GO:0045861

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Name negative regulation of proteolysis
Categary Process
Go Slim No
Go Link GO:0045861
Unique Molecular Interactions 637
Total Molecular Interactions 904
Total Single Events 9246
Pain Genes Associated 24

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of proteolysis. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
2 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
3 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
4 INT24689 Binding of PLAT and Serpine1 1 0.00 3.77 1.64
5 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
6 INT105112 Plat Positive_regulation of JUN 1 0.01 1.55 1.58
7 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
8 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
9 INT18659 Plat Regulation of ZC3H12D 1 0.02 0.1 1.29
10 INT343949 SERPINE2 Positive_regulation of Positive_regulation of Slco1c1 1 0.00 0.59 1.27
11 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
12 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
13 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09
14 INT343950 SERPINE2 Positive_regulation of Slco1c1 1 0.00 1.63 1.07
15 INT105113 Plat Positive_regulation of NFKB1 1 0.03 1.06 1.06
16 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
17 INT195668 Binding of F2 and THBD 7 0.08 5.67 0.98
18 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
19 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
20 INT107001 F2 Positive_regulation of PAR1 4 0.05 2.15 0.92
21 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
22 INT138602 Negative_regulation of BCL2L2 Positive_regulation of F2 1 0.00 0.67 0.92
23 INT138601 BCL2L2 Positive_regulation of F2 1 0.00 0.66 0.91
24 INT56500 Ide Regulation of Maoa 1 0.21 0 0.89
25 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
26 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8
27 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
28 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
29 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
30 INT125523 PLAT Positive_regulation of GDF15 1 0.13 1.33 0.75
31 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
32 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
33 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
34 INT106999 F2 Positive_regulation of PAR4 3 0.06 1.83 0.72
35 INT106992 F2 Positive_regulation of PARD3 3 0.05 1.83 0.72
36 INT317573 Binding of Oprm1 and Pik3r1 1 0.12 0.33 0.71
37 INT124257 Plat Positive_regulation of Jun 5 0.12 3.33 0.67
38 INT150338 Binding of F2 and F2R 1 0.11 0.4 0.67
39 INT329589 Serpina5 Positive_regulation of PTX3 1 0.03 1.52 0.66
40 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
41 INT224693 Timp2 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
42 INT207111 F2 Positive_regulation of Pawr 2 0.07 1.38 0.64
43 INT309664 Binding of Pik3r1 and Cia1 1 0.02 1.32 0.64
44 INT116752 Ngf Regulation of Pik3r1 1 0.56 0.29 0.63
45 INT302469 F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.82 0.62
46 INT101718 PLAT Positive_regulation of Transcription of OPRM1 1 0.22 0.06 0.61
47 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
48 INT101719 PLAT Positive_regulation of NFYC 1 0.13 0.1 0.6
