GO:0046328

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Name regulation of JNK cascade
Categary Process
Go Slim No
Go Link GO:0046328
Unique Molecular Interactions 387
Total Molecular Interactions 493
Total Single Events 5196
Pain Genes Associated 25

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of JNK cascade. They are ordered first by their pain relevance and then by number of times they were reported for regulation of JNK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67
2 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
3 INT128044 Bdnf Positive_regulation of Ephb1 2 0.31 1.89 2.57
4 INT327940 Crh Positive_regulation of Gene_expression of F2rl1 1 0.44 5.57 2.5
5 INT121746 Prkaca Positive_regulation of Ephb1 2 0.23 0.92 2.35
6 INT156623 Umod Regulation of Phosphorylation of Ephb1 1 0.05 0.33 2.27
7 INT96652 F2rl1 Positive_regulation of Tac1 1 0.47 2.62 2.25
8 INT229394 TPSD1 Positive_regulation of F2RL1 2 0.00 3.11 2.14
9 INT153533 NMS Regulation of Gene_expression of Ephb1 1 0.48 3.96 1.93
10 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89
11 INT112517 Binding of Ephb1 and Prkaca 3 0.18 0.58 1.85
12 INT162992 Binding of Ephb1 and Ppm1e 1 0.03 0.25 1.77
13 INT249483 Binding of Ephb1 and Efnb2 1 0.02 2.35 1.66
14 INT131575 Grin1 Negative_regulation of Positive_regulation of Ephb1 1 0.28 0.31 1.58
15 INT131574 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Creb1 1 0.41 0.33 1.58
16 INT158778 Ptges3l1 Regulation of Ephb1 1 0.06 0.09 1.53
17 INT158775 Regulation of Tnf Regulation of Ephb1 1 0.18 0.09 1.52
18 INT158777 Tnf Regulation of Ephb1 1 0.18 0.09 1.51
19 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
20 INT256299 Binding of Efnb1 and Ephb1 1 0.02 1.22 1.42
21 INT249494 Binding of Ephb1 and Efnb1 1 0.01 1.34 1.4
22 INT261483 Binding of Ephb1 and Trpv1 1 0.39 1.37 1.37
23 INT107858 PRSS1 Positive_regulation of F2RL1 6 0.12 4.23 1.29
24 INT95406 Trib3 Positive_regulation of Ephb1 2 0.08 0.96 1.29
25 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
26 INT121729 Negative_regulation of Ngf Positive_regulation of Ephb1 1 0.24 0.69 1.22
27 INT256298 Binding of Creb1 and Ephb1 1 0.16 1.27 1.22
28 INT121724 Ngf Positive_regulation of Ephb1 1 0.40 0.68 1.21
29 INT181490 Tryptase Positive_regulation of F2rl1 1 0.13 1.83 1.21
30 INT334351 Bdnf Regulation of Positive_regulation of Ephb1 1 0.18 1.27 1.2
31 INT249481 Positive_regulation of Binding of Ephb1 and Efnb2 1 0.03 1.36 1.12
32 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
33 INT269190 Positive_regulation of Ephb1 Positive_regulation of Ceacam3 1 0.03 0.66 1.12
34 INT156238 Binding of F2rl1 and Tnfsf14 1 0.08 2.85 1.08
35 INT256294 Binding of Grin2b and Ephb1 1 0.28 1.11 1.08
36 INT156462 Creb1 Regulation of Ephb1 1 0.29 0 1.07
37 INT269192 Ephb1 Regulation of Phosphorylation of Grin2a 1 0.02 0.63 1.06
38 INT121727 Pik3cb Positive_regulation of Ephb1 1 0.49 0.6 1.06
39 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
40 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
41 INT240455 Ephb1 Positive_regulation of Positive_regulation of Prkaca 1 0.22 0.63 1.01
42 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
43 INT341371 CRX Positive_regulation of Gene_expression of Ephb1 1 0.02 0.99 0.9
44 INT119100 Positive_regulation of F2rl1 Positive_regulation of Positive_regulation of Ptgs1 1 0.03 0.56 0.9
45 INT126268 Tpsab1 Positive_regulation of F2rl1 2 0.35 1.65 0.88
