GO:0045741

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Name positive regulation of epidermal growth factor-activated receptor activity
Categary Process
Go Slim No
Go Link GO:0045741
Unique Molecular Interactions 408
Total Molecular Interactions 568
Total Single Events 3153
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of epidermal growth factor-activated receptor activity. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of epidermal growth factor-activated receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
2 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
3 INT356289 Binding of Egfr and Egf 1 0.13 3.02 2.52
4 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
5 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
6 INT220751 EGF Regulation of GOPC 1 0.08 0 1.18
7 INT220752 Negative_regulation of EGF Regulation of NAV1 1 0.26 0 1.18
8 INT220753 Negative_regulation of EGF Regulation of GOPC 1 0.08 0 1.18
9 INT220748 EGF Regulation of NAV1 1 0.28 0 1.17
10 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
11 INT136989 EGF Negative_regulation of Positive_regulation of KCNJ2 1 0.04 1.09 1.1
12 INT136988 EGF Negative_regulation of KCNJ2 1 0.04 1.09 1.04
13 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
14 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
15 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
16 INT258170 Binding of Adora1 and Ppap2a 1 0.05 0.26 0.94
17 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93
18 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
19 INT169469 Binding of Egfr and Tgfa 1 0.19 1.87 0.91
20 INT118288 EGF Positive_regulation of Phosphorylation of EGFR 9 0.54 3.85 0.9
21 INT220744 EGF Positive_regulation of Gene_expression of KRT20 1 0.01 1.26 0.9
22 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
23 INT134454 EGF Positive_regulation of EGFR 3 0.56 1.32 0.88
24 INT134453 Negative_regulation of EGF Positive_regulation of EGFR 1 0.35 0.35 0.88
25 INT43796 Binding of CDS1 and Adra2a 1 0.06 0 0.86
26 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
27 INT220739 EGF Positive_regulation of Transcription of NAV1 1 0.31 0.16 0.83
28 INT117341 ADAM17 Positive_regulation of EGFR 1 0.16 3.56 0.82
29 INT84039 EGF Positive_regulation of Gene_expression of CPOX 2 0.11 1.88 0.8
30 INT84040 EGF Positive_regulation of CPOX 2 0.07 1.91 0.8
31 INT220747 Binding of PCa and EGF 1 0.05 1.42 0.8
32 INT42797 Egf Regulation of Gene_expression of Penk 1 0.21 0.07 0.8
33 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
34 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
35 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79
36 INT102162 Binding of TNF and Adam17 1 0.14 0.88 0.78
37 INT110130 NR3C1 Regulation of ADORA1 1 0.04 0.73 0.77
38 INT102159 Binding of Adam17 and Mmp2 1 0.18 0.87 0.77
39 INT231031 Egf Positive_regulation of Sec22b 1 0.03 0.05 0.76
40 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
41 INT84283 Binding of Adra2a and Htr1f 1 0.16 0.15 0.74
42 INT220746 EGF Positive_regulation of Gene_expression of GOPC 1 0.13 0 0.72
43 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
44 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
45 INT104301 Adam17 Regulation of Negative_regulation of Sell 1 0.39 0.58 0.69
