GO:0045822

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Name negative regulation of heart contraction
Categary Process
Go Slim No
Go Link GO:0045822
Unique Molecular Interactions 448
Total Molecular Interactions 546
Total Single Events 6099
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of heart contraction. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of heart contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
2 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
3 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
4 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
5 INT62450 Il2 Positive_regulation of Localization of Crh 1 0.43 0.59 2.64
6 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
7 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
8 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
9 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
10 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
11 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
12 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
13 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
14 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
15 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
16 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
17 INT21536 Binding of Il2 and Il1 1 0.28 0 1.47
18 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
19 INT108727 Binding of ATP1A2 and CACNA1A 2 0.34 1.97 1.37
20 INT86172 Pdyn Positive_regulation of Gene_expression of Il2 1 0.20 0 1.33
21 INT62448 Il2 Positive_regulation of Crh 1 0.59 0.36 1.3
22 INT89943 Binding of Oprm1 and Il2 1 0.03 0.53 1.28
23 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25
24 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
25 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
26 INT329956 Binding of IL2 and IL23R 1 0.33 4.58 1.21
27 INT142154 Trpv1 Positive_regulation of Gene_expression of Il2 1 0.22 0 1.21
28 INT88193 Binding of IL2 and IL4 1 0.13 1.7 1.2
29 INT215648 Binding of Adora1 and Gabrd 1 0.03 0.06 1.16
30 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13
31 INT142572 D5Pas1 Negative_regulation of Nos1 2 0.02 0.14 1.11
32 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
33 INT317527 Binding of Hint1 and Nos1 1 0.27 0.1 1.11
34 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
35 INT88614 Penk Negative_regulation of Il2 1 0.23 0 1.08
36 INT54501 beta-End6-31 Positive_regulation of Gene_expression of Il2 1 0.03 0 1.06
37 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03
38 INT119914 Olr1714 Negative_regulation of Nos1 1 0.02 0.47 1.01
39 INT21415 POMC Positive_regulation of Gene_expression of IL2 1 0.00 0.27 1
40 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
41 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
42 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 0.00 0 0.96
43 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
44 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 0.43 0 0.94
45 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94
46 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94
47 INT258170 Binding of Adora1 and Ppap2a 1 0.05 0.26 0.94
48 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 0.43 0 0.94
49 INT215650 Binding of Adora1 and Drd1a 2 0.39 0.54 0.92
50 INT94501 Il2 Positive_regulation of Gene_expression of Ifng 1 0.03 1.63 0.92
51 INT317530 Negative_regulation of Binding of Nos1 and Oprm1 1 0.21 0.06 0.9
52 INT167771 Prkca Positive_regulation of Phosphorylation of Sigmar1 1 0.38 0.23 0.89
53 INT317515 Binding of Hint1 and Prkca 1 0.13 0.17 0.87
54 INT213977 Pax3 Negative_regulation of Gene_expression of Il2 1 0.00 0.25 0.86
55 INT213976 Calca Negative_regulation of Gene_expression of Il2 1 0.03 0.25 0.86
56 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
57 INT161306 POMC Negative_regulation of Transcription of IL2 1 0.24 0.27 0.85
58 INT215646 Binding of Adora1 and P2rx2 1 0.13 0.51 0.85
59 INT161307 JUN Positive_regulation of IL2 1 0.14 0.25 0.84
60 INT161305 NFKB1 Positive_regulation of IL2 1 0.25 0.25 0.83
61 INT317546 Oprm1 Regulation of Prkca 1 0.06 0.4 0.82
62 INT155761 Binding of Nos1 and Tjp1 1 0.13 1.01 0.82
63 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
64 INT190869 Binding of Prkca and Ltp 1 0.03 0.86 0.81
65 INT12883 Binding of IL2 and POMC 1 0.01 0 0.81
66 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
67 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
68 INT282063 Ngf Positive_regulation of Positive_regulation of Prkca 1 0.09 0.18 0.8
69 INT53199 Positive_regulation of Cd4 Positive_regulation of Gene_expression of Il2 1 0.52 0.72 0.8
70 INT8411 IL2 Regulation of Gene_expression of Vip 1 0.00 0.27 0.8
71 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8
72 INT60102 Adora1 Regulation of Localization of Calca 1 0.46 0 0.79
73 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78
74 INT157914 Trpv1 Regulation of Prkca 1 0.07 0.55 0.78
75 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
76 INT157917 TRPV1 Regulation of Prkca 1 0.04 0.55 0.78
77 INT110130 NR3C1 Regulation of ADORA1 1 0.04 0.73 0.77
78 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77
79 INT190867 Binding of Marcks and Prkca 1 0.17 0.8 0.77
80 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
81 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
82 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76
83 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
84 INT90125 Nfkb1 Regulation of Gene_expression of Nos1 1 0.17 0.39 0.76
85 INT90116 Nfkb1 Positive_regulation of Gene_expression of Nos1 1 0.32 0.39 0.76
86 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
87 INT185140 Elane Positive_regulation of Prkca 1 0.00 0 0.74
88 INT209035 Il2 Positive_regulation of Ccr1 1 0.00 0.38 0.73
89 INT21535 Binding of Il2 and Il1f5 1 0.13 0 0.73
90 INT209052 Il2 Positive_regulation of Il17a 1 0.03 0.38 0.73
91 INT209053 Il2 Positive_regulation of Elf1 1 0.06 0.38 0.73
92 INT209036 Il2 Positive_regulation of Cxcl1 1 0.04 0.38 0.73
93 INT209051 Il2 Positive_regulation of Csf2 1 0.02 0.38 0.73
94 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
95 INT266769 IL2 Positive_regulation of Localization of IL4 1 0.00 1.03 0.72
96 INT262573 Par2 Regulation of Positive_regulation of Prkca 1 0.05 0.57 0.72
97 INT266765 IL2 Positive_regulation of Localization of IL10 1 0.01 1.03 0.72
98 INT262581 Prkca Positive_regulation of Phosphorylation of Trpv1 1 0.13 0.28 0.71
99 INT27034 HERPUD1 Regulation of Gene_expression of IL2 1 0.38 0 0.71
100 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
