GO:0046209

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Name nitric oxide metabolic process
Categary Process
Go Slim No
Go Link GO:0046209
Unique Molecular Interactions 348
Total Molecular Interactions 530
Total Single Events 2969
Pain Genes Associated 14

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for nitric oxide metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for nitric oxide metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
3 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
4 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
5 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61
6 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
7 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
8 INT97013 Negative_regulation of Binding of CALM3 and OPRM1 1 0.40 0 1.05
9 INT97011 Binding of CALM3 and OPRM1 1 0.35 0 1.05
10 INT103933 Cps1 Negative_regulation of Gene_expression of Cd69 1 0.03 0.25 0.93
11 INT103930 Cps1 Negative_regulation of Gene_expression of Il2ra 1 0.02 0.25 0.93
12 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89
13 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
14 INT322266 Binding of LIG4 and NOS3 1 0.02 2.35 0.82
15 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79
16 INT258798 Binding of NR3C1 and HSP90AA1 1 0.01 1.09 0.78
17 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
18 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
19 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
20 INT237907 Tlr4 Positive_regulation of Gene_expression of Tlr2 7 0.40 5.85 0.6
21 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
22 INT160780 Cps1 Positive_regulation of Positive_regulation of FAS 1 0.01 1 0.55
23 INT278228 Binding of MBNL1 and NOS3 1 0.05 2.06 0.54
24 INT160779 Cps1 Positive_regulation of ATM 1 0.01 0.94 0.53
25 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
26 INT103937 Cps1 Negative_regulation of Gene_expression of Cd28 1 0.03 0.19 0.51
27 INT103932 Cps1 Negative_regulation of Gene_expression of Trav6-3 1 0.01 0.19 0.5
28 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
29 INT179507 Tlr4 Positive_regulation of Tlr2 2 0.17 1.07 0.49
30 INT103934 Cps1 Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.2 0.49
31 INT352892 Binding of CAV1 and ITGA2 1 0.20 1.61 0.47
32 INT103929 Cps1 Negative_regulation of Gene_expression of Icam1 1 0.01 0.13 0.47
33 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
34 INT246938 Binding of Tlr4 and Tlr2 3 0.39 2.88 0.46
35 INT103936 Cps1 Negative_regulation of Il2ra 1 0.02 0.07 0.46
36 INT103931 Cps1 Negative_regulation of Icam1 1 0.01 0.07 0.46
37 INT103935 Cps1 Negative_regulation of Cd69 1 0.03 0.07 0.46
38 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
39 INT69637 Binding of CAV1 and Zfp354a 1 0.00 0 0.46
40 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
41 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
42 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
43 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
44 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
45 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
46 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
47 INT260744 Binding of Ecm1 and Tlr2 1 0.00 0.45 0.39
48 INT260747 Binding of TLR4 and Tlr2 1 0.05 0.44 0.38
