GO:0045987

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Name positive regulation of smooth muscle contraction
Categary Process
Go Slim No
Go Link GO:0045987
Unique Molecular Interactions 625
Total Molecular Interactions 818
Total Single Events 11455
Pain Genes Associated 40

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of smooth muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of smooth muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
2 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37
3 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
4 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
5 INT91607 Binding of EDN1 and POMC 1 0.12 0 1.9
6 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
7 INT141907 F2r Regulation of Plat 1 0.46 0 1.59
8 INT136034 Edn1 Regulation of Trpv1 2 0.66 0.39 1.58
9 INT190773 Il4 Negative_regulation of Gene_expression of Ptgs2 1 0.06 1.26 1.45
10 INT190774 Il4 Negative_regulation of Positive_regulation of Ptgs2 1 0.06 1.26 1.45
11 INT132412 Negative_regulation of Ngf Negative_regulation of Ptgs1 1 0.01 0.81 1.31
12 INT95275 Binding of Edn1 and Ece1 1 0.32 2.09 1.3
13 INT95274 Regulation of Binding of Edn1 and Ece1 1 0.39 2.09 1.3
14 INT105295 WAS Regulation of PTGS1 1 0.02 0.13 1.27
15 INT103031 Calca Positive_regulation of Ptgs1 2 0.46 0.98 1.22
16 INT77806 Edn1 Regulation of Gene_expression of Ptgs2 1 0.29 1.24 1.22
17 INT62596 Binding of Edn1 and Nppa 1 0.27 1.77 1.22
18 INT201067 Binding of Edn1 and Ednra 2 0.18 1.36 1.18
19 INT207116 F2 Positive_regulation of F2r 5 0.12 2.16 1.16
20 INT353338 F2r Positive_regulation of Localization of Mif 1 0.68 1.25 1.16
21 INT195117 Ptgs2 Positive_regulation of Gene_expression of Il6 1 0.10 3.26 1.16
22 INT338053 F2r Positive_regulation of Localization of Calca 1 0.06 0.47 1.15
23 INT10238 Binding of EDN1 and Calca 1 0.00 1.07 1.06
24 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04
25 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
26 INT54853 Negative_regulation of Adra1a Positive_regulation of Positive_regulation of Ins1 1 0.18 0.23 1
27 INT54852 Negative_regulation of Adra1a Positive_regulation of Ins1 1 0.18 0.23 0.99
28 INT60213 Binding of Ptgs1 and Ptgs2 2 0.37 0.5 0.97
29 INT152084 Edn1 Negative_regulation of Positive_regulation of Trpv1 1 0.62 0.48 0.96
30 INT61037 Och Positive_regulation of Ptgs1 1 0.00 0 0.95
31 INT136033 Edn1 Positive_regulation of Trpv1 1 0.50 0.34 0.95
32 INT77859 EDN1 Positive_regulation of MC1R 2 0.64 0.34 0.94
33 INT199396 Prok2 Regulation of Trpv1 1 0.43 1.23 0.94
34 INT207149 Binding of F2r and Par2 1 0.17 1.64 0.92
35 INT199392 Pklr Positive_regulation of Prok2 1 0.34 1.3 0.91
36 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
37 INT199393 Prok2 Positive_regulation of Prokr1 1 0.48 1.3 0.9
38 INT199389 Prok2 Positive_regulation of Localization of Il1f5 1 0.05 1.17 0.88
39 INT116559 Olr1627 Negative_regulation of Regulation of Ptgs2 1 0.01 1.52 0.86
40 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84
41 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
42 INT152083 Binding of Edn1 and Trpv1 1 0.38 0.67 0.83
43 INT153765 Positive_regulation of Edn1 Positive_regulation of Gtf3a 2 0.04 2.26 0.82
44 INT106859 EDN1 Positive_regulation of Transcription of MC1R 1 0.22 0 0.82
45 INT53377 Binding of Edn1 and Edn3 1 0.39 0 0.81
