GO:0045963

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Name negative regulation of dopamine metabolic process
Categary Process
Go Slim No
Go Link GO:0045963
Unique Molecular Interactions 44
Total Molecular Interactions 58
Total Single Events 1009
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of dopamine metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of dopamine metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT172203 Binding of Comt and Maoa 1 0.31 0.98 1.43
2 INT128913 Binding of COMT and PENK 1 0.30 0.07 1.41
3 INT128914 COMT Regulation of OPRM1 1 0.39 0.07 1.39
4 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29
5 INT261617 SNRNP70 Regulation of Comt 1 0.01 0.4 1.18
6 INT60208 Binding of Htr1a and Htr2c 2 0.52 0.25 1
7 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94
8 INT165627 Binding of COMT and SLTM 1 0.09 0.86 0.88
9 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
10 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84
11 INT340115 Comt Regulation of Localization of Dusp1 1 0.12 0.83 0.83
12 INT340114 Comt Regulation of Localization of Pain1 1 0.02 0.83 0.83
13 INT340113 Comt Regulation of Bdnf 1 0.21 0.74 0.82
14 INT266100 Binding of COMT and SH2B2 1 0.25 1.22 0.74
15 INT327707 Binding of Comt and Drd1a 1 0.18 0.27 0.74
16 INT266108 Binding of COMT and HPS1 1 0.23 1.21 0.74
17 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
18 INT327712 Binding of Comt and Rbm39 1 0.00 0.27 0.74
19 INT287132 Binding of NT5E and Comt 1 0.03 0.11 0.73
20 INT167455 Binding of MSD and Comt 1 0.15 0.28 0.5
21 INT311616 Binding of MET and Comt 1 0.01 0.2 0.37
22 INT327701 Comt Regulation of Npcd 1 0.01 0 0.29
23 INT328407 Nlrp1a Negative_regulation of Gene_expression of Snca 1 0.07 0.31 0.29
24 INT327706 Comt Regulation of Gopc 1 0.10 0 0.29
25 INT328410 Nlrp1a Negative_regulation of Snca 1 0.07 0.31 0.29
26 INT216040 Binding of Comt and Prodh 1 0.30 1.71 0.26
27 INT287131 Negative_regulation of Binding of NT5E and Comt 1 0.03 0.06 0.23
28 INT266103 Binding of COMT and SNRNP70 1 0.04 0.78 0.21
29 INT202252 COMT Regulation of DRD2 1 0.31 0 0.21
30 INT195423 COMT Negative_regulation of GBE1 1 0.00 0.22 0.19
31 INT317322 Snca Regulation of Positive_regulation of Th 1 0.01 0.23 0.17
32 INT327700 Binding of Comt and 4930579C15Rik 1 0.08 0 0.15
33 INT202253 Binding of COMT and TCN1 1 0.16 0 0.12
34 INT327703 Cish Regulation of Transcription of Comt 1 0.13 0.77 0.12
35 INT287130 Positive_regulation of Binding of NT5E and Comt 1 0.04 0 0.12
36 INT328413 Binding of Snca and Nlrp1a 1 0.06 0.75 0.1
37 INT327709 Uts2r Positive_regulation of Comt 1 0.14 0.47 0.1
38 INT174093 Htr2c Regulation of Gene_expression of Csf2 1 0.00 0 0.09
39 INT174070 Htr2c Positive_regulation of Itpr3 1 0.00 0 0.09
40 INT83270 Snca Regulation of Napepld 1 0.14 0 0.09
41 INT317313 Atp13a2 Negative_regulation of Snca 1 0.13 0.59 0
42 INT154023 Binding of NOVA2 and Comt 1 0.03 0.08 0
43 INT317315 Gene_expression of Snca Negative_regulation of Psmb10 1 0.00 0.52 0
44 INT317320 Binding of Snca and Atp13a2 1 0.08 0.58 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of dopamine metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of dopamine metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49
