GO:0045839

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Name negative regulation of mitosis
Categary Process
Go Slim No
Go Link GO:0045839
Unique Molecular Interactions 132
Total Molecular Interactions 158
Total Single Events 1778
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of mitosis. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of mitosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
2 INT150890 Binding of Esr1 and Esr2 2 0.52 2.06 1.31
3 INT165941 Bmp7 Positive_regulation of Penk 1 0.28 0.43 0.95
4 INT165942 Bmp7 Positive_regulation of Transcription of Pomc 1 0.29 0.43 0.95
5 INT165940 Bmp7 Positive_regulation of Pomc 1 0.29 0.43 0.95
6 INT108812 Esr1 Positive_regulation of Positive_regulation of Oprm1 1 0.42 0.38 0.78
7 INT38057 Binding of Crp and Esr1 2 0.04 1.21 0.65
8 INT309158 Binding of Esr1 and Dlat 1 0.04 1.39 0.61
9 INT154014 Binding of Esr1 and Gabrg1 1 0.07 0.07 0.5
10 INT147179 Esr1 Regulation of Gene_expression of Penk 1 0.01 0.68 0.46
11 INT323840 Binding of Esr1 and Il1 1 0.04 0.9 0.42
12 INT117361 Binding of Esr1 and sea 1 0.02 1.38 0.38
13 INT117359 Binding of Esr1 and Wbc1 1 0.00 1.38 0.37
14 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32
15 INT309156 Esr1 Regulation of Gene_expression of Dlat 1 0.05 1.06 0.3
16 INT263587 Pdia3 Negative_regulation of Binding of Esr1 1 0.07 1.86 0.26
17 INT118461 Bmp7 Positive_regulation of Th 1 0.31 0.06 0.25
18 INT182346 Binding of Cd3e and Esr1 1 0.06 1.26 0.25
19 INT182349 Binding of Ms4a1 and Esr1 1 0.04 1.26 0.25
20 INT309160 Binding of Esr1 and Edc4 1 0.03 0.34 0.24
21 INT287894 VEGFA Positive_regulation of Localization of BMP4 1 0.04 2.49 0.2
22 INT308645 Binding of Esr1 and Itpr3 1 0.00 0 0.2
23 INT197618 Binding of Esr1 and Ppt1 1 0.01 0 0.18
24 INT173932 Binding of Esr1 and Il6 1 0.03 0.11 0.18
25 INT309154 Esr1 Positive_regulation of Gsdmc 1 0.01 0.44 0.15
26 INT309155 Negative_regulation of Esr1 Positive_regulation of Gsdmc 1 0.01 0.45 0.15
27 INT213551 Proc Regulation of Bmp7 1 0.00 0.15 0.14
28 INT88410 BMP7 Negative_regulation of CDK2 1 0.35 0 0.14
29 INT297312 Esr1 Positive_regulation of Scap 1 0.00 1.58 0.13
30 INT236588 Binding of Esr1 and Ins1 1 0.05 0.73 0.12
31 INT220114 Tnfrsf1a Positive_regulation of Esr1 1 0.14 1.14 0.1
32 INT237819 Binding of Esr1 and soc 1 0.04 0 0.1
33 INT125000 Binding of Esr1 and Tas2r108 1 0.04 0.33 0.1
34 INT287887 WNT1 Positive_regulation of Localization of BMP4 1 0.04 1.13 0.1
35 INT237812 Esr1 Positive_regulation of Positive_regulation of soc 1 0.05 0.6 0.1
36 INT201747 Itpr3 Positive_regulation of Localization of Esr1 2 0.03 1.19 0.09
37 INT308662 Binding of Esr1 and Fdft1 1 0.00 0.05 0.09
38 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
39 INT261396 Nsdhl Positive_regulation of Transcription of Esr1 1 0.02 2.1 0.09
40 INT232557 Erbb2 Positive_regulation of Esr1 1 0.23 0.26 0.09
41 INT129624 Bmp7 Positive_regulation of Gene_expression of Id2 1 0.26 0.31 0.08
42 INT129623 Bmp7 Positive_regulation of Gene_expression of Id3 1 0.37 0.31 0.08
43 INT129625 Id2 Positive_regulation of Gene_expression of Bmp7 1 0.24 0.31 0.08
