GO:0045879

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Name negative regulation of smoothened signaling pathway
Categary Process
Go Slim No
Go Link GO:0045879
Unique Molecular Interactions 197
Total Molecular Interactions 311
Total Single Events 1670
Pain Genes Associated 16

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of smoothened signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of smoothened signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT269444 Binding of RAB5A and HHIP 1 0.04 0 5.79
2 INT269443 Positive_regulation of Binding of RAB5A and HHIP 1 0.04 0 1.06
3 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
4 INT237204 Binding of LGALS4 and Cd3e 1 0.15 2.61 0.8
5 INT269454 Positive_regulation of Binding of GOPC and HHIP 1 0.01 0 0.73
6 INT72229 Binding of NFKBIL1 and BTRC 1 0.00 0 0.73
7 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
8 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
9 INT224823 CTBS Regulation of SALL1 1 0.14 0.53 0.66
10 INT139079 Tnip1 Negative_regulation of Ptch1 1 0.20 0.63 0.62
11 INT54942 Rb1 Regulation of Gab1 1 0.02 0.39 0.59
12 INT73073 Binding of Cd3e and Oprk1 1 0.28 0.06 0.59
13 INT182348 Binding of Cd3e and Crp 1 0.15 2.33 0.56
14 INT269442 Binding of GOPC and HHIP 1 0.01 0 0.52
15 INT72230 Binding of BTRC and EMID1 1 0.00 0 0.49
16 INT72227 Binding of BTRC and AP1M2 1 0.00 0 0.49
17 INT269448 HHIP Positive_regulation of Binding of RAB5A 1 0.04 0 0.42
18 INT69109 Acot1 Regulation of Gene_expression of Serpine2 1 0.04 0 0.4
19 INT269456 RAB5A Regulation of Binding of HHIP 1 0.04 0 0.38
20 INT85782 Rb1 Regulation of PRKG1 1 0.00 0.38 0.37
21 INT85778 Rb1 Regulation of Prkaca 1 0.00 0.38 0.36
22 INT85779 Rb1 Regulation of Prkcg 1 0.01 0.38 0.36
23 INT94473 Binding of Cd3e and Trav6-3 2 0.05 0 0.34
24 INT94474 Binding of Cd3e and Il27ra 1 0.02 0 0.34
25 INT204080 HP Negative_regulation of Phosphorylation of Rb1 1 0.00 3.53 0.34
26 INT54943 Gab1 Regulation of Rb1 1 0.02 0.2 0.31
27 INT269459 Binding of ISYNA1 and HHIP 1 0.00 0 0.27
28 INT269490 Binding of Racgap1 and HHIP 1 0.00 0 0.27
29 INT277613 Binding of HDAC9 and Runx2 1 0.02 0.59 0.26
30 INT351143 Binding of Cd3e and Ighg2a 1 0.00 1.56 0.25
31 INT182346 Binding of Cd3e and Esr1 1 0.06 1.26 0.25
32 INT256656 Binding of EP300 and HHIP 1 0.22 0 0.24
33 INT72231 Negative_regulation of Binding of NFKBIL1 and BTRC 1 0.00 0 0.24
34 INT283948 SALL1 Positive_regulation of Positive_regulation of Ptgfrn 1 0.00 0.21 0.22
35 INT237201 Cd3e Positive_regulation of KIT 1 0.03 0 0.21
36 INT202809 Cd3e Positive_regulation of Positive_regulation of Cxcl5 1 0.00 0.5 0.21
37 INT269446 Binding of EPHA3 and HHIP 1 0.01 0 0.2
38 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
39 INT316072 Binding of Cd3e and Ncam1 1 0.01 0.4 0.18
40 INT316074 Binding of Cd19 and Cd3e 1 0.02 0.39 0.17
41 INT119264 Binding of RB1 and PPM1E 1 0.00 0.46 0.17
42 INT277990 Binding of Cd3e and Hand1 1 0.01 0.5 0.16
43 INT221899 Rb1 Positive_regulation of Transcription of Ccl20 1 0.01 0.62 0.16
