GO:0045745

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Name positive regulation of G-protein coupled receptor protein signaling pathway
Categary Process
Go Slim No
Go Link GO:0045745
Unique Molecular Interactions 93
Total Molecular Interactions 127
Total Single Events 1113
Pain Genes Associated 8

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of G-protein coupled receptor protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of G-protein coupled receptor protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
2 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
3 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
4 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
5 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
6 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
7 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
8 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
9 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
10 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
11 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
12 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
13 INT126766 Binding of PTGDS and PTGDR2 4 0.40 1.62 0.93
14 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86
15 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
16 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
17 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
18 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
19 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
20 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
21 INT257222 Binding of Ltp and Pde5a 2 0.07 0.14 0.75
22 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
23 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
24 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62
25 INT45258 SLAMF6 Positive_regulation of Drd2 1 0.00 0 0.55
26 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
27 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
28 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
29 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
30 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
31 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.38 0 0.53
32 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
33 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
34 INT165043 Drd2 Regulation of Cck 1 0.20 0 0.52
35 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
36 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
37 INT16586 Binding of Drd2 and Nts 1 0.12 0 0.43
38 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
39 INT36009 Binding of Drd2 and Prl 1 0.01 1.05 0.42
40 INT257229 Binding of PRKG1 and Pde5a 1 0.01 0.17 0.41
41 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
42 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
43 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38
44 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
45 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
46 INT221259 Pde5a Positive_regulation of Localization of PRKG1 1 0.00 0.06 0.37
47 INT126767 Positive_regulation of Binding of PTGDS and PTGDR2 1 0.54 0.3 0.35
48 INT275094 Pde5a Regulation of Ltp 1 0.05 0 0.35
49 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
50 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
51 INT334836 Ncs1 Regulation of Drd2 1 0.02 0.48 0.33
52 INT109894 Drd2 Positive_regulation of FOS 1 0.01 0 0.33
53 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
54 INT191501 NLRP3 Positive_regulation of ECE1 1 0.01 1.09 0.28
55 INT273130 Negative_regulation of Binding of Drd2 and Hp 1 0.05 0 0.28
56 INT273129 Binding of Drd2 and Hp 1 0.04 0 0.28
57 INT97594 Penk Regulation of Gene_expression of Drd2 1 0.15 0.1 0.28
58 INT191495 NLRP3 Positive_regulation of Protein_catabolism of ECE1 1 0.01 1.09 0.28
59 INT258757 Binding of Drd2 and Rends1 1 0.00 1.26 0.25
60 INT164136 Binding of DRD2 and Prl 1 0.09 0 0.22
61 INT164135 Binding of Drd2 and Prl 1 0.04 0 0.22
62 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21
63 INT69254 Drd2 Regulation of Gene_expression of Pomc 1 0.01 0 0.2