44 INT192863 Binding of Ddit3 and Esr1 1 0.09 0.67 0.08
45 INT129622 Id3 Positive_regulation of Gene_expression of Bmp7 1 0.25 0.31 0.08
46 INT192860 Binding of Calr and Esr1 1 0.06 0.67 0.08
47 INT192865 Binding of Esr1 and Pdia3 1 0.07 0.67 0.08
48 INT192862 Binding of Esr1 and Hspa5 1 0.08 0.68 0.08
49 INT309159 Binding of Cav1 and Positive_regulation of Localization of Esr1 1 0.04 0 0.08
50 INT129627 Bmp7 Positive_regulation of Id2 1 0.24 0.25 0.07
51 INT303561 Binding of Fgf7 and Fgfr2 1 0.42 0.88 0.07
52 INT237811 Binding of Esr1 and Stim1 1 0.09 0 0.07
53 INT129626 Bmp7 Positive_regulation of Id3 1 0.25 0.25 0.07
54 INT237809 Esr1 Positive_regulation of Localization of Car2 1 0.09 0.66 0.07
55 INT303560 Binding of Fgfr2 and Fgf22 1 0.41 0.89 0.07
56 INT303562 Binding of Fgf10 and Fgfr2 1 0.40 0.88 0.07
57 INT201973 Bmp7 Positive_regulation of ap 1 0.00 0.18 0.06
58 INT142744 Esr1 Regulation of Transcription of Trpv6 1 0.42 0 0.06
59 INT118462 BMP7 Regulation of Bmp7 1 0.19 0 0.06
60 INT250865 Binding of Fgf8 and Fgfr3 1 0.18 0.3 0.05
61 INT242974 Mapk8 Negative_regulation of Positive_regulation of Esr1 1 0.01 1.39 0.05
62 INT236591 Binding of Esr1 and Positive_regulation of Tmed4 1 0.04 0.52 0.05
63 INT240726 Binding of Esr1 and Ca2 1 0.02 0.57 0.05
64 INT250855 Binding of Fgfr2 and Fgf8 1 0.12 0.3 0.05
65 INT210261 Bmp4 Regulation of Gene_expression of Tff3 1 0.64 0 0.05
66 INT225493 Binding of Esr1 and Pprc1 2 0.01 0.17 0.04
67 INT335702 Esr1 Regulation of Calr 1 0.03 0 0.04
68 INT236595 Binding of Esr1 and PELP1 1 0.27 0.17 0.04
69 INT335703 Esr1 Regulation of Localization of Calr 1 0.03 0 0.04
70 INT306560 BMP4 Positive_regulation of MAPK1 1 0.09 0.09 0.03
71 INT278579 Esr1 Positive_regulation of Negative_regulation of Tac2 1 0.47 0.25 0.03
72 INT287234 PDLIM7 Positive_regulation of Gene_expression of BMP7 1 0.14 0.12 0.03
73 INT303558 Binding of Fgfr2 and Dysf 1 0.01 0.44 0.03
74 INT331960 Positive_regulation of Binding of Esr1 and Tymp 1 0.00 0.15 0.03
75 INT331958 Binding of Esr1 and Tymp 1 0.00 0.15 0.03
76 INT316773 Esr1 Positive_regulation of Ddit3 1 0.02 0.41 0.03
77 INT221682 Binding of Esr1 and FRTS 1 0.01 0.15 0.03
78 INT215872 Atf4 Regulation of Esr1 1 0.30 0.42 0.03
79 INT306500 Clu Regulation of Esr1 1 0.22 0.13 0
80 INT332958 Binding of Esr1 and Ppara 1 0.36 0.21 0
81 INT225559 Binding of Esr1 and Ncoa6 1 0.18 0 0
82 INT342281 Binding of INS and Esr1 1 0.08 0.57 0
83 INT173771 Gh1 Regulation of Transcription of Esr1 1 0.00 0.13 0
84 INT189115 Binding of Esr1 and Tap1 1 0.07 0.05 0
85 INT197615 Esr1 Regulation of Gene_expression of Pgr 1 0.01 0.21 0
86 INT176289 Pcna Positive_regulation of Phosphorylation of Esr1 1 0.01 0.67 0
87 INT191062 Esr1 Regulation of Gene_expression of Bcl2 1 0.12 0.73 0
88 INT333446 ATM Positive_regulation of CHEK1 1 0.20 0 0
89 INT191096 Negative_regulation of Binding of Apc and Esr1 1 0.05 1.07 0
90 INT208018 Col4a4 Regulation of Gene_expression of Esr1 1 0.06 0.69 0
91 INT254435 Binding of Esr1 and Best1 1 0.21 0.06 0
92 INT333451 ATM Positive_regulation of Negative_regulation of CHEK1 1 0.14 0 0
