GO:0045746

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Name negative regulation of Notch signaling pathway
Categary Process
Go Slim No
Go Link GO:0045746
Unique Molecular Interactions 81
Total Molecular Interactions 96
Total Single Events 824
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of Notch signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of Notch signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
2 INT131256 Positive_regulation of Nfkb1 Positive_regulation of Gene_expression of Nfkbia 1 0.38 0.94 1.31
3 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
4 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
5 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
6 INT129034 Nfkbia Positive_regulation of Nfkb1 1 0.02 0.67 0.89
7 INT134311 Tnf Positive_regulation of Protein_catabolism of Nfkbia 1 0.18 0.57 0.88
8 INT187290 Binding of HEY1 and Gtf3a 1 0.00 6.18 0.83
9 INT153123 NFKBIA Negative_regulation of Phosphorylation of RELA 1 0.03 2.01 0.71
10 INT125543 Arsa Negative_regulation of Phosphorylation of Nfkbia 1 0.00 0.52 0.68
11 INT233669 gr Positive_regulation of Transcription of Nfkbia 1 0.26 0.33 0.64
12 INT329587 Binding of PTX3 and HEY1 1 0.00 2.03 0.5
13 INT87934 Phosphorylation of Nfkbia Positive_regulation of Nfkb1 1 0.02 0.1 0.45
14 INT87936 Nfkbia Positive_regulation of Nfkb1 1 0.03 0.1 0.44
15 INT207113 Nfkbia Negative_regulation of Nfkb1 1 0.11 0.96 0.4
16 INT108879 Negative_regulation of PTGS2 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.43 0.31
17 INT143724 Binding of Ikbkg and Nfkbia 1 0.02 0.79 0.29
18 INT143723 Positive_regulation of Binding of Ikbkg and Nfkbia 1 0.02 0.8 0.29
19 INT130108 DLL3 Negative_regulation of Positive_regulation of MAPK1 1 0.13 0 0.28
20 INT80873 Positive_regulation of Nfkb1 Positive_regulation of Protein_catabolism of Nfkbia 2 0.01 0.58 0.27
21 INT108878 ZNF236 Regulation of Protein_catabolism of Nfkbia 1 0.00 0.38 0.26
22 INT108880 ZNF236 Regulation of Gene_expression of Nfkbia 1 0.00 0.38 0.26
23 INT108877 ZNF236 Regulation of Phosphorylation of Nfkbia 1 0.00 0.38 0.26
24 INT108881 ZNF236 Regulation of Transcription of Nfkbia 1 0.00 0.36 0.26
25 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
26 INT144241 CGA Negative_regulation of Phosphorylation of NFKBIA 1 0.10 0.34 0.22
27 INT144244 TNF Positive_regulation of Protein_catabolism of NFKBIA 1 0.28 0.34 0.22
28 INT144253 TNF Positive_regulation of Phosphorylation of NFKBIA 1 0.39 0.34 0.22
29 INT144247 CGA Positive_regulation of Protein_catabolism of NFKBIA 1 0.11 0.34 0.22
30 INT144243 CGA Positive_regulation of Phosphorylation of NFKBIA 1 0.11 0.34 0.22
31 INT52459 Binding of SUCLA2 and HEY2 1 0.01 0.09 0.21
32 INT159788 Tnf Positive_regulation of Phosphorylation of Nfkbia 1 0.01 0.39 0.19
33 INT213551 Proc Regulation of Bmp7 1 0.00 0.15 0.14
34 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
35 INT139790 PRSS53 Negative_regulation of Phosphorylation of NFKBIA 1 0.01 0.9 0.11
36 INT306265 Binding of NFKB1 and NFKBIA 1 0.21 0.48 0.11
