GO:0046483

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Name heterocycle metabolic process
Categary Process
Go Slim No
Go Link GO:0046483
Unique Molecular Interactions 193
Total Molecular Interactions 249
Total Single Events 2958
Pain Genes Associated 12

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for heterocycle metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for heterocycle metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
2 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
3 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
4 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 0.14 0.89 1.98
5 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
6 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
7 INT123899 Binding of CYP3A4 and UGT2B7 1 0.52 0 1.46
8 INT90221 Binding of CYP2D6 and Cyp1a2 1 0.03 0.09 1.31
9 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09
10 INT28186 CYP2E1 Regulation of Positive_regulation of RYBP 1 0.04 0.33 1.08
11 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08
12 INT77083 Das Negative_regulation of Cyp2e1 1 0.20 0.59 1.06
13 INT154237 Binding of CYP2D6 and Ugt2b7 1 0.41 0.75 1
14 INT53750 Cyp2e1 Positive_regulation of RYBP 1 0.14 0.44 0.99
15 INT52806 CYP2E1 Positive_regulation of RYBP 1 0.43 0.24 0.95
16 INT56274 RYBP Negative_regulation of Cyp2e1 1 0.01 0.17 0.9
17 INT56273 RYBP Negative_regulation of Cyp1a2 1 0.01 0.17 0.9
18 INT56275 RYBP Positive_regulation of Negative_regulation of Cyp1a2 1 0.01 0.17 0.81
19 INT102630 Cyp3a62 Negative_regulation of Cyp1a2 1 0.40 0 0.81
20 INT100783 Binding of CYP2B6 and CYP3A4 2 0.17 2 0.77
21 INT56272 Cyp2e1 Positive_regulation of Cyp1a2 1 0.52 0.17 0.77
22 INT88921 Positive_regulation of CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
23 INT88922 CYP2D6 Negative_regulation of ANTXR1 1 0.00 0.8 0.75
24 INT92370 Binding of CYP2B6 and CYP2D6 1 0.21 0 0.73
25 INT28184 Binding of CYP1A2 and CYP2D6 1 0.00 0 0.7
26 INT76026 Binding of Cyp2e1 and Cyp3a11 1 0.28 0.42 0.64
27 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63
28 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62
29 INT149929 Cyp2e1 Positive_regulation of Gene_expression of Ros1 1 0.12 0 0.61
30 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59
31 INT102670 Cyp2e1 Regulation of RYBP 1 0.01 0 0.58
32 INT102671 Cyp1a2 Regulation of RYBP 1 0.00 0 0.58
33 INT102666 Cyp2e1 Regulation of Cyp1a2 1 0.20 0 0.58
34 INT147575 Binding of Ahr and Cyp1a1 2 0.15 0.15 0.54
35 INT147579 Binding of ATF4 and Cyp1a1 1 0.01 0.15 0.54
36 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5
37 INT92803 Binding of CYP1A2 and VKORC1 1 0.31 0.12 0.48
38 INT92804 Positive_regulation of Binding of CYP1A2 and VKORC1 1 0.41 0.12 0.48
39 INT123897 Binding of CYP3A4 and SLC35A2 1 0.39 0 0.45
40 INT123898 CYP3A4 Regulation of UGT2B7 1 0.22 0 0.41
41 INT69467 CYP2E1 Positive_regulation of Localization of CYP3A 1 0.30 0 0.36
42 INT69469 CYP2E1 Positive_regulation of CYP2B6 1 0.36 0 0.36
43 INT132984 CYP3A4 Positive_regulation of Gene_expression of PPP4C 1 0.44 0 0.3
44 INT335134 PPARA Negative_regulation of Cyp1a1 1 0.47 0 0.28
45 INT169146 CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
46 INT169145 Regulation of CYP2D6 Regulation of CYP3A 1 0.22 0 0.27
47 INT130678 CYP2C9 Regulation of Cyp1a2 1 0.06 0 0.26
48 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26
