GO:0045955

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Name negative regulation of calcium ion-dependent exocytosis
Categary Process
Go Slim No
Go Link GO:0045955
Unique Molecular Interactions 146
Total Molecular Interactions 230
Total Single Events 1261
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of calcium ion-dependent exocytosis. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of calcium ion-dependent exocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
2 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
3 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
4 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
5 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
6 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
7 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
8 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16
9 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
10 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
11 INT200307 Rest Negative_regulation of Rorb 1 0.00 0.1 1.03
12 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
13 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
14 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
15 INT200308 Binding of Rest and Rorb 1 0.00 0 0.87
16 INT43796 Binding of CDS1 and Adra2a 1 0.06 0 0.86
17 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79
18 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
19 INT84283 Binding of Adra2a and Htr1f 1 0.16 0.15 0.74
20 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
21 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
22 INT132152 Adra2a Regulation of Localization of Abat 1 0.03 0 0.66
23 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
24 INT200317 Rest Negative_regulation of Transcription of Oprm1 1 0.31 0 0.64
25 INT17187 Binding of Adra2a and Fabp6 1 0.16 0.69 0.61
26 INT17186 Positive_regulation of Binding of Adra2a and Fabp6 1 0.21 0.69 0.61
27 INT41250 Binding of Adra2a and Eef1a1 1 0.06 0.4 0.56
28 INT200321 Binding of Rest and Negative_regulation of Gene_expression of Oprm1 1 0.36 0.05 0.49
29 INT7851 Man2a2 Positive_regulation of Adra2a 1 0.13 0 0.49
30 INT165078 Binding of CTSB and Notch1 1 0.00 1.08 0.48
31 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
32 INT26448 Adra2a Regulation of Positive_regulation of Npy 1 0.06 0 0.46
33 INT148377 PDP1 Positive_regulation of NOTCH1 1 0.44 0.64 0.44
34 INT148378 CP Positive_regulation of NOTCH1 1 0.11 0.64 0.44
35 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
36 INT56576 Adra2a Positive_regulation of Localization of Gnrh1 1 0.44 0 0.43
37 INT55395 Binding of Htr1a and Adra2a 1 0.42 0 0.43
38 INT200327 Oprm1 Negative_regulation of Gene_expression of Rest 1 0.31 0 0.41
39 INT34987 Adra2a Positive_regulation of Localization of Gnrhr 1 0.43 0 0.4
40 INT200314 Oprm1 Regulation of Rest 1 0.20 0.1 0.39
41 INT200353 Rest Negative_regulation of Oprm1 1 0.31 0.1 0.39
42 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
43 INT200302 Rest Regulation of Rorb 1 0.00 0.07 0.38
44 INT70656 Adra2a Regulation of Gene_expression of Npy 1 0.23 0 0.38
45 INT200333 Binding of Rest and Sp1 1 0.24 0.07 0.35
46 INT200316 Sp1 Regulation of Gene_expression of Rest 1 0.31 0 0.35
47 INT200352 Binding of Rest and Rcor2 1 0.16 0.44 0.34
