GO:0046332

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Name SMAD binding
Categary Function
Go Slim No
Go Link GO:0046332
Unique Molecular Interactions 343
Total Molecular Interactions 455
Total Single Events 2849
Pain Genes Associated 52

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for SMAD binding. They are ordered first by their pain relevance and then by number of times they were reported for SMAD binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT114929 Positive_regulation of Binding of Oprm1 and Crebbp 1 0.06 0.14 1.28
2 INT114925 Binding of Oprm1 and Crebbp 1 0.06 0.14 1.27
3 INT228680 Fkbp1a Negative_regulation of Trib3 1 0.01 0.56 1.18
4 INT107938 POMC Positive_regulation of Gene_expression of TGFBR2 1 0.42 1.09 1.07
5 INT75486 Binding of Tgfbr1 and Tgfbr2 1 0.10 1.94 1.02
6 INT210783 Bmp2 Positive_regulation of Tnip1 1 0.40 0.53 0.94
7 INT210791 Bmp2 Positive_regulation of Net1 1 0.38 0.52 0.93
8 INT210799 Bmp2 Positive_regulation of B2m 1 0.35 0.52 0.92
9 INT107937 POMC Regulation of Gene_expression of TGFBR2 1 0.28 0.82 0.81
10 INT161951 Positive_regulation of TGFBR1 Positive_regulation of Gene_expression of Ngf 1 0.27 0.99 0.76
11 INT161945 TGFB2 Positive_regulation of TGFBR1 1 0.08 0.99 0.76
12 INT161950 TGFBR1 Negative_regulation of Localization of Ngf 1 0.23 1.01 0.72
13 INT148452 Inhbe Regulation of Acvrl1 1 0.01 0.69 0.69
14 INT232622 Magi2 Regulation of Cysltr1 1 0.01 0.58 0.67
15 INT167651 Binding of Oprd1 and Ep300 1 0.02 0.09 0.55
16 INT343913 Binding of FOS and Smad3 1 0.19 0.92 0.54
17 INT302644 ARSA Positive_regulation of Gene_expression of TGFBR1 1 0.04 0.29 0.51
18 INT167652 Binding of Ep300 and Ngf 1 0.09 0.06 0.51
19 INT167655 Binding of Polr2f and Ep300 1 0.01 0.06 0.51
20 INT302647 ARSA Positive_regulation of TGFBR1 1 0.03 0.29 0.51
21 INT319718 Binding of Crebbp and Creb1 1 0.10 1.68 0.48
22 INT210793 Bmp2 Positive_regulation of Tsc22d3 1 0.32 0.26 0.46
23 INT195552 Binding of Rela and Ep300 1 0.03 0.2 0.45
24 INT195554 Binding of Nfkb1 and Ep300 1 0.08 0.2 0.45
25 INT75488 Binding of TGFB1 and Tgfbr1 1 0.23 0.78 0.41
26 INT75489 Binding of SGCG and Tgfbr2 1 0.23 0.83 0.41
27 INT75487 Binding of TGFB1 and Tgfbr2 1 0.31 0.83 0.41
28 INT320810 Protein_catabolism of COL1A2 Positive_regulation of Localization of CYP27A1 1 0.04 1.05 0.4
29 INT342783 Prdm16 Positive_regulation of Gene_expression of Gal 1 0.02 0.72 0.37
30 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37
31 INT319729 Binding of Rela and Crebbp 1 0.02 0.88 0.37
32 INT124378 Prodh2 Positive_regulation of Ctnnb1 1 0.00 0.59 0.35
33 INT182837 Binding of Creb1 and Crebbp 1 0.12 0.57 0.32
34 INT198566 Ddit4l Regulation of Axin1 1 0.03 1 0.31
35 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31
36 INT102849 Tgfb1 Positive_regulation of Gene_expression of Col3a1 1 0.04 0.85 0.3
37 INT166165 Binding of TGFB3 and Bmp2 1 0.00 0 0.3
38 INT137023 Gene_expression of SMAD2 Negative_regulation of Gene_expression of Acta2 1 0.00 0.43 0.29
39 INT179838 Col3a1 Regulation of Negative_regulation of Il11 1 0.21 0 0.29
40 INT302467 TIMP1 Positive_regulation of Negative_regulation of COL5A2 1 0.00 1.1 0.29
41 INT182817 EEF1A2 Positive_regulation of BMP2 1 0.26 1.62 0.28
42 INT311918 Insrr Negative_regulation of Tgfbr1 1 0.00 0.87 0.26