46 INT220738 EGF Regulation of Gene_expression of EGFR 1 0.09 0.6 0.67
47 INT132152 Adra2a Regulation of Localization of Abat 1 0.03 0 0.66
48 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
49 INT215647 Adora1 Positive_regulation of Kcnj5 1 0.00 0 0.62
50 INT17187 Binding of Adra2a and Fabp6 1 0.16 0.69 0.61
51 INT17186 Positive_regulation of Binding of Adra2a and Fabp6 1 0.21 0.69 0.61
52 INT169287 EGF Positive_regulation of Localization of IL8 1 0.15 0.13 0.61
53 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
54 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
55 INT199976 EGF Regulation of ITGB3BP 1 0.02 0.77 0.57
56 INT41250 Binding of Adra2a and Eef1a1 1 0.06 0.4 0.56
57 INT121994 EGF Positive_regulation of Positive_regulation of MAPK1 1 0.25 0 0.55
58 INT121993 Binding of EGF and SGCG 1 0.40 0 0.55
59 INT311256 Nt5e Positive_regulation of Positive_regulation of Adora1 1 0.49 0.19 0.54
60 INT220745 EGF Positive_regulation of Positive_regulation of PCa 1 0.05 0.79 0.52
61 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
62 INT98734 Egf Negative_regulation of Tk1 1 0.13 0.15 0.49
63 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49
64 INT7851 Man2a2 Positive_regulation of Adra2a 1 0.13 0 0.49
65 INT295708 Binding of EGF and CCL2 1 0.01 0.79 0.49
66 INT108329 EGF Positive_regulation of Phosphorylation of EPHB2 4 0.48 3.96 0.48
67 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
68 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
69 INT26448 Adra2a Regulation of Positive_regulation of Npy 1 0.06 0 0.46
70 INT108332 EGF Positive_regulation of Phosphorylation of MAPK1 5 0.48 1.85 0.45
71 INT169478 TGFB3 Positive_regulation of Tgfa 1 0.01 0.9 0.44
72 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
73 INT165724 Bdkrb1 Positive_regulation of Adora1 1 0.24 1.65 0.43
74 INT295406 Egf Regulation of Gene_expression of Oprk1 1 0.01 0.72 0.43
75 INT311590 EGF Regulation of Gene_expression of CXCL10 1 0.23 0.51 0.43
76 INT56576 Adra2a Positive_regulation of Localization of Gnrh1 1 0.44 0 0.43
77 INT311589 EGF Regulation of Gene_expression of VEGFA 1 0.18 0.51 0.43
78 INT55395 Binding of Htr1a and Adra2a 1 0.42 0 0.43
79 INT311591 CXCL10 Regulation of Gene_expression of EGF 1 0.23 0.51 0.43
80 INT13281 Egf Regulation of Ngf 1 0.66 0.12 0.42
81 INT13279 Ngf Regulation of Egf 1 0.49 0.12 0.42
82 INT215651 Binding of Adora1 and Cpa1 1 0.00 0 0.42
83 INT13283 Egf Regulation of Fgf2 1 0.49 0.11 0.41
84 INT13284 Fgf2 Regulation of Egf 1 0.49 0.11 0.41
85 INT34987 Adra2a Positive_regulation of Localization of Gnrhr 1 0.43 0 0.4
86 INT90807 EGF Positive_regulation of Oprd1 1 0.00 0.39 0.39
87 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
88 INT283840 Binding of Egf and hb 1 0.21 1.34 0.38
89 INT70656 Adra2a Regulation of Gene_expression of Npy 1 0.23 0 0.38
90 INT356274 Egf Positive_regulation of Localization of Stat3 1 0.13 0.22 0.36
91 INT295407 Egf Positive_regulation of Localization of Oprk1 1 0.02 0.67 0.36
92 INT94875 Binding of Calca and Egf 1 0.25 0 0.35
93 INT188193 Negative_regulation of EGF Positive_regulation of MAPK1 1 0.28 0.54 0.34
94 INT156831 EGF Positive_regulation of MAPK1 2 0.45 0.27 0.33
95 INT67030 Negative_regulation of Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
96 INT67028 Adra2a Negative_regulation of Nts 1 0.06 0.64 0.33