49 INT29847 INS Regulation of Localization of AVP 1 0.23 0.24 0.59
50 INT101717 PLAT Positive_regulation of JUND 1 0.17 0.1 0.59
51 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
52 INT37034 PLAT Positive_regulation of PLDN 1 0.08 0.15 0.58
53 INT37035 PLAT Negative_regulation of ODC1 1 0.45 0.15 0.58
54 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
55 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
56 INT342619 Mmp2 Negative_regulation of Timp2 1 0.42 1.48 0.57
57 INT342621 VEGFA Negative_regulation of Timp2 1 0.09 1.53 0.57
58 INT145718 Positive_regulation of Plat Positive_regulation of Bdnf 1 0.20 0 0.56
59 INT96089 Binding of F2 and Pf4 1 0.00 1.31 0.56
60 INT96098 Binding of PPBP and F2 1 0.00 1.31 0.56
61 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
62 INT105111 Negative_regulation of Plat Positive_regulation of NFKB1 1 0.03 0.53 0.54
63 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
64 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
65 INT311767 INS Negative_regulation of Gene_expression of SLC1A3 1 0.52 0 0.52
66 INT317565 Oprm1 Positive_regulation of Pik3r1 1 0.14 0.05 0.52
67 INT213809 F2 Positive_regulation of F2rl3 2 0.12 0.61 0.5
68 INT63512 Vip Positive_regulation of Localization of SERPINE2 1 0.63 1.84 0.5
69 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
70 INT84515 IRF6 Positive_regulation of Gene_expression of F2 1 0.02 0.15 0.49
71 INT84520 Gene_expression of F2 Positive_regulation of F13A1 1 0.03 0.16 0.49
72 INT180958 Binding of F13A1 and PLAT 2 0.03 2.16 0.47
73 INT101001 GHRH Regulation of Localization of INS 1 0.28 0 0.47
74 INT341622 Binding of F2 and CTRC 1 0.06 1.22 0.46
75 INT173295 F2 Positive_regulation of OR1S1 1 0.01 0.15 0.46
76 INT22674 Binding of SERPINE1 and PLAT 7 0.04 0.65 0.45
77 INT125520 PLAT Positive_regulation of Gene_expression of GDF15 1 0.13 0.74 0.42
78 INT162043 F2 Positive_regulation of Gene_expression of OSM 1 0.44 1.13 0.41
79 INT132730 Plat Positive_regulation of Il6 1 0.08 0.76 0.41
80 INT132729 Plat Positive_regulation of Il1b 1 0.09 0.76 0.41
81 INT124260 Plat Positive_regulation of Mapk1 1 0.14 0.81 0.41
82 INT162041 F2 Positive_regulation of Positive_regulation of FOS 1 0.13 1.14 0.41
83 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
84 INT69109 Acot1 Regulation of Gene_expression of Serpine2 1 0.04 0 0.4
85 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
86 INT338044 F2 Positive_regulation of Pard3 1 0.08 0.38 0.4
87 INT29052 Binding of INS and INSRR 1 0.02 0.23 0.4
88 INT29053 Regulation of Binding of INS and INSRR 1 0.01 0.24 0.4
89 INT78621 PRL Positive_regulation of Localization of INS 2 0.06 0.5 0.39
90 INT291256 INS Negative_regulation of Positive_regulation of Mdk 1 0.01 1.65 0.39
91 INT166157 Ccr9 Positive_regulation of Pik3r1 1 0.55 2.14 0.39
92 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
93 INT198652 F2 Positive_regulation of Gene_expression of CD36 1 0.03 1.32 0.37
94 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
95 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
96 INT302466 Positive_regulation of F2 Positive_regulation of Gene_expression of MMP9 1 0.01 1.1 0.35
97 INT183786 IL6 Negative_regulation of INS 1 0.09 1.61 0.35
98 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34