101 INT151681 Il2 Negative_regulation of Art2a-ps 1 0.00 1.23 0.7
102 INT151678 Il2 Negative_regulation of Oas1b 1 0.13 1.23 0.7
103 INT106154 Calca Positive_regulation of Nos1 1 0.29 0.2 0.68
104 INT54502 Pomc Positive_regulation of Gene_expression of Il2 1 0.16 0 0.68
105 INT347962 Cpox Negative_regulation of Positive_regulation of Nos1 1 0.02 0.59 0.67
106 INT56308 POMC Negative_regulation of Gene_expression of Il2 1 0.01 0.1 0.67
107 INT82382 Penk Positive_regulation of Gene_expression of Il2 1 0.10 0 0.66
108 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
109 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66
110 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
111 INT118824 OPA1 Positive_regulation of Gene_expression of Nos1 2 0.03 0.24 0.65
112 INT78663 Dlst Regulation of Nos1 1 0.19 0.91 0.65
113 INT72504 IgG Negative_regulation of Il2 1 0.37 0 0.65
114 INT243639 Twist1 Negative_regulation of Gene_expression of Il2 1 0.24 1.28 0.65
115 INT86171 Oprl1 Positive_regulation of Gene_expression of Il2 1 0.30 0 0.64
116 INT215647 Adora1 Positive_regulation of Kcnj5 1 0.00 0 0.62
117 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6
118 INT13238 POMC Regulation of Gene_expression of IL2 1 0.09 0.26 0.59
119 INT60375 Il2 Regulation of Localization of Penk 1 0.03 0 0.59
120 INT74656 YY1 Positive_regulation of Localization of IL2 1 0.07 0.09 0.58
121 INT60374 Il2 Positive_regulation of Pomc 1 0.07 0 0.58
122 INT60372 Il2 Positive_regulation of Localization of Pomc 1 0.08 0 0.58
123 INT60373 Il2 Positive_regulation of Localization of Penk 1 0.52 0 0.58
124 INT39210 TF Positive_regulation of Gene_expression of IL2 1 0.17 0.07 0.57
125 INT142571 Pnoc Positive_regulation of Nos1 1 0.52 0.06 0.57
126 INT141362 EP300 Negative_regulation of Transcription of IL2 1 0.17 0 0.56
127 INT144598 Hrh2 Positive_regulation of IL2 1 0.01 0.08 0.56
128 INT296483 Prkca Positive_regulation of Localization of GRIP1 1 0.02 0.31 0.55
129 INT296462 Prkca Positive_regulation of Phosphorylation of Gria2 1 0.15 0.3 0.55
130 INT311256 Nt5e Positive_regulation of Positive_regulation of Adora1 1 0.49 0.19 0.54
131 INT182553 Ptger2 Regulation of Localization of Prkca 1 0.08 0.69 0.53
132 INT97425 Prkcg Regulation of Regulation of Nos1 1 0.06 0 0.53
133 INT137685 Phosphorylation of Prkca Negative_regulation of Binding of Srpx2 1 0.18 0 0.53
134 INT235876 Hspg2 Positive_regulation of Prkca 1 0.03 0.23 0.53
135 INT140356 Prkca Regulation of Phosphorylation of Prkce 1 0.18 0.44 0.52
136 INT184088 Epo Positive_regulation of Il2 1 0.07 0.26 0.52
137 INT151220 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Prkca 1 0.00 0.13 0.51
138 INT151219 Negative_regulation of SIGMAR1 Negative_regulation of Prkca 1 0.00 0.13 0.51
139 INT184132 Il2 Positive_regulation of Stat5a 1 0.09 0.26 0.51
140 INT317537 Oprm1 Positive_regulation of Phosphorylation of Nos1 1 0.16 0 0.5
141 INT235885 Prkca Negative_regulation of Slc6a4 1 0.05 0.14 0.49
142 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49
143 INT32597 Pomc Regulation of Gene_expression of Il2 1 0.29 0 0.49
144 INT90121 Nos1 Regulation of Fos 1 0.27 0.25 0.49
145 INT134048 Jak2 Regulation of Pik3cb 1 0.23 0.13 0.47
146 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47