97 INT67029 Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
98 INT31182 Adra2a Regulation of Localization of Gh 1 0.01 0.35 0.32
99 INT220740 EGF Positive_regulation of Regulation of NAV1 1 0.31 0.61 0.32
100 INT220749 EGF Positive_regulation of Positive_regulation of KRT20 1 0.01 0.61 0.32
101 INT299549 Binding of TGFB1 and Egf 1 0.02 0.32 0.32
102 INT75769 Egf Positive_regulation of Cpox 1 0.26 0.76 0.31
103 INT170496 Egf Positive_regulation of Mapk1 3 0.21 0.5 0.3
104 INT356288 Egf Positive_regulation of Trib3 1 0.00 0.17 0.3
105 INT215645 Binding of Adora1 and Kcnj5 1 0.00 0.08 0.29
106 INT303440 Egf Positive_regulation of Gene_expression of Col7a1 1 0.07 0.92 0.28
107 INT67199 Tgfa Regulation of Localization of IL8 1 0.00 0.66 0.28
108 INT215653 Binding of Adora1 and Adora3 1 0.39 0.07 0.27
109 INT67198 IL8 Regulation of Tgfa 1 0.00 0.65 0.27
110 INT193027 EGF Positive_regulation of Positive_regulation of MRGPRX1 1 0.02 0 0.27
111 INT285243 EGF Positive_regulation of Egf 1 0.00 1.55 0.27
112 INT285238 EGF Positive_regulation of VEGFA 1 0.01 1.55 0.27
113 INT144255 EGF Regulation of Positive_regulation of NFKB1 1 0.41 0.66 0.27
114 INT95061 Binding of Adra2a and ADHD1 1 0.02 0.8 0.27
115 INT195898 Negative_regulation of Egf Negative_regulation of Gene_expression of Cpox 1 0.03 0.3 0.26
116 INT171384 Egf Negative_regulation of Positive_regulation of Mapk1 1 0.16 0.24 0.26
117 INT42635 Adra2a Positive_regulation of epi 1 0.00 0 0.26
118 INT235013 Binding of DSG1 and Adam17 1 0.07 1.34 0.26
119 INT234980 Positive_regulation of Egfr Positive_regulation of Adam17 1 0.09 1.33 0.26
120 INT332242 Binding of Egf and Pdgfa 1 0.07 0.97 0.25
121 INT215652 Binding of Adora1 and Npy1r 1 0.39 0.22 0.24
122 INT55641 Binding of CHRM1 and Adra2a 1 0.00 0 0.24
123 INT183247 ADA Negative_regulation of ADORA1 1 0.01 0 0.23
124 INT9720 Binding of TGFB1 and Egf 1 0.01 0 0.23
125 INT220750 EGF Positive_regulation of PCa 1 0.05 0.45 0.23
126 INT173294 LPA Positive_regulation of EGF 1 0.01 0.07 0.23
127 INT173292 F2 Positive_regulation of EGF 1 0.00 0.07 0.23
128 INT32735 ADRA2A Regulation of RTCA 1 0.07 0 0.22
129 INT9717 Binding of Egf and Fgfr1 1 0.15 0 0.22
130 INT9716 Binding of Egf and Pdgfc 1 0.20 0 0.22
131 INT193033 Binding of CHRM1 and EGF 1 0.01 1.96 0.22
132 INT9718 Binding of Egf and Ngf 1 0.30 0 0.21
133 INT193035 Positive_regulation of PDGFA Positive_regulation of EGF 1 0.05 0.53 0.21
134 INT188203 EGF Positive_regulation of Protein_catabolism of OSM 1 0.30 0.17 0.21
135 INT9715 Binding of Egf and Tgfa 1 0.18 0 0.21
136 INT112136 Egf Positive_regulation of Gene_expression of Ptgs2 1 0.21 0.19 0.21
137 INT193025 PDGFA Positive_regulation of EGF 1 0.05 0.53 0.21
138 INT193036 EGF Positive_regulation of PDGFA 1 0.05 0.53 0.21
139 INT193032 Positive_regulation of EGF Positive_regulation of PDGFA 1 0.05 0.53 0.21
140 INT145152 Binding of EGF and EGFR 4 0.15 2.45 0.19
141 INT14869 Binding of EGF and TGFB3 1 0.14 0.69 0.19
142 INT23655 Binding of POMC and Egf 1 0.04 0 0.19
143 INT332247 Egf Positive_regulation of Stat6 1 0.13 1.23 0.19
144 INT186098 EGF Positive_regulation of MAP2K5 1 0.01 0.19 0.18
145 INT274168 Egf Positive_regulation of Gene_expression of Muc5ac 1 0.01 2.11 0.17
146 INT261477 Egf Positive_regulation of Positive_regulation of Ephb1 1 0.37 0.21 0.17
147 INT24668 Binding of COL7A1 and EGF 1 0.14 0.25 0.16
148 INT117137 Gene_expression of ROS1 Positive_regulation of Protein_catabolism of Egf 1 0.00 0 0.16
149 INT293712 Binding of Adra2a and Atl1 1 0.06 0.83 0.15
150 INT238329 EGF Regulation of Negative_regulation of ADAMTS5 1 0.03 0 0.14
151 INT249322 Positive_regulation of Adora1 Regulation of Rit2 1 0.10 0 0.14
152 INT238338 Binding of EGF and Regulation of Gene_expression of GOPC 1 0.05 0 0.14
153 INT103425 Binding of Adra2a and Cyth2 1 0.00 0 0.14
154 INT109082 Adra2a Regulation of Nppa 1 0.21 0.56 0.14
155 INT238337 EGF Regulation of Gene_expression of GOPC 1 0.03 0 0.14
156 INT238342 Binding of EGF and Regulation of Gene_expression of ADAMTS1 1 0.05 0 0.14
157 INT356285 Binding of Stat3 and Egf 1 0.09 0.4 0.13
158 INT73924 EGF Positive_regulation of Localization of COL7A1 1 0.31 0.33 0.13
159 INT253015 Egf Regulation of PTTG1 1 0.02 0.44 0.13
160 INT108330 EGF Negative_regulation of EPHB2 1 0.41 1.15 0.13
161 INT299547 Negative_regulation of Binding of TGFB1 and Egf 1 0.02 0.1 0.13
162 INT249321 Positive_regulation of Adora1 Regulation of Preb 1 0.20 0.09 0.12
163 INT195896 Egf Positive_regulation of Nos1 1 0.10 0.57 0.12
164 INT356276 Egf Positive_regulation of Positive_regulation of Mapk1 1 0.05 0.52 0.12
165 INT259629 Binding of Adam17 and Timp3 1 0.01 0.19 0.11
166 INT299551 Regulation of Binding of TGFB1 and Egf 1 0.03 0.21 0.11
167 INT146937 Egf Regulation of Trpm6 1 0.03 0.27 0.11
168 INT287267 EGF Positive_regulation of CDC42 1 0.12 0.16 0.11
169 INT156829 EGF Positive_regulation of MAPK3 2 0.08 0.87 0.1
170 INT17394 Adra2a Positive_regulation of GNAI1 1 0.02 0.37 0.1
171 INT346526 Binding of ADORA1 and PTH1R 1 0.01 0 0.1
172 INT356272 Egf Negative_regulation of Gene_expression of Egfr 1 0.15 0.2 0.1
173 INT222553 Binding of Sdc1 and Egf 1 0.02 0 0.1
174 INT286963 EGF Positive_regulation of Gene_expression of STAT3 1 0.03 0.57 0.1
175 INT250661 Binding of EGF and ERBB2 2 0.11 0.82 0.08
176 INT27109 Egf Regulation of Gast 1 0.42 0 0.08
177 INT66171 Negative_regulation of Adra2a Negative_regulation of Positive_regulation of Pnmt 1 0.38 0 0.08
178 INT110856 TXK Negative_regulation of Egf 1 0.02 1.2 0.08
179 INT353070 ADAM17 Positive_regulation of TNF 1 0.19 1.66 0.08
180 INT309903 Binding of EGF and TXK 1 0.03 0.23 0.08
181 INT110855 Pkia Negative_regulation of Egf 1 0.15 1.2 0.08
182 INT222139 Binding of Egf and Fgf2 1 0.12 0 0.07
183 INT188210 EGF Positive_regulation of OSM 1 0.28 0 0.07
184 INT188208 EGF Regulation of STAT3 1 0.46 0 0.07
185 INT66166 Negative_regulation of Binding of Pnmt and Adra2a 1 0.38 0 0.07
186 INT299535 Binding of Egf and Lif 1 0.07 0 0.07
187 INT246539 EGF Negative_regulation of Gene_expression of PDGFA 1 0.06 0.38 0.07
188 INT246538 PDGFA Negative_regulation of Gene_expression of EGF 1 0.06 0.38 0.07
189 INT66167 Negative_regulation of Pnmt Negative_regulation of Adra2a 1 0.38 0 0.07
190 INT66172 Binding of Pnmt and Adra2a 1 0.33 0 0.07
191 INT339101 ERBB2 Positive_regulation of TGFA 1 0.33 0.68 0.06
192 INT24666 Binding of EGF and FGF2 1 0.35 0 0.06
193 INT225262 Egf Regulation of Gene_expression of S100a7a 1 0.04 3.31 0.06
194 INT338019 Egf Positive_regulation of AR 1 0.07 1.02 0.05
195 INT27738 CBS Positive_regulation of EGF 1 0.33 0.85 0.05
