GO:0045947

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Name negative regulation of translational initiation
Categary Process
Go Slim No
Go Link GO:0045947
Unique Molecular Interactions 107
Total Molecular Interactions 172
Total Single Events 1017
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of translational initiation. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of translational initiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT341218 Binding of Eif4e and Eif4ebp1 1 0.19 2.65 1.23
2 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
3 INT151545 Adcy1 Positive_regulation of Regulation of Fmr1 1 0.48 0.37 0.37
4 INT151544 Camk4 Positive_regulation of Regulation of Fmr1 1 0.50 0.36 0.37
5 INT44983 Ltc4s Positive_regulation of Rara 1 0.01 0.15 0.33
6 INT44985 KNG1 Positive_regulation of Rara 1 0.00 0.15 0.32
7 INT341214 Tas2r130 Positive_regulation of Phosphorylation of Eif4ebp1 1 0.00 0.68 0.31
8 INT211997 CORD1 Positive_regulation of Rara 1 0.01 0.68 0.29
9 INT108842 RARA Positive_regulation of Gene_expression of GDF15 1 0.52 0.68 0.23
10 INT349647 Eif2ak1 Positive_regulation of Positive_regulation of Hmox1 1 0.00 1.07 0.2
11 INT349646 Eif2ak1 Regulation of Gene_expression of Hmox1 1 0.00 0.78 0.2
12 INT313023 Binding of Rara and Rxra 1 0.06 0.73 0.17
13 INT204478 Fmr1 Regulation of Gene_expression of App 1 0.50 1.44 0.16
14 INT273902 Mtor Positive_regulation of Eif4ebp1 1 0.50 0.56 0.15
15 INT204497 Fmr1 Regulation of Positive_regulation of Gria1 1 0.04 1.75 0.14
16 INT192106 Regulation of Binding of Rara and Retsat 1 0.00 0.83 0.13
17 INT204489 Fmr1 Regulation of App 1 0.50 1.71 0.13
18 INT192105 Binding of Rara and Retsat 1 0.00 0.83 0.13
19 INT192104 Binding of Rara and Rxrg 1 0.00 0.82 0.1
20 INT341235 Negative_regulation of INS Positive_regulation of Phosphorylation of Eif4ebp1 1 0.01 0.24 0.09
21 INT337072 Binding of Fmr1 and Gusb 1 0.19 1.55 0.08
22 INT204487 Positive_regulation of Fmr1 Regulation of Gene_expression of App 1 0.30 0.8 0.08
23 INT201380 RARA Positive_regulation of Regulation of CPOX 1 0.07 0.21 0.08
24 INT341220 Eif4e Positive_regulation of Eif4ebp1 1 0.20 0.42 0.06
25 INT341219 Binding of Eif4ebp1 and Eif4g3 1 0.05 0 0.06
26 INT197727 Binding of RARA and Positive_regulation of PPARA 1 0.02 0.96 0.05
27 INT349645 Eif2ak1 Positive_regulation of Hmox1 1 0.00 0.18 0.05
28 INT257869 Rps6kb1 Regulation of Eif4ebp1 1 0.02 0.64 0.04
29 INT287613 Binding of Fmr1 and Cysltr1 1 0.01 0.18 0.04
30 INT341231 INS Positive_regulation of Phosphorylation of Eif4ebp1 1 0.01 0.13 0.04
31 INT257872 Eif4ebp1 Regulation of Rps6kb1 1 0.02 0.64 0.04
32 INT349648 Eif2ak1 Positive_regulation of Gene_expression of Hmox1 1 0.00 0.17 0.04
33 INT341236 ROS1 Positive_regulation of Phosphorylation of Eif4ebp1 1 0.02 0.25 0.04
34 INT291714 Binding of RARA and Rxra 3 0.07 0.2 0.03
35 INT253374 Lep Positive_regulation of Phosphorylation of Eif4ebp1 1 0.04 0.16 0.03
36 INT341225 Negative_regulation of Binding of Eif4e and Eif4ebp1 1 0.17 0.14 0.03
