GO:0045926

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Name negative regulation of growth
Categary Process
Go Slim No
Go Link GO:0045926
Unique Molecular Interactions 90
Total Molecular Interactions 107
Total Single Events 1043
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of growth. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of growth. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT44504 Mt1a Positive_regulation of Prl 1 0.37 0 1.48
2 INT44502 Regulation of Mt1a Positive_regulation of Prl 1 0.14 0 0.74
3 INT100369 HIF1A Positive_regulation of Positive_regulation of VEGFA 1 0.29 0.99 0.62
4 INT135176 Myst2 Regulation of Gene_expression of Hif1a 1 0.24 0.47 0.47
5 INT254360 Binding of EPAS1 and HIF1A 3 0.39 3.36 0.46
6 INT135178 Myst2 Regulation of Hif1a 1 0.24 0.44 0.44
7 INT56577 Mt1a Positive_regulation of Localization of Gnrh1 1 0.04 0 0.43
8 INT198647 TNF Positive_regulation of HIF1A 1 0.03 2.97 0.34
9 INT297972 MAPK14 Negative_regulation of ING5 1 0.21 1.67 0.33
10 INT254349 Positive_regulation of Binding of EPAS1 and HIF1A 1 0.00 0.92 0.23
11 INT162850 ISYNA1 Positive_regulation of Localization of HIF1A 1 0.05 0.25 0.21
12 INT305003 HIF1A Regulation of SERPINE1 1 0.11 2.3 0.19
13 INT198649 Binding of HIF1A and MIF 1 0.01 1.53 0.18
14 INT143440 HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.52 0.45 0.17
15 INT181898 Binding of ROS1 and Positive_regulation of HIF1A 1 0.02 0.82 0.15
16 INT181897 ROS1 Negative_regulation of HIF1A 1 0.03 0.83 0.15
17 INT237418 Binding of Hif1a and Bace1 1 0.06 1.18 0.15
18 INT181895 ROS1 Positive_regulation of HIF1A 1 0.03 0.78 0.15
19 INT181894 ROS1 Regulation of HIF1A 1 0.02 0.82 0.13
20 INT243308 Binding of LAMP2 and BBC3 1 0.08 0.59 0.13
21 INT243319 Binding of ATP6V0A1 and BBC3 1 0.07 0.59 0.13
22 INT323434 Osr1 Regulation of Hif1a 1 0.01 0.79 0.13
23 INT198671 HIF1A Regulation of Positive_regulation of Epo 1 0.00 1.37 0.13
24 INT323433 Osr1 Regulation of Protein_catabolism of Hif1a 1 0.01 0.8 0.13
25 INT232787 CYBB Positive_regulation of Positive_regulation of Hif1a 1 0.01 0.66 0.12
26 INT323431 Binding of Hif1a and Vhl 1 0.07 0.68 0.12
27 INT249923 Binding of Pah and Hif1a 1 0.31 1.16 0.12
28 INT305002 Binding of HIF1A and SERPINE1 1 0.07 1.17 0.11
29 INT199583 HIF1A Positive_regulation of Gene_expression of Vhl 1 0.26 1.39 0.11
30 INT312305 Binding of HIF1A and Positive_regulation of Transcription of VEGFA 1 0.17 2.8 0.1
31 INT102244 IL36RN Positive_regulation of Binding of HIF1A 1 0.06 1.07 0.1
32 INT102245 TNF Positive_regulation of Binding of HIF1A 1 0.18 1.09 0.1
33 INT102248 INS Positive_regulation of Binding of HIF1A 1 0.13 0.96 0.1
34 INT294455 KLK4 Negative_regulation of HIF1A 1 0.01 0 0.1
35 INT102246 Binding of HIF1A and INS 1 0.07 0.96 0.1
36 INT173061 Binding of HIF1A and LILRA3 1 0.03 1.24 0.09
37 INT173062 Binding of HIF1A and VHLL 1 0.04 1.26 0.09
38 INT94523 Binding of MT2A and ALG1 1 0.16 0.72 0.09
39 INT173057 Positive_regulation of HIF1A Positive_regulation of Gene_expression of VEGFA 1 0.24 1.49 0.08
40 INT249920 Negative_regulation of Binding of Pah and Hif1a 1 0.37 0.76 0.08
