GO:0045780

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Name positive regulation of bone resorption
Categary Process
Go Slim No
Go Link GO:0045780
Unique Molecular Interactions 653
Total Molecular Interactions 953
Total Single Events 8151
Pain Genes Associated 24

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of bone resorption. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of bone resorption. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
2 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
3 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
4 INT296277 Binding of Car2 and Kcnip3 5 0.18 1.09 2.06
5 INT296280 Binding of Car2 and Dlg4 1 0.19 0.45 1.71
6 INT45816 Binding of Car2 and Gabrg1 2 0.28 0.15 1.63
7 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55
8 INT208980 Binding of Ca2 and Trpv1 4 0.32 0.67 1.55
9 INT256360 Car2 Positive_regulation of Localization of Rela 1 0.14 0 1.51
10 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 0.04 0.66 1.49
11 INT293013 IL8 Positive_regulation of Positive_regulation of CA2 1 0.12 0.66 1.49
12 INT3573 Tf Negative_regulation of Localization of Gh1 1 0.36 0 1.49
13 INT264327 IL-17 Positive_regulation of Gene_expression of Tnfsf11 1 0.07 3.19 1.33
14 INT285185 Binding of Ca2 and Cd2 1 0.25 0.24 1.21
15 INT110435 Positive_regulation of Grm8 Positive_regulation of Localization of Ca2 1 0.38 0 1.21
16 INT317553 Binding of Car2 and Grin1 1 0.07 0 1.14
17 INT81788 Binding of AGRP and MC4R 4 0.51 0 1.09
18 INT331108 Mc1r Positive_regulation of Mc4r 1 0.44 1.05 1.06
19 INT317552 Binding of Calm3 and Car2 2 0.06 0.07 1.05
20 INT293014 IRF6 Positive_regulation of Localization of CA2 1 0.04 0.71 1.02
21 INT293008 IL8 Positive_regulation of Localization of CA2 1 0.11 0.71 1.01
22 INT353690 Binding of Grin2b and Ca2 1 0.14 1.17 1.01
23 INT69506 CA2 Positive_regulation of PRKCA 1 0.50 0.42 0.98
24 INT48341 Negative_regulation of Pde8a Regulation of Ahsg 1 0.22 0 0.9
25 INT48342 Pde8a Regulation of Ahsg 1 0.24 0 0.9
26 INT209881 Binding of TNFRSF11B and TNFSF11 8 0.36 8.92 0.86
27 INT182636 Binding of TNFSF11 and TNFRSF11A 16 0.29 17.5 0.84
28 INT110118 A630055G03Rik Regulation of Car2 1 0.01 0.35 0.81
29 INT270217 Binding of C2 and Ca2 1 0.03 1.63 0.81
30 INT251172 Trpv1 Regulation of Gene_expression of Ca2 1 0.13 0.7 0.81
31 INT296279 Positive_regulation of Rbm39 Positive_regulation of Positive_regulation of Car2 1 0.01 0.58 0.78
32 INT187229 Binding of Tnfsf11 and Insrr 1 0.00 2.06 0.78
33 INT207391 Il17a Positive_regulation of Gene_expression of Tnfsf11 2 0.05 1.19 0.77
34 INT296297 Positive_regulation of Cysltr1 Positive_regulation of Positive_regulation of Car2 1 0.01 0.59 0.77
35 INT136795 Spp1 Positive_regulation of Chuk 1 0.11 1.54 0.77
36 INT170369 Binding of Car2 and Nono 1 0.01 0 0.76
37 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
38 INT322128 Binding of Ca2 and Trpv4 1 0.03 1.1 0.75
39 INT111080 Binding of CA1 and CA2 2 0.02 1.62 0.73
40 INT136538 Nrgn Regulation of Car2 1 0.33 0 0.73
41 INT272147 PTAFR Positive_regulation of CA2 1 0.13 0 0.71
42 INT187231 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.18 1.8 0.71
43 INT208978 Ca2 Positive_regulation of Trpv1 1 0.22 0.29 0.71
44 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7
45 INT772 Tf Positive_regulation of Positive_regulation of Oprl1 1 0.11 0 0.7