147 INT134045 Jak2 Regulation of Stat3 1 0.26 0.13 0.47
148 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
149 INT134046 Jak2 Regulation of Gsk3b 1 0.22 0.13 0.47
150 INT257220 Binding of Nos1 and Flvcr2 1 0.00 0.17 0.47
151 INT296466 Prkca Regulation of Phosphorylation of Rbm39 1 0.00 0.27 0.47
152 INT134050 Positive_regulation of Jak2 Regulation of Stat3 1 0.44 0.13 0.47
153 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46
154 INT175788 Il2 Positive_regulation of Localization of Avp 1 0.03 0.41 0.46
155 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 0.12 1.07 0.46
156 INT244050 Binding of Gnb2l1 and Prkca 1 0.01 0 0.45
157 INT262575 Trpv1 Positive_regulation of Prkca 1 0.13 0.17 0.44
158 INT191896 Pbsn Positive_regulation of Prkca 1 0.04 0.85 0.44
159 INT165724 Bdkrb1 Positive_regulation of Adora1 1 0.24 1.65 0.43
160 INT159349 Zfp956 Negative_regulation of Nos1 1 0.03 0.61 0.43
161 INT196881 Ly6 Positive_regulation of Prkca 2 0.01 0.25 0.42
162 INT215651 Binding of Adora1 and Cpa1 1 0.00 0 0.42
163 INT111410 Nos1 Regulation of Vip 1 0.00 0 0.41
164 INT146273 Binding of Nos1 and Rasd1 1 0.34 0.18 0.41
165 INT319308 Socs4 Positive_regulation of Prkca 1 0.05 0.67 0.41
166 INT111409 Nos1 Regulation of Gene_expression of Vip 1 0.01 0 0.41
167 INT95206 Binding of CSF2 and IL2 1 0.40 1.81 0.4
168 INT238384 Tlr4 Positive_regulation of Prkca 1 0.06 0.81 0.4
169 INT237414 Binding of Jak2 and Bace1 1 0.20 0.77 0.39
170 INT292891 IL2 Regulation of IL5 1 0.02 0.25 0.39
171 INT235860 Prkca Regulation of Akap5 1 0.16 0 0.39
172 INT306693 Prkca Regulation of Positive_regulation of Nav1 1 0.10 0.06 0.39
173 INT146272 Binding of Nos1 and Nos1ap 1 0.28 0.2 0.39
174 INT292889 IL2 Regulation of IL12A 1 0.01 0.25 0.39
175 INT244046 Binding of Gabrg1 and Prkca 1 0.06 0 0.39
176 INT292886 IL2 Regulation of IL8 1 0.03 0.25 0.39
177 INT201274 Car2 Regulation of Gene_expression of Nos1 1 0.05 1.15 0.38
178 INT272751 EGFR Regulation of Negative_regulation of Prkca 1 0.01 0 0.38
179 INT272726 Mdk Regulation of Negative_regulation of Prkca 1 0.00 0 0.38
180 INT328828 Binding of Jak2 and Jak1 1 0.24 0 0.38
181 INT328827 Binding of Jak2 and Il6st 1 0.05 0 0.38
182 INT328820 Binding of Il6 and Jak2 1 0.09 0 0.38
183 INT172148 Binding of IL2 and TNF 2 0.05 0.67 0.37
184 INT172135 Binding of IL2 and IL6 1 0.01 0.57 0.37
185 INT27036 HERPUD1 Positive_regulation of Gene_expression of IL2 1 0.31 0 0.37
186 INT68119 Binding of IL2 and Oprd1 1 0.02 0 0.37
187 INT207643 Prkca Positive_regulation of Mapk1 1 0.09 0.17 0.37
188 INT320591 Ca2 Positive_regulation of Nos1 1 0.07 0.09 0.37
189 INT70924 Binding of Il2 and Il4 1 0.07 0.34 0.36
190 INT27032 ASNA1 Regulation of Gene_expression of IL2 1 0.03 0 0.36
191 INT211492 Positive_regulation of GRIN1 Positive_regulation of Prkca 1 0.01 0.87 0.36
192 INT320699 Gene_expression of Ptger2 Negative_regulation of Gene_expression of IL2 1 0.00 1.1 0.35
193 INT253944 Positive_regulation of Prkca Positive_regulation of Gene_expression of Ins1 1 0.01 1.53 0.35
194 INT235859 Binding of Prkca and Akap5 1 0.13 0 0.35
195 INT320694 C5 Regulation of Gene_expression of Il2 1 0.03 2.15 0.34
196 INT105768 Binding of Nos1 and Nqo1 1 0.00 0.26 0.34
197 INT267589 IL2 Positive_regulation of Gene_expression of IL12A 1 0.01 0.69 0.34
198 INT144448 Nqo1 Regulation of Nos1 1 0.11 0.09 0.34