41 INT178081 Negative_regulation of EDN1 Positive_regulation of HIF1A 1 0.04 1.18 0.08
42 INT178078 Positive_regulation of Binding of DBP and HIF1A 1 0.00 1 0.08
43 INT178080 EDN1 Positive_regulation of HIF1A 1 0.05 1.05 0.08
44 INT178103 Binding of DBP and HIF1A 1 0.00 0.99 0.07
45 INT247578 Hif1a Regulation of VEGFA 1 0.02 1.59 0.07
46 INT308328 Hif1a Regulation of Positive_regulation of Trib3 1 0.02 0.89 0.05
47 INT304322 Hif1a Positive_regulation of Positive_regulation of VEGFA 1 0.11 0.39 0.05
48 INT249921 Binding of Hif1a and Asph 1 0.05 0.41 0.04
49 INT102247 Binding of EPO and HIF1A 1 0.41 0.65 0.04
50 INT173060 Negative_regulation of VHLL Positive_regulation of Positive_regulation of HIF1A 1 0.04 0.66 0.04
51 INT340394 Binding of Bax and Bbc3 1 0.01 0.36 0.04
52 INT297159 Gsta3 Negative_regulation of Hif1a 1 0.00 0.54 0.03
53 INT322471 Hif1a Positive_regulation of VEGFA 1 0.05 0.26 0.03
54 INT247576 Binding of Hif1a and Vbp1 1 0.01 0.6 0
55 INT189554 Binding of HIF1A and Positive_regulation of EGLN1 1 0.04 0.86 0
56 INT135174 Myst2 Positive_regulation of Binding of Hif1a 1 0.41 0 0
57 INT143438 HIF1A Regulation of Gene_expression of VEGFA 1 0.69 0.13 0
58 INT315543 NARFL Regulation of Gene_expression of HIF1A 1 0.01 0.63 0
59 INT229825 Fos Positive_regulation of Mt2A 1 0.41 0.71 0
60 INT247574 Ube2e3 Positive_regulation of Hif1a 1 0.04 0.62 0
61 INT345485 Binding of MCL1 and BBC3 1 0.01 0.79 0
62 INT177786 TFAM Regulation of Gene_expression of MT1F 1 0.00 0.17 0
63 INT315069 ITGB4 Regulation of MT1X 1 0.27 0.52 0
64 INT241307 Positive_regulation of HIF1A Positive_regulation of Positive_regulation of EPO 1 0.12 0.64 0
65 INT315049 IGF1R Regulation of MT1X 1 0.29 0.52 0
66 INT247575 Binding of Epo and Hif1a 1 0.09 1.24 0
67 INT290478 Mitf Positive_regulation of HIF1A 1 0.57 0.61 0
68 INT135175 Myst2 Positive_regulation of Hif1a 1 0.41 0 0
69 INT229827 Fos Positive_regulation of Mt1a 1 0.40 0.36 0
70 INT189552 EGLN1 Positive_regulation of HIF1A 1 0.05 0.98 0
71 INT188968 Binding of MT1F and Alb 1 0.00 0.45 0
72 INT260496 Hif1a Regulation of Gene_expression of VEGFA 1 0.12 0.93 0
73 INT177785 Negative_regulation of MTF1 Negative_regulation of MT1F 1 0.03 0.16 0
74 INT249924 Cpox Positive_regulation of Hif1a 1 0.01 0.68 0
75 INT212864 MT1A Positive_regulation of PPRC1 1 0.20 0 0
76 INT337352 Binding of ARNT and HIF1A 1 0.14 0.61 0
77 INT180861 TGFB1 Positive_regulation of MT1E 1 0.17 1.22 0
78 INT119045 HIF1A Regulation of Regulation of TP53 1 0.09 1.06 0
79 INT262710 Binding of Crem and Hif1a 1 0.00 1.85 0
80 INT119046 HIF1A Regulation of TP53 1 0.05 1.06 0
81 INT322470 Binding of Bcl6 and Hif1a 1 0.06 0.52 0
82 INT143439 Positive_regulation of HIF1A Regulation of Gene_expression of VEGFA 1 0.30 0.13 0
83 INT282998 Binding of Bcl2 and Bbc3 1 0.00 0.43 0
84 INT290479 Binding of HIF1A and Mitf 1 0.30 1.29 0
85 INT119044 HIF1A Regulation of TCEAL1 1 0.02 1.06 0
86 INT313884 XRCC1 Positive_regulation of Localization of HIF1A 1 0.00 0.65 0
87 INT119047 HIF1A Regulation of Regulation of TCEAL1 1 0.08 1.06 0