46 INT157918 TRPV1 Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
47 INT157913 Trpv1 Regulation of Gene_expression of Edn1 1 0.29 0.55 0.81
48 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
49 INT219911 Edn1 Regulation of Gene_expression of Trpv1 1 0.23 0.57 0.8
50 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79
51 INT200094 Negative_regulation of Jun Negative_regulation of Gene_expression of Ptgs2 1 0.01 2.87 0.78
52 INT158068 Positive_regulation of Pparg Positive_regulation of Positive_regulation of PTGS2 1 0.01 0.28 0.76
53 INT119314 Ptgs1 Regulation of Gene_expression of Ptger2 1 0.01 0.6 0.73
54 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
55 INT64117 Binding of Edn1 and Ins1 1 0.06 0.85 0.71
56 INT222493 Edn1 Positive_regulation of Localization of Prl 1 0.10 0 0.71
57 INT338057 Positive_regulation of F2r Positive_regulation of Localization of Calca 1 0.05 0.28 0.71
58 INT63557 Binding of Edn1 and Edn3 1 0.23 0.63 0.7
59 INT114735 Mtx1 Regulation of Ptgs1 1 0.01 0.31 0.69
60 INT324900 VEGFA Positive_regulation of Gene_expression of Edn1 1 0.06 1.61 0.69
61 INT199394 Prok2 Regulation of Positive_regulation of Prokr1 1 0.28 0.89 0.68
62 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67
63 INT150338 Binding of F2 and F2R 1 0.11 0.4 0.67
64 INT313702 Binding of Edn1 and Fig4 1 0.16 0 0.65
65 INT313698 Binding of Calca and Edn1 1 0.30 0 0.65
66 INT94020 Binding of EDN2 and INSRR 1 0.03 0 0.65
67 INT182266 EDN1 Positive_regulation of Gene_expression of MMP13 1 0.35 2.03 0.63
68 INT219919 EDNRA Negative_regulation of Edn1 1 0.15 0.36 0.63
69 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62
70 INT71942 Negative_regulation of PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.62
71 INT101320 Negative_regulation of Ptgs1 Positive_regulation of Ptgs2 1 0.03 0.2 0.62
72 INT55672 Ptgs1 Positive_regulation of Gene_expression of Ik 1 0.03 0.75 0.61
73 INT71944 PTGS2 Negative_regulation of VN1R106P 1 0.00 0.07 0.61
74 INT147890 Prok2 Positive_regulation of Localization of Abat 1 0.18 0.36 0.6
75 INT131642 Edn1 Positive_regulation of Positive_regulation of Insrr 1 0.01 0.44 0.6
76 INT178087 EDN1 Positive_regulation of MMP13 2 0.23 1.58 0.59
77 INT137247 Slc6a14 Negative_regulation of Ptgs2 2 0.19 1.38 0.58
78 INT137248 Slc6a14 Negative_regulation of Gene_expression of Ptgs2 1 0.19 1.32 0.58
79 INT125546 Arsa Negative_regulation of Gene_expression of PTGS2 1 0.00 0.53 0.58
80 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58
81 INT130162 Pomc Positive_regulation of Gene_expression of Edn1 1 0.25 0 0.58
82 INT253070 Prok2 Regulation of Gene_expression of Ik 1 0.01 0.6 0.56
83 INT196879 Cpox Negative_regulation of Gene_expression of Tbxa2r 1 0.04 0.8 0.56
84 INT167907 Binding of F2r and ITS 1 0.01 0.7 0.55
85 INT254197 Mif Regulation of Ptgs2 1 0.02 1.08 0.55
86 INT71943 Regulation of ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.54
87 INT129912 Skiv2l Negative_regulation of Gene_expression of PTGS2 1 0.00 0.87 0.54
88 INT62597 Binding of Edn1 and Vip 1 0.23 0.79 0.54
89 INT76200 CASP1 Positive_regulation of Gene_expression of PTGS1 1 0.05 0.16 0.54
90 INT161251 Ptgs2 Regulation of Mapk14 1 0.16 0.82 0.54
91 INT71945 ZNF697 Negative_regulation of PTGS2 1 0.01 0.07 0.53
92 INT110474 YY1 Positive_regulation of Positive_regulation of EDN1 1 0.56 0.15 0.53