44 INT221908 Rb1 Positive_regulation of Transcription of TNIP2 1 0.01 0.62 0.16
45 INT269451 Negative_regulation of Binding of RAB5A and HHIP 1 0.03 0 0.15
46 INT255258 Binding of Rb1 and Tsp1 1 0.38 0.95 0.15
47 INT75058 Negative_regulation of ACE Negative_regulation of HHIP 1 0.25 0.43 0.15
48 INT310263 Rb1 Negative_regulation of Gene_expression of Tnf 1 0.07 0.97 0.15
49 INT269452 RAB5A Regulation of Localization of HHIP 1 0.04 0 0.15
50 INT223963 Binding of Bglap and Runx2 1 0.14 1.74 0.13
51 INT269445 Localization of HHIP Regulation of Gene_expression of RAB5A 1 0.03 0 0.13
52 INT269457 RAB5A Regulation of Regulation of HHIP 1 0.02 0 0.13
53 INT311905 Binding of Runx2 and Smad1 1 0.12 0.46 0.13
54 INT211313 Binding of Cd3e and Cd8a 1 0.02 0.19 0.13
55 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
56 INT194814 Cd3e Positive_regulation of Gene_expression of Il4 1 0.05 0 0.12
57 INT269458 HHIP Regulation of Gene_expression of RAB5A 1 0.04 0 0.1
58 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
59 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
60 INT238392 RB1 Regulation of E2F2 1 0.01 0.36 0.08
61 INT255256 Positive_regulation of Binding of Rb1 and Tsp1 1 0.50 0.48 0.08
62 INT351142 Binding of Cd3e and Ighg2b 1 0.03 0.6 0.07
63 INT293220 Cd3e Regulation of Gene_expression of CNR2 1 0.03 0.06 0.06
64 INT76862 Dynll1 Positive_regulation of Rb1 1 0.37 0.1 0.06
65 INT293221 Cd3e Regulation of Gene_expression of CNR1 1 0.03 0.06 0.06
66 INT257867 Negative_regulation of Eif4e Positive_regulation of Rb1 1 0.05 0.54 0.06
67 INT197617 Binding of S100a6 and Rb1 1 0.03 0 0.06
68 INT237190 Cd3e Positive_regulation of LPT 1 0.00 0.15 0.06
69 INT298806 Binding of Hdac3 and Rb1 1 0.02 0.77 0.05
70 INT250865 Binding of Fgf8 and Fgfr3 1 0.18 0.3 0.05
71 INT178574 IL2RA Positive_regulation of Gene_expression of Cd3e 1 0.04 0.16 0.05
72 INT261964 fc Positive_regulation of Sall3 1 0.01 1.17 0.04
73 INT293353 Binding of CD8A and Cd3e 1 0.01 0.07 0.04
74 INT169962 Binding of Rb1 and E2f4 1 0.25 0.56 0.04
75 INT333848 Binding of Ccna1 and Rb1 1 0.04 0.48 0.04
76 INT269453 HHIP Positive_regulation of RAB5A 1 0.04 0 0.03
77 INT255756 Ptch1 Positive_regulation of Phosphorylation of Pik3r1 1 0.16 1.08 0.03
78 INT255733 Ptch1 Positive_regulation of Pik3r1 1 0.16 1.08 0.03
79 INT197587 Ppt1 Positive_regulation of Rb1 1 0.18 0 0.03
80 INT336404 Binding of Cd3e and ALPK1 1 0.01 0.55 0.03
81 INT197593 Dlat Positive_regulation of Rb1 1 0.04 0 0.03
82 INT94157 CDCP1 Negative_regulation of RB1 1 0.02 0.92 0.03
83 INT94159 Positive_regulation of CDK1 Negative_regulation of RB1 1 0.45 0.93 0.03
84 INT94158 CDK1 Negative_regulation of RB1 1 0.41 0.92 0.03
85 INT238393 Binding of E2F2 and RB1 3 0.04 0.24 0
86 INT225610 Ncoa6 Regulation of Rb1 1 0.03 0.21 0
87 INT255758 Ptch1 Positive_regulation of Akt1 1 0.21 1.14 0
88 INT301244 Rb1 Regulation of Hbp1 1 0.03 0.75 0
89 INT255732 Ptch1 Positive_regulation of hs 1 0.06 1.26 0
90 INT334322 Binding of RB1 and TP53 1 0.34 2 0
