GO:0046513

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Name ceramide biosynthetic process
Categary Process
Go Slim No
Go Link GO:0046513
Unique Molecular Interactions 105
Total Molecular Interactions 121
Total Single Events 1661
Pain Genes Associated 13

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for ceramide biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for ceramide biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT62382 Binding of IGHG3 and SMPD2 1 0.02 0.37 1.17
2 INT62379 Negative_regulation of Binding of IGHG3 and SMPD2 1 0.03 0.37 1.17
3 INT160653 Binding of P2rx1 and Ptgfr 1 0.28 0.66 1.14
4 INT215584 P2rx1 Regulation of Localization of Gabrg1 1 0.01 0 0.92
5 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
6 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
7 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
8 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
9 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
10 INT102350 P2rx1 Negative_regulation of Localization of Il6 1 0.32 0 0.67
11 INT151783 Regulation of Binding of Calca and P2rx1 1 0.42 0.51 0.64
12 INT151778 Binding of Calca and P2rx1 1 0.35 0.5 0.64
13 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
14 INT120870 Binding of Wnk1 and Sptlc1 1 0.14 1.24 0.56
15 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
16 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
17 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
18 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
19 INT152281 Binding of P2rx1 and Trpv1 1 0.15 0.42 0.49
20 INT151782 Phosphorylation of Creb1 Positive_regulation of Gene_expression of P2rx1 1 0.41 0.07 0.44
21 INT151781 Calca Positive_regulation of Gene_expression of P2rx1 1 0.50 0.07 0.44
22 INT8356 Binding of YY1 and Smpd1 1 0.32 0 0.43
23 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
24 INT217034 P2RX1 Regulation of Gene_expression of Ik 1 0.00 0.34 0.42
25 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
26 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
27 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
28 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
29 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
30 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
31 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
32 INT196883 Prkca Regulation of P2rx1 1 0.05 0.45 0.31
33 INT210935 Il6 Positive_regulation of Smpd1 1 0.02 0.46 0.3
34 INT258857 Binding of P2rx1 and P2ry2 1 0.22 0.81 0.29
35 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
36 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
37 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
38 INT149940 Smpd1 Positive_regulation of spc 1 0.03 0.19 0.24
39 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
40 INT173358 Gnaq Positive_regulation of SMPD1 1 0.01 0.13 0.23
41 INT302978 Nqo1 Positive_regulation of Smpd2 1 0.01 1.1 0.22
42 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
43 INT216946 P2rx7 Regulation of Il10 1 0.28 0.17 0.21
44 INT107223 APEH Negative_regulation of P2rx7 1 0.00 0.13 0.21
45 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19
46 INT264277 Binding of Car2 and P2rx1 1 0.10 0 0.16
47 INT264276 Binding of Ednrb and P2rx1 1 0.00 0.17 0.16
48 INT336665 Binding of P2rx1 and P2rx2 1 0.07 0 0.14
49 INT270827 P2rx7 Positive_regulation of Localization of Panx1 1 0.41 0.18 0.13
50 INT216945 Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1 1 0.14 0.18 0.12
51 INT74504 Binding of P2rx7 and Rp2 1 0.02 0.19 0.11
52 INT313486 GOPC Positive_regulation of P2RX1 1 0.13 0 0.1
53 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