46 INT121745 Tacr1 Negative_regulation of Positive_regulation of Ephb1 1 0.04 0 0.87
47 INT134993 P2rx6 Regulation of Ephb1 1 0.20 1.27 0.87
48 INT196578 Ephb1 Positive_regulation of Phosphorylation of Mapk9 1 0.13 0.5 0.85
49 INT196576 Trib3 Positive_regulation of Phosphorylation of Mapk9 1 0.02 0.5 0.85
50 INT196638 TNF Positive_regulation of F2RL1 2 0.09 1.52 0.84
51 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
52 INT261480 Negative_regulation of Trib3 Positive_regulation of Ephb1 1 0.04 0.8 0.84
53 INT261479 Fig4 Positive_regulation of Ephb1 1 0.07 0.79 0.83
54 INT335644 CTSB Positive_regulation of F2RL1 1 0.02 2.58 0.82
55 INT334358 Rvm Positive_regulation of Ephb1 1 0.17 0.98 0.82
56 INT334359 Negative_regulation of Rvm Positive_regulation of Ephb1 1 0.16 0.99 0.82
57 INT156239 Tnfsf14 Positive_regulation of F2rl1 1 0.09 2.4 0.81
58 INT124292 Binding of Trpv1 and F2rl1 1 0.46 1.1 0.81
59 INT128042 Bdnf Positive_regulation of Phosphorylation of Ephb1 1 0.22 0.2 0.8
60 INT240456 Ephb1 Regulation of Prkcg 1 0.19 0.51 0.79
61 INT117971 Cd8a Negative_regulation of Positive_regulation of Ephb1 1 0.02 0.98 0.79
62 INT240454 Ephb1 Regulation of Prkaca 1 0.14 0.51 0.79
63 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
64 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77
65 INT224463 TPSAB1 Positive_regulation of F2RL1 2 0.03 1.49 0.76
66 INT162995 Positive_regulation of Binding of Ephb1 and Ppm1e 1 0.04 0.06 0.74
67 INT341534 INSRR Positive_regulation of F2RL1 1 0.00 1.4 0.7
68 INT328625 NPL Regulation of Phosphorylation of Ephb1 1 0.04 0.42 0.7
69 INT154989 Phax Positive_regulation of Positive_regulation of Ephb1 1 0.22 0.92 0.69
70 INT112515 Binding of Ephb1 and Trib3 1 0.06 0.41 0.65
71 INT197240 Grik2 Regulation of Gene_expression of Gabrg1 1 0.08 0.13 0.64
72 INT197236 Grik2 Regulation of Gabrg1 1 0.08 0.13 0.64
73 INT252857 Binding of F2rl1 and Trpa1 1 0.22 0.84 0.63
74 INT330104 Binding of Sh3rf1 and Rac1 1 0.13 2.41 0.62
75 INT330101 Binding of Map3k11 and Rac1 1 0.16 2.43 0.62
76 INT128817 Ephb1 Negative_regulation of Gene_expression of Nos2 1 0.16 0.37 0.61
77 INT128814 Ephb1 Negative_regulation of Gene_expression of Il1b 1 0.02 0.37 0.61
78 INT138332 Binding of P2rx3 and F2rl1 1 0.35 0.25 0.59
79 INT261482 Pik3cb Positive_regulation of Phosphorylation of Ephb1 1 0.23 0.67 0.58
80 INT112312 tryptase Positive_regulation of F2rl1 2 0.08 0.23 0.57
81 INT261485 Positive_regulation of Prkaca Positive_regulation of Phosphorylation of Ephb1 1 0.05 0.12 0.56
82 INT261478 Positive_regulation of Ephb1 Regulation of Gene_expression of Egr1 1 0.10 0.23 0.55
83 INT312746 Ephb1 Positive_regulation of Localization of Ltp 1 0.05 0.07 0.55
84 INT256296 Efnb1 Positive_regulation of Ephb1 1 0.03 0.66 0.54
85 INT132372 Lgals1 Positive_regulation of Ephb1 1 0.37 0.25 0.54
86 INT249499 Ephb1 Positive_regulation of Efnb2 1 0.04 0.95 0.54
87 INT249479 Binding of Ephb1 and Grin2b 1 0.29 0.37 0.54
88 INT193554 Ntrk2 Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.73 0.52
89 INT171914 MAPK8IP3 Positive_regulation of Gene_expression of MAPK1 1 0.06 1.55 0.52
90 INT104960 Ephb1 Regulation of Positive_regulation of Mapk14 1 0.15 0.42 0.5
91 INT104961 Mapk14 Regulation of Positive_regulation of Ephb1 1 0.15 0.42 0.5
92 INT153534 Binding of Ephb1 and NMS 1 0.29 1.13 0.5
93 INT100726 TNF Positive_regulation of Gene_expression of F2RL1 2 0.27 1.9 0.46
94 INT249486 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Grin2b 1 0.33 0.4 0.46
