GO:0046005

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Name positive regulation of circadian sleep/wake cycle, REM sleep
Categary Process
Go Slim No
Go Link GO:0046005
Unique Molecular Interactions 232
Total Molecular Interactions 432
Total Single Events 2427
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of circadian sleep/wake cycle, REM sleep. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of circadian sleep/wake cycle, REM sleep. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2
2 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21
3 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71
4 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08
5 INT11248 Gh Positive_regulation of Ghrh 2 0.26 0.09 4.04
6 INT13729 GHRH Positive_regulation of Localization of GH1 13 0.62 0.59 3.2
7 INT20411 Ghrh Positive_regulation of Gh1 6 0.56 0.62 2.47
8 INT7367 Ghrh Regulation of Localization of Gh1 5 0.49 1.55 2.25
9 INT18197 Ghrh Positive_regulation of Localization of Ggh 4 0.46 0 2.23
10 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18
11 INT120319 Ghrh Regulation of Ngf 1 0.25 1.89 2.11
12 INT35502 Ghrh Positive_regulation of Localization of Gnrhr 7 0.57 0.18 2
13 INT16891 GHRH Regulation of GH1 5 0.37 1.94 1.82
14 INT32482 Ghrh Positive_regulation of Prl 3 0.18 0.26 1.62
15 INT34834 Ghrh Positive_regulation of Gene_expression of Gh1 2 0.65 0 1.4
16 INT32480 Gh1 Positive_regulation of Gene_expression of Ghrh 1 0.35 0 1.15
17 INT32182 PRL Regulation of GHRH 2 0.17 0 1.12
18 INT19887 GHRH Positive_regulation of Positive_regulation of GH1 2 0.56 0.3 1.08
19 INT5106 Gal Positive_regulation of Localization of Ghrh 1 0.21 0 1.07
20 INT120317 Ghrh Regulation of Positive_regulation of Ngf 1 0.25 0.95 1.06
21 INT120311 Ghrh Regulation of Gene_expression of Ngf 1 0.25 0.95 1.06
22 INT120312 Ghrh Regulation of Tnf 1 0.26 0.95 1.05
23 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
24 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 0.43 0.95 1.05
25 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
26 INT35157 GH1 Regulation of GHRH 3 0.17 0.5 0.99
27 INT19758 Ghrh Positive_regulation of Positive_regulation of Gh 1 0.26 0 0.98
28 INT25272 Binding of Ggh and Ghrh 1 0.22 0 0.97
29 INT5108 Gal Positive_regulation of Ghrh 1 0.21 0 0.96
30 INT31108 Ghrh Negative_regulation of Gh1 2 0.55 0 0.95
31 INT62106 Ghrh Negative_regulation of Localization of Gh 1 0.06 0 0.94
32 INT35252 Gene_expression of Ghrh Positive_regulation of Localization of Gh1 1 0.49 0 0.93
33 INT30411 Ghrh Regulation of Gene_expression of Gh1 1 0.40 0.12 0.9
34 INT62111 SLC25A4 Negative_regulation of Regulation of Ghrh 1 0.41 0 0.9
35 INT15730 Ghrh Positive_regulation of Gnrhr 2 0.14 0.08 0.84
36 INT33995 Ghrh Regulation of Gnrhr 2 0.18 0.43 0.77
37 INT31306 Ghrh Regulation of Localization of Gnrhr 2 0.14 1 0.73