49 INT262329 TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26
50 INT262330 Positive_regulation of TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26
51 INT262227 Nr1h4 Regulation of Transcription of CYP3A4 1 0.08 0.12 0.26
52 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25
53 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25
54 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25
55 INT130663 Cyp1a2 Regulation of Binding of Ugt2b7 1 0.12 0 0.25
56 INT262229 Binding of CYP3A4 and Casr 1 0.03 0.37 0.24
57 INT57171 Binding of RYBP and Cyp1a1 1 0.01 0 0.23
58 INT115729 Binding of CYP3A7 and CYP3A4 1 0.44 0.05 0.23
59 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22
60 INT100823 Cyp2e1 Positive_regulation of Ros1 1 0.35 1.22 0.22
61 INT20310 Binding of Hnf1a and Positive_regulation of Transcription of Cyp2e1 1 0.02 0 0.21
62 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2
63 INT57964 Myo5a Regulation of Negative_regulation of Cyp1a1 1 0.00 0.1 0.2
64 INT262224 Sfn Negative_regulation of Transcription of CYP3A4 1 0.06 0.58 0.2
65 INT125550 FGFR1 Negative_regulation of Cyp2e1 1 0.02 0.06 0.18
66 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18
67 INT301615 Binding of Cyp2e1 and Samsn1 1 0.02 2.42 0.18
68 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18
69 INT151895 Binding of CYP3A4 and GBE1 1 0.01 0.24 0.18
70 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18
71 INT104379 Gh1 Regulation of CYP2D6 1 0.07 0 0.17
72 INT85828 CYP3A4 Negative_regulation of CYP2D6 1 0.47 0.06 0.16
73 INT134196 Ahr Regulation of Transcription of Cyp1a1 1 0.11 0.14 0.16
74 INT151894 NR1I2 Positive_regulation of CYP3A4 1 0.19 0.23 0.16
75 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15
76 INT262231 Sfn Negative_regulation of Gene_expression of CYP3A4 1 0.06 0.26 0.14
77 INT262232 Nr1i2 Positive_regulation of Gene_expression of CYP3A4 1 0.17 0.26 0.14
78 INT343027 Binding of CYP3A4 and Azi1 1 0.02 0.75 0.14
79 INT57170 Binding of Cyp1a1 and Cyp2b1 1 0.39 0 0.13
80 INT125551 Binding of FGFR1 and Cyp2e1 1 0.02 0.07 0.13
81 INT262228 Nr1i2 Positive_regulation of Transcription of CYP3A4 1 0.17 0.27 0.13
82 INT262226 Positive_regulation of Nr1i2 Positive_regulation of CYP3A4 1 0.17 0.68 0.12
83 INT97082 CYP2D6 Regulation of HAGH 1 0.02 0 0.11
84 INT97081 CYP3A4 Regulation of HAGH 1 0.02 0 0.11
85 INT97080 CYP2E1 Regulation of HAGH 1 0.02 0 0.11
86 INT155221 Binding of CYP3A4 and PNPLA4 1 0.09 0 0.1
87 INT134201 Positive_regulation of Binding of AHR and Cyp1a1 1 0.21 0.07 0.1
88 INT134200 Binding of AHR and Cyp1a1 1 0.16 0.07 0.1
89 INT264085 CYP2C19 Regulation of CYP3A4 1 0.02 0 0.09
90 INT264103 Cyp2e1 Regulation of CYP2C9 1 0.04 0 0.09
91 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09
92 INT162507 Gtf3a Regulation of CYP1A2 1 0.00 0.09 0.09
93 INT264104 Cyp1a2 Regulation of CYP2C9 1 0.04 0 0.09
94 INT264083 CYP2C19 Regulation of CYP2D6 1 0.05 0 0.09
95 INT177296 Binding of CXADR and CYP3A4 1 0.30 0 0.09
96 INT264084 CYP2C19 Regulation of CYP2C9 1 0.03 0 0.09
97 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09
98 INT264107 Cyp2e1 Regulation of CYP2D6 1 0.05 0 0.09
99 INT264105 Cyp2e1 Regulation of CYP3A4 1 0.02 0 0.09
100 INT99476 Binding of CYP3A4 and ABCB1 2 0.28 0 0.08
101 INT219661 Binding of CYP2D6 and CYP2E1 1 0.30 0.22 0.08
102 INT177265 Binding of CYP3A4 and NR1H4 1 0.03 0 0.08