95 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
96 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
97 INT312813 Binding of F2rl1 and Tpsab1 1 0.01 0.26 0.46
98 INT149006 RPL7AP5 Negative_regulation of Phosphorylation of Ephb1 1 0.00 0.22 0.45
99 INT127392 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin1 1 0.08 0.71 0.45
100 INT127393 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Nfkb1 1 0.10 0.7 0.45
101 INT127394 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Grin2a 1 0.01 0.71 0.45
102 INT127391 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Elk1 1 0.08 0.71 0.45
103 INT127395 Negative_regulation of Ephb1 Negative_regulation of Gene_expression of Tacr1 1 0.07 0.71 0.45
104 INT127390 Negative_regulation of Ephb1 Negative_regulation of Phosphorylation of Elk1 1 0.08 0.7 0.44
105 INT149005 RPL7AP5 Negative_regulation of Ephb1 1 0.00 0.21 0.44
106 INT265647 Binding of Ephb1 and Mapk1 1 0.00 1.48 0.43
107 INT156234 Tnfsf14 Positive_regulation of Transcription of F2rl1 1 0.09 1.26 0.42
108 INT95403 Ephb1 Regulation of Positive_regulation of Trib3 1 0.07 0.19 0.41
109 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
110 INT156233 Positive_regulation of Tnfsf14 Positive_regulation of F2rl1 1 0.09 1.15 0.4
111 INT150333 4930519F16Rik Positive_regulation of F2rl1 1 0.00 0.67 0.38
112 INT304501 Binding of Ephb1 and Mapk1 1 0.18 0.69 0.36
113 INT112619 Mapk9 Regulation of Il1b 1 0.16 1.11 0.36
114 INT224284 BDNF Positive_regulation of Ephb1 1 0.36 0.22 0.36
115 INT112620 Mapk9 Regulation of Tnf 1 0.16 1.11 0.36
116 INT270220 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Pla2g4a 1 0.13 1 0.36
117 INT309151 Dlat Positive_regulation of Positive_regulation of Ephb1 1 0.02 0.57 0.33
118 INT342882 Positive_regulation of Ephb1 Regulation of Gene_expression of Pdyn 1 0.01 0.36 0.33
119 INT309128 Edc4 Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.58 0.33
120 INT337412 AKT3 Negative_regulation of Localization of AKT2 1 0.09 0.5 0.32
121 INT337418 AKT2 Negative_regulation of Localization of AKT3 1 0.09 0.5 0.32
122 INT348016 Binding of Mapk8 and Mapk8ip3 1 0.04 2.09 0.32
123 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
124 INT224461 F2RL1 Positive_regulation of CALCRL 1 0.00 0.37 0.31
125 INT249480 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Src 1 0.22 0.23 0.31
126 INT330100 Binding of Sh3rf1 and Map3k11 1 0.08 1.21 0.31
127 INT341777 SLC6A4 Regulation of EPHB1 1 0.02 0.96 0.3
128 INT135014 Binding of Ephb1 and Cabin1 1 0.09 0.32 0.3
129 INT218936 Dusp1 Negative_regulation of Ephb1 2 0.03 0.89 0.28
130 INT218934 Cyp3a23/3a1 Negative_regulation of Ephb1 1 0.01 0.95 0.28
131 INT224462 Positive_regulation of F2RL1 Positive_regulation of MMP1 1 0.10 0.47 0.28
132 INT309121 Positive_regulation of Gsdmc Positive_regulation of Positive_regulation of Ephb1 1 0.01 0.76 0.28
133 INT292570 Binding of F2RL1 and HTR1A 1 0.07 0.8 0.28
134 INT292568 Binding of F2RL1 and MRGPRX1 1 0.07 0.81 0.28
135 INT132373 Ephb1 Positive_regulation of Positive_regulation of Nfkb1 1 0.18 0.12 0.28
136 INT132364 Ephb1 Positive_regulation of Nfkb1 1 0.07 0.11 0.27
137 INT309134 Edc4 Positive_regulation of Ephb1 1 0.01 0.54 0.27
138 INT316929 Pde5a Regulation of Ephb1 1 0.03 0.17 0.27
139 INT132370 Mapk8 Positive_regulation of Ephb1 1 0.15 0.12 0.27
140 INT292571 Positive_regulation of F2RL1 Positive_regulation of Localization of IL6 1 0.07 0.8 0.27
