GO:0046580

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Name negative regulation of Ras protein signal transduction
Categary Process
Go Slim No
Go Link GO:0046580
Unique Molecular Interactions 74
Total Molecular Interactions 113
Total Single Events 712
Pain Genes Associated 18

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of Ras protein signal transduction. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of Ras protein signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
2 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
3 INT224693 Timp2 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65
4 INT124831 Fbp1 Positive_regulation of Nos2 1 0.36 0.64 0.61
5 INT342619 Mmp2 Negative_regulation of Timp2 1 0.42 1.48 0.57
6 INT342621 VEGFA Negative_regulation of Timp2 1 0.09 1.53 0.57
7 INT164973 Binding of RASA1 and Rgs7 1 0.00 0 0.54
8 INT164972 Binding of RASA1 and Rgs8 1 0.00 0 0.53
9 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
10 INT191616 Binding of Cbln1 and Nf1 1 0.01 0.2 0.32
11 INT191620 Binding of Nf1 and Gopc 1 0.08 0.2 0.32
12 INT191611 Nf1 Regulation of ras 1 0.26 0.18 0.3
13 INT229635 SPINK5 Positive_regulation of NF1 1 0.01 2.17 0.3
14 INT103197 Nf1 Negative_regulation of ras 1 0.04 1.19 0.17
15 INT191615 Binding of Nf1 and Flna 1 0.08 0.53 0.17
16 INT191621 Binding of Drd3 and Nf1 1 0.32 0.53 0.17
17 INT103198 NF1 Negative_regulation of ras 1 0.05 1.19 0.16
18 INT328793 Binding of Mmp7 and Timp2 1 0.00 0.72 0.15
19 INT328794 Binding of Timp2 and Mmp3 1 0.00 0.72 0.15
20 INT302676 Binding of OPA1 and MFN2 1 0.46 1.12 0.14
21 INT304824 Binding of Rasa1 and Tnnc1 1 0.01 0 0.13
22 INT175196 Binding of NCOR1 and NUP62 1 0.02 0.84 0.12
23 INT191612 Nf1 Positive_regulation of ras 1 0.25 2.6 0.11
24 INT217476 Nup62 Positive_regulation of Ngf 1 0.37 0.52 0.1
25 INT217477 Traf6 Positive_regulation of Binding of Nup62 1 0.32 0.47 0.09
26 INT191617 Binding of Nf1 and Rtcd1 1 0.01 0.95 0.08
27 INT137632 Rasa1 Regulation of Ednrb 1 0.05 0 0.08
28 INT238625 Mef2c Regulation of Gene_expression of Syngap1 1 0.10 0.16 0.08
29 INT175195 Binding of SH2B2 and NUP62 1 0.01 0 0.07
30 INT217472 Binding of Nup62 and Mul1 1 0.12 0 0.05
31 INT217471 Binding of Nup62 and Traf6 1 0.26 0 0.05
32 INT217468 Positive_regulation of Binding of Nup62 and Mul1 1 0.16 0 0.05
33 INT217467 Binding of Nup62 and Tnfrsf11a 1 0.31 0 0.05
34 INT247819 Cxadr Regulation of Gene_expression of Rasa1 1 0.06 1.04 0.04
35 INT191613 Binding of Nf1 and Rasa1 1 0.06 0.88 0.03
36 INT311658 Spry1 Regulation of Regulation of Slc12a3 1 0.13 0.81 0
37 INT157811 TGFB1 Positive_regulation of Timp2 1 0.02 0.06 0
38 INT311660 Binding of Gt(ROSA)26Sor and Spry1 1 0.03 0.91 0
39 INT225892 Binding of GAB1 and RASA1 1 0.01 0.06 0
40 INT217473 Nup62 Regulation of Tnfrsf11a 1 0.38 0.66 0
41 INT311661 Spry1 Regulation of Slc12a3 1 0.30 1.44 0
42 INT331235 RASA1 Positive_regulation of Mtor 1 0.00 0.32 0
43 INT194333 Binding of MFN2 and Racgap1 1 0.01 0.38 0
44 INT232893 Binding of ABR and Nup62 1 0.03 0.13 0
