GO:0045944

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Name positive regulation of transcription from RNA polymerase II promoter
Categary Process
Go Slim No
Go Link GO:0045944
Unique Molecular Interactions 21083
Total Molecular Interactions 29107
Total Single Events 242857
Pain Genes Associated 769

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of transcription from RNA polymerase II promoter. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of transcription from RNA polymerase II promoter. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT69872 Binding of MC1R and POMC 52 0.54 8.87 18.3
2 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49
3 INT10268 Binding of PDYN and POMC 11 0.39 0.08 10.36
4 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
5 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46
6 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18
7 INT180785 Gdnf Positive_regulation of Calca 1 0.23 1.96 8.04
8 INT11250 Cck Positive_regulation of Gene_expression of Fos 14 0.78 0.08 7.29
9 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
10 INT188692 Binding of Cd40 and Cd40lg 32 0.34 22.95 6.62
11 INT91538 Pomc Positive_regulation of P9Ehs1 6 0.11 1.47 6.23
12 INT338167 Binding of CDKN2A and MC1R 1 0.42 6.14 5.76
13 INT179502 Binding of Cd14 and Tlr4 29 0.39 13.77 5.73
14 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
15 INT79759 Ngf Regulation of Il6 1 0.60 4.62 5.62
16 INT140935 Binding of Cd40lg and Cd40 1 0.30 6.34 5.61
17 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
18 INT92466 Pomc Positive_regulation of Binding of Crygs 8 0.06 0 5.56
19 INT170447 Binding of Pax3 and Spr 1 0.01 0.1 5.37
20 INT126335 Binding of Pax3 and Tac1 6 0.07 6.22 5.27
21 INT15842 Crh Positive_regulation of Localization of Pomc 15 0.73 5 5.05
22 INT1310 Pomc Regulation of Localization of Prl 9 0.40 0.61 4.96
23 INT211710 Binding of Mc1r and a 7 0.44 0.37 4.78
24 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68
25 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65
26 INT139706 Tnf Positive_regulation of Ltp 1 0.03 2.61 4.63
27 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
28 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
29 INT186566 Hpcl1 Positive_regulation of Fos 1 0.17 0.38 4.49
30 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
31 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
32 INT180774 Gdnf Positive_regulation of Trpv1 1 0.33 2.43 4.37
33 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
34 INT113223 POMC Regulation of MC1R 6 0.68 0.39 4.24
35 INT1313 Pomc Positive_regulation of Prl 7 0.35 0 4.19
36 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
37 INT34220 Binding of POMC and Oprl1 4 0.01 0.25 4.05
38 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01
39 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93
40 INT61359 TNF Positive_regulation of NFKB1 11 0.63 6.66 3.89
41 INT113080 Drd1a Positive_regulation of Phosphorylation of Creb1 2 0.27 0.43 3.88
42 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
43 INT220623 Binding of Stat1 and Bace1 11 0.25 10.33 3.81
44 INT11252 Cck Positive_regulation of Fos 6 0.78 0 3.79
45 INT104977 MITF Regulation of Gene_expression of MC1R 1 0.69 0.91 3.71
46 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 0.47 0.72 3.63
47 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
48 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
49 INT17317 Binding of Jun and Fos 7 0.42 1.03 3.5
50 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35
51 INT7436 CFP Positive_regulation of Binding of POMC 1 0.02 0.18 3.35
52 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22
53 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22
54 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
55 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
56 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16
57 INT17456 Binding of CSF2 and POMC 3 0.32 4.06 3.15
58 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
59 INT6076 Negative_regulation of Pomc Positive_regulation of Penk 3 0.31 0 3.14
60 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
61 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12
62 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
63 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
64 INT81708 POMC Regulation of Gene_expression of ITGAM 1 0.53 0.72 3.1
65 INT101408 Binding of Grin1 and Olr1469 1 0.03 0.86 3.1
66 INT101407 Binding of Grin1 and Spr 1 0.14 0.86 3.09
67 INT309150 Edc4 Positive_regulation of Creb1 1 0.03 3.46 3.09
68 INT122776 Gdnf Positive_regulation of Gene_expression of Trpv1 2 0.67 2.13 3.06
69 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
70 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
71 INT113234 Binding of Pax3 and Tacr1 3 0.12 1.54 2.93
72 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
73 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
74 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9
75 INT156381 Binding of Grin1 and Dlg4 1 0.39 0.86 2.9
76 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
77 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
78 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
79 INT106560 Binding of Ntf3 and Ntrk2 3 0.14 2.47 2.84
80 INT32656 Pomc Positive_regulation of Rbm39 1 0.08 0.42 2.84
81 INT107723 POMC Positive_regulation of MC1R 7 0.68 0.71 2.82
82 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
83 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
84 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
85 INT31513 Crh Regulation of POMC 3 0.29 5.06 2.78
86 INT190167 Binding of JUN and MMP12 1 0.26 0.82 2.76
87 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
88 INT127621 Bst1 Regulation of Positive_regulation of Fos 1 0.26 0 2.73
89 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
90 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
91 INT147107 TGFB1 Positive_regulation of Gene_expression of NGF 1 0.49 0.67 2.69
92 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64
93 INT62450 Il2 Positive_regulation of Localization of Crh 1 0.43 0.59 2.64
94 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