49 INT261058 Binding of CALM3 and CHR 1 0.04 0.14 0.38
50 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
51 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
52 INT80444 Binding of EDNRA and SPR 1 0.05 0.1 0.36
53 INT278226 Binding of FOSB and NOS3 1 0.03 1.22 0.36
54 INT174699 Binding of Tlr2 and Tlr3 3 0.14 0.66 0.35
55 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
56 INT310765 Binding of Pam and Tlr2 1 0.01 0.57 0.35
57 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
58 INT279705 CALM3 Regulation of TRPV4 2 0.08 0 0.33
59 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
60 INT224681 Tlr2 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33
61 INT337410 AKT3 Negative_regulation of AKT1 1 0.09 0.49 0.32
62 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
63 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3
64 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
65 INT224131 Binding of CAV1 and Agtr1a 1 0.00 0.08 0.3
66 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
67 INT261056 Binding of CALM3 and PLA2G6 1 0.09 0 0.27
68 INT261045 Negative_regulation of Binding of CALM3 and PLA2G6 1 0.10 0 0.27
69 INT276953 Positive_regulation of Tlr2 Positive_regulation of Phosphorylation of Stat3 1 0.38 0.93 0.27
70 INT276979 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Stat3 1 0.38 0.93 0.27
71 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
72 INT130056 PPARG Positive_regulation of CAV1 1 0.02 0.53 0.25
73 INT261052 CALM3 Regulation of VIP 1 0.00 0.06 0.25
74 INT246576 EEF1A2 Negative_regulation of Negative_regulation of NOSTRIN 1 0.04 0.63 0.24
75 INT276974 Tlr2 Positive_regulation of Gene_expression of Ccr8 1 0.27 0.16 0.24
76 INT171126 Lta Positive_regulation of NOSTRIN 1 0.01 0.76 0.24
77 INT171124 Spg7 Positive_regulation of NOSTRIN 1 0.01 0.76 0.24
78 INT276952 Tlr2 Positive_regulation of Localization of Hspd1 1 0.25 0.16 0.24
79 INT325008 TNF Negative_regulation of Gene_expression of NOSTRIN 1 0.00 1.78 0.23
80 INT325007 TNF Negative_regulation of NOSTRIN 1 0.00 1.78 0.23
81 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
82 INT281901 Binding of KNG1 and NOS3 1 0.05 0.17 0.22
83 INT309729 CALM3 Regulation of TRPV1 1 0.04 0 0.22
84 INT7332 CALM3 Positive_regulation of ADCY1 1 0.46 0.13 0.21
85 INT266380 Binding of Tlr2 and Il1 1 0.01 0.76 0.21
86 INT163096 Tlr2 Positive_regulation of Gene_expression of VEGFA 1 0.07 0.16 0.21
87 INT120716 Binding of AKT1 and TEP1 1 0.05 0.46 0.21
88 INT254219 Binding of Myd88 and Tlr2 2 0.16 0.6 0.2
89 INT348032 Fndc3b Positive_regulation of Tlr2 1 0.01 1.3 0.2
90 INT258289 Hmgb1 Positive_regulation of Tlr2 4 0.48 3.61 0.19
91 INT175908 Binding of NOS3 and ROS1 1 0.10 1.84 0.19
92 INT339503 Tlr2 Positive_regulation of Eif2ak2 1 0.12 0.09 0.19
93 INT137417 MAPK7 Regulation of Gene_expression of NOS3 1 0.00 0.5 0.19
94 INT298192 EGFR Positive_regulation of AKT1 1 0.10 0.65 0.18
95 INT121582 AKT1 Regulation of Gene_expression of GDF15 1 0.21 0.4 0.18
96 INT318324 Binding of AKT1 and PRKCA 1 0.03 0.63 0.18
97 INT276946 Hspd1 Positive_regulation of Tlr2 2 0.37 1.01 0.17
98 INT176133 AKT1 Regulation of BCL2 2 0.12 1.84 0.17
99 INT105334 PTGER1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.66 0.17
100 INT324820 Hsp90b1 Positive_regulation of Tlr2 1 0.16 0.42 0.17