141 INT309133 Dlat Positive_regulation of Ephb1 1 0.02 0.54 0.27
142 INT171912 MAPK8IP3 Positive_regulation of MAPK9 1 0.06 0.78 0.26
143 INT179928 Binding of Ephb1 and Mapk8 1 0.11 0.91 0.26
144 INT149947 Ephb1 Positive_regulation of Prkcg 1 0.27 0.07 0.26
145 INT171911 MAPK8IP3 Positive_regulation of Gene_expression of MAPK14 1 0.05 0.77 0.26
146 INT149948 Ephb1 Negative_regulation of Phosphorylation of Map2 1 0.37 0.07 0.25
147 INT292563 F2RL1 Negative_regulation of TNF 1 0.15 0.73 0.25
148 INT92581 IGF1R Positive_regulation of Gene_expression of PTGER2 1 0.09 0.79 0.24
149 INT341538 F2 Positive_regulation of F2RL1 1 0.02 0.68 0.24
150 INT292556 Binding of F2RL1 and TLR4 1 0.05 0.52 0.22
151 INT292557 Binding of F2RL1 and MYD88 1 0.08 0.52 0.22
152 INT157692 Cck Positive_regulation of Ephb1 1 0.26 0 0.21
153 INT159794 Tnf Positive_regulation of Mapk9 1 0.01 0.42 0.19
154 INT159793 Tnf Positive_regulation of Gene_expression of Mapk9 1 0.01 0.42 0.19
155 INT334631 Igf1r Positive_regulation of Phosphorylation of Akt1 1 0.19 0.5 0.18
156 INT207151 PLA2G6 Positive_regulation of Localization of F2rl1 1 0.16 0.73 0.18
157 INT341531 F2RL1 Regulation of CD55 1 0.33 0.41 0.18
158 INT207147 Pla2g1b Positive_regulation of Localization of F2rl1 1 0.03 0.73 0.18
159 INT306261 AKT2 Negative_regulation of Phosphorylation of FOXO1 1 0.25 0.41 0.17
160 INT333299 Zic2 Regulation of Transcription of Ephb1 1 0.50 0.09 0.17
161 INT108663 Lrpap1 Negative_regulation of Positive_regulation of Ephb1 1 0.11 0.28 0.17
162 INT108667 ras Negative_regulation of Positive_regulation of Ephb1 1 0.02 0.28 0.17
163 INT261477 Egf Positive_regulation of Positive_regulation of Ephb1 1 0.37 0.21 0.17
164 INT348034 Mapk8ip3 Negative_regulation of Mapk8 1 0.05 0.98 0.16
165 INT193546 Il1b Positive_regulation of Ephb1 1 0.12 0.35 0.16
166 INT348019 Negative_regulation of Binding of Mapk8 and Mapk8ip3 1 0.05 1.04 0.16
167 INT168941 Irs2 Regulation of Gene_expression of Igf1r 1 0.39 0.91 0.16
168 INT334634 Binding of Igf1 and Igf1r 1 0.14 0.45 0.15
169 INT92582 IGF1R Positive_regulation of Transcription of PTGER2 1 0.09 0.43 0.15
170 INT179931 Ephb1 Regulation of Gene_expression of Mmp9 1 0.04 0.48 0.15
171 INT105253 Positive_regulation of Binding of Rnpep and F2rl1 1 0.02 0 0.15
172 INT105252 Binding of Rnpep and F2rl1 1 0.01 0 0.15
173 INT193550 Ephb1 Positive_regulation of Gene_expression of Bdnf 1 0.29 0.3 0.14
174 INT193553 Mtpn Positive_regulation of Ephb1 1 0.04 0.34 0.13
175 INT193548 Gdnf Positive_regulation of Ephb1 1 0.40 0.34 0.13
176 INT147357 Mapk9 Positive_regulation of Htr5a 1 0.06 0.76 0.12
177 INT207109 F2 Positive_regulation of Phosphorylation of Akt2 1 0.08 0.25 0.12
178 INT254643 Binding of Mapk8ip1 and Slc9a3r2 1 0.00 0.27 0.12
179 INT147362 Mapk9 Positive_regulation of Ddit3 1 0.57 0.76 0.12
180 INT147361 Mapk9 Positive_regulation of Tnfrsf10b 1 0.40 0.76 0.12
181 INT207112 Sh2b2 Positive_regulation of Phosphorylation of Akt2 1 0.68 0.24 0.12
182 INT207115 Sh2b2 Positive_regulation of Akt2 1 0.49 0.24 0.12
183 INT341529 PRSS1 Positive_regulation of Gene_expression of F2RL1 1 0.06 0 0.11
184 INT341543 PRSS1 Positive_regulation of Transcription of F2RL1 1 0.06 0 0.11
185 INT181076 Map4k4 Positive_regulation of Mapk8 1 0.11 0.47 0.11
186 INT128696 Il1a Positive_regulation of Phosphorylation of Ephb1 1 0.26 0.82 0.1
187 INT251569 Binding of Ripk1 and Traf2 1 0.12 0.67 0.08
188 INT292569 F2RL1 Positive_regulation of Negative_regulation of MAPK8 1 0.22 0 0.08