199 INT144450 Regulation of Nqo1 Regulation of Nos1 1 0.11 0.1 0.34
200 INT39208 ALOX5 Regulation of Gene_expression of IL2 1 0.04 0.06 0.34

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of heart contraction. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of heart contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69
2 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
3 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
4 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
5 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
6 INT11807 Gene_expression of Il2 266 0.78 112 64.97
7 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
8 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
9 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
10 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
11 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21
12 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
13 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
14 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
15 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67
16 INT10763 Localization of IL2 157 0.80 81.11 33.21
17 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03
18 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7
19 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
20 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04
21 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96
22 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
23 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
24 INT11804 Positive_regulation of Gene_expression of Il2 70 0.70 33 21.63
25 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
26 INT117527 Binding of Prkca 25 0.48 6.43 21.05
27 INT15796 Regulation of IL2 66 0.61 25.43 20.62
28 INT11803 Positive_regulation of Il2 62 0.70 31.44 18.93
29 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96
30 INT10000 Regulation of Gene_expression of IL2 56 0.45 15.33 16.2
31 INT79458 Localization of Prkca 30 0.81 11.13 15.78
32 INT114025 Transcription of Nos1 20 0.70 16.48 15.63
33 INT25872 Positive_regulation of Adora1 19 0.69 4.9 15.01
34 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
35 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76
36 INT22098 Positive_regulation of Il2 27 0.69 14.77 14.1
37 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
38 INT20381 Localization of Il2 71 0.77 34.23 13.03
39 INT51014 Transcription of IL2 42 0.71 21.56 12.7
40 INT32595 Positive_regulation of Gene_expression of Il2 30 0.70 6.55 12.56
41 INT80251 Binding of Nos1 21 0.30 8.24 11.31
42 INT14334 Negative_regulation of Il2 31 0.58 18.63 11.08
43 INT19155 Binding of Adora1 25 0.47 6.41 10.72
44 INT90114 Regulation of Gene_expression of Nos1 18 0.62 6.38 10.52
45 INT110017 Phosphorylation of Nos1 12 0.60 1.64 10.3
46 INT12344 Negative_regulation of Gene_expression of Il2 28 0.59 15.53 10.23
47 INT112940 Negative_regulation of Positive_regulation of Prkca 12 0.45 5.85 10
48 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9
49 INT114406 Gene_expression of Adora1 28 0.72 6.83 9.13
50 INT22383 Binding of IL2 59 0.48 39.06 8.56
51 INT84672 Negative_regulation of Positive_regulation of Nos1 12 0.48 3.76 8.27
52 INT114023 Positive_regulation of Transcription of Nos1 7 0.60 5.35 8.06
53 INT71381 Localization of Nos1 33 0.79 11.46 8.05
54 INT32596 Regulation of Gene_expression of Il2 13 0.61 6.85 7.83
55 INT9350 Regulation of ADORA1 9 0.12 1.53 7.79
56 INT62452 Regulation of Il2 14 0.61 12.11 7.64
57 INT101699 Regulation of Adora1 14 0.61 3.7 7.59
58 INT70814 Negative_regulation of Il2 40 0.56 13.36 7.22
59 INT40159 Negative_regulation of Adora1 13 0.51 3.51 7.13
60 INT76197 Positive_regulation of ADORA1 7 0.59 5.06 7
61 INT9167 Binding of Adora1 6 0.40 0.53 6.9
62 INT76255 Gene_expression of ADORA1 11 0.78 2.51 6.85
63 INT92741 Positive_regulation of Positive_regulation of Nos1 8 0.47 1.44 6.58
64 INT25385 Positive_regulation of Localization of Il2 17 0.45 9.53 6.45
65 INT69499 Binding of Nos1 15 0.36 2.56 6.23
66 INT93658 Transcription of Nos1 16 0.72 6.85 6.16
67 INT64111 Negative_regulation of Gene_expression of Nos1 22 0.57 8.96 6.02
68 INT257199 Positive_regulation of Phosphorylation of Nos1 2 0.45 0.68 5.78
69 INT123045 Negative_regulation of Phosphorylation of Prkca 9 0.46 5.73 5.77
70 INT12066 Localization of Il2 16 0.75 3.06 5.7
71 INT84673 Localization of Nos1 19 0.80 5.01 5.62
72 INT11805 Regulation of Gene_expression of Il2 19 0.62 6.62 5.2
73 INT59320 Transcription of Il2 32 0.69 6.39 4.95
74 INT57441 Positive_regulation of Phosphorylation of Prkca 9 0.40 2.72 4.89
75 INT58459 Negative_regulation of Localization of IL2 13 0.41 6.46 4.88
76 INT83205 Negative_regulation of Negative_regulation of Prkca 6 0.43 1.14 4.87
77 INT113161 Gene_expression of Jak2 50 0.77 42.52 4.76
78 INT64160 Negative_regulation of Gene_expression of Prkca 8 0.43 3.01 4.72
79 INT79460 Positive_regulation of Localization of Prkca 11 0.70 2.72 4.71
80 INT88182 Gene_expression of Atp2a2 40 0.78 22.91 4.26
81 INT102654 Positive_regulation of Pln 10 0.48 3.53 4.19
82 INT153410 Negative_regulation of Jak2 5 0.59 10.71 3.98
83 INT76466 Regulation of Gene_expression of Prkca 6 0.45 0.94 3.91
84 INT29138 Positive_regulation of Localization of IL2 25 0.50 10.06 3.89
85 INT118154 Positive_regulation of Binding of Prkca 2 0.50 0.58 3.81
86 INT65527 Positive_regulation of Positive_regulation of Adora1 4 0.46 0.67 3.71
87 INT154225 Negative_regulation of Binding of Prkca 2 0.30 0.06 3.71
88 INT215604 Localization of Adora1 10 0.78 1.47 3.49
89 INT83206 Regulation of Regulation of Prkca 3 0.45 1.34 3.46
90 INT134875 Phosphorylation of Nos1 5 0.70 1.21 3.44
91 INT142568 Negative_regulation of Positive_regulation of Nos1 2 0.37 0.25 3.3
92 INT118153 Regulation of Positive_regulation of Prkca 5 0.45 3.15 3.23
93 INT190860 Regulation of Localization of Prkca 4 0.21 1.61 3.11
94 INT101477 Binding of ADORA1 8 0.31 0.42 3.07
95 INT108728 Regulation of ATP1A2 4 0.45 3.65 3.04
96 INT186507 Localization of ATP1A2 2 0.74 3.35 3.04
97 INT54178 Regulation of Adora1 5 0.39 0.29 2.85
98 INT11815 Regulation of Il2 16 0.59 4.81 2.83
99 INT215608 Negative_regulation of Binding of Adora1 5 0.41 1.35 2.73
100 INT49169 Regulation of Negative_regulation of Nos1 3 0.45 4.67 2.7
101 INT215601 Regulation of Positive_regulation of Adora1 9 0.60 1.74 2.66
102 INT22831 Negative_regulation of Positive_regulation of IL2 7 0.55 1.7 2.62
103 INT108608 Positive_regulation of Positive_regulation of Nos1 8 0.49 1.66 2.58