46 INT778 Tf Positive_regulation of Gh1 1 0.14 0 0.7
47 INT782 Tf Positive_regulation of Prl 1 0.43 0 0.7
48 INT251169 Clu Regulation of Ca2 1 0.03 0.66 0.7
49 INT335596 Positive_regulation of Grin2b Positive_regulation of Positive_regulation of Car2 1 0.12 0.19 0.69
50 INT187220 Il11 Positive_regulation of Gene_expression of Tnfsf11 1 0.13 0.86 0.69
51 INT185802 Binding of MMP7 and SPP1 1 0.33 1.71 0.68
52 INT283049 Car2 Positive_regulation of Trpa1 1 0.20 1.33 0.67
53 INT308484 Car2 Positive_regulation of Pla2g4a 1 0.03 1.23 0.65
54 INT251165 Trpv1 Positive_regulation of Gene_expression of Ca2 1 0.15 0.54 0.65
55 INT235082 CA2 Positive_regulation of NOS1 2 0.11 0.62 0.63
56 INT326193 Bdnf Positive_regulation of Car2 2 0.14 0.11 0.62
57 INT121873 Creb1 Regulation of Phosphorylation of Car2 1 0.10 0 0.62
58 INT50816 Penk Positive_regulation of Localization of Ca2 1 0.32 0 0.62
59 INT123301 Car2 Positive_regulation of Creb1 1 0.21 0.28 0.61
60 INT70254 Binding of Htr1a and Ca2 1 0.31 0.5 0.6
61 INT40901 Trf Regulation of Localization of POMC 1 0.07 0.56 0.6
62 INT275063 CA2 Positive_regulation of Positive_regulation of CAMK4 1 0.01 0 0.59
63 INT240070 KCNIP3 Regulation of CA2 1 0.02 0.72 0.59
64 INT185809 Binding of PDX1 and SPP1 1 0.02 1.69 0.57
65 INT209885 TNFSF11 Positive_regulation of TNFRSF11A 3 0.56 3.41 0.55
66 INT108021 Binding of Pomc and Mc4r 1 0.00 0.97 0.55
67 INT254279 Il13 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
68 INT254280 Il4 Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.79 0.54
69 INT209591 Car2 Positive_regulation of Positive_regulation of Ltp 1 0.05 0 0.54
70 INT208984 Binding of Ca2 and Fig4 1 0.02 0 0.54
71 INT209592 Car2 Positive_regulation of Localization of Ltp 1 0.05 0 0.54
72 INT216918 Binding of Ca2 and Abat 1 0.01 0.45 0.53
73 INT118138 Binding of Ca2 and Mgat4a 1 0.01 0 0.53
74 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
75 INT214164 Binding of Mc4r and Pomc 1 0.39 1.31 0.53
76 INT297479 Ryr2 Positive_regulation of Ca2 1 0.22 0 0.52
77 INT207396 IL6 Positive_regulation of Gene_expression of Tnfsf11 1 0.03 0.95 0.51
78 INT318472 CA2 Regulation of OPRM1 1 0.17 0 0.51
79 INT187227 Vip Negative_regulation of Gene_expression of Tnfsf11 1 0.35 1.23 0.51
80 INT207394 IL1B Positive_regulation of Gene_expression of Tnfsf11 1 0.05 0.95 0.51
81 INT89186 Agrp Negative_regulation of Mc4r 1 0.40 0 0.51
82 INT130335 Binding of Mc4r and Nr3c2 1 0.06 1.87 0.5
83 INT330796 P2ry1 Positive_regulation of Ca2 1 0.05 0.06 0.5
84 INT185800 SPP1 Negative_regulation of Gene_expression of MMP1 1 0.26 1.03 0.49
85 INT207395 TNF Regulation of Gene_expression of Tnfsf11 1 0.11 0.91 0.49
86 INT231732 Negative_regulation of Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
87 INT250077 Positive_regulation of Ltp Positive_regulation of Localization of Ca2 1 0.10 0 0.48
88 INT231733 Binding of Tnfrsf11a and Tnfsf11 1 0.01 1.03 0.48
89 INT237810 Itpr3 Positive_regulation of Localization of Car2 2 0.08 0.68 0.45
90 INT261839 Binding of Car2 and Trpv1 1 0.03 0 0.45
91 INT346914 Binding of Kars and Positive_regulation of Gene_expression of Car2 1 0.05 1.24 0.45
92 INT265359 Efs Positive_regulation of Car2 1 0.19 0.42 0.45
93 INT259208 Ca2 Positive_regulation of Phosphorylation of Creb1 1 0.04 0 0.45
94 INT254460 Binding of Calm2 and Ca2 5 0.03 0.48 0.43