2 INT101120 Gene_expression of Comt 63 0.77 34.75 26.13
3 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05
4 INT519 Negative_regulation of Comt 52 0.59 17.65 20.39
5 INT135629 Binding of COMT 33 0.48 16.68 19.37
6 INT101119 Negative_regulation of Comt 19 0.58 8.77 13.09
7 INT123593 Gene_expression of Snca 58 0.78 35.76 12.87
8 INT17619 Regulation of COMT 12 0.45 8.46 12.22
9 INT520 Binding of Comt 24 0.48 8.98 12.21
10 INT18001 Positive_regulation of Htr2c 21 0.67 7.63 11.39
11 INT127123 Positive_regulation of Snca 35 0.70 14.76 10.1
12 INT144736 Negative_regulation of Gene_expression of COMT 13 0.58 6.47 9.28
13 INT122952 Positive_regulation of COMT 13 0.50 8.1 8.89
14 INT56775 Binding of Htr2c 16 0.47 3.77 8.74
15 INT9032 Regulation of Htr2c 11 0.60 2.77 7.81
16 INT44537 Positive_regulation of Comt 7 0.69 2.62 7.78
17 INT101121 Regulation of Comt 19 0.53 10.66 7.22
18 INT144739 Regulation of Gene_expression of COMT 11 0.61 3.07 7.08
19 INT150825 Binding of Comt 13 0.42 6.65 6.42
20 INT50712 Gene_expression of Comt 13 0.68 6.33 6.23
21 INT49477 Gene_expression of Htr2c 12 0.75 3.26 5.73
22 INT2162 Regulation of Comt 13 0.60 2.9 5.18
23 INT2871 Positive_regulation of Comt 9 0.50 2.8 4.78
24 INT123594 Negative_regulation of Snca 19 0.59 4.43 4.59
25 INT127122 Positive_regulation of Gene_expression of Snca 11 0.69 15.36 4.56
26 INT52402 Negative_regulation of Htr2c 7 0.42 1.46 4.21
27 INT172197 Positive_regulation of Gene_expression of Comt 12 0.69 7.61 4.06
28 INT172198 Protein_catabolism of Comt 7 0.88 2.78 3.6
29 INT206598 Regulation of Gene_expression of Comt 9 0.60 6 3.56
30 INT63621 Transcription of Htr2c 6 0.52 0.62 3.49
31 INT195964 Transcription of Comt 8 0.71 4.72 3.4
32 INT119412 Gene_expression of Snca 15 0.66 11.27 3.39
33 INT55236 Regulation of Htr2c 6 0.44 3.31 3.36
34 INT123595 Regulation of Snca 7 0.62 4.3 3.06
35 INT65000 Positive_regulation of Positive_regulation of Htr2c 4 0.67 0.69 2.8
36 INT194289 Transcription of COMT 3 0.72 3.56 2.72
37 INT202257 Localization of COMT 7 0.75 2.13 2.65
38 INT128983 Protein_catabolism of Comt 5 0.87 0.22 2.6
39 INT206593 Negative_regulation of Gene_expression of Comt 3 0.56 1.68 2.52
40 INT265662 Negative_regulation of Binding of COMT 4 0.37 1.29 2.42
41 INT77309 Positive_regulation of Htr2c 3 0.49 2.72 2.25
42 INT64505 Localization of Htr2c 3 0.78 0.87 2.24
43 INT69020 Gene_expression of Htr2c 9 0.74 6.09 2.22
44 INT136962 Protein_catabolism of COMT 4 0.89 1.12 2.14
45 INT127124 Regulation of Gene_expression of Snca 2 0.62 0.17 2.03
46 INT127125 Localization of Snca 6 0.81 8.24 1.88
47 INT447 Localization of Comt 4 0.75 0.76 1.8
48 INT74088 Negative_regulation of Positive_regulation of Htr2c 1 0.41 0 1.75
49 INT265659 Positive_regulation of Negative_regulation of COMT 1 0.43 0.78 1.57
50 INT201271 Phosphorylation of Snca 3 0.82 4.22 1.45
51 INT124247 Negative_regulation of Gene_expression of Snca 12 0.59 3.87 1.39
52 INT272340 Transcription of Htr2c 1 0.52 2.77 1.28
53 INT65165 Positive_regulation of Negative_regulation of Comt 1 0.03 0 1.15
54 INT151753 Transcription of Snca 6 0.69 1.99 1.11
55 INT292945 Positive_regulation of Positive_regulation of Snca 4 0.69 2.42 1.05