104 INT215599 Positive_regulation of Positive_regulation of Adora1 7 0.47 2.29 2.58
105 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57
106 INT114020 Gene_expression of Adora1 2 0.33 4.24 2.55
107 INT184583 Regulation of Phosphorylation of Prkca 3 0.21 1.76 2.5
108 INT141367 Negative_regulation of Transcription of IL2 9 0.32 2.07 2.43
109 INT114011 Negative_regulation of ATP1A2 5 0.45 6.12 2.41
110 INT184063 Positive_regulation of Jak2 17 0.69 10.97 2.37
111 INT25382 Binding of Il2 16 0.37 11.69 2.32
112 INT72531 Binding of Il2 2 0.48 0.18 2.32
113 INT144792 Negative_regulation of Transcription of Nos1 2 0.43 1.74 2.27
114 INT20289 Regulation of Localization of IL2 7 0.26 1.23 2.24
115 INT88183 Localization of Atp2a2 6 0.63 2.1 2.22
116 INT215611 Negative_regulation of Positive_regulation of Adora1 6 0.43 1.18 2.16
117 INT110016 Negative_regulation of Phosphorylation of Nos1 3 0.28 0.47 2.16
118 INT121884 Regulation of Binding of Nos1 2 0.33 1.63 2.15
119 INT107448 Positive_regulation of Jak2 8 0.50 5.33 1.98
120 INT99426 Negative_regulation of Gene_expression of Atp2a2 19 0.59 13.7 1.96
121 INT102866 Regulation of Negative_regulation of Prkca 2 0.43 1.27 1.95
122 INT52789 Regulation of Localization of Il2 9 0.30 1.9 1.88
123 INT170345 Negative_regulation of Localization of Prkca 5 0.23 0.88 1.88
124 INT32558 Negative_regulation of ADORA1 5 0.12 2.77 1.86
125 INT124556 Negative_regulation of Positive_regulation of Adora1 3 0.51 1.2 1.81
126 INT199591 Protein_catabolism of IL2 2 0.05 1.2 1.81
127 INT168519 Positive_regulation of Gene_expression of Adora1 4 0.61 0.75 1.75
128 INT97108 Phosphorylation of IL2 5 0.73 2.47 1.7
129 INT103959 Gene_expression of ATP1A2 3 0.67 2.47 1.68
130 INT64559 Positive_regulation of Negative_regulation of Nos1 2 0.41 1.58 1.68
131 INT97418 Regulation of Regulation of Nos1 2 0.41 0.94 1.68
132 INT157050 Regulation of Localization of Il2 1 0.06 0 1.67
133 INT29763 Negative_regulation of Adora1 3 0.42 0 1.64
134 INT267806 Negative_regulation of Pln 8 0.40 4.01 1.63
135 INT87236 Regulation of Negative_regulation of Il2 3 0.24 0.75 1.62
136 INT88746 Positive_regulation of Transcription of IL2 7 0.51 2.14 1.6
137 INT153409 Negative_regulation of Negative_regulation of Jak2 2 0.34 1.01 1.52
138 INT114013 Binding of ATP1A2 3 0.47 3.51 1.46
139 INT241721 Positive_regulation of Transcription of Adora1 3 0.50 1.39 1.41
140 INT152190 Positive_regulation of Phosphorylation of IL2 1 0.23 0.2 1.41
141 INT118581 Positive_regulation of ATP1A2 3 0.21 1.81 1.4
142 INT134041 Phosphorylation of Jak2 6 0.75 3.71 1.37
143 INT87029 Positive_regulation of Positive_regulation of IL2 8 0.50 8.17 1.36
144 INT241737 Transcription of Adora1 3 0.72 0.89 1.32
145 INT115938 Negative_regulation of Negative_regulation of Nos1 2 0.36 0.27 1.31
146 INT296914 Regulation of Pln 2 0.19 3.08 1.23
147 INT236091 Positive_regulation of Transcription of Il2 2 0.44 2.78 1.19
148 INT97261 Negative_regulation of Regulation of IL2 2 0.26 1.04 1.17
149 INT144393 Negative_regulation of Negative_regulation of Nos1 2 0.32 0.96 1.15
150 INT99427 Positive_regulation of Gene_expression of Atp2a2 5 0.64 4.13 1.14
151 INT76254 Positive_regulation of Positive_regulation of ADORA1 2 0.43 1.27 1.14
152 INT112004 Positive_regulation of Negative_regulation of IL2 3 0.50 1.56 1.08
153 INT22830 Negative_regulation of Binding of IL2 4 0.55 4.8 1.06