54 INT313484 Binding of P2RX1 and SST 1 0.04 0 0.09
55 INT302979 Binding of Gnb2l1 and Smpd2 1 0.07 0.71 0.09
56 INT302977 Binding of Cav1 and Smpd2 1 0.08 0.71 0.09
57 INT217036 IRF6 Positive_regulation of Gene_expression of P2rx7 1 0.02 0 0.09
58 INT270824 Binding of P2rx7 and Panx1 1 0.34 0.15 0.09
59 INT304464 Binding of P2rx7 and P2rx6 1 0.05 0 0.09
60 INT243156 Positive_regulation of P2rx7 Positive_regulation of NOS1 1 0.00 0.08 0.08
61 INT244640 AGK Negative_regulation of KIT 1 0.00 0.69 0.08
62 INT244639 AGK Negative_regulation of PDGFRB 1 0.01 0.69 0.08
63 INT270829 P2rx7 Positive_regulation of Panx1 1 0.66 0.08 0.08
64 INT244638 AGK Negative_regulation of KDR 1 0.00 0.68 0.08
65 INT340420 Hmmr Regulation of P2rx7 1 0.01 1.12 0.08
66 INT251775 AGK Negative_regulation of INSRR 1 0.00 1.1 0.07
67 INT304456 Binding of P2rx1 and P2rx4 1 0.14 0 0.07
68 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
69 INT138442 Lamb1 Negative_regulation of Lass1 1 0.01 0 0.05
70 INT340427 Positive_regulation of P2rx7 Positive_regulation of Regulation of Pkhd1 1 0.01 1 0.05
71 INT270825 P2rx7 Positive_regulation of Slc37a4 1 0.01 0 0.04
72 INT302982 Smpd1 Positive_regulation of Gene_expression of Smpd3 1 0.30 0.64 0.04
73 INT302981 Nqo1 Positive_regulation of Positive_regulation of Smpd2 1 0.00 0.45 0.04
74 INT267093 FGFR1 Positive_regulation of Gene_expression of P2rx1 1 0.03 0.2 0.03
75 INT313485 MTOR Positive_regulation of Gene_expression of P2RX1 1 0.16 0 0.03
76 INT224024 Binding of P2RX1 and WDTC1 1 0.01 0.71 0
77 INT351029 AGK Regulation of VEGFA 1 0.00 0.82 0
78 INT339800 P2RX1 Regulation of Negative_regulation of GOPC 1 0.04 0 0
79 INT291329 Binding of NOTCH1 and CERS1 1 0.06 1.42 0
80 INT255167 Binding of SAE1 and CERS1 1 0.08 0.72 0
81 INT217031 Binding of P2rx7 and Positive_regulation of Casp1 1 0.02 0 0
82 INT224027 Binding of P2RX1 and P2RY12 1 0.10 0.71 0
83 INT217032 Binding of P2rx7 and Positive_regulation of Il1 1 0.02 0 0
84 INT333637 Smpd1 Positive_regulation of IRF3 1 0.09 0.62 0
85 INT216942 Positive_regulation of P2rx7 Positive_regulation of Casp1 1 0.14 0 0
86 INT307460 P2rx7 Positive_regulation of Phosphorylation of Gsk3a 1 0.02 0 0
87 INT351030 AGK Regulation of ARAF 1 0.00 0.82 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for ceramide biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in ceramide biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12
2 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
3 INT70776 Positive_regulation of P2rx1 62 0.62 32.55 30.75
4 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
5 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
6 INT90942 Regulation of P2rx1 31 0.61 16.61 13.69
7 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
8 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
9 INT70775 Positive_regulation of Positive_regulation of P2rx1 15 0.49 8.65 8.49
10 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
11 INT95172 Localization of P2rx1 14 0.78 6.77 7.81
12 INT90943 Negative_regulation of P2rx1 13 0.42 8.21 7.22
13 INT114014 Positive_regulation of Gene_expression of P2rx1 13 0.69 7.77 7.15
14 INT91351 Gene_expression of P2rx1 28 0.75 5.89 6.78
15 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
16 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
17 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
18 INT71758 Gene_expression of P2RX1 40 0.75 9.01 6.14
19 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
20 INT171033 Localization of SMPD1 15 0.16 11.92 5.16
21 INT171019 Gene_expression of SMPD1 26 0.27 12.08 5.08
22 INT71759 Positive_regulation of P2RX1 13 0.67 3.53 4.9
