GO:0046069

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Name cGMP catabolic process
Categary Process
Go Slim No
Go Link GO:0046069
Unique Molecular Interactions 154
Total Molecular Interactions 191
Total Single Events 1468
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for cGMP catabolic process. They are ordered first by their pain relevance and then by number of times they were reported for cGMP catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67
2 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
3 INT14197 Pde2a Positive_regulation of Localization of Gh1 2 0.04 0 1.08
4 INT257304 Pde5a Positive_regulation of Oprd1 1 0.15 0.48 0.89
5 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86
6 INT291581 Pde5a Regulation of Localization of Abat 1 0.03 0 0.83
7 INT257222 Binding of Ltp and Pde5a 2 0.07 0.14 0.75
8 INT257302 Cnp Regulation of Protein_catabolism of Pde5a 1 0.05 0.49 0.7
9 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6
10 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48
11 INT86972 PDE1B Positive_regulation of Localization of Gh 1 0.00 0 0.42
12 INT275087 Pde2a Negative_regulation of stm 1 0.01 0.51 0.42
13 INT275104 Pde2a Negative_regulation of RTP3 1 0.00 0.51 0.42
14 INT257229 Binding of PRKG1 and Pde5a 1 0.01 0.17 0.41
15 INT221259 Pde5a Positive_regulation of Localization of PRKG1 1 0.00 0.06 0.37
16 INT275094 Pde5a Regulation of Ltp 1 0.05 0 0.35
17 INT79383 Pde1b Regulation of Oprd1 1 0.02 0 0.34
18 INT316929 Pde5a Regulation of Ephb1 1 0.03 0.17 0.27
19 INT280181 Pde5a Positive_regulation of Regulation of Cpox 1 0.00 0.16 0.26
20 INT235125 PDE2A Negative_regulation of Twist1 1 0.00 0.99 0.24
21 INT257224 Pde5a Positive_regulation of Phosphorylation of Creb1 1 0.03 0.09 0.2
22 INT163055 Negative_regulation of Pde10a Positive_regulation of Gene_expression of Qrfp 1 0.03 0 0.2
23 INT32162 POMC Negative_regulation of PDE11A 1 0.23 0 0.19
24 INT196822 Negative_regulation of Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
25 INT196815 Adcy5 Positive_regulation of Pde1a 1 0.01 0 0.19
26 INT202297 Pde5a Positive_regulation of Prkg1 1 0.00 0.13 0.18
27 INT276065 Camk2a Negative_regulation of Pde1b 1 0.56 0 0.17
28 INT263180 Binding of PDE5A and COPD 1 0.01 1 0.15
29 INT276060 Pde1b Regulation of Car2 1 0.30 0 0.15
30 INT263175 PDE5A Regulation of COPD 1 0.00 1 0.15
31 INT87110 Apom Negative_regulation of Pde1a 1 0.00 0 0.15
32 INT273017 Binding of PDE1B and PDE11A 1 0.08 0.35 0.14
33 INT196811 Binding of Pde1a and Adcy5 1 0.01 0 0.14
34 INT196837 Binding of CALM1 and Pde1a 1 0.00 0 0.14
35 INT135941 Positive_regulation of PDE2A Positive_regulation of Gene_expression of PRKG1 1 0.13 0.8 0.13
36 INT276079 Pde1b Negative_regulation of Camk2a 1 0.41 0 0.12
37 INT273020 Binding of FGF9 and PDE11A 1 0.22 0.3 0.11
38 INT135943 Positive_regulation of PRKG1 Regulation of PDE2A 1 0.08 0.73 0.1
39 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
40 INT148096 Vasp Regulation of Pde2a 1 0.00 0.23 0.08
41 INT257221 Negative_regulation of Binding of Src and Pde5a 1 0.03 0 0.08
42 INT98269 PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
43 INT257219 Binding of Src and Pde5a 1 0.02 0 0.08
44 INT98270 Positive_regulation of PDE2A Positive_regulation of PRKG1 1 0.07 0.57 0.08