43 INT311902 Acvrl1 Negative_regulation of Tgfbr1 1 0.13 0.87 0.26
44 INT311900 Acvrl1 Negative_regulation of Insrr 1 0.00 0.86 0.25
45 INT243640 Binding of Twist1 and Stub1 1 0.08 0.34 0.24
46 INT266006 Binding of COL5A2 and SGCG 1 0.00 0.89 0.23
47 INT311911 Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
48 INT311908 Acvrl1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.55 0.23
49 INT285639 Col3a1 Regulation of Tnfrsf12a 1 0.19 0.16 0.22
50 INT173558 CTSK Positive_regulation of Protein_catabolism of COL5A2 1 0.00 0.53 0.22
51 INT353285 Prdx2 Regulation of Gene_expression of Col1a2 1 0.02 0.73 0.21
52 INT115142 TGM7 Positive_regulation of Gene_expression of CITED2 1 0.02 0.45 0.2
53 INT255516 Binding of COL5A2 and GP6 1 0.01 1.17 0.2
54 INT325529 Binding of Stat3 and Ep300 1 0.01 0.22 0.19
55 INT92694 Tgfb1 Positive_regulation of Positive_regulation of Col3a1 1 0.31 0.89 0.19
56 INT325531 Positive_regulation of Binding of Stat3 and Ep300 1 0.02 0.22 0.19
57 INT333449 Binding of SMAD2 and SMAD4 1 0.23 0 0.17
58 INT217074 Binding of Acsm3 and Axin1 1 0.00 5.37 0.17
59 INT119265 Binding of CREBBP and PPM1E 1 0.01 0.46 0.17
60 INT333447 Binding of SMAD2 and RXRA 1 0.04 0 0.16
61 INT323803 NFAT5 Positive_regulation of Regulation of COL5A2 1 0.07 0.46 0.16
62 INT194811 Binding of Crebbp and Nfatc1 1 0.00 0.07 0.16
63 INT185793 SPP1 Positive_regulation of COL1A2 1 0.16 0.33 0.16
64 INT323805 NFAT5 Regulation of COL5A2 1 0.07 0.46 0.16
65 INT194826 Binding of CREB1 and Crebbp 1 0.02 0.07 0.16
66 INT264868 Binding of COL1A2 and GOPC 1 0.02 0.3 0.15
67 INT95103 TGFBR2 Positive_regulation of CD34 1 0.11 0.61 0.14
68 INT95104 TGFBR2 Positive_regulation of BCL2 1 0.08 0.61 0.14
69 INT309779 PTH Negative_regulation of Gene_expression of COL5A2 1 0.00 0.52 0.14
70 INT180960 Protein_catabolism of COL5A2 Positive_regulation of Positive_regulation of NPEPPS 1 0.00 0.59 0.14
71 INT180963 COL5A2 Positive_regulation of Positive_regulation of NPEPPS 1 0.00 0.59 0.14
72 INT314852 Binding of Cdkn2a and Tgfbr3 1 0.28 1.15 0.14
73 INT314859 Binding of Cdkn2b and Tgfbr3 1 0.33 1.16 0.14
74 INT209645 AR Regulation of STUB1 1 0.04 0.93 0.13
75 INT251115 Positive_regulation of Binding of AR and Ctnnb1 1 0.01 1.02 0.13
76 INT244847 Lbx1 Positive_regulation of Skor1 1 0.47 0.08 0.13
77 INT157602 Binding of COL1A1 and COL3A1 1 0.04 0 0.13
78 INT287878 Binding of CREB1 and CREBBP 2 0.01 0.16 0.12
79 INT207776 Binding of FKBP1A and RYR1 1 0.05 0.59 0.12
80 INT319726 Crebbp Positive_regulation of Binding of Rela 1 0.02 0.37 0.12
81 INT319731 Ep300 Positive_regulation of Binding of Rela 1 0.01 0.37 0.12
82 INT172976 Mras Regulation of Gene_expression of Smad4 1 0.00 0.83 0.12
83 INT251114 Binding of AR and Ctnnb1 1 0.01 1 0.12
84 INT326974 BMP2 Positive_regulation of Gene_expression of COL2A1 1 0.07 0.27 0.11
85 INT319727 Binding of Crebbp and Ep300 1 0.02 0.36 0.11
86 INT266003 Binding of COL5A2 and DIO3 1 0.01 0.43 0.11
87 INT319728 Positive_regulation of Binding of Crebbp and Ep300 1 0.03 0.36 0.11
88 INT323869 Binding of BMI1 and COL1A2 1 0.00 1.21 0.11
89 INT262207 Binding of Nr1i2 and Ep300 1 0.14 1.08 0.11
90 INT69909 Binding of MYC and PURA 1 0.24 0 0.1
91 INT205055 MMP3 Negative_regulation of COL1A2 1 0.32 1.52 0.1
92 INT316823 Sparc Positive_regulation of Phosphorylation of Smad2 1 0.44 0.49 0.1