93 INT79809 Binding of Agtr1a and Adra1a 1 0.02 0.23 0.53
94 INT130160 Pomc Regulation of Edn1 1 0.25 0 0.53
95 INT69882 Ptger2 Positive_regulation of Gene_expression of Ptgs2 1 0.19 0.6 0.52
96 INT338038 Gopc Regulation of Gene_expression of F2r 1 0.08 0 0.52
97 INT338045 F2r Regulation of Localization of Calca 1 0.03 0.05 0.52
98 INT116541 Binding of Ptgs2 and ZNF398 1 0.00 0.68 0.52
99 INT105849 Il1b Positive_regulation of Positive_regulation of Ptgs1 1 0.07 0.38 0.51
100 INT78590 Nos2 Positive_regulation of PTGS1 2 0.00 0.85 0.5
101 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49
102 INT94015 Binding of EDN1 and INSRR 1 0.04 0 0.49
103 INT94024 Binding of EDN1 and EDN3 1 0.27 0 0.49
104 INT150205 Tnrc6a Negative_regulation of PTGS2 1 0.00 0.42 0.49
105 INT135584 CSF2 Regulation of PTGS2 1 0.06 1.28 0.49
106 INT150788 ZNF398 Regulation of PTGS2 1 0.02 0.5 0.48
107 INT348402 LPA Positive_regulation of Gene_expression of Ptgs2 1 0.01 0.62 0.48
108 INT94018 Binding of EDN2 and EDN3 1 0.19 0 0.48
109 INT131809 Nfkb1 Positive_regulation of Gene_expression of Ptgs1 1 0.12 0.73 0.48
110 INT129551 Sag Negative_regulation of Gene_expression of Ptgs1 1 0.08 0.88 0.48
111 INT62164 Il1b Positive_regulation of PTGS2 1 0.00 0.49 0.47
112 INT99571 Edn1 Positive_regulation of Localization of Ednra 1 0.01 0.32 0.47
113 INT62163 Il1b Positive_regulation of Positive_regulation of PTGS2 1 0.00 0.49 0.47
114 INT145434 Binding of HMOX1 and PTGS2 1 0.02 0.41 0.47
115 INT145436 Binding of HMOX2 and PTGS2 1 0.02 0.41 0.47
116 INT71839 Chrm3 Positive_regulation of Qrfp 1 0.09 0 0.47
117 INT127662 Negative_regulation of PDE4A Negative_regulation of Gene_expression of PTGS2 1 0.15 0.75 0.47
118 INT103026 Ptgis Positive_regulation of Ptgs1 1 0.02 0.42 0.46
119 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
120 INT103029 Calca Positive_regulation of Positive_regulation of Ptgs1 1 0.12 0.41 0.46
121 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
122 INT110475 EDN1 Regulation of PRKCA 1 0.05 0.07 0.45
123 INT349686 Nmu Positive_regulation of Nmur1 1 0.36 0.2 0.45
124 INT219910 EDN1 Positive_regulation of Positive_regulation of EDNRA 1 0.00 0.3 0.45
125 INT253075 Prok2 Negative_regulation of Gene_expression of Il10 1 0.24 0.24 0.45
126 INT47101 Adra1a Regulation of Localization of Gnrhr 1 0.02 0.24 0.44
127 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44
128 INT69163 Tlr4 Positive_regulation of Ptgs1 1 0.02 0.08 0.44
129 INT353331 Elane Positive_regulation of F2r 1 0.08 0.78 0.44
130 INT313704 Smn1 Negative_regulation of Gene_expression of Edn1 1 0.32 0 0.42
131 INT53470 Acsm3 Regulation of Ptgs1 1 0.15 0 0.42
132 INT53469 Negative_regulation of Acsm3 Regulation of Ptgs1 1 0.24 0 0.42
133 INT338059 Nrtn Positive_regulation of Gene_expression of F2r 1 0.12 0.45 0.41
134 INT153766 Edn1 Positive_regulation of Gtf3a 1 0.04 1.25 0.41
135 INT53471 Binding of Ptgs1 and Acsm3 1 0.17 0 0.41
136 INT91107 Positive_regulation of Ptgs1 Positive_regulation of Localization of Crh 1 0.00 0.56 0.41
137 INT253076 Prok2 Positive_regulation of Ik 1 0.02 0.49 0.41
138 INT156237 Binding of F2r and Tnfsf14 1 0.02 1.14 0.4
139 INT230724 EDN1 Positive_regulation of EDNRA 3 0.24 4.12 0.39
140 INT106505 Binding of Ptgds and Ptgs2 1 0.01 0.93 0.39
141 INT200096 Negative_regulation of Il1a Negative_regulation of Gene_expression of Ptgs2 1 0.00 1.45 0.39
