GO:0045880

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Name positive regulation of smoothened signaling pathway
Categary Process
Go Slim No
Go Link GO:0045880
Unique Molecular Interactions 109
Total Molecular Interactions 150
Total Single Events 719
Pain Genes Associated 17

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of smoothened signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of smoothened signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
2 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
3 INT297340 Apoe Regulation of Binding of Smo 1 0.10 1.1 0.6
4 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
5 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
6 INT297342 Binding of Gnb5 and Smo 1 0.02 1.67 0.34
7 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33
8 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
9 INT149895 Ihh Regulation of Localization of Mmp7 1 0.03 0.98 0.33
10 INT149902 Ihh Positive_regulation of SGCG 1 0.45 0.76 0.32
11 INT5935 Por Regulation of Oprm1 1 0.19 0.51 0.28
12 INT149898 Ihh Regulation of Localization of Mmp14 1 0.03 1.29 0.27
13 INT210798 Ihh Positive_regulation of Itgbl1 1 0.34 0 0.23
14 INT149900 Gli1 Regulation of Localization of Mmp14 1 0.02 1.17 0.22
15 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
16 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
17 INT210782 Ihh Negative_regulation of Itgbl1 1 0.31 0 0.16
18 INT210804 Ihh Negative_regulation of Timp4 1 0.32 0 0.16
19 INT184704 Binding of Prrx2 and Sr1 1 0.21 1.65 0.13
20 INT345343 PTCH1 Regulation of Negative_regulation of SMO 1 0.09 2.3 0.13
21 INT273018 Binding of FGF9 and PDE1A 1 0.18 0.3 0.11
22 INT273020 Binding of FGF9 and PDE11A 1 0.22 0.3 0.11
23 INT24321 Pomc Positive_regulation of Localization of Gli1 1 0.07 0 0.1
24 INT262751 Binding of PTCH1 and SMO 1 0.25 1.29 0.1
25 INT165161 Ihh Positive_regulation of Sostdc1 1 0.58 0.07 0.09
26 INT165159 Gli1 Regulation of Penk 1 0.24 0.07 0.09
27 INT165160 Regulation of Ihh Positive_regulation of Sostdc1 1 0.23 0.07 0.09
28 INT165158 Positive_regulation of Ihh Positive_regulation of Sostdc1 1 0.42 0.07 0.09
29 INT352611 Trp53 Negative_regulation of Localization of Gli1 1 0.23 1.2 0.09
30 INT238472 Binding of AVP and POR 1 0.02 0.85 0.09
31 INT165157 Gli1 Regulation of Igfbp5 1 0.24 0.07 0.09
32 INT342232 Binding of POR and SEPP1 1 0.02 0.75 0.08
33 INT270457 Binding of Ptch1 and Gli1 1 0.02 1.3 0.08
34 INT210788 Ihh Negative_regulation of Coro1a 1 0.02 0 0.08
35 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
36 INT210790 Ihh Negative_regulation of Cdkn1c 1 0.30 0 0.08
37 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
38 INT210787 Ihh Negative_regulation of Nr3c1 1 0.33 0 0.08
39 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
40 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
41 INT352621 Gli1 Negative_regulation of Trp53 1 0.32 0.56 0.05
42 INT262757 SMO Positive_regulation of Regulation of GLI1 1 0.34 0.6 0.04
43 INT270458 Binding of Gli1 and Smo 1 0.00 0.65 0.04
44 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
45 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
46 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
47 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
48 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
49 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
50 INT264979 Binding of POR and BAG3 1 0.15 0.38 0
51 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
52 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
53 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
54 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
55 INT355588 Binding of CDH1 and CTNNA1 1 0.00 1.12 0
56 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
57 INT293982 MYC Negative_regulation of SFRP1 1 0.21 0.62 0
58 INT205975 Binding of PTCH1 and Smo 1 0.02 0.72 0
59 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
60 INT333294 Binding of Zic2 and Gli1 1 0.03 0 0
61 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
62 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
63 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0
64 INT205974 Smo Positive_regulation of GLI1 1 0.04 0.66 0
65 INT205958 GLI1 Positive_regulation of Gene_expression of PTCH1 1 0.35 0.57 0
66 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
67 INT352525 SLC25A16 Negative_regulation of SMO 1 0.00 1.1 0
68 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
69 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
70 INT289372 Negative_regulation of Gli1 Positive_regulation of cac 1 0.48 0.68 0