93 INT207459 LGALS3 Regulation of Gene_expression of COL1A2 1 0.06 0.21 0.1
94 INT238038 Binding of BMP2 and OPLL 1 0.20 2.45 0.09
95 INT323868 LEP Regulation of Transcription of COL1A2 1 0.10 0.98 0.09
96 INT336425 MGAT1 Positive_regulation of Gene_expression of COL5A2 1 0.00 0.4 0.08
97 INT311917 Gene_expression of Tgfbr1 Positive_regulation of Gene_expression of Mmp13 1 0.10 0.31 0.08
98 INT297968 Positive_regulation of Binding of BMP2 and IL17C 1 0.21 0.26 0.08
99 INT323876 LEP Regulation of COL1A2 1 0.10 0.86 0.08
100 INT297970 Binding of BMP2 and IL17C 1 0.15 0.26 0.08
101 INT277053 Protein_catabolism of TIMP1 Positive_regulation of COL5A2 1 0.01 0.14 0.07
102 INT119268 CDKN1A Regulation of CREBBP 1 0.21 0.44 0.07
103 INT311915 Tgfbr1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
104 INT295122 Bmp2 Regulation of Grxcr1 1 0.02 0.66 0.06
105 INT317426 Binding of CSF2 and PML 1 0.08 1.25 0.06
106 INT311903 Acvrl1 Negative_regulation of Gene_expression of Mmp13 1 0.09 0.27 0.06
107 INT304331 Binding of COL5A2 and TGFBI 1 0.01 0.38 0.06
108 INT311916 Smad3 Negative_regulation of Gene_expression of Mmp13 1 0.12 0.27 0.06
109 INT311910 Acvrl1 Positive_regulation of Phosphorylation of Smad1 1 0.12 0.24 0.06
110 INT311906 Binding of Smad4 and Insrr 1 0.00 0.18 0.06
111 INT295120 Bmp2 Regulation of Transcription of Pou1f1 1 0.24 0.66 0.06
112 INT255512 Binding of COL5A2 and CRP 1 0.01 0 0.06
113 INT298258 Binding of Runx3 and Stub1 1 0.11 0.18 0.06
114 INT262173 Binding of Msx2 and Ep300 1 0.07 0.55 0.06
115 INT353284 Prdx2 Negative_regulation of Gene_expression of Smad2 1 0.16 0.07 0.05
116 INT346280 Binding of COL5A2 and PTK2 1 0.01 0.1 0.05
117 INT293360 Binding of CSH1 and FKBP1A 1 0.00 0.14 0.05
118 INT207760 Fkbp1a Regulation of MSMB 1 0.12 0.69 0.04
119 INT353290 Binding of Smad2 and Smad4 1 0.20 0.08 0.04
120 INT170328 Gene_expression of Ido1 Positive_regulation of Hmga2 1 0.01 0.13 0.04
121 INT353294 Binding of Smad2 and Smad3 1 0.15 0.08 0.04
122 INT353295 Binding of Smad3 and Smad4 1 0.17 0.08 0.04
123 INT213815 Binding of Tfeb and Stub1 1 0.13 0.09 0.04
124 INT179840 Binding of Col3a1 and Sparc 1 0.25 0 0.04
125 INT353289 Prdx2 Negative_regulation of Positive_regulation of Smad2 1 0.18 0.17 0.04
126 INT353293 Prdx2 Negative_regulation of Localization of Smad2 1 0.16 0 0.04
127 INT225569 Binding of Ncoa6 and Ep300 1 0.18 0.63 0.04
128 INT311904 Smad2 Positive_regulation of Gene_expression of Smad1 1 0.13 0.44 0.03
129 INT261727 TNF Regulation of COL5A2 1 0.05 0.21 0.03
130 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03
131 INT265347 Binding of Ocln and Tgfbr1 1 0.18 0.06 0.03
132 INT265345 Binding of Tgfbr1 and Tjp1 1 0.09 0.06 0.03
133 INT353286 Prdx2 Positive_regulation of Phosphorylation of Smad2 1 0.24 0.06 0.03
134 INT173613 BMP2 Positive_regulation of INCENP 1 0.00 0.28 0.03
135 INT261731 PSMB6 Regulation of COL5A2 1 0.00 0.21 0.03
136 INT293358 Binding of FKBP1A and CABIN1 1 0.00 0.07 0.03
137 INT280263 Binding of Smad4 and Proc 1 0.00 1.26 0.03
138 INT180954 PASK Regulation of COL5A2 1 0.00 0.7 0.03
139 INT254852 Binding of Col7a1 and Smad3 1 0.01 0.57 0.03
140 INT287674 Skor2 Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.03
141 INT287233 PDLIM7 Positive_regulation of Gene_expression of BMP2 1 0.07 0.12 0.03
