GO:0045762

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Name positive regulation of adenylate cyclase activity
Categary Process
Go Slim No
Go Link GO:0045762
Unique Molecular Interactions 401
Total Molecular Interactions 653
Total Single Events 10105
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of adenylate cyclase activity. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of adenylate cyclase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69886 Ngf Positive_regulation of Calca 8 0.76 2.98 12.77
2 INT166591 Binding of CALCA and DCLK3 4 0.30 0.69 12.18
3 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
4 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
5 INT69888 Ngf Positive_regulation of Localization of Calca 4 0.52 0.51 4.95
6 INT102122 Binding of Calca and RT1-M4 7 0.29 5.83 4.94
7 INT11599 Calca Positive_regulation of Npr1 5 0.19 0.3 4.8
8 INT24742 Binding of Calca and Vip 1 0.37 0.18 4.68
9 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32
10 INT128998 Cxcl1 Positive_regulation of Localization of Calca 1 0.66 2.96 4.15
11 INT13969 Binding of Calca and Sst 3 0.32 0.6 4.02
12 INT13966 Calca Positive_regulation of Localization of Sst 5 0.49 0.75 3.91
13 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
14 INT85541 Ngf Positive_regulation of Gene_expression of Calca 2 0.55 1.84 3.71
15 INT87491 CALCA Positive_regulation of Gene_expression of IL8 1 0.72 0.92 3.52
16 INT24710 Binding of Calca and SUB1P1 1 0.01 2.09 3.48
17 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
18 INT108471 Binding of CALCA and PNOC 1 0.29 0.64 3.25
19 INT74159 Ngf Regulation of Gene_expression of Calca 2 0.60 1.66 3.22
20 INT29657 Binding of Calca and Calcb 1 0.26 0 3.16
21 INT37162 Binding of Calca and Cckar 1 0.04 0.55 3.01
22 INT100835 Binding of Calca and Akap12 1 0.07 0.41 2.92
23 INT166592 Binding of CALCA and RAMP1 2 0.35 0.33 2.91
24 INT73821 CALCA Positive_regulation of Localization of IL8 1 0.25 2.37 2.91
25 INT194409 Binding of CALCA and IGKV1D-8 1 0.15 0 2.84
26 INT169134 Binding of Calca and Trpa1 1 0.37 3.37 2.79
27 INT180779 Bdnf Regulation of Calca 1 0.09 0.23 2.71
28 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61
29 INT57624 Calca Regulation of Positive_regulation of Trh 1 0.50 0 2.53
30 INT48526 Binding of Calca and Penk 1 0.24 1.03 2.51
31 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4
32 INT13967 Calca Positive_regulation of Sst 1 0.45 0 2.3
33 INT152900 TRPV1 Regulation of Gene_expression of CALCA 1 0.69 0.73 2.29
34 INT152901 TRPV1 Regulation of Localization of CALCA 1 0.44 0.73 2.29
35 INT69887 Ngf Regulation of Calca 2 0.49 0.1 2.19
36 INT79470 Mgat4a Regulation of Localization of Calca 1 0.08 1.72 2.1
37 INT89733 Binding of Calca and Nrm 1 0.31 0.71 2.09
38 INT63873 SRPX Positive_regulation of Localization of Calca 1 0.02 0.49 2.04
39 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
40 INT26221 Calca Regulation of Gt(pU21)50Imeg 1 0.01 0 2.02
41 INT128996 Ccl2 Positive_regulation of Localization of Calca 1 0.68 1.43 2
42 INT213968 Binding of Calca and Mthfd1 1 0.05 0.16 1.99
43 INT120723 Positive_regulation of Trpv1 Positive_regulation of Localization of Calca 3 0.51 0.48 1.92
44 INT24942 Calca Regulation of TAC1 1 0.13 0.7 1.89
45 INT271408 NGF Positive_regulation of Gene_expression of CALCA 1 0.09 4.89 1.88