95 INT346130 Il17a Positive_regulation of Gene_expression of TNFSF11 1 0.08 0.61 0.41
96 INT291449 Car2 Positive_regulation of SK 1 0.03 0 0.39
97 INT288700 Binding of Cp and Tfrc 1 0.40 0 0.39
98 INT334662 Ltp Regulation of Car2 1 0.09 0.22 0.39
99 INT15028 NA Positive_regulation of Localization of Ca2 1 0.04 0 0.39
100 INT201274 Car2 Regulation of Gene_expression of Nos1 1 0.05 1.15 0.38
101 INT185811 SPP1 Positive_regulation of MMP3 1 0.14 0.83 0.38
102 INT185814 Binding of MMP3 and SPP1 1 0.15 0.83 0.38
103 INT272148 PTAFR Regulation of Localization of CA2 1 0.14 0 0.38
104 INT235083 CA2 Positive_regulation of Gene_expression of CALM1 1 0.01 0.63 0.37
105 INT185804 MMP2 Positive_regulation of SPP1 1 0.15 0.88 0.37
106 INT185795 MMP7 Positive_regulation of SPP1 1 0.38 0.81 0.37
107 INT214142 Agrp Positive_regulation of Mc4r 1 0.39 0.23 0.37
108 INT214145 Binding of Agrp and Mc4r 1 0.40 0.18 0.37
109 INT33862 Ca2 Positive_regulation of Positive_regulation of Sult1b1 1 0.07 0.07 0.37
110 INT185798 SPP1 Positive_regulation of Gene_expression of MMP2 1 0.26 0.87 0.37
111 INT320591 Ca2 Positive_regulation of Nos1 1 0.07 0.09 0.37
112 INT263226 Prkcg Negative_regulation of Positive_regulation of Ca2 1 0.01 0.58 0.36
113 INT185807 SPP1 Positive_regulation of MMP7 1 0.56 0.79 0.36
114 INT26168 Car2 Positive_regulation of Hrasls 1 0.10 0 0.36
115 INT133307 Binding of CD44 and SPP1 5 0.26 2.6 0.35
116 INT309192 Binding of Car2 and Rbms1 1 0.05 0 0.34
117 INT210597 Negative_regulation of Binding of TNFSF11 and TNFRSF11A 3 0.26 5.66 0.33
118 INT353689 Binding of Slc8a1 and Ca2 1 0.15 0.58 0.33
119 INT165764 Tnfsf11 Positive_regulation of Mapk3 1 0.17 1.08 0.33
120 INT241966 Binding of Ca2 and Acpt 1 0.06 0.06 0.33
121 INT322129 Binding of Prkcg and Ca2 1 0.00 0.57 0.33
122 INT322133 Trpv4 Regulation of Ca2 1 0.04 0.16 0.33
123 INT34449 Binding of Ca2 and Pck1 1 0.17 0.18 0.33
124 INT242995 Agt Positive_regulation of Spp1 1 0.36 1.82 0.33
125 INT165765 Tnfsf11 Positive_regulation of Nfkb1 1 0.01 1.07 0.33
126 INT165763 Tnfsf11 Positive_regulation of Phosphorylation of Mapk3 1 0.40 1.08 0.33
127 INT317566 Car2 Positive_regulation of Camk2a 2 0.19 0.58 0.32
128 INT282420 Spp1 Positive_regulation of Ins1 1 0.20 1.25 0.32
129 INT195146 Cpm Regulation of Localization of CA2 1 0.00 0.22 0.32
130 INT187223 Il1 Positive_regulation of Gene_expression of Tnfsf11 1 0.09 0.64 0.32
131 INT188804 S100a8 Positive_regulation of Gene_expression of Tnfsf11 1 0.00 0.7 0.31
132 INT127974 RAX2 Positive_regulation of SPP1 1 0.03 1.49 0.31
133 INT241971 Ca2 Regulation of Localization of Abat 1 0.01 0 0.31
134 INT317557 Calm3 Positive_regulation of Car2 1 0.05 0 0.31
135 INT144500 CCL3 Positive_regulation of Gene_expression of Tnfsf11 1 0.77 1.62 0.31
136 INT232614 Positive_regulation of Car2 Positive_regulation of Cysltr1 1 0.01 0.62 0.31
137 INT232616 Car2 Positive_regulation of Cysltr1 1 0.02 0.62 0.31
138 INT75042 Binding of MC2R and MC4R 1 0.00 0.18 0.3
139 INT224422 Regulation of Binding of NFKB2 and TNFSF11 1 0.13 0.69 0.3
140 INT156261 Negative_regulation of Binding of Oxt and Ca2 1 0.16 0.12 0.3
141 INT26738 Ca2 Positive_regulation of Localization of Ins1 1 0.12 0.09 0.3
142 INT140386 Spp1 Positive_regulation of NFKB1 1 0.21 1.29 0.3
143 INT224418 Binding of NFKB2 and TNFSF11 1 0.11 0.68 0.3