71 INT205964 SMOX Positive_regulation of GLI1 1 0.20 0.66 0
72 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
73 INT333293 Binding of Zic1 and Gli1 1 0.01 0 0
74 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
75 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
76 INT342558 FGF9 Positive_regulation of MAPK3 1 0.03 1.21 0
77 INT342555 FGF9 Positive_regulation of MAPK1 1 0.07 1.22 0
78 INT315194 Binding of SFRP1 and Slc10a1 1 0.02 8.85 0
79 INT289373 Gli1 Positive_regulation of cac 1 0.52 0.68 0
80 INT205965 Binding of Ptch1 and Smo 1 0.03 0.72 0
81 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
82 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
83 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
84 INT304023 SFRP1 Regulation of Binding of MSI1 1 0.04 1.78 0
85 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
86 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
87 INT205961 GLI1 Positive_regulation of Negative_regulation of PTCH1 1 0.25 0.58 0
88 INT315187 Binding of SFRP1 and COPD 1 0.01 4.47 0
89 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
90 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
91 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
92 INT197793 Pthlh Regulation of Ihh 1 0.22 1.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of smoothened signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of smoothened signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113041 Gene_expression of IHH 9 0.78 5.83 2.87
2 INT38384 Regulation of Por 5 0.47 0.58 2.4
3 INT12131 Gene_expression of POR 17 0.77 9.42 2.17
4 INT184676 Transcription of Prrx2 1 0.37 3.64 2.02
5 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
6 INT59302 Positive_regulation of POR 19 0.49 15.18 1.95
7 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
8 INT184683 Gene_expression of Prrx2 1 0.37 7.9 1.5
9 INT151 Positive_regulation of Por 5 0.62 0.42 1.31
10 INT49013 Gene_expression of Por 6 0.75 2.19 1.22
11 INT183068 Gene_expression of SMO 2 0.17 0.27 1.2
12 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15
13 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
14 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
15 INT115821 Transcription of Por 1 0.33 0.51 1.02
16 INT49012 Regulation of Gene_expression of Por 1 0.44 0 1.02
17 INT184698 Positive_regulation of Prrx2 1 0.38 3.21 1.01
18 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
19 INT270447 Binding of Smo 2 0.07 2.61 0.78
20 INT126376 Gene_expression of Gli1 8 0.68 4.52 0.7
21 INT58960 Regulation of POR 5 0.25 1.04 0.68
22 INT47038 Gene_expression of SFRP1 14 0.67 9.6 0.63
23 INT113042 Localization of IHH 1 0.70 0.77 0.61
24 INT205957 Negative_regulation of Smo 4 0.08 2.57 0.6
25 INT111601 Negative_regulation of Gene_expression of CTNNA1 1 0.24 0.58 0.58
26 INT111609 Gene_expression of CTNNA1 3 0.46 3.2 0.57
27 INT140984 Regulation of Ihh 5 0.54 2.81 0.56
28 INT40164 Binding of Por 2 0.37 0.5 0.51
29 INT24317 Gene_expression of Gli1 4 0.54 1.46 0.47
30 INT135366 Localization of SFRP1 4 0.75 1.82 0.47
31 INT111606 Positive_regulation of CTNNA1 1 0.12 0.47 0.47
32 INT206484 Localization of Shh 2 0.75 1.14 0.46
33 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
34 INT265 Negative_regulation of Por 4 0.59 0.34 0.41
35 INT149890 Positive_regulation of Gene_expression of Gli1 1 0.48 1.56 0.41
36 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
37 INT12249 Binding of POR 5 0.35 2.76 0.35
38 INT40753 Gene_expression of GLI1 9 0.75 5.98 0.33
39 INT166716 Negative_regulation of Ihh 3 0.43 0.67 0.33
40 INT356400 Transcription of Smo 1 0.02 0.05 0.3
41 INT24320 Localization of Gli1 6 0.77 0.63 0.29
42 INT277474 Positive_regulation of Gene_expression of SMO 1 0.11 0 0.29
43 INT12132 Positive_regulation of Gene_expression of POR 5 0.31 1.96 0.27
44 INT216120 Negative_regulation of SMO 2 0.49 3.05 0.27
45 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
46 INT149893 Positive_regulation of Gene_expression of Ihh 1 0.69 0.62 0.26
47 INT149892 Gene_expression of Ihh 1 0.77 0.61 0.26
48 INT165153 Positive_regulation of Gli1 4 0.59 1.17 0.25
49 INT184670 Localization of Prrx2 1 0.35 0.23 0.24
50 INT184671 Positive_regulation of Localization of Prrx2 1 0.24 0.23 0.24
51 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
52 INT254040 Regulation of FGF9 2 0.57 1.04 0.21
53 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
54 INT149888 Localization of Ihh 1 0.75 0.77 0.2
55 INT24316 Regulation of Localization of Gli1 1 0.51 0 0.19
56 INT64189 Protein_catabolism of POR 1 0.37 0.16 0.18