99 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34
100 INT183793 INS Negative_regulation of Binding of Ros1 1 0.16 1.66 0.34
101 INT183785 INS Positive_regulation of Gene_expression of NFKBIB 1 0.03 1.83 0.34
102 INT224701 Timp3 Negative_regulation of TNF 1 0.01 0.65 0.34
103 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34
104 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
105 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34
106 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
107 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
108 INT214854 SERPINE1 Positive_regulation of PLAT 1 0.24 0.42 0.33
109 INT168779 Binding of Pik3r1 and Tnf 1 0.01 0.73 0.33
110 INT253147 Positive_regulation of Nr1h2 Negative_regulation of Positive_regulation of Ptpn1 1 0.17 0.61 0.33
111 INT318299 Binding of F2 and PRTN3 1 0.01 1.92 0.33
112 INT253142 Positive_regulation of Nr1h2 Negative_regulation of Gene_expression of Mmp9 1 0.05 0.6 0.33
113 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
114 INT312803 F2 Positive_regulation of NPEPPS 1 0.01 1.32 0.32
115 INT93896 Plat Positive_regulation of Gtf3a 1 0.00 0.51 0.32
116 INT312802 F2 Positive_regulation of Binding of NPEPPS 1 0.01 1.33 0.32
117 INT338051 Ngf Positive_regulation of Localization of F2 1 0.11 0 0.32
118 INT123397 F2 Positive_regulation of Gene_expression of PTAFR 1 0.05 0.51 0.32
119 INT238895 Binding of CRP and INS 1 0.00 0.93 0.32
120 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
121 INT124259 Negative_regulation of Plat Positive_regulation of Jun 4 0.11 1.74 0.31
122 INT15685 Binding of PLAT and Serpine1 3 0.36 1.01 0.31
123 INT142286 Binding of PLG and Plat 2 0.52 0.7 0.31
124 INT28688 Binding of Kng1 and Ctsl1 1 0.15 0 0.31
125 INT162042 F2 Regulation of OSM 1 0.17 1.17 0.31
126 INT195669 Binding of F2 and PROC 1 0.04 1.44 0.31
127 INT246690 exf Regulation of Localization of Ide 1 0.00 0.17 0.3
128 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3
129 INT162045 F2 Positive_regulation of Phosphorylation of MAPK3 1 0.30 0.99 0.3
130 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
131 INT239344 Nr1h2 Positive_regulation of Gene_expression of Srebf1 1 0.26 0.84 0.29
132 INT96100 Binding of SELP and F2 1 0.01 0.67 0.29
133 INT247083 Binding of F5 and PLAT 1 0.03 0.88 0.29
134 INT239324 Nr1h2 Positive_regulation of Hltf 1 0.04 0.78 0.29
135 INT96094 Binding of Selp and F2 1 0.00 0.67 0.29
136 INT239347 Nr1h2 Positive_regulation of Srebf1 1 0.26 0.78 0.29
137 INT185141 Pik3r1 Positive_regulation of Snrpd1 1 0.00 0.16 0.29
138 INT96099 Binding of TAT and F2 1 0.01 0.68 0.29
139 INT239329 Nr1h2 Positive_regulation of Gene_expression of Hltf 1 0.04 0.84 0.29
140 INT96093 Binding of Serpinc1 and F2 1 0.00 0.68 0.29
141 INT239336 Nr1h2 Positive_regulation of Gene_expression of Fas 1 0.07 0.84 0.29
142 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
143 INT162039 F2 Regulation of Gene_expression of OSM 1 0.29 0.94 0.29
144 INT71550 GTPBP4 Regulation of Localization of INS 1 0.00 0.16 0.28
145 INT291201 Regulation of INS Positive_regulation of GOPC 1 0.00 0.35 0.28
146 INT162044 F2 Positive_regulation of Localization of FOS 1 0.32 0.9 0.28
147 INT162040 F2 Positive_regulation of Localization of JUN 1 0.20 0.9 0.28