45 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07
46 INT222429 Nps Positive_regulation of Pde5a 1 0.00 0.16 0.07
47 INT276067 Binding of Car2 and Pde1b 1 0.32 0 0.06
48 INT276050 Binding of Calm3 and Pde1b 1 0.15 0 0.06
49 INT276049 Pde1b Regulation of Positive_regulation of Rpa1 1 0.04 0 0.06
50 INT337608 Pde5a Regulation of Cnga1 1 0.00 0 0.04
51 INT263197 Binding of PDE3A and Pde5a 1 0.03 0.18 0.04
52 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
53 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
54 INT276038 Camk2a Negative_regulation of Pde1a 1 0.14 0 0.03
55 INT263198 Pde5a Negative_regulation of PDE4A 1 0.09 0.16 0.03
56 INT276036 Negative_regulation of Pde1b Positive_regulation of Phosphorylation of Prkaca 1 0.27 0 0.03
57 INT325600 Nppa Positive_regulation of Pde2a 1 0.11 0.16 0.03
58 INT331897 Binding of PDE5A and Pde5a 1 0.02 0.64 0.03
59 INT276055 Negative_regulation of Pde1b Positive_regulation of Prkaca 1 0.27 0 0.03
60 INT276070 Negative_regulation of Pde1b Positive_regulation of Phosphorylation of Ppp1r1b 1 0.24 0 0.03
61 INT308425 Binding of Pde2a and Aip 1 0.04 1.37 0
62 INT325602 Binding of Ang and Pde2a 1 0.07 0.15 0
63 INT276044 Binding of Pde1b and Ppp1cc 1 0.12 0 0
64 INT222556 Pde5a Regulation of Localization of LH 1 0.00 0.06 0
65 INT313871 Pde5a Positive_regulation of Pah 1 0.49 0.97 0
66 INT276048 Binding of Pde1b and Myoz1 1 0.04 0 0
67 INT209159 Binding of LHCGR and PDE5A 1 0.01 0 0
68 INT186239 Binding of ROS1 and Positive_regulation of PDE2A 1 0.00 0 0
69 INT276078 Binding of Camk2a and Pde1b 1 0.36 0 0
70 INT263182 Ca2 Positive_regulation of Phosphorylation of Pde1b 1 0.01 0 0
71 INT276052 Negative_regulation of Pde1b Negative_regulation of Camk2a 1 0.41 0 0
72 INT186241 Gene_expression of ROS1 Positive_regulation of PDE2A 1 0.00 0 0
73 INT325603 Pde2a Regulation of Rgs2 1 0.03 0 0
74 INT263181 Binding of Pde1a and Pde5a 1 0.03 0 0
75 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
76 INT325613 Pls1 Regulation of Pde2a 1 0.00 0 0
77 INT276058 Camk2a Regulation of Pde1b 1 0.26 0 0
78 INT98236 LOC360919 Positive_regulation of Pde5a 1 0.00 0.33 0
79 INT325593 Pde2a Positive_regulation of Negative_regulation of Nppa 1 0.11 0 0
80 INT66168 Pde2a Negative_regulation of Adra2a 1 0.04 0 0
81 INT268021 Pde5a Positive_regulation of Kcnj5 1 0.01 0 0
82 INT263183 Binding of Pde1b and Pde5a 1 0.03 0 0
83 INT276042 Negative_regulation of Binding of Calm3 and Pde1b 1 0.17 0 0
84 INT325612 Rgs2 Regulation of Pde2a 1 0.10 0 0
85 INT268052 Pde5a Positive_regulation of Positive_regulation of PRKG1 1 0.00 0 0
86 INT325609 Pde2a Positive_regulation of Gene_expression of Rgs2 1 0.12 0 0
87 INT268022 Pde5a Positive_regulation of Gene_expression of Kcnj5 1 0.01 0 0
88 INT276047 Camk2a Regulation of Negative_regulation of Pde1b 1 0.43 0 0
89 INT276051 Pde1b Regulation of Regulation of Car2 1 0.30 0 0
90 INT276071 Pde1b Regulation of Positive_regulation of Camk2a 1 0.43 0 0
91 INT222471 Gnrh1 Positive_regulation of Pde5a 1 0.00 0.07 0
92 INT98235 Pde5a Negative_regulation of Pdpk1 1 0.00 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for cGMP catabolic process. They are ordered first by their pain relevance and then by number of times they were reported in cGMP catabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09