48 INT67030 Negative_regulation of Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
49 INT67028 Adra2a Negative_regulation of Nts 1 0.06 0.64 0.33
50 INT67029 Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
51 INT31182 Adra2a Regulation of Localization of Gh 1 0.01 0.35 0.32
52 INT200351 Sp1 Positive_regulation of Gene_expression of Rest 1 0.34 0.07 0.3
53 INT95061 Binding of Adra2a and ADHD1 1 0.02 0.8 0.27
54 INT42635 Adra2a Positive_regulation of epi 1 0.00 0 0.26
55 INT200309 Positive_regulation of Binding of Rest and Sp3 1 0.41 0.88 0.24
56 INT55641 Binding of CHRM1 and Adra2a 1 0.00 0 0.24
57 INT97691 Binding of REST and HDAC9 1 0.26 0.09 0.23
58 INT32735 ADRA2A Regulation of RTCA 1 0.07 0 0.22
59 INT97694 Ngf Negative_regulation of Gene_expression of REST 1 0.01 0.09 0.21
60 INT297544 Pou3f3 Regulation of Notch1 1 0.06 0.41 0.2
61 INT104797 Smarce1 Positive_regulation of REST 1 0.01 0.24 0.15
62 INT316052 Notch1 Regulation of Binding of Cd8a 1 0.01 0.86 0.15
63 INT293712 Binding of Adra2a and Atl1 1 0.06 0.83 0.15
64 INT316053 Notch1 Regulation of Binding of Cd4 1 0.02 0.86 0.15
65 INT118127 Binding of STXBP3 and Stx4 1 0.01 0.24 0.15
66 INT316050 Binding of Notch1 and Regulation of Binding of Cd8a 1 0.01 0.86 0.15
67 INT316051 Binding of Notch1 and Regulation of Binding of Cd4 1 0.02 0.86 0.15
68 INT118126 Binding of STXBP3 and Snap23 1 0.18 0.24 0.15
69 INT103425 Binding of Adra2a and Cyth2 1 0.00 0 0.14
70 INT109082 Adra2a Regulation of Nppa 1 0.21 0.56 0.14
71 INT200338 Rest Positive_regulation of Gene_expression of Oprm1 1 0.36 0 0.13
72 INT153637 Gene_expression of REST Positive_regulation of Gene_expression of Oprm1 1 0.03 0.08 0.1
73 INT297546 Neurod1 Regulation of Notch1 1 0.05 0.2 0.1
74 INT17394 Adra2a Positive_regulation of GNAI1 1 0.02 0.37 0.1
75 INT153636 Binding of REST and Oprm1 1 0.02 0.09 0.09
76 INT278217 Binding of Ciita and Notch1 1 0.41 0.22 0.09
77 INT234222 PSEN1 Regulation of Gene_expression of NOTCH1 1 0.03 0 0.08
78 INT66171 Negative_regulation of Adra2a Negative_regulation of Positive_regulation of Pnmt 1 0.38 0 0.08
79 INT196213 REST Regulation of Gene_expression of CACNA1A 1 0.46 0.08 0.08
80 INT66166 Negative_regulation of Binding of Pnmt and Adra2a 1 0.38 0 0.07
81 INT297246 Binding of Notch1 and Ncstn 1 0.04 0.32 0.07
82 INT327871 Binding of Notch1 and Postn 1 0.38 1.42 0.07
83 INT297244 Regulation of Binding of Notch1 and Ncstn 1 0.05 0.32 0.07
84 INT66167 Negative_regulation of Pnmt Negative_regulation of Adra2a 1 0.38 0 0.07
85 INT66172 Binding of Pnmt and Adra2a 1 0.33 0 0.07
86 INT189557 Binding of NOTCH1 and ROBO4 1 0.01 0.22 0.06
87 INT349314 Binding of Notch1 and Notch3 1 0.11 0.67 0.04
88 INT347165 Binding of NOTCH1 and PAX5 1 0.05 0.86 0.03
89 INT327876 Postn Regulation of Gene_expression of Notch1 1 0.56 0.92 0.03
90 INT347163 NOTCH1 Positive_regulation of MSC 1 0.03 0.85 0.03
91 INT200311 Htt Positive_regulation of Rest 1 0.05 0.75 0.03
92 INT347164 NOTCH1 Negative_regulation of Gene_expression of EBF1 1 0.03 0.85 0.03
93 INT258529 Binding of JAG1 and NOTCH1 3 0.06 2.44 0
94 INT258528 Binding of NOTCH1 and DLL1 2 0.07 1.6 0
95 INT280849 REST Negative_regulation of Gene_expression of Avp 1 0.09 0.09 0
96 INT291330 Binding of ENO1 and NOTCH1 1 0.03 1.33 0
97 INT193946 Binding of Notch1 and Positive_regulation of Psen1 1 0.03 0.06 0
98 INT196208 REST Regulation of CACNA1A 1 0.46 0.06 0