37 INT139789 TNFAIP8 Positive_regulation of Phosphorylation of NFKBIA 1 0.02 0.89 0.11
38 INT139788 TNFAIP8 Positive_regulation of NFKBIA 1 0.01 0.88 0.11
39 INT263449 Binding of NFKBIA and TBK1 1 0.07 0.2 0.1
40 INT263450 NFKB2 Positive_regulation of Protein_catabolism of NFKBIA 1 0.17 0.17 0.09
41 INT129624 Bmp7 Positive_regulation of Gene_expression of Id2 1 0.26 0.31 0.08
42 INT129623 Bmp7 Positive_regulation of Gene_expression of Id3 1 0.37 0.31 0.08
43 INT129625 Id2 Positive_regulation of Gene_expression of Bmp7 1 0.24 0.31 0.08
44 INT129622 Id3 Positive_regulation of Gene_expression of Bmp7 1 0.25 0.31 0.08
45 INT141997 HEY1 Negative_regulation of CDC42BPA 1 0.00 0 0.08
46 INT129627 Bmp7 Positive_regulation of Id2 1 0.24 0.25 0.07
47 INT118416 Gata2 Positive_regulation of Transcription of Tac2 1 0.27 0.2 0.07
48 INT129626 Bmp7 Positive_regulation of Id3 1 0.25 0.25 0.07
49 INT201973 Bmp7 Positive_regulation of ap 1 0.00 0.18 0.06
50 INT118462 BMP7 Regulation of Bmp7 1 0.19 0 0.06
51 INT266445 Binding of HEY1 and GOPC 1 0.00 2.92 0.04
52 INT266454 Binding of HEY1 and Acot1 1 0.00 1.19 0.04
53 INT287234 PDLIM7 Positive_regulation of Gene_expression of BMP7 1 0.14 0.12 0.03
54 INT161532 Tlr4 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.76 0.03
55 INT161531 Nfkbia Regulation of Gene_expression of Tlr4 1 0.01 0.75 0.03
56 INT161534 Tlr4 Positive_regulation of Phosphorylation of Nfkbia 1 0.00 0.77 0.03
57 INT196038 Gene_expression of Bmp7 Positive_regulation of ALPP 1 0.03 0.1 0
58 INT233401 COPD Regulation of HEY1 1 0.07 1.67 0
59 INT278752 Binding of NUP98 and HEY1 1 0.48 0 0
60 INT278773 NUP98 Regulation of HEY1 1 0.45 0 0
61 INT88409 BMP7 Positive_regulation of Gene_expression of ACTA1 1 0.09 0 0
62 INT278775 Binding of HOXA9 and HEY1 1 0.44 0 0
63 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
64 INT164909 IL33 Positive_regulation of Phosphorylation of NFKBIA 1 0.53 0.05 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of Notch signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of Notch signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT81538 Phosphorylation of Nfkbia 27 0.62 8.86 10.49
2 INT80872 Protein_catabolism of Nfkbia 28 0.92 10.56 8.62
3 INT95297 Gene_expression of Nfkbia 14 0.68 7.61 8.24
4 INT81532 Negative_regulation of Protein_catabolism of Nfkbia 21 0.54 8.92 7.38
5 INT93481 Negative_regulation of Protein_catabolism of Nfkbia 14 0.39 7.24 7.21
6 INT88498 Protein_catabolism of Nfkbia 14 0.82 6.94 7.1
7 INT81541 Negative_regulation of Nfkbia 12 0.51 5.73 6.79
8 INT148384 Positive_regulation of HEY1 19 0.43 29.76 5.89
9 INT47976 Protein_catabolism of NFKBIA 17 0.88 7.57 5.79
10 INT81535 Negative_regulation of Phosphorylation of Nfkbia 15 0.44 5.74 5.18
11 INT143234 Gene_expression of Nfkbia 10 0.62 5.2 5.02
12 INT88496 Positive_regulation of Protein_catabolism of Nfkbia 8 0.53 3.05 4.78
13 INT131253 Positive_regulation of Gene_expression of Nfkbia 4 0.41 3.28 4.71
14 INT187286 Binding of HEY1 17 0.32 31.21 4.52