101 INT176134 AKT1 Regulation of Gene_expression of BIRC3 1 0.08 1.09 0.17
102 INT269333 Binding of BDKRB2 and NOS3 1 0.02 0 0.17
103 INT331768 Binding of Arg1 and NOSTRIN 1 0.01 0.6 0.17
104 INT178079 EDN1 Positive_regulation of Positive_regulation of AKT1 1 0.05 0.91 0.16
105 INT204789 Binding of Tlr2 and Nod2 1 0.23 0.44 0.16
106 INT276958 Binding of Tlr2 and Clec7a 1 0.09 0.58 0.15
107 INT228216 Positive_regulation of Mapk14 Regulation of Gene_expression of Tlr2 1 0.09 1.11 0.15
108 INT155644 Binding of CAV1 and HSD11B1 1 0.39 0.77 0.15
109 INT324874 Positive_regulation of Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
110 INT324860 Tlr2 Positive_regulation of Gene_expression of Mif 1 0.05 0.66 0.15
111 INT276948 Tlr2 Negative_regulation of Gene_expression of Tlr4 1 0.25 1.06 0.14
112 INT261055 Negative_regulation of Binding of CALM3 and CHR 1 0.04 0 0.14
113 INT249829 CHI3L1 Positive_regulation of AKT1 1 0.47 0.69 0.14
114 INT333270 Tlr2 Positive_regulation of Localization of Ccl20 1 0.24 0.16 0.14
115 INT298639 GDE1 Negative_regulation of AKT1 1 0.00 1.14 0.14
116 INT348040 TNF Positive_regulation of Gene_expression of Tlr2 1 0.02 0.98 0.14
117 INT309743 Binding of CA2 and CALM3 1 0.04 0 0.13
118 INT309747 CALM3 Regulation of TRPV5 1 0.03 0 0.13
119 INT309742 CALM3 Regulation of TRPV3 1 0.04 0 0.13
120 INT276950 Hspd1 Positive_regulation of Positive_regulation of Tlr2 1 0.22 1.25 0.13
121 INT302156 AKT1 Positive_regulation of E2F2 1 0.02 0.88 0.13
122 INT309733 CALM3 Regulation of TRPV6 1 0.01 0 0.13
123 INT299310 RPTOR Positive_regulation of AKT1 1 0.30 0 0.12
124 INT345280 Binding of Tlr2 and Tlr7 1 0.05 0.49 0.12
125 INT324691 Tlr6 Positive_regulation of Rcvrn 1 0.01 0 0.12
126 INT269332 Binding of NOS3 and TMPO 1 0.01 0 0.12
127 INT324695 Tlr6 Positive_regulation of Tlr2 1 0.14 0 0.12
128 INT105338 Prkaca Positive_regulation of AKT1 1 0.04 0.93 0.11
129 INT302161 AKT1 Negative_regulation of CASP9 1 0.03 0.87 0.11
130 INT176130 AKT1 Regulation of Gene_expression of COX18 1 0.13 0.82 0.11
131 INT281905 Binding of AGTR2 and NOS3 1 0.08 0.37 0.1
132 INT184814 NOS3 Positive_regulation of Gene_expression of NOS1 1 0.09 0.54 0.1
133 INT343858 Binding of AKT1 and MYD88 1 0.02 0.26 0.1
134 INT281899 Binding of ANG and NOS3 1 0.12 0.37 0.1
135 INT252790 Binding of NOS1 and NOS3 1 0.03 0.37 0.1
136 INT309725 Gene_expression of CALM3 Negative_regulation of Positive_regulation of TRPC6 1 0.07 0 0.1
137 INT276966 Tlr2 Negative_regulation of Gene_expression of Mcpt1 1 0.09 1.38 0.1
138 INT192249 Angpt1 Positive_regulation of Localization of NOS3 1 0.01 0.46 0.09
139 INT175325 Binding of TLR2 and Tlr6 1 0.00 0.39 0.09
140 INT230857 Negative_regulation of Binding of HSP90AA1 and NOS1 1 0.05 1.18 0.09
141 INT252803 Binding of NOS3 and ISYNA1 1 0.02 0.32 0.09
142 INT192248 Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
143 INT192250 Positive_regulation of Angpt1 Positive_regulation of NOS3 1 0.01 0.46 0.09
144 INT230856 Binding of HSP90AA1 and NOS1 1 0.04 1.17 0.09
145 INT309738 CALM3 Positive_regulation of CA2 1 0.04 0 0.08
146 INT288210 Regulation of Tlr2 Positive_regulation of Akt1 1 0.03 0.09 0.08
147 INT288206 Tlr2 Positive_regulation of Akt1 1 0.04 0.09 0.08
148 INT276987 Tlr2 Negative_regulation of Gene_expression of Il10 1 0.15 0.19 0.08