99 INT327870 Postn Positive_regulation of Gene_expression of Notch1 1 0.37 0.57 0
100 INT196216 Binding of CACNA1A and REST 1 0.28 0 0
101 INT297245 Prnp Positive_regulation of Notch1 1 0.21 0.73 0
102 INT327873 Postn Regulation of Notch1 1 0.41 0 0
103 INT121179 Binding of Htt and Rest 1 0.07 0.45 0
104 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0
105 INT356083 Binding of App and Notch1 1 0.02 0.2 0
106 INT193949 Alph1 Positive_regulation of Notch1 1 0.01 0.08 0
107 INT193950 Alph1 Positive_regulation of Positive_regulation of Notch1 1 0.01 0.07 0
108 INT193948 Binding of Psen1 and Notch1 1 0.02 0 0
109 INT264727 Binding of Notch1 and Mir199b 1 0.00 0.86 0
110 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0
111 INT264728 Mir199b Regulation of Notch1 1 0.01 0.85 0
112 INT280848 Binding of REST and Rest 1 0.02 0.09 0
113 INT303160 Binding of Trim3 and Trim9 1 0.21 0 0
114 INT285770 Binding of NOTCH1 and Das 1 0.00 1.14 0
115 INT264726 Binding of Notch1 and Gtf3a 1 0.00 1.68 0
116 INT356084 Binding of Notch1 and Ncstn 1 0.01 0.07 0
117 INT196215 Binding of L1RE1 and REST 1 0.33 0.47 0
118 INT285769 Das Regulation of NOTCH1 1 0.00 0.78 0
119 INT193947 Notch1 Positive_regulation of Alph1 1 0.01 0.07 0
120 INT291333 Binding of CSHL1 and NOTCH1 1 0.05 1.16 0
121 INT196209 Binding of REST and SNAP25 1 0.25 0 0
122 INT299456 Binding of Gabpa and Notch1 1 0.21 0.09 0
123 INT121178 Binding of Bdnf and Rest 1 0.10 0.91 0
124 INT264725 Binding of Hes1 and Notch1 1 0.03 0.84 0
125 INT280837 Binding of Rest and Negative_regulation of Gene_expression of Avp 1 0.00 0.09 0
126 INT258564 Binding of NOTCH1 and Crlf2 1 0.27 0.67 0
127 INT196214 Binding of FRAXD and REST 1 0.00 0.07 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of calcium ion-dependent exocytosis. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of calcium ion-dependent exocytosis. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
2 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
3 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
4 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
5 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
6 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
7 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
8 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
9 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
10 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
11 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
12 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
13 INT123726 Positive_regulation of Notch1 23 0.70 7.2 5.65
14 INT97693 Gene_expression of REST 29 0.75 5.51 5.26
15 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
16 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
17 INT69217 Gene_expression of Notch1 20 0.78 7.8 4.41
18 INT122323 Positive_regulation of NOTCH1 36 0.70 35.63 3.7
19 INT200248 Gene_expression of Rest 1 0.66 1.25 3.7
20 INT67726 Gene_expression of Notch1 36 0.75 9.77 3.54
21 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
22 INT199255 Binding of Rest 14 0.41 1.43 2.94
23 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
24 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
25 INT139872 Regulation of Notch1 14 0.45 7.69 2.82
26 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
