GO:0046578

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Name regulation of Ras protein signal transduction
Categary Process
Go Slim No
Go Link GO:0046578
Unique Molecular Interactions 67
Total Molecular Interactions 83
Total Single Events 475
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of Ras protein signal transduction. They are ordered first by their pain relevance and then by number of times they were reported for regulation of Ras protein signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT192080 Foxm1 Positive_regulation of Cnr1 2 0.14 0.72 1.3
2 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03
3 INT149390 Foxm1 Positive_regulation of Trpa1 1 0.28 0.31 0.94
4 INT138353 Foxm1 Positive_regulation of Phosphorylation of Trpv1 1 0.10 0.31 0.51
5 INT138352 Foxm1 Positive_regulation of Trpa1 1 0.05 0.33 0.51
6 INT206010 Foxm1 Positive_regulation of Gene_expression of Il18 1 0.03 0.72 0.5
7 INT86088 Foxm1 Positive_regulation of Binding of Crygs 1 0.04 0 0.49
8 INT86089 Foxm1 Regulation of Binding of Crygs 1 0.02 0 0.49
9 INT118919 Binding of FRTS and Sh2b2 1 0.24 0 0.39
10 INT97790 Foxm1 Negative_regulation of Gene_expression of Nos2 1 0.03 0.16 0.36
11 INT225119 Foxm1 Regulation of Localization of TGFB1 1 0.01 0.63 0.34
12 INT213798 Sh2b2 Regulation of tf 1 0.12 0.53 0.27
13 INT213799 Sh2b2 Regulation of Tfeb 1 0.26 0.54 0.27
14 INT225118 Foxm1 Positive_regulation of Gene_expression of MMP2 1 0.01 0.34 0.23
15 INT225117 Foxm1 Regulation of Gene_expression of FN1 1 0.01 0.4 0.22
16 INT213812 Sh2b2 Positive_regulation of Tfeb 1 0.44 0.45 0.2
17 INT286769 Tusc2 Regulation of Foxm1 1 0.02 1.55 0.15
18 INT175196 Binding of NCOR1 and NUP62 1 0.02 0.84 0.12
19 INT207112 Sh2b2 Positive_regulation of Phosphorylation of Akt2 1 0.68 0.24 0.12
20 INT207115 Sh2b2 Positive_regulation of Akt2 1 0.49 0.24 0.12
21 INT175195 Binding of SH2B2 and NUP62 1 0.01 0 0.07
22 INT263743 Rasgrf1 Positive_regulation of Positive_regulation of Mapk1 1 0.11 0 0.06
23 INT263770 Rasgrf1 Positive_regulation of Positive_regulation of Grin1 1 0.24 0 0.06
24 INT263727 Binding of Grin2b and Rasgrf1 1 0.18 0 0.05
25 INT263730 Binding of Grin2a and Rasgrf1 1 0.23 0 0.05
26 INT197917 Binding of ESR1 and Sh2b2 1 0.01 0 0.04
27 INT213803 Binding of Foxm1 and Tfe3 1 0.00 1.09 0.03
28 INT213810 Binding of Foxm1 and Tfeb 1 0.00 1.09 0.03
29 INT206178 Foxm1 Positive_regulation of Protein_catabolism of Olr1 1 0.00 0.47 0
30 INT232045 Binding of FOXM1 and RNPC3 1 0.00 0.31 0
31 INT232051 Binding of FOXM1 and KRAS 1 0.00 0.63 0
32 INT206180 Foxm1 Positive_regulation of Transcription of Olr1 1 0.00 0.48 0
33 INT175192 Binding of NUP62 and GOPC 1 0.03 0 0
34 INT276589 Binding of Iqgap1 and Plce1 1 0.19 0.34 0
35 INT188436 Negative_regulation of NUP62 Positive_regulation of TNFRSF11A 1 0.39 1.6 0
36 INT232044 Binding of FOXM1 and LMBRD1 1 0.00 0.32 0
37 INT276582 Binding of Espn and Plce1 1 0.01 0.34 0
38 INT249828 Foxm1 Positive_regulation of Transcription of BIRC5 1 0.56 0.12 0
39 INT175194 Binding of UBC and NUP62 1 0.01 0.05 0
40 INT175193 NUP62 Regulation of Binding of TRAF6 1 0.07 0.06 0
41 INT249822 Foxm1 Positive_regulation of Transcription of Plk1 1 0.50 0.12 0
42 INT249824 Ppp4c Positive_regulation of Foxm1 1 0.24 0 0
43 INT232046 Binding of DDR1 and FOXM1 1 0.00 0.63 0