149 INT309737 Binding of CALM3 and Positive_regulation of CA2 1 0.04 0 0.08
150 INT324871 Ros1 Positive_regulation of Gene_expression of Tlr2 1 0.03 1.12 0.07
151 INT309941 Edn1 Positive_regulation of Tlr2 1 0.02 1.31 0.07
152 INT265882 IGF1 Positive_regulation of Transcription of AKT1 1 0.08 1.13 0.07
153 INT276980 Binding of Tlr2 and Gopc 1 0.14 0.28 0.07
154 INT294638 Bcl2a1a Positive_regulation of Tlr2 1 0.58 0.43 0.07
155 INT181645 Edn1 Positive_regulation of NOS3 1 0.02 0.21 0.07
156 INT275105 CALM3 Positive_regulation of Prkcg 1 0.00 0 0.06
157 INT309748 CALM3 Regulation of CA2 1 0.02 0 0.06
158 INT309732 CALM3 Positive_regulation of Gene_expression of TRPV4 1 0.14 0 0.06
159 INT309752 CALM3 Positive_regulation of Gene_expression of CA2 1 0.04 0 0.06
160 INT258290 Hmgb1 Regulation of Positive_regulation of Tlr2 1 0.46 1.04 0.05
161 INT220537 HSPG2 Positive_regulation of NOSTRIN 1 0.04 0 0.05
162 INT183853 Gene_expression of CAV1 Negative_regulation of Positive_regulation of MAPK1 1 0.28 0.25 0.05
163 INT324861 Positive_regulation of Binding of Tlr1 and Tlr6 1 0.05 0.79 0.05
164 INT324867 Positive_regulation of Binding of Tlr6 and Tlr2 1 0.10 0.79 0.05
165 INT249193 Negative_regulation of CA2 Negative_regulation of Binding of AKT1 1 0.03 0.08 0.05
166 INT193966 AKT1 Negative_regulation of Gsk3b 1 0.05 0.75 0.05
167 INT193969 AKT1 Negative_regulation of Phosphorylation of Gsk3b 1 0.05 0.75 0.05
168 INT328429 PRB4 Negative_regulation of Gene_expression of AKT1 1 0.03 0.52 0.05
169 INT324872 Binding of Tlr1 and Tlr6 1 0.04 0.79 0.05
170 INT299302 Negative_regulation of RPTOR Regulation of AKT1 1 0.30 0.1 0.05
171 INT324864 Positive_regulation of Binding of Tlr1 and Tlr2 1 0.10 0.79 0.05
172 INT309730 Binding of CALM3 and TYRP1 1 0.01 0 0.05
173 INT299304 RPTOR Regulation of AKT1 1 0.19 0.1 0.05
174 INT328434 PRB4 Negative_regulation of AKT1 1 0.02 0.29 0.05
175 INT89384 Negative_regulation of INS Positive_regulation of AKT1 2 0.36 1.37 0.04
176 INT276969 Tlr2 Positive_regulation of Il10 1 0.20 0.75 0.04
177 INT249170 Binding of AKT1 and ARHGDIA 1 0.00 0.15 0.04
178 INT276955 Tlr2 Positive_regulation of Negative_regulation of Il13 1 0.14 0.76 0.04
179 INT276978 Tlr2 Positive_regulation of Hspd1 1 0.27 0.68 0.04
180 INT276973 Tlr2 Positive_regulation of Il13 1 0.14 0.76 0.04
181 INT261057 Binding of CALM3 and CHGA 1 0.04 0.14 0.04
182 INT276981 Tlr2 Positive_regulation of Gene_expression of Il13 1 0.13 0.76 0.04
183 INT276990 Tlr2 Positive_regulation of Negative_regulation of Il10 1 0.20 0.75 0.04
184 INT200645 Binding of AKT1 and TBK1 1 0.02 0.43 0.04
185 INT350434 Negative_regulation of HSP90AA1 Positive_regulation of Gene_expression of ATF3 1 0.32 2.44 0.04
186 INT347291 Binding of AKT1 and CCL16 1 0.06 0.99 0.04
187 INT347299 Binding of AKT1 and ITK 1 0.04 0.99 0.04
188 INT261042 Binding of CALM3 and VIP 1 0.00 0.14 0.04
189 INT266661 AKT1 Regulation of BAD 2 0.10 1.86 0.03
190 INT315066 AKT1 Negative_regulation of PAR4 1 0.39 1.8 0.03
191 INT234196 ERBB2 Positive_regulation of Negative_regulation of HSP90AA1 1 0.19 0.79 0.03
192 INT265891 IGF1 Regulation of AKT1 1 0.05 1.24 0.03
193 INT231438 LEP Positive_regulation of Negative_regulation of NOS3 1 0.09 0.32 0.03
194 INT324805 Tlr2 Positive_regulation of Cd14 1 0.14 0.09 0.03
195 INT276989 Stat3 Regulation of Positive_regulation of Tlr2 1 0.22 0.13 0.03