2 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65
3 INT209 Positive_regulation of Pde5a 30 0.21 2.54 16.31
4 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27
5 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28
6 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14
7 INT160168 Gene_expression of Pde10a 10 0.74 8.66 7.94
8 INT188852 Gene_expression of Pde2a 13 0.19 6.44 5.35
9 INT94862 Positive_regulation of Gene_expression of Pde5a 10 0.20 4.23 5.18
10 INT73128 Regulation of Pde5a 7 0.37 4.42 4.27
11 INT73127 Gene_expression of Pde5a 18 0.76 5.25 3.31
12 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15
13 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06
14 INT19235 Negative_regulation of PDE1B 11 0.14 2.38 2.81
15 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77
16 INT136675 Transcription of Pde5a 6 0.63 4.74 2.71
17 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7
18 INT94860 Negative_regulation of Gene_expression of Pde5a 2 0.33 3.2 2.64
19 INT257298 Regulation of Positive_regulation of Pde5a 1 0.19 2.03 2.54
20 INT257299 Binding of Pde5a 14 0.27 4.31 2.45
21 INT257301 Protein_catabolism of Pde5a 5 0.30 1.97 2.26
22 INT36642 Negative_regulation of Pde1a 4 0.43 0.89 2.15
23 INT108422 Binding of Pde5a 11 0.36 3.07 2.07
24 INT165648 Negative_regulation of Transcription of Pde5a 1 0.41 3.6 1.93
25 INT24909 Negative_regulation of Pde10a 4 0.43 0.87 1.87
26 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81
27 INT12781 Regulation of Pde2a 4 0.23 1.14 1.69
28 INT64529 Localization of Pde2a 1 0.59 0 1.63
29 INT1580 Negative_regulation of Pde2a 7 0.52 3.26 1.59
30 INT188855 Positive_regulation of Gene_expression of Pde2a 5 0.12 1.97 1.53
31 INT291576 Positive_regulation of Protein_catabolism of Pde5a 1 0.12 1.15 1.43
32 INT68451 Localization of Pde1b 4 0.22 0 1.35
33 INT14195 Localization of Pde2a 4 0.16 0.34 1.33
34 INT73126 Positive_regulation of Gene_expression of Pde5a 3 0.59 0.55 1.31
35 INT242945 Localization of PDE5A 9 0.75 4.57 1.28
36 INT64562 Positive_regulation of Pde1a 2 0.06 0.28 1.28
37 INT73011 Gene_expression of Pde1b 3 0.23 0.38 1.27
38 INT67852 Negative_regulation of Pde1a 1 0.25 0.18 1.2
39 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17
40 INT110400 Negative_regulation of Pde1b 21 0.50 0.58 1.14
41 INT103043 Binding of PDE5A 16 0.37 7.79 1.12
42 INT7834 Gene_expression of Pde2a 5 0.51 1.9 1.01
43 INT69302 Positive_regulation of Pde1b 3 0.21 0.99 0.97
44 INT160171 Localization of Pde10a 2 0.77 1.26 0.95
45 INT188851 Regulation of Gene_expression of Pde2a 1 0.04 0.75 0.94
46 INT257200 Phosphorylation of Pde5a 1 0.25 0 0.94
47 INT165644 Regulation of Transcription of Pde5a 1 0.44 1.65 0.91
48 INT164144 Phosphorylation of Pde5a 4 0.19 1.15 0.87
49 INT89776 Positive_regulation of Pde2a 2 0.47 2.84 0.81
50 INT177532 Localization of Pde5a 2 0.56 0.96 0.81
51 INT98275 Negative_regulation of PDE2A 4 0.17 3.96 0.79
52 INT165645 Positive_regulation of Negative_regulation of Pde5a 3 0.37 1.58 0.74
53 INT183161 Regulation of Pde2a 2 0.05 0.5 0.67
54 INT165647 Negative_regulation of Negative_regulation of Pde5a 1 0.31 1.22 0.67
55 INT257202 Protein_catabolism of Pde5a 2 0.38 0.36 0.66
56 INT165646 Positive_regulation of Transcription of Pde5a 1 0.33 1.21 0.66
