GO:0046068

From wiki-pain
Jump to: navigation, search
Name cGMP metabolic process
Categary Process
Go Slim No
Go Link GO:0046068
Unique Molecular Interactions 44
Total Molecular Interactions 50
Total Single Events 466
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cGMP metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for cGMP metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67
2 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
3 INT257304 Pde5a Positive_regulation of Oprd1 1 0.15 0.48 0.89
4 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86
5 INT291581 Pde5a Regulation of Localization of Abat 1 0.03 0 0.83
6 INT257222 Binding of Ltp and Pde5a 2 0.07 0.14 0.75
7 INT257302 Cnp Regulation of Protein_catabolism of Pde5a 1 0.05 0.49 0.7
8 INT197233 Positive_regulation of Rora Positive_regulation of Localization of Helt 1 0.00 0 0.68
9 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6
10 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48
11 INT257229 Binding of PRKG1 and Pde5a 1 0.01 0.17 0.41
12 INT221259 Pde5a Positive_regulation of Localization of PRKG1 1 0.00 0.06 0.37
13 INT275094 Pde5a Regulation of Ltp 1 0.05 0 0.35
14 INT316929 Pde5a Regulation of Ephb1 1 0.03 0.17 0.27
15 INT280181 Pde5a Positive_regulation of Regulation of Cpox 1 0.00 0.16 0.26
16 INT257224 Pde5a Positive_regulation of Phosphorylation of Creb1 1 0.03 0.09 0.2
17 INT202297 Pde5a Positive_regulation of Prkg1 1 0.00 0.13 0.18
18 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
19 INT257221 Negative_regulation of Binding of Src and Pde5a 1 0.03 0 0.08
20 INT257219 Binding of Src and Pde5a 1 0.02 0 0.08
21 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07
22 INT222429 Nps Positive_regulation of Pde5a 1 0.00 0.16 0.07
23 INT337608 Pde5a Regulation of Cnga1 1 0.00 0 0.04
24 INT263197 Binding of PDE3A and Pde5a 1 0.03 0.18 0.04
25 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
26 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
27 INT263198 Pde5a Negative_regulation of PDE4A 1 0.09 0.16 0.03
28 INT331897 Binding of PDE5A and Pde5a 1 0.02 0.64 0.03
29 INT222556 Pde5a Regulation of Localization of LH 1 0.00 0.06 0
30 INT313871 Pde5a Positive_regulation of Pah 1 0.49 0.97 0
31 INT190890 Binding of RORA and Grip1 1 0.00 0.09 0
32 INT240723 Atp2b2 Positive_regulation of Localization of Ca2 1 0.11 0.43 0
33 INT263181 Binding of Pde1a and Pde5a 1 0.03 0 0
34 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
35 INT98236 LOC360919 Positive_regulation of Pde5a 1 0.00 0.33 0
36 INT240724 Atp2b2 Positive_regulation of Ca2 1 0.11 0.54 0
37 INT268021 Pde5a Positive_regulation of Kcnj5 1 0.01 0 0
38 INT263183 Binding of Pde1b and Pde5a 1 0.03 0 0
39 INT268052 Pde5a Positive_regulation of Positive_regulation of PRKG1 1 0.00 0 0
40 INT268022 Pde5a Positive_regulation of Gene_expression of Kcnj5 1 0.01 0 0
41 INT222471 Gnrh1 Positive_regulation of Pde5a 1 0.00 0.07 0
42 INT98235 Pde5a Negative_regulation of Pdpk1 1 0.00 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cGMP metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in cGMP metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65
2 INT209 Positive_regulation of Pde5a 30 0.21 2.54 16.31
3 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27
4 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28
5 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14
6 INT125444 Gene_expression of Rora 5 0.75 3.05 8.97
7 INT94862 Positive_regulation of Gene_expression of Pde5a 10 0.20 4.23 5.18
8 INT73128 Regulation of Pde5a 7 0.37 4.42 4.27
9 INT73127 Gene_expression of Pde5a 18 0.76 5.25 3.31
10 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06