38 INT16894 Regulation of GHRH Regulation of GH1 2 0.37 0 0.72
39 INT31307 Ghrh Regulation of Gh1 3 0.27 1.36 0.7
40 INT30125 Binding of Gh and Ghrh 2 0.06 0.36 0.7
41 INT64070 Tp63 Regulation of Ghrh 1 0.04 0.06 0.69
42 INT40470 GH1 Positive_regulation of GHRH 1 0.06 0 0.67
43 INT5105 Gal Regulation of Localization of Ghrh 1 0.19 0 0.66
44 INT62249 Ghrh Regulation of Adrb1 1 0.00 0 0.62
45 INT19011 Binding of Ghrh and Ghsr 1 0.40 0 0.62
46 INT120206 Binding of UTS2R and Il1 1 0.17 1.28 0.59
47 INT120207 Binding of UTS2R and Il1f5 1 0.09 1.28 0.59
48 INT18405 GHRH Positive_regulation of Regulation of SST 1 0.56 0 0.57
49 INT32484 Gnrhr Regulation of GHRH 1 0.01 0 0.55
50 INT69566 Positive_regulation of Ghrh Regulation of Gh 1 0.04 1.66 0.55
51 INT32478 Gh1 Regulation of Gene_expression of Ghrh 1 0.28 0 0.55
52 INT30959 Ghrh Positive_regulation of Localization of SST 1 0.01 0 0.54
53 INT34368 TRH Positive_regulation of GHRH 1 0.23 0.4 0.53
54 INT56671 Negative_regulation of Ghrh Positive_regulation of Gh1 1 0.40 0 0.49
55 INT67984 GHRH Regulation of PRL 1 0.22 0 0.49
56 INT48114 GHRH Positive_regulation of Localization of CGB 1 0.05 0 0.48
57 INT34988 Ghrh Positive_regulation of Calca 1 0.06 0 0.48
58 INT67983 Positive_regulation of HTR1B Positive_regulation of Localization of GHRH 1 0.42 0 0.47
59 INT34990 Calca Positive_regulation of Ghrh 1 0.06 0 0.47
60 INT101001 GHRH Regulation of Localization of INS 1 0.28 0 0.47
61 INT101003 GHRH Regulation of Localization of GGH 1 0.29 0 0.47
62 INT221085 GHRH Positive_regulation of Gene_expression of IGF1 2 0.56 1.47 0.41
63 INT16302 GHRH Regulation of Localization of GH1 1 0.65 0.62 0.4
64 INT62107 Ghrh Negative_regulation of Regulation of Gh 1 0.06 0 0.39
65 INT67553 Ghrh Positive_regulation of Regulation of Gh 1 0.04 0.55 0.39
66 INT138938 Agrp Regulation of Pmch 1 0.35 0.1 0.38
67 INT8331 OPRD1 Regulation of Localization of GHRH 1 0.18 0.18 0.37
68 INT34865 Ghrh Positive_regulation of Gene_expression of Gnrhr 1 0.07 0 0.37
69 INT35363 Binding of GH1 and GHRH 2 0.36 0.94 0.36
70 INT84030 Regulation of Ghrh Positive_regulation of Gh 1 0.18 0 0.35
71 INT54930 Gnrhr Regulation of Gene_expression of Ghrh 1 0.10 0.16 0.34
72 INT31042 Ghrh Positive_regulation of Localization of PLOD1 1 0.08 0 0.32
73 INT31040 Ghrh Positive_regulation of Localization of FSHR 1 0.05 0 0.31
74 INT31043 Ghrh Positive_regulation of PLOD1 1 0.03 0 0.31
75 INT328299 Binding of GHRH and GHS 1 0.07 2.21 0.31
76 INT31041 Ghrh Positive_regulation of FSHR 1 0.05 0 0.31
77 INT26065 GHRH Regulation of Regulation of GH1 1 0.11 0 0.3
78 INT31036 Ghrh Regulation of Gnrh1 1 0.19 0 0.29
79 INT25169 GHRH Positive_regulation of Localization of Gh 1 0.12 0 0.29
80 INT43837 POMC Positive_regulation of GHRH 1 0.16 0 0.28
81 INT43836 Regulation of POMC Positive_regulation of GHRH 1 0.14 0 0.28