37 INT253416 ATIC Negative_regulation of Phosphorylation of Eif4ebp1 1 0.00 0 0.03
38 INT253411 ATIC Negative_regulation of Eif4ebp1 1 0.00 0 0.03
39 INT182924 Binding of RARA and NR1H4 3 0.02 1.9 0
40 INT182918 Binding of DR1 and RARA 2 0.08 0 0
41 INT182949 Binding of RARA and VDR 1 0.20 0 0
42 INT287620 Fmr1 Regulation of Gene_expression of Fxr2 1 0.43 0 0
43 INT287609 Fmr1 Regulation of Protein_catabolism of Dlg4 1 0.05 0.06 0
44 INT204479 Fmr1 Negative_regulation of Mtap1b 1 0.23 0.68 0
45 INT150051 Mtor Positive_regulation of Eif4ebp1 1 0.50 0.46 0
46 INT204485 Binding of Cish and Fmr1 1 0.01 0 0
47 INT204503 Binding of Fmr1 and RNPC3 1 0.01 0 0
48 INT204495 Fmr1 Negative_regulation of Transcription of Mtap1b 1 0.22 0.68 0
49 INT204499 App Regulation of Fmr1 1 0.50 0.59 0
50 INT204492 Negative_regulation of Binding of App and Fmr1 1 0.42 0.28 0
51 INT204480 Fmr1 Negative_regulation of Positive_regulation of Scn10a 1 0.17 0.74 0
52 INT287612 Binding of Fmr1 and Dnajc13 1 0.01 0.84 0
53 INT341240 Binding of EIF4E and Eif4ebp1 1 0.04 0.5 0
54 INT182919 TGFBI Regulation of RARA 1 0.29 0.08 0
55 INT351097 RRAD Negative_regulation of EIF4EBP1 1 0.00 0 0
56 INT342366 Binding of Rara and OSBPL1A 1 0.16 0 0
57 INT182961 Binding of RARA and KCNIP3 1 0.21 0.76 0
58 INT341221 Eif4e Regulation of Binding of Eif4ebp1 1 0.18 0 0
59 INT341227 Mtor Regulation of Phosphorylation of Eif4ebp1 1 0.02 0.19 0
60 INT287605 Binding of Fmr1 and Kdm5d 1 0.01 0 0
61 INT204474 Fmr1 Negative_regulation of Transcription of Map1b 1 0.41 0.68 0
62 INT287610 Binding of Fmr1 and Fxr1 1 0.46 0 0
63 INT287616 Ap3b1 Regulation of Binding of Fmr1 1 0.01 0 0
64 INT287611 Fmr1 Regulation of Gene_expression of Fxr1 1 0.38 0 0
65 INT351100 RRAD Regulation of EIF4EBP1 1 0.00 0 0
66 INT291682 Positive_regulation of Binding of RARA and TNFRSF10B 1 0.03 0 0
67 INT204490 Binding of Fmr1 and Scn10a 1 0.15 0 0
68 INT204482 Fmr1 Negative_regulation of App 1 0.42 0.74 0
69 INT341216 Regulation of Binding of Eif4e and Eif4ebp1 1 0.11 0 0
70 INT291683 Binding of RARA and TNFRSF10B 1 0.03 0 0
71 INT253360 Lep Positive_regulation of Eif4ebp1 1 0.01 0.08 0
72 INT204488 Binding of Fmr1 and Ncl 1 0.12 0.61 0
73 INT204486 Fmr1 Negative_regulation of Scn10a 1 0.17 0.74 0
74 INT234440 Binding of PROC and RARA 1 0.00 0.73 0
75 INT150049 Ins1 Positive_regulation of Eif4ebp1 1 0.24 0.46 0
76 INT204484 Binding of Fmr1 and Iqcg 1 0.01 0.21 0
77 INT342362 Binding of Irs1 and Rara 1 0.15 0 0
78 INT341233 Positive_regulation of Binding of EIF4E and Eif4ebp1 1 0.06 0.5 0
79 INT287619 Fmr1 Regulation of Dlg4 1 0.12 0.06 0
80 INT225504 Binding of gr and Rara 1 0.02 0 0
81 INT204475 Fmr1 Negative_regulation of Map1b 1 0.41 0.68 0
82 INT182948 KCNIP3 Regulation of Transcription of RARA 1 0.23 0.55 0
83 INT204498 Binding of Fmr1 and 7G1 1 0.39 0.15 0
84 INT291681 Positive_regulation of Binding of DR1 and RARA 1 0.06 0 0