144 INT261047 MZB1 Positive_regulation of Positive_regulation of CA2 1 0.02 0.09 0.3
145 INT140385 Spp1 Negative_regulation of FOXO3 1 0.04 1.29 0.3
146 INT156262 Binding of Oxt and Ca2 1 0.14 0.12 0.3
147 INT185799 Binding of EGFR and SPP1 1 0.19 0.64 0.29
148 INT209233 Tg(Ngf)47Kma Regulation of Car2 1 0.01 0.1 0.28
149 INT185813 Binding of MMP7 and Positive_regulation of SPP1 1 0.46 0.85 0.28
150 INT209232 Tg(Ngf)47Kma Regulation of Localization of Car2 1 0.02 0.1 0.28
151 INT185818 SPP1 Positive_regulation of Gene_expression of COL7A1 1 0.10 0.82 0.28
152 INT154834 Stim1 Regulation of Regulation of Ca2 1 0.13 0.9 0.28
153 INT344402 Binding of Crp and Spp1 1 0.05 2.92 0.28
154 INT189200 Binding of CA2 and ITPR3 3 0.03 1.9 0.27
155 INT3577 Tf Negative_regulation of Positive_regulation of Gh1 1 0.49 0 0.27
156 INT305623 Ca2 Positive_regulation of Cabin1 1 0.00 0.27 0.27
157 INT322127 Binding of Mbp and Ca2 1 0.01 0.39 0.27
158 INT323147 Binding of CA2 and DBT 1 0.01 0.17 0.26
159 INT250461 Binding of Car2 and Ba2 1 0.01 0 0.26
160 INT272174 Acot1 Regulation of Ca2 1 0.01 0 0.26
161 INT242991 Agt Positive_regulation of Gene_expression of Spp1 1 0.21 0.66 0.26
162 INT35022 Ptz1b Positive_regulation of Ca2 1 0.01 0 0.25
163 INT35020 Regulation of Ptz1b Positive_regulation of Ca2 1 0.01 0 0.25
164 INT209230 Positive_regulation of Car2 Positive_regulation of Ltp 1 0.04 0.12 0.25
165 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24
166 INT283028 Nav1 Regulation of Ca2 1 0.08 0 0.24
167 INT283027 Pirt Regulation of Ca2 1 0.00 0 0.24
168 INT130691 CA2 Positive_regulation of EIF2AK3 1 0.16 0.59 0.24
169 INT130714 CA2 Positive_regulation of Eif2s1 1 0.16 0.59 0.24
170 INT136798 Spp1 Regulation of Gene_expression of PTGS2 1 0.08 0.65 0.24
171 INT52585 RPL35AP35 Positive_regulation of Positive_regulation of Ca2 1 0.00 0.34 0.24
172 INT130689 CA2 Positive_regulation of ATF4 1 0.13 0.59 0.24
173 INT329311 Spp1 Positive_regulation of IFN1@ 1 0.20 1.2 0.23
174 INT337892 Positive_regulation of Mc4r Positive_regulation of Gene_expression of Nr2f2 1 0.34 0 0.23
175 INT330797 Positive_regulation of Accn2 Positive_regulation of Ca2 1 0.03 0 0.23
176 INT268946 Ros1 Regulation of Gene_expression of Ca2 1 0.00 0.18 0.23
177 INT191480 Htr3a Positive_regulation of Ca2 1 0.02 0.12 0.23
178 INT329306 Spp1 Positive_regulation of Il12a 1 0.08 1.19 0.23
179 INT309751 Binding of CA2 and TRPV4 1 0.08 0 0.23
180 INT265360 Binding of Car2 and Daf2 1 0.18 0.09 0.22
181 INT299155 Smcp Negative_regulation of Spp1 1 0.00 0.7 0.22
182 INT89238 Positive_regulation of RUNX1 Positive_regulation of Positive_regulation of CA2 1 0.01 0 0.22
183 INT248173 Car2 Positive_regulation of GRIN1 1 0.08 0 0.22
184 INT353691 Slc8a1 Positive_regulation of Ca2 1 0.18 0.45 0.22
185 INT330546 Positive_regulation of Trpm8 Positive_regulation of Positive_regulation of Ca2 1 0.13 0.67 0.22
186 INT264778 Binding of CA2 and Gabbr1 1 0.02 0 0.21
187 INT80620 CA2 Regulation of KCNIP3 1 0.11 0.08 0.21
188 INT301279 Tnfsf11 Regulation of Gene_expression of Mmp9 1 0.13 0.34 0.21
189 INT242994 Adipoq Negative_regulation of Spp1 1 0.19 0.59 0.21
190 INT171973 Tnfsf11 Positive_regulation of Gene_expression of Il1 1 0.06 0.21 0.21
191 INT171972 Tnfsf11 Positive_regulation of Gene_expression of Il6 1 0.08 0.21 0.21
192 INT301281 Tnfsf11 Regulation of Gene_expression of Clec5a 1 0.22 0.34 0.21