46 INT168723 Positive_regulation of Trpv1 Positive_regulation of Gene_expression of Calca 1 0.48 1.1 1.84
47 INT163514 Ngf Positive_regulation of Gene_expression of Calca 1 0.30 2.21 1.82
48 INT7023 Negative_regulation of Drd1a Positive_regulation of Npr1 2 0.05 0.1 1.81
49 INT24934 Calca Regulation of Nka1 3 0.05 0.43 1.73
50 INT148090 Binding of CALCA and NCOR2 1 0.00 0.65 1.71
51 INT94617 KNG1 Positive_regulation of Localization of Calca 1 0.00 0.75 1.7
52 INT70148 Drd1a Positive_regulation of Localization of Acot1 1 0.14 0 1.7
53 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68
54 INT102447 Binding of CALCA and CALCRL 2 0.26 0.33 1.67
55 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
56 INT94618 KNG1 Positive_regulation of Calca 1 0.00 0.75 1.66
57 INT144213 Nppa Positive_regulation of Localization of Calca 1 0.71 2.8 1.65
58 INT23889 Calca Positive_regulation of Localization of Tacr1 1 0.11 0.45 1.65
59 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
60 INT24157 Binding of CALCA and SFTPA1 2 0.07 0.96 1.64
61 INT122286 Prkaca Negative_regulation of Negative_regulation of Calca 1 0.12 0.54 1.63
62 INT160578 Binding of CALCA and TAC1 1 0.07 0.91 1.61
63 INT148935 Ramp1 Regulation of Calca 1 0.27 0.69 1.56
64 INT13968 Calca Negative_regulation of Positive_regulation of Sst 1 0.34 0 1.55
65 INT13970 Positive_regulation of Calca Positive_regulation of Sst 1 0.37 0 1.53
66 INT13965 Calca Positive_regulation of Positive_regulation of Sst 1 0.37 0 1.53
67 INT96784 Binding of CALCA and Calca 3 0.23 0.27 1.47
68 INT180791 Negative_regulation of Gdnf Regulation of Calca 1 0.17 0 1.47
69 INT180767 Bdnf Positive_regulation of Gene_expression of Calca 1 0.17 0 1.45
70 INT276681 Calca Regulation of Nav1 1 0.07 0.74 1.45
71 INT276686 Calca Regulation of Nav1 1 0.26 0.74 1.45
72 INT84434 Calca Negative_regulation of Negative_regulation of Hrh1 1 0.06 0.19 1.44
73 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
74 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42
75 INT144122 Binding of Calca and P2rx6 1 0.10 0 1.4
76 INT169163 Binding of Calca and Ctbs 1 0.00 0.51 1.4
77 INT51213 Vip Regulation of Localization of Calca 1 0.38 0 1.39
78 INT8719 Npy Negative_regulation of Localization of Calca 1 0.06 0.26 1.39
79 INT168724 Creb1 Negative_regulation of Gene_expression of Calca 1 0.46 1.09 1.38
80 INT168721 Positive_regulation of Creb1 Positive_regulation of Calca 1 0.53 1.07 1.37
81 INT279165 Calca Regulation of Gene_expression of Fdft1 1 0.02 0.41 1.37
82 INT180810 Gopc Positive_regulation of Calca 1 0.02 0.28 1.36
83 INT168722 Creb1 Positive_regulation of Calca 1 0.73 1.05 1.35
84 INT261463 Binding of Drd1a and Sftpd 1 0.12 0.13 1.35
85 INT151771 Binding of P2RX3 and Calca 1 0.04 0.89 1.34
86 INT298455 Calca Positive_regulation of Gene_expression of Ceacam3 1 0.17 0.47 1.34
87 INT180786 Calca Regulation of Positive_regulation of Ngf 1 0.40 0 1.32
88 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
89 INT180764 Calca Regulation of Positive_regulation of Gdnf 1 0.21 0 1.32
90 INT180807 Calca Regulation of Sorbs1 1 0.02 0 1.32
91 INT180771 Calca Regulation of Positive_regulation of Bdnf 1 0.18 0 1.32
92 INT121096 Binding of Calca and Trpv1 3 0.37 1.23 1.29
93 INT148775 Binding of Calca and Usf1 1 0.43 0.85 1.29
94 INT194408 Regulation of Binding of CALCA and DCLK3 1 0.15 0 1.29
