GO:0046626

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Name regulation of insulin receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0046626
Unique Molecular Interactions 68
Total Molecular Interactions 104
Total Single Events 494
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for regulation of insulin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for regulation of insulin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT253137 Ptpn1 Negative_regulation of Ins1 1 0.19 4.11 0.63
2 INT253147 Positive_regulation of Nr1h2 Negative_regulation of Positive_regulation of Ptpn1 1 0.17 0.61 0.33
3 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
4 INT253127 Il6 Regulation of Gene_expression of Ptpn1 1 0.24 1.31 0.17
5 INT253154 TNF Positive_regulation of Ptpn1 1 0.73 0.91 0.15
6 INT272006 Binding of YWHAQ and Tsc2 1 0.27 0.39 0.1
7 INT272003 Binding of Tsc2 and Tsc1 1 0.18 1.1 0.07
8 INT236147 Binding of Ins1 and Ptpn1 2 0.03 1.29 0.05
9 INT246793 Binding of Tsc2 and Tsc1 1 0.04 0.71 0.04
10 INT246786 Ogg1 Regulation of Phosphorylation of Tsc2 1 0.20 0.42 0.04
11 INT253132 Il6 Positive_regulation of Gene_expression of Ptpn1 1 0.42 0.54 0.03
12 INT246791 Tsc2 Regulation of Ogg1 1 0.27 0.56 0.03
13 INT246784 Negative_regulation of Tsc2 Positive_regulation of Negative_regulation of Ogg1 1 0.20 0.43 0
14 INT246811 Ros1 Positive_regulation of Tsc2 1 0.02 0 0
15 INT158907 Ogt Negative_regulation of Gene_expression of Ada 1 0.44 0 0
16 INT246808 Tsc2 Regulation of Regulation of Tsc1 1 0.02 0.05 0
17 INT246794 Ros1 Positive_regulation of Phosphorylation of Tsc2 1 0.03 0.66 0
18 INT271990 Tsc1 Positive_regulation of Tsc2 1 0.36 0.31 0
19 INT272018 Binding of TSC1 and Tsc2 1 0.17 0.48 0
20 INT246787 Akt2 Positive_regulation of Phosphorylation of Tsc2 1 0.10 0.16 0
21 INT246789 Pik3c3 Regulation of Tsc2 1 0.02 0.34 0
22 INT271991 Tsc1 Regulation of Tsc2 1 0.23 0.15 0
23 INT246809 Negative_regulation of Tsc2 Positive_regulation of Positive_regulation of Ogg1 1 0.20 0.45 0
24 INT246801 Negative_regulation of Akt1 Negative_regulation of Phosphorylation of Tsc2 1 0.17 0 0
25 INT246792 Akt1 Positive_regulation of Phosphorylation of Tsc2 1 0.19 0.78 0
26 INT272013 Binding of OGG1 and Tsc2 1 0.09 0.67 0
27 INT272010 Tsc2 Negative_regulation of OGG1 1 0.17 0.6 0
28 INT271966 Phosphorylation of Rasa1 Positive_regulation of Tsc2 1 0.01 0.31 0
29 INT246798 Akt1 Regulation of Tsc2 1 0.16 0.34 0
30 INT331224 Binding of Akt1 and Tsc2 1 0.03 0.33 0
31 INT253144 Il6 Positive_regulation of Ptpn1 1 0.62 0.42 0
32 INT246797 Tgfb1i1 Positive_regulation of Phosphorylation of Tsc2 1 0.01 0.66 0
33 INT271984 Binding of Tsc2 and Skp2 1 0.06 0.34 0
34 INT272011 Binding of RAB5A and Tsc2 1 0.02 0.16 0
35 INT272004 Binding of Hspa1b and Tsc2 1 0.01 0.45 0
36 INT271983 Binding of Tsc2 and Rap1a 1 0.02 0.16 0
37 INT246806 Gene_expression of Akt1 Positive_regulation of Phosphorylation of Tsc2 1 0.19 0.32 0
38 INT286569 Binding of Pkd1 and Tsc2 1 0.06 1.01 0
39 INT246803 Binding of Akt1 and Tsc2 1 0.14 0.85 0
40 INT271989 Binding of Tsc2 and Psmd9 1 0.02 0.47 0
41 INT300631 Binding of TSC1 and TSC2 1 0.15 2.59 0
42 INT246790 Gene_expression of Ros1 Positive_regulation of Phosphorylation of Tsc2 1 0.02 0 0
43 INT272007 Binding of Tsc2 and SCPEP1 1 0.27 0.46 0