103 INT57965 Myo5a Negative_regulation of Cyp2e1 1 0.01 0.09 0.07
104 INT168368 Binding of Cyp1a2 and Cyp2e1 1 0.37 0.08 0.07
105 INT22568 Cyp1a1 Positive_regulation of Tcf21 1 0.04 0 0.06
106 INT22567 Cyp1a2 Positive_regulation of Tcf21 1 0.04 0 0.06
107 INT145626 Binding of PKLR and UGT1A1 1 0.02 0 0.06
108 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06
109 INT264568 Binding of STS and CYP1A2 1 0.20 0.18 0.06
110 INT342221 Cyp2e1 Positive_regulation of Gene_expression of TRNAI1 1 0.03 0.22 0.05
111 INT339695 Binding of CYP3A4 and TRO 1 0.06 0.57 0.05
112 INT319578 CYP3A4 Regulation of ALPPL2 1 0.00 0.56 0.05
113 INT180373 CYP2A6 Regulation of Cyp2d4 1 0.05 2.01 0.05
114 INT180372 CYP2A6 Regulation of Cyp1a2 1 0.03 2.02 0.05
115 INT177274 Binding of CYP3A4 and TNFRSF25 1 0.19 0 0.04
116 INT177273 Binding of CYP3A4 and FAUP1 1 0.02 0 0.04
117 INT339707 TRO Positive_regulation of CYP3A4 1 0.12 0.97 0.04
118 INT199406 Binding of CYP3A4 and PPIB 1 0.40 0 0.04
119 INT285385 Ass1 Positive_regulation of Transcription of Cyp1a2 1 0.00 0.09 0.03
120 INT125643 Cyp2e1 Positive_regulation of Transcription of Cyp2c11 1 0.51 0 0
121 INT125656 Cyp2e1 Positive_regulation of Transcription of Cyp2b2 1 0.07 0 0
122 INT294894 CYP3A4 Negative_regulation of CYP2C19 1 0.08 0.13 0
123 INT301640 Positive_regulation of Cyp2e1 Positive_regulation of Gene_expression of Ros1 1 0.03 0.25 0
124 INT125646 Cyp2b2 Positive_regulation of Transcription of Cyp2e1 1 0.07 0 0
125 INT96893 Binding of CYP3A4 and Orm2 1 0.07 0 0
126 INT262225 Binding of CYP3A4 and Nr1i2 1 0.13 0 0
127 INT20322 Binding of CYP1A2 and CYP26A1 1 0.00 0 0
128 INT96894 Binding of CYP3A4 and Orm1 1 0.00 0 0
129 INT135130 Binding of CYP3A4 and NR1I2 1 0.34 0.31 0
130 INT199717 2610029G23Rik Regulation of CYP2D6 1 0.02 0.44 0
131 INT125652 Cyp2c6 Positive_regulation of Transcription of Cyp2e1 1 0.49 0 0
132 INT210417 APOB Negative_regulation of CYP2D6 1 0.01 0 0
133 INT294895 CYP3A4 Negative_regulation of CYP2C9 1 0.09 0.13 0
134 INT177290 GOPC Positive_regulation of CYP3A4 1 0.15 0 0
135 INT20325 Binding of CYP2D6 and CYP21A2 1 0.00 0 0
136 INT199718 2610029G23Rik Regulation of CYP2C19 1 0.03 0.44 0
137 INT20326 Binding of CYP1A2 and CYP21A2 1 0.01 0 0
138 INT339700 CYP2B6 Positive_regulation of CYP3A4 1 0.13 0.3 0
139 INT125650 Cyp2e1 Positive_regulation of Transcription of Cyp2c6 1 0.49 0 0
140 INT125661 Cyp2c11 Positive_regulation of Transcription of Cyp2e1 1 0.51 0 0
141 INT197295 Positive_regulation of Binding of Ahr and Cyp1a1 1 0.20 0 0
142 INT53286 Binding of CYP1A2 and OPN1LW 1 0.03 0 0
143 INT199711 2610029G23Rik Regulation of Cyp2e1 1 0.03 0.45 0
144 INT96892 Negative_regulation of Binding of CYP3A4 and Orm2 1 0.08 0 0
145 INT199719 2610029G23Rik Regulation of CYP3A4 1 0.01 0.45 0
146 INT157283 CYP1A2 Positive_regulation of Gm7100 1 0.00 0 0
147 INT20324 Binding of CYP2D6 and CYP26A1 1 0.00 0 0
148 INT262223 Negative_regulation of Nr1i2 Negative_regulation of Gene_expression of CYP3A4 1 0.21 0.48 0
149 INT96895 Negative_regulation of Binding of CYP3A4 and Orm1 1 0.00 0 0
150 INT168313 Binding of NAT2 and CYP2E1 1 0.21 0.08 0
151 INT135129 NR1I2 Regulation of Transcription of CYP3A4 1 0.58 0.6 0
152 INT125654 Cyp2e1 Positive_regulation of Transcription of Cyp3a23/3a1 1 0.43 0 0
153 INT95055 Binding of CYP1A2 and TXNRD1 1 0.04 0 0
154 INT169147 Binding of CYP2D6 and CYP3A 1 0.17 0 0
155 INT156700 Binding of Crp and UGT1A1 1 0.40 0 0