154 INT108609 Regulation of Localization of Nos1 3 0.45 0 1.06
155 INT205912 Negative_regulation of Gene_expression of Jak2 8 0.42 5.1 1.04
156 INT89847 Positive_regulation of Localization of Nos1 10 0.49 2.45 1.01
157 INT85869 Transcription of Il2 5 0.23 2.49 0.95
158 INT169336 Binding of Jak2 2 0.42 1.31 0.93
159 INT134879 Negative_regulation of Phosphorylation of Nos1 1 0.50 0.27 0.93
160 INT134040 Regulation of Jak2 3 0.41 1.07 0.92
161 INT106495 Positive_regulation of Localization of Atp2a2 1 0.37 0.19 0.91
162 INT184027 Phosphorylation of Jak2 6 0.82 2.58 0.87
163 INT70817 Negative_regulation of Transcription of Il2 5 0.40 0.25 0.87
164 INT215606 Positive_regulation of Localization of Adora1 3 0.49 0.44 0.87
165 INT317485 Regulation of Binding of Prkca 1 0.17 0.17 0.87
166 INT120447 Negative_regulation of Localization of Il2 9 0.56 1.74 0.86
167 INT134037 Positive_regulation of Phosphorylation of Jak2 1 0.46 0.25 0.86
168 INT92880 Localization of ADORA1 2 0.80 0.09 0.84
169 INT230516 Negative_regulation of Localization of Il2 5 0.15 2.64 0.79
170 INT19279 Negative_regulation of Negative_regulation of IL2 3 0.43 1.62 0.79
171 INT237408 Positive_regulation of Positive_regulation of Jak2 1 0.28 1.56 0.79
172 INT70815 Negative_regulation of Positive_regulation of Il2 4 0.40 1.37 0.76
173 INT73429 Negative_regulation of Atp2a2 20 0.20 9.05 0.74
174 INT91274 Negative_regulation of Positive_regulation of Il2 2 0.42 1.12 0.74
175 INT216258 Positive_regulation of Regulation of Nos1 2 0.40 1.45 0.74
176 INT113512 Regulation of Gene_expression of ADORA1 1 0.11 0.19 0.73
177 INT92547 Regulation of Localization of Nos1 2 0.43 0.61 0.7
178 INT97192 Regulation of Transcription of Nos1 1 0.55 1.94 0.68
179 INT94211 Positive_regulation of Negative_regulation of Prkca 1 0.43 0 0.67
180 INT54183 Regulation of Positive_regulation of Adora1 1 0.17 0 0.65
181 INT61623 Regulation of Positive_regulation of IL2 1 0.21 0.33 0.65
182 INT201270 Regulation of Positive_regulation of Nos1 2 0.38 2.27 0.63
183 INT215607 Positive_regulation of Negative_regulation of Adora1 1 0.45 0 0.63
184 INT110819 Negative_regulation of Pln 4 0.42 1.57 0.6
185 INT79459 Protein_catabolism of Prkca 2 1.00 0.09 0.6
186 INT144447 Regulation of Regulation of Nos1 1 0.43 0.1 0.59
187 INT112279 Regulation of Positive_regulation of Nos1 3 0.39 1.07 0.54
188 INT145099 Regulation of Transcription of Nos1 3 0.44 1.24 0.53
189 INT216748 Regulation of Localization of ADORA1 1 0.07 0.09 0.53
190 INT62456 Negative_regulation of Regulation of Il2 1 0.36 0.06 0.53
191 INT102051 Negative_regulation of Negative_regulation of Il2 1 0.58 0.08 0.52
192 INT267804 Gene_expression of Pln 4 0.47 1.45 0.51
193 INT279525 Negative_regulation of Transcription of Adora1 1 0.43 0.26 0.51
194 INT92549 Negative_regulation of Localization of Nos1 1 0.37 0.26 0.5
195 INT249309 Regulation of Gene_expression of Adora1 6 0.39 0.51 0.49
196 INT285338 Negative_regulation of Transcription of Il2 1 0.08 1.97 0.48
197 INT215600 Regulation of Binding of Adora1 1 0.08 0.09 0.48
198 INT184062 Binding of Jak2 5 0.37 3.13 0.47
199 INT166435 Negative_regulation of Atp2a2 8 0.43 0.4 0.44
200 INT110820 Positive_regulation of Negative_regulation of Pln 1 0.45 0 0.44
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