27 INT119025 Gene_expression of NOTCH1 46 0.75 31.32 2.64
28 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
29 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
30 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
31 INT50057 Regulation of Notch1 3 0.39 0.87 2.14
32 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
33 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
34 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
35 INT140036 Positive_regulation of Gene_expression of Notch1 6 0.61 2 1.86
36 INT52633 Negative_regulation of Notch1 4 0.42 2.99 1.84
37 INT153635 Positive_regulation of Gene_expression of REST 10 0.54 1.38 1.6
38 INT6830 Positive_regulation of Notch1 20 0.55 7.91 1.57
39 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
40 INT28367 Positive_regulation of REST 10 0.54 2.07 1.52
41 INT163381 Transcription of Notch1 2 0.69 0.41 1.52
42 INT7780 Positive_regulation of Negative_regulation of Adra2a 2 0.50 0.09 1.48
43 INT7932 Protein_catabolism of Adra2a 1 1.00 0 1.44
44 INT53632 Regulation of Negative_regulation of Adra2a 1 0.23 0.08 1.41
45 INT165005 Binding of REST 26 0.43 2.81 1.39
46 INT29262 Negative_regulation of Binding of Adra2a 4 0.40 0.25 1.37
47 INT130098 Negative_regulation of NOTCH1 11 0.42 5.45 1.33
48 INT95815 Regulation of Positive_regulation of Adra2a 4 0.45 1.45 1.32
49 INT110784 Protein_catabolism of Notch1 8 0.21 2.32 1.31
50 INT7847 Positive_regulation of Localization of Adra2a 2 0.40 0.22 1.28
51 INT149295 Regulation of NOTCH1 10 0.13 4.26 1.22
52 INT79489 Transcription of Adra2a 2 0.61 2.38 1.22
53 INT110780 Localization of Notch1 2 0.06 0.47 1.19
54 INT149292 Localization of NOTCH1 7 0.54 6.11 1.14
55 INT123727 Negative_regulation of Notch1 6 0.21 1.22 1.11
56 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
57 INT20687 Positive_regulation of Regulation of Adra2a 1 0.35 1.07 0.95
58 INT6833 Binding of Notch1 4 0.36 0.05 0.94
59 INT190591 Positive_regulation of Rest 3 0.37 2.52 0.92
60 INT18801 Negative_regulation of Negative_regulation of Adra2a 2 0.43 0 0.91
61 INT200255 Localization of Rest 1 0.68 0.14 0.86
62 INT14770 Localization of Adra2a 2 0.60 0.1 0.78
63 INT18836 Localization of ADRA2A 2 0.38 0.33 0.76
64 INT11102 Negative_regulation of Regulation of Adra2a 2 0.42 1.5 0.71
65 INT140037 Positive_regulation of Positive_regulation of Notch1 2 0.22 1.34 0.69
66 INT7609 Regulation of Positive_regulation of Adra2a 3 0.32 0.59 0.66
67 INT6831 Negative_regulation of Binding of Notch1 1 0.27 0 0.6
68 INT136920 Positive_regulation of Gene_expression of NOTCH1 12 0.49 8.25 0.59
69 INT110782 Negative_regulation of Localization of Notch1 1 0.03 0.33 0.56
70 INT82128 Negative_regulation of Transcription of Adra2a 1 0.18 1.32 0.55
71 INT200273 Negative_regulation of Rest 1 0.43 0.69 0.55
72 INT59394 Regulation of Regulation of Adra2a 1 0.17 0 0.55
73 INT31363 Positive_regulation of Regulation of Adra2a 1 0.04 0 0.55
74 INT149294 Regulation of Localization of NOTCH1 1 0.10 0.9 0.55
75 INT110785 Positive_regulation of Protein_catabolism of Notch1 1 0.05 0.33 0.55
76 INT153634 Regulation of REST 4 0.48 1.42 0.54
77 INT30428 Positive_regulation of Binding of ADRA2A 1 0.34 0.59 0.53
78 INT149297 Protein_catabolism of NOTCH1 2 0.15 0.87 0.51
79 INT77904 Negative_regulation of Gene_expression of Adra2a 2 0.43 0.87 0.5