156 INT20321 Binding of CYP2E1 and CYP21A2 1 0.00 0 0
157 INT20323 Binding of CYP2E1 and CYP26A1 1 0.00 0 0
158 INT210416 ITGA4 Negative_regulation of CYP2D6 1 0.01 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for heterocycle metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in heterocycle metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
2 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
3 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
4 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49
5 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
6 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27
7 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6
8 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22
9 INT47859 Negative_regulation of Cyp2e1 41 0.59 16.92 21.72
10 INT20305 Gene_expression of Cyp2e1 53 0.78 19.75 19.54
11 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35
12 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79
13 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45
14 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35
15 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66
16 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65
17 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43
18 INT53747 Positive_regulation of Cyp2e1 34 0.70 29.03 13.39
19 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31
20 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12
21 INT62580 Gene_expression of Cyp2e1 31 0.78 15.4 11.08
22 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66
23 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21
24 INT47860 Negative_regulation of Cyp1a2 20 0.57 6.06 10
25 INT53746 Regulation of Cyp2e1 11 0.62 3.82 9.52
26 INT57665 Negative_regulation of Cyp2e1 35 0.59 8.05 9.29
27 INT107087 Positive_regulation of Gene_expression of Cyp2e1 20 0.70 8.89 9.04
28 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57
29 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92
30 INT18759 Positive_regulation of Gene_expression of CYP2E1 22 0.70 5.02 6.84
31 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92
32 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73
33 INT185 Regulation of Cyp1a1 18 0.54 2.71 5.56
34 INT62579 Negative_regulation of Gene_expression of Cyp2e1 8 0.59 2.95 5.48
35 INT23952 Gene_expression of Cyp2d4 18 0.78 4.76 5.31
36 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2
37 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18
38 INT2435 Negative_regulation of Cyp1a1 15 0.58 3.32 5.16
39 INT186 Positive_regulation of Cyp1a1 30 0.70 5 5.02
40 INT49292 Positive_regulation of Cyp1a2 17 0.69 6.16 4.96
41 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75
42 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73
43 INT114718 Positive_regulation of Gene_expression of CYP3A4 17 0.49 4.69 4.69
44 INT65514 Gene_expression of Cyp1a2 25 0.77 6.12 4.6
45 INT65881 Gene_expression of CYP2C19 21 0.76 1.19 4.57
46 INT59041 Negative_regulation of CYP2E1 17 0.59 5.47 4.51
47 INT52088 Binding of Cyp2e1 8 0.48 2.5 4.43
48 INT60188 Positive_regulation of Cyp2d4 10 0.70 1.04 4.35
49 INT100262 Positive_regulation of Positive_regulation of Cyp2e1 7 0.50 2.39 4.31
50 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29
51 INT180338 Binding of Cyp2d4 12 0.47 6.87 4.09
52 INT158593 Negative_regulation of Negative_regulation of CYP3A4 5 0.43 1.16 4.01