95 INT138210 Mzb1 Regulation of Calca 1 0.25 0.41 1.29
96 INT22501 Binding of Calca and Pth 1 0.21 0.07 1.28
97 INT88635 Ptger3 Positive_regulation of Localization of Calca 2 0.05 0 1.24
98 INT136249 Drd1a Positive_regulation of Phosphorylation of Tff3 1 0.01 0.18 1.23
99 INT131195 Creb1 Positive_regulation of Positive_regulation of Drd1a 2 0.27 0.61 1.22
100 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
101 INT151454 Binding of Calca and Insrr 1 0.02 0.31 1.22
102 INT87586 RPL7AP5 Negative_regulation of Gene_expression of Calca 1 0.00 0.05 1.21
103 INT79471 Mgat4a Regulation of Calca 1 0.06 1.09 1.21
104 INT87585 RPL7AP5 Negative_regulation of Calca 1 0.00 0.05 1.21
105 INT124874 Gnat3 Positive_regulation of Localization of Calca 2 0.08 0.75 1.2
106 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19
107 INT194403 Negative_regulation of Binding of CALCA and DCLK3 1 0.22 0 1.18
108 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
109 INT91394 Negative_regulation of MMP2 Positive_regulation of CALCA 1 0.25 0.15 1.15
110 INT7024 Regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.07 1.13
111 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
112 INT22176 Calca Regulation of Localization of Prl 4 0.69 0.39 1.11
113 INT4752 Gal Negative_regulation of Localization of Calca 1 0.41 0.06 1.11
114 INT282065 Binding of Calca and Ngf 1 0.14 0.85 1.11
115 INT74185 Cck Negative_regulation of Drd1a 1 0.30 0.1 1.1
116 INT4753 Sst Negative_regulation of Localization of Calca 1 0.39 0.06 1.1
117 INT70495 CALCA Positive_regulation of CALCB 2 0.40 0 1.08
118 INT352453 Calca Positive_regulation of Trib3 1 0.00 0.8 1.08
119 INT69889 Ngf Regulation of Localization of Calca 1 0.49 0.1 1.08
120 INT352468 Calca Positive_regulation of Prkaca 1 0.11 0.8 1.08
121 INT91395 MMP2 Positive_regulation of CALCA 1 0.36 0.17 1.07
122 INT79372 Calca Regulation of Pnoc 1 0.34 0 1.07
123 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
124 INT139225 Calca Negative_regulation of Icam1 1 0.44 1.13 1.06
125 INT139229 Calca Negative_regulation of Cmklr1 1 0.19 1.12 1.06
126 INT139231 Calca Negative_regulation of Timp1 1 0.36 1.11 1.05
127 INT139226 Icam1 Negative_regulation of Calca 1 0.44 1.12 1.05
128 INT48260 Binding of Adcyap1 and Calca 1 0.35 0 1.04
129 INT130167 Trpv1 Regulation of Localization of Calca 2 0.38 0.69 1.03
130 INT86073 Med15 Regulation of Calca 1 0.49 0.2 1.03
131 INT114555 Binding of Calca and St3gal3 1 0.01 0.44 1.03
132 INT114552 Binding of Calca and Col4a4 1 0.01 0.44 1.02
133 INT51260 Calca Negative_regulation of Nts 1 0.10 0.08 1.01
134 INT51261 Calca Negative_regulation of Sst 1 0.20 0.08 1.01
135 INT7025 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.04 0.08 1.01
136 INT298298 Calca Negative_regulation of Gene_expression of Runx1 1 0.19 0.33 1
137 INT112163 Calca Positive_regulation of Mpo 1 0.49 1.23 1
138 INT298274 Gene_expression of Runx1 Negative_regulation of Calca 1 0.19 0.33 1
139 INT162299 Negative_regulation of Adarb1 Negative_regulation of Gene_expression of Calca 1 0.01 0.93 1
140 INT49163 Binding of Pax3 and Calca 1 0.03 0.37 0.98
141 INT24395 Binding of CALCA and CLPP 1 0.03 0.17 0.96
142 INT87854 Binding of Drd1a and Positive_regulation of Localization of Abat 1 0.08 0 0.96
143 INT206857 Binding of Calca and Calcrl 4 0.37 1.9 0.95