142 INT261733 F2 Regulation of COL5A2 1 0.03 0.21 0.03
143 INT287675 Skor2 Positive_regulation of Phosphorylation of Gopc 1 0.02 0 0.03
144 INT265343 Positive_regulation of Binding of Tgfbr1 and Tjp1 1 0.12 0.06 0.03
145 INT265348 Positive_regulation of Binding of Ocln and Tgfbr1 1 0.25 0.06 0.03
146 INT277927 WIF1 Negative_regulation of SMAD4 1 0.23 0.37 0
147 INT314869 Binding of Gdf11 and Tgfbr3 1 0.29 0.14 0
148 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
149 INT261729 COL5A2 Regulation of Gene_expression of F2R 1 0.18 0 0
150 INT269943 Sox17 Regulation of Binding of Smad3 1 0.37 0.12 0
151 INT254849 Negative_regulation of Rhoa Positive_regulation of Phosphorylation of Smad3 1 0.11 0.45 0
152 INT262169 Binding of Foxa2 and Nr1i2 1 0.17 0.33 0
153 INT275231 Binding of ACVRL1 and AK3 1 0.01 0.72 0
154 INT225562 Binding of Srcs4 and Ep300 1 0.02 0 0
155 INT269915 Binding of Smad2 and Sox17 1 0.21 0.07 0
156 INT262183 Foxa2 Positive_regulation of Gene_expression of Hmgcs2 1 0.10 0.22 0
157 INT343999 INCENP Positive_regulation of BMP2 1 0.01 0 0
158 INT265231 Binding of FKBP1A and TGFBR1 1 0.11 0.35 0
159 INT355603 Binding of CTNNA1 and Ctnnb1 1 0.00 1.07 0
160 INT313117 Binding of Stub1 and Carf 1 0.10 0 0
161 INT293355 Binding of Fkbp1a and CABIN1 1 0.00 0.12 0
162 INT220818 Binding of Ctnnb1 and Myc 1 0.06 0.13 0
163 INT278021 BMP2 Positive_regulation of Gene_expression of RUNX1T1 1 0.02 0.5 0
164 INT269937 Binding of Smad3 and Mgst1 1 0.09 0 0
165 INT273116 Binding of Fkbp1a and Mtor 1 0.37 0 0
166 INT218669 Olr811 Negative_regulation of Phosphorylation of Smad2 1 0.01 0.18 0
167 INT243106 Binding of Crebbp and Src 1 0.05 0.52 0
168 INT254745 Binding of Anxa3 and Skil 1 0.00 0 0
169 INT314871 Binding of Tgfbr3 and Atoh7 1 0.33 0.09 0
170 INT269919 Sox17 Negative_regulation of Binding of Smad3 1 0.36 0 0
171 INT286566 Binding of Ctnnb1 and Cdh6 1 0.00 1 0
172 INT337915 Tgfbr1 Positive_regulation of Negative_regulation of Smad2 1 0.05 0.15 0
173 INT265344 sb Negative_regulation of Tgfbr1 1 0.00 0.06 0
174 INT286562 Gene_expression of Pkd1 Positive_regulation of Ctnnb1 1 0.02 0.52 0
175 INT205451 Binding of BMP2 and Acvr2a 1 0.02 0.05 0
176 INT136693 Gtf3a Positive_regulation of Ctnnb1 1 0.05 0 0
177 INT245731 Binding of COL5A2 and DISC1 1 0.01 0.42 0
178 INT272513 Binding of Mef2a and Eif2s2 1 0.03 0 0
179 INT268345 Binding of TGFB1 and TGFBR2 1 0.27 0.62 0
180 INT287882 Binding of CREBBP and HNF4A 1 0.01 0.85 0
181 INT297209 Myoz1 Regulation of Mef2a 1 0.04 0.09 0
182 INT269924 Smad3 Regulation of Gene_expression of Cdkn2b 1 0.23 0.26 0
183 INT196959 Hmga2 Positive_regulation of Localization of E2f1 1 0.54 0.24 0
184 INT184210 IL1B Negative_regulation of Gene_expression of COL1A2 1 0.04 0 0
185 INT287885 Binding of DVL1 and AXIN1 1 0.02 0 0
186 INT269955 Positive_regulation of Binding of Smad3 and Sox17 1 0.39 0.05 0
187 INT189556 Binding of COL5A2 and SPARCL1 1 0.00 1.22 0
188 INT189551 Binding of COL5A2 and DCN 1 0.00 0.72 0
189 INT254863 Tgfb1 Positive_regulation of Transcription of Smad3 1 0.03 0.23 0
190 INT243107 Binding of Src and Ep300 1 0.06 0.17 0
191 INT254747 Positive_regulation of Binding of Skil and Fig4 1 0.03 0.14 0
192 INT196023 Bmp2 Negative_regulation of Gene_expression of Bmp4 1 0.09 0.07 0
193 INT316811 Negative_regulation of Col1a2 Negative_regulation of Col3a1 1 0.33 0.07 0
194 INT269936 Smad2 Positive_regulation of Cdkn2b 1 0.15 0.07 0
195 INT261734 COL5A2 Regulation of Gene_expression of ACTB 1 0.17 0 0
196 INT205410 Binding of BMP2 and BMPR2 1 0.07 0.05 0
197 INT269954 Sox17 Regulation of Gene_expression of Foxa2 1 0.43 0 0
198 INT172606 EP300 Positive_regulation of CREBBP 1 0.00 0.07 0
199 INT196940 Positive_regulation of Hmga2 Positive_regulation of E2f1 1 0.50 0.47 0
200 INT293354 Binding of CSH1 and Fkbp1a 1 0.00 0.12 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for SMAD binding. They are ordered first by their pain relevance and then by number of times they were reported in SMAD binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44
2 INT173587 Protein_catabolism of COL5A2 59 0.32 32.73 8.96
3 INT17024 Gene_expression of COL1A2 69 0.77 36.38 8.29
4 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48
5 INT127112 Phosphorylation of Smad2 19 0.80 11.01 5.36
6 INT84561 Binding of COL1A2 18 0.47 11.76 5.09
7 INT60575 Binding of Fkbp1a 9 0.26 2.09 4.46
8 INT22973 Gene_expression of Col3a1 22 0.42 15.85 4.32
9 INT156137 Gene_expression of Col1a2 28 0.73 13.3 3.99
10 INT75485 Gene_expression of Tgfbr2 10 0.57 10.98 3.76
11 INT64919 Gene_expression of Prdm16 6 0.75 11.63 3.5
12 INT49238 Protein_catabolism of COL1A2 30 0.97 15.64 3.45
13 INT36032 Gene_expression of Col3a1 23 0.72 10.55 3.18
14 INT75484 Gene_expression of Tgfbr1 21 0.64 13.36 3.15
15 INT34977 Gene_expression of Hmga2 11 0.76 12.39 3.07
16 INT85809 Gene_expression of BMP2 46 0.78 9.91 3.05
17 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01
18 INT101567 Gene_expression of Ctnnb1 7 0.64 10.11 2.89
19 INT14448 Localization of COL5A2 34 0.67 17.35 2.85
20 INT95105 Gene_expression of TGFBR2 15 0.64 16.36 2.74
21 INT127113 Positive_regulation of Phosphorylation of Smad2 1 0.68 2.38 2.51
22 INT173592 Binding of COL5A2 32 0.33 9.14 2.48
23 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28
24 INT61684 Localization of COL1A2 20 0.73 9.31 2.26
25 INT194504 Gene_expression of Smad2 27 0.65 7.45 2.25
26 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23
27 INT89519 Negative_regulation of COL1A2 10 0.36 6.26 2.17
28 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12
29 INT26123 Regulation of Ep300 6 0.23 1.22 2.03
30 INT81641 Gene_expression of Ctnnb1 23 0.72 14.93 1.97
31 INT26124 Negative_regulation of Ep300 5 0.37 1.25 1.94
32 INT107178 Gene_expression of Smad4 12 0.65 9.85 1.92
33 INT69181 Positive_regulation of Col3a1 10 0.33 5.54 1.91
34 INT152155 Positive_regulation of Col1a2 7 0.56 10.18 1.89
35 INT84375 Regulation of COL1A2 6 0.44 8.75 1.72
36 INT97062 Binding of PML 10 0.41 11.63 1.65
37 INT123990 Positive_regulation of Ctnnb1 8 0.43 2.85 1.63
38 INT99391 Localization of Ctnnb1 7 0.80 5.84 1.61
39 INT139317 Negative_regulation of Col1a2 8 0.41 7.17 1.54
40 INT127115 Regulation of Phosphorylation of Smad2 1 0.60 1.74 1.53
41 INT255251 Negative_regulation of Smad2 12 0.32 5.69 1.44
42 INT130014 Positive_regulation of BMP2 11 0.66 5.34 1.42
43 INT62669 Positive_regulation of COL1A2 13 0.49 6.89 1.4
44 INT310167 Gene_expression of Acvrl1 2 0.40 5.47 1.4
45 INT71847 Positive_regulation of Positive_regulation of Col3a1 2 0.33 0.61 1.39
46 INT22558 Gene_expression of COL3A1 10 0.78 7.22 1.36
47 INT129619 Phosphorylation of Smad2 34 0.61 11.6 1.34
48 INT319724 Binding of Crebbp 1 0.16 4.19 1.34
49 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29
50 INT74443 Positive_regulation of PML 11 0.53 12.52 1.21
51 INT99389 Negative_regulation of Ctnnb1 8 0.45 3.97 1.21
52 INT70821 Positive_regulation of Ep300 4 0.25 1.47 1.2
53 INT310164 Negative_regulation of Gene_expression of Tgfbr1 9 0.40 6.11 1.17
54 INT234422 Gene_expression of PML 14 0.75 15.93 1.14
55 INT96424 Transcription of Bmp2 6 0.69 6.34 1.11
56 INT184720 Negative_regulation of Smad3 8 0.55 5.23 1.1
57 INT101104 Positive_regulation of Gene_expression of COL1A2 12 0.69 5.87 1.09
58 INT46734 Positive_regulation of Stub1 6 0.16 1.44 1.09
59 INT160538 Binding of Bmp2 4 0.40 2.08 1.07
60 INT182285 Positive_regulation of Positive_regulation of COL5A2 2 0.13 0.37 1.07
61 INT101570 Positive_regulation of Gene_expression of Ctnnb1 1 0.58 5.7 1.07
62 INT61643 Gene_expression of ACVRL1 9 0.51 9.04 1.03
63 INT133102 Negative_regulation of Gene_expression of COL1A2 8 0.08 2.56 1.02
64 INT167650 Binding of Ep300 1 0.09 0.14 1
65 INT13696 Regulation of COL3A1 2 0.45 2.97 0.95
66 INT34978 Negative_regulation of Gene_expression of Hmga2 2 0.42 1.53 0.95
67 INT155867 Transcription of COL1A2 8 0.69 2.9 0.94
68 INT230251 Binding of FKBP1A 6 0.28 2.24 0.94
69 INT117880 Negative_regulation of Crebbp 3 0.38 0.69 0.94
70 INT114922 Phosphorylation of Crebbp 2 0.21 0.92 0.94
71 INT218696 Negative_regulation of Phosphorylation of Smad2 3 0.42 4.36 0.92
72 INT114664 Binding of BMP2 12 0.37 6.54 0.91
73 INT204547 Positive_regulation of Gene_expression of Col1a2 2 0.04 2.08 0.91
74 INT101566 Negative_regulation of Gene_expression of Ctnnb1 1 0.35 2.28 0.88
75 INT265313 Positive_regulation of Tgfbr1 8 0.66 2.95 0.87
76 INT61642 Binding of ACVRL1 5 0.31 7.03 0.87
77 INT107939 Regulation of TGFBR2 1 0.37 0.98 0.84
78 INT140794 Gene_expression of Smad3 22 0.64 9.41 0.83
79 INT311884 Negative_regulation of Acvrl1 1 0.30 2.16 0.81
80 INT267095 Regulation of Gene_expression of Smad2 3 0.44 1.77 0.8
81 INT265328 Positive_regulation of Acvrl1 5 0.40 3.18 0.78
82 INT161947 Positive_regulation of TGFBR1 2 0.52 1.6 0.76
83 INT137007 Gene_expression of SMAD2 6 0.75 2.53 0.75
84 INT114956 Gene_expression of CREBBP 5 0.31 1.56 0.75
85 INT74097 Gene_expression of Ep300 6 0.52 1.89 0.73
86 INT69914 Binding of PURA 1 0.29 0.1 0.73
87 INT265318 Negative_regulation of Gene_expression of Smad2 8 0.26 2.16 0.72
88 INT262726 Localization of PML 6 0.57 7.13 0.72
89 INT172960 Negative_regulation of Gene_expression of Smad4 7 0.39 5.88 0.71
90 INT91384 Positive_regulation of Localization of COL1A2 3 0.49 1.42 0.71
91 INT156138 Negative_regulation of Gene_expression of Col1a2 2 0.55 2.07 0.7
92 INT269896 Positive_regulation of Gene_expression of Smad2 9 0.40 2.15 0.69
93 INT104305 Binding of COL3A1 2 0.35 3.45 0.68
94 INT137009 Negative_regulation of Gene_expression of SMAD2 4 0.42 1.76 0.66
95 INT125709 Positive_regulation of Gene_expression of Col3a1 7 0.27 5.17 0.65
96 INT268377 Phosphorylation of SMAD2 7 0.80 0.85 0.65
97 INT88987 Gene_expression of HMGA2 8 0.77 10.46 0.64
98 INT22556 Positive_regulation of Gene_expression of COL3A1 5 0.37 4.25 0.64
99 INT99390 Regulation of Ctnnb1 4 0.62 3.12 0.64
100 INT11890 Protein_catabolism of COL3A1 2 0.77 2.41 0.64
101 INT302664 Positive_regulation of SMAD2 2 0.49 0.85 0.64
102 INT101177 Regulation of COL5A2 12 0.45 4.03 0.62
103 INT114955 Positive_regulation of Gene_expression of CREBBP 2 0.23 0.24 0.61
104 INT174540 Positive_regulation of Localization of COL5A2 2 0.04 2.44 0.6
105 INT196939 Gene_expression of Stub1 10 0.18 1.67 0.59
106 INT238049 Positive_regulation of Gene_expression of BMP2 8 0.51 2.06 0.59
107 INT180967 Negative_regulation of Protein_catabolism of COL5A2 4 0.05 1.45 0.59
108 INT144922 Gene_expression of TGFBR1 4 0.72 0.19 0.57
109 INT3831 Negative_regulation of TGFBR2 4 0.28 4.99 0.55
110 INT103781 Negative_regulation of Smad4 9 0.42 4.42 0.54
111 INT138429 Negative_regulation of Gene_expression of Col3a1 3 0.17 2.51 0.54
112 INT182835 Phosphorylation of Crebbp 2 0.26 0.78 0.54
113 INT117879 Regulation of Crebbp 1 0.24 0 0.54
114 INT180966 Positive_regulation of Protein_catabolism of COL5A2 7 0.06 4.55 0.53
115 INT76960 Negative_regulation of Ctnnb1 5 0.57 3.46 0.53
116 INT182836 Positive_regulation of Crebbp 2 0.21 0.76 0.53
117 INT242093 Negative_regulation of Positive_regulation of COL5A2 1 0.08 0 0.53
118 INT129999 Protein_catabolism of Col1a2 3 0.96 1.21 0.52
119 INT85808 Localization of BMP2 7 0.77 1.94 0.51
120 INT158889 Gene_expression of Smad2 5 0.65 1.25 0.51
121 INT89258 Localization of STUB1 3 0.14 0.67 0.49
122 INT88170 Positive_regulation of HMGA2 2 0.69 2 0.48
123 INT244797 Gene_expression of Skor1 1 0.65 0.26 0.48
124 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48
125 INT81645 Positive_regulation of Gene_expression of Ctnnb1 6 0.63 3.78 0.47
126 INT209013 Regulation of Stub1 1 0.06 0.29 0.46
127 INT210125 Regulation of Axin1 1 0.02 2.45 0.46
128 INT92684 Positive_regulation of Col3a1 5 0.56 1.79 0.45
129 INT203478 Gene_expression of Crebbp 3 0.46 2.15 0.44
130 INT71019 Negative_regulation of SMAD4 12 0.42 6.88 0.43
131 INT120086 Gene_expression of Bmp2 5 0.27 2.34 0.43
132 INT125708 Negative_regulation of Col3a1 2 0.16 1.37 0.42
133 INT76958 Positive_regulation of Ctnnb1 14 0.64 5.48 0.41
134 INT173582 Negative_regulation of Localization of COL5A2 6 0.05 3.24 0.41
135 INT95872 Localization of Ctnnb1 7 0.74 2.75 0.4
136 INT314126 Positive_regulation of Gene_expression of Prdm16 4 0.67 4.57 0.4
137 INT319725 Positive_regulation of Binding of Crebbp 1 0.17 1.12 0.4
138 INT292484 Negative_regulation of TGFBR1 3 0.19 0.75 0.39
139 INT63550 Positive_regulation of Protein_catabolism of COL1A2 4 0.25 3.22 0.38
140 INT120899 Positive_regulation of Gene_expression of Tgfbr2 1 0.29 0.46 0.38
141 INT218691 Phosphorylation of Smad3 1 0.28 3 0.38
142 INT117564 Gene_expression of SMAD4 12 0.71 8.7 0.37
143 INT81644 Regulation of Ctnnb1 5 0.41 3.38 0.37
144 INT81643 Regulation of Gene_expression of Ctnnb1 3 0.57 1.5 0.37
145 INT311889 Negative_regulation of Gene_expression of Acvrl1 1 0.22 1.27 0.37
146 INT257288 Regulation of Gene_expression of COL5A2 7 0.21 2.52 0.36
147 INT84945 Transcription of BMP2 5 0.61 1.8 0.36
148 INT157804 Phosphorylation of Smad3 18 0.77 8.15 0.35
149 INT196026 Positive_regulation of Gene_expression of Bmp2 14 0.69 3.19 0.35
150 INT88167 Negative_regulation of Positive_regulation of HMGA2 1 0.41 0.16 0.35
151 INT254816 Negative_regulation of Tgfbr1 20 0.55 9.24 0.34
152 INT187587 Binding of Ep300 11 0.35 2.37 0.34
153 INT207064 Gene_expression of Fkbp1a 2 0.32 1.52 0.34
154 INT130739 Binding of Col1a2 2 0.35 2.38 0.34
155 INT155865 Positive_regulation of Transcription of COL1A2 2 0.46 0.6 0.34
156 INT69910 Positive_regulation of PURA 1 0.25 0.1 0.34
157 INT69921 Positive_regulation of Binding of PURA 1 0.26 0.1 0.34
158 INT342781 Negative_regulation of Gene_expression of Prdm16 1 0.02 0.97 0.34
159 INT207065 Localization of Fkbp1a 1 0.36 0.82 0.33
160 INT65208 Positive_regulation of Positive_regulation of COL1A2 3 0.14 2.63 0.32
161 INT144854 Gene_expression of STUB1 10 0.13 2.03 0.31
162 INT108324 Negative_regulation of Gene_expression of Ctnnb1 1 0.06 1.43 0.31
163 INT92100 Binding of Smad4 5 0.31 2.23 0.3
164 INT129908 Positive_regulation of Smad2 5 0.45 2.13 0.3
165 INT140795 Positive_regulation of Gene_expression of Smad3 3 0.48 3.16 0.3
166 INT137008 Positive_regulation of Gene_expression of SMAD2 2 0.49 0.51 0.3
167 INT17138 Positive_regulation of Skil 2 0.35 0.59 0.3
168 INT157605 Localization of COL3A1 3 0.80 0.55 0.29
169 INT179809 Regulation of Col3a1 2 0.25 0.1 0.29
170 INT224877 Positive_regulation of Gene_expression of Smad2 1 0.12 0.16 0.29
171 INT311895 Regulation of Positive_regulation of Acvrl1 1 0.23 0.97 0.29
172 INT311881 Regulation of Positive_regulation of Tgfbr1 1 0.22 0.97 0.29
173 INT88988 Positive_regulation of Gene_expression of HMGA2 1 0.69 4.05 0.29
174 INT190676 Binding of Fkbp1a 15 0.36 3.11 0.28
175 INT202802 Regulation of Fkbp1a 4 0.26 0.96 0.28
176 INT196937 Positive_regulation of Hmga2 3 0.68 2.47 0.28
177 INT139741 Positive_regulation of Gene_expression of ACVRL1 2 0.38 1.33 0.28
178 INT336951 Positive_regulation of Binding of PML 1 0.09 2.02 0.28
179 INT172978 Negative_regulation of SMAD2 4 0.42 0.89 0.27
180 INT144855 Positive_regulation of STUB1 3 0.08 0.59 0.26
181 INT69919 Regulation of PURA 1 0.37 0.1 0.26
182 INT289317 Positive_regulation of Localization of PML 1 0.23 1.09 0.26
183 INT319719 Negative_regulation of Binding of Crebbp 1 0.14 0.51 0.26
184 INT257283 Negative_regulation of Negative_regulation of COL5A2 2 0.03 1.41 0.25
185 INT179798 Regulation of Gene_expression of Col3a1 2 0.22 0.57 0.25
186 INT262797 Regulation of Gene_expression of Smad3 2 0.34 2.27 0.25
187 INT292362 Negative_regulation of Gene_expression of Col3a1 1 0.10 1.01 0.25
188 INT145305 Positive_regulation of Bmp2 12 0.69 8.65 0.24
189 INT181913 Positive_regulation of Binding of COL5A2 3 0.16 1.06 0.24
190 INT278513 Regulation of Localization of PML 1 0.34 1.73 0.24
191 INT325492 Regulation of Ep300 1 0.04 0.29 0.24
192 INT151719 Negative_regulation of Positive_regulation of Ctnnb1 1 0.23 1.9 0.24
193 INT109699 Regulation of BMP2 5 0.43 2.21 0.23
194 INT221770 Positive_regulation of Phosphorylation of Crebbp 1 0.14 0.21 0.23
195 INT129907 Regulation of Smad2 1 0.40 0.87 0.23
196 INT265311 Localization of Smad2 5 0.50 1.57 0.21
197 INT302405 Transcription of Col1a2 3 0.55 1.82 0.21
198 INT212536 Negative_regulation of COL3A1 2 0.57 3.53 0.21
199 INT203471 Localization of Stub1 1 0.23 0.5 0.21
200 INT96582 Negative_regulation of Protein_catabolism of COL1A2 1 0.37 0.2 0.21
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