53 INT20303 Regulation of Cyp2e1 11 0.61 2.46 3.84
54 INT79096 Binding of Cyp2e1 12 0.48 4.41 3.8
55 INT71199 Positive_regulation of Gene_expression of Cyp1a2 4 0.69 1.41 3.36
56 INT71195 Transcription of Cyp1a2 6 0.53 2.41 3.24
57 INT100785 Protein_catabolism of CYP3A4 7 1.00 0.76 3.01
58 INT52084 Localization of Cyp2e1 6 0.71 1.99 2.79
59 INT90960 Positive_regulation of Gene_expression of CYP2D6 9 0.50 2.06 2.76
60 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72
61 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71
62 INT126498 Positive_regulation of Negative_regulation of Cyp1a2 2 0.41 1.21 2.64
63 INT20304 Transcription of Cyp2e1 11 0.70 2.5 2.57
64 INT62653 Positive_regulation of CYP2C19 8 0.54 1.23 2.41
65 INT113081 Negative_regulation of Gene_expression of Cyp1a2 6 0.58 1.68 2.39
66 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38
67 INT180343 Negative_regulation of Negative_regulation of Cyp2d4 2 0.36 0.49 2.38
68 INT56337 Regulation of Cyp1a2 8 0.27 1.09 2.33
69 INT28191 Positive_regulation of Positive_regulation of CYP2E1 5 0.49 3.5 2.25
70 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17
71 INT143686 Negative_regulation of Gene_expression of CYP2D6 4 0.58 0.83 2.16
72 INT9906 Binding of CYP2E1 15 0.40 1.89 2.08
73 INT117898 Positive_regulation of Protein_catabolism of CYP3A4 1 0.67 0 2.08
74 INT99410 Positive_regulation of UGT1A1 10 0.45 2.2 2.07
75 INT28188 Regulation of CYP2E1 11 0.62 0.48 2.03
76 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03
77 INT107091 Regulation of Gene_expression of Cyp2e1 4 0.62 2.17 2.03
78 INT53390 Negative_regulation of Positive_regulation of Cyp1a2 2 0.35 0 2.03
79 INT82722 Negative_regulation of Positive_regulation of Cyp2e1 6 0.59 3.74 2.02
80 INT65424 Positive_regulation of Gene_expression of CYP1A2 6 0.70 2.01 2.01
81 INT53387 Negative_regulation of Positive_regulation of Cyp2e1 3 0.42 1.28 1.98
82 INT19409 Binding of Cyp1a1 12 0.48 2.58 1.97
83 INT82649 Negative_regulation of Gene_expression of Cyp2e1 3 0.58 2.51 1.93
84 INT148944 Transcription of UGT1A1 3 0.59 0.07 1.84
85 INT87095 Positive_regulation of Gene_expression of CYP2C19 3 0.48 0 1.5
86 INT303913 Regulation of Regulation of CYP2D6 2 0.37 1.09 1.48
87 INT78889 Binding of UGT1A1 10 0.47 3.41 1.47
88 INT144738 Regulation of Gene_expression of CYP2D6 3 0.60 0 1.44
89 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38
90 INT17862 Localization of Cyp1a1 5 0.74 0.34 1.34
91 INT93863 Transcription of CYP2E1 3 0.69 1.39 1.34
92 INT117897 Negative_regulation of Protein_catabolism of CYP3A4 1 0.55 0 1.28
93 INT115374 Positive_regulation of Gene_expression of Cyp2e1 6 0.67 4.36 1.27
94 INT13674 Gene_expression of Cyp1a1 13 0.65 2.22 1.25
95 INT123284 Positive_regulation of Positive_regulation of Cyp2e1 3 0.46 2.34 1.22
96 INT145488 Regulation of Cyp2d4 5 0.45 1.1 1.19
97 INT331001 Positive_regulation of Localization of CYP2D6 1 0.48 0.23 1.18
98 INT94396 Regulation of Cyp1a2 4 0.60 0.37 1.15
99 INT72558 Regulation of CYP2C19 6 0.54 1.97 1.14
100 INT134955 Positive_regulation of Transcription of Cyp1a2 2 0.38 0.52 1.14
101 INT165310 Negative_regulation of Transcription of CYP2E1 1 0.42 1.15 1.14
102 INT125541 Transcription of CYP3A4 7 0.69 2.14 1.02
103 INT132623 Transcription of Cyp2e1 2 0.53 0.56 0.98
104 INT79635 Localization of Cyp1a2 2 0.74 0.26 0.97
105 INT56270 Negative_regulation of Binding of Cyp2e1 1 0.42 0.17 0.94