142 INT353332 Binding of F2r and Pawr 1 0.18 0.67 0.39
143 INT50553 Negative_regulation of Ptgs1 Negative_regulation of Gene_expression of Tbxa2r 1 0.02 1.37 0.38
144 INT310600 Tbxa2r Positive_regulation of PLEK 1 0.53 0.45 0.38
145 INT139566 Binding of PLEK and Tbxa2r 1 0.01 1.14 0.38
146 INT99399 Penk Positive_regulation of Edn1 1 0.00 0 0.38
147 INT99400 Gast Positive_regulation of Edn1 1 0.00 0 0.38
148 INT157171 Binding of PTGS2 and Pla2g1b 1 0.02 0.26 0.37
149 INT173704 Binding of PCOS1 and Edn1 1 0.01 0.99 0.37
150 INT313701 Calca Negative_regulation of Binding of Edn1 1 0.30 0.14 0.37
151 INT74244 Ptgs1 Regulation of Positive_regulation of Penk 1 0.09 0.19 0.37
152 INT93694 Binding of Hspa8 and Ptgs1 1 0.30 0.79 0.36
153 INT152314 Il18 Regulation of Edn1 1 0.02 0.22 0.36
154 INT201068 Binding of Edn1 and Ednrb 2 0.18 1.23 0.35
155 INT279369 Binding of ADA and Ifx 1 0.29 0.27 0.35
156 INT167045 TRPA1 Regulation of PTGS1 1 0.19 0.1 0.35
157 INT152316 Ifng Regulation of Edn1 1 0.01 0.22 0.35
158 INT278766 HOXA9 Positive_regulation of Gene_expression of PTGS2 1 0.43 1.28 0.35
159 INT278749 NUP98 Positive_regulation of Gene_expression of PTGS2 1 0.46 1.28 0.35
160 INT89501 Il6 Positive_regulation of Ptgs2 1 0.01 1.07 0.35
161 INT203395 Edn1 Positive_regulation of Vegfa 1 0.06 1.59 0.35
162 INT156235 Tnfsf14 Positive_regulation of F2r 1 0.03 1.03 0.35
163 INT161796 Binding of ECE1 and EDN1 2 0.21 2.23 0.34
164 INT25354 Chi3l1 Negative_regulation of Ptgs1 1 0.00 0.39 0.34
165 INT89505 Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
166 INT5388 PTGS1 Negative_regulation of APRT 1 0.21 0.4 0.34
167 INT134303 Cpox Negative_regulation of PTGS2 1 0.00 0.77 0.34
168 INT126531 Adra1a Positive_regulation of Serpine1 1 0.03 0.31 0.34
169 INT89502 Positive_regulation of Nos2 Positive_regulation of Ptgs2 1 0.05 1.07 0.34
170 INT207576 RETN Positive_regulation of Gene_expression of EDN1 1 0.05 0.78 0.33
171 INT68557 ZNF697 Negative_regulation of PTGS1 1 0.02 0.59 0.33
172 INT44654 Phc1 Negative_regulation of Adra1a 1 0.00 0.4 0.33
173 INT143567 Edn1 Regulation of Ptgs2 1 0.26 0.17 0.33
174 INT253072 Pbrgcsf1 Positive_regulation of Gene_expression of Prok2 1 0.15 0.44 0.33
175 INT99842 Edn1 Negative_regulation of Localization of Ren 1 0.24 0.43 0.32
176 INT353333 Positive_regulation of F2r Positive_regulation of Localization of Mif 1 0.46 0.26 0.32
177 INT347517 Binding of Tbxa2r and ST7L 1 0.00 0 0.32
178 INT52700 Prkcg Positive_regulation of Ptgs2 1 0.12 0.3 0.32
179 INT353334 F2r Positive_regulation of Mif 1 0.68 0 0.32
180 INT67266 Edn1 Negative_regulation of Ece1 1 0.19 0.17 0.32
181 INT108879 Negative_regulation of PTGS2 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.43 0.31
182 INT182262 EDN1 Positive_regulation of Gene_expression of NOS2 1 0.28 0.79 0.31
183 INT64859 Negative_regulation of PTGS1 Negative_regulation of PTGS2 1 0.07 0.05 0.31
184 INT59326 Binding of Adra1a and Positive_regulation of Binding of Npy 1 0.44 0 0.31
185 INT71519 Edn1 Positive_regulation of Gene_expression of Adarb1 1 0.02 0.48 0.31
186 INT116594 Negative_regulation of PTGS2 Negative_regulation of Gene_expression of IL6 1 0.22 0.45 0.31
187 INT353335 F2r Regulation of Positive_regulation of Mif 1 0.27 0.11 0.31
188 INT213062 PTGS1 Regulation of Gene_expression of MMP9 1 0.04 0.25 0.3
189 INT139044 AKR1B1 Regulation of Gene_expression of PTGS2 1 0.09 0.37 0.3
190 INT191799 PROC Negative_regulation of Binding of F2r 1 0.00 0.92 0.3
191 INT156084 Binding of PTGS2 and AKR1C3 1 0.02 0.31 0.3
192 INT156082 Binding of PTGS1 and AKR1C3 1 0.01 0.31 0.3
193 INT65539 PTGS1 Positive_regulation of Positive_regulation of Nfkb1 1 0.06 0.18 0.3
194 INT93833 Binding of Fos and Srf 1 0.00 0 0.3
195 INT62207 Binding of PTGS1 and PTGS2 3 0.06 0.07 0.29
196 INT74942 HGF Positive_regulation of PTGS1 1 0.11 0.25 0.29
197 INT265467 HRAS Negative_regulation of Gene_expression of PTGS2 1 0.01 0.84 0.29
198 INT65540 Gene_expression of PTGS1 Positive_regulation of Positive_regulation of Nfkb1 1 0.05 0.17 0.29
199 INT93832 Binding of Elk1 and Srf 1 0.00 0 0.29
200 INT353336 F2r Regulation of Localization of Mif 1 0.23 0.24 0.28

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of smooth muscle contraction. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of smooth muscle contraction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26
2 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
3 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6
4 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
5 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58
6 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97
7 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
8 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
9 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5
10 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
11 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04
12 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
13 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
14 INT5781 Gene_expression of Edn1 190 0.78 99.1 46
15 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41
16 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
17 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19
18 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15
19 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
20 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18
21 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95
22 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43
23 INT50490 Regulation of PTGS2 80 0.48 39.51 25.85
24 INT9886 Gene_expression of Ptgs1 92 0.77 40.66 25.31
25 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07
26 INT15390 Positive_regulation of Edn1 64 0.70 47.36 23.8
27 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29
28 INT2978 Gene_expression of Tbxa2r 76 0.77 28.4 21.27
29 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18
30 INT17848 Binding of PTGS2 70 0.46 32.1 20.6
31 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49
32 INT8662 Positive_regulation of EDN1 144 0.70 125.34 19.59
33 INT5048 Binding of Edn1 55 0.47 18.86 19.16
34 INT118512 Gene_expression of F2r 33 0.63 26.56 18.26
35 INT9197 Binding of PTGS1 44 0.48 18.48 16.26
36 INT149816 Gene_expression of Prok2 21 0.78 18.99 15.68
37 INT32802 Negative_regulation of Ada 21 0.57 4.03 14.87
38 INT9191 Localization of EDN1 94 0.81 57.01 14.78
39 INT52696 Positive_regulation of Ptgs2 48 0.70 27.65 14.44
40 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42
41 INT53080 Positive_regulation of Ptgs1 42 0.42 23.58 14.37
42 INT5806 Regulation of Edn1 63 0.62 23.46 13.88