144 INT74184 Cck Regulation of Localization of Drd1a 1 0.32 0.06 0.95
145 INT148772 Usf1 Regulation of Calca 1 0.40 0.69 0.95
146 INT180787 Calca Regulation of Gdnf 1 0.18 0.28 0.95
147 INT352447 Gse1 Negative_regulation of Gene_expression of Calca 1 0.03 0.98 0.94
148 INT24938 TAC1 Regulation of Calca 1 0.22 0.35 0.94
149 INT24939 TAC3 Regulation of Calca 1 0.01 0.35 0.94
150 INT331109 Tpnr1 Regulation of Gene_expression of Calca 1 0.06 0.97 0.94
151 INT248186 Cxcl1 Positive_regulation of Localization of CALCA 1 0.39 0.88 0.93
152 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
153 INT28656 Calca Negative_regulation of Localization of Gnrhr 1 0.19 0 0.91
154 INT136172 NPY Negative_regulation of Positive_regulation of Drd1a 1 0.21 0 0.91
155 INT7292 Binding of Drd1a and Penk 1 0.14 0 0.9
156 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9
157 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89
158 INT53155 Rac1 Positive_regulation of Gene_expression of Calca 1 0.06 0 0.89
159 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
160 INT53153 fut10 Positive_regulation of Gene_expression of Calca 1 0.01 0 0.88
161 INT28655 Calca Negative_regulation of Localization of Gh1 1 0.34 0 0.88
162 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
163 INT213976 Calca Negative_regulation of Gene_expression of Il2 1 0.03 0.25 0.86
164 INT113542 Binding of Calca and Adarb1 2 0.00 0.44 0.85
165 INT351323 Nts Regulation of Localization of Calca 1 0.01 0.6 0.85
166 INT29279 Binding of Drd1a and Htr1a 1 0.35 0.2 0.84
167 INT28654 Calca Regulation of Localization of Gh1 1 0.36 0 0.84
168 INT344101 Positive_regulation of Drd1a Positive_regulation of Localization of Abat 1 0.01 0 0.84
169 INT342991 HCL1 Positive_regulation of CALCA 1 0.03 0.71 0.84
170 INT111363 TRPV1 Positive_regulation of Localization of Calca 1 0.11 0 0.83
171 INT225691 TRPV1 Positive_regulation of Localization of CALCA 1 0.18 0.7 0.83
172 INT87490 CALCA Positive_regulation of Gene_expression of CCL5 1 0.30 0.14 0.81
173 INT103178 Mastl Positive_regulation of Localization of Calca 1 0.13 0.36 0.81
174 INT87494 CALCA Positive_regulation of IL8 1 0.48 0.15 0.81
175 INT86150 Inhba Positive_regulation of Gene_expression of Calca 1 0.09 0.61 0.81
176 INT87489 CALCA Positive_regulation of Gene_expression of CCL2 1 0.43 0.14 0.81
177 INT87492 CALCA Regulation of IL8 1 0.28 0.15 0.81
178 INT213972 Calca Regulation of Mthfd1 1 0.05 0.19 0.8
179 INT109142 Calca Positive_regulation of Transcription of Creb1 1 0.47 0.13 0.8
180 INT118010 Binding of CALCA and CD177 1 0.06 0.6 0.8
181 INT131646 Ngf Positive_regulation of Localization of Calca 1 0.21 0.35 0.8
182 INT180782 Bdnf Positive_regulation of Calca 1 0.16 0.77 0.8
183 INT86151 Olr1745 Positive_regulation of Gene_expression of Calca 1 0.51 0.6 0.8
184 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
185 INT111361 Cnr1 Negative_regulation of Localization of Calca 1 0.01 0 0.78
186 INT298457 Binding of Calca and Npr1 1 0.01 0.39 0.77
187 INT96783 Positive_regulation of Binding of CALCA and Calca 1 0.29 0.17 0.77
188 INT224283 Bdnf Regulation of Gene_expression of Calca 1 0.19 0.35 0.76
189 INT353721 Negative_regulation of Binding of Drd1a and Ghsr 1 0.16 0 0.76
190 INT87493 Binding of CALCA and Positive_regulation of Gene_expression of IL8 1 0.52 0.18 0.76