196 INT328362 LYPLA1 Regulation of Ghrl 1 0.04 0.07 0.03
197 INT269838 Binding of Hsp90b1 and Tlr2 1 0.26 1.75 0.03
198 INT291356 CXCL12 Positive_regulation of AKT1 1 0.04 1.28 0.03
199 INT231439 LEP Positive_regulation of Negative_regulation of AKT1 1 0.06 0.32 0.03
200 INT347295 CCL16 Positive_regulation of Gene_expression of AKT1 1 0.12 0.29 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported for nitric oxide metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in nitric oxide metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142594 Gene_expression of Tlr2 165 0.78 139.73 22.26
2 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
3 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
4 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
5 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
6 INT142593 Positive_regulation of Tlr2 85 0.70 75.9 13.62
7 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
8 INT83201 Gene_expression of NOS3 93 0.78 47.16 12.48
9 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05
10 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27
11 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68
12 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14
13 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92
14 INT152347 Binding of GCH1 8 0.37 6.13 7.36
15 INT142596 Positive_regulation of Gene_expression of Tlr2 42 0.69 38.41 6.67
16 INT163776 Regulation of GCH1 7 0.27 4.58 6.16
17 INT97018 Binding of CALM3 7 0.43 0.13 5.82
18 INT142595 Negative_regulation of Tlr2 24 0.52 19.17 5.43
19 INT174688 Binding of Tlr2 45 0.42 36.65 5.25
20 INT145756 Gene_expression of Tlr2 23 0.74 20.77 5.18
21 INT111594 Positive_regulation of Gene_expression of NOSTRIN 20 0.32 8.69 5
22 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
23 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
24 INT153666 Gene_expression of CAV1 156 0.77 120.99 3.9
25 INT70958 Binding of NOS3 19 0.37 11.84 3.29
26 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
27 INT92814 Negative_regulation of NOS3 25 0.51 20.67 3.07
28 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
29 INT91869 Transcription of NOS3 13 0.67 6.81 2.86
30 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
31 INT150933 Negative_regulation of Positive_regulation of GCH1 3 0.58 1.8 2.77
32 INT150932 Positive_regulation of Gene_expression of GCH1 3 0.70 2.07 2.57
33 INT165434 Regulation of SPR 4 0.24 2.14 2.33
34 INT283973 Transcription of GCH1 1 0.61 1.99 2.33
35 INT110304 Negative_regulation of Gene_expression of NOSTRIN 6 0.55 2.22 2.27
36 INT283975 Negative_regulation of Localization of GCH1 1 0.38 1.99 2.27
37 INT54540 Negative_regulation of Cps1 7 0.58 2.64 2.26
38 INT118791 Binding of AKT1 32 0.48 15.51 2.25
39 INT96856 Localization of NOSTRIN 8 0.49 6.39 2.19
40 INT204775 Regulation of Tlr2 21 0.41 13.6 2.18
41 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
42 INT82166 Regulation of NOS3 14 0.54 7.57 2.08
43 INT91594 Localization of NOS3 12 0.78 5.39 2.02
44 INT258637 Regulation of Gene_expression of GCH1 1 0.62 1.77 2.02
45 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
46 INT228195 Negative_regulation of Gene_expression of Tlr2 14 0.40 12.17 1.74
47 INT107923 Regulation of Gene_expression of NOS3 11 0.61 2.73 1.73
