GO:0045862

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Name positive regulation of proteolysis
Categary Process
Go Slim No
Go Link GO:0045862
Unique Molecular Interactions 59
Total Molecular Interactions 82
Total Single Events 358
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of proteolysis. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT72229 Binding of NFKBIL1 and BTRC 1 0.00 0 0.73
2 INT141362 EP300 Negative_regulation of Transcription of IL2 1 0.17 0 0.56
3 INT167651 Binding of Oprd1 and Ep300 1 0.02 0.09 0.55
4 INT167652 Binding of Ep300 and Ngf 1 0.09 0.06 0.51
5 INT167655 Binding of Polr2f and Ep300 1 0.01 0.06 0.51
6 INT72230 Binding of BTRC and EMID1 1 0.00 0 0.49
7 INT72227 Binding of BTRC and AP1M2 1 0.00 0 0.49
8 INT195552 Binding of Rela and Ep300 1 0.03 0.2 0.45
9 INT195554 Binding of Nfkb1 and Ep300 1 0.08 0.2 0.45
10 INT335028 Fgf15 Positive_regulation of Fgfr4 1 0.40 0.31 0.25
11 INT256656 Binding of EP300 and HHIP 1 0.22 0 0.24
12 INT72231 Negative_regulation of Binding of NFKBIL1 and BTRC 1 0.00 0 0.24
13 INT256706 Binding of Hsp90b1 and Wfs1 1 0.43 5.02 0.2
14 INT325529 Binding of Stat3 and Ep300 1 0.01 0.22 0.19
15 INT325531 Positive_regulation of Binding of Stat3 and Ep300 1 0.02 0.22 0.19
16 INT119267 Binding of EP300 and PPM1E 1 0.01 0.46 0.17
17 INT200304 Hdac2 Negative_regulation of Rorb 1 0.00 0 0.12
18 INT200346 Hdac2 Negative_regulation of Lhcgr 1 0.04 0 0.12
19 INT319731 Ep300 Positive_regulation of Binding of Rela 1 0.01 0.37 0.12
20 INT200347 Hdac2 Negative_regulation of Transcription of Lhcgr 1 0.04 0 0.12
21 INT319727 Binding of Crebbp and Ep300 1 0.02 0.36 0.11
22 INT250866 Binding of Fgfr4 and Fgf8 1 0.12 0.35 0.11
23 INT319728 Positive_regulation of Binding of Crebbp and Ep300 1 0.03 0.36 0.11
24 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11
25 INT287880 Binding of CREB1 and EP300 1 0.01 0 0.08
26 INT331790 Binding of gr and Hdac2 1 0.01 0.74 0.07
27 INT331791 Akt1 Negative_regulation of Hdac2 1 0.03 0.8 0.07
28 INT331798 Regulation of Binding of gr and Hdac2 1 0.02 0.75 0.07
29 INT119266 CDKN1A Regulation of EP300 1 0.47 0.44 0.07
30 INT268678 Binding of HDAC2 and NCOR2 1 0.18 2.67 0.07
31 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
32 INT225569 Binding of Ncoa6 and Ep300 1 0.18 0.63 0.04
33 INT256707 Eif2ak3 Regulation of Gene_expression of Wfs1 1 0.10 0.78 0.03
34 INT225562 Binding of Srcs4 and Ep300 1 0.02 0 0
35 INT256703 Negative_regulation of Hsp90b1 Positive_regulation of Wfs1 1 0.42 0.24 0
36 INT352148 Ift88 Negative_regulation of Bcl2l2 1 0.00 0.19 0
37 INT158907 Ogt Negative_regulation of Gene_expression of Ada 1 0.44 0 0
38 INT256700 Negative_regulation of Binding of Hsp90b1 and Wfs1 1 0.52 0 0
39 INT287875 EP300 Negative_regulation of HDAC9 1 0.04 0.51 0
40 INT271996 Binding of Plk1 and Tsc1 1 0.09 0.32 0
41 INT172604 Binding of EP300 and TP53 1 0.00 0 0
42 INT243107 Binding of Src and Ep300 1 0.06 0.17 0
43 INT172606 EP300 Positive_regulation of CREBBP 1 0.00 0.07 0