88 INT345487 HIF1A Positive_regulation of PMAIP1 1 0.27 1.23 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of growth. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of growth. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT105387 Gene_expression of HIF1A 116 0.77 98.62 14.66
2 INT100379 Positive_regulation of HIF1A 69 0.69 57.31 10.4
3 INT27916 Gene_expression of Mt1a 6 0.47 4.4 7.04
4 INT35780 Positive_regulation of Mt1a 9 0.55 4.9 6.08
5 INT135170 Positive_regulation of Hif1a 86 0.67 99.4 6.07
6 INT112713 Gene_expression of Hif1a 24 0.75 20.48 5.45
7 INT135172 Gene_expression of Hif1a 56 0.76 46.49 5.44
8 INT104760 Localization of MT1A 13 0.44 1.5 4.85
9 INT112704 Positive_regulation of Hif1a 25 0.67 21.49 4.23
10 INT28390 Negative_regulation of Mt1a 4 0.36 1.13 3.39
11 INT111369 Transcription of Mt1a 4 0.68 1.01 3.35
12 INT20006 Gene_expression of MT1F 27 0.68 19.55 3.18
13 INT112365 Regulation of HIF1A 27 0.60 21.24 3.05
14 INT105390 Positive_regulation of Gene_expression of HIF1A 27 0.49 26.3 2.88
15 INT134756 Positive_regulation of Gene_expression of Hif1a 8 0.50 11.14 2.68
16 INT111368 Transcription of Mt2A 1 0.69 0.94 2.66
17 INT100381 Positive_regulation of Positive_regulation of HIF1A 12 0.49 12.05 2.17
18 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13
19 INT104759 Positive_regulation of MT1A 3 0.26 0.28 1.84
20 INT104761 Positive_regulation of Localization of MT1A 1 0.38 0.23 1.84
21 INT326006 Regulation of Gene_expression of Mt1a 1 0.07 0.55 1.79
22 INT94534 Gene_expression of MT2A 8 0.75 11.28 1.76
23 INT94524 Gene_expression of MT1A 6 0.39 1.66 1.75
24 INT326007 Negative_regulation of Gene_expression of Mt1a 1 0.07 1.32 1.68
25 INT122597 Transcription of Hif1a 5 0.69 5.56 1.63
26 INT153723 Negative_regulation of Gene_expression of Hif1a 2 0.41 1.25 1.58
27 INT135171 Positive_regulation of Gene_expression of Hif1a 15 0.68 16.95 1.51
28 INT119048 Negative_regulation of Gene_expression of HIF1A 10 0.57 9.23 1.5
29 INT111367 Regulation of Transcription of Mt2A 1 0.44 0.65 1.5
30 INT111366 Regulation of Transcription of Mt1a 1 0.43 0.65 1.5
31 INT143443 Localization of HIF1A 14 0.78 10.93 1.49
32 INT9269 Regulation of Mt1a 3 0.36 0 1.43
33 INT232785 Localization of Hif1a 8 0.46 10.37 1.33
34 INT94776 Binding of MT1E 1 0.35 0.15 1.29
35 INT142530 Negative_regulation of Positive_regulation of Mt2A 1 0.43 0.36 1.23
36 INT142531 Positive_regulation of Mt2A 1 0.70 0.36 1.22
37 INT67589 Gene_expression of MT1E 8 0.51 7.52 1.09
38 INT177832 Positive_regulation of Gene_expression of MT1F 5 0.28 2.75 1.05
39 INT102249 Binding of HIF1A 39 0.36 30.47 1.04
40 INT94532 Regulation of MT2A 5 0.36 4.25 0.98
41 INT326005 Positive_regulation of Positive_regulation of Mt1a 1 0.08 0.48 0.97
42 INT326008 Positive_regulation of Negative_regulation of Mt1a 1 0.08 0.48 0.97
43 INT288625 Localization of MT2A 1 0.46 0.46 0.95
44 INT177820 Negative_regulation of Gene_expression of MT1F 4 0.20 1.36 0.92
45 INT44499 Localization of Mt1a 2 0.59 0.12 0.9
46 INT203377 Regulation of MT1E 1 0.17 3.25 0.84
47 INT155352 Phosphorylation of HIF1A 3 0.79 3.34 0.83