91 INT331089 Binding of Cd3e and Itga2 1 0.09 0.2 0
92 INT273774 Binding of GPER and RB1 1 0.01 0.45 0
93 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
94 INT305542 Binding of Rb1 and Trp53 1 0.00 0.9 0
95 INT169963 Positive_regulation of Binding of Rb1 and Rbl2 1 0.33 0.1 0
96 INT255755 Ptch1 Regulation of Positive_regulation of Ins1 1 0.05 0.28 0
97 INT306825 Positive_regulation of Binding of E2F2 and RB1 1 0.04 0.05 0
98 INT342265 Binding of VDR and HHIP 1 0.00 0.93 0
99 INT205958 GLI1 Positive_regulation of Gene_expression of PTCH1 1 0.35 0.57 0
100 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
101 INT321642 Binding of Cd3e and Spn 1 0.00 1.08 0
102 INT196958 Phosphorylation of Rb1 Positive_regulation of Localization of E2f1 1 0.45 0.44 0
103 INT169959 Binding of Rb1 and Rbl2 1 0.26 0.1 0
104 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
105 INT333448 RB1 Positive_regulation of TFDP1 1 0.05 0 0
106 INT330696 Phosphorylation of RB1 Positive_regulation of Gene_expression of E2F2 1 0.01 1 0
107 INT255753 Ptch1 Positive_regulation of Phosphorylation of Gopc 1 0.13 1.33 0
108 INT196955 Binding of E2f1 and Rb1 1 0.36 1 0
109 INT330698 PCNA Regulation of RB1 1 0.00 0.3 0
110 INT171248 Serpine2 Regulation of Gnrh1 1 0.21 0.07 0
111 INT314866 Binding of Six1 and Sall1 1 0.39 0.76 0
112 INT196943 E2f1 Negative_regulation of Rb1 1 0.42 0.44 0
113 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0
114 INT196961 Binding of Hmga2 and Rb1 1 0.48 6.47 0
115 INT256632 Binding of PTCH1 and Jkamp 1 0.00 2.32 0
116 INT171247 Serpine2 Regulation of Gene_expression of Gnrh1 1 0.21 0 0
117 INT255744 Binding of hs and Ptch1 1 0.06 1.32 0
118 INT277610 Binding of Runx2 and Hdac4 1 0.32 0.78 0
119 INT247427 CDKN2A Negative_regulation of Negative_regulation of RB1 1 0.07 1.16 0
120 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
121 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
122 INT255750 Ptch1 Positive_regulation of Ins1 1 0.10 0.35 0
123 INT260073 Binding of FANCC and PTCH1 1 0.33 0.49 0
124 INT196950 Binding of Rb1 and E2f2 1 0.01 0.6 0
125 INT196947 Binding of Rb1 and Positive_regulation of Hmga2 1 0.50 0.3 0
126 INT355309 Positive_regulation of Binding of Cd3e and Cd5 1 0.03 2 0
127 INT260067 Binding of PTCH1 and XPA 1 0.26 1.08 0
128 INT205976 Binding of Ptch1 and SMOX 1 0.21 0.72 0
129 INT205962 Binding of PTCH1 and SMOX 1 0.14 0.72 0
130 INT196941 Hdac1 Negative_regulation of Rb1 1 0.27 0.44 0
131 INT196945 Rb1 Negative_regulation of Transcription of E2f1 1 0.42 0.35 0
132 INT196944 Binding of Rb1 and Hdac1 1 0.24 0.4 0
133 INT301366 Fgf18 Positive_regulation of Fgfr3 1 0.04 0.34 0
134 INT305336 TP53 Negative_regulation of Phosphorylation of RB1 1 0.29 0.96 0
135 INT255734 Ptch1 Regulation of Ins1 1 0.09 1.46 0
136 INT313481 Binding of Cd3e and Epcam 1 0.19 0.81 0
137 INT255760 Ptch1 Regulation of TNF 1 0.13 1.33 0
138 INT255741 Ptch1 Positive_regulation of Phosphorylation of Ins1 1 0.09 2.21 0
139 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