196 INT225261 S100a7a Positive_regulation of Egf 1 0.07 1.13 0.05
197 INT27737 CBS Positive_regulation of Positive_regulation of EGF 1 0.36 0.85 0.05
198 INT295337 Egf Positive_regulation of Ptpn11 1 0.15 0.08 0.05
199 INT186097 EGF Positive_regulation of Positive_regulation of EGFR 1 0.20 0.38 0.04
200 INT295358 Egf Positive_regulation of Ddr1 1 0.03 0.1 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of epidermal growth factor-activated receptor activity. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of epidermal growth factor-activated receptor activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
2 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
3 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
4 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47
5 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
6 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
7 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
8 INT11157 Binding of EGF 88 0.48 53.73 21.25
9 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
10 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
11 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
12 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
13 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
14 INT27739 Positive_regulation of EGF 49 0.70 28.31 13.68
15 INT13823 Gene_expression of Egf 97 0.78 39.99 12.99
16 INT19155 Binding of Adora1 25 0.47 6.41 10.72
17 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
18 INT2036 Localization of EGF 42 0.77 21.5 9.74
19 INT24328 Gene_expression of Egf 97 0.75 59.65 9.42
20 INT114406 Gene_expression of Adora1 28 0.72 6.83 9.13
21 INT22771 Positive_regulation of Egf 44 0.70 16.45 8.64
22 INT9350 Regulation of ADORA1 9 0.12 1.53 7.79
23 INT101699 Regulation of Adora1 14 0.61 3.7 7.59
24 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
25 INT40159 Negative_regulation of Adora1 13 0.51 3.51 7.13
26 INT76197 Positive_regulation of ADORA1 7 0.59 5.06 7
27 INT9167 Binding of Adora1 6 0.40 0.53 6.9
28 INT76255 Gene_expression of ADORA1 11 0.78 2.51 6.85
29 INT2037 Negative_regulation of EGF 30 0.59 15.05 6.81
30 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
31 INT130875 Gene_expression of ADAM17 13 0.78 15.46 6.41
32 INT13822 Localization of Egf 30 0.81 13.79 6.4
33 INT37227 Regulation of EGF 19 0.45 11.16 5.17
34 INT21901 Negative_regulation of Egf 25 0.58 10.46 4.99
35 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
36 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
37 INT104299 Negative_regulation of Adam17 18 0.47 12.03 4.39
38 INT65926 Positive_regulation of Gene_expression of Egf 26 0.70 12.91 4.18
39 INT23653 Binding of Egf 22 0.36 11.34 4.12
40 INT65527 Positive_regulation of Positive_regulation of Adora1 4 0.46 0.67 3.71
41 INT31758 Positive_regulation of Egf 32 0.66 19.42 3.64
42 INT18920 Binding of Egf 24 0.48 9.43 3.57
43 INT215604 Localization of Adora1 10 0.78 1.47 3.49
44 INT8096 Positive_regulation of Gene_expression of EGF 21 0.69 13.43 3.47
45 INT101477 Binding of ADORA1 8 0.31 0.42 3.07
46 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
47 INT31757 Negative_regulation of Egf 18 0.41 9.7 2.94
48 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
49 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