191 INT109141 Calca Positive_regulation of Creb1 1 0.47 0.13 0.76
192 INT353720 Binding of Drd1a and Ghsr 1 0.18 0 0.76
193 INT262563 Negative_regulation of Pax3 Regulation of Calca 1 0.01 0.75 0.76
194 INT65593 CALCA Negative_regulation of Positive_regulation of ADCY1 1 0.23 0.07 0.76
195 INT21260 Positive_regulation of Drd1a Positive_regulation of Npr1 1 0.05 0 0.76
196 INT109143 Calca Positive_regulation of Phosphorylation of Creb1 1 0.47 0.13 0.76
197 INT125626 Binding of Calca and Atp8a2 1 0.00 0.4 0.76
198 INT262569 Pax3 Regulation of Calca 1 0.00 0.75 0.76
199 INT147619 Npr1 Positive_regulation of Localization of Calca 1 0.03 0 0.75
200 INT127876 ACE Positive_regulation of Protein_catabolism of CALCA 1 0.28 0.63 0.75

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of adenylate cyclase activity. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of adenylate cyclase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 2008 0.81 518.3 1408.65
2 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84
3 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08
4 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04
5 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38
6 INT2649 Regulation of Calca 433 0.62 146.05 330.95
7 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45
8 INT626 Localization of CALCA 289 0.81 125.39 221.15
9 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57
10 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2
11 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47
12 INT2541 Binding of Calca 200 0.48 67.14 134.62
13 INT5008 Localization of Calca 204 0.81 80.35 125.16
14 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75
15 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61
16 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03
17 INT6761 Binding of CALCA 100 0.48 26.71 62.05
18 INT4760 Negative_regulation of Gene_expression of Calca 93 0.59 34.19 60.3
19 INT4241 Regulation of CALCA 87 0.62 28.19 55.29
20 INT4891 Transcription of Calca 81 0.72 35.27 53.75
21 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66
22 INT97674 Positive_regulation of Localization of Calca 70 0.69 27.71 51.79
23 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73
24 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34
25 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8
26 INT28265 Positive_regulation of Calca 62 0.70 29.1 41.17
27 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49
28 INT8746 Negative_regulation of Calca 50 0.59 21.22 33.45
29 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76
30 INT22499 Regulation of Calca 42 0.62 17.32 28.02
31 INT13334 Gene_expression of Drd1a 43 0.62 7.73 24.43
32 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42
33 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51
34 INT7680 Regulation of Drd1a 27 0.45 4.52 18.86
35 INT51779 Gene_expression of Drd1a 46 0.66 11.18 17.51
36 INT7020 Negative_regulation of Drd1a 25 0.57 1.84 17.1
37 INT35998 Positive_regulation of Gene_expression of Calca 31 0.70 16.16 16.98
38 INT6150 Positive_regulation of Negative_regulation of Calca 20 0.68 4.06 16.26
39 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61
40 INT65109 Negative_regulation of Transcription of Calca 16 0.59 8.63 12.84
41 INT26217 Binding of Calca 22 0.48 5.22 12.57