57 INT208 Negative_regulation of Positive_regulation of Pde5a 3 0.17 2.02 0.65
58 INT86971 Localization of PDE1B 4 0.15 0.08 0.6
59 INT275071 Negative_regulation of Protein_catabolism of Pde5a 1 0.17 0.36 0.6
60 INT242944 Negative_regulation of Localization of PDE5A 3 0.35 3.18 0.59
61 INT75814 Regulation of Positive_regulation of PDE2A 1 0.23 0.26 0.56
62 INT257211 Negative_regulation of Localization of Pde5a 1 0.13 0.2 0.48
63 INT291577 Positive_regulation of Phosphorylation of Pde5a 1 0.12 0.35 0.48
64 INT130371 Negative_regulation of Gene_expression of PDE5A 3 0.43 1.59 0.45
65 INT162903 Localization of PDE2A 2 0.61 0.89 0.45
66 INT216759 Binding of PDE2A 1 0.00 0.08 0.44
67 INT86970 Positive_regulation of Localization of PDE1B 1 0.00 0 0.42
68 INT79597 Positive_regulation of Negative_regulation of PDE5A 5 0.50 3.39 0.41
69 INT130372 Transcription of PDE5A 7 0.72 1.93 0.4
70 INT79599 Protein_catabolism of PDE5A 7 1.00 3.16 0.39
71 INT79379 Regulation of Pde1b 1 0.07 0 0.37
72 INT235122 Negative_regulation of Positive_regulation of PDE2A 1 0.01 0.72 0.35
73 INT235113 Positive_regulation of Negative_regulation of PDE2A 1 0.01 0.72 0.35
74 INT135945 Positive_regulation of Positive_regulation of PDE2A 2 0.12 0.78 0.34
75 INT242948 Gene_expression of PDE1B 1 0.02 0.91 0.34
76 INT276012 Gene_expression of Pde1b 8 0.66 0.58 0.32
77 INT276027 Positive_regulation of Pde1b 7 0.59 0.71 0.32
78 INT275073 Positive_regulation of Negative_regulation of Pde5a 1 0.22 0.45 0.3
79 INT117995 Regulation of Negative_regulation of PDE5A 3 0.44 2.4 0.29
80 INT273021 Binding of PDE11A 1 0.35 0.78 0.26
81 INT183429 Localization of Pde5a 5 0.56 1.61 0.25
82 INT303483 Positive_regulation of PDE5A 2 0.39 1.5 0.23
83 INT100251 Regulation of PDE1B 4 0.26 1.21 0.22
84 INT261276 Positive_regulation of Positive_regulation of Pde5a 1 0.26 0.07 0.21
85 INT42375 Positive_regulation of Positive_regulation of Pde5a 2 0.14 0.1 0.19
86 INT32164 Positive_regulation of PDE11A 1 0.26 0 0.19
87 INT261275 Negative_regulation of Localization of Pde5a 2 0.31 1.11 0.18
88 INT166869 Positive_regulation of Pde1a 2 0.59 0.74 0.18
89 INT42376 Regulation of Positive_regulation of Pde5a 1 0.03 0 0.18
90 INT163053 Regulation of Negative_regulation of Pde10a 1 0.45 0 0.18
91 INT98276 Regulation of PDE2A 2 0.07 1.54 0.17
92 INT242946 Positive_regulation of Phosphorylation of PDE1B 1 0.01 0.22 0.17
93 INT275085 Transcription of PDE1B 1 0.04 0.27 0.16
94 INT213222 Negative_regulation of Protein_catabolism of PDE5A 1 0.24 0.65 0.16
95 INT177528 Negative_regulation of Binding of Pde5a 1 0.34 0.46 0.15
96 INT263121 Negative_regulation of Negative_regulation of PDE5A 2 0.43 1.33 0.14
97 INT242949 Phosphorylation of PDE5A 2 0.68 0.05 0.13
98 INT275069 Negative_regulation of Gene_expression of Pde5a 1 0.26 0.54 0.13
99 INT84749 Gene_expression of PDE2A 3 0.73 0.84 0.12
100 INT135946 Positive_regulation of Gene_expression of PDE2A 1 0.12 0.77 0.12
101 INT179449 Binding of PDE1B 5 0.07 0.3 0.11
102 INT196773 Negative_regulation of Positive_regulation of Pde1a 1 0.01 0 0.11
103 INT273022 Negative_regulation of PDE11A 1 0.40 0.24 0.11
104 INT135944 Regulation of Regulation of PDE2A 1 0.07 0.73 0.1
105 INT303482 Positive_regulation of Protein_catabolism of PDE5A 1 0.20 1.27 0.1
106 INT261274 Negative_regulation of Protein_catabolism of Pde5a 1 0.20 0.18 0.09