43 INT6365 Localization of Edn1 56 0.81 18.84 13.83
44 INT18658 Regulation of Adra1a 34 0.62 5.69 13.78
45 INT44 Positive_regulation of Adra1a 30 0.68 7.09 12.73
46 INT21979 Negative_regulation of EDN1 52 0.58 24.65 12.55
47 INT59080 Negative_regulation of Gene_expression of PTGS2 55 0.58 22.92 12.39
48 INT12992 Negative_regulation of Gene_expression of Ptgs1 33 0.42 20.47 11.77
49 INT20457 Regulation of Ptgs1 23 0.48 11.63 11.56
50 INT787 Localization of Ptgs1 31 0.80 12.36 11.55
51 INT53082 Positive_regulation of Gene_expression of Ptgs2 47 0.64 25.39 11.39
52 INT14124 Negative_regulation of Adra1a 34 0.59 7.48 10.85
53 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6
54 INT53081 Negative_regulation of Gene_expression of Ptgs2 29 0.59 15.83 10.39
55 INT348 Regulation of Adra1a 25 0.45 3.33 10.27
56 INT10184 Regulation of EDN1 44 0.62 23.78 10.06
57 INT85535 Negative_regulation of Gene_expression of Ptgs2 27 0.51 16.04 10.01
58 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98
59 INT475 Negative_regulation of Adra1a 28 0.58 7.87 9.83
60 INT6361 Localization of Edn1 30 0.81 19.09 9.7
61 INT11859 Positive_regulation of Tbxa2r 44 0.61 22.62 9.61
62 INT69321 Regulation of Gene_expression of PTGS2 27 0.61 13.27 9.53
63 INT18145 Positive_regulation of Gene_expression of Tbxa2r 30 0.66 18.91 9.52
64 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27
65 INT7697 Positive_regulation of Adra1a 22 0.68 2.3 9.16
66 INT12991 Negative_regulation of Gene_expression of PTGS1 28 0.41 13.39 8.9
67 INT23264 Negative_regulation of Positive_regulation of Ptgs1 16 0.39 8.47 8.9
68 INT5458 Negative_regulation of Tbxa2r 31 0.54 10.58 8.89
69 INT17101 Positive_regulation of Gene_expression of Edn1 24 0.69 24.9 8.86
70 INT12095 Negative_regulation of Edn1 26 0.59 12.01 8.79
71 INT52442 Binding of Ptgs1 16 0.35 9.05 8.78
72 INT6573 Regulation of Negative_regulation of Ptgs1 19 0.45 6.16 8.71
73 INT10237 Binding of EDN1 40 0.48 16 8.48
74 INT19107 Positive_regulation of Tbxa2r 23 0.62 12.54 8.44
75 INT15592 Positive_regulation of F2r 17 0.67 8.66 8.36
76 INT19829 Negative_regulation of Gene_expression of Tbxa2r 32 0.56 12.78 8.3
77 INT117497 Positive_regulation of F2r 18 0.57 14.45 8.13
78 INT34009 Binding of Tbxa2r 33 0.36 17.98 8.01
79 INT1448 Binding of Adra1a 23 0.48 1.41 8.01
80 INT4663 Positive_regulation of Ada 17 0.69 9.48 7.93
81 INT20234 Regulation of Gene_expression of Ptgs1 11 0.44 6.55 7.72
82 INT20348 Negative_regulation of Tbxa2r 47 0.59 19.88 7.68
83 INT10899 Positive_regulation of Gene_expression of Edn1 32 0.70 24.88 7.65
84 INT52688 Transcription of Ptgs2 16 0.69 8.31 7.52
85 INT11042 Localization of Tbxa2r 26 0.76 10.15 7.24
86 INT49751 Negative_regulation of Positive_regulation of PTGS1 12 0.45 4.73 7.23
87 INT10104 Negative_regulation of Edn1 43 0.59 15.63 7.2
88 INT11858 Localization of Tbxa2r 39 0.80 21.24 7.09
89 INT90097 Localization of PTGS2 15 0.69 6.14 6.63
90 INT59079 Transcription of PTGS2 30 0.72 14.21 6.52
91 INT7842 Gene_expression of Adra1a 14 0.67 1.99 6.39
92 INT25130 Positive_regulation of Negative_regulation of Ptgs1 14 0.50 5.07 6.29
93 INT67656 Positive_regulation of Positive_regulation of PTGS2 12 0.46 4.83 6.17
94 INT17370 Negative_regulation of Negative_regulation of Ptgs1 16 0.22 6.5 6.12
95 INT195 Gene_expression of C4a 16 0.48 15.55 6.1