48 INT94892 Regulation of NOSTRIN 7 0.31 2.99 1.72
49 INT7333 Localization of CALM3 4 0.72 0.4 1.55
50 INT167894 Negative_regulation of PTS 3 0.14 3.96 1.54
51 INT38043 Gene_expression of Cps1 6 0.56 0.82 1.46
52 INT125320 Negative_regulation of HSP90AA1 20 0.45 23.93 1.42
53 INT181639 Positive_regulation of Positive_regulation of NOS3 8 0.41 3.72 1.41
54 INT174683 Transcription of Tlr2 12 0.58 5.95 1.4
55 INT91863 Negative_regulation of Gene_expression of NOS3 13 0.51 9.43 1.34
56 INT62896 Binding of NOSTRIN 4 0.30 2.86 1.3
57 INT221131 Localization of Tlr2 17 0.80 13.82 1.28
58 INT45175 Gene_expression of PTS 5 0.56 1.46 1.24
59 INT167409 Regulation of Gene_expression of AKT1 8 0.56 4.86 1.23
60 INT135556 Localization of AKT1 38 0.69 12.78 1.17
61 INT190804 Positive_regulation of Tlr2 6 0.66 3.7 1.16
62 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15
63 INT139764 Negative_regulation of CAV1 10 0.58 6.57 1.14
64 INT22353 Positive_regulation of Cps1 6 0.17 0.98 1.14
65 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13
66 INT283974 Negative_regulation of Transcription of GCH1 1 0.38 0.99 1.13
67 INT283972 Localization of GCH1 1 0.67 0.99 1.13
68 INT283976 Positive_regulation of Binding of GCH1 1 0.45 1.27 1.13
69 INT133898 Binding of HSP90AA1 17 0.30 8.83 1.12
70 INT159477 Phosphorylation of NOS3 14 0.72 1.54 1.08
71 INT97017 Regulation of Binding of CALM3 2 0.40 0 1.06
72 INT150931 Negative_regulation of GCH1 6 0.59 1.23 1.05
73 INT97383 Positive_regulation of Positive_regulation of NOSTRIN 2 0.08 1.53 1.05
74 INT107922 Positive_regulation of Gene_expression of NOS3 17 0.60 9.32 1.04
75 INT7338 Negative_regulation of CALM3 5 0.34 0.19 1
76 INT73960 Regulation of Gene_expression of NOSTRIN 3 0.54 1.41 0.97
77 INT97014 Regulation of CALM3 1 0.55 0 0.97
78 INT97020 Negative_regulation of Regulation of CALM3 1 0.52 0 0.97
79 INT77856 Binding of Cps1 6 0.30 2.32 0.95
80 INT288493 Positive_regulation of Gene_expression of Tlr2 4 0.66 4.38 0.94
81 INT80450 Positive_regulation of SPR 3 0.41 0.9 0.93
82 INT153670 Positive_regulation of Gene_expression of CAV1 26 0.69 44.27 0.92
83 INT145760 Binding of Tlr2 5 0.46 3.59 0.89
84 INT7335 Positive_regulation of CALM3 6 0.36 0.28 0.79
85 INT83375 Gene_expression of CALM3 3 0.58 1.57 0.78
86 INT152474 Phosphorylation of Cps1 1 0.06 0 0.78
87 INT130057 Positive_regulation of CAV1 12 0.65 8.96 0.77
88 INT165430 Gene_expression of SPR 2 0.59 1.27 0.75
89 INT224630 Positive_regulation of Positive_regulation of Tlr2 6 0.46 4.14 0.73
90 INT228188 Regulation of Gene_expression of Tlr2 5 0.45 6.96 0.71
91 INT152562 Regulation of Transcription of NOS3 1 0.23 0.34 0.71
92 INT153667 Localization of CAV1 15 0.76 11.92 0.68
93 INT299338 Negative_regulation of Regulation of AKT1 2 0.31 2.32 0.68
94 INT157186 Regulation of Cps1 4 0.22 0.54 0.67
95 INT69349 Transcription of NOSTRIN 2 0.50 0.49 0.66
96 INT166024 Protein_catabolism of AKT1 5 0.46 2.6 0.64
97 INT199029 Binding of SPR 2 0.06 0.85 0.6
98 INT131001 Regulation of CAV1 6 0.44 3.77 0.59
99 INT123131 Negative_regulation of Negative_regulation of AKT1 6 0.42 3.23 0.58
100 INT159476 Positive_regulation of Phosphorylation of NOS3 6 0.44 1.43 0.58
101 INT165846 Regulation of HSP90AA1 4 0.27 2.19 0.58
102 INT174274 Positive_regulation of Localization of NOSTRIN 2 0.09 2.35 0.58
