GO:0046625

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Name sphingolipid binding
Categary Function
Go Slim No
Go Link GO:0046625
Unique Molecular Interactions 53
Total Molecular Interactions 60
Total Single Events 307
Pain Genes Associated 9

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for sphingolipid binding. They are ordered first by their pain relevance and then by number of times they were reported for sphingolipid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT142990 Serpinc1 Positive_regulation of Phosphorylation of S1pr1 1 0.03 0.05 0.59
2 INT95404 Map3k1 Positive_regulation of Phosphorylation of Ephb1 1 0.12 0.16 0.46
3 INT95408 Map3k1 Positive_regulation of Ephb1 1 0.12 0.16 0.46
4 INT226341 S1PR1 Regulation of MBTPS1 1 0.00 0.76 0.44
5 INT354704 Binding of MAP3K1 and Pick1 1 0.00 0.76 0.41
6 INT226381 S1PR1 Positive_regulation of Gene_expression of IK 1 0.00 0.64 0.38
7 INT356366 S1pr1 Regulation of Gopc 1 0.19 1.22 0.33
8 INT135891 S1pr1 Regulation of Prps1 1 0.01 0.15 0.33
9 INT302842 Binding of S1PR1 and S1pr1 1 0.24 0.92 0.32
10 INT255934 Tauph Positive_regulation of Map3k1 1 0.00 0.1 0.32
11 INT255946 MAPK14 Positive_regulation of Map3k1 1 0.04 0.1 0.32
12 INT274932 Binding of Insrr and Map3k1 1 0.00 0 0.28
13 INT274947 Binding of Map3k1 and Grip1 1 0.00 0 0.27
14 INT302819 Regulation of S1pr1 Positive_regulation of Ptger2 1 0.02 0.35 0.22
15 INT302835 S1pr1 Positive_regulation of Ptger2 1 0.03 0.3 0.2
16 INT345172 Lpar1 Positive_regulation of S1pr1 1 0.21 0.19 0.19
17 INT302846 Negative_regulation of Binding of S1PR1 and S1pr1 1 0.28 0.41 0.18
18 INT302844 Positive_regulation of Binding of S1PR1 and S1pr1 1 0.32 0.52 0.15
19 INT177916 PRKG1 Positive_regulation of Positive_regulation of MAP3K1 1 0.05 1.07 0.14
20 INT280488 Bdnf Positive_regulation of Gene_expression of Map3k1 1 0.01 1.49 0.11
21 INT92389 ALK Positive_regulation of Gene_expression of Map3k1 1 0.01 1.14 0.09
22 INT232559 Map3k1 Positive_regulation of Esr1 1 0.19 0.26 0.09
23 INT251569 Binding of Ripk1 and Traf2 1 0.12 0.67 0.08
24 INT233519 Binding of S1pr1 and S1pr2 1 0.13 0.2 0.08
25 INT345178 S1pr1 Positive_regulation of Lpar1 1 0.14 0.09 0.07
26 INT345160 S1pr1 Positive_regulation of P2ry10 1 0.11 0.09 0.07
27 INT190095 Negative_regulation of Binding of Hivep3 and Traf2 1 0.15 0.08 0.04
28 INT190096 Binding of Hivep3 and Traf2 1 0.17 0.08 0.04
29 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 0.01 1.1 0.04
30 INT345147 Binding of S1pr1 and Gpbar1 1 0.03 0.07 0.03
31 INT348526 Binding of TRAF2 and EDAR 1 0.15 0.52 0.03
32 INT348538 Binding of TRAF2 and EDARADD 1 0.06 0.53 0.03
33 INT345167 Binding of S1pr1 and Lpar1 1 0.13 0.07 0.03
34 INT292553 Binding of TRAF2 and TRADD 1 0.09 0.1 0
35 INT258203 S1PR1 Positive_regulation of GTPBP4 1 0.00 0.29 0
36 INT292560 Binding of TNFRSF1A and TRAF2 1 0.08 0.09 0
37 INT215413 ITC1 Negative_regulation of MAP3K1 1 0.04 0.23 0
38 INT258207 S1PR1 Positive_regulation of Phosphorylation of IFI44 1 0.13 0 0
39 INT348521 TRAF2 Positive_regulation of MAP3K1 1 0.03 0.46 0
40 INT348689 Fgf2 Regulation of Map3k1 1 0.09 0 0
41 INT348528 TRAF2 Positive_regulation of Positive_regulation of CASP8 1 0.02 0.44 0
42 INT258206 S1PR1 Positive_regulation of Phosphorylation of MAPK1 1 0.12 0 0
43 INT213015 Binding of S1pr1 and S1pr3 1 0.16 1.17 0
44 INT215416 MAP3K1 Regulation of MAPK9 1 0.14 0.64 0
45 INT222870 Traf2 Positive_regulation of Chuk 1 0.03 0.37 0
46 INT215412 Binding of MAP3K1 and ITC1 1 0.03 0 0
47 INT215415 MAP3K1 Regulation of MAPK8 1 0.62 0.64 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for sphingolipid binding. They are ordered first by their pain relevance and then by number of times they were reported in sphingolipid binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT116163 Gene_expression of S1pr1 29 0.78 14.11 7.27
2 INT142984 Positive_regulation of S1pr1 13 0.70 7.9 3.84
3 INT159121 Positive_regulation of Map3k1 10 0.45 8.79 2.6
4 INT116164 Positive_regulation of Gene_expression of S1pr1 5 0.66 4.72 2.42
5 INT144580 Regulation of S1pr1 1 0.44 0.32 2.1
6 INT95400 Negative_regulation of Map3k1 3 0.15 0.78 1.92
7 INT144581 Gene_expression of S1pr1 4 0.77 1.64 1.77
8 INT71788 Gene_expression of MAP3K1 13 0.70 4.9 1.66
9 INT167952 Regulation of S1pr1 5 0.26 2.96 1.4
10 INT50785 Gene_expression of Map3k1 6 0.44 4.22 1.32
11 INT190067 Binding of Traf2 5 0.20 3.28 1.27
12 INT226466 Gene_expression of S1PR1 2 0.56 4.51 1.14
13 INT142989 Negative_regulation of S1pr1 2 0.43 0.72 0.99
14 INT177387 Positive_regulation of TRAF2 3 0.26 1.44 0.84
15 INT71784 Positive_regulation of Gene_expression of MAP3K1 4 0.34 4.8 0.82
16 INT50784 Positive_regulation of Gene_expression of Map3k1 2 0.06 0.94 0.8
17 INT343139 Transcription of S1pr1 1 0.67 0.74 0.77
18 INT177933 Positive_regulation of MAP3K1 6 0.42 4.13 0.76
19 INT258247 Positive_regulation of S1PR1 1 0.50 0.65 0.73
20 INT233464 Binding of S1pr1 2 0.28 1.81 0.66
21 INT142986 Phosphorylation of S1pr1 2 0.43 1.62 0.64
22 INT112665 Gene_expression of TRAF2 3 0.29 3.97 0.61
23 INT154745 Protein_catabolism of Traf2 1 0.86 1.04 0.59
24 INT154750 Positive_regulation of Protein_catabolism of Traf2 1 0.60 1.05 0.59
25 INT116165 Localization of S1pr1 4 0.80 2.2 0.58
26 INT111602 Negative_regulation of Gene_expression of MAP3K1 1 0.06 0.58 0.58
27 INT294555 Negative_regulation of Traf2 1 0.06 1.24 0.58
28 INT142982 Negative_regulation of Gene_expression of S1pr1 1 0.23 0 0.56
29 INT213000 Binding of S1PR1 9 0.47 2.33 0.54
30 INT135887 Localization of S1pr1 1 0.80 0.52 0.52
31 INT190074 Positive_regulation of Traf2 1 0.19 0.37 0.52
32 INT95401 Phosphorylation of Map3k1 1 0.21 0.16 0.46
33 INT167953 Positive_regulation of Regulation of S1pr1 1 0.42 0.83 0.46
34 INT142987 Negative_regulation of Positive_regulation of S1pr1 1 0.31 0.19 0.39
35 INT102721 Negative_regulation of MAP3K1 2 0.53 8.03 0.3
36 INT177941 Phosphorylation of MAP3K1 2 0.20 1.31 0.24
37 INT258243 Regulation of Gene_expression of S1PR1 1 0.32 0 0.21
38 INT258232 Positive_regulation of Gene_expression of S1PR1 1 0.50 0.61 0.21
39 INT98785 Negative_regulation of Gene_expression of Map3k1 1 0.03 0.69 0.21
40 INT252702 Binding of TRAF2 3 0.23 2.21 0.16
41 INT154200 Binding of Map3k1 1 0.06 0.32 0.16
42 INT154744 Regulation of Protein_catabolism of Traf2 1 0.39 0.18 0.16
43 INT302794 Negative_regulation of Binding of S1pr1 1 0.25 0.34 0.15
44 INT302812 Positive_regulation of Binding of S1PR1 1 0.45 0.52 0.15
45 INT258223 Negative_regulation of Binding of S1PR1 1 0.31 0 0.13
46 INT251559 Binding of Traf2 1 0.23 1.68 0.13
47 INT302783 Positive_regulation of Localization of S1pr1 1 0.29 0.42 0.1
48 INT302805 Regulation of Localization of S1pr1 1 0.26 0.42 0.1
49 INT173169 Regulation of MAP3K1 2 0.41 1.81 0.09
50 INT92387 Gene_expression of Map3k1 1 0.02 1.13 0.09
51 INT251560 Positive_regulation of Traf2 1 0.13 0.47 0.09
52 INT302795 Regulation of Binding of S1pr1 1 0.26 0.36 0.07
53 INT250022 Regulation of Map3k1 2 0.18 1.02 0.04
54 INT258231 Phosphorylation of S1PR1 2 0.45 0.95 0
55 INT202475 Positive_regulation of Positive_regulation of Map3k1 2 0.33 1.54 0
56 INT215426 Negative_regulation of Negative_regulation of MAP3K1 1 0.39 0.32 0
57 INT294168 Regulation of Gene_expression of S1pr1 1 0.00 0.2 0
58 INT189990 Negative_regulation of Map3k1 1 0.01 1.48 0
59 INT222849 Gene_expression of Traf2 1 0.12 0.38 0
60 INT333617 Transcription of MAP3K1 1 0.23 0.09 0
61 INT215425 Positive_regulation of Negative_regulation of MAP3K1 1 0.45 0.78 0
62 INT258241 Transcription of S1PR1 1 0.38 0.13 0
63 INT270350 Positive_regulation of S1pr1 1 0.32 0.98 0
64 INT252712 Phosphorylation of TRAF2 1 0.28 1.38 0
65 INT215419 Regulation of Localization of MAP3K1 1 0.41 0.22 0
66 INT348474 Regulation of Gene_expression of TRAF2 1 0.23 0.41 0
67 INT258245 Regulation of S1PR1 1 0.44 0.55 0
68 INT215423 Localization of MAP3K1 1 0.68 0.22 0
69 INT333621 Positive_regulation of Transcription of MAP3K1 1 0.16 0.09 0
70 INT215428 Binding of MAP3K1 1 0.44 0.05 0
71 INT258240 Localization of S1PR1 1 0.21 0 0
72 INT258229 Negative_regulation of S1PR1 1 0.31 0 0
73 INT202470 Negative_regulation of Positive_regulation of Map3k1 1 0.38 0.62 0
74 INT258233 Positive_regulation of Transcription of S1PR1 1 0.33 0.07 0
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