189 INT249126 Binding of Ephb1 and Mtor 1 0.02 0 0.08
190 INT337087 Negative_regulation of Binding of Mif and Cops5 1 0.13 1.64 0.08
191 INT310564 Positive_regulation of Ephb1 Regulation of Stat3 1 0.03 0.17 0.08
192 INT109864 Negative_regulation of ras Positive_regulation of Ephb1 1 0.01 0.37 0.08
193 INT337088 Binding of Mif and Cops5 1 0.12 1.63 0.08
194 INT109865 ras Positive_regulation of Ephb1 1 0.01 0.37 0.08
195 INT309112 Edc4 Regulation of Positive_regulation of Ephb1 1 0.01 0.15 0.07
196 INT184924 Ephb1 Positive_regulation of Agtrap 1 0.01 0.08 0.06
197 INT234619 IGF1 Regulation of IGF1R 1 0.11 0.39 0.05
198 INT143647 Negative_regulation of Mapk8ip1 Negative_regulation of Gene_expression of Fas 1 0.02 0.15 0.05
199 INT234624 Binding of IGF1 and IGF1R 1 0.09 0.39 0.05
200 INT282140 Ephb1 Regulation of Grip2 1 0.00 0 0.05

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of JNK cascade. They are ordered first by their pain relevance and then by number of times they were reported in regulation of JNK cascade. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14
2 INT63934 Phosphorylation of Ephb1 377 0.82 150.52 188.66
3 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9
4 INT63936 Positive_regulation of Phosphorylation of Ephb1 131 0.70 49.38 73.16
5 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11
6 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02
7 INT48929 Regulation of Ephb1 71 0.62 24.42 42.11
8 INT100733 Positive_regulation of F2RL1 62 0.70 59.14 35.22
9 INT63933 Negative_regulation of Positive_regulation of Ephb1 53 0.58 22.83 33.43
10 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05
11 INT84494 Negative_regulation of Phosphorylation of Ephb1 44 0.59 22.34 28.68
12 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46
13 INT123035 Gene_expression of Ephb1 38 0.78 28.84 27.32
14 INT90849 Gene_expression of F2rl1 55 0.78 31.31 20.65
15 INT100732 Gene_expression of F2RL1 55 0.78 38.89 19.45
16 INT109379 Regulation of Phosphorylation of Ephb1 22 0.59 12.58 18.84
17 INT92733 Negative_regulation of Ephb1 19 0.51 8.56 17.72
18 INT128921 Negative_regulation of Gene_expression of Ephb1 18 0.49 9.54 14.93
19 INT104674 Positive_regulation of F2rl1 35 0.65 27.76 14.16
20 INT84496 Regulation of Positive_regulation of Ephb1 18 0.61 10.16 13.92
21 INT135909 Positive_regulation of Ephb1 11 0.70 8.94 11.78
22 INT127853 Localization of Ephb1 20 0.74 5.47 7.96
23 INT147715 Regulation of Gene_expression of Ephb1 6 0.62 5.26 7.49
24 INT103791 Positive_regulation of Positive_regulation of F2rl1 10 0.50 11.24 7.41
25 INT92734 Binding of Ephb1 5 0.37 3.86 7.02
26 INT48922 Regulation of Gene_expression of Ephb1 14 0.50 5.73 6.47
27 INT118516 Positive_regulation of Positive_regulation of F2RL1 7 0.49 4.63 6.33
28 INT181053 Regulation of Ephb1 6 0.45 6.17 5.77
29 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
30 INT90848 Localization of F2rl1 23 0.80 3.15 5.2
31 INT126847 Binding of Ephb1 15 0.46 6.47 5.17
32 INT105256 Positive_regulation of Gene_expression of F2rl1 6 0.68 10.09 4.83
33 INT108919 Positive_regulation of Mapk9 9 0.34 3.55 4.74
34 INT107860 Positive_regulation of Gene_expression of F2RL1 10 0.68 6.36 3.88
35 INT104480 Phosphorylation of Mapk9 8 0.80 6.59 3.62
36 INT100729 Localization of F2RL1 7 0.75 5.29 3.37
37 INT200670 Gene_expression of AKT2 25 0.75 16.25 3
38 INT133085 Gene_expression of Mapk8ip1 7 0.66 6.13 2.98