82 INT89910 GHRH Positive_regulation of Localization of POMC 1 0.33 0 0.28
83 INT89896 GHRH Positive_regulation of Localization of PRL 1 0.30 0 0.27
84 INT20029 Ghrh Positive_regulation of Negative_regulation of Gh 1 0.05 0.14 0.26
85 INT68872 Ghrh Regulation of IGF1 1 0.09 0.18 0.26
86 INT34784 DIO2 Regulation of Localization of GHRH 1 0.00 0 0.25
87 INT74043 Negative_regulation of Oprd1 Negative_regulation of Localization of GHRH 1 0.02 0 0.25
88 INT34785 DIO2 Positive_regulation of Localization of GHRH 1 0.01 0 0.25
89 INT74044 GHRH Positive_regulation of Localization of Oprd1 1 0.02 0 0.25
90 INT32330 POMC Positive_regulation of Localization of GHRH 1 0.12 0 0.24
91 INT50488 Vip Positive_regulation of Localization of Ghrh 1 0.60 0 0.24
92 INT81252 Uts2r Regulation of Gene_expression of Oprm1 1 0.01 0.07 0.24
93 INT71091 ADCYAP1 Positive_regulation of Localization of GHRH 1 0.26 0.26 0.24
94 INT71090 ADCYAP1 Positive_regulation of GHRH 1 0.12 0.26 0.24
95 INT20030 Negative_regulation of SST Positive_regulation of Ghrh 1 0.01 0.16 0.23
96 INT58243 Ghrh Regulation of Prl 1 0.04 0.18 0.21
97 INT35149 PLOD1 Regulation of GHRH 1 0.02 0 0.21
98 INT32325 DBI Positive_regulation of GHRH 1 0.02 0 0.21
99 INT35153 FSHR Regulation of GHRH 1 0.04 0 0.21
100 INT32331 DBI Positive_regulation of Localization of GHRH 1 0.02 0 0.21
101 INT257398 Binding of FGD1 and GHRH 1 0.03 0.27 0.2
102 INT148995 Uts2 Positive_regulation of CDNF 1 0.00 0.41 0.2
103 INT222509 Ghrh Positive_regulation of Localization of Prl 1 0.28 0.23 0.16
104 INT206212 UTS2R Positive_regulation of CD24 1 0.09 0.71 0.15
105 INT31849 Ghrh Regulation of SST 1 0.09 0 0.14
106 INT31037 Binding of Gnrh1 and Ghrh 1 0.25 0 0.14
107 INT328374 GHRH Positive_regulation of Ghrl 1 0.13 0.26 0.13
108 INT263320 Gsk3b Regulation of Uts2r 1 0.02 0.68 0.13
109 INT276767 NR3C1 Regulation of Gene_expression of UTS2R 1 0.00 1.09 0.13
110 INT29465 NA Regulation of Localization of Ghrh 1 0.01 0 0.13
111 INT203018 GHRH Positive_regulation of Localization of PYY 1 0.01 0.81 0.12
112 INT311399 Binding of Celf1 and Uts2r 1 0.08 0.26 0.12
113 INT50300 Igf1 Positive_regulation of Gene_expression of Ghrh 1 0.26 0 0.11
114 INT328294 GHS Positive_regulation of Localization of GHRH 1 0.10 0.12 0.11
115 INT327704 Uts2r Positive_regulation of 4930579C15Rik 1 0.03 0.48 0.1
116 INT31308 Positive_regulation of Ghrh Regulation of Gh1 1 0.14 0.69 0.1
117 INT350694 Uts2r Negative_regulation of Negative_regulation of Rc3h1 1 0.05 0.79 0.1
118 INT328364 Binding of GHRH and Ghrl 1 0.09 0.2 0.1
119 INT328297 GHRH Positive_regulation of Transcription of GH1 1 0.04 0.26 0.1
120 INT327709 Uts2r Positive_regulation of Comt 1 0.14 0.47 0.1
121 INT42587 EPO Regulation of GHRH 1 0.01 0.19 0.09
122 INT31847 Ghrh Positive_regulation of Positive_regulation of Gh1 1 0.20 0 0.08