50 INT117785 Regulation of Gene_expression of EGF 7 0.44 4.22 2.87
51 INT102157 Gene_expression of Adam17 3 0.58 4.17 2.86
52 INT54178 Regulation of Adora1 5 0.39 0.29 2.85
53 INT215608 Negative_regulation of Binding of Adora1 5 0.41 1.35 2.73
54 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
55 INT215601 Regulation of Positive_regulation of Adora1 9 0.60 1.74 2.66
56 INT215599 Positive_regulation of Positive_regulation of Adora1 7 0.47 2.29 2.58
57 INT28878 Negative_regulation of Localization of Egf 6 0.49 10.34 2.57
58 INT77636 Phosphorylation of Egf 11 0.61 1.69 2.56
59 INT114020 Gene_expression of Adora1 2 0.33 4.24 2.55
60 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
61 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
62 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
63 INT215611 Negative_regulation of Positive_regulation of Adora1 6 0.43 1.18 2.16
64 INT82226 Negative_regulation of Gene_expression of EGF 11 0.58 6.36 2.13
65 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
66 INT108335 Phosphorylation of EGF 17 0.80 7.3 2.09
67 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
68 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
69 INT32558 Negative_regulation of ADORA1 5 0.12 2.77 1.86
70 INT117346 Positive_regulation of ADAM17 5 0.50 6.69 1.86
71 INT172961 Localization of Egf 26 0.71 16.74 1.81
72 INT124556 Negative_regulation of Positive_regulation of Adora1 3 0.51 1.2 1.81
73 INT73721 Negative_regulation of Gene_expression of Egf 5 0.43 2.28 1.8
74 INT90800 Negative_regulation of Positive_regulation of EGF 5 0.40 2.78 1.77
75 INT130874 Negative_regulation of Gene_expression of ADAM17 3 0.43 5.03 1.76
76 INT168519 Positive_regulation of Gene_expression of Adora1 4 0.61 0.75 1.75
77 INT19747 Regulation of Egf 14 0.46 4.67 1.68
78 INT29763 Negative_regulation of Adora1 3 0.42 0 1.64
79 INT130332 Gene_expression of Adam17 14 0.50 4.84 1.56
80 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
81 INT114525 Negative_regulation of Positive_regulation of Egf 4 0.35 2.93 1.5
82 INT7780 Positive_regulation of Negative_regulation of Adra2a 2 0.50 0.09 1.48
83 INT86382 Negative_regulation of Localization of EGF 5 0.43 1.75 1.44
84 INT7932 Protein_catabolism of Adra2a 1 1.00 0 1.44
85 INT241721 Positive_regulation of Transcription of Adora1 3 0.50 1.39 1.41
86 INT53632 Regulation of Negative_regulation of Adra2a 1 0.23 0.08 1.41
87 INT29262 Negative_regulation of Binding of Adra2a 4 0.40 0.25 1.37
88 INT27656 Gene_expression of Tgfa 6 0.74 3.37 1.32
89 INT36337 Localization of Tgfa 4 0.73 0.83 1.32
90 INT95815 Regulation of Positive_regulation of Adra2a 4 0.45 1.45 1.32
91 INT241737 Transcription of Adora1 3 0.72 0.89 1.32
92 INT78861 Negative_regulation of Transcription of Adam17 2 0.29 1.4 1.32
93 INT78859 Transcription of Adam17 2 0.47 1.39 1.31
94 INT7847 Positive_regulation of Localization of Adra2a 2 0.40 0.22 1.28
95 INT234893 Positive_regulation of Adam17 4 0.38 3.78 1.22
96 INT79489 Transcription of Adra2a 2 0.61 2.38 1.22
97 INT27108 Positive_regulation of Localization of Egf 5 0.50 2.91 1.21
98 INT102615 Positive_regulation of Gene_expression of Tgfa 5 0.44 3.93 1.17
99 INT58311 Regulation of Localization of EGF 3 0.54 1.06 1.16
100 INT162124 Positive_regulation of Phosphorylation of Egf 3 0.45 0.77 1.14
