_regulation of CDKN1A 1 0.49 0.6 0.14
198 INT61789 Negative_regulation of Cdkn1a 2 0.41 1.35 0.13
199 INT250790 Negative_regulation of Localization of APC 2 0.13 2.3 0.13
200 INT250792 Positive_regulation of Localization of APC 1 0.15 0.48 0.13
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