64 INT257224 Pde5a Positive_regulation of Phosphorylation of Creb1 1 0.03 0.09 0.2
65 INT202297 Pde5a Positive_regulation of Prkg1 1 0.00 0.13 0.18
66 INT161797 Binding of ECE1 and ING1 1 0.01 0.68 0.14
67 INT324898 Ece1 Regulation of Gene_expression of Edn1 1 0.17 0.8 0.14
68 INT161795 Positive_regulation of Binding of ECE1 and ING1 1 0.02 0.68 0.14
69 INT161799 Positive_regulation of Binding of ECE1 and EDN1 1 0.07 0.68 0.14
70 INT224129 Binding of DRD2 and Adora2a 1 0.03 0.19 0.14
71 INT227956 Drd2 Regulation of Chrm2 1 0.07 0.38 0.13
72 INT227957 Chrm4 Regulation of Localization of Drd2 1 0.19 0.38 0.13
73 INT227960 Drd2 Regulation of Chrm5 1 0.26 0.38 0.13
74 INT227958 Chrm2 Regulation of Localization of Drd2 1 0.17 0.38 0.13
75 INT227959 Drd2 Regulation of Chrm4 1 0.08 0.38 0.13
76 INT202255 Binding of DRD2 and TCN1 1 0.16 0 0.12
77 INT258767 Binding of Drd2 and ADHD1 1 0.11 1.14 0.11
78 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
79 INT8046 SORT1 Negative_regulation of Drd2 1 0.00 0 0.09
80 INT257221 Negative_regulation of Binding of Src and Pde5a 1 0.03 0 0.08
81 INT257219 Binding of Src and Pde5a 1 0.02 0 0.08
82 INT258768 Drd2 Regulation of ADHD1 1 0.14 0.79 0.07
83 INT324896 Ece1 Positive_regulation of Negative_regulation of Edn1 1 0.19 0.42 0.07
84 INT244092 Binding of C2 and Drd2 1 0.01 0.06 0.07
85 INT327711 Binding of Drd2 and Uts2r 1 0.07 0.41 0.04
86 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
87 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
88 INT313871 Pde5a Positive_regulation of Pah 1 0.49 0.97 0
89 INT202571 Binding of DRD2 and DRD4 1 0.41 0.76 0
90 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
91 INT69257 Drd2 Regulation of Gene_expression of Cpe 1 0.06 0 0
92 INT69256 Drd2 Regulation of Regulation of Pomc 1 0.29 0 0
93 INT69255 Drd2 Regulation of Transcription of Pomc 1 0.29 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of G-protein coupled receptor protein signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of G-protein coupled receptor protein signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
2 INT13501 Binding of Drd2 65 0.48 23.76 35.6
3 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
4 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
5 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
6 INT12484 Binding of Drd2 45 0.48 15.17 24.72
7 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
8 INT49774 Binding of DRD2 48 0.48 17.42 20.73
9 INT209 Positive_regulation of Pde5a 30 0.21 2.54 16.31
10 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
11 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
12 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
13 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14
14 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
15 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
16 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
17 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
18 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
19 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
20 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
21 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
22 INT24460 Localization of Drd2 12 0.73 2.96 6.46
23 INT86772 Localization of Drd2 14 0.80 1.93 6.17
24 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
25 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
26 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
27 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
28 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
29 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
30 INT73128 Regulation of Pde5a 7 0.37 4.42 4.27
31 INT73127 Gene_expression of Pde5a 18 0.76 5.25 3.31
32 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
33 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
34 INT91442 Binding of PTGDR2 6 0.46 1.5 2.2
35 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
36 INT80191 Gene_expression of PTGDR2 9 0.74 4.15 2.11
37 INT108422 Binding of Pde5a 11 0.36 3.07 2.07
38 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