101 INT76254 Positive_regulation of Positive_regulation of ADORA1 2 0.43 1.27 1.14
102 INT22770 Regulation of Gene_expression of Egf 5 0.44 2.56 1.12
103 INT37207 Positive_regulation of Positive_regulation of Egf 4 0.50 0.76 1.07
104 INT13817 Protein_catabolism of EGF 3 1.00 1.44 1.06
105 INT105860 Positive_regulation of Positive_regulation of EGF 6 0.64 2.37 1.05
106 INT132435 Negative_regulation of ADAM17 2 0.50 3.75 1.02
107 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
108 INT184240 Positive_regulation of Localization of Egf 2 0.27 3.58 0.99
109 INT20687 Positive_regulation of Regulation of Adra2a 1 0.35 1.07 0.95
110 INT18801 Negative_regulation of Negative_regulation of Adra2a 2 0.43 0 0.91
111 INT215606 Positive_regulation of Localization of Adora1 3 0.49 0.44 0.87
112 INT118290 Regulation of Phosphorylation of EGF 1 0.32 0.72 0.87
113 INT24327 Gene_expression of Tgfa 6 0.64 3.61 0.86
114 INT171372 Positive_regulation of Gene_expression of Egf 16 0.66 9.82 0.84
115 INT92880 Localization of ADORA1 2 0.80 0.09 0.84
116 INT77295 Positive_regulation of Tgfa 2 0.34 0.05 0.8
117 INT14770 Localization of Adra2a 2 0.60 0.1 0.78
118 INT31759 Negative_regulation of Gene_expression of Egf 6 0.53 5.33 0.77
119 INT89340 Positive_regulation of EREG 5 0.69 4.98 0.77
120 INT18836 Localization of ADRA2A 2 0.38 0.33 0.76
121 INT113512 Regulation of Gene_expression of ADORA1 1 0.11 0.19 0.73
122 INT11102 Negative_regulation of Regulation of Adra2a 2 0.42 1.5 0.71
123 INT22772 Positive_regulation of Negative_regulation of Egf 1 0.50 1.48 0.71
124 INT70652 Negative_regulation of Binding of EGF 7 0.43 4.23 0.7
125 INT110854 Phosphorylation of Egf 8 0.75 5.62 0.67
126 INT7609 Regulation of Positive_regulation of Adra2a 3 0.32 0.59 0.66
127 INT228279 Regulation of Gene_expression of Egf 7 0.43 6.64 0.65
128 INT54183 Regulation of Positive_regulation of Adora1 1 0.17 0 0.65
129 INT215607 Positive_regulation of Negative_regulation of Adora1 1 0.45 0 0.63
130 INT260422 Positive_regulation of Localization of EGF 3 0.10 1.58 0.56
131 INT138678 Transcription of ADAM17 1 0.69 4.9 0.56
132 INT82128 Negative_regulation of Transcription of Adra2a 1 0.18 1.32 0.55
133 INT59394 Regulation of Regulation of Adra2a 1 0.17 0 0.55
134 INT31363 Positive_regulation of Regulation of Adra2a 1 0.04 0 0.55
135 INT30428 Positive_regulation of Binding of ADRA2A 1 0.34 0.59 0.53
136 INT216748 Regulation of Localization of ADORA1 1 0.07 0.09 0.53
137 INT115532 Negative_regulation of Positive_regulation of Egf 3 0.28 1.38 0.52
138 INT59386 Binding of Tgfa 2 0.06 0.41 0.52
139 INT279525 Negative_regulation of Transcription of Adora1 1 0.43 0.26 0.51
140 INT138676 Localization of ADAM17 4 0.73 4.91 0.5
141 INT77904 Negative_regulation of Gene_expression of Adra2a 2 0.43 0.87 0.5
142 INT249309 Regulation of Gene_expression of Adora1 6 0.39 0.51 0.49
143 INT41146 Negative_regulation of Localization of Adra2a 1 0.37 0.1 0.49
144 INT215600 Regulation of Binding of Adora1 1 0.08 0.09 0.48
145 INT29102 Transcription of ADRA2A 2 0.27 0.83 0.46
146 INT33171 Positive_regulation of Negative_regulation of Adra2a 1 0.39 0 0.4
147 INT251556 Localization of Adam17 2 0.38 2 0.39
148 INT89341 Gene_expression of EREG 3 0.78 2.38 0.38
149 INT279524 Protein_catabolism of Adora1 1 0.88 0.34 0.38