39 INT256286 Negative_regulation of Gene_expression of Ephb1 1 0.43 3.36 2.78
40 INT224481 Regulation of F2RL1 4 0.37 5.07 2.74
41 INT95737 Positive_regulation of Phosphorylation of Mapk8ip1 2 0.06 3.27 2.74
42 INT161942 Regulation of Gene_expression of F2RL1 12 0.62 4.84 2.73
43 INT111017 Regulation of F2rl1 3 0.22 0 2.61
44 INT133083 Positive_regulation of Gene_expression of Mapk8ip1 1 0.07 3.27 2.47
45 INT111016 Gene_expression of F2rl1 11 0.73 3.58 2.37
46 INT138331 Binding of F2rl1 4 0.36 1.92 2.32
47 INT95736 Phosphorylation of Mapk8ip1 2 0.10 2.84 2.32
48 INT114433 Positive_regulation of Positive_regulation of F2rl1 4 0.49 3.5 2.29
49 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
50 INT224480 Binding of F2RL1 5 0.36 5.2 2.19
51 INT111018 Binding of F2rl1 5 0.30 3.11 2.02
52 INT108921 Negative_regulation of Positive_regulation of Mapk9 3 0.25 1.8 1.99
53 INT224496 Negative_regulation of F2RL1 3 0.48 1.85 1.97
54 INT9336 Negative_regulation of Gene_expression of Igf1r 4 0.42 3.53 1.92
55 INT104478 Positive_regulation of Mapk9 5 0.67 5.56 1.81
56 INT124667 Negative_regulation of Grik2 4 0.41 2.06 1.7
57 INT104479 Negative_regulation of Mapk9 3 0.37 2.83 1.69
58 INT98788 Negative_regulation of EPHB1 11 0.37 3.65 1.64
59 INT158773 Positive_regulation of Localization of Ephb1 1 0.34 0.08 1.64
60 INT117717 Negative_regulation of Regulation of Ephb1 3 0.41 0.61 1.61
61 INT142678 Positive_regulation of Phosphorylation of Mapk9 4 0.51 2.1 1.6
62 INT147713 Localization of Ephb1 1 0.70 0 1.54
63 INT135907 Negative_regulation of Positive_regulation of Ephb1 1 0.38 0.42 1.51
64 INT135908 Regulation of Negative_regulation of Ephb1 1 0.24 0.4 1.49
65 INT142676 Phosphorylation of Mapk9 5 0.61 1.48 1.48
66 INT124669 Gene_expression of Grik2 6 0.75 1.66 1.47
67 INT135906 Positive_regulation of Positive_regulation of Ephb1 1 0.44 0.38 1.45
68 INT212466 Regulation of EPHB1 7 0.37 5.72 1.42
69 INT96651 Negative_regulation of F2rl1 4 0.37 2.26 1.4
70 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39
71 INT159784 Gene_expression of Mapk9 8 0.61 6.28 1.37
72 INT142679 Negative_regulation of Phosphorylation of Mapk9 1 0.17 0.51 1.37
73 INT90226 Gene_expression of Mapk9 3 0.65 1.94 1.34
74 INT119743 Negative_regulation of Positive_regulation of F2rl1 3 0.43 1.97 1.3
75 INT143646 Negative_regulation of Mapk8ip1 5 0.03 5.46 1.28
76 INT190067 Binding of Traf2 5 0.20 3.28 1.27
77 INT327936 Regulation of Gene_expression of F2rl1 1 0.61 2.62 1.26
78 INT117719 Transcription of Ephb1 2 0.44 0.06 1.25
79 INT9323 Transcription of Igf1r 2 0.63 1.08 1.23
80 INT166274 Gene_expression of EPHB1 14 0.55 8.2 1.19
81 INT160054 Localization of AKT2 4 0.73 1.93 1.18
82 INT131970 Regulation of Grik2 3 0.26 0.65 1.15
83 INT224494 Regulation of Positive_regulation of F2RL1 4 0.37 1.67 1.11
84 INT147416 Positive_regulation of Transcription of Igf1r 1 0.46 0.72 1.1
85 INT147415 Positive_regulation of Igf1r 2 0.43 0.97 1.09
86 INT140054 Negative_regulation of Mapk9 3 0.25 1.9 1.05
87 INT159330 Positive_regulation of Localization of F2rl1 1 0.49 0.34 1.02
88 INT112311 Regulation of F2rl1 2 0.27 0.73 0.97
89 INT240461 Regulation of Negative_regulation of Ephb1 4 0.37 1.66 0.96
90 INT224489 Negative_regulation of Gene_expression of F2RL1 3 0.57 1.51 0.96
91 INT101495 Regulation of Positive_regulation of F2rl1 1 0.26 0.88 0.91
92 INT160056 Positive_regulation of AKT2 3 0.48 1.43 0.88
93 INT271605 Regulation of Gene_expression of AKT2 1 0.44 0.81 0.87