44 INT225619 Binding of TARBP2 and Ep300 1 0.02 0 0
45 INT256705 Binding of Wfs1 and Xbp1 1 0.19 0.39 0
46 INT271997 Binding of Cdk1 and Plk1 1 0.03 0.3 0
47 INT172605 Positive_regulation of Binding of EP300 and TP53 1 0.00 0 0
48 INT256704 Xbp1 Positive_regulation of Positive_regulation of Wfs1 1 0.26 0.4 0
49 INT352150 Ift88 Negative_regulation of Bcl2 1 0.00 0.19 0
50 INT256702 Binding of Wfs1 and Tmed4 1 0.01 0.61 0
51 INT243111 Binding of Crebbp and Ep300 1 0.16 0.17 0
52 INT225543 Binding of D0Nrs1 and Ep300 1 0.01 0 0
53 INT225563 Binding of Tpr and Ep300 1 0.00 0 0
54 INT249822 Foxm1 Positive_regulation of Transcription of Plk1 1 0.50 0.12 0
55 INT352149 Ift88 Negative_regulation of Bcl2l1 1 0.00 0.19 0
56 INT272197 Binding of CAPN3 and DYSF 1 0.42 0.38 0
57 INT158906 Ogt Negative_regulation of Ada 1 0.33 0 0
58 INT225622 Binding of STL and Ep300 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of proteolysis. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of proteolysis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03
2 INT2213 Regulation of EP300 10 0.54 4.72 4.5
3 INT41878 Positive_regulation of EP300 13 0.61 5.24 3.95
4 INT54749 Binding of BTRC 7 0.09 0.88 2.9
5 INT171511 Gene_expression of EP300 14 0.53 4.17 2.29
6 INT26123 Regulation of Ep300 6 0.23 1.22 2.03
7 INT171514 Binding of EP300 13 0.32 4.32 2.01
8 INT26124 Negative_regulation of Ep300 5 0.37 1.25 1.94
9 INT172622 Localization of EP300 8 0.65 2.56 1.72
10 INT54750 Gene_expression of BTRC 4 0.14 0.99 1.55
11 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48
12 INT70821 Positive_regulation of Ep300 4 0.25 1.47 1.2
13 INT272879 Negative_regulation of Hdac2 8 0.37 5.96 1.17
14 INT68339 Gene_expression of HDAC2 3 0.51 1.71 1.1
15 INT167650 Binding of Ep300 1 0.09 0.14 1
16 INT317791 Localization of HDAC2 2 0.50 2.31 0.99
17 INT200250 Binding of Hdac2 6 0.22 2.97 0.76
18 INT74097 Gene_expression of Ep300 6 0.52 1.89 0.73
19 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7
20 INT272206 Gene_expression of CAPN3 4 0.77 3.83 0.7
21 INT272886 Negative_regulation of Gene_expression of Hdac2 4 0.23 4.63 0.69
22 INT272868 Positive_regulation of Hdac2 3 0.27 2.15 0.5
23 INT303541 Gene_expression of Fgfr4 2 0.62 0.72 0.43
24 INT256681 Regulation of Wfs1 8 0.43 4.72 0.36
25 INT333916 Negative_regulation of HDAC2 2 0.18 1.38 0.36
26 INT342958 Positive_regulation of Gene_expression of CAPN3 1 0.69 0.66 0.35
27 INT187587 Binding of Ep300 11 0.35 2.37 0.34
28 INT272882 Positive_regulation of Binding of Hdac2 2 0.20 1.12 0.32
29 INT177856 Negative_regulation of Gene_expression of HDAC2 1 0.19 0.12 0.3
30 INT321344 Positive_regulation of Fgfr4 1 0.09 0.23 0.27
31 INT256682 Gene_expression of Wfs1 1 0.74 6.63 0.25
32 INT334990 Regulation of Positive_regulation of Fgfr4 1 0.36 0.25 0.25
33 INT334992 Positive_regulation of Fgfr4 1 0.40 0.24 0.25
34 INT72235 Negative_regulation of BTRC 3 0.02 0 0.24
35 INT325492 Regulation of Ep300 1 0.04 0.29 0.24
36 INT272202 Negative_regulation of CAPN3 4 0.59 0.99 0.2