193 INT188801 Il6 Positive_regulation of Positive_regulation of Tnfsf11 1 0.06 0.46 0.21
194 INT261048 CHR Positive_regulation of CA2 1 0.03 0.21 0.21
195 INT190745 Adcyap1 Regulation of Car2 1 0.08 0 0.21
196 INT234992 Car2 Positive_regulation of Jup 1 0.02 0.27 0.2
197 INT290855 PPR Regulation of Ca2 1 0.01 0.45 0.2
198 INT151424 Tfrc Negative_regulation of Positive_regulation of Tnni3 1 0.21 0.98 0.2
199 INT235014 Car2 Positive_regulation of DSP 1 0.06 0.28 0.2
200 INT301290 Tnfsf11 Positive_regulation of Nfatc1 1 0.15 0.65 0.2

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of bone resorption. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of bone resorption. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64
2 INT4822 Localization of Ca2 417 0.80 99.57 96.45
3 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35
4 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71
5 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01
6 INT1032 Regulation of Ca2 202 0.52 54.91 53.03
7 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76
8 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97
9 INT17561 Localization of Car2 303 0.79 60.95 44.52
10 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66
11 INT5489 Localization of CA2 172 0.80 39.46 33.56
12 INT110427 Gene_expression of Spp1 199 0.78 176.11 23.31
13 INT17962 Regulation of Car2 124 0.41 33.98 22.71
14 INT23564 Negative_regulation of Car2 103 0.50 27.28 21.86
15 INT23533 Gene_expression of CA2 110 0.75 30.81 19.4
16 INT64442 Regulation of Mc4r 6 0.62 5.22 19.09
17 INT14546 Positive_regulation of Localization of Ca2 93 0.67 31.09 18.72
18 INT64447 Transcription of Mc4r 14 0.61 6.08 15.29
19 INT113625 Positive_regulation of Gene_expression of Ca2 47 0.50 9.82 14.07
20 INT19799 Binding of Ca2 71 0.48 13.69 12.92
21 INT64445 Gene_expression of Mc4r 17 0.78 5.06 12.91
22 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35
23 INT119400 Phosphorylation of Car2 19 0.52 8.47 11.63
24 INT37541 Gene_expression of SPP1 113 0.77 68.54 11.35
25 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24
26 INT85017 Positive_regulation of Mc4r 13 0.67 7.56 10.86
27 INT3535 Regulation of CA2 61 0.32 16.48 10.8
28 INT89184 Gene_expression of Mc4r 55 0.77 23.85 10.65
29 INT93533 Positive_regulation of Tnfsf11 53 0.50 36.93 10.53
30 INT130867 Gene_expression of TNFSF11 106 0.77 45.15 10.34
31 INT29967 Positive_regulation of Positive_regulation of Car2 40 0.40 8.03 10.13
32 INT33094 Regulation of Localization of Ca2 28 0.38 8.65 9.96
33 INT23535 Positive_regulation of Localization of CA2 41 0.41 13.52 9.43
34 INT23094 Positive_regulation of Positive_regulation of Ca2 29 0.49 6.8 9.35
35 INT1129 Binding of Car2 69 0.35 14.01 9.2
36 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52
37 INT170504 Positive_regulation of Gene_expression of Car2 60 0.41 19.1 8.45
38 INT64449 Negative_regulation of Gene_expression of Mc4r 7 0.58 2 7.86
39 INT122901 Positive_regulation of Spp1 67 0.67 58.03 7.49
40 INT119729 Binding of Tnfsf11 31 0.35 24.02 7.45
41 INT104207 Positive_regulation of Gene_expression of Tnfsf11 43 0.69 25.8 7.35
42 INT19366 Negative_regulation of Localization of Ca2 33 0.50 6.51 6.61
43 INT195145 Positive_regulation of Gene_expression of CA2 25 0.37 7.2 6.59
44 INT64444 Negative_regulation of Mc4r 9 0.58 5.12 6.44