45 INT311656 Binding of Wnt1 and Spry1 1 0.30 0.39 0
46 INT271966 Phosphorylation of Rasa1 Positive_regulation of Tsc2 1 0.01 0.31 0
47 INT175192 Binding of NUP62 and GOPC 1 0.03 0 0
48 INT199577 Tnk1 Negative_regulation of Akt1 1 0.00 0.79 0
49 INT199579 Tnk1 Negative_regulation of Raf1 1 0.01 0.78 0
50 INT188436 Negative_regulation of NUP62 Positive_regulation of TNFRSF11A 1 0.39 1.6 0
51 INT268597 Mir10a Regulation of TNK1 1 0.27 0.55 0
52 INT175194 Binding of UBC and NUP62 1 0.01 0.05 0
53 INT293795 Binding of RASA1 and ras 1 0.00 0.08 0
54 INT199578 Tnk1 Negative_regulation of Braf 1 0.01 0.78 0
55 INT175193 NUP62 Regulation of Binding of TRAF6 1 0.07 0.06 0
56 INT331229 Rasa1 Positive_regulation of Mtor 1 0.00 0.32 0
57 INT331233 Binding of Mtor and Rasa1 1 0.00 0.32 0
58 INT331236 Binding of RASA1 and Mtor 1 0.00 0.32 0
59 INT180836 Binding of CTD and NF1 1 0.15 0.2 0
60 INT311657 Binding of Cbl and Spry2 1 0.10 0.18 0
61 INT175191 Binding of TRAF6 and NUP62 1 0.06 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of Ras protein signal transduction. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of Ras protein signal transduction. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT157802 Negative_regulation of Timp2 7 0.54 5.75 5.51
2 INT68216 Binding of NF1 40 0.48 51.24 4.59
3 INT55743 Gene_expression of Timp2 25 0.31 8.95 4.3
4 INT228465 Positive_regulation of Timp2 4 0.64 6.29 3.54
5 INT179338 Gene_expression of Timp2 7 0.55 5.75 3.13
6 INT17993 Negative_regulation of RASA1 8 0.41 7.34 2.62
7 INT61434 Regulation of Nf1 3 0.26 1.39 2.4
8 INT64700 Binding of Nf1 14 0.45 15.24 2.29
9 INT120109 Negative_regulation of Timp2 8 0.33 3.28 2.23
10 INT43900 Gene_expression of RASA1 13 0.58 12 2.03
11 INT84510 Positive_regulation of Nf1 8 0.69 9.52 1.93
12 INT68181 Binding of Nf1 6 0.48 8.14 1.88
13 INT37649 Gene_expression of Fbp1 4 0.49 3.16 1.84
14 INT230668 Gene_expression of Rasa1 9 0.68 3.25 1.74
15 INT212391 Gene_expression of Tnk1 1 0.07 1.61 1.71
16 INT215928 Binding of Timp2 1 0.23 0.79 1.66
17 INT14916 Binding of RASA1 15 0.37 13.64 1.44
18 INT131645 Negative_regulation of Nf1 10 0.58 8.12 1.24
19 INT61993 Gene_expression of NF1 29 0.78 34.47 1.23
20 INT123839 Positive_regulation of Timp2 6 0.15 4.69 1.21
21 INT211723 Binding of Rasa1 3 0.07 0.85 1.03
22 INT37648 Protein_catabolism of Fbp1 2 0.54 1.5 0.97
23 INT77054 Regulation of Gene_expression of Timp2 2 0.05 0.7 0.96
24 INT14402 Positive_regulation of Fbp1 4 0.38 2.11 0.93
25 INT311638 Gene_expression of Spry1 1 0.72 16.38 0.86
26 INT55742 Positive_regulation of Gene_expression of Timp2 2 0.08 1.81 0.82
27 INT342616 Regulation of Timp2 1 0.56 1.75 0.81
28 INT37650 Negative_regulation of Fbp1 1 0.55 1.24 0.77
29 INT304823 Negative_regulation of Rasa1 6 0.10 0.39 0.76
30 INT127432 Gene_expression of Nup62 20 0.71 11.01 0.71
31 INT68179 Gene_expression of Nf1 9 0.78 8.87 0.68
32 INT324890 Negative_regulation of Negative_regulation of Timp2 2 0.40 1.09 0.68
33 INT179133 Localization of Nf1 2 0.80 2.18 0.68
34 INT49650 Gene_expression of Nf1 4 0.76 3.38 0.67
35 INT342612 Positive_regulation of Positive_regulation of Timp2 1 0.43 1.05 0.57
36 INT127878 Negative_regulation of Positive_regulation of Timp2 1 0.07 1.12 0.57
37 INT90416 Positive_regulation of RASA1 3 0.67 1.58 0.56
38 INT175219 Binding of NUP62 31 0.27 4.51 0.53
39 INT61992 Positive_regulation of Gene_expression of NF1 3 0.50 4.47 0.51
40 INT139666 Binding of Timp2 3 0.13 0.55 0.5
41 INT7248 Localization of RASA1 4 0.61 2.52 0.47
42 INT316933 Transcription of Nf1 1 0.18 0.49 0.47
43 INT316939 Positive_regulation of Transcription of Nf1 1 0.16 0.49 0.47
44 INT55893 Gene_expression of Rasa1 5 0.52 1.04 0.44
45 INT247798 Negative_regulation of Rasa1 3 0.09 1.05 0.44
46 INT217452 Binding of Nup62 1 0.38 2.7 0.44
47 INT139667 Transcription of Timp2 2 0.17 0.45 0.43
48 INT98460 Positive_regulation of Tnk1 2 0.29 0.49 0.43
49 INT230653 Phosphorylation of Rasa1 3 0.55 0.6 0.42
50 INT167616 Protein_catabolism of Ppp2cb 1 0.02 0.87 0.42
51 INT129343 Positive_regulation of Rasa1 2 0.10 1.03 0.37
52 INT156121 Phosphorylation of Tnk1 2 0.03 0.3 0.37
53 INT269822 Transcription of Timp2 1 0.36 1.43 0.36
54 INT303286 Localization of Nup62 1 0.08 0 0.35
55 INT112334 Regulation of NF1 18 0.52 15.85 0.34
56 INT76999 Regulation of Fbp1 1 0.17 0.58 0.34
57 INT204941 Protein_catabolism of Timp2 1 0.03 0.35 0.32
58 INT317974 Localization of Timp2 1 0.38 0.88 0.3
59 INT55894 Positive_regulation of Gene_expression of Rasa1 1 0.47 0.19 0.28
60 INT217446 Negative_regulation of Binding of Nup62 1 0.33 1.54 0.25
61 INT129342 Positive_regulation of Positive_regulation of Nf1 1 0.50 0.79 0.23
62 INT14401 Binding of Fbp1 2 0.31 2.24 0.22
63 INT68180 Regulation of Nf1 2 0.27 2.02 0.22
64 INT177938 Negative_regulation of NF1 9 0.43 10.3 0.2
65 INT129341 Negative_regulation of Gene_expression of Nf1 2 0.43 1.67 0.2
66 INT324889 Positive_regulation of Gene_expression of Timp2 1 0.17 0.55 0.2
67 INT98459 Positive_regulation of Positive_regulation of Tnk1 1 0.06 0.14 0.2
68 INT217463 Positive_regulation of Nup62 5 0.39 1.79 0.17
69 INT155285 Positive_regulation of Nf1 1 0.16 0.55 0.17
70 INT201013 Regulation of Gene_expression of RASA1 1 0.05 0.16 0.16
71 INT103196 Negative_regulation of Gene_expression of Nf1 1 0.57 1.21 0.16
72 INT232830 Positive_regulation of Protein_catabolism of Nup62 3 0.39 0.75 0.15
73 INT194332 Localization of MFN2 2 0.74 1.45 0.15
74 INT55892 Negative_regulation of Gene_expression of Rasa1 1 0.29 0.1 0.15
75 INT304822 Regulation of Negative_regulation of Rasa1 1 0.05 0 0.14
76 INT311644 Positive_regulation of Gene_expression of Spry1 1 0.46 2.54 0.13
77 INT304820 Transcription of Rasa1 1 0.10 0 0.12
78 INT201009 Transcription of RASA1 1 0.07 0.14 0.12
79 INT217454 Positive_regulation of Gene_expression of Nup62 2 0.39 1.56 0.11
80 INT349974 Positive_regulation of Rasa1 1 0.04 0.92 0.11
81 INT153941 Localization of Timp2 2 0.58 0.07 0.1
82 INT180707 Regulation of Localization of Timp2 1 0.35 0 0.1
83 INT127433 Negative_regulation of Gene_expression of Nup62 2 0.53 2.36 0.08
84 INT61991 Negative_regulation of Gene_expression of NF1 1 0.59 1.67 0.08
85 INT238567 Gene_expression of Syngap1 1 0.47 0.15 0.08
86 INT232834 Protein_catabolism of Nup62 3 0.56 0.8 0.07
87 INT190026 Positive_regulation of Gene_expression of Nf1 3 0.53 2.45 0.07
88 INT91099 Gene_expression of MFN2 2 0.67 1.32 0.07
89 INT217461 Negative_regulation of Positive_regulation of Nup62 1 0.33 0.41 0.07
90 INT175226 Gene_expression of NUP62 4 0.52 1.26 0.05
91 INT180695 Regulation of Timp2 2 0.21 0.67 0.05
92 INT217443 Regulation of Nup62 1 0.48 1.47 0.05
93 INT311643 Negative_regulation of Spry1 1 0.40 0.95 0.05
94 INT188456 Negative_regulation of Gene_expression of NUP62 1 0.33 0.99 0.05
95 INT204532 Gene_expression of TNK1 1 0.01 0.15 0.04
96 INT247808 Negative_regulation of Localization of Rasa1 1 0.06 0.96 0.04
97 INT311641 Regulation of Gene_expression of Spry1 1 0.57 0.5 0.04
98 INT247815 Localization of Rasa1 1 0.10 1.69 0.04
99 INT311647 Negative_regulation of Gene_expression of Spry1 1 0.39 0.18 0.04
100 INT194329 Positive_regulation of MFN2 1 0.40 0.74 0.03
101 INT169558 Positive_regulation of NF1 13 0.59 13.58 0
102 INT112333 Localization of NF1 2 0.51 0.63 0
103 INT216268 Positive_regulation of Positive_regulation of NF1 2 0.40 2.08 0
104 INT217457 Negative_regulation of Nup62 2 0.33 0.94 0
105 INT225851 Phosphorylation of RASA1 2 0.05 0.14 0
106 INT299138 Regulation of Positive_regulation of Timp2 1 0.12 0.26 0
107 INT199554 Negative_regulation of Tnk1 1 0.01 0.54 0
108 INT188443 Negative_regulation of NUP62 1 0.33 1.53 0
109 INT311653 Binding of Spry1 1 0.34 0.98 0
110 INT230655 Regulation of Gene_expression of Rasa1 1 0.54 0.26 0
111 INT247790 Regulation of Rasa1 1 0.05 1.44 0
112 INT311645 Gene_expression of Spry2 1 0.70 1.81 0
113 INT311639 Positive_regulation of Spry1 1 0.64 0.19 0
114 INT175215 Negative_regulation of Binding of NUP62 1 0.19 0.13 0
115 INT311640 Regulation of Binding of Spry1 1 0.42 0.77 0
116 INT287854 Negative_regulation of Ppp2cb 1 0.04 0 0
117 INT230656 Positive_regulation of Gene_expression of Rasa1 1 0.61 0.24 0
118 INT260764 Negative_regulation of Spry2 1 0.28 0.1 0
119 INT291974 Regulation of RASA1 1 0.03 0.29 0
120 INT346853 Binding of Rasa1 1 0.09 1.24 0
121 INT311634 Positive_regulation of Spry2 1 0.45 0.4 0
122 INT188454 Positive_regulation of NUP62 1 0.36 0.92 0
123 INT311633 Localization of Spry2 1 0.68 0.26 0
124 INT311628 Negative_regulation of Gene_expression of Spry2 1 0.39 0.43 0
125 INT286141 Negative_regulation of Negative_regulation of NF1 1 0.01 0.66 0
126 INT194330 Regulation of Gene_expression of MFN2 1 0.45 0.3 0
127 INT237279 Regulation of Binding of NF1 1 0.38 0.79 0
128 INT217459 Regulation of Gene_expression of Nup62 1 0.35 0.35 0
129 INT212405 Regulation of Tnk1 1 0.07 0.85 0
130 INT311654 Regulation of Spry2 1 0.21 0.75 0
131 INT177934 Regulation of Gene_expression of NF1 1 0.19 1.23 0
132 INT335031 Positive_regulation of Gene_expression of RASA1 1 0.09 1.49 0
133 INT212390 Binding of Tnk1 1 0.04 0.36 0
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