140 INT205961 GLI1 Positive_regulation of Negative_regulation of PTCH1 1 0.25 0.58 0
141 INT243232 Ighmbp2 Negative_regulation of Ptch1 1 0.02 0.22 0
142 INT196953 Hmga2 Negative_regulation of Rb1 1 0.59 0.35 0
143 INT355314 Binding of Cd3e and Cd5 1 0.02 1.99 0
144 INT255749 Ptch1 Positive_regulation of Phosphorylation of Slc2a4 1 0.15 1.32 0
145 INT255735 Ptch1 Positive_regulation of Phosphorylation of Akt1 1 0.27 2.83 0
146 INT255746 Hspa1a Positive_regulation of Positive_regulation of Ptch1 1 0.19 0.99 0
147 INT255739 Ptch1 Positive_regulation of Gene_expression of Hspa1a 1 0.18 0.75 0
148 INT255759 Ptch1 Positive_regulation of Phosphorylation of hs 1 0.06 1.34 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of smoothened signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of smoothened signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16321 Gene_expression of Cd3e 111 0.72 49.9 14.21
2 INT125477 Gene_expression of HHIP 91 0.78 31.18 12.57
3 INT178763 Binding of HHIP 37 0.08 6.3 5.29
4 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
5 INT125478 Localization of HHIP 32 0.80 3.43 4.68
6 INT125479 Positive_regulation of HHIP 38 0.44 12.39 3.75
7 INT25386 Positive_regulation of Cd3e 30 0.62 13.91 3.41
8 INT94164 Phosphorylation of RB1 83 0.80 48.84 3.21
9 INT36286 Binding of Cd3e 33 0.36 10.11 3.21
10 INT29929 Gene_expression of Rb1 20 0.69 5.81 3.1
11 INT54749 Binding of BTRC 7 0.09 0.88 2.9
12 INT69099 Gene_expression of Serpine2 22 0.78 7.89 2.87
13 INT54938 Regulation of Rb1 6 0.44 4.41 2.69
14 INT224826 Gene_expression of SALL1 1 0.55 1.94 2.57
15 INT142120 Gene_expression of Runx2 45 0.77 15.76 2.55
16 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
17 INT57970 Positive_regulation of Rb1 17 0.67 7.03 2.36
18 INT73266 Gene_expression of RB1 50 0.70 29.09 2.31
19 INT172078 Localization of Cd3e 22 0.37 9.88 2.27
20 INT125480 Regulation of HHIP 17 0.38 6.16 2.16
21 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
22 INT57971 Regulation of Rb1 5 0.41 2.36 1.66
23 INT94169 Negative_regulation of Phosphorylation of RB1 16 0.41 8.87 1.57
24 INT54750 Gene_expression of BTRC 4 0.14 0.99 1.55
25 INT140245 Binding of Gli3 3 0.36 2.65 1.46
26 INT113151 Positive_regulation of Ptch1 7 0.64 3.8 1.41
27 INT169907 Gene_expression of Rb1 25 0.60 21.95 1.32
28 INT70954 Negative_regulation of Cd3e 11 0.41 4.22 1.31
29 INT139077 Negative_regulation of Ptch1 5 0.56 5.22 1.29
30 INT63905 Regulation of RB1 13 0.62 12.67 1.28
31 INT22815 Positive_regulation of RB1 20 0.49 14.58 1.26
32 INT41124 Negative_regulation of Rb1 11 0.44 3.17 1.22
33 INT125476 Regulation of Gene_expression of HHIP 2 0.39 1.1 1.1
34 INT269487 Positive_regulation of Binding of HHIP 1 0.06 0 1.08
35 INT43484 Binding of Runx2 7 0.37 3.22 0.95
36 INT174188 Positive_regulation of Gene_expression of RB1 9 0.45 6.22 0.94
37 INT269485 Positive_regulation of Gene_expression of HHIP 9 0.41 1.08 0.92
38 INT135299 Binding of PTCH1 10 0.48 12.16 0.84
39 INT224830 Positive_regulation of Gene_expression of SALL1 1 0.41 0.64 0.81