95 INT30345 Pomc Regulation of Localization of Penk 3 0.31 0 2.61
96 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
97 INT121698 HRAS Negative_regulation of Gene_expression of MMP3 1 0.06 0.5 2.6
98 INT29446 Crh Positive_regulation of Localization of POMC 8 0.38 1.87 2.58
99 INT152501 Binding of Tnf and Tnfrsf1a 4 0.31 3 2.58
100 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51
101 INT294909 Pax3 Positive_regulation of Gene_expression of Il6 1 0.09 5.43 2.51
102 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
103 INT299783 Binding of Cd28 and Cd80 7 0.14 6.49 2.49
104 INT317528 Ppp1r9b Regulation of Grin1 1 0.18 0.2 2.48
105 INT21520 Crh Regulation of Pomc 3 0.22 0.4 2.45
106 INT103330 Ngf Positive_regulation of Gdnf 2 0.28 1.27 2.45
107 INT117532 SETBP1 Positive_regulation of Gene_expression of TNF 1 0.54 0.85 2.44
108 INT122775 Gdnf Regulation of Gene_expression of Trpv1 4 0.59 2.72 2.42
109 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41
110 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
111 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39
112 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
113 INT61733 Tlr4 Positive_regulation of Gene_expression of Tnf 3 0.26 1.99 2.36
114 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
115 INT54489 Binding of Jun and Rabep2 4 0.16 1.48 2.3
116 INT314205 Ngf Positive_regulation of Phosphorylation of Mapk14 1 0.43 1.24 2.3
117 INT131257 ITIH4 Positive_regulation of Gene_expression of Nfkbia 1 0.23 1.41 2.3
118 INT139705 Negative_regulation of Tnf Positive_regulation of Ltp 1 0.03 1.19 2.3
119 INT156622 Umod Regulation of Phosphorylation of Creb1 1 0.05 0.33 2.27
120 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
121 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
122 INT51317 Binding of POMC and OR5D2P 1 0.00 0.6 2.23
123 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
124 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
125 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21
126 INT34310 CRH Positive_regulation of POMC 3 0.42 0.62 2.21
127 INT317524 Binding of Camk2a and Grin1 1 0.17 0.06 2.21
128 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
129 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
130 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
131 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
132 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
133 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
134 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
135 INT32586 H2-Ab1 Regulation of Pomc 1 0.03 0.14 2.19
136 INT146520 Tmem132a Regulation of Gene_expression of Fos 1 0.69 0.5 2.18
137 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
138 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
139 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17
140 INT1315 Pomc Positive_regulation of Localization of Gnrhr 3 0.38 0.16 2.16
141 INT49242 Binding of Mc1r and Pomc 10 0.38 3.79 2.15
142 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14
143 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
144 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09
145 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08
146 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
147 INT28387 Pomc Positive_regulation of Localization of LH 2 0.40 0.28 2.07
148 INT331105 Vmn1r71 Negative_regulation of Mc1r 1 0.04 0.64 2.07
149 INT158964 FosB Negative_regulation of Creb1 1 0.21 0 2.07
150 INT114927 Positive_regulation of Binding of Oprm1 and Creb1 1 0.17 0.28 2.07
151 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06
152 INT161190 CRX Regulation of Gene_expression of Ntrk2 1 0.04 3.05 2.06
153 INT114923 Binding of Oprm1 and Creb1 1 0.16 0.28 2.06
154 INT134215 CRH Positive_regulation of ENG 1 0.13 1.22 2.06
155 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05
156 INT115042 Gdnf Regulation of Calca 1 0.53 0.25 2.03
157 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
158 INT88883 IRF6 Positive_regulation of Nfkb1 1 0.11 0.53 2.01
159 INT140032 Tnf Positive_regulation of Gene_expression of Ifng 2 0.43 2.23 2
160 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
161 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
162 INT138962 Dbi Positive_regulation of Pomc 1 0.00 1.53 2
163 INT32585 H2-Ab1 Negative_regulation of Pomc 1 0.03 0.13 2
164 INT124133 Camk2a Regulation of Phosphorylation of Creb1 1 0.46 0 2
165 INT60626 Crh Positive_regulation of Localization of Pomc 7 0.54 2.3 1.99
166 INT26948 Pomc Positive_regulation of Localization of Gh1 2 0.22 0.15 1.99
167 INT213973 Binding of Pax3 and Mthfd1 1 0.00 0.16 1.99
168 INT117794 Hpcl1 Positive_regulation of Gene_expression of Fos 3 0.17 0.15 1.98
169 INT54488 Npepo Regulation of Gene_expression of Jun 1 0.30 0 1.98
170 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
171 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
172 INT110525 Binding of MC1R and OCA2 1 0.41 1.08 1.97
173 INT264953 Binding of POMC and TLR4 1 0.03 0.89 1.96
174 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95
175 INT217042 IRF6 Positive_regulation of TNF 4 0.27 3.03 1.95
176 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
177 INT264947 Binding of POMC and TLR2 1 0.03 0.89 1.95
178 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
179 INT227493 Binding of TCEA1 and SIRT2 1 0.01 1.55 1.93
180 INT125348 Decr1 Regulation of Gene_expression of Fos 1 0.00 0.1 1.92
181 INT102130 Il6 Positive_regulation of Gene_expression of Crp 4 0.05 7.39 1.91
182 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
183 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
184 INT31438 Penk Positive_regulation of Localization of Pomc 1 0.18 0 1.9
185 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
186 INT186432 Prkaca Regulation of Creb1 1 0.14 0.45 1.9
187 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
188 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
189 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
190 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
191 INT314210 Ngf Regulation of Phosphorylation of Mapk14 1 0.34 0.85 1.84
192 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
193 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 0.42 2.39 1.82