103 INT94564 Positive_regulation of Negative_regulation of NOSTRIN 1 0.38 0.35 0.57
104 INT234597 Negative_regulation of Positive_regulation of Tlr2 2 0.30 2.25 0.52
105 INT234587 Positive_regulation of Transcription of Tlr2 3 0.36 1.84 0.51
106 INT91864 Negative_regulation of Transcription of NOS3 4 0.54 1.41 0.48
107 INT153672 Negative_regulation of Negative_regulation of CAV1 1 0.25 0.2 0.46
108 INT159479 Positive_regulation of Binding of NOS3 2 0.50 0.63 0.41
109 INT97384 Negative_regulation of Positive_regulation of NOSTRIN 3 0.12 0.93 0.4
110 INT307593 Localization of PTS 1 0.67 0.4 0.4
111 INT80449 Negative_regulation of SPR 1 0.24 0.08 0.38
112 INT174684 Gene_expression of Tlr6 2 0.44 2.62 0.36
113 INT163277 Negative_regulation of Gene_expression of CAV1 17 0.56 10.77 0.35
114 INT173213 Regulation of PTS 2 0.38 2.18 0.31
115 INT288189 Negative_regulation of Negative_regulation of Tlr2 1 0.26 0.43 0.28
116 INT288186 Regulation of Binding of Tlr2 2 0.32 1.72 0.26
117 INT224614 Regulation of Positive_regulation of Tlr2 1 0.13 0.56 0.26
118 INT261086 Positive_regulation of Negative_regulation of CALM3 1 0.16 0 0.26
119 INT233915 Protein_catabolism of NOSTRIN 1 0.02 1.6 0.24
120 INT323315 Gene_expression of LYPLA1 1 0.50 1.23 0.24
121 INT246583 Negative_regulation of Negative_regulation of NOSTRIN 1 0.04 0.63 0.24
122 INT304603 Positive_regulation of HSP90AA1 1 0.26 7.01 0.24
123 INT145758 Regulation of Tlr2 3 0.43 0.94 0.23
124 INT145761 Negative_regulation of Tlr2 2 0.41 1.97 0.23
125 INT100914 Binding of PTS 5 0.36 3.81 0.21
126 INT200666 Transcription of AKT1 8 0.66 4.23 0.2
127 INT269409 Regulation of Phosphorylation of NOS3 1 0.18 0 0.2
128 INT92815 Positive_regulation of Negative_regulation of NOS3 1 0.12 1.03 0.2
129 INT38044 Regulation of Gene_expression of Cps1 1 0.38 0 0.19
130 INT269403 Regulation of Positive_regulation of NOS3 1 0.18 0 0.17
131 INT131000 Positive_regulation of Positive_regulation of CAV1 1 0.49 0 0.17
132 INT324855 Binding of Tlr6 1 0.14 2.39 0.17
133 INT176153 Regulation of Negative_regulation of AKT1 3 0.39 2.13 0.16
134 INT294633 Positive_regulation of Binding of Tlr2 1 0.44 0.42 0.16
135 INT135557 Positive_regulation of Localization of AKT1 3 0.46 0.49 0.15
136 INT163278 Regulation of Gene_expression of CAV1 5 0.45 4.36 0.14
137 INT145759 Regulation of Gene_expression of Tlr2 3 0.43 0.98 0.14
138 INT302248 Negative_regulation of Binding of AKT1 2 0.25 1 0.14
139 INT83316 Positive_regulation of LYPLA1 3 0.50 0.56 0.13
140 INT94893 Regulation of Positive_regulation of NOSTRIN 1 0.01 0.51 0.13
141 INT301958 Positive_regulation of Regulation of Tlr2 1 0.21 0.32 0.13
142 INT285902 Positive_regulation of Transcription of AKT1 1 0.06 0.6 0.13
143 INT102355 Gene_expression of HSP90AA1 8 0.51 5.2 0.12
144 INT269395 Regulation of Binding of NOS3 2 0.39 1.84 0.12
145 INT7334 Positive_regulation of Localization of CALM3 1 0.42 0.17 0.12
146 INT329058 Positive_regulation of Transcription of Tlr2 1 0.48 0.62 0.11
147 INT329049 Transcription of Tlr2 1 0.68 0.62 0.11
148 INT186558 Negative_regulation of Positive_regulation of NOS3 2 0.37 0.26 0.1
149 INT309767 Negative_regulation of Gene_expression of CALM3 1 0.13 0 0.1
150 INT324777 Positive_regulation of Tlr6 2 0.22 0.88 0.09
151 INT192238 Positive_regulation of Localization of NOS3 2 0.21 0.76 0.09