48 INT100378 Protein_catabolism of HIF1A 7 0.96 5.05 0.8
49 INT135169 Binding of Hif1a 22 0.47 12.48 0.79
50 INT44501 Regulation of Localization of Mt1a 1 0.30 0 0.75
51 INT169731 Negative_regulation of Localization of HIF1A 1 0.57 0.57 0.73
52 INT100380 Negative_regulation of Positive_regulation of HIF1A 2 0.57 1.6 0.72
53 INT152672 Positive_regulation of Gene_expression of MT1A 2 0.29 0.35 0.68
54 INT326004 Binding of Mt1a 1 0.06 0.24 0.68
55 INT142696 Positive_regulation of BBC3 3 0.67 1.7 0.67
56 INT128795 Regulation of Positive_regulation of HIF1A 2 0.61 0.95 0.67
57 INT233837 Negative_regulation of Hif1a 9 0.26 12.72 0.65
58 INT112708 Negative_regulation of Hif1a 5 0.38 2.7 0.64
59 INT100382 Positive_regulation of Protein_catabolism of HIF1A 2 0.45 1.75 0.64
60 INT100377 Negative_regulation of Protein_catabolism of HIF1A 1 0.57 0.9 0.63
61 INT136465 Regulation of Hif1a 5 0.39 7.05 0.62
62 INT112363 Regulation of Gene_expression of HIF1A 6 0.60 2.28 0.61
63 INT155353 Positive_regulation of Phosphorylation of HIF1A 1 0.49 2.58 0.61
64 INT275637 Positive_regulation of Gene_expression of MT2A 2 0.28 2.49 0.6
65 INT135173 Regulation of Gene_expression of Hif1a 3 0.44 2.49 0.53
66 INT134758 Positive_regulation of Transcription of Hif1a 2 0.33 2.44 0.53
67 INT203382 Regulation of MT1X 1 0.17 2.26 0.52
68 INT153065 Regulation of Hif1a 8 0.28 8.57 0.51
69 INT177823 Negative_regulation of MT1F 1 0.08 0.34 0.48
70 INT153067 Positive_regulation of Positive_regulation of Hif1a 10 0.49 11.83 0.47
71 INT156734 Gene_expression of BBC3 3 0.58 2.41 0.46
72 INT20007 Regulation of Gene_expression of MT1F 4 0.07 2.35 0.43
73 INT253337 Localization of MT1E 4 0.59 8.89 0.41
74 INT247549 Transcription of Hif1a 7 0.42 8.77 0.36
75 INT94543 Binding of MT2A 5 0.29 0.96 0.36
76 INT320784 Protein_catabolism of Hif1a 3 0.61 2.41 0.34
77 INT247563 Negative_regulation of Positive_regulation of Hif1a 1 0.16 9.12 0.32
78 INT94540 Gene_expression of MT1X 6 0.49 5.51 0.28
79 INT173105 Transcription of HIF1A 6 0.67 4.47 0.28
80 INT232786 Positive_regulation of Localization of Hif1a 2 0.31 2.63 0.27
81 INT228124 Positive_regulation of Bbc3 3 0.49 2.29 0.24
82 INT297982 Negative_regulation of ING5 1 0.33 1.29 0.24
83 INT159113 Binding of MT1F 5 0.42 1.85 0.23
84 INT159112 Transcription of MT1F 2 0.60 0.71 0.23
85 INT288627 Positive_regulation of MT2A 1 0.33 0.3 0.23
86 INT173103 Positive_regulation of Transcription of HIF1A 3 0.49 2.11 0.21
87 INT197363 Regulation of MT1F 1 0.08 1.14 0.21
88 INT282970 Gene_expression of Bbc3 2 0.02 2.83 0.2
89 INT247564 Positive_regulation of Transcription of Hif1a 1 0.19 2.05 0.2
90 INT334204 Localization of MT1F 1 0.10 0.69 0.2
91 INT189390 Positive_regulation of MT1F 5 0.08 0.85 0.14
92 INT249919 Regulation of Regulation of Hif1a 2 0.29 1.81 0.14
93 INT249908 Binding of Hif1a 2 0.31 1.48 0.14
94 INT94533 Positive_regulation of MT1X 1 0.44 1.78 0.14
95 INT282973 Binding of Bbc3 2 0.01 2.87 0.13
96 INT249913 Regulation of Gene_expression of Hif1a 2 0.32 1.82 0.13
97 INT103508 Binding of Mt2A 1 0.47 1.24 0.12