42 INT11244 Transcription of CALCA 21 0.69 3.61 12.27
43 INT15136 Regulation of Positive_regulation of Calca 12 0.62 3.02 12.16
44 INT7682 Binding of Drd1a 22 0.48 1.8 11.83
45 INT6151 Negative_regulation of Negative_regulation of Calca 14 0.58 4.86 11.81
46 INT5779 Positive_regulation of Transcription of Calca 15 0.62 5.61 10.86
47 INT101203 Negative_regulation of Gene_expression of Calca 12 0.59 7.06 10.72
48 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86
49 INT16735 Localization of Drd1a 11 0.61 0.35 8.42
50 INT8761 Negative_regulation of Binding of Calca 12 0.43 3.59 8.32
51 INT25220 Positive_regulation of Binding of Calca 7 0.69 3.78 7.34
52 INT124264 Regulation of Localization of Calca 10 0.33 1.39 7.14
53 INT22369 Negative_regulation of Drd1a 15 0.47 6.13 6.87
54 INT21552 Regulation of Drd1a 10 0.57 3.7 6.05
55 INT52813 Regulation of Localization of CALCA 8 0.62 3.16 5.89
56 INT86982 Transcription of Calca 9 0.69 2.98 5.74
57 INT18366 Negative_regulation of Positive_regulation of Drd1a 6 0.42 0.49 5.54
58 INT157802 Negative_regulation of Timp2 7 0.54 5.75 5.51
59 INT5778 Regulation of Transcription of Calca 4 0.45 2.47 5.37
60 INT14715 Negative_regulation of Positive_regulation of CALCA 5 0.43 2.22 5.2
61 INT27261 Regulation of Regulation of Calca 7 0.45 2.8 5.08
62 INT37148 Negative_regulation of Gene_expression of CALCA 7 0.43 1.91 4.98
63 INT101925 Binding of Drd1a 9 0.43 1.82 4.97
64 INT52251 Negative_regulation of Binding of CALCA 3 0.41 0.57 4.71
65 INT68216 Binding of NF1 40 0.48 51.24 4.59
66 INT54987 Regulation of Gene_expression of Calca 6 0.62 3.44 4.59
67 INT48567 Transcription of Drd1a 7 0.51 2.44 4.54
68 INT113078 Phosphorylation of Drd1a 4 0.30 0.77 4.45
69 INT55743 Gene_expression of Timp2 25 0.31 8.95 4.3
70 INT13333 Regulation of Gene_expression of Drd1a 8 0.36 3.37 4.28
71 INT24677 Regulation of Negative_regulation of Calca 6 0.44 0.73 3.9
72 INT228465 Positive_regulation of Timp2 4 0.64 6.29 3.54
73 INT62901 Positive_regulation of Gene_expression of Drd1a 2 0.57 0.66 3.35
74 INT13335 Negative_regulation of Gene_expression of Drd1a 6 0.34 0.8 3.16
75 INT179338 Gene_expression of Timp2 7 0.55 5.75 3.13
76 INT51151 Positive_regulation of Regulation of Calca 8 0.50 1.77 3.08
77 INT18365 Positive_regulation of Regulation of Drd1a 4 0.50 1.74 3.04
78 INT27146 Negative_regulation of Regulation of Calca 4 0.43 1.18 2.9
79 INT113077 Positive_regulation of Phosphorylation of Drd1a 1 0.11 0.15 2.87
80 INT60672 Regulation of Gene_expression of CALCA 3 0.61 1.76 2.85
81 INT95720 Phosphorylation of Calca 2 0.80 2.04 2.8
82 INT57354 Positive_regulation of Positive_regulation of Calca 3 0.60 1.42 2.78
83 INT8840 Positive_regulation of Positive_regulation of CALCA 8 0.50 1.8 2.74
84 INT64248 Positive_regulation of Positive_regulation of Drd1a 6 0.45 1.97 2.62
85 INT89992 Positive_regulation of Gene_expression of Drd1a 5 0.39 2.11 2.54
86 INT19292 Protein_catabolism of CALCA 7 0.76 0.8 2.53
87 INT61434 Regulation of Nf1 3 0.26 1.39 2.4
88 INT86462 Transcription of Drd1a 3 0.44 1.86 2.36
89 INT63394 Gene_expression of Drd5 7 0.76 1.85 2.3
90 INT64700 Binding of Nf1 14 0.45 15.24 2.29
91 INT120109 Negative_regulation of Timp2 8 0.33 3.28 2.23
92 INT24407 Negative_regulation of Binding of Drd1a 3 0.25 0.81 2.18
93 INT103298 Binding of CALCR 5 0.47 6.03 2.15