40 INT169911 Phosphorylation of Rb1 35 0.73 18.58 0.79
41 INT174492 Positive_regulation of Gene_expression of Cd3e 8 0.39 5.08 0.77
42 INT118469 Gene_expression of Fgfr3 5 0.72 6.98 0.75
43 INT142416 Binding of Ptch1 6 0.34 4.92 0.74
44 INT41123 Positive_regulation of Rb1 12 0.44 3.03 0.73
45 INT131240 Gene_expression of Sall3 5 0.65 0.32 0.68
46 INT68560 Regulation of Gli3 3 0.18 1.51 0.68
47 INT153257 Regulation of Ptch1 6 0.36 5.92 0.67
48 INT112649 Negative_regulation of Serpine2 10 0.43 1.41 0.66
49 INT142123 Positive_regulation of Gene_expression of Runx2 17 0.64 4.81 0.65
50 INT169931 Localization of Rb1 6 0.70 4.79 0.65
51 INT269461 Positive_regulation of Localization of HHIP 1 0.05 0 0.63
52 INT269465 Positive_regulation of Positive_regulation of HHIP 4 0.11 0.5 0.62
53 INT224827 Regulation of SALL1 2 0.37 3.36 0.62
54 INT69100 Regulation of Gene_expression of Serpine2 1 0.18 0 0.59
55 INT65919 Gene_expression of Ptch1 11 0.75 6.47 0.56
56 INT62266 Phosphorylation of Rb1 4 0.71 2.68 0.54
57 INT135062 Transcription of Gli3 1 0.05 0 0.52
58 INT94165 Negative_regulation of RB1 30 0.52 27.29 0.51
59 INT93397 Negative_regulation of Phosphorylation of Rb1 1 0.51 0.32 0.48
60 INT172077 Positive_regulation of Localization of Cd3e 3 0.09 3.18 0.47
61 INT112651 Positive_regulation of Gene_expression of Serpine2 3 0.70 3.36 0.47
62 INT155265 Regulation of Cd3e 7 0.17 2.62 0.46
63 INT178766 Negative_regulation of HHIP 19 0.28 11.1 0.43
64 INT85854 Binding of SALL1 5 0.36 1.4 0.41
65 INT194993 Binding of RB1 15 0.37 10.96 0.4
66 INT196916 Negative_regulation of Rb1 13 0.42 14.29 0.4
67 INT41125 Positive_regulation of Localization of Rb1 2 0.38 0.78 0.39
68 INT41126 Localization of Rb1 2 0.61 0.78 0.39
69 INT196925 Positive_regulation of Gene_expression of Rb1 4 0.45 3.16 0.33
70 INT187790 Negative_regulation of Gene_expression of Serpine2 2 0.37 1.23 0.33
71 INT169918 Negative_regulation of Phosphorylation of Rb1 8 0.37 6.64 0.32
72 INT198170 Positive_regulation of SALL1 4 0.49 1.5 0.32
73 INT197599 Transcription of Rb1 4 0.63 0.87 0.3
74 INT171220 Regulation of Serpine2 3 0.20 0.1 0.28
75 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26
76 INT283300 Transcription of Serpine2 1 0.06 0.67 0.25
77 INT135061 Protein_catabolism of Gli3 1 0.04 0 0.25
78 INT72235 Negative_regulation of BTRC 3 0.02 0 0.24
79 INT278687 Regulation of Positive_regulation of Cd3e 1 0.10 0.51 0.23
80 INT142117 Regulation of Runx2 6 0.61 2.75 0.22
81 INT207163 Regulation of Gene_expression of Rb1 3 0.39 1.08 0.22
82 INT269484 Negative_regulation of Localization of HHIP 1 0.04 0 0.22
83 INT269463 Phosphorylation of HHIP 1 0.05 0 0.22
84 INT269489 Positive_regulation of Phosphorylation of HHIP 1 0.04 0 0.22
85 INT131243 Positive_regulation of Sall3 2 0.45 1.34 0.2
86 INT171614 Positive_regulation of Runx2 13 0.63 3.04 0.19
87 INT123265 Negative_regulation of SALL1 3 0.18 0.78 0.19
88 INT135060 Negative_regulation of Transcription of Gli3 1 0.03 0 0.19
89 INT293677 Transcription of RB1 1 0.62 0.8 0.18