15 INT176618 Gene_expression of HEY1 29 0.59 36 4.37
16 INT87210 Positive_regulation of Nfkbia 9 0.61 3.89 4.35
17 INT81543 Positive_regulation of Phosphorylation of Nfkbia 7 0.37 2.51 4.1
18 INT108868 Transcription of Nfkbia 2 0.57 2.91 4.03
19 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
20 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
21 INT137532 Negative_regulation of HEY2 1 0.31 1.69 3.18
22 INT233606 Transcription of Nfkbia 1 0.66 1.55 2.71
23 INT93401 Positive_regulation of Protein_catabolism of Nfkbia 11 0.46 3.89 2.7
24 INT107968 Positive_regulation of NFKBIA 9 0.46 5.27 2.69
25 INT47974 Negative_regulation of Protein_catabolism of NFKBIA 7 0.49 2.38 2.69
26 INT108869 Localization of Nfkbia 5 0.56 1.04 2.63
27 INT122003 Phosphorylation of NFKBIA 9 0.59 5.44 2.51
28 INT129318 Negative_regulation of NFKBIA 10 0.38 6.19 2.02
29 INT130112 Gene_expression of DLL3 1 0.25 0 2
30 INT26317 Gene_expression of NFKBIA 5 0.45 2.97 1.96
31 INT56080 Transcription of NFKBIA 2 0.40 2.16 1.93
32 INT121337 Negative_regulation of HEY1 7 0.20 12.91 1.89
33 INT151269 Positive_regulation of Localization of Nfkbia 1 0.37 0 1.86
34 INT126236 Positive_regulation of Positive_regulation of NFKBIA 4 0.46 2.18 1.69
35 INT47972 Positive_regulation of Protein_catabolism of NFKBIA 5 0.46 2.09 1.53
36 INT233612 Regulation of Transcription of Nfkbia 1 0.36 0.55 1.43
37 INT165538 Binding of Bmp7 5 0.37 1.87 1.39
38 INT87215 Localization of Nfkbia 5 0.69 1.64 1.39
39 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
40 INT233638 Positive_regulation of Transcription of Nfkbia 1 0.56 1.01 1.33
41 INT131254 Positive_regulation of Transcription of Nfkbia 1 0.36 0.99 1.28
42 INT166013 Positive_regulation of Gene_expression of NFKBIA 2 0.32 1.15 1.2
43 INT129726 Regulation of Nfkbia 2 0.06 1.63 1.05
44 INT107971 Regulation of NFKBIA 3 0.24 2.03 1.04
45 INT187289 Regulation of HEY1 5 0.39 7.8 1.03
46 INT81542 Regulation of Protein_catabolism of Nfkbia 2 0.04 0.43 1.02
47 INT143235 Positive_regulation of Gene_expression of Nfkbia 2 0.56 0.97 1.01
48 INT124198 Negative_regulation of Nfkbia 4 0.37 2.58 0.97
49 INT81540 Positive_regulation of Nfkbia 4 0.22 1.37 0.92
50 INT187288 Positive_regulation of Gene_expression of HEY1 5 0.17 8.42 0.89
51 INT143714 Phosphorylation of Nfkbia 4 0.64 2.94 0.87
52 INT143720 Negative_regulation of Phosphorylation of Nfkbia 3 0.33 2.68 0.83
53 INT159548 Regulation of Protein_catabolism of Nfkbia 1 0.18 0.62 0.82
54 INT141150 Localization of BMP7 4 0.56 2.84 0.76
55 INT233630 Regulation of Nfkbia 1 0.42 0.27 0.76
56 INT233646 Regulation of Localization of Nfkbia 1 0.42 0.27 0.76
57 INT121333 Localization of HEY1 11 0.65 18.17 0.72
58 INT95298 Negative_regulation of Gene_expression of Nfkbia 2 0.38 0.62 0.71
59 INT81533 Negative_regulation of Negative_regulation of Nfkbia 1 0.04 0.36 0.7
60 INT143719 Negative_regulation of Gene_expression of Nfkbia 2 0.43 1.31 0.68
61 INT166019 Regulation of Gene_expression of NFKBIA 1 0.05 0.64 0.65