94 INT58752 Positive_regulation of Binding of CALCA 3 0.49 0.73 2.09
95 INT63392 Positive_regulation of Drd5 5 0.46 1.73 2.08
96 INT152902 Positive_regulation of Transcription of CALCA 5 0.66 0.99 2.07
97 INT21046 Regulation of Positive_regulation of Drd1a 3 0.44 0.09 2.06
98 INT54986 Negative_regulation of Positive_regulation of Calca 2 0.43 0.93 2.02
99 INT13837 Negative_regulation of Positive_regulation of Drd1a 2 0.43 1.43 2.01
100 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93
101 INT24291 Positive_regulation of Negative_regulation of CALCA 3 0.61 0.67 1.91
102 INT68181 Binding of Nf1 6 0.48 8.14 1.88
103 INT215928 Binding of Timp2 1 0.23 0.79 1.66
104 INT241566 Negative_regulation of Negative_regulation of Calca 1 0.03 0.72 1.63
105 INT48300 Regulation of Binding of Calca 2 0.39 0.73 1.49
106 INT140305 Negative_regulation of Binding of Drd1a 2 0.21 0.54 1.46
107 INT113079 Regulation of Phosphorylation of Drd1a 1 0.06 0.07 1.43
108 INT52250 Positive_regulation of Regulation of CALCA 1 0.48 0.08 1.43
109 INT336571 Gene_expression of DRD5 1 0.06 0.73 1.41
110 INT78097 Negative_regulation of Regulation of CALCA 2 0.42 2.02 1.37
111 INT36588 Protein_catabolism of Calca 7 0.87 1.98 1.31
112 INT23589 Positive_regulation of CALCR 9 0.67 6.73 1.25
113 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24
114 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23
115 INT123839 Positive_regulation of Timp2 6 0.15 4.69 1.21
116 INT103859 Positive_regulation of Drd5 2 0.49 0.81 1.14
117 INT103857 Gene_expression of Drd5 2 0.23 0.92 1.08
118 INT184839 Localization of Drd1a 4 0.73 0.84 1.03
119 INT63393 Positive_regulation of Gene_expression of Drd5 3 0.49 1.21 1.02
120 INT95719 Negative_regulation of Phosphorylation of Calca 1 0.41 0.09 1.02
121 INT95718 Positive_regulation of Phosphorylation of Calca 1 0.49 0.09 1.01
122 INT77054 Regulation of Gene_expression of Timp2 2 0.05 0.7 0.96
123 INT64690 Negative_regulation of Localization of Drd1a 2 0.09 0 0.95
124 INT74183 Positive_regulation of Localization of Drd1a 1 0.32 0.06 0.95
125 INT85999 Binding of Drd5 2 0.27 0.84 0.94
126 INT99668 Positive_regulation of Binding of Drd1a 2 0.43 0.89 0.87
127 INT54985 Positive_regulation of Regulation of Calca 2 0.47 0.33 0.86
128 INT134654 Localization of CALCR 5 0.39 3.21 0.85
129 INT55742 Positive_regulation of Gene_expression of Timp2 2 0.08 1.81 0.82
130 INT97673 Protein_catabolism of Calca 1 0.50 0.15 0.82
131 INT342616 Regulation of Timp2 1 0.56 1.75 0.81
132 INT39820 Gene_expression of CALCR 16 0.37 4.96 0.74
133 INT23590 Regulation of CALCR 4 0.26 1.05 0.71
134 INT300588 Regulation of Drd5 1 0.32 0.67 0.69
135 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68
136 INT324890 Negative_regulation of Negative_regulation of Timp2 2 0.40 1.09 0.68
137 INT179133 Localization of Nf1 2 0.80 2.18 0.68
138 INT184846 Negative_regulation of Drd5 1 0.19 2.28 0.68
139 INT49650 Gene_expression of Nf1 4 0.76 3.38 0.67
140 INT153157 Regulation of Regulation of Drd1a 2 0.25 0.2 0.66
141 INT184848 Positive_regulation of Transcription of Drd1a 1 0.26 0.93 0.65
142 INT140306 Regulation of Binding of Drd1a 1 0.20 0.36 0.64
143 INT72516 Regulation of Binding of Drd1a 2 0.44 0.4 0.63
144 INT72911 Positive_regulation of Negative_regulation of Calca 1 0.43 0.07 0.63
145 INT103858 Regulation of Gene_expression of Drd5 1 0.08 0.92 0.58