106 INT56271 Positive_regulation of Negative_regulation of Cyp2e1 1 0.46 0.17 0.93
107 INT130671 Regulation of Gene_expression of Cyp1a2 2 0.43 1.27 0.87
108 INT95537 Transcription of CYP2D6 4 0.68 0.2 0.85
109 INT77927 Negative_regulation of Gene_expression of Cyp1a2 3 0.42 1.23 0.78
110 INT149926 Negative_regulation of Negative_regulation of Cyp2e1 1 0.43 0.14 0.78
111 INT149927 Regulation of Negative_regulation of Cyp2e1 1 0.45 0.13 0.78
112 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76
113 INT17868 Localization of Cyp1a2 3 0.75 0.05 0.75
114 INT98177 Negative_regulation of Transcription of Cyp2e1 2 0.40 0.89 0.75
115 INT94193 Transcription of Cyp1a2 4 0.65 1.29 0.74
116 INT94550 Negative_regulation of Gene_expression of CYP2C19 2 0.38 0 0.74
117 INT17865 Regulation of Positive_regulation of Cyp1a2 2 0.45 0 0.74
118 INT20306 Positive_regulation of Transcription of Cyp2e1 2 0.49 0.63 0.73
119 INT168367 Localization of Cyp2e1 2 0.71 0.6 0.72
120 INT331008 Positive_regulation of Localization of CYP1A2 1 0.42 0.06 0.7
121 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69
122 INT79097 Positive_regulation of Binding of Cyp2e1 1 0.50 0.53 0.69
123 INT71188 Binding of Cyp1a2 5 0.44 0.58 0.68
124 INT149928 Positive_regulation of Negative_regulation of Cyp2e1 2 0.50 0.35 0.68
125 INT331002 Negative_regulation of Localization of CYP2D6 1 0.40 0.17 0.6
126 INT115826 Transcription of Cyp1a1 4 0.52 1.15 0.53
127 INT154347 Regulation of Gene_expression of CYP2E1 2 0.27 0.22 0.53
128 INT2438 Regulation of Regulation of Cyp1a1 1 0.27 0 0.52
129 INT163991 Positive_regulation of Regulation of Cyp2e1 1 0.70 0.28 0.52
130 INT142624 Regulation of Negative_regulation of CYP2D6 1 0.27 0 0.51
131 INT199410 Negative_regulation of Binding of CYP3A4 4 0.43 0.96 0.5
132 INT163994 Positive_regulation of Binding of Cyp2e1 2 0.50 0.45 0.5
133 INT330997 Regulation of Positive_regulation of CYP2C19 1 0.35 0.3 0.47
134 INT331000 Regulation of Positive_regulation of CYP2D6 1 0.43 0.3 0.47
135 INT135131 Regulation of Gene_expression of CYP3A4 8 0.59 4.32 0.44
136 INT199409 Positive_regulation of Negative_regulation of CYP3A4 7 0.50 2.54 0.41
137 INT27414 Positive_regulation of Negative_regulation of Cyp1a1 1 0.49 0.44 0.41
138 INT144386 Positive_regulation of Negative_regulation of CYP2D6 3 0.49 1.01 0.4
139 INT115835 Negative_regulation of Positive_regulation of Cyp1a1 2 0.32 1.35 0.36
140 INT84396 Positive_regulation of Positive_regulation of Cyp1a2 2 0.24 0.22 0.34
141 INT155222 Positive_regulation of Transcription of CYP3A4 2 0.50 0.13 0.34
142 INT273509 Positive_regulation of Gene_expression of Cyp1a2 2 0.14 1.2 0.33
143 INT144666 Positive_regulation of Binding of CYP2E1 1 0.50 0.25 0.3
144 INT158581 Negative_regulation of Positive_regulation of CYP3A4 7 0.43 1.83 0.29
145 INT13676 Negative_regulation of Gene_expression of Cyp1a1 1 0.33 0.1 0.29
146 INT71517 Localization of CYP2E1 3 0.75 0 0.28
147 INT144387 Positive_regulation of Negative_regulation of CYP1A2 2 0.39 0.64 0.28
148 INT99628 Positive_regulation of Gene_expression of Cyp1a1 4 0.25 1.3 0.27
149 INT52176 Positive_regulation of Binding of Cyp1a1 1 0.44 0 0.26
150 INT347186 Regulation of Negative_regulation of Cyp2d4 1 0.45 0.21 0.25
151 INT115834 Positive_regulation of Transcription of Cyp1a1 2 0.38 0.64 0.23
152 INT278672 Positive_regulation of Transcription of UGT1A1 1 0.27 0.07 0.22