85 INT287608 Binding of Fmr1 and Fxr2 1 0.52 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of translational initiation. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of translational initiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9750 Positive_regulation of Rara 39 0.66 12.44 15.83
2 INT11652 Gene_expression of Rara 30 0.58 24.96 6.98
3 INT228659 Phosphorylation of Eif4ebp1 10 0.80 27.53 6.87
4 INT10374 Gene_expression of RARA 39 0.75 22.59 4.28
5 INT90890 Positive_regulation of RARA 25 0.67 9.32 4.2
6 INT77226 Phosphorylation of Eif4ebp1 36 0.09 6.39 2.91
7 INT151538 Positive_regulation of Fmr1 21 0.68 12.24 2.07
8 INT192092 Positive_regulation of Gene_expression of Rara 8 0.32 4.41 1.68
9 INT116022 Positive_regulation of Positive_regulation of RARA 3 0.11 0.94 1.68
10 INT77227 Positive_regulation of Phosphorylation of Eif4ebp1 11 0.05 2.44 1.67
11 INT151543 Binding of Fmr1 56 0.48 19.4 1.65
12 INT67457 Binding of Rara 12 0.24 8.28 1.45
13 INT151540 Regulation of Fmr1 8 0.59 6.08 1.34
14 INT81400 Binding of RARA 25 0.36 12.93 1.27
15 INT151542 Positive_regulation of Positive_regulation of Fmr1 4 0.58 2.17 1.2
16 INT228661 Negative_regulation of Phosphorylation of Eif4ebp1 6 0.41 2.25 1.16
17 INT182985 Transcription of RARA 9 0.60 3.52 1.12
18 INT77224 Negative_regulation of Phosphorylation of Eif4ebp1 7 0.05 0.7 1.04
19 INT69758 Negative_regulation of Positive_regulation of Rara 2 0.32 0.24 0.97
20 INT192090 Localization of Rara 6 0.46 4.15 0.89
21 INT48251 Regulation of Positive_regulation of Rara 2 0.33 0 0.88
22 INT151539 Negative_regulation of Fmr1 9 0.59 11.85 0.87
23 INT120366 Negative_regulation of Rara 2 0.35 0.15 0.86
24 INT341181 Positive_regulation of Phosphorylation of Eif4ebp1 1 0.30 4.99 0.86
25 INT48250 Regulation of Rara 3 0.29 2.47 0.83
26 INT48249 Positive_regulation of Positive_regulation of Rara 2 0.26 0 0.83
27 INT212109 Localization of RARA 5 0.65 3.17 0.79
28 INT204463 Gene_expression of Fmr1 50 0.78 23.73 0.78
29 INT341172 Regulation of Eif4ebp1 1 0.20 4.42 0.74
30 INT246552 Transcription of Fmr1 11 0.72 6.72 0.71
31 INT77223 Regulation of Eif4ebp1 6 0.03 1.32 0.7
32 INT91398 Regulation of RARA 7 0.59 5.84 0.67
33 INT234472 Positive_regulation of Transcription of RARA 2 0.44 0.13 0.58
34 INT201392 Negative_regulation of RARA 8 0.30 2.99 0.5
35 INT341203 Binding of Eif4ebp1 1 0.21 0.86 0.46
36 INT182966 Regulation of Gene_expression of RARA 2 0.39 0.12 0.42
37 INT77225 Binding of Eif4ebp1 1 0.00 0.07 0.42
38 INT211982 Negative_regulation of Binding of Rara 1 0.28 0.24 0.42
39 INT308847 Regulation of Phosphorylation of Eif4ebp1 3 0.27 2.11 0.41
40 INT151536 Regulation of Regulation of Fmr1 1 0.43 0.53 0.33
41 INT228660 Negative_regulation of Eif4ebp1 2 0.41 1.19 0.32
42 INT246186 Phosphorylation of EIF4EBP1 5 0.46 0.42 0.27
43 INT87042 Regulation of Phosphorylation of Eif4ebp1 1 0.00 0.26 0.27
44 INT228662 Gene_expression of Eif4ebp1 2 0.65 0.91 0.26
45 INT10375 Negative_regulation of Gene_expression of RARA 1 0.57 0.97 0.22
46 INT204468 Negative_regulation of Gene_expression of Fmr1 5 0.59 7.5 0.19
47 INT341187 Regulation of Binding of Eif4ebp1 1 0.12 0.19 0.17