194 INT19496 Pomc Regulation of Localization of Ins1 1 0.55 0.33 1.82
195 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 0.48 1.04 1.81
196 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8
197 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8
198 INT112526 D2Mit212 Negative_regulation of Gene_expression of Fos 1 0.03 0.28 1.8
199 INT224432 TNF Positive_regulation of Gene_expression of VEGFA 1 0.13 5.83 1.8
200 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of transcription from RNA polymerase II promoter. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of transcription from RNA polymerase II promoter. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02
2 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82
3 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684
4 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87
5 INT443 Localization of POMC 1020 0.81 284.52 443.17
6 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
7 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16
8 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84
9 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83
10 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98
11 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81
12 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98
13 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54
14 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68
15 INT6852 Localization of TNF 883 0.81 705.95 270.84
16 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78
17 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57
18 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
19 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2
20 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
21 INT738 Regulation of POMC 459 0.62 111.19 243.74
22 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97
23 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66
24 INT1308 Localization of Pomc 457 0.81 66.83 217.5
25 INT6481 Binding of TNF 624 0.48 510.2 214.82
26 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210
27 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24
28 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
29 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58
30 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61
31 INT1652 Regulation of Pomc 387 0.62 61.01 186.51
32 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
33 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77
34 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63
35 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37
36 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61
37 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1
38 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69
39 INT60694 Gene_expression of Il10 567 0.78 369.48 143.69
40 INT9660 Regulation of TNF 363 0.62 312.94 139.99
41 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24
42 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52
43 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132
44 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05
45 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36
46 INT695 Binding of POMC 304 0.48 56.66 126.85
47 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73
48 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64
49 INT7533 Gene_expression of Tlr4 720 0.78 343.22 121.57
50 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28
51 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61
52 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38
53 INT1438 Localization of Pomc 360 0.81 101.26 116.47
54 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12
55 INT118381 Gene_expression of Il17a 405 0.76 306.97 112.06
56 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01
57 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96
58 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
59 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06
60 INT60526 Gene_expression of IL10 449 0.78 292.71 107.84
61 INT12082 Localization of IL6 365 0.81 241.78 105.78
62 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
63 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
64 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
65 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46
66 INT5587 Regulation of Fos 191 0.62 40.81 99.7
67 INT65500 Gene_expression of App 605 0.78 429.94 98.31
68 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31
69 INT56130 Gene_expression of MC1R 259 0.78 62.7 97.55
70 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38
71 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
72 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84
73 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51
74 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14
75 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79
76 INT10166 Localization of Tnf 237 0.81 153.95 88.64
77 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45
78 INT8534 Localization of Pax3 85 0.59 28.71 82.82
79 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98
80 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65
81 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59
82 INT133211 Gene_expression of Runx1 169 0.77 83.4 76.16
83 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
84 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57
85 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
86 INT48244 Gene_expression of Il4 172 0.76 132.38 73.42
87 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99
88 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92
89 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
90 INT10359 Gene_expression of Ifng 159 0.78 79.6 72.14
91 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38
92 INT57380 Phosphorylation of Creb1 213 0.82 66.8 71.26
93 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06
94 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71
95 INT49995 Positive_regulation of Gene_expression of Tnf 187 0.70 125.07 70.54
96 INT79494 Positive_regulation of Gene_expression of VEGFA 577 0.70 442.94 69.73