123 INT31845 Negative_regulation of Ghrh Positive_regulation of Gh1 1 0.18 0 0.08
124 INT27854 Binding of GHRH and DYM 1 0.01 0 0.07
125 INT54820 Binding of GHRH and SERPINA7 1 0.29 0.52 0.07
126 INT196592 Binding of CFD and GHRH 1 0.02 1.88 0.07
127 INT78445 Binding of GHRH and IGF1 1 0.20 0.72 0.06
128 INT339779 IGF1 Regulation of GHRH 1 0.08 0.38 0.05
129 INT222508 Ghrh Regulation of Localization of LH 1 0.07 0 0.05
130 INT321651 Binding of Slc6a3 and Uts2r 1 0.04 0.06 0.05
131 INT270568 Binding of UTS2R and STAT6 1 0.04 2 0.05
132 INT83235 SST Negative_regulation of Localization of GHRH 1 0.12 0.26 0.05
133 INT317181 Binding of Htt and Uts2r 1 0.04 0 0.05
134 INT321654 Binding of Slc6a4 and Uts2r 1 0.05 0.07 0.05
135 INT327710 Binding of Gopc and Uts2r 1 0.03 0.41 0.04
136 INT222567 Negative_regulation of Gh1 Negative_regulation of Ghrh 1 0.03 0.19 0.04
137 INT222498 Ghrh Positive_regulation of Gene_expression of Ghrl 1 0.10 0.19 0.04
138 INT327711 Binding of Drd2 and Uts2r 1 0.07 0.41 0.04
139 INT221952 UTS2R Regulation of Protein_catabolism of CDK5R1 1 0.10 0.3 0.04
140 INT328303 Gene_expression of GHS Positive_regulation of Gene_expression of GHRH 1 0.09 0.19 0.04
141 INT221953 UTS2R Positive_regulation of Gene_expression of CDK5R1 1 0.16 0.23 0.04
142 INT239605 Ghrh Negative_regulation of Gh 1 0.01 0.53 0.04
143 INT328301 GHRH Positive_regulation of SCG5 1 0.24 0.13 0.04
144 INT328295 GHRH Positive_regulation of GHS 1 0.10 0.13 0.04
145 INT221962 UTS2R Regulation of Gene_expression of CDK5R1 1 0.09 0.43 0.03
146 INT221961 Binding of ELAVL1 and UTS2R 1 0.00 0.26 0.03
147 INT247085 Binding of CRHBP and GHRH 1 0.01 0.2 0.03
148 INT265881 GHRH Positive_regulation of GHR 1 0.05 0.05 0.03
149 INT328298 GHRH Negative_regulation of Localization of GHS 1 0.08 0.84 0
150 INT294922 GH1 Positive_regulation of Gene_expression of GHRH 1 0.02 0.2 0
151 INT72269 Positive_regulation of GHRH Positive_regulation of Gh 1 0.02 0.06 0
152 INT337404 Binding of UTS2R and WG 1 0.01 0.2 0
153 INT343701 Binding of UTS2R and LOC100364739 1 0.00 0 0
154 INT11606 Regulation of Ghrh Regulation of Gh 1 0.06 0.05 0
155 INT101002 GHRH Positive_regulation of Localization of GGH 1 0.30 0 0
156 INT350710 Uts2r Negative_regulation of Gene_expression of MIR21 1 0.01 0 0
157 INT262706 Uts2r Positive_regulation of Bace1 1 0.10 0.39 0
158 INT350707 Uts2r Negative_regulation of Gene_expression of Foxp3 1 0.03 0 0
159 INT51876 CCBE1 Regulation of GHRH 1 0.01 1.07 0
160 INT221442 Binding of UTS2R and CREG1 1 0.01 0.92 0
161 INT328296 GHRH Negative_regulation of Localization of GH1 1 0.03 0.84 0
162 INT327705 Binding of Sugt1 and Uts2r 1 0.00 0.19 0
163 INT17540 Ghsr Regulation of GHRH 1 0.22 0 0
164 INT221957 Binding of UTS2R and GOPC 1 0.02 0.08 0
165 INT237461 Binding of UTS2R and TTPA 1 0.01 0.63 0