153 INT17861 Positive_regulation of Localization of Cyp1a2 2 0.50 0.05 0.21
154 INT144389 Positive_regulation of Negative_regulation of CYP2C19 2 0.43 0.37 0.17
155 INT137622 Protein_catabolism of CYP2D6 2 0.38 0 0.17
156 INT344069 Negative_regulation of Binding of CYP2E1 1 0.15 0.05 0.17
157 INT344065 Negative_regulation of Binding of CYP2D6 1 0.15 0.05 0.17
158 INT344068 Negative_regulation of Binding of CYP1A2 1 0.15 0.05 0.17
159 INT134195 Regulation of Transcription of Cyp1a1 1 0.13 0.14 0.16
160 INT85594 Regulation of Gene_expression of CYP2C19 1 0.24 0.06 0.16
161 INT345946 Negative_regulation of Localization of CYP3A4 1 0.09 0.56 0.16
162 INT261231 Negative_regulation of Gene_expression of Cyp2d4 2 0.42 0.36 0.14
163 INT314338 Positive_regulation of Transcription of Cyp1a2 1 0.13 0.38 0.14
164 INT105897 Regulation of UGT1A1 3 0.60 1.6 0.13
165 INT231567 Negative_regulation of Gene_expression of CYP1A2 2 0.36 0.06 0.13
166 INT162937 Regulation of Regulation of CYP1A2 1 0.45 0 0.12
167 INT17866 Positive_regulation of Localization of Cyp1a1 1 0.49 0 0.12
168 INT162936 Regulation of Gene_expression of CYP1A2 1 0.45 0 0.12
169 INT137623 Protein_catabolism of CYP2C19 1 0.37 0 0.11
170 INT113802 Transcription of Cyp2d4 1 0.69 0 0.11
171 INT137619 Protein_catabolism of Cyp1a2 1 0.33 0 0.11
172 INT137620 Protein_catabolism of Cyp2e1 1 0.16 0 0.11
173 INT100094 Regulation of Positive_regulation of CYP3A4 3 0.45 0.31 0.1
174 INT17863 Regulation of Positive_regulation of Cyp1a1 1 0.27 0 0.09
175 INT135458 Negative_regulation of Negative_regulation of Cyp1a2 1 0.35 0.36 0.09
176 INT168366 Positive_regulation of Localization of Cyp2e1 1 0.48 0.05 0.09
177 INT152879 Regulation of Negative_regulation of Cyp2e1 1 0.45 0.8 0.08
178 INT262138 Positive_regulation of Regulation of CYP3A4 1 0.15 0.06 0.07
179 INT351092 Localization of CYP2C19 1 0.26 0 0.07
180 INT278678 Positive_regulation of Gene_expression of UGT1A1 1 0.37 0.09 0.06
181 INT274055 Protein_catabolism of CYP1A2 1 0.47 0 0.06
182 INT73220 Regulation of Gene_expression of Cyp1a2 1 0.62 1.01 0.06
183 INT180329 Positive_regulation of Binding of Cyp2d4 1 0.33 1.97 0.05
184 INT231566 Negative_regulation of Gene_expression of CYP2E1 1 0.25 0 0.05
185 INT306772 Positive_regulation of Negative_regulation of Cyp1a2 1 0.08 0.06 0.04
186 INT191845 Regulation of Negative_regulation of CYP2E1 1 0.45 0.26 0.03
187 INT342207 Regulation of Gene_expression of Cyp2e1 1 0.25 0.51 0.03
188 INT264053 Positive_regulation of Negative_regulation of Cyp2d4 1 0.25 0.18 0.03
189 INT349929 Transcription of CYP2C19 1 0.43 0.2 0.03
190 INT123100 Positive_regulation of Positive_regulation of CYP3A4 2 0.54 0 0
191 INT71516 Protein_catabolism of CYP2E1 1 1.00 0 0
192 INT303488 Negative_regulation of Positive_regulation of Cyp1a2 1 0.18 0.96 0
193 INT222893 Phosphorylation of CYP2E1 1 0.58 1.52 0
194 INT277007 Negative_regulation of Transcription of CYP3A4 1 0.39 0.34 0
195 INT83244 Regulation of Positive_regulation of CYP1A2 1 0.43 1.18 0
196 INT158582 Negative_regulation of Positive_regulation of CYP1A2 1 0.41 0 0
197 INT330999 Negative_regulation of Positive_regulation of CYP2D6 1 0.40 0 0
198 INT349463 Negative_regulation of Gene_expression of UGT1A1 1 0.22 1.05 0
199 INT132624 Negative_regulation of Transcription of Cyp2e1 1 0.40 0.06 0
200 INT85223 Regulation of Localization of Cyp1a1 1 0.03 0.1 0
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