80 INT41146 Negative_regulation of Localization of Adra2a 1 0.37 0.1 0.49
81 INT29102 Transcription of ADRA2A 2 0.27 0.83 0.46
82 INT158426 Binding of NOTCH1 10 0.36 7.95 0.45
83 INT33171 Positive_regulation of Negative_regulation of Adra2a 1 0.39 0 0.4
84 INT165006 Positive_regulation of Binding of REST 1 0.23 0.94 0.4
85 INT29100 Negative_regulation of Binding of ADRA2A 1 0.19 0.84 0.37
86 INT200269 Negative_regulation of Transcription of Rest 1 0.31 0.08 0.35
87 INT200245 Transcription of Rest 1 0.51 0.08 0.35
88 INT200270 Regulation of Rest 1 0.20 0.07 0.32
89 INT200256 Negative_regulation of Regulation of Rest 1 0.32 0.07 0.32
90 INT29101 Positive_regulation of Transcription of ADRA2A 1 0.19 0.76 0.32
91 INT258685 Regulation of Gene_expression of Notch1 2 0.40 1.45 0.3
92 INT13453 Regulation of Negative_regulation of Adra2a 2 0.27 0.49 0.28
93 INT134176 Gene_expression of ADRA2A 4 0.58 1.45 0.25
94 INT104789 Negative_regulation of REST 3 0.33 0.44 0.23
95 INT25928 Positive_regulation of Negative_regulation of ADRA2A 1 0.05 0 0.23
96 INT316049 Regulation of Regulation of Notch1 1 0.03 0.92 0.23
97 INT130099 Negative_regulation of Positive_regulation of NOTCH1 4 0.43 2.56 0.21
98 INT297241 Positive_regulation of Positive_regulation of Notch1 2 0.40 1.02 0.2
99 INT193945 Binding of Notch1 7 0.15 1.28 0.19
100 INT130096 Positive_regulation of Positive_regulation of NOTCH1 2 0.50 1.15 0.18
101 INT200275 Positive_regulation of Gene_expression of Rest 1 0.59 0.92 0.17
102 INT118123 Localization of STXBP3 1 0.48 0.24 0.14
103 INT297239 Positive_regulation of Gene_expression of Notch1 2 0.40 1.31 0.13
104 INT338718 Positive_regulation of Localization of NOTCH1 1 0.04 0.6 0.13
105 INT316042 Negative_regulation of Gene_expression of Notch1 1 0.27 1.7 0.12
106 INT134177 Positive_regulation of Gene_expression of ADRA2A 1 0.10 0.26 0.12
107 INT134178 Positive_regulation of Regulation of ADRA2A 1 0.10 0.24 0.12
108 INT200281 Negative_regulation of Negative_regulation of Rest 1 0.31 0.44 0.11
109 INT141999 Regulation of Gene_expression of NOTCH1 2 0.04 0.97 0.08
110 INT196248 Localization of REST 1 0.66 0.15 0.08
111 INT327728 Regulation of Gene_expression of Notch1 2 0.27 0.73 0.07
112 INT193845 Localization of Notch1 2 0.78 0.32 0.05
113 INT193850 Regulation of Localization of Notch1 1 0.14 0.33 0.05
114 INT298336 Phosphorylation of Notch1 1 0.02 0.13 0.04
115 INT350959 Transcription of NOTCH1 2 0.05 0.84 0.03
116 INT232397 Protein_catabolism of Notch1 3 0.64 1.56 0
117 INT210662 Transcription of Adra2a 1 0.01 0.09 0
118 INT297242 Transcription of Notch1 1 0.19 0.25 0
119 INT264724 Negative_regulation of Positive_regulation of Notch1 1 0.03 0.77 0
120 INT300174 Negative_regulation of Gene_expression of NOTCH1 1 0.04 0.53 0
121 INT234247 Negative_regulation of Protein_catabolism of NOTCH1 1 0.05 0 0
122 INT303192 Gene_expression of Trim9 1 0.32 0.28 0
123 INT130094 Regulation of Positive_regulation of NOTCH1 1 0.45 0.52 0
124 INT264723 Negative_regulation of Gene_expression of Notch1 1 0.03 0.83 0
125 INT327858 Positive_regulation of Protein_catabolism of Notch1 1 0.45 0.13 0
126 INT196244 Negative_regulation of Gene_expression of REST 1 0.38 0.09 0
127 INT327861 Positive_regulation of Localization of Notch1 1 0.67 0 0
128 INT273836 Positive_regulation of Regulation of Notch1 1 0.15 0.05 0
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