166 INT274433 Binding of Zfpm2 and Uts2r 1 0.08 0.17 0
167 INT262700 Uts2r Regulation of Gene_expression of Bace1 1 0.12 0.21 0
168 INT263319 Binding of Gsk3b and Uts2r 1 0.01 0 0
169 INT72268 GHRH Positive_regulation of Gh 1 0.02 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of circadian sleep/wake cycle, REM sleep. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of circadian sleep/wake cycle, REM sleep. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5095 Localization of Ghrh 185 0.81 28.09 62.08
2 INT249 Localization of GHRH 215 0.80 78.02 51.87
3 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52
4 INT5100 Positive_regulation of Ghrh 100 0.64 24.2 30.21
5 INT250 Regulation of GHRH 65 0.61 17.46 23.19
6 INT955 Gene_expression of GHRH 126 0.78 59.91 20.74
7 INT7364 Regulation of Ghrh 49 0.58 8.05 19.05
8 INT9179 Positive_regulation of Localization of Ghrh 42 0.70 7.05 18.1
9 INT984 Positive_regulation of Localization of GHRH 58 0.70 12.66 16.51
10 INT7366 Negative_regulation of Ghrh 42 0.58 7.72 14.45
11 INT16530 Gene_expression of Ghrh 45 0.77 6.22 13.44
12 INT254 Regulation of Localization of GHRH 30 0.60 5.17 11.46
13 INT19010 Negative_regulation of Localization of Ghrh 27 0.57 4.85 10.5
14 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34
15 INT953 Positive_regulation of Positive_regulation of GHRH 17 0.67 2.38 8.18
16 INT7925 Transcription of Ghrh 13 0.67 2.36 6.77
17 INT7361 Binding of Ghrh 13 0.45 1.37 5.44
18 INT9178 Regulation of Localization of Ghrh 13 0.45 2.28 5.08
19 INT19900 Binding of GHRH 22 0.37 5.75 5
20 INT19008 Positive_regulation of Positive_regulation of Ghrh 15 0.49 2.4 4.55
21 INT16304 Negative_regulation of Positive_regulation of GHRH 9 0.51 2.56 4.25
22 INT986 Negative_regulation of Localization of GHRH 16 0.58 8.57 3.16
23 INT20028 Positive_regulation of Gene_expression of Ghrh 9 0.50 1.52 2.62
24 INT16527 Negative_regulation of Positive_regulation of Ghrh 6 0.43 1.01 2.23
25 INT11604 Regulation of Positive_regulation of Ghrh 4 0.42 0.62 2.05
26 INT54929 Negative_regulation of Transcription of Ghrh 4 0.43 0.69 2.04
27 INT16529 Negative_regulation of Gene_expression of Ghrh 6 0.43 0.34 2.02
28 INT954 Positive_regulation of Gene_expression of GHRH 18 0.50 7.6 1.63
29 INT43264 Transcription of GHRH 5 0.59 0.4 1.42
30 INT47102 Regulation of Binding of GHRH 2 0.28 0 1.34
31 INT58421 Positive_regulation of Transcription of GHRH 1 0.43 0.38 1.32
32 INT16854 Gene_expression of Uts2r 17 0.26 3.1 1.31
33 INT8334 Regulation of Positive_regulation of GHRH 3 0.43 0.7 1.27
34 INT25432 Negative_regulation of Gene_expression of GHRH 6 0.37 2.9 1.12
35 INT93296 Gene_expression of Pmch 6 0.64 0.48 1
36 INT13732 Negative_regulation of Regulation of GHRH 3 0.43 0.84 0.93
37 INT51744 Regulation of Uts2 8 0.56 0.23 0.86