23 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
24 INT144396 Positive_regulation of P2rx1 11 0.49 3.25 4.23
25 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95
26 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
27 INT95171 Binding of P2rx1 12 0.36 4.69 3.92
28 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
29 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
30 INT26833 Negative_regulation of P2rx1 9 0.41 1.5 2.89
31 INT171013 Regulation of SMPD1 4 0.11 4.84 2.74
32 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
33 INT171032 Positive_regulation of SMPD1 9 0.12 8.94 2.52
34 INT121435 Negative_regulation of Gene_expression of P2rx1 3 0.43 1.82 2.21
35 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
36 INT215166 Binding of P2rx1 5 0.35 0.41 1.97
37 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
38 INT106984 Regulation of P2RX1 12 0.60 2.05 1.75
39 INT86914 Positive_regulation of Smpd1 11 0.43 4.73 1.74
40 INT146948 Negative_regulation of Positive_regulation of P2rx1 2 0.34 2.23 1.74
41 INT149435 Regulation of Positive_regulation of P2rx1 2 0.30 1.55 1.67
42 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
43 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
44 INT151777 Regulation of Gene_expression of P2rx1 3 0.60 1.97 1.48
45 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
46 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
47 INT20233 Negative_regulation of SMPD1 8 0.51 4.19 1.4
48 INT215162 Phosphorylation of P2rx1 2 0.43 0.12 1.34
49 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
50 INT155662 Positive_regulation of Localization of P2rx1 2 0.47 1.92 1.26
51 INT71757 Localization of P2RX1 4 0.73 2.11 1.22
52 INT132283 Regulation of P2rx1 3 0.13 0 1.2
53 INT62385 Localization of SMPD2 4 0.68 3.45 1.19
54 INT160652 Positive_regulation of Binding of P2rx1 1 0.36 0.67 1.15
55 INT107143 Negative_regulation of P2RX1 11 0.56 2.92 1.01
56 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
57 INT171038 Positive_regulation of Localization of SMPD1 2 0.08 1.8 0.99
58 INT267071 Positive_regulation of Gene_expression of P2rx1 2 0.49 1.77 0.98
59 INT113887 Positive_regulation of Negative_regulation of P2rx7 1 0.22 1.02 0.96
60 INT127103 Negative_regulation of Gene_expression of P2rx1 5 0.41 0.46 0.91
61 INT192123 Transcription of P2rx1 4 0.27 1.24 0.91
62 INT151776 Positive_regulation of Transcription of P2rx7 1 0.03 0.53 0.86
63 INT112760 Negative_regulation of Positive_regulation of Smpd1 2 0.38 1.45 0.84
64 INT148118 Positive_regulation of Gene_expression of P2RX1 4 0.48 0.78 0.83
65 INT302953 Positive_regulation of Smpd2 1 0.52 9.07 0.83
66 INT171030 Positive_regulation of Gene_expression of SMPD1 2 0.09 0.92 0.82
67 INT271589 Regulation of Transcription of P2rx7 1 0.05 0.5 0.78
68 INT171024 Negative_regulation of Localization of SMPD1 1 0.07 1.29 0.72
69 INT125734 Negative_regulation of Transcription of P2rx7 1 0.38 0.81 0.67
70 INT185485 Negative_regulation of Localization of P2rx7 1 0.26 0.95 0.62
71 INT224011 Binding of P2RX1 7 0.45 1.12 0.6
72 INT103456 Positive_regulation of SMPD2 4 0.49 1.85 0.55
73 INT217018 Regulation of Regulation of P2RX1 3 0.26 0.34 0.54
74 INT215787 Localization of P2rx1 3 0.68 0.49 0.54
75 INT171043 Negative_regulation of Gene_expression of SMPD1 2 0.08 1.15 0.53
76 INT153099 Negative_regulation of Positive_regulation of P2rx7 1 0.42 0.25 0.5
77 INT215732 Negative_regulation of Binding of P2rx7 1 0.11 0.74 0.49
78 INT313494 Regulation of Gene_expression of P2RX1 3 0.42 0 0.45
79 INT278114 Negative_regulation of Negative_regulation of P2rx7 1 0.21 0 0.45
80 INT215741 Positive_regulation of Transcription of P2rx7 1 0.15 1.15 0.43