148 INT291200 INS Positive_regulation of GOPC 1 0.01 0.3 0.28
149 INT252806 F2 Positive_regulation of Gene_expression of CCL2 1 0.01 0.8 0.27
150 INT44759 Negative_regulation of PLAT Positive_regulation of ODC1 1 0.27 0 0.27
151 INT246689 Zglp1 Positive_regulation of Ide 1 0.06 0.28 0.27
152 INT312894 Binding of Gsk3b and Positive_regulation of Gene_expression of Hdac6 1 0.08 1.3 0.27
153 INT246693 Zglp1 Positive_regulation of Localization of Ide 1 0.08 0.34 0.27
154 INT220870 Timp3 Negative_regulation of Adamts4 1 0.03 0.15 0.27
155 INT242878 INS Negative_regulation of Gene_expression of SPI1 1 0.04 1.81 0.27
156 INT220871 Timp3 Negative_regulation of Adamts1 1 0.01 0.15 0.27
157 INT224406 INS Regulation of Localization of PYY 1 0.11 0.27 0.27
158 INT224405 INS Regulation of Localization of CCK 1 0.12 0.27 0.27
159 INT338039 F2 Positive_regulation of Positive_regulation of Prkca 1 0.04 0.52 0.27
160 INT44760 PLAT Positive_regulation of ODC1 1 0.29 0 0.27
161 INT125522 PLAT Regulation of Gene_expression of GDF15 1 0.08 0.46 0.26
162 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
163 INT125513 PLAT Positive_regulation of Transcription of GDF15 1 0.12 0.44 0.26
164 INT74433 Binding of INS and Cpe 2 0.03 0 0.25
165 INT308120 Binding of F2 and F10 2 0.07 1.25 0.25
166 INT348755 Plat Regulation of Gene_expression of Cldn5 1 0.10 0.45 0.25
167 INT139357 Nr1h2 Regulation of Gene_expression of Ptges 1 0.07 0.5 0.25
168 INT125517 Negative_regulation of PLAT Positive_regulation of GDF15 1 0.12 0.46 0.25
169 INT291261 INS Positive_regulation of Phosphorylation of Mdk 1 0.01 0.28 0.25
170 INT309888 INS Positive_regulation of Gene_expression of FAAH 1 0.04 1.19 0.25
171 INT125519 Regulation of PLAT Positive_regulation of NFKB1 1 0.07 0.44 0.24
172 INT242875 INS Negative_regulation of Gene_expression of TLR4 1 0.11 1.41 0.24
173 INT341538 F2 Positive_regulation of F2RL1 1 0.02 0.68 0.24
174 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23
175 INT87750 IGFBP3 Negative_regulation of INS 1 0.11 0.86 0.23
176 INT273055 Plat Positive_regulation of Gene_expression of Nos2 1 0.01 1.34 0.23
177 INT63196 INS Positive_regulation of IL2 1 0.10 0.3 0.23
178 INT63203 INS Positive_regulation of ESR1 1 0.09 0.3 0.23
179 INT63195 INS Positive_regulation of CD8A 1 0.19 0.3 0.23
180 INT63420 F2 Positive_regulation of Gene_expression of ITGA2B 1 0.14 0.45 0.23
181 INT37033 PLAT Negative_regulation of PLDN 1 0.08 0.07 0.23
182 INT63199 INS Positive_regulation of PGR 1 0.11 0.3 0.23
183 INT328382 Positive_regulation of Ghrl Positive_regulation of Localization of INS 1 0.03 1.08 0.23
184 INT108808 Binding of IAPP and INS 1 0.32 1.36 0.23
185 INT63421 F2 Positive_regulation of Gene_expression of SELP 1 0.09 0.45 0.23
186 INT250782 APC Negative_regulation of F2 1 0.00 0.86 0.23
187 INT173292 F2 Positive_regulation of EGF 1 0.00 0.07 0.23
188 INT207845 Binding of INS and Hypism 3 0.04 2.88 0.22
189 INT255044 GLP1R Positive_regulation of Localization of INS 3 0.49 1.47 0.22
190 INT246686 Ide Regulation of Ros1 1 0.03 0.41 0.22
191 INT214481 ROS1 Negative_regulation of Gene_expression of INS 1 0.00 0.37 0.22
192 INT39263 POMC Negative_regulation of INS 1 0.23 0.6 0.22
193 INT63510 SERPINE2 Positive_regulation of Localization of Vip 1 0.15 0.52 0.21