97 INT6849 Localization of IL1B 229 0.81 112.56 69.63
98 INT14624 Gene_expression of Pax3 100 0.38 33.22 69.47
99 INT7534 Gene_expression of Ifng 193 0.78 111.02 68.6
100 INT9484 Gene_expression of Jun 175 0.78 34.89 68.54
101 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13
102 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85
103 INT19511 Localization of Il6 212 0.81 118.17 67.67
104 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
105 INT462 Regulation of Pomc 157 0.62 41.67 67.27
106 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05
107 INT11807 Gene_expression of Il2 266 0.78 112 64.97
108 INT11937 Localization of Il6 228 0.81 139.83 64.39
109 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
110 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61
111 INT9657 Positive_regulation of Gene_expression of Il6 237 0.70 180.45 63.6
112 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42
113 INT10706 Regulation of Il6 150 0.62 93.23 62.34
114 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07
115 INT1437 Negative_regulation of Pomc 132 0.59 35.22 60.97
116 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
117 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18
118 INT102020 Gene_expression of Creb1 190 0.78 57.31 59.77
119 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
120 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26
121 INT16258 Gene_expression of Ntf3 121 0.78 53.93 59.03
122 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
123 INT1307 Positive_regulation of Localization of Pomc 120 0.70 24.58 58.48
124 INT82055 Positive_regulation of Creb1 176 0.70 60.2 58.39
125 INT6436 Positive_regulation of Positive_regulation of Fos 101 0.70 18.71 57.96
126 INT7340 Regulation of Grin1 87 0.62 30.37 57.93
127 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
128 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06
129 INT6669 Negative_regulation of Positive_regulation of Fos 98 0.59 23.5 56.82
130 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74
131 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72
132 INT21737 Binding of MC1R 129 0.48 45.45 56.54
133 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34
134 INT1463 Binding of Pomc 129 0.48 15.89 56.27
135 INT17458 Negative_regulation of Gene_expression of FOS 98 0.57 36.77 55.69
136 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6
137 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5
138 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47
139 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69
140 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53
141 INT117223 Gene_expression of TLR4 348 0.78 206.18 54.42
142 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
143 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3
144 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
145 INT48642 Positive_regulation of TCEA1 92 0.70 24.59 53.64
146 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32
147 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21
148 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
149 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18
150 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
151 INT122041 Binding of Ppara 308 0.48 189.17 51.48
152 INT12345 Gene_expression of Il2 142 0.78 59.17 51.21
153 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05
154 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
155 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
156 INT9210 Regulation of IL6 166 0.62 125.61 49.95
157 INT6796 Positive_regulation of Jun 165 0.70 37.18 49.64
158 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
159 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16
160 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02
161 INT62426 Gene_expression of Mc1r 127 0.78 42.99 48.01
162 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
163 INT57021 Positive_regulation of Gene_expression of Grin1 62 0.70 24.77 47.31
164 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33
165 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42
166 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33
167 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
168 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53
169 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29
170 INT73502 Positive_regulation of IL10 154 0.69 124.87 43.5
171 INT5307 Regulation of Tnf 87 0.62 78.71 43.4
172 INT60695 Positive_regulation of Gene_expression of Il10 154 0.70 120.28 43.07
173 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9
174 INT1295 Binding of Pomc 85 0.48 12.92 42.8
175 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
176 INT4913 Binding of Pax3 52 0.28 9.57 42.67
177 INT13354 Transcription of TNF 108 0.72 85.81 42.32
178 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
179 INT11939 Negative_regulation of Il6 138 0.59 87.46 41.24
180 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
181 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
182 INT92517 Gene_expression of Grin1 105 0.78 29.53 39.43
183 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97
184 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67
185 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
186 INT48933 Gene_expression of Mapk3 93 0.75 44.39 37.92
187 INT11246 Binding of Grin1 65 0.48 14.53 36.93
188 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81
189 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
190 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
191 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
192 INT133028 Gene_expression of TLR2 209 0.73 131.92 36.17
193 INT101992 Localization of VEGFA 413 0.81 258.23 36.15
194 INT13501 Binding of Drd2 65 0.48 23.76 35.6
195 INT48896 Positive_regulation of Gene_expression of Il10 73 0.70 43.14 35.5
196 INT53577 Negative_regulation of Localization of TNF 110 0.59 59.28 35.23
197 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
198 INT6484 Binding of IL1B 122 0.47 75.84 35.07
199 INT65055 Negative_regulation of Nfkb1 83 0.58 44.85 34.94
200 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76
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