44 INT271987 Tsc2 Regulation of Skp2 1 0.10 0.28 0
45 INT246800 Binding of Tsc2 and Ogg1 1 0.16 0.38 0
46 INT158906 Ogt Negative_regulation of Ada 1 0.33 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for regulation of insulin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in regulation of insulin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT207100 Gene_expression of Ptpn1 13 0.73 8.13 1.68
2 INT236138 Negative_regulation of Ptpn1 10 0.55 5.83 1.04
3 INT253114 Positive_regulation of Ptpn1 9 0.44 5.48 0.96
4 INT253103 Negative_regulation of Gene_expression of Ptpn1 1 0.55 2.56 0.79
5 INT252054 Phosphorylation of TSC2 4 0.80 0.63 0.67
6 INT253098 Positive_regulation of Gene_expression of Ptpn1 3 0.65 2.05 0.48
7 INT207088 Localization of Ptpn1 2 0.35 1.48 0.36
8 INT221833 Positive_regulation of TSC2 2 0.23 0.39 0.33
9 INT97779 Negative_regulation of TSC2 3 0.41 3.45 0.26
10 INT246762 Phosphorylation of Tsc2 60 0.67 15.71 0.25
11 INT154360 Localization of Tsc2 1 0.56 0.16 0.22
12 INT271943 Phosphorylation of Tsc2 9 0.52 3.35 0.13
13 INT119228 Gene_expression of TSC2 3 0.75 4.43 0.13
14 INT246776 Negative_regulation of Tsc2 18 0.48 6.82 0.12
15 INT246749 Negative_regulation of Phosphorylation of Tsc2 11 0.35 3.4 0.12
16 INT271941 Binding of Tsc2 12 0.24 2.96 0.11
17 INT253100 Positive_regulation of Positive_regulation of Ptpn1 1 0.44 0.81 0.11
18 INT246772 Regulation of Phosphorylation of Tsc2 1 0.26 1.37 0.09
19 INT246770 Positive_regulation of Negative_regulation of Tsc2 1 0.20 1.91 0.05
20 INT271916 Positive_regulation of Phosphorylation of Tsc2 4 0.32 0.52 0.04
21 INT242338 Binding of TSC2 2 0.22 1.56 0.04
22 INT236144 Regulation of Gene_expression of Ptpn1 1 0.21 0.84 0.04
23 INT271937 Positive_regulation of Binding of Tsc2 1 0.25 0 0.04
24 INT119227 Gene_expression of Tsc2 8 0.68 10.67 0.03
25 INT246774 Positive_regulation of Tsc2 6 0.41 2.4 0
26 INT271919 Gene_expression of Tsc2 6 0.39 2.23 0
27 INT228895 Binding of Tsc2 5 0.30 2.41 0
28 INT246755 Regulation of Tsc2 4 0.50 1.01 0
29 INT216011 Regulation of TSC2 2 0.26 3.31 0
30 INT271921 Negative_regulation of Tsc2 2 0.26 1.19 0
31 INT271944 Negative_regulation of Phosphorylation of Tsc2 2 0.30 0.42 0
32 INT246761 Positive_regulation of Gene_expression of Tsc2 2 0.41 1.17 0
33 INT246777 Regulation of Gene_expression of Tsc2 1 0.19 0 0
34 INT246754 Negative_regulation of Binding of Tsc2 1 0.18 0.12 0
35 INT271905 Positive_regulation of Protein_catabolism of Tsc2 1 0.35 1.46 0
36 INT246747 Negative_regulation of Negative_regulation of Tsc2 1 0.18 0.56 0
37 INT271904 Localization of Tsc2 1 0.41 1.31 0
38 INT246780 Protein_catabolism of Tsc2 1 0.28 0.15 0
39 INT286549 Regulation of Tsc2 1 0.11 0.42 0
40 INT246752 Negative_regulation of Gene_expression of Tsc2 1 0.25 0.52 0
41 INT271940 Protein_catabolism of Tsc2 1 0.50 0.7 0
42 INT246759 Positive_regulation of Phosphorylation of Tsc2 1 0.29 9.31 0
43 INT276884 Regulation of Phosphorylation of TSC2 1 0.25 0.21 0
44 INT246751 Positive_regulation of Binding of Tsc2 1 0.21 0.15 0
45 INT336102 Phosphorylation of Ptpn1 1 0.59 0.34 0
46 INT158905 Negative_regulation of Ogt 1 0.36 0 0
47 INT271909 Positive_regulation of Tsc2 1 0.25 0.06 0
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