146 INT342612 Positive_regulation of Positive_regulation of Timp2 1 0.43 1.05 0.57
147 INT127878 Negative_regulation of Positive_regulation of Timp2 1 0.07 1.12 0.57
148 INT59481 Negative_regulation of Negative_regulation of CALCA 2 0.43 0.08 0.54
149 INT157718 Binding of DRD5 1 0.33 0.57 0.52
150 INT61992 Positive_regulation of Gene_expression of NF1 3 0.50 4.47 0.51
151 INT139666 Binding of Timp2 3 0.13 0.55 0.5
152 INT316933 Transcription of Nf1 1 0.18 0.49 0.47
153 INT316939 Positive_regulation of Transcription of Nf1 1 0.16 0.49 0.47
154 INT139667 Transcription of Timp2 2 0.17 0.45 0.43
155 INT344086 Binding of Drd5 1 0.36 0.06 0.37
156 INT48566 Regulation of Transcription of Drd1a 1 0.32 0 0.37
157 INT242545 Regulation of Regulation of Calca 1 0.15 0 0.36
158 INT233109 Regulation of Positive_regulation of CALCA 1 0.30 0.23 0.36
159 INT269822 Transcription of Timp2 1 0.36 1.43 0.36
160 INT112334 Regulation of NF1 18 0.52 15.85 0.34
161 INT204941 Protein_catabolism of Timp2 1 0.03 0.35 0.32
162 INT317974 Localization of Timp2 1 0.38 0.88 0.3
163 INT300593 Regulation of Gene_expression of Drd5 1 0.33 0.13 0.28
164 INT136052 Negative_regulation of Negative_regulation of Drd1a 1 0.13 0.66 0.27
165 INT129342 Positive_regulation of Positive_regulation of Nf1 1 0.50 0.79 0.23
166 INT68180 Regulation of Nf1 2 0.27 2.02 0.22
167 INT124486 Regulation of Negative_regulation of CALCA 1 0.16 0.21 0.21
168 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2
169 INT129341 Negative_regulation of Gene_expression of Nf1 2 0.43 1.67 0.2
170 INT324889 Positive_regulation of Gene_expression of Timp2 1 0.17 0.55 0.2
171 INT45800 Phosphorylation of CALCA 2 0.67 0.64 0.18
172 INT61468 Negative_regulation of CALCR 4 0.42 0.27 0.17
173 INT191797 Negative_regulation of Gene_expression of CALCR 2 0.03 1.37 0.17
174 INT155285 Positive_regulation of Nf1 1 0.16 0.55 0.17
175 INT103196 Negative_regulation of Gene_expression of Nf1 1 0.57 1.21 0.16
176 INT153941 Localization of Timp2 2 0.58 0.07 0.1
177 INT329791 Negative_regulation of Protein_catabolism of Calca 1 0.21 1.17 0.1
178 INT180707 Regulation of Localization of Timp2 1 0.35 0 0.1
179 INT61991 Negative_regulation of Gene_expression of NF1 1 0.59 1.67 0.08
180 INT190026 Positive_regulation of Gene_expression of Nf1 3 0.53 2.45 0.07
181 INT72030 Regulation of Binding of CALCA 2 0.54 0.65 0.07
182 INT223763 Negative_regulation of DRD5 1 0.01 0.06 0.06
183 INT180695 Regulation of Timp2 2 0.21 0.67 0.05
184 INT191796 Positive_regulation of Gene_expression of CALCR 2 0.06 1.74 0.05
185 INT61469 Transcription of CALCR 3 0.43 1.37 0.04
186 INT213679 Positive_regulation of Transcription of CALCR 1 0.30 1.37 0.04
187 INT169558 Positive_regulation of NF1 13 0.59 13.58 0
188 INT112333 Localization of NF1 2 0.51 0.63 0
189 INT216268 Positive_regulation of Positive_regulation of NF1 2 0.40 2.08 0
190 INT299138 Regulation of Positive_regulation of Timp2 1 0.12 0.26 0
191 INT149110 Regulation of Negative_regulation of Calca 1 0.18 0.08 0
192 INT167476 Negative_regulation of Transcription of CALCA 1 0.55 0.7 0
193 INT286141 Negative_regulation of Negative_regulation of NF1 1 0.01 0.66 0
194 INT237279 Regulation of Binding of NF1 1 0.38 0.79 0
195 INT177934 Regulation of Gene_expression of NF1 1 0.19 1.23 0
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