38 INT184678 Regulation of Uts2r 7 0.14 2.57 0.85
39 INT244897 Binding of Uts2r 7 0.11 1.8 0.84
40 INT31046 Negative_regulation of Uts2 6 0.42 0.44 0.76
41 INT18406 Regulation of Regulation of GHRH 2 0.45 0.93 0.76
42 INT34944 Protein_catabolism of Ghrh 1 0.73 0 0.76
43 INT34943 Positive_regulation of Protein_catabolism of Ghrh 1 0.41 0 0.76
44 INT19891 Regulation of Gene_expression of GHRH 3 0.43 1.46 0.68
45 INT29460 Regulation of Gene_expression of Ghrh 3 0.31 0.3 0.68
46 INT64981 Regulation of Transcription of Ghrh 1 0.26 0.88 0.67
47 INT101674 Regulation of Regulation of Ghrh 1 0.38 0 0.65
48 INT317151 Transcription of Uts2r 4 0.24 1.16 0.51
49 INT56670 Positive_regulation of Negative_regulation of Ghrh 2 0.49 0.12 0.48
50 INT69423 Positive_regulation of Regulation of Ghrh 1 0.50 0 0.48
51 INT58420 Negative_regulation of Transcription of GHRH 1 0.37 0.13 0.45
52 INT51743 Gene_expression of Uts2 5 0.76 0.3 0.33
53 INT7360 Regulation of Binding of Ghrh 1 0.45 0.18 0.33
54 INT53854 Regulation of Negative_regulation of Uts2 3 0.44 0 0.29
55 INT72536 Phosphorylation of Ghrh 1 0.63 0 0.27
56 INT310382 Positive_regulation of Binding of Uts2r 1 0.03 0.19 0.27
57 INT16219 Negative_regulation of Regulation of Ghrh 1 0.11 0.5 0.27
58 INT317149 Localization of Uts2r 1 0.07 0 0.25
59 INT327694 Positive_regulation of Transcription of Uts2r 1 0.17 0.26 0.21
60 INT27562 Negative_regulation of Negative_regulation of GHRH 1 0.27 0.31 0.18
61 INT27860 Positive_regulation of Phosphorylation of GHRH 1 0.07 0 0.17
62 INT27857 Phosphorylation of GHRH 1 0.11 0 0.16
63 INT208039 Gene_expression of UTS2R 14 0.43 4.95 0.13
64 INT183206 Regulation of UTS2R 5 0.13 3.17 0.12
65 INT33547 Negative_regulation of Negative_regulation of Ghrh 2 0.42 0.62 0.12
66 INT53855 Positive_regulation of Gene_expression of Uts2 1 0.49 0 0.11
67 INT51742 Binding of Uts2 1 0.34 0 0.08
68 INT208046 Positive_regulation of UTS2R 3 0.45 0.7 0.07
69 INT311337 Positive_regulation of Uts2r 3 0.12 1.34 0.05
70 INT183205 Binding of UTS2R 3 0.11 1.33 0.05
71 INT222268 Transcription of UTS2R 2 0.44 0.21 0.05
72 INT222265 Regulation of Transcription of UTS2R 1 0.29 0 0.05
73 INT327271 Negative_regulation of Uts2r 2 0.13 0.42 0.04
74 INT263258 Protein_catabolism of Uts2r 1 0.05 0.47 0.04
75 INT274423 Positive_regulation of Gene_expression of Uts2r 3 0.09 0.58 0
76 INT208049 Regulation of Gene_expression of UTS2R 2 0.16 0.24 0
77 INT265296 Negative_regulation of Gene_expression of UTS2R 1 0.04 0.16 0
78 INT263261 Regulation of Gene_expression of Uts2r 1 0.04 0 0
79 INT208042 Localization of UTS2R 1 0.06 0.45 0
80 INT208041 Positive_regulation of Localization of UTS2R 1 0.04 0.45 0
81 INT141560 Positive_regulation of Uts2 1 0.50 0 0
82 INT39204 Positive_regulation of Negative_regulation of GHRH 1 0.49 0 0
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