57 INT139662 Gene_expression of FGF9 7 0.65 2.26 0.17
58 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
59 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
60 INT278241 Regulation of IHH 2 0.31 1.16 0.14
61 INT184674 Negative_regulation of Prrx2 1 0.23 3.14 0.14
62 INT149891 Negative_regulation of Gene_expression of Gli1 1 0.41 0.68 0.14
63 INT253190 Localization of Shh 2 0.77 1.06 0.13
64 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
65 INT115825 Positive_regulation of Gene_expression of Por 2 0.22 0.47 0.12
66 INT167018 Negative_regulation of POR 3 0.37 1.9 0.11
67 INT184669 Positive_regulation of Transcription of Prrx2 1 0.27 2.71 0.1
68 INT115833 Negative_regulation of Transcription of Por 1 0.20 0.52 0.09
69 INT270442 Transcription of Shh 1 0.53 0.25 0.09
70 INT24318 Regulation of Gene_expression of Gli1 1 0.23 0 0.09
71 INT115828 Negative_regulation of Gene_expression of Por 1 0.20 0.52 0.09
72 INT213515 Binding of Shh 8 0.37 1.92 0.08
73 INT210805 Negative_regulation of IHH 2 0.42 0.74 0.08
74 INT270453 Regulation of Shh 1 0.27 0.83 0.08
75 INT184689 Regulation of Prrx2 1 0.13 0.77 0.08
76 INT352606 Localization of Gli1 1 0.38 1.19 0.08
77 INT205973 Binding of SHH 3 0.35 1.03 0.07
78 INT165151 Negative_regulation of Positive_regulation of Gli1 1 0.50 0.09 0.07
79 INT168919 Regulation of Regulation of Ihh 1 0.40 0.43 0.07
80 INT256862 Regulation of Shh 1 0.25 0 0.07
81 INT67606 Localization of POR 3 0.68 1.22 0.06
82 INT345344 Regulation of SMO 1 0.23 1.07 0.06
83 INT206866 Positive_regulation of SFRP1 7 0.51 3.97 0.05
84 INT287913 Positive_regulation of Gene_expression of SFRP1 2 0.25 2.12 0.05
85 INT290112 Positive_regulation of Gene_expression of Gli1 1 0.50 1.09 0.05
86 INT290114 Negative_regulation of Gene_expression of Gli1 1 0.31 1.09 0.05
87 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
88 INT251811 Positive_regulation of IHH 1 0.29 0.09 0.05
89 INT262772 Binding of SMO 1 0.27 0.59 0.05
90 INT205969 Regulation of GLI1 4 0.41 3.09 0.04
91 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
92 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
93 INT262777 Localization of SMO 1 0.59 0.6 0.04
94 INT352603 Negative_regulation of Localization of Gli1 1 0.18 0.6 0.04
95 INT270456 Positive_regulation of Gli1 1 0.02 0.62 0.04
96 INT352604 Regulation of Gli1 1 0.21 0.6 0.04
97 INT184682 Negative_regulation of Gene_expression of Prrx2 1 0.23 1.5 0.04
98 INT165149 Positive_regulation of Ihh 1 0.42 0.09 0.04
99 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
100 INT253181 Transcription of Shh 1 0.68 0.54 0.03
101 INT294470 Transcription of IHH 1 0.16 0.28 0.03
102 INT226288 Negative_regulation of SFRP1 6 0.43 4.45 0
103 INT273600 Positive_regulation of FGF9 2 0.15 1.46 0
104 INT246011 Transcription of Gli1 2 0.29 0 0
105 INT205972 Regulation of Gene_expression of GLI1 1 0.41 1.17 0
106 INT342561 Negative_regulation of FGF9 1 0.09 0.78 0
107 INT268585 Negative_regulation of Gene_expression of GLI1 1 0.24 1.01 0
108 INT323616 Phosphorylation of POR 1 0.05 0.7 0
109 INT323617 Positive_regulation of Phosphorylation of POR 1 0.03 0.7 0
110 INT252242 Gene_expression of Smo 1 0.01 0.23 0
111 INT139665 Transcription of FGF9 1 0.04 0.11 0
112 INT264980 Transcription of POR 1 0.38 0.73 0
113 INT322888 Negative_regulation of Ihh 1 0.26 0.45 0
114 INT315189 Binding of SFRP1 1 0.15 2.96 0
115 INT342565 Localization of FGF9 1 0.16 0.79 0
116 INT226287 Regulation of Gene_expression of SFRP1 1 0.38 0.37 0
117 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
118 INT355598 Negative_regulation of CTNNA1 1 0.04 1.06 0
119 INT24319 Positive_regulation of Localization of Gli1 1 0.66 0 0
120 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
121 INT205956 Localization of Smo 1 0.06 0.71 0
122 INT290929 Binding of Shh 1 0.31 0.1 0
123 INT205967 Localization of GLI1 1 0.50 0.57 0
124 INT226286 Negative_regulation of Gene_expression of SFRP1 1 0.31 0.7 0
125 INT268570 Positive_regulation of Gene_expression of GLI1 1 0.19 0.97 0
126 INT268563 Transcription of GLI1 1 0.29 0.91 0
127 INT294017 Negative_regulation of Localization of SFRP1 1 0.32 0.47 0
128 INT342569 Positive_regulation of Gene_expression of FGF9 1 0.11 1.05 0
129 INT191529 Negative_regulation of Positive_regulation of POR 1 0.02 1.5 0
130 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
131 INT139659 Binding of FGF9 1 0.02 0.13 0
132 INT289370 Binding of Gli1 1 0.37 2.78 0
133 INT301356 Binding of Ihh 1 0.08 0.06 0
134 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
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