48 INT287577 Positive_regulation of Transcription of Fmr1 2 0.48 2.5 0.16
49 INT192091 Regulation of Localization of Rara 1 0.04 0.67 0.13
50 INT253386 Gene_expression of Eif4ebp1 5 0.07 1.37 0.11
51 INT341199 Negative_regulation of Gene_expression of Eif4ebp1 1 0.19 0.18 0.09
52 INT341193 Positive_regulation of Gene_expression of Eif4ebp1 1 0.22 0.17 0.09
53 INT204442 Regulation of Gene_expression of Fmr1 2 0.44 0.3 0.08
54 INT204466 Negative_regulation of Regulation of Fmr1 2 0.43 0.97 0.08
55 INT44884 Phosphorylation of Eif2ak1 1 0.06 0.17 0.08
56 INT214071 Negative_regulation of Transcription of RARA 3 0.37 1.77 0.07
57 INT87043 Positive_regulation of Eif4ebp1 3 0.06 0.26 0.07
58 INT182975 Phosphorylation of RARA 2 0.58 0.23 0.07
59 INT204458 Regulation of Positive_regulation of Fmr1 1 0.44 0.8 0.07
60 INT341171 Positive_regulation of Eif4ebp1 1 0.22 0.48 0.07
61 INT204457 Regulation of Binding of Fmr1 2 0.45 0.4 0.06
62 INT341196 Positive_regulation of Localization of Eif4ebp1 1 0.30 0.26 0.05
63 INT287587 Regulation of Negative_regulation of Fmr1 1 0.45 0.46 0.05
64 INT204460 Positive_regulation of Gene_expression of Fmr1 7 0.61 6.19 0.03
65 INT253396 Negative_regulation of Eif4ebp1 3 0.05 0 0.03
66 INT281602 Negative_regulation of Localization of Eif4ebp1 1 0.05 0 0.03
67 INT87041 Regulation of Positive_regulation of Eif4ebp1 1 0.01 0.26 0.03
68 INT341207 Localization of Eif4ebp1 1 0.35 0.13 0.03
69 INT281606 Localization of Eif4ebp1 1 0.09 0 0.03
70 INT341201 Negative_regulation of Binding of Eif4ebp1 1 0.19 0.23 0.03
71 INT349650 Negative_regulation of Eif2ak1 1 0.00 0.59 0.03
72 INT182990 Positive_regulation of Gene_expression of RARA 5 0.40 3.45 0
73 INT204446 Localization of Fmr1 5 0.79 1.12 0
74 INT204467 Negative_regulation of Binding of Fmr1 3 0.57 1.43 0
75 INT246178 Gene_expression of EIF4EBP1 3 0.61 1.82 0
76 INT246198 Binding of EIF4EBP1 2 0.36 0.27 0
77 INT351126 Positive_regulation of EIF4EBP1 1 0.45 0.22 0
78 INT246203 Positive_regulation of Binding of EIF4EBP1 1 0.03 0 0
79 INT182965 Positive_regulation of Phosphorylation of RARA 1 0.29 0 0
80 INT287567 Negative_regulation of Negative_regulation of Fmr1 1 0.43 0.14 0
81 INT339011 Negative_regulation of Positive_regulation of Fmr1 1 0.43 2.18 0
82 INT335229 Regulation of Transcription of RARA 1 0.15 0.95 0
83 INT253399 Negative_regulation of Gene_expression of Eif4ebp1 1 0.03 0 0
84 INT183002 Positive_regulation of Binding of RARA 1 0.29 1.08 0
85 INT335226 Negative_regulation of Negative_regulation of RARA 1 0.24 0.71 0
86 INT246188 Positive_regulation of Localization of EIF4EBP1 1 0.03 0 0
87 INT246179 Positive_regulation of Phosphorylation of EIF4EBP1 1 0.03 0.08 0
88 INT287592 Positive_regulation of Regulation of Fmr1 1 0.50 0.61 0
89 INT246171 Regulation of Phosphorylation of EIF4EBP1 1 0.04 0 0
90 INT246200 Localization of EIF4EBP1 1 0.04 0 0
91 INT287579 Positive_regulation of Binding of Fmr1 1 0.50 0 0
92 INT351122 Negative_regulation of Phosphorylation of EIF4EBP1 1 0.05 0.16 0
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