GO:0046498

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Name S-adenosylhomocysteine metabolic process
Categary Process
Go Slim No
Go Link GO:0046498
Unique Molecular Interactions 55
Total Molecular Interactions 82
Total Single Events 659
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for S-adenosylhomocysteine metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for S-adenosylhomocysteine metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
2 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
3 INT261617 SNRNP70 Regulation of Comt 1 0.01 0.4 1.18
4 INT287132 Binding of NT5E and Comt 1 0.03 0.11 0.73
5 INT167455 Binding of MSD and Comt 1 0.15 0.28 0.5
6 INT311616 Binding of MET and Comt 1 0.01 0.2 0.37
7 INT285718 Binding of DNMT3B and Lbp 1 0.08 0.33 0.33
8 INT16382 Binding of Grin1 and Gnmt 1 0.04 0.17 0.32
9 INT130128 Binding of Ocln and Tjp1 2 0.38 0.98 0.29
10 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
11 INT287131 Negative_regulation of Binding of NT5E and Comt 1 0.03 0.06 0.23
12 INT287130 Positive_regulation of Binding of NT5E and Comt 1 0.04 0 0.12
13 INT83827 Negative_regulation of Binding of Adrb1 and Pnmt 1 0.02 0 0.1
14 INT83828 Binding of Adrb1 and Pnmt 1 0.01 0 0.1
15 INT265346 Binding of Ocln and Tjp1 7 0.05 1.11 0.09
16 INT66171 Negative_regulation of Adra2a Negative_regulation of Positive_regulation of Pnmt 1 0.38 0 0.08
17 INT205244 Cldn3 Regulation of Gene_expression of Ocln 1 0.04 0.29 0.07
18 INT205229 Cldn2 Regulation of Gene_expression of Ocln 1 0.07 0.29 0.07
19 INT66166 Negative_regulation of Binding of Pnmt and Adra2a 1 0.38 0 0.07
20 INT205233 Cldn5 Regulation of Gene_expression of Ocln 1 0.03 0.28 0.07
21 INT66167 Negative_regulation of Pnmt Negative_regulation of Adra2a 1 0.38 0 0.07
22 INT66172 Binding of Pnmt and Adra2a 1 0.33 0 0.07
23 INT265564 Ocln Regulation of Gene_expression of Cdh5 1 0.01 1.03 0.05
24 INT228610 Binding of DNMT3B and ASPRV1 1 0.02 0 0.05
25 INT355224 Phosphorylation of Ocln Negative_regulation of Binding of Tjp2 1 0.06 0.09 0.04
26 INT355219 Phosphorylation of Ocln Positive_regulation of Binding of Tjp2 1 0.07 0.09 0.04
27 INT305875 Pcx Negative_regulation of Binding of Ocln 1 0.03 0.11 0.04
28 INT265347 Binding of Ocln and Tgfbr1 1 0.18 0.06 0.03
29 INT265348 Positive_regulation of Binding of Ocln and Tgfbr1 1 0.25 0.06 0.03
30 INT241268 DNMT3B Positive_regulation of Gene_expression of DNMT1 1 0.19 0.67 0
31 INT183412 Dnmt3a Positive_regulation of Tbx15 1 0.05 0.27 0
32 INT355220 Negative_regulation of Binding of Ocln and Tjp1 1 0.21 0.14 0
33 INT305879 Binding of Ocln and Pcx 1 0.03 0 0
34 INT305881 Positive_regulation of Binding of Ocln and Tjp1 1 0.01 0 0
35 INT241266 DNMT3B Positive_regulation of Gene_expression of GOPC 1 0.05 0.68 0
36 INT183413 Dnmt3a Positive_regulation of Gene_expression of Dnmt3b 1 0.10 0.28 0
37 INT241264 DNMT1 Positive_regulation of Gene_expression of DNMT3B 1 0.19 0.67 0
38 INT241257 DNMT3B Positive_regulation of OPCML 1 0.35 0.68 0
39 INT245821 Binding of Ppp2r2b and Ocln 1 0.00 0.81 0
40 INT241259 DNMT3B Positive_regulation of GOPC 1 0.05 0.68 0
41 INT183415 Dnmt3b Positive_regulation of Gene_expression of Dnmt3a 1 0.10 0.28 0
42 INT154023 Binding of NOVA2 and Comt 1 0.03 0.08 0
43 INT297690 Binding of Fut1 and Ocln 1 0.02 0 0
44 INT355221 Binding of Espn and Ocln 1 0.01 0 0