152 INT309756 Positive_regulation of Gene_expression of CALM3 1 0.14 0 0.09
153 INT255976 Regulation of Transcription of Tlr2 1 0.22 0.89 0.09
154 INT192239 Positive_regulation of Binding of AKT1 2 0.26 0.91 0.08
155 INT276932 Localization of Tlr6 1 0.40 0.23 0.07
156 INT269821 Regulation of Localization of Tlr2 1 0.27 1.04 0.07
157 INT182302 Negative_regulation of Localization of AKT1 5 0.39 3.52 0.06
158 INT234206 Localization of HSP90AA1 4 0.68 2.89 0.06
159 INT234211 Regulation of Negative_regulation of HSP90AA1 2 0.27 1.13 0.06
160 INT189245 Binding of LYPLA1 1 0.02 0.56 0.06
161 INT234207 Negative_regulation of Binding of HSP90AA1 2 0.26 0.84 0.05
162 INT314252 Transcription of CAV1 1 0.50 0.07 0.04
163 INT246930 Negative_regulation of Transcription of Tlr2 1 0.36 0.92 0.04
164 INT276929 Regulation of Tlr6 1 0.24 0.74 0.04
165 INT145757 Negative_regulation of Gene_expression of Tlr2 2 0.41 0.68 0.03
166 INT300989 Positive_regulation of Negative_regulation of AKT1 2 0.41 1.27 0.03
167 INT183878 Negative_regulation of Positive_regulation of CAV1 1 0.41 0.16 0.03
168 INT234208 Negative_regulation of Localization of HSP90AA1 1 0.26 0.59 0.03
169 INT276939 Positive_regulation of Phosphorylation of Tlr2 1 0.46 0.6 0.03
170 INT323317 Regulation of LYPLA1 1 0.34 0.09 0.03
171 INT276931 Phosphorylation of Tlr2 1 0.75 0.6 0.03
172 INT183883 Binding of CAV1 8 0.46 3.89 0
173 INT234209 Protein_catabolism of HSP90AA1 5 0.54 2.67 0
174 INT45174 Positive_regulation of PTS 3 0.45 0 0
175 INT234212 Positive_regulation of Gene_expression of HSP90AA1 3 0.41 1.36 0
176 INT246929 Positive_regulation of Localization of Tlr2 2 0.42 0.26 0
177 INT156919 Phosphorylation of NOSTRIN 2 0.30 0.18 0
178 INT156921 Positive_regulation of Phosphorylation of NOSTRIN 2 0.26 0.18 0
179 INT234213 Regulation of Binding of HSP90AA1 1 0.27 0.21 0
180 INT350514 Positive_regulation of Phosphorylation of HSP90AA1 1 0.10 0.74 0
181 INT246927 Negative_regulation of Binding of Tlr2 1 0.31 0 0
182 INT311072 Positive_regulation of Localization of HSP90AA1 1 0.22 0.53 0
183 INT336827 Regulation of Regulation of NOS3 1 0.23 0.51 0
184 INT200400 Negative_regulation of Binding of PTS 1 0.27 0.82 0
185 INT183890 Regulation of Negative_regulation of CAV1 1 0.43 0.38 0
186 INT350518 Phosphorylation of HSP90AA1 1 0.16 0.72 0
187 INT288581 Negative_regulation of Binding of CAV1 1 0.03 0 0
188 INT323312 Protein_catabolism of LYPLA1 1 0.49 0.08 0
189 INT48334 Regulation of Negative_regulation of NOSTRIN 1 0.43 0.08 0
190 INT261087 Negative_regulation of Positive_regulation of CALM3 1 0.12 0 0
191 INT269015 Positive_regulation of Gene_expression of SPR 1 0.08 0.12 0
192 INT174535 Negative_regulation of Negative_regulation of NOS3 1 0.11 0.32 0
193 INT309760 Negative_regulation of Binding of CALM3 1 0.13 0 0
194 INT288580 Regulation of Binding of CAV1 1 0.03 0 0
195 INT163775 Negative_regulation of Regulation of GCH1 1 0.43 0 0
196 INT198028 Regulation of Regulation of AKT1 1 0.22 1.08 0
197 INT223603 Regulation of Localization of AKT1 1 0.23 0.65 0
198 INT169661 Localization of Cps1 1 0.62 0.09 0
199 INT234205 Negative_regulation of Negative_regulation of HSP90AA1 1 0.26 0.28 0
200 INT350445 Positive_regulation of Negative_regulation of HSP90AA1 1 0.30 3.25 0
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