37 INT212787 Negative_regulation of Binding of EP300 1 0.13 0.53 0.2
38 INT256666 Regulation of Gene_expression of EP300 1 0.14 0.07 0.2
39 INT256661 Regulation of Positive_regulation of EP300 1 0.23 0.07 0.2
40 INT325490 Positive_regulation of Ep300 1 0.03 0.22 0.19
41 INT250849 Binding of Fgfr4 1 0.11 0.54 0.19
42 INT342960 Regulation of CAPN3 1 0.45 0.39 0.18
43 INT256696 Positive_regulation of Wfs1 1 0.66 9.14 0.17
44 INT256684 Positive_regulation of Gene_expression of Wfs1 1 0.66 3.62 0.16
45 INT342959 Protein_catabolism of CAPN3 1 0.87 0.41 0.16
46 INT266991 Regulation of Hdac2 2 0.07 0.74 0.15
47 INT298653 Positive_regulation of Binding of EP300 1 0.11 0.8 0.15
48 INT256675 Regulation of Gene_expression of Wfs1 1 0.43 2.33 0.09
49 INT256687 Positive_regulation of Transcription of Wfs1 1 0.44 1.95 0.09
50 INT256693 Transcription of Wfs1 1 0.68 2.44 0.08
51 INT331786 Negative_regulation of Binding of Hdac2 1 0.11 1.2 0.08
52 INT284980 Positive_regulation of Protein_catabolism of HDAC2 1 0.20 0.81 0.08
53 INT284976 Protein_catabolism of HDAC2 1 0.28 0.8 0.08
54 INT342956 Positive_regulation of Negative_regulation of CAPN3 1 0.46 0.16 0.06
55 INT331784 Negative_regulation of Positive_regulation of Hdac2 1 0.11 0.52 0.05
56 INT352129 Negative_regulation of Ift88 1 0.00 0.72 0.05
57 INT292252 Phosphorylation of EP300 1 0.20 0.55 0.05
58 INT331778 Regulation of Phosphorylation of Hdac2 1 0.11 0.49 0.03
59 INT331787 Phosphorylation of Hdac2 1 0.20 0.49 0.03
60 INT237226 Gene_expression of Plk1 3 0.59 0.78 0
61 INT235154 Transcription of Ep300 2 0.24 1.38 0
62 INT249774 Positive_regulation of Plk1 2 0.41 0.25 0
63 INT222914 Negative_regulation of Gene_expression of EP300 1 0.02 0.05 0
64 INT256676 Regulation of Binding of Wfs1 1 0.43 0.35 0
65 INT272203 Binding of CAPN3 1 0.37 0.23 0
66 INT337478 Binding of HDAC2 1 0.14 0.07 0
67 INT256692 Negative_regulation of Wfs1 1 0.41 0 0
68 INT271928 Binding of Plk1 1 0.07 0.29 0
69 INT256671 Regulation of Positive_regulation of Wfs1 1 0.59 1.77 0
70 INT342957 Positive_regulation of CAPN3 1 0.43 0.18 0
71 INT286555 Binding of Ift88 1 0.30 0.08 0
72 INT332370 Regulation of Plk1 1 0.21 0.13 0
73 INT256686 Binding of Wfs1 1 0.46 0.91 0
74 INT332346 Phosphorylation of Plk1 1 0.62 0 0
75 INT342954 Positive_regulation of Positive_regulation of CAPN3 1 0.43 0.1 0
76 INT249761 Transcription of Plk1 1 0.60 0.12 0
77 INT256677 Regulation of Transcription of Wfs1 1 0.59 0.5 0
78 INT342961 Negative_regulation of Gene_expression of CAPN3 1 0.43 0.1 0
79 INT286544 Localization of Ift88 1 0.52 1.26 0
80 INT249770 Positive_regulation of Gene_expression of Plk1 1 0.44 0.12 0
81 INT332343 Positive_regulation of Phosphorylation of Plk1 1 0.38 0 0
82 INT271923 Regulation of Binding of Plk1 1 0.09 0.29 0
83 INT237227 Negative_regulation of Gene_expression of Plk1 1 0.08 0.54 0
84 INT158905 Negative_regulation of Ogt 1 0.36 0 0
85 INT256672 Positive_regulation of Positive_regulation of Wfs1 1 0.44 0.24 0
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