45 INT122902 Positive_regulation of Gene_expression of Spp1 54 0.70 56.3 6.33
46 INT136555 Negative_regulation of Tnfsf11 31 0.55 22.23 6.23
47 INT5490 Binding of CA2 52 0.36 9.73 5.53
48 INT149739 Regulation of Gene_expression of Ca2 25 0.38 7.22 5.53
49 INT88935 Positive_regulation of SPP1 36 0.70 31.07 5.49
50 INT170516 Negative_regulation of Gene_expression of Car2 35 0.35 9.4 5.48
51 INT22160 Negative_regulation of Positive_regulation of Car2 18 0.38 4.94 5.45
52 INT74051 Negative_regulation of Localization of Car2 27 0.38 9.58 5.1
53 INT105609 Negative_regulation of Mc4r 10 0.58 10.4 5.04
54 INT6983 Negative_regulation of Positive_regulation of Ca2 18 0.41 4.29 5.03
55 INT64446 Negative_regulation of Transcription of Mc4r 4 0.43 1.01 4.8
56 INT64441 Regulation of Transcription of Mc4r 3 0.27 2.93 4.62
57 INT12194 Gene_expression of Trf 38 0.69 18.1 4.56
58 INT11565 Gene_expression of Tf 24 0.68 5.89 4.36
59 INT76467 Regulation of Gene_expression of Car2 41 0.37 12.88 4.21
60 INT134646 Gene_expression of Tnfsf11 19 0.69 14.77 4.16
61 INT97128 Localization of SPP1 32 0.80 21.75 4.02
62 INT129746 Positive_regulation of Gene_expression of Tfrc 4 0.18 2.15 3.74
63 INT76468 Regulation of Positive_regulation of Car2 13 0.29 4.54 3.46
64 INT136791 Negative_regulation of Spp1 24 0.59 23.6 3.33
65 INT15801 Positive_regulation of TFRC 11 0.33 6.35 3.3
66 INT66599 Gene_expression of MC4R 16 0.78 12.37 3.12
67 INT88130 Gene_expression of Spp1 13 0.74 12.96 3.07
68 INT68846 Gene_expression of Tfrc 22 0.32 10.1 3.06
69 INT210838 Positive_regulation of Mc4r 17 0.53 6.79 3.06
70 INT130865 Positive_regulation of TNFSF11 29 0.69 12.82 2.99
71 INT15549 Regulation of Positive_regulation of Ca2 11 0.38 2.55 2.92
72 INT91520 Negative_regulation of Positive_regulation of CA2 7 0.30 0.99 2.92
73 INT46650 Localization of Trf 13 0.61 4.4 2.91
74 INT93531 Negative_regulation of Gene_expression of Tnfsf11 15 0.43 7.74 2.84
75 INT2042 Phosphorylation of Ca2 21 0.55 1.54 2.81
76 INT132846 Localization of Tnfsf11 17 0.69 10.28 2.78
77 INT130028 Positive_regulation of Gene_expression of Mc4r 2 0.45 0.41 2.7
78 INT70253 Negative_regulation of Gene_expression of Ca2 29 0.49 16.31 2.69
79 INT17033 Positive_regulation of Trf 21 0.62 11.76 2.68
80 INT196870 Positive_regulation of Phosphorylation of Car2 6 0.26 3.43 2.63
81 INT51753 Negative_regulation of Tfrc 7 0.41 3.47 2.62
82 INT93562 Negative_regulation of Localization of CA2 15 0.59 1.87 2.51
83 INT81989 Positive_regulation of Tnfsf11 11 0.54 7.57 2.4
84 INT144490 Regulation of Gene_expression of Tnfsf11 14 0.58 14.09 2.39
85 INT93532 Regulation of Tnfsf11 14 0.42 10.75 2.39
86 INT210833 Regulation of Mc4r 4 0.30 1.57 2.38
87 INT21726 Gene_expression of Tfrc 10 0.74 7.38 2.36
88 INT176517 Negative_regulation of Gene_expression of Spp1 18 0.59 15.31 2.28
89 INT72743 Positive_regulation of Negative_regulation of Ca2 4 0.49 1.41 2.11
90 INT278340 Gene_expression of Syk 7 0.51 4.92 2.09
91 INT82543 Negative_regulation of Gene_expression of TFRC 4 0.57 1.27 2.03
92 INT176510 Binding of Spp1 21 0.42 22.1 2
93 INT83332 Regulation of Gene_expression of TFRC 5 0.22 3.03 1.99
94 INT83329 Regulation of Gene_expression of Tf 4 0.16 1.83 1.93
95 INT176516 Localization of Spp1 28 0.76 19.39 1.9
96 INT36499 Negative_regulation of Tf 6 0.38 3.02 1.85
97 INT130866 Positive_regulation of Gene_expression of TNFSF11 25 0.69 7.11 1.82