56 INT286344 Positive_regulation of Gene_expression of Snca 1 0.41 2.84 1.03
57 INT246088 Negative_regulation of Negative_regulation of COMT 2 0.37 2.01 1
58 INT151752 Positive_regulation of Transcription of Snca 2 0.50 0.99 0.92
59 INT124246 Binding of Snca 10 0.37 6.53 0.9
60 INT282479 Regulation of Protein_catabolism of Comt 2 0.45 1.17 0.85
61 INT265663 Positive_regulation of Gene_expression of COMT 2 0.50 0.26 0.79
62 INT195983 Localization of Comt 2 0.74 0.93 0.76
63 INT344931 Positive_regulation of Protein_catabolism of Comt 1 0.49 0 0.76
64 INT136963 Regulation of Protein_catabolism of COMT 1 0.24 0.49 0.72
65 INT125261 Positive_regulation of Gene_expression of Htr2c 2 0.67 2.22 0.7
66 INT272356 Positive_regulation of Transcription of Htr2c 1 0.45 1.66 0.63
67 INT100754 Negative_regulation of Binding of Htr2c 1 0.41 0.49 0.57
68 INT230986 Positive_regulation of Transcription of Htr2c 1 0.45 0.25 0.49
69 INT265655 Regulation of Positive_regulation of COMT 1 0.39 0.38 0.49
70 INT327677 Regulation of Transcription of Comt 2 0.60 1.49 0.48
71 INT174055 Negative_regulation of Htr2c 5 0.41 2.63 0.45
72 INT266128 Positive_regulation of Transcription of COMT 1 0.44 0.35 0.41
73 INT50711 Regulation of Gene_expression of Comt 2 0.01 0 0.39
74 INT211023 Positive_regulation of Gene_expression of Htr2c 2 0.45 2.03 0.33
75 INT266123 Negative_regulation of Transcription of COMT 1 0.59 0.65 0.3
76 INT287124 Negative_regulation of Protein_catabolism of Comt 1 0.38 0.22 0.29
77 INT266127 Regulation of Binding of COMT 1 0.39 0.54 0.27
78 INT211029 Negative_regulation of Gene_expression of Htr2c 1 0.56 2.54 0.25
79 INT287126 Negative_regulation of Negative_regulation of Comt 1 0.37 0.78 0.25
80 INT266124 Positive_regulation of Binding of COMT 1 0.44 0 0.23
81 INT142052 Binding of Snca 4 0.47 1.02 0.22
82 INT266122 Regulation of Localization of COMT 1 0.39 0 0.21
83 INT292944 Regulation of Positive_regulation of Snca 1 0.45 0.36 0.21
84 INT327698 Regulation of Binding of Comt 1 0.39 0 0.2
85 INT174049 Positive_regulation of Negative_regulation of Htr2c 1 0.01 0 0.19
86 INT257418 Negative_regulation of Transcription of Snca 1 0.43 0.93 0.19
87 INT174053 Phosphorylation of Htr2c 1 0.01 0.06 0.18
88 INT327691 Negative_regulation of Transcription of Comt 1 0.37 0.33 0.18
89 INT327679 Regulation of Positive_regulation of Comt 1 0.39 0.39 0.17
90 INT157084 Localization of Snca 1 0.51 0.17 0.16
91 INT319289 Protein_catabolism of Snca 1 0.35 0.93 0.15
92 INT286343 Negative_regulation of Gene_expression of Snca 1 0.26 0.65 0.15
93 INT272355 Regulation of Regulation of Htr2c 1 0.44 1.1 0.14
94 INT209806 Transcription of Comt 1 0.69 2.12 0.11
95 INT288642 Negative_regulation of Positive_regulation of Snca 1 0.07 0.93 0.09
96 INT266125 Regulation of Transcription of COMT 1 0.24 0.88 0.08
97 INT292946 Positive_regulation of Localization of Snca 1 0.50 0.52 0.06
98 INT174050 Binding of Htr2c 1 0.01 0 0.06
99 INT211025 Regulation of Gene_expression of Htr2c 1 0.43 1.01 0.06
100 INT317275 Positive_regulation of Binding of Snca 1 0.37 0.53 0
101 INT292012 Positive_regulation of Localization of COMT 1 0.44 0.13 0
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