194 INT257397 Binding of FGD1 and INS 1 0.07 0.27 0.21
195 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 0.04 0.5 0.21
196 INT124262 Negative_regulation of Plat Positive_regulation of Mapk1 1 0.13 0.41 0.21
197 INT355103 Binding of Ins2 and Ins1 1 0.12 2 0.21
198 INT124263 Plat Positive_regulation of Gene_expression of Cpox 1 0.07 0.42 0.21
199 INT74437 Negative_regulation of Cpe Positive_regulation of Localization of INS 1 0.06 0 0.2
200 INT115006 Binding of Serpine1 and Cpb2 1 0.09 1.53 0.2

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of proteolysis. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT812 Localization of INS 1026 0.81 515.6 145.31
2 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
3 INT251 Regulation of INS 398 0.62 232.47 55.04
4 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
5 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
6 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
7 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
8 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
9 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
10 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
11 INT82929 Gene_expression of Plat 58 0.78 26.96 13.85
12 INT24684 Localization of PLAT 30 0.78 26.21 13.56
13 INT15921 Positive_regulation of Serpine1 85 0.68 81.24 13.4
14 INT14572 Binding of INS 205 0.48 175.43 13.38
15 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
16 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
17 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63
18 INT1190 Positive_regulation of F2 53 0.70 46.41 11.64
19 INT56494 Localization of Ide 73 0.68 22.9 11.26
20 INT4498 Gene_expression of F2 83 0.65 57.4 10.8
21 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
22 INT15449 Positive_regulation of Plat 32 0.69 12.76 9.71
23 INT65390 Positive_regulation of Plat 30 0.70 23.31 9.31
24 INT2271 Gene_expression of F2 51 0.76 30.21 7.97
25 INT1925 Gene_expression of PLAT 47 0.75 34.76 7.88
26 INT15918 Gene_expression of Serpine1 60 0.62 41.73 7.72
27 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
28 INT17501 Negative_regulation of F2 70 0.58 32.23 7.51
29 INT10513 Gene_expression of Plat 44 0.76 19.49 7.17
30 INT717 Regulation of F2 29 0.61 17.46 6.99
31 INT1038 Negative_regulation of F2 26 0.58 15.12 6.75
32 INT124488 Positive_regulation of Gene_expression of Plat 14 0.70 5.46 6.52
33 INT1926 Positive_regulation of PLAT 54 0.66 31.42 6.49
34 INT17262 Negative_regulation of Plat 17 0.59 15.14 6.36
35 INT124825 Transcription of Plat 8 0.70 3.15 5.68
36 INT22839 Gene_expression of F2 31 0.74 15.53 5.56
37 INT63507 Gene_expression of SERPINE2 8 0.70 8.35 5.56
38 INT157802 Negative_regulation of Timp2 7 0.54 5.75 5.51
39 INT107247 Regulation of Plat 10 0.44 7.21 5.14
40 INT20650 Positive_regulation of F2 26 0.69 15.49 5.08
41 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01
42 INT56495 Positive_regulation of Localization of Ide 20 0.53 3.53 4.92
43 INT51839 Positive_regulation of Localization of PLAT 5 0.49 7.09 4.92
44 INT15920 Regulation of Serpine1 34 0.42 17.36 4.89
45 INT104668 Negative_regulation of Plat 27 0.49 17.18 4.83
46 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63