98 INT24283 Regulation of Positive_regulation of CA2 8 0.30 3.06 1.74
99 INT101875 Binding of MC4R 6 0.47 0.19 1.73
100 INT64807 Positive_regulation of Positive_regulation of CA2 10 0.41 1.21 1.7
101 INT113897 Positive_regulation of Transcription of Mc4r 1 0.45 0 1.7
102 INT35325 Regulation of Localization of CA2 10 0.32 1.13 1.69
103 INT133311 Binding of SPP1 10 0.37 9.47 1.65
104 INT182643 Binding of TNFSF11 15 0.35 13.12 1.61
105 INT146566 Transcription of Car2 8 0.56 1.51 1.6
106 INT178264 Positive_regulation of Gene_expression of Mc4r 10 0.43 3.52 1.57
107 INT88136 Positive_regulation of Gene_expression of Spp1 8 0.66 4.5 1.57
108 INT19798 Positive_regulation of Binding of Ca2 2 0.41 1.37 1.54
109 INT59795 Regulation of Tfrc 5 0.43 4.43 1.48
110 INT119936 Transcription of Ca2 13 0.59 1.71 1.47
111 INT88934 Regulation of SPP1 9 0.54 6.94 1.47
112 INT162057 Negative_regulation of TNFSF11 14 0.58 9.78 1.46
113 INT104250 Positive_regulation of Gene_expression of SPP1 17 0.69 13.22 1.44
114 INT15798 Positive_regulation of Gene_expression of TFRC 9 0.46 4.99 1.42
115 INT105551 Transcription of Tnfsf11 6 0.69 4.21 1.38
116 INT16239 Negative_regulation of Trf 9 0.32 4.06 1.35
117 INT88133 Positive_regulation of Spp1 8 0.66 10.07 1.33
118 INT36500 Negative_regulation of Gene_expression of Tf 4 0.38 1.22 1.29
119 INT135181 Regulation of Gene_expression of TNFSF11 5 0.61 6.98 1.27
120 INT60281 Negative_regulation of Negative_regulation of Car2 4 0.36 1.88 1.26
121 INT135186 Negative_regulation of Gene_expression of TNFSF11 10 0.58 2.69 1.25
122 INT6996 Positive_regulation of Tfrc 6 0.70 2.22 1.2
123 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
124 INT36443 Regulation of Trf 4 0.61 1.65 1.18
125 INT769 Regulation of Tf 3 0.30 1 1.18
126 INT105552 Positive_regulation of Transcription of Tnfsf11 3 0.31 2.94 1.17
127 INT48338 Gene_expression of Ahsg 2 0.52 0.25 1.16
128 INT199386 Negative_regulation of Phosphorylation of Car2 1 0.16 1.37 1.14
129 INT224429 Regulation of TNFSF11 8 0.61 4.35 1.13
130 INT49536 Regulation of Regulation of Ca2 6 0.38 3.89 1.13
131 INT23847 Phosphorylation of CA2 8 0.61 0.67 1.12
132 INT170511 Regulation of Localization of Car2 11 0.21 2.18 1.09
133 INT125147 Binding of Mc4r 10 0.41 3.55 1.08
134 INT238532 Negative_regulation of Binding of Car2 4 0.29 0.61 1.07
135 INT82540 Negative_regulation of TFRC 3 0.41 0.77 1.07
136 INT331098 Negative_regulation of Positive_regulation of Mc4r 1 0.32 1.08 1.07
137 INT70327 Regulation of Gene_expression of CA2 11 0.28 1.92 1.05
138 INT75846 Positive_regulation of MC4R 7 0.70 5.73 1.05
139 INT184547 Localization of Spp1 4 0.58 4.44 1.02
140 INT210586 Negative_regulation of Positive_regulation of Tnfsf11 3 0.41 1.4 1.02
141 INT184479 Regulation of Tfrc 3 0.09 3.97 1.01
142 INT132847 Negative_regulation of Localization of Tnfsf11 1 0.32 0.16 1.01
143 INT3568 Localization of Tf 4 0.62 1.27 1
144 INT70323 Negative_regulation of Gene_expression of CA2 13 0.41 6.55 0.97
145 INT47757 Transcription of CA2 5 0.67 1.16 0.97
146 INT275940 Negative_regulation of Syk 3 0.39 2.08 0.95
147 INT171963 Positive_regulation of Positive_regulation of Tnfsf11 3 0.42 2.44 0.93
148 INT113736 Negative_regulation of Positive_regulation of Mc4r 1 0.08 1.11 0.93
149 INT242988 Positive_regulation of Transcription of Spp1 4 0.28 3.28 0.92