81 INT215494 Positive_regulation of Phosphorylation of P2rx1 1 0.26 0 0.42
82 INT217012 Transcription of P2RX1 1 0.21 0.26 0.39
83 INT239115 Regulation of Binding of P2rx1 1 0.16 0 0.39
84 INT215503 Negative_regulation of Positive_regulation of P2rx1 1 0.23 0 0.38
85 INT341920 Negative_regulation of Binding of P2rx1 1 0.20 0.06 0.36
86 INT217525 Gene_expression of SMPD2 9 0.75 1.9 0.35
87 INT121239 Regulation of Positive_regulation of P2rx7 2 0.61 1.32 0.32
88 INT173329 Protein_catabolism of SMPD1 1 0.13 0 0.31
89 INT216937 Regulation of Binding of P2rx7 1 0.44 0.08 0.29
90 INT103453 Positive_regulation of Localization of SMPD2 1 0.03 0.54 0.27
91 INT103455 Negative_regulation of Positive_regulation of SMPD2 1 0.02 0.5 0.25
92 INT103454 Negative_regulation of Localization of SMPD2 1 0.02 0.5 0.25
93 INT302967 Localization of Smpd2 1 0.56 1.29 0.24
94 INT216938 Negative_regulation of Localization of P2rx7 1 0.37 0.25 0.24
95 INT84638 Regulation of Smpd1 3 0.37 2.36 0.22
96 INT138438 Gene_expression of Smpd1 7 0.67 2.67 0.21
97 INT309940 Localization of Smpd1 3 0.21 2.79 0.21
98 INT216940 Negative_regulation of Binding of P2rx7 1 0.37 0.15 0.2
99 INT216889 Phosphorylation of P2rx7 1 0.23 0 0.18
100 INT232104 Negative_regulation of Gene_expression of SMPD2 1 0.02 0.14 0.18
101 INT138436 Positive_regulation of Gene_expression of Smpd1 3 0.41 0.6 0.17
102 INT224005 Negative_regulation of Gene_expression of P2RX1 3 0.40 0.48 0.17
103 INT171035 Binding of SMPD1 1 0.06 1.57 0.17
104 INT307467 Regulation of Binding of P2rx7 1 0.08 0 0.16
105 INT147970 Positive_regulation of Positive_regulation of Smpd1 3 0.43 0.88 0.15
106 INT270813 Positive_regulation of Localization of P2rx7 1 0.46 0.24 0.15
107 INT132294 Positive_regulation of Sptlc1 3 0.31 3.84 0.14
108 INT138435 Negative_regulation of Lass1 1 0.07 0 0.14
109 INT173347 Regulation of Gene_expression of SMPD1 1 0.07 0.48 0.14
110 INT147971 Positive_regulation of Negative_regulation of Smpd1 1 0.43 0 0.11
111 INT341919 Positive_regulation of Binding of P2rx1 1 0.23 0 0.11
112 INT302942 Regulation of Smpd2 1 0.46 0.55 0.11
113 INT63795 Phosphorylation of Smpd1 1 0.00 0 0.11
114 INT20232 Negative_regulation of Negative_regulation of SMPD1 1 0.37 0.55 0.1
115 INT302949 Negative_regulation of Positive_regulation of Smpd2 1 0.32 0.75 0.09
116 INT307481 Phosphorylation of P2rx7 1 0.15 0.35 0.08
117 INT110410 Negative_regulation of CERS1 1 0.01 0.09 0.08
118 INT307480 Positive_regulation of Phosphorylation of P2rx7 1 0.09 0.35 0.08
119 INT339811 Regulation of Positive_regulation of P2RX1 1 0.42 0 0.08
120 INT302963 Protein_catabolism of Smpd1 1 0.39 0.86 0.08
121 INT161383 Binding of AGK 1 0.32 0.68 0.08
122 INT217524 Regulation of Gene_expression of SMPD2 1 0.44 0.53 0.06
123 INT217526 Positive_regulation of Gene_expression of SMPD2 1 0.49 0.53 0.06
124 INT232103 Binding of SMPD2 1 0.02 0.47 0.05
125 INT215817 Transcription of P2rx1 1 0.18 0 0.04
126 INT302955 Regulation of Positive_regulation of Smpd2 1 0.34 0.24 0.04
127 INT313493 Positive_regulation of Negative_regulation of P2RX1 1 0.48 0 0.04
128 INT189969 Phosphorylation of SMPD2 1 0.25 0.44 0.03
129 INT295510 Negative_regulation of Sptlc1 4 0.11 2.11 0
130 INT179728 Gene_expression of CERS1 2 0.15 1.04 0
131 INT232105 Negative_regulation of SMPD2 2 0.42 0.7 0
132 INT255168 Binding of CERS1 2 0.07 1.85 0
133 INT278055 Negative_regulation of AGK 2 0.01 2.1 0
134 INT284584 Localization of CERS1 1 0.01 0.32 0
135 INT320839 Regulation of Gene_expression of Smpd1 1 0.37 0.61 0
136 INT302970 Gene_expression of Smpd2 1 0.58 0.97 0
137 INT232102 Transcription of SMPD2 1 0.04 0.07 0
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