150 INT279523 Positive_regulation of Protein_catabolism of Adora1 1 0.50 0.34 0.38
151 INT29100 Negative_regulation of Binding of ADRA2A 1 0.19 0.84 0.37
152 INT89342 Transcription of EREG 1 0.69 1.22 0.35
153 INT82763 Regulation of Positive_regulation of Egf 1 0.26 0.68 0.35
154 INT102597 Regulation of Localization of Egf 2 0.62 0.1 0.34
155 INT225248 Positive_regulation of Phosphorylation of Egf 2 0.32 2.02 0.34
156 INT13824 Transcription of Egf 6 0.56 0.94 0.33
157 INT78862 Negative_regulation of Adam17 3 0.36 1.76 0.32
158 INT72107 Positive_regulation of Protein_catabolism of Egf 2 0.16 0.34 0.32
159 INT72106 Protein_catabolism of Egf 2 0.31 0.34 0.32
160 INT29101 Positive_regulation of Transcription of ADRA2A 1 0.19 0.76 0.32
161 INT178301 Regulation of Egf 9 0.58 4.96 0.31
162 INT89339 Regulation of EREG 2 0.27 1.86 0.31
163 INT92881 Transcription of ADORA1 1 0.69 0 0.31
164 INT224100 Regulation of Negative_regulation of ADORA1 1 0.01 0.05 0.3
165 INT77294 Regulation of Gene_expression of Tgfa 1 0.59 0.27 0.3
166 INT187284 Positive_regulation of Gene_expression of Adam17 3 0.20 1.32 0.29
167 INT105246 Negative_regulation of Tgfa 1 0.07 1.08 0.29
168 INT118345 Binding of Tgfa 1 0.29 0 0.29
169 INT13453 Regulation of Negative_regulation of Adra2a 2 0.27 0.49 0.28
170 INT13818 Negative_regulation of Protein_catabolism of EGF 1 0.59 0.37 0.27
171 INT11156 Gene_expression of TGFA 4 0.61 3.03 0.26
172 INT134176 Gene_expression of ADRA2A 4 0.58 1.45 0.25
173 INT180101 Phosphorylation of Adam17 3 0.37 0.25 0.24
174 INT11155 Binding of TGFA 2 0.34 0.95 0.23
175 INT25928 Positive_regulation of Negative_regulation of ADRA2A 1 0.05 0 0.23
176 INT78865 Localization of Adam17 1 0.43 0.34 0.23
177 INT186700 Localization of Adora1 1 0.23 0 0.23
178 INT71544 Positive_regulation of Gene_expression of Tgfa 2 0.16 1.45 0.19
179 INT111291 Transcription of EGF 2 0.52 0.35 0.17
180 INT65544 Localization of TGFA 1 0.41 0.64 0.17
181 INT138679 Regulation of ADAM17 1 0.19 1.13 0.16
182 INT138680 Binding of ADAM17 1 0.36 1.42 0.16
183 INT185256 Positive_regulation of Binding of Egf 3 0.32 2.17 0.15
184 INT14870 Positive_regulation of Gene_expression of TGFA 2 0.46 2.12 0.15
185 INT27655 Transcription of Tgfa 1 0.41 0.06 0.15
186 INT249313 Negative_regulation of Gene_expression of Adora1 1 0.37 0 0.14
187 INT127623 Protein_catabolism of ADORA1 1 0.49 0.19 0.14
188 INT169349 Regulation of Adam17 1 0.37 0.97 0.13
189 INT134177 Positive_regulation of Gene_expression of ADRA2A 1 0.10 0.26 0.12
190 INT134178 Positive_regulation of Regulation of ADRA2A 1 0.10 0.24 0.12
191 INT111294 Negative_regulation of Transcription of EGF 1 0.32 0.09 0.12
192 INT138677 Negative_regulation of Transcription of ADAM17 1 0.42 1.18 0.1
193 INT187285 Protein_catabolism of Adam17 1 0.12 0.94 0.09
194 INT349818 Positive_regulation of Tgfa 1 0.20 0.22 0.09
195 INT70651 Positive_regulation of Binding of EGF 1 0.50 0.98 0.09
196 INT356064 Regulation of Negative_regulation of Adam17 1 0.23 0.24 0.08
197 INT356054 Regulation of Phosphorylation of Adam17 1 0.20 0.25 0.08
198 INT180096 Positive_regulation of Phosphorylation of Adam17 1 0.07 0 0.08
199 INT241720 Regulation of Transcription of Adora1 1 0.40 0.27 0.07
200 INT283831 Regulation of Regulation of Egf 2 0.29 1.5 0.06
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