45 INT245832 VEGFA Positive_regulation of Phosphorylation of Ocln 1 0.04 1.61 0
46 INT245830 VEGFA Regulation of Ocln 1 0.02 0.83 0
47 INT253331 Binding of DNMT3B and SP140 1 0.04 0.17 0
48 INT183410 Dnmt3b Positive_regulation of Tbx15 1 0.05 0.27 0
49 INT355225 Binding of Ocln and Tjp2 1 0.07 0 0
50 INT191135 Binding of DNMT3A and DNMT3B 1 0.09 0 0
51 INT355222 Positive_regulation of Binding of Ocln and Tjp1 1 0.18 0 0
52 INT245824 Plg Regulation of Negative_regulation of Ocln 1 0.06 0.57 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for S-adenosylhomocysteine metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in S-adenosylhomocysteine metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT519 Negative_regulation of Comt 52 0.59 17.65 20.39
2 INT18539 Gene_expression of Pnmt 33 0.78 3.08 12.47
3 INT520 Binding of Comt 24 0.48 8.98 12.21
4 INT3922 Negative_regulation of Pnmt 29 0.59 3.18 8.96
5 INT23132 Positive_regulation of Pnmt 17 0.67 2.02 6.84
6 INT50712 Gene_expression of Comt 13 0.68 6.33 6.23
7 INT73117 Positive_regulation of DNMT3B 20 0.47 10.31 5.31
8 INT2162 Regulation of Comt 13 0.60 2.9 5.18
9 INT105284 Gene_expression of Ocln 39 0.78 14.98 5.08
10 INT14455 Transcription of Pnmt 17 0.72 2.13 4.95
11 INT2871 Positive_regulation of Comt 9 0.50 2.8 4.78
12 INT12380 Localization of Pnmt 10 0.80 0.07 4.7
13 INT18538 Regulation of Pnmt 11 0.60 1.03 3.84
14 INT136106 Gene_expression of DNMT3B 30 0.58 8.43 3.7
15 INT121531 Negative_regulation of DNMT3B 13 0.36 3.46 3.05
16 INT133038 Binding of DNMT3B 26 0.40 5.97 2.83
17 INT128983 Protein_catabolism of Comt 5 0.87 0.22 2.6
18 INT28468 Positive_regulation of Transcription of Pnmt 4 0.67 0.63 2.04
19 INT124077 Negative_regulation of Ocln 13 0.57 8.62 1.8
20 INT447 Localization of Comt 4 0.75 0.76 1.8
21 INT28478 Regulation of Gene_expression of Pnmt 5 0.44 0 1.41
22 INT157500 Localization of DNMT3B 12 0.73 2.21 1.38
23 INT105286 Negative_regulation of Gene_expression of Ocln 7 0.31 2.52 1.35
24 INT46336 Regulation of DNMT3B 12 0.53 4.91 1.25
25 INT65165 Positive_regulation of Negative_regulation of Comt 1 0.03 0 1.15
26 INT322088 Regulation of Regulation of DNMT3B 1 0.03 2.74 1.12
27 INT28469 Positive_regulation of Gene_expression of Pnmt 4 0.49 0.73 1.11
28 INT125904 Positive_regulation of Ocln 6 0.45 2.06 1.06
29 INT285716 Negative_regulation of Gene_expression of DNMT3B 1 0.21 0.96 0.96
30 INT47518 Negative_regulation of Positive_regulation of Pnmt 2 0.42 0.32 0.8
31 INT245796 Phosphorylation of Ocln 6 0.33 2.76 0.76
32 INT344931 Positive_regulation of Protein_catabolism of Comt 1 0.49 0 0.76
33 INT12379 Regulation of Localization of Pnmt 1 0.17 0 0.69
34 INT159143 Gene_expression of Ocln 14 0.42 5.25 0.57
35 INT158898 Positive_regulation of Gene_expression of Ocln 5 0.22 2.06 0.57
36 INT241287 Positive_regulation of Gene_expression of DNMT3B 3 0.40 1.21 0.57
37 INT304633 Positive_regulation of Phosphorylation of Ocln 2 0.28 0.19 0.47
38 INT61822 Negative_regulation of Ocln 8 0.41 5.33 0.45
39 INT50711 Regulation of Gene_expression of Comt 2 0.01 0 0.39
40 INT306690 Negative_regulation of Dnmt3b 1 0.00 0.56 0.39
41 INT159145 Negative_regulation of Gene_expression of Ocln 4 0.32 3.07 0.34
42 INT124076 Binding of Ocln 3 0.37 1.01 0.34
43 INT16380 Positive_regulation of Gnmt 1 0.05 0.25 0.33
44 INT205218 Localization of Ocln 3 0.46 1.71 0.32
45 INT287124 Negative_regulation of Protein_catabolism of Comt 1 0.38 0.22 0.29