47 INT72703 Gene_expression of Ide 79 0.70 45.04 4.47
48 INT9842 Binding of F2 36 0.47 22.79 4.42
49 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34
50 INT55743 Gene_expression of Timp2 25 0.31 8.95 4.3
51 INT17548 Negative_regulation of Serpine1 30 0.57 24.69 3.93
52 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
53 INT176208 Gene_expression of Nr1h2 27 0.59 22.75 3.84
54 INT56493 Regulation of Localization of Ide 15 0.47 3.53 3.82
55 INT27466 Negative_regulation of Kng1 7 0.10 7.79 3.56
56 INT228465 Positive_regulation of Timp2 4 0.64 6.29 3.54
57 INT28802 Binding of F2 15 0.47 8.8 3.47
58 INT43085 Negative_regulation of Ide 28 0.39 19.96 3.45
59 INT63506 Localization of F2 21 0.77 7.53 3.41
60 INT165911 Localization of Pik3r1 15 0.51 7.94 3.2
61 INT1924 Regulation of PLAT 11 0.60 6.3 3.16
62 INT179338 Gene_expression of Timp2 7 0.55 5.75 3.13
63 INT10517 Localization of Plat 16 0.47 8.44 3.11
64 INT10136 Negative_regulation of PLAT 23 0.42 11.18 3.02
65 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
66 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
67 INT69099 Gene_expression of Serpine2 22 0.78 7.89 2.87
68 INT124489 Regulation of Gene_expression of Plat 5 0.45 0.48 2.87
69 INT10101 Binding of PLAT 24 0.36 12.62 2.78
70 INT10512 Positive_regulation of Gene_expression of Plat 8 0.46 1.4 2.69
71 INT14447 Localization of F2 20 0.79 12.77 2.67
72 INT9374 Regulation of Plat 19 0.61 6.04 2.55
73 INT71933 Positive_regulation of Gene_expression of F2 19 0.56 14.24 2.53
74 INT191974 Regulation of Ide 16 0.38 9.54 2.52
75 INT124826 Positive_regulation of Transcription of Plat 3 0.68 0.33 2.38
76 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32
77 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27
78 INT10514 Negative_regulation of Gene_expression of Plat 8 0.47 6.22 2.24
79 INT120109 Negative_regulation of Timp2 8 0.33 3.28 2.23
80 INT63505 Negative_regulation of F2 18 0.57 7.4 2.2
81 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18
82 INT15922 Positive_regulation of Positive_regulation of Serpine1 6 0.31 8.34 2.16
83 INT114421 Positive_regulation of Positive_regulation of Pik3r1 9 0.49 4.07 2.13
84 INT8237 Positive_regulation of Kng1 16 0.69 4.41 2.12
85 INT169352 Negative_regulation of Timp3 10 0.58 6.94 1.92
86 INT176173 Positive_regulation of Nr1h2 19 0.52 10.95 1.88
87 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86
88 INT215928 Binding of Timp2 1 0.23 0.79 1.66
89 INT25445 Binding of Plat 7 0.41 12.75 1.63
90 INT88667 Negative_regulation of Gene_expression of F2 11 0.41 5.53 1.62
91 INT124824 Negative_regulation of Transcription of Plat 1 0.43 0.48 1.54
92 INT22836 Regulation of F2 9 0.59 2.3 1.49
93 INT12035 Regulation of F2 21 0.45 12.66 1.47
94 INT56497 Negative_regulation of Localization of Ide 12 0.44 5.34 1.42
95 INT39444 Negative_regulation of Positive_regulation of F2 7 0.59 5.82 1.42
96 INT191970 Positive_regulation of Ide 29 0.51 12.94 1.4
97 INT153515 Localization of Plat 10 0.77 4.21 1.4
98 INT109301 Positive_regulation of Phosphorylation of Pik3r1 5 0.42 1.45 1.38
99 INT24685 Localization of Serpine1 12 0.59 7.76 1.32
100 INT39634 Regulation of Gene_expression of F2 4 0.22 1.72 1.31
101 INT39443 Positive_regulation of Positive_regulation of F2 6 0.70 4.31 1.3