94 INT196583 Regulation of Phosphorylation of Mapk9 1 0.37 0.5 0.85
95 INT104482 Positive_regulation of Phosphorylation of Mapk9 2 0.49 1.55 0.84
96 INT147716 Negative_regulation of Localization of Ephb1 1 0.51 0 0.84
97 INT131967 Transcription of Grik2 2 0.67 0.73 0.82
98 INT114714 Binding of IGF1R 8 0.36 5.26 0.78
99 INT97782 Protein_catabolism of Ephb1 5 0.86 1.27 0.76
100 INT131966 Regulation of Regulation of Grik2 1 0.26 0.45 0.75
101 INT200669 Negative_regulation of AKT2 2 0.42 0.94 0.72
102 INT104488 Negative_regulation of Phosphorylation of Mapk9 1 0.41 1.03 0.72
103 INT292595 Negative_regulation of Positive_regulation of F2RL1 3 0.40 1.29 0.63
104 INT100730 Positive_regulation of Localization of F2RL1 2 0.49 0.99 0.62
105 INT127854 Regulation of Localization of Ephb1 1 0.25 0.69 0.62
106 INT297831 Protein_catabolism of F2rl1 2 0.10 0.5 0.6
107 INT154745 Protein_catabolism of Traf2 1 0.86 1.04 0.59
108 INT154750 Positive_regulation of Protein_catabolism of Traf2 1 0.60 1.05 0.59
109 INT294555 Negative_regulation of Traf2 1 0.06 1.24 0.58
110 INT104483 Positive_regulation of Positive_regulation of Mapk9 1 0.49 0.75 0.56
111 INT104484 Regulation of Mapk9 1 0.12 0.73 0.55
112 INT145859 Regulation of Gene_expression of Igf1r 1 0.59 1.58 0.55
113 INT249507 Regulation of Binding of Ephb1 1 0.38 0.58 0.55
114 INT124290 Negative_regulation of Gene_expression of F2rl1 3 0.42 1.48 0.52
115 INT190074 Positive_regulation of Traf2 1 0.19 0.37 0.52
116 INT126849 Positive_regulation of Binding of Ephb1 3 0.49 0.24 0.5
117 INT92328 Gene_expression of Map3k11 1 0.06 0.46 0.49
118 INT111019 Negative_regulation of Binding of F2rl1 1 0.35 0 0.48
119 INT333283 Positive_regulation of Gene_expression of Ephb1 3 0.32 1.17 0.47
120 INT167975 Negative_regulation of Gene_expression of Mapk9 2 0.02 1.18 0.47
121 INT271604 Positive_regulation of Gene_expression of AKT2 2 0.49 0.22 0.47
122 INT167981 Negative_regulation of Negative_regulation of Mapk8ip1 1 0.01 0.91 0.45
123 INT274928 Negative_regulation of Binding of Ephb1 1 0.40 0 0.44
124 INT156226 Transcription of F2rl1 1 0.23 1.25 0.41
125 INT166066 Negative_regulation of Localization of F2rl1 1 0.43 0.47 0.4
126 INT156230 Positive_regulation of Binding of F2rl1 1 0.21 1.11 0.4
127 INT179413 Positive_regulation of Mapk8ip1 1 0.01 0.97 0.4
128 INT112310 Negative_regulation of Regulation of F2rl1 1 0.03 0 0.39
129 INT193542 Regulation of Regulation of Ephb1 2 0.25 0.79 0.38
130 INT168940 Phosphorylation of Igf1r 1 0.77 2.18 0.38
131 INT292591 Negative_regulation of Negative_regulation of F2RL1 1 0.35 0 0.36
132 INT342161 Positive_regulation of Gene_expression of Mapk9 1 0.09 0.63 0.35
133 INT210766 Gene_expression of Igf1r 6 0.65 2.15 0.31
134 INT323118 Positive_regulation of Localization of AKT2 2 0.49 0.48 0.31
135 INT330091 Binding of Sh3rf1 1 0.15 1.2 0.31
136 INT330099 Binding of Map3k11 1 0.24 1.21 0.31
137 INT179917 Negative_regulation of Negative_regulation of Ephb1 2 0.25 1.17 0.28
138 INT163893 Positive_regulation of Phosphorylation of EPHB1 1 0.49 0.43 0.27
139 INT95740 Negative_regulation of Phosphorylation of Mapk8ip1 1 0.01 0 0.27
140 INT207096 Phosphorylation of Akt2 1 0.72 0.51 0.27
141 INT163892 Phosphorylation of EPHB1 1 0.80 0.42 0.27
142 INT224491 Transcription of F2RL1 1 0.68 0.31 0.26
143 INT94657 Transcription of F2rl1 1 0.69 0.5 0.26
144 INT105257 Regulation of Localization of F2rl1 1 0.23 0 0.26
145 INT154934 Negative_regulation of Positive_regulation of Mapk9 1 0.35 0.41 0.23