98 INT180883 Positive_regulation of MT1E 7 0.27 4.63 0.11
99 INT105392 Positive_regulation of Binding of HIF1A 5 0.45 3.83 0.1
100 INT153064 Positive_regulation of Regulation of Hif1a 1 0.45 1.52 0.1
101 INT260478 Negative_regulation of Positive_regulation of Hif1a 2 0.30 1.23 0.09
102 INT260462 Negative_regulation of Binding of Hif1a 1 0.30 1.13 0.09
103 INT260451 Positive_regulation of Positive_regulation of Hif1a 1 0.36 1.01 0.08
104 INT340388 Negative_regulation of Gene_expression of Bbc3 1 0.01 0.73 0.08
105 INT94531 Transcription of MT2A 2 0.56 1.52 0.07
106 INT94535 Negative_regulation of Gene_expression of MT2A 1 0.34 1.7 0.07
107 INT297157 Negative_regulation of Negative_regulation of Hif1a 1 0.03 0.54 0.07
108 INT247560 Negative_regulation of Negative_regulation of Hif1a 1 0.16 2.06 0.07
109 INT94525 Transcription of MT1X 1 0.43 1.08 0.07
110 INT143444 Positive_regulation of Localization of HIF1A 3 0.45 1.26 0.06
111 INT247553 Regulation of Negative_regulation of Hif1a 1 0.17 1.36 0.06
112 INT297158 Regulation of Localization of Hif1a 1 0.03 0.32 0.06
113 INT94541 Positive_regulation of Gene_expression of MT1X 1 0.44 1.84 0.06
114 INT247559 Regulation of Positive_regulation of Hif1a 2 0.23 1.64 0.05
115 INT247555 Positive_regulation of Binding of Hif1a 2 0.31 1.15 0.05
116 INT265479 Positive_regulation of Localization of BBC3 1 0.49 1.18 0.05
117 INT265489 Localization of BBC3 1 0.73 1.17 0.05
118 INT297156 Localization of Hif1a 1 0.06 0.32 0.05
119 INT322464 Regulation of Localization of Hif1a 1 0.28 0.59 0.05
120 INT155174 Regulation of Regulation of HIF1A 3 0.24 1.57 0.04
121 INT173079 Positive_regulation of Regulation of HIF1A 1 0.26 0.64 0.04
122 INT249918 Regulation of Protein_catabolism of Hif1a 1 0.29 0.4 0.04
123 INT249916 Protein_catabolism of Hif1a 1 0.64 0.39 0.04
124 INT105389 Negative_regulation of Binding of HIF1A 4 0.42 3.2 0.03
125 INT189607 Regulation of Binding of HIF1A 2 0.06 1.49 0
126 INT296123 Negative_regulation of Transcription of MT2A 1 0.13 0.44 0
127 INT212867 Regulation of MT1A 1 0.23 0 0
128 INT188646 Binding of MT1A 1 0.05 0.62 0
129 INT189594 Negative_regulation of Transcription of HIF1A 1 0.05 0.94 0
130 INT249915 Regulation of Positive_regulation of Hif1a 1 0.29 0.85 0
131 INT112706 Negative_regulation of Gene_expression of Hif1a 1 0.08 0 0
132 INT322450 Negative_regulation of Binding of Hif1a 1 0.26 0.32 0
133 INT296125 Regulation of Gene_expression of MT2A 1 0.14 0.49 0
134 INT254679 Negative_regulation of Positive_regulation of Bbc3 1 0.00 0.72 0
135 INT189606 Regulation of Transcription of HIF1A 1 0.06 0.46 0
136 INT315117 Localization of MT1X 1 0.57 0.26 0
137 INT249917 Regulation of Negative_regulation of Hif1a 1 0.29 0.29 0
138 INT177853 Negative_regulation of Negative_regulation of MT1F 1 0.06 0.16 0
139 INT282980 Negative_regulation of Binding of Bbc3 1 0.01 0.7 0
140 INT296127 Negative_regulation of MT2A 1 0.06 0.43 0
141 INT280587 Negative_regulation of MT1E 1 0.01 2.56 0
142 INT247562 Negative_regulation of Transcription of Hif1a 1 0.16 2.39 0
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