44 INT249827 Foxm1 Positive_regulation of Transcription of Cenpb 1 0.56 0.12 0
45 INT341632 Binding of EGFR and FOXM1 1 0.02 0.56 0
46 INT175191 Binding of TRAF6 and NUP62 1 0.06 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of Ras protein signal transduction. They are ordered first by their pain relevance and then by number of times they were reported in regulation of Ras protein signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT50337 Negative_regulation of Foxm1 24 0.43 11.12 6.48
2 INT43524 Positive_regulation of Sh2b2 16 0.58 2.95 5.78
3 INT55513 Binding of Foxm1 19 0.37 2.37 5.54
4 INT83735 Gene_expression of Foxm1 41 0.77 22.9 5.07
5 INT92509 Regulation of Sh2b2 7 0.35 3.41 3.8
6 INT48292 Negative_regulation of Sh2b2 9 0.26 2.14 3.26
7 INT50335 Positive_regulation of Foxm1 20 0.69 5.11 2.81
8 INT182893 Gene_expression of Sh2b2 8 0.65 1.74 2.65
9 INT113203 Regulation of Foxm1 8 0.34 7.5 2.36
10 INT138349 Phosphorylation of Foxm1 1 0.10 0.9 1.05
11 INT72710 Negative_regulation of Negative_regulation of Foxm1 3 0.10 0.55 0.84
12 INT284739 Positive_regulation of Gene_expression of Sh2b2 2 0.26 0.83 0.71
13 INT182036 Gene_expression of Sh2b2 2 0.13 1.74 0.67
14 INT203749 Binding of FOXM1 10 0.31 6.1 0.64
15 INT3501 Localization of Sh2b2 6 0.73 0.88 0.62
16 INT249764 Regulation of Binding of Foxm1 1 0.39 0.19 0.58
17 INT206006 Negative_regulation of Gene_expression of Foxm1 4 0.43 2.63 0.56
18 INT175219 Binding of NUP62 31 0.27 4.51 0.53
19 INT86087 Negative_regulation of Binding of Foxm1 1 0.28 0 0.52
20 INT206009 Transcription of Foxm1 2 0.68 1.49 0.51
21 INT197880 Binding of Sh2b2 2 0.19 0 0.38
22 INT50336 Negative_regulation of Positive_regulation of Foxm1 1 0.30 0 0.38
23 INT249785 Positive_regulation of Gene_expression of Foxm1 13 0.69 4.71 0.36
24 INT243808 Positive_regulation of Transcription of Sh2b2 1 0.29 0.86 0.33
25 INT243807 Transcription of Sh2b2 1 0.39 0.85 0.33
26 INT313251 Negative_regulation of Positive_regulation of Sh2b2 1 0.12 0 0.29
27 INT284738 Positive_regulation of Localization of Sh2b2 1 0.09 0.6 0.26
28 INT201239 Gene_expression of FOXM1 9 0.51 4.07 0.19
29 INT203750 Positive_regulation of FOXM1 8 0.39 2.72 0.19
30 INT203751 Negative_regulation of FOXM1 2 0.20 0.94 0.11
31 INT175226 Gene_expression of NUP62 4 0.52 1.26 0.05
32 INT188456 Negative_regulation of Gene_expression of NUP62 1 0.33 0.99 0.05
33 INT249792 Regulation of Gene_expression of Foxm1 1 0.45 0.45 0.04
34 INT249769 Localization of Foxm1 6 0.74 1.13 0
35 INT268145 Negative_regulation of Sh2b2 1 0.41 0.07 0
36 INT188443 Negative_regulation of NUP62 1 0.33 1.53 0
37 INT268165 Binding of Sh2b2 1 0.36 0.13 0
38 INT207724 Transcription of FOXM1 1 0.58 0.85 0
39 INT175215 Negative_regulation of Binding of NUP62 1 0.19 0.13 0
40 INT249793 Regulation of Transcription of Foxm1 1 0.45 0 0
41 INT249780 Positive_regulation of Binding of Foxm1 1 0.50 0.5 0
42 INT249768 Regulation of Localization of Foxm1 1 0.39 0 0
43 INT188454 Positive_regulation of NUP62 1 0.36 0.92 0
44 INT117327 Negative_regulation of Negative_regulation of Sh2b2 1 0.25 0.13 0
45 INT249776 Negative_regulation of Localization of Foxm1 1 0.37 0.46 0
46 INT117326 Positive_regulation of Negative_regulation of Sh2b2 1 0.27 0.16 0
47 INT203752 Regulation of FOXM1 1 0.02 0 0
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