96 INT144086 Positive_regulation of Prok2 12 0.69 9.54 6.06
97 INT78955 Regulation of Gene_expression of Ptgs2 12 0.62 7.22 6.02
98 INT335 Binding of Adra1a 16 0.36 6.16 6
99 INT48004 Positive_regulation of Negative_regulation of PTGS1 12 0.49 4.07 5.87
100 INT112530 Localization of Ptgs2 13 0.70 7.77 5.86
101 INT91712 Localization of Prok2 11 0.80 8 5.85
102 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71
103 INT29674 Gene_expression of Ada 16 0.78 4.59 5.69
104 INT30206 Negative_regulation of ADA 17 0.59 10.03 5.63
105 INT50491 Regulation of Gene_expression of PTGS1 17 0.47 6 5.4
106 INT68202 Gene_expression of ADA 26 0.68 23.15 5.18
107 INT39256 Localization of PTGS1 17 0.74 6.62 5.1
108 INT36256 Regulation of Ada 9 0.62 4.99 5.07
109 INT9767 Negative_regulation of Ada 5 0.55 0.06 5.06
110 INT19639 Negative_regulation of Gene_expression of Tbxa2r 17 0.55 7.69 5.01
111 INT17803 Regulation of Edn1 14 0.54 4.75 4.71
112 INT90852 Gene_expression of F2r 26 0.78 5.5 4.66
113 INT62500 Transcription of Ptgs1 10 0.56 4.54 4.52
114 INT73309 Regulation of Negative_regulation of PTGS2 14 0.44 9.55 4.5
115 INT75440 Regulation of Binding of Edn1 4 0.38 1.41 4.33
116 INT52616 Negative_regulation of Positive_regulation of PTGS2 13 0.43 4.95 4.13
117 INT109861 Gene_expression of Rhoa 11 0.78 5.67 4.02
118 INT134590 Localization of ADA 7 0.65 8.43 3.96
119 INT29394 Gene_expression of Adra1a 9 0.77 3.62 3.91
120 INT115773 Negative_regulation of Localization of Ptgs2 6 0.43 2.99 3.81
121 INT9077 Regulation of Tbxa2r 13 0.45 5.49 3.75
122 INT53200 Binding of Ptgs2 11 0.48 5.08 3.54
123 INT95272 Regulation of Gene_expression of Edn1 19 0.53 17.85 3.42
124 INT72798 Binding of ADA 12 0.47 7.84 3.39
125 INT46754 Localization of F2r 7 0.78 2.36 3.24
126 INT19392 Gene_expression of Ada 9 0.77 7.4 3.17
127 INT52694 Negative_regulation of Positive_regulation of Ptgs2 9 0.43 4.72 3.11
128 INT77615 Positive_regulation of Negative_regulation of Ptgs1 6 0.50 1.55 3.11
129 INT34604 Binding of Ada 11 0.31 4.15 3.1
130 INT9766 Positive_regulation of Ada 2 0.47 0.4 3.09
131 INT58433 Negative_regulation of F2r 9 0.59 2.77 3.08
132 INT53374 Binding of Edn1 17 0.43 11.66 2.98
133 INT131494 Regulation of ADA 8 0.52 7.37 2.97
134 INT135575 Gene_expression of Prok2 7 0.73 2.51 2.95
135 INT78253 Gene_expression of Npy2r 7 0.77 1.49 2.89
136 INT90402 Positive_regulation of Gene_expression of Ptgs1 13 0.31 4.83 2.88
137 INT569 Negative_regulation of C4a 13 0.42 9.48 2.85
138 INT112093 Transcription of Nmu 2 0.68 1.09 2.8
139 INT68505 Positive_regulation of Negative_regulation of PTGS2 8 0.49 2.26 2.76
140 INT100014 Negative_regulation of Gene_expression of EDN1 17 0.42 7.85 2.71
141 INT144085 Negative_regulation of Prok2 2 0.43 2.49 2.71
142 INT4114 Gene_expression of Srf 9 0.70 6.11 2.63
143 INT82653 Regulation of F2r 8 0.36 3.78 2.62
144 INT138437 Gene_expression of Sphk1 23 0.65 10.01 2.61
145 INT27607 Localization of Ptgs1 7 0.59 3.22 2.6
146 INT127176 Transcription of Ptgs2 8 0.58 4.68 2.58
147 INT34969 Negative_regulation of Binding of Ptgs1 4 0.37 1.55 2.55
148 INT17846 Binding of Ptgs2 8 0.32 4.66 2.48
149 INT149811 Positive_regulation of Gene_expression of Prok2 4 0.69 2.54 2.48
150 INT25166 Regulation of Tbxa2r 12 0.43 5.94 2.47
151 INT140363 Negative_regulation of Rhoa 7 0.58 2.49 2.47
152 INT150339 Gene_expression of F2R 10 0.73 3.59 2.46