90 INT171605 Negative_regulation of Runx2 4 0.46 2.14 0.17
91 INT169930 Binding of Rb1 15 0.43 5.91 0.16
92 INT269464 Negative_regulation of Gene_expression of HHIP 4 0.10 0.74 0.16
93 INT131242 Positive_regulation of Gene_expression of Sall3 1 0.49 0.19 0.16
94 INT94168 Positive_regulation of Phosphorylation of RB1 12 0.60 6.6 0.15
95 INT269486 Regulation of Localization of HHIP 1 0.04 0 0.15
96 INT197627 Localization of RB1 3 0.69 4.16 0.13
97 INT314724 Regulation of Localization of RB1 1 0.15 1.25 0.13
98 INT190563 Regulation of Binding of Rb1 1 0.08 0.7 0.13
99 INT169940 Positive_regulation of Localization of Rb1 2 0.61 1.74 0.11
100 INT171236 Localization of Serpine2 2 0.42 0.35 0.11
101 INT211285 Positive_regulation of Positive_regulation of Cd3e 1 0.25 0.35 0.11
102 INT270451 Localization of Gli3 1 0.26 0.63 0.11
103 INT211299 Regulation of Gene_expression of Cd3e 3 0.23 0.79 0.1
104 INT329940 Gene_expression of Sall1 1 0.02 0 0.1
105 INT260083 Regulation of PTCH1 11 0.27 4.46 0.09
106 INT257732 Regulation of Positive_regulation of RB1 2 0.39 2.35 0.09
107 INT270454 Regulation of Transcription of Ptch1 1 0.25 0.55 0.09
108 INT70955 Negative_regulation of Negative_regulation of Cd3e 1 0.41 0.47 0.09
109 INT312847 Regulation of Localization of Cd3e 1 0.06 1.61 0.09
110 INT135063 Regulation of Gene_expression of Gli3 1 0.04 0 0.09
111 INT270450 Transcription of Ptch1 1 0.49 0.55 0.09
112 INT211942 Transcription of Runx2 3 0.69 2.46 0.08
113 INT165148 Regulation of Binding of Ptch1 1 0.22 0.08 0.08
114 INT126375 Negative_regulation of Gene_expression of Gli3 1 0.58 0.79 0.08
115 INT270452 Regulation of Gene_expression of Ptch1 1 0.25 0.25 0.08
116 INT250839 Binding of Fgfr3 1 0.16 0.19 0.08
117 INT180504 Phosphorylation of Cd3e 2 0.49 0.38 0.07
118 INT62267 Negative_regulation of Gene_expression of Rb1 1 0.12 0.82 0.07
119 INT62265 Negative_regulation of Positive_regulation of Rb1 1 0.12 0.85 0.07
120 INT180505 Positive_regulation of Phosphorylation of Cd3e 1 0.06 0.38 0.07
121 INT224825 Regulation of Gene_expression of SALL1 1 0.37 0.07 0.07
122 INT165154 Negative_regulation of Positive_regulation of Ptch1 1 0.34 0.09 0.07
123 INT183056 Positive_regulation of Transcription of PTCH1 1 0.28 0.46 0.07
124 INT197606 Binding of Rb1 2 0.28 0.14 0.06
125 INT255719 Phosphorylation of Ptch1 1 0.32 3.7 0.06
126 INT171226 Positive_regulation of Serpine2 2 0.40 0.22 0.05
127 INT255726 Localization of Ptch1 1 0.33 1.74 0.05
128 INT183070 Transcription of PTCH1 2 0.68 0.95 0.04
129 INT260808 Negative_regulation of Gene_expression of Cd3e 2 0.21 0.81 0.04
130 INT245909 Positive_regulation of Transcription of Rb1 1 0.05 0.49 0.04
131 INT330788 Protein_catabolism of Cd3e 1 0.07 0 0.04
132 INT236701 Negative_regulation of Gene_expression of Rb1 4 0.10 4.55 0.03
133 INT169945 Positive_regulation of Phosphorylation of Rb1 4 0.41 1.75 0.03
134 INT265385 Negative_regulation of Binding of Cd3e 1 0.04 0.23 0.03
135 INT183064 Regulation of Gene_expression of PTCH1 1 0.34 0.22 0.03
136 INT298776 Regulation of Phosphorylation of Rb1 1 0.04 0.39 0.03