146 INT140059 Localization of Mapk9 1 0.28 0.61 0.23
147 INT192958 Negative_regulation of IGF1R 8 0.30 6.35 0.21
148 INT250517 Phosphorylation of Igf1r 5 0.79 1.21 0.21
149 INT213792 Positive_regulation of Igf1r 3 0.45 1 0.2
150 INT274731 Binding of EPHB1 3 0.22 0.76 0.2
151 INT168938 Negative_regulation of Phosphorylation of Igf1r 1 0.40 1.1 0.19
152 INT200676 Phosphorylation of AKT2 1 0.53 1.01 0.19
153 INT207129 Localization of F2rl1 1 0.22 0.72 0.18
154 INT181029 Transcription of Ephb1 2 0.51 0.51 0.17
155 INT154744 Regulation of Protein_catabolism of Traf2 1 0.39 0.18 0.16
156 INT179260 Binding of AKT2 2 0.27 1.8 0.15
157 INT168939 Negative_regulation of Igf1r 1 0.40 1.01 0.15
158 INT181056 Gene_expression of Map4k4 1 0.69 1.54 0.15
159 INT292590 Positive_regulation of Negative_regulation of F2RL1 1 0.38 0 0.15
160 INT286401 Gene_expression of Akt2 8 0.72 1.36 0.13
161 INT9320 Regulation of Transcription of Igf1r 1 0.04 0.36 0.13
162 INT9333 Regulation of Igf1r 1 0.07 0.36 0.13
163 INT251559 Binding of Traf2 1 0.23 1.68 0.13
164 INT92590 Positive_regulation of Gene_expression of IGF1R 3 0.57 2.31 0.12
165 INT140057 Negative_regulation of Negative_regulation of Mapk9 1 0.15 0.31 0.12
166 INT92589 Positive_regulation of IGF1R 4 0.38 0.98 0.11
167 INT140051 Negative_regulation of Localization of Mapk9 1 0.20 0.31 0.11
168 INT341581 Positive_regulation of Transcription of F2RL1 1 0.44 0 0.11
169 INT312954 Regulation of Binding of IGF1R 1 0.13 0 0.1
170 INT250519 Negative_regulation of Igf1r 5 0.42 2.7 0.09
171 INT251560 Positive_regulation of Traf2 1 0.13 0.47 0.09
172 INT173212 Positive_regulation of Gene_expression of EPHB1 1 0.04 1.22 0.08
173 INT92587 Positive_regulation of Positive_regulation of IGF1R 1 0.38 0.38 0.08
174 INT349623 Negative_regulation of Binding of Igf1r 1 0.39 0.51 0.08
175 INT250508 Negative_regulation of Gene_expression of Igf1r 1 0.42 2.01 0.08
176 INT349620 Binding of Igf1r 1 0.34 0.51 0.08
177 INT178419 Regulation of Mapk9 1 0.09 0.76 0.08
178 INT280787 Gene_expression of Mapk8ip3 1 0.01 0.24 0.07
179 INT292586 Phosphorylation of F2RL1 1 0.51 0 0.07
180 INT254642 Binding of Mapk8ip1 1 0.32 0.22 0.07
181 INT292582 Negative_regulation of Phosphorylation of F2RL1 1 0.35 0 0.07
182 INT234462 Phosphorylation of IGF1R 2 0.42 0.99 0.06
183 INT207067 Localization of Akt2 2 0.69 0.59 0.04
184 INT315099 Localization of IGF1R 2 0.55 0.36 0.04
185 INT285978 Negative_regulation of Gene_expression of Mapk8ip1 1 0.01 0.66 0.04
186 INT286411 Binding of Akt2 1 0.34 0.23 0.04
187 INT200687 Positive_regulation of Phosphorylation of AKT2 1 0.33 0.43 0.04
188 INT217725 Localization of EPHB1 4 0.45 0.21 0.03
189 INT234471 Negative_regulation of Phosphorylation of IGF1R 1 0.04 0.76 0.03
190 INT334692 Localization of Igf1r 1 0.09 0.89 0.03
191 INT222308 Regulation of IGF1R 3 0.12 2.18 0
192 INT339214 Negative_regulation of Gene_expression of IGF1R 2 0.22 0.4 0
193 INT282728 Regulation of Igf1r 2 0.18 0.92 0
194 INT286386 Positive_regulation of Akt2 2 0.61 0.45 0
195 INT212465 Positive_regulation of EPHB1 2 0.08 1.93 0
196 INT246763 Gene_expression of Akt2 2 0.53 1.22 0
197 INT134692 Positive_regulation of Negative_regulation of Ephb1 1 0.23 0.07 0
198 INT321694 Positive_regulation of Phosphorylation of Igf1r 1 0.27 0.2 0
199 INT338259 Positive_regulation of Binding of IGF1R 1 0.27 1.38 0
200 INT200678 Transcription of AKT2 1 0.47 0.57 0
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