93 INT225533 Binding of Emr1 and Esr1 1 0.01 0 0
94 INT225621 Positive_regulation of Binding of TARBP2 and Esr1 1 0.03 0 0
95 INT225531 R3hcc1 Positive_regulation of Positive_regulation of Esr1 1 0.00 0 0
96 INT197614 Esr1 Regulation of Pgr 1 0.01 0.07 0
97 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
98 INT225626 Binding of TARBP2 and Esr1 1 0.02 0 0
99 INT225611 Binding of Esr1 and Asc2 1 0.05 0 0
100 INT196038 Gene_expression of Bmp7 Positive_regulation of ALPP 1 0.03 0.1 0
101 INT225573 Rbm39 Positive_regulation of Positive_regulation of Esr1 1 0.08 0 0
102 INT196021 Bmp2 Positive_regulation of Gene_expression of Bmp4 1 0.09 0.08 0
103 INT202901 Binding of Esr1 and Lman1 1 0.01 0 0
104 INT191095 Positive_regulation of Binding of Apc and Esr1 1 0.06 1.08 0
105 INT296164 Mcph1 Regulation of Chek1 1 0.25 0.19 0
106 INT88409 BMP7 Positive_regulation of Gene_expression of ACTA1 1 0.09 0 0
107 INT202675 Fgf10 Positive_regulation of Fgfr2 1 0.45 0.07 0
108 INT232558 Binding of Erbb2 and Esr1 1 0.24 0.59 0
109 INT196022 Bmp7 Regulation of Bmp4 1 0.06 0.06 0
110 INT189104 Negative_regulation of Binding of Esr1 and Tap1 1 0.08 0.06 0
111 INT301366 Fgf18 Positive_regulation of Fgfr3 1 0.04 0.34 0
112 INT311395 Binding of Esr1 and 20S 1 0.04 0.11 0
113 INT240725 Esr1 Positive_regulation of Localization of Ca2 1 0.03 0.72 0
114 INT173770 Gh1 Regulation of Esr1 1 0.00 0.13 0
115 INT263586 Hspa5 Positive_regulation of Esr1 1 0.15 1.01 0
116 INT191098 Binding of Apc and Esr1 1 0.04 1.06 0
117 INT333459 TP53 Positive_regulation of CHEK1 1 0.09 0 0
118 INT306503 Tnf Negative_regulation of Gene_expression of Esr1 1 0.22 0.36 0
119 INT306499 Tnf Positive_regulation of Gene_expression of Esr1 1 0.24 0.36 0
120 INT156781 Binding of Esr1 and Fshr 1 0.02 0 0
121 INT225605 Binding of Ncoa6 and Positive_regulation of Esr1 1 0.25 0 0
122 INT225529 Binding of Esr1 and Rbm39 1 0.07 0 0
123 INT176287 Cdk2 Positive_regulation of Phosphorylation of Esr1 1 0.05 0.67 0
124 INT225588 Binding of Asc2 and Positive_regulation of Esr1 1 0.07 0 0
125 INT156780 Esr1 Positive_regulation of Binding of Fshr 1 0.02 0 0
126 INT307156 Esr1 Positive_regulation of Hspa5 1 0.04 0.79 0
127 INT225534 Rbm39 Positive_regulation of Esr1 1 0.09 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of mitosis. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of mitosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
2 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
3 INT37296 Binding of Esr1 117 0.43 62.51 27.33
4 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52
5 INT17237 Regulation of Esr1 74 0.43 49.09 17.25
6 INT2038 Localization of Esr1 104 0.79 40.12 13.27
7 INT22901 Negative_regulation of Gene_expression of Esr1 30 0.42 20.92 6.29
8 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51
9 INT117205 Transcription of Esr1 23 0.65 9.4 4.14
10 INT141148 Gene_expression of BMP7 24 0.71 14.34 3.44
11 INT100295 Gene_expression of Bmp7 27 0.78 14.34 3.3
12 INT120088 Gene_expression of Bmp4 37 0.73 13.89 1.73
13 INT222089 Positive_regulation of Localization of Esr1 19 0.49 8.73 1.58
14 INT165538 Binding of Bmp7 5 0.37 1.87 1.39
15 INT287241 Positive_regulation of BMP7 10 0.43 2.68 1.38
16 INT128752 Negative_regulation of Localization of Esr1 11 0.43 4.8 1.23
17 INT81945 Negative_regulation of Binding of Esr1 3 0.32 0.55 1.06
18 INT173747 Regulation of Positive_regulation of Esr1 4 0.37 4.85 0.95
19 INT236576 Positive_regulation of Binding of Esr1 3 0.41 2.39 0.92
20 INT154465 Negative_regulation of Transcription of Esr1 1 0.05 0 0.92
21 INT128755 Protein_catabolism of Esr1 10 0.57 4.61 0.9
22 INT142122 Regulation of Gene_expression of Bmp4 5 0.43 2.69 0.86
23 INT33818 Positive_regulation of Negative_regulation of Esr1 3 0.40 0.98 0.82
24 INT210247 Positive_regulation of Bmp4 6 0.65 4.36 0.8
25 INT141150 Localization of BMP7 4 0.56 2.84 0.76
26 INT118469 Gene_expression of Fgfr3 5 0.72 6.98 0.75
27 INT161778 Regulation of Gene_expression of Esr1 13 0.51 9.46 0.73
28 INT239494 Regulation of Localization of Esr1 4 0.19 1.15 0.72
29 INT96422 Gene_expression of Bmp4 18 0.69 3.26 0.63
30 INT9836 Negative_regulation of Negative_regulation of Esr1 3 0.29 0.95 0.63
31 INT100294 Positive_regulation of Gene_expression of Bmp7 8 0.46 5.41 0.61
32 INT89126 Regulation of BMP7 7 0.45 2.5 0.58
33 INT173748 Phosphorylation of Esr1 11 0.77 5.7 0.55
34 INT173744 Positive_regulation of Positive_regulation of Esr1 10 0.43 7.05 0.52
35 INT165537 Negative_regulation of Bmp7 2 0.43 0.55 0.52
36 INT159214 Positive_regulation of Gene_expression of BMP7 6 0.46 2.16 0.51
37 INT146778 Negative_regulation of Fgfr2 1 0.32 0.66 0.48
38 INT129620 Regulation of Gene_expression of Bmp7 3 0.42 3.2 0.47
39 INT240710 Positive_regulation of Regulation of Esr1 1 0.09 1.34 0.47
40 INT142124 Binding of Bmp4 1 0.35 0.46 0.45
41 INT202626 Negative_regulation of Fgfr2 2 0.41 2.48 0.42
42 INT180688 Transcription of Bmp4 3 0.58 0.35 0.41
43 INT180702 Positive_regulation of Transcription of Bmp4 3 0.42 0.35 0.41
44 INT118460 Binding of Bmp7 3 0.46 1.3 0.4
45 INT236580 Regulation of Binding of Esr1 4 0.39 1.1 0.34
46 INT196032 Positive_regulation of Gene_expression of Bmp7 10 0.17 1.31 0.31
47 INT192845 Negative_regulation of Positive_regulation of Esr1 2 0.35 1.15 0.31
48 INT196024 Gene_expression of Bmp7 20 0.26 1.88 0.3
49 INT96569 Negative_regulation of CHEK1 4 0.32 3.08 0.29
50 INT159213 Gene_expression of BMP4 8 0.74 2.1 0.28
51 INT159212 Positive_regulation of Gene_expression of BMP4 2 0.66 0.91 0.28
52 INT185009 Negative_regulation of BMP4 2 0.56 1.04 0.25
53 INT176080 Gene_expression of Fgfr2 4 0.68 2.34 0.24
54 INT223739 Binding of Fgfr2 3 0.30 0.94 0.22
55 INT142121 Positive_regulation of Gene_expression of Bmp4 3 0.47 7 0.21
56 INT120085 Negative_regulation of Gene_expression of Bmp4 5 0.55 0.61 0.17
57 INT339267 Negative_regulation of BMP7 1 0.43 0.55 0.17
58 INT291955 Positive_regulation of Protein_catabolism of Esr1 1 0.06 0.14 0.17
59 INT269777 Regulation of Regulation of Esr1 2 0.02 1.17 0.16
60 INT94167 Regulation of CHEK1 1 0.04 1.7 0.16
61 INT118459 Regulation of Bmp7 3 0.43 0.25 0.15
62 INT183400 Positive_regulation of Transcription of Esr1 4 0.30 1.06 0.14
63 INT201968 Positive_regulation of Bmp7 2 0.43 1.11 0.14
64 INT232556 Positive_regulation of Phosphorylation of Esr1 1 0.20 0.41 0.12
65 INT287912 Localization of BMP4 1 0.18 1.13 0.1
66 INT196033 Negative_regulation of Gene_expression of Bmp4 3 0.21 0.45 0.09
67 INT250839 Binding of Fgfr3 1 0.16 0.19 0.08
68 INT355332 Localization of Bmp7 1 0.09 1.92 0.08
69 INT316570 Binding of BMP7 3 0.37 0.95 0.07
70 INT287244 Transcription of BMP7 1 0.66 0.15 0.07
71 INT210243 Negative_regulation of Bmp4 1 0.55 0.55 0.07
72 INT287242 Positive_regulation of Transcription of BMP7 1 0.64 0.15 0.07
73 INT139365 Negative_regulation of Negative_regulation of CHEK1 1 0.23 1.67 0.06
74 INT303546 Binding of Fgfr2 1 0.46 0.74 0.06
75 INT153022 Negative_regulation of Bmp7 1 0.01 0.27 0.06
76 INT196030 Positive_regulation of Bmp4 6 0.62 2.55 0.04
77 INT210238 Positive_regulation of Negative_regulation of Bmp4 1 0.47 0 0.04
78 INT253182 Positive_regulation of Positive_regulation of Bmp4 1 0.45 0.58 0.04
79 INT201965 Transcription of Bmp7 2 0.49 0.93 0.03
80 INT303525 Localization of Fgfr2 1 0.72 0.28 0.03
81 INT221677 Negative_regulation of Protein_catabolism of Esr1 1 0.08 0.15 0.03
82 INT303547 Positive_regulation of Negative_regulation of Fgfr2 1 0.48 1.07 0.03
83 INT196034 Positive_regulation of Gene_expression of Bmp4 4 0.45 0.63 0
84 INT260779 Negative_regulation of Bmp4 4 0.23 0.94 0
85 INT196027 Binding of Bmp4 2 0.13 0.97 0
86 INT142119 Regulation of Bmp4 2 0.58 0.29 0
87 INT212461 Gene_expression of Chek1 2 0.65 0.11 0
88 INT276327 Positive_regulation of Gene_expression of Fgfr3 2 0.43 1.83 0
89 INT151839 Positive_regulation of Bmp7 2 0.27 0.24 0
90 INT296150 Negative_regulation of Gene_expression of Chek1 1 0.35 0.11 0
91 INT243057 Positive_regulation of Fgfr3 1 0.46 0.79 0
92 INT202623 Negative_regulation of Gene_expression of Fgfr2 1 0.32 0 0
93 INT319036 Gene_expression of Fgfr2 1 0.48 0.08 0
94 INT252942 Phosphorylation of Chek1 1 0.14 0.63 0
95 INT260766 Negative_regulation of Gene_expression of Bmp7 1 0.35 0 0
96 INT303553 Regulation of Gene_expression of Fgfr3 1 0.25 0.3 0
97 INT335681 Regulation of Negative_regulation of Esr1 1 0.03 0 0
98 INT309486 Positive_regulation of Chek1 1 0.22 0.6 0
99 INT243058 Positive_regulation of Positive_regulation of Fgfr3 1 0.46 0.8 0
100 INT339667 Localization of Bmp4 1 0.38 0.27 0
101 INT173746 Regulation of Transcription of Esr1 1 0.04 0 0
102 INT201963 Positive_regulation of Binding of Bmp7 1 0.05 0 0
103 INT314125 Regulation of Transcription of Bmp7 1 0.25 0.88 0
104 INT329779 Positive_regulation of CHEK1 1 0.22 0.76 0
105 INT314127 Regulation of Bmp7 1 0.25 0.88 0
106 INT296140 Negative_regulation of Chek1 1 0.35 0.45 0
107 INT301359 Positive_regulation of Fgfr3 1 0.19 0.64 0
108 INT329783 Phosphorylation of CHEK1 1 0.26 0.82 0
109 INT351554 Negative_regulation of Gene_expression of BMP4 1 0.26 0 0
110 INT301357 Negative_regulation of Positive_regulation of Fgfr3 1 0.16 0.35 0
111 INT196028 Transcription of Bmp7 1 0.18 0 0
112 INT303524 Positive_regulation of Fgfr2 1 0.66 0.22 0
113 INT196029 Localization of Bmp7 1 0.27 0.09 0
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