150 INT33495 Regulation of Ahsg 1 0.23 0 0.86
151 INT48339 Regulation of Localization of Ahsg 1 0.21 0 0.86
152 INT48337 Localization of Ahsg 1 0.54 0 0.85
153 INT89368 Positive_regulation of Tf 7 0.34 3.62 0.83
154 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83
155 INT21727 Positive_regulation of Gene_expression of Tfrc 3 0.19 1.68 0.82
156 INT294998 Positive_regulation of Gene_expression of Tnfsf11 5 0.62 2.98 0.79
157 INT111289 Regulation of MC4R 4 0.43 1 0.78
158 INT146568 Positive_regulation of Transcription of Car2 1 0.31 1.39 0.78
159 INT176528 Regulation of Spp1 9 0.45 9.05 0.77
160 INT108044 Phosphorylation of Syk 3 0.25 1.39 0.77
161 INT85018 Positive_regulation of Positive_regulation of Mc4r 3 0.24 0.11 0.76
162 INT287841 Positive_regulation of Phosphorylation of Ca2 2 0.18 0.58 0.75
163 INT185838 Protein_catabolism of SPP1 1 0.65 1.68 0.74
164 INT197722 Regulation of TFRC 4 0.14 1.2 0.72
165 INT298598 Positive_regulation of Positive_regulation of TNFSF11 2 0.38 1.26 0.72
166 INT165760 Positive_regulation of Binding of Tnfsf11 2 0.36 1.83 0.71
167 INT185729 Negative_regulation of Gene_expression of Tnfsf11 3 0.52 2.07 0.69
168 INT176513 Transcription of Spp1 5 0.63 4.32 0.67
169 INT205171 Localization of TNFSF11 4 0.74 3.94 0.66
170 INT89363 Positive_regulation of Ahsg 2 0.11 1.11 0.63
171 INT136139 Transcription of Mc4r 4 0.70 1.83 0.62
172 INT88933 Regulation of Gene_expression of SPP1 7 0.45 6.05 0.59
173 INT264991 Positive_regulation of Localization of Tnfsf11 5 0.24 3.22 0.59
174 INT242987 Positive_regulation of Localization of Spp1 3 0.60 7.04 0.59
175 INT132324 Localization of SYK 2 0.78 1.9 0.59
176 INT278152 Negative_regulation of Syk 1 0.24 1.93 0.59
177 INT231014 Negative_regulation of MC4R 4 0.43 5.52 0.58
178 INT17964 Negative_regulation of Regulation of Car2 3 0.36 0.58 0.58
179 INT127975 Negative_regulation of SPP1 15 0.42 11.25 0.56
180 INT23095 Negative_regulation of Regulation of Ca2 2 0.36 0.34 0.56
181 INT132325 Positive_regulation of Localization of SYK 1 0.49 0.56 0.54
182 INT264594 Negative_regulation of Binding of CA2 4 0.20 1.1 0.52
183 INT133314 Positive_regulation of Binding of SPP1 2 0.22 2.38 0.52
184 INT248783 Positive_regulation of Protein_catabolism of CA2 1 0.13 0 0.52
185 INT210835 Phosphorylation of Mc4r 1 0.51 0.06 0.52
186 INT248784 Protein_catabolism of CA2 1 0.22 0 0.52
187 INT210837 Localization of Mc4r 5 0.73 0.87 0.51
188 INT154180 Negative_regulation of SYK 3 0.43 4.67 0.5
189 INT207379 Regulation of Negative_regulation of Tnfsf11 2 0.28 1.7 0.5
190 INT32137 Regulation of Negative_regulation of Ca2 7 0.36 2.17 0.49
191 INT324578 Positive_regulation of Regulation of Car2 1 0.20 0.23 0.49
192 INT302775 Negative_regulation of Gene_expression of Syk 1 0.27 0.84 0.48
193 INT340265 Localization of Tnfsf11 2 0.30 1.65 0.44
194 INT341289 Positive_regulation of Localization of Tnfsf11 1 0.13 1.26 0.44
195 INT154182 Phosphorylation of SYK 6 0.82 5.54 0.43
196 INT348865 Regulation of Transcription of CA2 1 0.21 0.69 0.43
197 INT137846 Regulation of Tnfsf11 5 0.48 1.62 0.42
198 INT47758 Positive_regulation of Transcription of CA2 3 0.49 0.54 0.42
199 INT249246 Positive_regulation of Phosphorylation of CA2 2 0.26 0.06 0.42
200 INT127976 Negative_regulation of Regulation of SPP1 1 0.37 1.62 0.41
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