153 INT70197 Negative_regulation of Positive_regulation of Ptgs1 6 0.24 2.61 2.44
154 INT17243 Positive_regulation of Gene_expression of Tbxa2r 7 0.55 4.7 2.37
155 INT53476 Positive_regulation of Localization of Ptgs1 6 0.49 2.88 2.35
156 INT9887 Negative_regulation of Gene_expression of Ptgs1 7 0.42 2.94 2.3
157 INT78958 Regulation of Negative_regulation of Ptgs2 6 0.42 2.61 2.3
158 INT57664 Gene_expression of Npy2r 4 0.19 1.41 2.26
159 INT81312 Positive_regulation of Gene_expression of Ada 2 0.50 1.58 2.26
160 INT152538 Gene_expression of Nmu 7 0.74 1.12 2.25
161 INT88241 Positive_regulation of Positive_regulation of Ptgs1 3 0.45 1.71 2.25
162 INT55853 Positive_regulation of Positive_regulation of Edn1 11 0.61 6.5 2.21
163 INT82652 Negative_regulation of F2r 4 0.37 3.5 2.19
164 INT47543 Positive_regulation of Chrm3 11 0.38 5.23 2.17
165 INT54823 Phosphorylation of PTGS1 4 0.51 1.61 2.14
166 INT32557 Negative_regulation of Negative_regulation of PTGS1 8 0.43 3.44 2.1
167 INT15211 Localization of Adra1a 3 0.16 0 2.08
168 INT49253 Regulation of Gene_expression of EDN1 11 0.61 3.92 2.07
169 INT55897 Positive_regulation of C4a 8 0.29 3.81 2.07
170 INT97579 Negative_regulation of Localization of PTGS2 2 0.08 2.37 1.99
171 INT101985 Positive_regulation of Positive_regulation of Ptgs1 4 0.15 4.13 1.98
172 INT10447 Negative_regulation of Srf 3 0.40 0.95 1.98
173 INT45 Negative_regulation of Positive_regulation of Adra1a 4 0.43 0.84 1.97
174 INT49259 Regulation of Localization of EDN1 8 0.61 6.29 1.92
175 INT9076 Regulation of Gene_expression of Tbxa2r 7 0.61 1.16 1.92
176 INT77805 Regulation of Gene_expression of Ptgs2 6 0.51 2.7 1.92
177 INT52691 Positive_regulation of Transcription of Ptgs2 5 0.44 3 1.9
178 INT61806 Regulation of Negative_regulation of Ada 1 0.30 0.63 1.89
179 INT76834 Negative_regulation of Gene_expression of Edn1 4 0.43 1.76 1.88
180 INT126626 Positive_regulation of Rhoa 14 0.69 4.43 1.87
181 INT138439 Positive_regulation of Gene_expression of Sphk1 14 0.48 5.93 1.86
182 INT154816 Negative_regulation of Sphk1 19 0.41 11.38 1.84
183 INT79815 Positive_regulation of Localization of Edn1 7 0.68 2.07 1.79
184 INT53812 Regulation of Gene_expression of Ptgs1 5 0.38 0.89 1.78
185 INT8661 Positive_regulation of Positive_regulation of EDN1 10 0.66 10.9 1.76
186 INT64915 Regulation of Negative_regulation of PTGS1 4 0.20 1.81 1.76
187 INT173700 Negative_regulation of Binding of Edn1 2 0.58 0.41 1.76
188 INT78956 Regulation of Transcription of Ptgs1 3 0.35 1.42 1.7
189 INT14842 Negative_regulation of Binding of EDN1 4 0.57 0.67 1.66
190 INT59077 Transcription of PTGS1 11 0.43 2.37 1.65
191 INT34605 Localization of Ada 7 0.80 0.13 1.61
192 INT60857 Negative_regulation of Regulation of Ptgs1 1 0.07 2.22 1.61
193 INT28210 Negative_regulation of Localization of Tbxa2r 6 0.49 2.09 1.58
194 INT156231 Binding of F2r 9 0.23 3.78 1.57
195 INT29395 Positive_regulation of Gene_expression of Adra1a 2 0.50 1.64 1.57
196 INT199385 Negative_regulation of Gene_expression of Prok2 1 0.43 2.36 1.57
197 INT199387 Binding of Prok2 3 0.37 2.16 1.55
198 INT135574 Positive_regulation of Prok2 2 0.30 0.87 1.54
199 INT181579 Phosphorylation of Edn1 1 0.71 8.59 1.51
200 INT15407 Positive_regulation of Positive_regulation of Edn1 5 0.62 3.69 1.49
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