102 INT53252 Gene_expression of Kng1 7 0.67 2.18 1.27
103 INT139356 Regulation of Nr1h2 2 0.43 2.95 1.27
104 INT2270 Positive_regulation of Gene_expression of F2 6 0.21 4.23 1.26
105 INT138343 Positive_regulation of Localization of F2 5 0.41 5.06 1.24
106 INT109104 Positive_regulation of Protein_catabolism of INS 4 0.50 4.44 1.24
107 INT153514 Positive_regulation of Localization of Plat 2 0.62 0.55 1.23
108 INT123839 Positive_regulation of Timp2 6 0.15 4.69 1.21
109 INT20100 Binding of Serpine1 16 0.29 6.78 1.18
110 INT116206 Transcription of Plat 3 0.67 1.52 1.18
111 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15
112 INT15919 Positive_regulation of Gene_expression of Serpine1 6 0.41 4.5 1.15
113 INT199315 Binding of Plat 8 0.34 7.02 1.14
114 INT183046 Transcription of INS 25 0.70 11.14 1.13
115 INT63508 Negative_regulation of SERPINE2 6 0.55 3.01 1.11
116 INT233286 Positive_regulation of Timp3 1 0.02 1.46 1.1
117 INT220465 Binding of BAG6 7 0.30 6.41 1.07
118 INT174273 Positive_regulation of Binding of F2 3 0.08 2.99 1.02
119 INT116207 Positive_regulation of Transcription of Plat 1 0.49 0.66 1.02
120 INT58470 Negative_regulation of Binding of INS 14 0.43 7.2 1.01
121 INT305307 Gene_expression of Serpina5 88 0.78 10.09 1
122 INT20156 Positive_regulation of Negative_regulation of Serpine1 4 0.49 2.89 0.97
123 INT77054 Regulation of Gene_expression of Timp2 2 0.05 0.7 0.96
124 INT171636 Negative_regulation of Gene_expression of PLAT 6 0.35 2.92 0.93
125 INT27467 Localization of Kng1 2 0.76 0.78 0.87
126 INT196322 Binding of F2 18 0.15 7.74 0.83
127 INT167833 Positive_regulation of Ins2 4 0.50 6.52 0.82
128 INT55742 Positive_regulation of Gene_expression of Timp2 2 0.08 1.81 0.82
129 INT288191 Positive_regulation of Localization of Pik3r1 4 0.15 1.27 0.81
130 INT342616 Regulation of Timp2 1 0.56 1.75 0.81
131 INT59786 Binding of SERPINE2 4 0.32 2.98 0.79
132 INT354257 Regulation of Localization of PLAT 1 0.18 0.91 0.79
133 INT37118 Regulation of Kng1 3 0.49 1.09 0.77
134 INT12057 Regulation of Negative_regulation of INS 7 0.40 3.92 0.76
135 INT138606 Negative_regulation of Positive_regulation of F2 2 0.12 0.54 0.74
136 INT134754 Positive_regulation of Gene_expression of PLAT 9 0.49 4.75 0.72
137 INT286615 Phosphorylation of Ide 7 0.31 5.22 0.7
138 INT176180 Negative_regulation of Nr1h2 6 0.16 7.47 0.69
139 INT324890 Negative_regulation of Negative_regulation of Timp2 2 0.40 1.09 0.68
140 INT176184 Positive_regulation of Gene_expression of Nr1h3 2 0.49 0 0.68
141 INT176218 Gene_expression of Nr1h3 2 0.65 0 0.67
142 INT112649 Negative_regulation of Serpine2 10 0.43 1.41 0.66
143 INT229282 Binding of Nr1h2 7 0.17 5.11 0.66
144 INT312830 Regulation of Ins2 2 0.39 1.45 0.66
145 INT191978 Positive_regulation of Gene_expression of Ide 16 0.63 6.8 0.65
146 INT183789 Positive_regulation of Phosphorylation of INS 5 0.50 4.87 0.64
147 INT166456 Negative_regulation of Gene_expression of Pik3r1 4 0.41 1.72 0.64
148 INT168000 Protein_catabolism of F2 6 0.63 2.19 0.63
149 INT312882 Negative_regulation of Hdac6 1 0.52 1.86 0.63
150 INT14570 Regulation of Positive_regulation of INS 8 0.45 4.97 0.62
151 INT184185 Transcription of Kng1 1 0.05 1.66 0.62
152 INT63509 Localization of SERPINE2 1 0.75 2.37 0.62