137 INT174197 Negative_regulation of Gene_expression of RB1 4 0.47 4.25 0
138 INT205968 Negative_regulation of PTCH1 2 0.58 2.35 0
139 INT348463 Protein_catabolism of RB1 2 0.11 2.22 0
140 INT225170 Regulation of Phosphorylation of RB1 2 0.36 1.12 0
141 INT255723 Positive_regulation of Gene_expression of Ptch1 2 0.39 1.3 0
142 INT225167 Negative_regulation of Binding of RB1 2 0.34 1.25 0
143 INT247431 Positive_regulation of Negative_regulation of RB1 2 0.45 2.58 0
144 INT142118 Regulation of Gene_expression of Runx2 2 0.61 2.92 0
145 INT276327 Positive_regulation of Gene_expression of Fgfr3 2 0.43 1.83 0
146 INT211290 Regulation of Binding of Cd3e 2 0.23 0 0
147 INT256631 Positive_regulation of PTCH1 2 0.13 1.97 0
148 INT196935 Negative_regulation of Binding of Rb1 1 0.38 0.24 0
149 INT279810 Negative_regulation of Positive_regulation of SALL1 1 0.03 0.07 0
150 INT342268 Positive_regulation of Negative_regulation of HHIP 1 0.04 0.91 0
151 INT211944 Regulation of Transcription of Runx2 1 0.34 0.32 0
152 INT243057 Positive_regulation of Fgfr3 1 0.46 0.79 0
153 INT303553 Regulation of Gene_expression of Fgfr3 1 0.25 0.3 0
154 INT260088 Negative_regulation of Transcription of PTCH1 1 0.43 0.4 0
155 INT197596 Negative_regulation of Transcription of Rb1 1 0.38 0.22 0
156 INT349060 Regulation of Negative_regulation of HHIP 1 0.10 1.33 0
157 INT243058 Positive_regulation of Positive_regulation of Fgfr3 1 0.46 0.8 0
158 INT293681 Positive_regulation of Positive_regulation of RB1 1 0.39 0.27 0
159 INT197608 Positive_regulation of Gene_expression of Rb1 1 0.44 0 0
160 INT294502 Transcription of Cd3e 1 0.27 0 0
161 INT293672 Positive_regulation of Transcription of RB1 1 0.45 0.4 0
162 INT260089 Localization of PTCH1 1 0.70 0.37 0
163 INT196910 Positive_regulation of Binding of Rb1 1 0.45 0.81 0
164 INT273783 Regulation of Gene_expression of RB1 1 0.29 0.67 0
165 INT233766 Negative_regulation of Regulation of HHIP 1 0.12 0.32 0
166 INT270455 Negative_regulation of Gene_expression of Ptch1 1 0.39 0.66 0
167 INT204055 Positive_regulation of Negative_regulation of Rb1 1 0.03 0.55 0
168 INT269469 Regulation of Positive_regulation of HHIP 1 0.04 0 0
169 INT265814 Localization of Runx2 1 0.75 0.84 0
170 INT171229 Binding of Serpine2 1 0.22 0.06 0
171 INT301359 Positive_regulation of Fgfr3 1 0.19 0.64 0
172 INT277589 Regulation of Negative_regulation of Runx2 1 0.36 0.78 0
173 INT301453 Positive_regulation of Sall1 1 0.04 0.08 0
174 INT265813 Regulation of Binding of Runx2 1 0.27 0.19 0
175 INT301357 Negative_regulation of Positive_regulation of Fgfr3 1 0.16 0.35 0
176 INT171227 Negative_regulation of Regulation of Serpine2 1 0.26 0 0
177 INT171613 Positive_regulation of Positive_regulation of Runx2 1 0.01 0 0
178 INT297392 Positive_regulation of Binding of SALL1 1 0.49 0 0
179 INT183052 Positive_regulation of Gene_expression of PTCH1 1 0.38 0.26 0
180 INT260080 Negative_regulation of Gene_expression of PTCH1 1 0.58 2.09 0
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