46 INT83525 Negative_regulation of Transcription of Pnmt 3 0.57 0 0.27
47 INT217515 Binding of Ocln 7 0.22 2.12 0.25
48 INT83526 Negative_regulation of Gene_expression of Pnmt 1 0.41 0 0.25
49 INT287126 Negative_regulation of Negative_regulation of Comt 1 0.37 0.78 0.25
50 INT300944 Regulation of DNMT3A 1 0.21 0.91 0.24
51 INT61818 Positive_regulation of Ocln 6 0.23 4.11 0.22
52 INT245799 Protein_catabolism of Ocln 2 0.62 1.78 0.22
53 INT245798 Positive_regulation of Negative_regulation of Ocln 2 0.27 1.9 0.22
54 INT300430 Negative_regulation of Phosphorylation of Ocln 1 0.19 0.43 0.21
55 INT291082 Positive_regulation of Protein_catabolism of Ocln 1 0.31 0.96 0.2
56 INT291080 Negative_regulation of Protein_catabolism of Ocln 1 0.26 0.96 0.2
57 INT130125 Regulation of Ocln 5 0.44 0.87 0.19
58 INT16756 Regulation of Transcription of Pnmt 2 0.39 0.08 0.18
59 INT159142 Regulation of Gene_expression of Ocln 3 0.25 1.36 0.16
60 INT291670 Negative_regulation of Dnmt3a 1 0.31 0.7 0.14
61 INT191163 Transcription of DNMT3B 4 0.50 0.46 0.13
62 INT217500 Phosphorylation of Ocln 1 0.24 0.96 0.13
63 INT205210 Transcription of Ocln 2 0.32 0.58 0.11
64 INT209806 Transcription of Comt 1 0.69 2.12 0.11
65 INT159144 Positive_regulation of Gene_expression of Ocln 1 0.27 1.04 0.09
66 INT66162 Positive_regulation of Binding of Pnmt 1 0.49 0 0.08
67 INT61820 Positive_regulation of Negative_regulation of Ocln 1 0.15 1.65 0.08
68 INT66164 Negative_regulation of Binding of Pnmt 1 0.41 0 0.08
69 INT66163 Binding of Pnmt 1 0.36 0 0.08
70 INT217516 Negative_regulation of Phosphorylation of Ocln 1 0.17 0.77 0.07
71 INT292609 Negative_regulation of Positive_regulation of DNMT3B 1 0.22 1.3 0.07
72 INT217502 Positive_regulation of Phosphorylation of Ocln 1 0.13 0.19 0.06
73 INT303527 Transcription of Ocln 1 0.20 0.35 0.06
74 INT183393 Gene_expression of Dnmt3a 3 0.43 1.08 0.04
75 INT265559 Regulation of Gene_expression of Ocln 2 0.13 1.01 0.04
76 INT355217 Negative_regulation of Binding of Ocln 1 0.27 0.21 0.04
77 INT291678 Regulation of Dnmt3a 1 0.28 0.48 0.04
78 INT245802 Negative_regulation of Negative_regulation of Ocln 1 0.10 0.89 0.03
79 INT217513 Positive_regulation of Positive_regulation of Ocln 1 0.15 0.66 0.03
80 INT265322 Positive_regulation of Binding of Ocln 3 0.23 0.3 0
81 INT284943 Gene_expression of DNMT3A 2 0.39 1.46 0
82 INT265325 Regulation of Ocln 2 0.18 0.07 0
83 INT265333 Localization of Ocln 2 0.34 0 0
84 INT284947 Positive_regulation of Gene_expression of DNMT3A 2 0.25 1.29 0
85 INT191158 Transcription of DNMT3A 1 0.32 0.06 0
86 INT191157 Negative_regulation of Transcription of DNMT3B 1 0.19 0.06 0
87 INT191156 Binding of DNMT3A 1 0.16 0 0
88 INT305873 Regulation of Localization of Ocln 1 0.06 0 0
89 INT191160 Localization of DNMT3A 1 0.35 0 0
90 INT185991 Regulation of Gene_expression of DNMT3B 1 0.37 0 0
91 INT191152 Negative_regulation of Transcription of DNMT3A 1 0.20 0.06 0
92 INT265336 Positive_regulation of Localization of Ocln 1 0.23 0 0
93 INT183396 Positive_regulation of Gene_expression of Dnmt3a 1 0.20 0.59 0
94 INT76171 Regulation of Regulation of Pnmt 1 0.19 0 0
95 INT183391 Positive_regulation of Gene_expression of Dnmt3b 1 0.20 0.59 0
96 INT183398 Gene_expression of Dnmt3b 1 0.27 0.59 0
97 INT338263 Regulation of Gene_expression of DNMT3A 1 0.31 0.18 0
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