62 INT148385 Positive_regulation of HEY2 1 0.38 1.09 0.62
63 INT100294 Positive_regulation of Gene_expression of Bmp7 8 0.46 5.41 0.61
64 INT89126 Regulation of BMP7 7 0.45 2.5 0.58
65 INT122004 Negative_regulation of Phosphorylation of NFKBIA 3 0.41 1.59 0.58
66 INT263482 Positive_regulation of Transcription of NFKBIA 1 0.39 0.61 0.57
67 INT25362 Binding of NFKBIA 4 0.26 2.52 0.55
68 INT165537 Negative_regulation of Bmp7 2 0.43 0.55 0.52
69 INT159214 Positive_regulation of Gene_expression of BMP7 6 0.46 2.16 0.51
70 INT129620 Regulation of Gene_expression of Bmp7 3 0.42 3.2 0.47
71 INT187287 Negative_regulation of Gene_expression of HEY1 2 0.16 2.96 0.45
72 INT118460 Binding of Bmp7 3 0.46 1.3 0.4
73 INT130109 Negative_regulation of Gene_expression of DLL3 1 0.14 0 0.38
74 INT130110 Regulation of Gene_expression of DLL3 1 0.20 0 0.33
75 INT196032 Positive_regulation of Gene_expression of Bmp7 10 0.17 1.31 0.31
76 INT132627 Binding of Nfkbia 1 0.03 0.41 0.31
77 INT196024 Gene_expression of Bmp7 20 0.26 1.88 0.3
78 INT126059 Positive_regulation of Gata2 1 0.02 0.87 0.28
79 INT120958 Protein_catabolism of HEY1 1 0.44 0.14 0.28
80 INT56079 Negative_regulation of Transcription of NFKBIA 1 0.05 0.54 0.26
81 INT130115 Positive_regulation of DLL3 1 0.07 0 0.25
82 INT108867 Regulation of Transcription of Nfkbia 1 0.00 0.36 0.25
83 INT244742 Gene_expression of Gata2 2 0.54 0.18 0.23
84 INT353967 Positive_regulation of Gene_expression of Gata2 1 0.42 0.18 0.23
85 INT151129 Negative_regulation of Localization of Nfkbia 1 0.30 0.31 0.19
86 INT154558 Regulation of Phosphorylation of Nfkbia 1 0.00 0.33 0.17
87 INT339267 Negative_regulation of BMP7 1 0.43 0.55 0.17
88 INT87209 Negative_regulation of Positive_regulation of Nfkbia 1 0.31 0.15 0.16
89 INT87213 Positive_regulation of Localization of Nfkbia 1 0.34 0.15 0.16
90 INT118459 Regulation of Bmp7 3 0.43 0.25 0.15
91 INT201968 Positive_regulation of Bmp7 2 0.43 1.11 0.14
92 INT139798 Positive_regulation of Phosphorylation of NFKBIA 1 0.04 0.88 0.11
93 INT266451 Regulation of Gene_expression of HEY1 1 0.02 2.03 0.09
94 INT355332 Localization of Bmp7 1 0.09 1.92 0.08
95 INT316570 Binding of BMP7 3 0.37 0.95 0.07
96 INT287244 Transcription of BMP7 1 0.66 0.15 0.07
97 INT287242 Positive_regulation of Transcription of BMP7 1 0.64 0.15 0.07
98 INT153022 Negative_regulation of Bmp7 1 0.01 0.27 0.06
99 INT201965 Transcription of Bmp7 2 0.49 0.93 0.03
100 INT277248 Localization of HEY2 1 0.73 0.5 0.03
101 INT151839 Positive_regulation of Bmp7 2 0.27 0.24 0
102 INT260766 Negative_regulation of Gene_expression of Bmp7 1 0.35 0 0
103 INT201963 Positive_regulation of Binding of Bmp7 1 0.05 0 0
104 INT314125 Regulation of Transcription of Bmp7 1 0.25 0.88 0
105 INT266450 Negative_regulation of Regulation of HEY1 1 0.02 0.72 0
106 INT314127 Regulation of Bmp7 1 0.25 0.88 0
107 INT196028 Transcription of Bmp7 1 0.18 0 0
108 INT196029 Localization of Bmp7 1 0.27 0.09 0
109 INT341052 Gene_expression of HEY2 1 0.04 0.12 0
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