107 INT80630 Protein_catabolism of PDE2A 2 0.19 0.91 0.08
108 INT242947 Phosphorylation of PDE1B 1 0.02 0.11 0.08
109 INT257205 Transcription of Pde5a 1 0.21 0 0.08
110 INT100247 Positive_regulation of PDE1B 2 0.40 0.65 0.07
111 INT111440 Negative_regulation of Gene_expression of Pde2a 1 0.20 1.14 0.07
112 INT276000 Negative_regulation of Positive_regulation of Pde1b 2 0.36 0.54 0.06
113 INT275994 Positive_regulation of Negative_regulation of Pde1b 1 0.43 0 0.06
114 INT183439 Protein_catabolism of Pde2a 1 0.14 0.84 0.05
115 INT183425 Negative_regulation of Protein_catabolism of Pde2a 1 0.09 0.84 0.05
116 INT213216 Positive_regulation of Gene_expression of PDE5A 2 0.37 2.08 0.04
117 INT183435 Regulation of Localization of Pde5a 1 0.34 0.35 0.04
118 INT183437 Regulation of Pde10a 1 0.05 0.4 0.04
119 INT183433 Regulation of Localization of Pde2a 1 0.09 0.34 0.04
120 INT19234 Positive_regulation of Negative_regulation of PDE1B 1 0.01 0.05 0.04
121 INT323262 Negative_regulation of Negative_regulation of Pde5a 1 0.03 1.32 0.04
122 INT183438 Regulation of Localization of Pde10a 1 0.08 0.4 0.04
123 INT275993 Negative_regulation of Gene_expression of Pde1b 2 0.36 0.53 0.03
124 INT276029 Regulation of Negative_regulation of Pde1b 1 0.38 0 0.03
125 INT276013 Phosphorylation of Pde1a 1 0.18 0 0.03
126 INT263185 Regulation of Gene_expression of Pde5a 1 0.12 0.19 0.03
127 INT275998 Positive_regulation of Gene_expression of Pde1b 1 0.43 0 0.03
128 INT263191 Gene_expression of Pde1a 7 0.21 0.33 0
129 INT269744 Negative_regulation of Binding of PDE5A 2 0.43 0.74 0
130 INT162907 Regulation of Gene_expression of PDE5A 2 0.51 0 0
131 INT269741 Positive_regulation of Localization of PDE5A 1 0.04 0.65 0
132 INT268038 Regulation of Negative_regulation of Pde5a 1 0.03 0 0
133 INT100252 Regulation of Regulation of PDE1B 1 0.26 0.55 0
134 INT162918 Transcription of PDE2A 1 0.65 0 0
135 INT276008 Negative_regulation of Localization of Pde1b 1 0.36 0 0
136 INT162909 Gene_expression of PDE11A 1 0.17 0 0
137 INT276007 Negative_regulation of Phosphorylation of Pde1b 1 0.36 0 0
138 INT276001 Positive_regulation of Phosphorylation of Pde1b 1 0.40 0 0
139 INT162902 Positive_regulation of Protein_catabolism of PDE1B 1 0.11 0 0
140 INT162914 Regulation of Localization of PDE2A 1 0.37 0 0
141 INT276006 Phosphorylation of Pde1b 1 0.70 0 0
142 INT275991 Regulation of Phosphorylation of Pde1b 1 0.38 0 0
143 INT162908 Protein_catabolism of PDE1B 1 0.19 0 0
144 INT276011 Localization of Pde1b 1 0.64 0 0
145 INT162922 Negative_regulation of Transcription of PDE5A 1 0.41 0 0
146 INT92876 Regulation of Protein_catabolism of PDE5A 1 0.45 0.71 0
147 INT162912 Regulation of Transcription of PDE5A 1 0.44 0 0
148 INT162916 Negative_regulation of Transcription of PDE2A 1 0.40 0 0
149 INT276023 Positive_regulation of Positive_regulation of Pde1b 1 0.43 0 0
150 INT183430 Binding of Pde2a 1 0.07 0 0
151 INT275999 Binding of Pde1b 1 0.32 0 0
152 INT325558 Negative_regulation of Gene_expression of Pde2a 1 0.11 0.38 0
153 INT162915 Positive_regulation of Regulation of PDE5A 1 0.40 0 0
154 INT263186 Phosphorylation of Pde1b 1 0.24 0 0
155 INT80629 Negative_regulation of Protein_catabolism of PDE2A 1 0.12 0.18 0
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