153 INT135666 Negative_regulation of Negative_regulation of Pik3r1 2 0.29 0.3 0.6
154 INT69100 Regulation of Gene_expression of Serpine2 1 0.18 0 0.59
155 INT69098 Positive_regulation of Gene_expression of F2 5 0.66 3.79 0.58
156 INT53251 Positive_regulation of Gene_expression of Kng1 2 0.60 0.71 0.58
157 INT98932 Positive_regulation of Negative_regulation of F2 1 0.04 1.06 0.58
158 INT342612 Positive_regulation of Positive_regulation of Timp2 1 0.43 1.05 0.57
159 INT127878 Negative_regulation of Positive_regulation of Timp2 1 0.07 1.12 0.57
160 INT79839 Positive_regulation of Serpina5 3 0.44 1.2 0.56
161 INT210522 Protein_catabolism of Ide 16 0.79 7.73 0.55
162 INT124487 Negative_regulation of Gene_expression of Plat 4 0.43 1.88 0.55
163 INT14571 Regulation of Binding of INS 2 0.23 2.44 0.53
164 INT210539 Binding of Ide 11 0.29 6.09 0.52
165 INT20099 Regulation of Positive_regulation of Serpine1 2 0.40 1.75 0.52
166 INT183918 Negative_regulation of Gene_expression of Kng1 1 0.04 1.16 0.51
167 INT139666 Binding of Timp2 3 0.13 0.55 0.5
168 INT320172 Negative_regulation of Binding of F2 2 0.41 1.92 0.5
169 INT191968 Negative_regulation of Gene_expression of Ide 9 0.39 7.14 0.47
170 INT195092 Protein_catabolism of F2 4 0.26 2.75 0.47
171 INT58015 Regulation of Gene_expression of Serpine1 3 0.41 2.61 0.47
172 INT112651 Positive_regulation of Gene_expression of Serpine2 3 0.70 3.36 0.47
173 INT35435 Negative_regulation of Positive_regulation of Serpine1 5 0.42 2.26 0.46
174 INT312821 Binding of Ins2 2 0.37 2.13 0.46
175 INT11363 Regulation of Gene_expression of PLAT 1 0.27 0.87 0.46
176 INT213286 Positive_regulation of Binding of INS 6 0.50 4.85 0.45
177 INT67179 Negative_regulation of Binding of F2 3 0.41 2.23 0.45
178 INT53667 Gene_expression of Ins2 10 0.65 5.65 0.44
179 INT213272 Negative_regulation of Phosphorylation of INS 7 0.40 9.13 0.44
180 INT17835 Regulation of Localization of Plat 3 0.29 0.53 0.44
181 INT12343 Protein_catabolism of PLAT 2 0.76 0.73 0.44
182 INT343948 Positive_regulation of SERPINE2 1 0.07 0.76 0.44
183 INT258821 Negative_regulation of Localization of PLAT 4 0.57 3.32 0.43
184 INT139667 Transcription of Timp2 2 0.17 0.45 0.43
185 INT34939 Positive_regulation of Negative_regulation of Plat 2 0.45 1 0.43
186 INT184444 Binding of Timp3 3 0.47 0.25 0.41
187 INT10102 Regulation of Binding of PLAT 2 0.42 1.24 0.41
188 INT312829 Positive_regulation of Positive_regulation of Ins2 1 0.50 1.73 0.4
189 INT162049 Phosphorylation of F2 3 0.47 0.99 0.39
190 INT69104 Positive_regulation of Localization of F2 2 0.66 0.06 0.39
191 INT14569 Positive_regulation of Negative_regulation of INS 4 0.36 3.52 0.37
192 INT69103 Negative_regulation of Localization of F2 2 0.56 0.48 0.37
193 INT25010 Positive_regulation of Localization of Plat 2 0.31 0.81 0.37
194 INT190598 Localization of Nr1h2 3 0.25 1.6 0.36
195 INT187606 Negative_regulation of Gene_expression of Serpine1 3 0.05 1.78 0.36
196 INT161436 Transcription of F2 2 0.69 1.21 0.36
197 INT184187 Negative_regulation of Binding of Kng1 1 0.03 1.07 0.36
198 INT269822 Transcription of Timp2 1 0.36 1.43 0.36
199 INT184186 Binding of Kng1 1 0.03 1.06 0.36
200 INT168766 Positive_regulation of Binding of Pik3r1 3 0.21 1.54 0.35
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