11 INT136675 Transcription of Pde5a 6 0.63 4.74 2.71
12 INT190881 Positive_regulation of Rora 2 0.43 1.76 2.71
13 INT94860 Negative_regulation of Gene_expression of Pde5a 2 0.33 3.2 2.64
14 INT125442 Negative_regulation of Gene_expression of Rora 5 0.57 2.92 2.54
15 INT257298 Regulation of Positive_regulation of Pde5a 1 0.19 2.03 2.54
16 INT257299 Binding of Pde5a 14 0.27 4.31 2.45
17 INT197228 Positive_regulation of Gene_expression of Rora 1 0.05 0 2.43
18 INT257301 Protein_catabolism of Pde5a 5 0.30 1.97 2.26
19 INT108422 Binding of Pde5a 11 0.36 3.07 2.07
20 INT165648 Negative_regulation of Transcription of Pde5a 1 0.41 3.6 1.93
21 INT291576 Positive_regulation of Protein_catabolism of Pde5a 1 0.12 1.15 1.43
22 INT73126 Positive_regulation of Gene_expression of Pde5a 3 0.59 0.55 1.31
23 INT257200 Phosphorylation of Pde5a 1 0.25 0 0.94
24 INT165644 Regulation of Transcription of Pde5a 1 0.44 1.65 0.91
25 INT164144 Phosphorylation of Pde5a 4 0.19 1.15 0.87
26 INT177532 Localization of Pde5a 2 0.56 0.96 0.81
27 INT165645 Positive_regulation of Negative_regulation of Pde5a 3 0.37 1.58 0.74
28 INT197226 Regulation of Gene_expression of Rora 1 0.04 0 0.71
29 INT165647 Negative_regulation of Negative_regulation of Pde5a 1 0.31 1.22 0.67
30 INT257202 Protein_catabolism of Pde5a 2 0.38 0.36 0.66
31 INT165646 Positive_regulation of Transcription of Pde5a 1 0.33 1.21 0.66
32 INT208 Negative_regulation of Positive_regulation of Pde5a 3 0.17 2.02 0.65
33 INT275071 Negative_regulation of Protein_catabolism of Pde5a 1 0.17 0.36 0.6
34 INT167595 Gene_expression of RORA 2 0.05 1.51 0.54
35 INT257211 Negative_regulation of Localization of Pde5a 1 0.13 0.2 0.48
36 INT291577 Positive_regulation of Phosphorylation of Pde5a 1 0.12 0.35 0.48
37 INT197215 Regulation of Regulation of Rora 1 0.03 0.08 0.46
38 INT197227 Regulation of Rora 1 0.06 0.08 0.46
39 INT53282 Negative_regulation of Atp2b2 4 0.15 2.6 0.45
40 INT197214 Binding of Rora 1 0.04 0.09 0.39
41 INT275073 Positive_regulation of Negative_regulation of Pde5a 1 0.22 0.45 0.3
42 INT183429 Localization of Pde5a 5 0.56 1.61 0.25
43 INT261276 Positive_regulation of Positive_regulation of Pde5a 1 0.26 0.07 0.21
44 INT42375 Positive_regulation of Positive_regulation of Pde5a 2 0.14 0.1 0.19
45 INT261275 Negative_regulation of Localization of Pde5a 2 0.31 1.11 0.18
46 INT42376 Regulation of Positive_regulation of Pde5a 1 0.03 0 0.18
47 INT177528 Negative_regulation of Binding of Pde5a 1 0.34 0.46 0.15
48 INT145362 Positive_regulation of RORA 3 0.49 0.61 0.14
49 INT275069 Negative_regulation of Gene_expression of Pde5a 1 0.26 0.54 0.13
50 INT240716 Negative_regulation of Gene_expression of Atp2b2 1 0.09 0.78 0.1
51 INT261274 Negative_regulation of Protein_catabolism of Pde5a 1 0.20 0.18 0.09
52 INT240713 Gene_expression of Atp2b2 1 0.14 1.16 0.09
53 INT125443 Negative_regulation of Rora 1 0.57 0.74 0.08
54 INT257205 Transcription of Pde5a 1 0.21 0 0.08
55 INT240714 Negative_regulation of Localization of Atp2b2 1 0.09 1.3 0.08
56 INT190888 Positive_regulation of Phosphorylation of RORA 1 0.01 0.25 0.06
57 INT190886 Phosphorylation of RORA 1 0.01 0.25 0.06
58 INT183435 Regulation of Localization of Pde5a 1 0.34 0.35 0.04
59 INT323262 Negative_regulation of Negative_regulation of Pde5a 1 0.03 1.32 0.04
60 INT240715 Localization of Atp2b2 1 0.16 1.07 0.04
61 INT263185 Regulation of Gene_expression of Pde5a 1 0.12 0.19 0.03
62 INT50097 Regulation of RORA 2 0.01 0 0
63 INT268038 Regulation of Negative_regulation of Pde5a 1 0.03 0 0
64 INT50098 Negative_regulation of RORA 1 0.02 0 0
65 INT190887 Binding of RORA 1 0.00 0.1 0
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox