GO:0046456

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Name icosanoid biosynthetic process
Categary Process
Go Slim No
Go Link GO:0046456
Unique Molecular Interactions 33
Total Molecular Interactions 34
Total Single Events 570
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for icosanoid biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for icosanoid biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91350 Binding of Pla2g4a and RYBP 1 0.00 1.15 2.65
2 INT126639 KNG1 Positive_regulation of Alox15 1 0.17 0.62 1.36
3 INT126640 Negative_regulation of KNG1 Positive_regulation of Alox15 1 0.14 0.62 1.36
4 INT317559 Binding of Hint1 and Pla2g4a 1 0.01 0.06 0.94
5 INT270218 P2rx3 Positive_regulation of Pla2g4a 1 0.34 0.63 0.85
6 INT231390 Pla2g4a Regulation of Pla2g2a 1 0.08 0.92 0.77
7 INT231388 Pla2g4a Regulation of Pla2g6 1 0.08 0.92 0.77
8 INT308484 Car2 Positive_regulation of Pla2g4a 1 0.03 1.23 0.65
9 INT172144 IL4 Negative_regulation of Transcription of PLA2G4A 1 0.02 0.82 0.58
10 INT248146 PLA2G6 Negative_regulation of Phosphorylation of PLA2G4A 1 0.07 0.72 0.4
11 INT270220 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Pla2g4a 1 0.13 1 0.36
12 INT262354 TRIP10 Negative_regulation of Cyp4a3 1 0.00 0.8 0.26
13 INT336379 TIMP1 Negative_regulation of FADS1 1 0.01 0.52 0.2
14 INT146744 Binding of NR3C1 and PLA2G4A 1 0.26 0.25 0.15
15 INT334770 Ednra Positive_regulation of Pla2g4a 1 0.00 0.24 0.14
16 INT146743 Positive_regulation of Binding of GSR and PLA2G4A 1 0.40 0.14 0.11
17 INT146742 Binding of GSR and PLA2G4A 1 0.28 0.14 0.11
18 INT327557 Pla2g4a Positive_regulation of Phosphorylation of Ptgs2 1 0.14 1.03 0.1
19 INT327559 Pla2g4a Positive_regulation of Gene_expression of Ptgs2 1 0.14 1 0.09
20 INT197776 Pla2g10 Regulation of Pla2g4a 1 0.18 0.61 0.08
21 INT234606 Tlr4 Positive_regulation of Transcription of PLA2G4A 1 0.57 0 0.06
22 INT249199 CA2 Positive_regulation of PLA2G4A 1 0.15 0 0.04
23 INT195837 Tlr4 Positive_regulation of Pla2g4a 1 0.01 0.44 0.03
24 INT348362 Binding of C2 and Positive_regulation of Localization of PLA2G4A 1 0.02 0.37 0.03
25 INT281266 Binding of INS and Cyp4a3 1 0.01 0.42 0
26 INT249179 PLA2G4A Regulation of CYBB 1 0.18 0 0
27 INT249191 CYBB Positive_regulation of PLA2G4A 1 0.20 0 0
28 INT249187 Binding of CYBB and PLA2G4A 1 0.14 0 0
29 INT251965 Binding of HSD11B1 and FADS1 1 0.16 0.37 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for icosanoid biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in icosanoid biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113399 Positive_regulation of Pla2g4a 36 0.67 33.83 18.78
2 INT187513 Positive_regulation of Pla2g4a 5 0.62 34.09 18.22
3 INT195831 Phosphorylation of Pla2g4a 15 0.74 34.43 17.14
4 INT270238 Localization of Pla2g4a 1 0.72 17.99 11.35
5 INT86813 Gene_expression of Pla2g4a 26 0.75 42.31 10.07
6 INT64864 Gene_expression of PLA2G4A 18 0.77 10.45 4.09
7 INT162125 Gene_expression of Pla2g4a 4 0.54 7.69 3.75
8 INT270224 Positive_regulation of Positive_regulation of Pla2g4a 1 0.62 6.63 3.22
9 INT126172 Negative_regulation of Pla2g4a 7 0.39 9.01 2.89
10 INT93207 Negative_regulation of Cyp4a3 11 0.36 4.32 2.63
11 INT122376 Localization of Pla2g4a 12 0.73 7.18 2.58
12 INT270235 Negative_regulation of Phosphorylation of Pla2g4a 1 0.39 3.4 2.34
13 INT17961 Regulation of Pla2g4a 9 0.25 4.86 2.3
14 INT152076 Negative_regulation of Pla2g4a 3 0.55 3.22 2.21
15 INT86814 Transcription of Pla2g4a 4 0.49 2.35 2.14
16 INT195828 Positive_regulation of Phosphorylation of Pla2g4a 3 0.45 5.05 2.12
17 INT91773 Positive_regulation of PLA2G4A 10 0.50 4.4 1.54
18 INT91764 Positive_regulation of Gene_expression of PLA2G4A 8 0.69 5.43 1.52
19 INT270223 Negative_regulation of Localization of Pla2g4a 1 0.39 1.83 1.5
20 INT126635 Negative_regulation of Alox15 2 0.41 0.67 1.43
21 INT268619 Phosphorylation of Pla2g4a 5 0.69 2.14 1.36
22 INT86812 Negative_regulation of Transcription of Pla2g4a 1 0.13 0.49 1.18
23 INT79780 Gene_expression of Cyp4a3 14 0.56 5.19 1.12
24 INT64863 Localization of PLA2G4A 9 0.44 3.33 1.07
25 INT195832 Regulation of Phosphorylation of Pla2g4a 3 0.34 2.91 1.02
26 INT162126 Positive_regulation of Gene_expression of Pla2g4a 4 0.42 2.52 1.01
27 INT80047 Regulation of Cyp4a3 5 0.45 2.11 1
28 INT65166 Negative_regulation of PLA2G4A 7 0.57 1.55 0.96
29 INT86816 Negative_regulation of Gene_expression of Pla2g4a 3 0.50 2.27 0.93
30 INT270236 Regulation of Localization of Pla2g4a 1 0.24 1.68 0.93
31 INT270231 Regulation of Positive_regulation of Pla2g4a 1 0.24 1.92 0.92
32 INT205888 Positive_regulation of Gene_expression of Pla2g4a 7 0.67 8 0.9
33 INT168990 Positive_regulation of Positive_regulation of Pla2g4a 2 0.43 2.14 0.86
34 INT77928 Binding of Pla2g4a 3 0.10 2.5 0.84
35 INT270226 Negative_regulation of Positive_regulation of Pla2g4a 1 0.38 2.34 0.84
36 INT146746 Transcription of PLA2G4A 3 0.69 1.03 0.8
37 INT113400 Positive_regulation of Transcription of Pla2g4a 1 0.08 0.96 0.7
38 INT308475 Regulation of Positive_regulation of Pla2g4a 1 0.09 1.14 0.67
39 INT270227 Positive_regulation of Localization of Pla2g4a 1 0.45 1.31 0.56
40 INT78775 Regulation of PLA2G4A 4 0.25 1.45 0.55
41 INT76858 Binding of PLA2G4A 4 0.30 1.22 0.52
42 INT270229 Binding of Pla2g4a 1 0.29 1.23 0.45
43 INT50467 Localization of Cyp4a3 1 0.61 0.4 0.38
44 INT248153 Phosphorylation of PLA2G4A 1 0.20 0.65 0.38
45 INT126173 Negative_regulation of Regulation of Pla2g4a 1 0.40 1.01 0.37
46 INT126174 Positive_regulation of Regulation of Pla2g4a 1 0.37 1.03 0.34
47 INT205894 Regulation of Gene_expression of Pla2g4a 3 0.52 1.9 0.33
48 INT146747 Negative_regulation of Gene_expression of PLA2G4A 1 0.43 0.66 0.33
49 INT125419 Positive_regulation of Cyp4a3 5 0.18 2.05 0.27
50 INT126171 Negative_regulation of Positive_regulation of Pla2g4a 1 0.39 0.91 0.27
51 INT312523 Negative_regulation of Phosphorylation of Pla2g4a 1 0.16 0.68 0.22
52 INT347963 Binding of Cyp4a3 1 0.01 0.46 0.21
53 INT312522 Positive_regulation of Phosphorylation of Pla2g4a 1 0.14 0.68 0.21
54 INT251969 Negative_regulation of FADS1 2 0.43 0.52 0.2
55 INT146748 Positive_regulation of Transcription of PLA2G4A 1 0.50 0.22 0.17
56 INT195826 Negative_regulation of Gene_expression of Pla2g4a 1 0.28 1.38 0.15
57 INT195829 Regulation of Pla2g4a 1 0.20 2.54 0.15
58 INT84395 Protein_catabolism of Pla2g4a 1 0.02 0.41 0.12
59 INT164778 Regulation of Gene_expression of Cyp4a3 1 0.45 0.5 0.09
60 INT164776 Negative_regulation of Gene_expression of Cyp4a3 1 0.31 0.51 0.09
61 INT150030 Negative_regulation of Gene_expression of Alox15 1 0.11 0.05 0.07
62 INT253445 Positive_regulation of Binding of Pla2g4a 1 0.12 0.91 0.06
63 INT249275 Positive_regulation of Localization of PLA2G4A 1 0.25 0 0.04
64 INT150029 Gene_expression of Alox15 1 0.18 0 0.04
65 INT251970 Positive_regulation of FADS1 1 0.69 0.06 0.03
66 INT143410 Regulation of Localization of PLA2G4A 2 0.34 0 0
67 INT195830 Regulation of Regulation of Pla2g4a 1 0.20 0.62 0
68 INT279942 Gene_expression of FADS1 1 0.69 2.5 0
69 INT251973 Localization of FADS1 1 0.75 0.73 0
70 INT337080 Positive_regulation of Localization of Pla2g4a 1 0.18 1 0
71 INT251974 Binding of FADS1 1 0.36 0 0
72 INT279938 Negative_regulation of Gene_expression of FADS1 1 0.38 1.49 0
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