39 INT37294 Negative_regulation of Ece1 6 0.54 1.27 1.74
40 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
41 INT92955 Gene_expression of Ece1 5 0.74 2.2 1.36
42 INT92954 Positive_regulation of Gene_expression of Ece1 2 0.48 2.16 1.32
43 INT73126 Positive_regulation of Gene_expression of Pde5a 3 0.59 0.55 1.31
44 INT95270 Regulation of Ece1 1 0.43 2.08 1.3
45 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
46 INT15663 Regulation of Transcription of Drd2 2 0.26 0.1 1.25
47 INT77216 Localization of DRD2 3 0.75 0 1.19
48 INT87233 Gene_expression of ECE1 12 0.65 3.54 1.12
49 INT106504 Positive_regulation of PTGDR2 5 0.49 1.32 1.04
50 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
51 INT257200 Phosphorylation of Pde5a 1 0.25 0 0.94
52 INT297531 Negative_regulation of Ece1 5 0.32 5.49 0.87
53 INT11086 Regulation of Positive_regulation of Drd2 2 0.45 1.22 0.84
54 INT177532 Localization of Pde5a 2 0.56 0.96 0.81
55 INT13692 Negative_regulation of Positive_regulation of Drd2 1 0.01 0 0.79
56 INT103879 Regulation of Binding of DRD2 1 0.23 0.13 0.79
57 INT16434 Regulation of Positive_regulation of Drd2 1 0.30 0 0.78
58 INT12885 Negative_regulation of Binding of Drd2 2 0.53 0.26 0.71
59 INT326603 Regulation of Positive_regulation of DRD2 1 0.44 0.8 0.69
60 INT15662 Positive_regulation of Transcription of Drd2 3 0.39 0 0.68
61 INT268451 Positive_regulation of Gene_expression of ECE1 3 0.49 1.99 0.67
62 INT257202 Protein_catabolism of Pde5a 2 0.38 0.36 0.66
63 INT208 Negative_regulation of Positive_regulation of Pde5a 3 0.17 2.02 0.65
64 INT184840 Positive_regulation of Transcription of Drd2 2 0.35 1.03 0.65
65 INT275071 Negative_regulation of Protein_catabolism of Pde5a 1 0.17 0.36 0.6
66 INT12483 Regulation of Binding of Drd2 1 0.38 0 0.57
67 INT47933 Positive_regulation of Localization of Drd2 1 0.10 0.23 0.56
68 INT47934 Negative_regulation of Localization of Drd2 1 0.10 0.22 0.56
69 INT88705 Localization of Ece1 2 0.22 2.07 0.55
70 INT87230 Localization of ECE1 5 0.80 1.51 0.53
71 INT257211 Negative_regulation of Localization of Pde5a 1 0.13 0.2 0.48
72 INT329319 Positive_regulation of Transcription of Ece1 1 0.08 2.64 0.48
73 INT202581 Positive_regulation of Gene_expression of DRD2 2 0.49 0.81 0.47
74 INT66984 Regulation of Binding of Drd2 1 0.60 0 0.47
75 INT93926 Gene_expression of Ece1 3 0.27 2.31 0.42
76 INT324886 Transcription of Ece1 2 0.37 1.95 0.4
77 INT61124 Localization of Ece1 1 0.58 0.08 0.32
78 INT275073 Positive_regulation of Negative_regulation of Pde5a 1 0.22 0.45 0.3
79 INT191535 Protein_catabolism of ECE1 1 0.07 1.03 0.28
80 INT329320 Positive_regulation of Gene_expression of Ece1 1 0.09 1.31 0.24
81 INT326600 Negative_regulation of Gene_expression of DRD2 1 0.53 0.35 0.23
82 INT324884 Positive_regulation of Ece1 2 0.37 0.86 0.22
83 INT132961 Negative_regulation of PTGDR2 1 0.56 0 0.21
84 INT42375 Positive_regulation of Positive_regulation of Pde5a 2 0.14 0.1 0.19
85 INT324882 Regulation of Transcription of Ece1 1 0.24 0.66 0.19
86 INT126773 Negative_regulation of Gene_expression of PTGDR2 1 0.37 0.05 0.18
87 INT42376 Regulation of Positive_regulation of Pde5a 1 0.03 0 0.18
88 INT87231 Binding of ECE1 4 0.37 0.47 0.16
89 INT177528 Negative_regulation of Binding of Pde5a 1 0.34 0.46 0.15
90 INT224096 Positive_regulation of Negative_regulation of DRD2 1 0.05 0.38 0.15
91 INT161805 Positive_regulation of ECE1 1 0.12 0.61 0.13
92 INT275069 Negative_regulation of Gene_expression of Pde5a 1 0.26 0.54 0.13
93 INT87232 Regulation of ECE1 1 0.45 0.16 0.1
94 INT49260 Negative_regulation of ECE1 7 0.57 0.24 0.08
95 INT257205 Transcription of Pde5a 1 0.21 0 0.08
96 INT126436 Regulation of Gene_expression of Ece1 1 0.21 0.05 0.05
97 INT323262 Negative_regulation of Negative_regulation of Pde5a 1 0.03 1.32 0.04
98 INT255789 Protein_catabolism of Ece1 2 0.35 1.06 0
99 INT337102 Protein_catabolism of Drd2 1 0.88 0 0
100 INT263506 Regulation of Regulation of Drd2 1 0.26 0.34 0
101 INT226248 Negative_regulation of Negative_regulation of ECE1 1 0.05 0 0
102 INT311857 Positive_regulation of Gene_expression of PTGDR2 1 0.06 0.7 0
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