GO:0046627

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Name negative regulation of insulin receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0046627
Unique Molecular Interactions 906
Total Molecular Interactions 1257
Total Single Events 8125
Pain Genes Associated 39

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of insulin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of insulin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT95068 Tlr4 Positive_regulation of IL1B 1 0.03 4.54 5.6
2 INT128296 Negative_regulation of IL1B Positive_regulation of Insr 1 0.10 1.36 4.52
3 INT128295 IL1B Positive_regulation of Insr 1 0.11 1.36 4.5
4 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
5 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
6 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
7 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
8 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
9 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85
10 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
11 INT140024 Tnf Positive_regulation of Gene_expression of Il1b 2 0.49 2.75 2.61
12 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
13 INT94491 Il1b Positive_regulation of Gene_expression of Tnf 1 0.25 3.81 2.19
14 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
15 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
16 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
17 INT140030 Il1b Positive_regulation of Gene_expression of Ifng 2 0.48 2.23 2
18 INT140026 Il1b Positive_regulation of Gene_expression of Tnf 2 0.49 2.23 2
19 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
20 INT81920 Binding of IL1B and NFKB1 1 0.04 1.54 1.85
21 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84
22 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
23 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
24 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
25 INT100274 IL1RN Negative_regulation of IL1B 5 0.53 1.79 1.65
26 INT83093 IL1B Positive_regulation of BDKRB1 1 0.51 0.44 1.65
27 INT61134 IL10 Negative_regulation of Gene_expression of IL1B 3 0.46 2.13 1.63
28 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55
29 INT91456 IL1B Positive_regulation of Gene_expression of CPOX 6 0.17 3.36 1.53
30 INT256360 Car2 Positive_regulation of Localization of Rela 1 0.14 0 1.51
31 INT10276 Il1b Regulation of Gene_expression of Penk 1 0.61 0.85 1.5
32 INT140028 Ifng Positive_regulation of Gene_expression of Il1b 1 0.48 1.69 1.5
33 INT136844 Binding of Prkca and Nrgn 1 0.33 0 1.47
34 INT150887 Il1b Regulation of Il10 1 0.04 1.74 1.47
35 INT158776 Il1b Regulation of Ephb1 1 0.15 0.09 1.46
36 INT221242 Ros1 Positive_regulation of Prkca 1 0.02 0.39 1.44
37 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4
38 INT161511 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1b 1 0.41 0.27 1.36
39 INT95093 ITIH4 Positive_regulation of IL1B 1 0.43 1.04 1.32
40 INT95094 Negative_regulation of ITIH4 Positive_regulation of IL1B 1 0.36 1.04 1.32
41 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3
42 INT108386 IL1B Positive_regulation of MMP1 3 0.27 1.56 1.28
43 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27
44 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
45 INT161507 Tlr4 Positive_regulation of Gene_expression of Il1b 1 0.24 0.19 1.25
46 INT108389 IL1B Positive_regulation of ADAMTS4 1 0.51 1.19 1.24
47 INT70039 IL1B Regulation of Negative_regulation of IL10 1 0.07 1.42 1.21
48 INT70038 IL1B Regulation of PRF1 1 0.05 1.42 1.21
49 INT70031 IL1B Regulation of Negative_regulation of PRF1 1 0.05 1.42 1.21
50 INT70030 IL1B Regulation of IL10 1 0.07 1.42 1.21
51 INT194861 Binding of IL1B and IL1R1 2 0.01 1.55 1.2
52 INT209926 IL1B Regulation of PPARA 1 0.21 2.45 1.2
53 INT55162 Binding of NFKB1 and RELA 10 0.30 2.82 1.18
54 INT289465 IRF6 Positive_regulation of IL1B 3 0.05 0.9 1.16
55 INT94502 Il1b Positive_regulation of Gene_expression of Avp 1 0.28 1.97 1.15
56 INT94509 Il1b Positive_regulation of Gene_expression of AVP 1 0.36 1.96 1.15
57 INT147447 ADCYAP1 Regulation of Localization of RELA 1 0.50 1.12 1.15
58 INT66767 Il1b Positive_regulation of Pla2g10 1 0.05 0.47 1.13
59 INT94498 Il1b Positive_regulation of Gene_expression of Crh 1 0.24 1.94 1.13
60 INT141979 Calca Negative_regulation of Gene_expression of Il1b 1 0.40 0.62 1.13
61 INT66907 Il1b Positive_regulation of Localization of Oxt 2 0.78 0.18 1.12
62 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
63 INT167428 Il1b Positive_regulation of Localization of Gpt 1 0.43 1.31 1.11
64 INT317512 Binding of Oprm1 and Prkca 1 0.07 0.13 1.1
65 INT57982 Il1b Positive_regulation of Crh 2 0.38 0.98 1.09
66 INT107562 Penk Positive_regulation of Localization of Il1b 1 0.20 0.09 1.09
67 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
68 INT74939 IL1B Positive_regulation of Gene_expression of HGF 1 0.58 0.72 1.09
69 INT94500 Tnf Positive_regulation of Gene_expression of Il1b 1 0.25 1.9 1.09
70 INT76396 Il10 Negative_regulation of Il1b 2 0.65 1.89 1.08
71 INT107567 Hps4 Positive_regulation of Localization of Il1b 1 0.01 0.09 1.08
72 INT107564 Hps4 Regulation of Localization of Il1b 1 0.01 0.1 1.07
73 INT107560 Penk Regulation of Localization of Il1b 1 0.18 0.1 1.07
74 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
75 INT338894 TNFSF14 Negative_regulation of Gsk3a 1 0.00 0.54 1.04
76 INT162319 Positive_regulation of F2rl1 Positive_regulation of Il1b 1 0.46 1.6 1.04
77 INT65986 IL1B Positive_regulation of PTGS2 3 0.32 2.05 1.03
78 INT128297 Il1b Positive_regulation of CRH 1 0.02 0.27 1.03
79 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01
80 INT317568 Prkca Regulation of Negative_regulation of Oprm1 1 0.10 0.07 1
81 INT102690 IL1B Positive_regulation of ITGAL 1 0.05 0.87 0.99
82 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98
83 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98
84 INT69307 Prkcq Negative_regulation of TH1L 1 0.00 0.98 0.98
85 INT154255 Tnf Positive_regulation of IL1B 1 0.54 0.94 0.97
86 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
87 INT211745 Gnptab Regulation of Positive_regulation of Prkca 1 0.00 0 0.96
88 INT240123 MIR885 Negative_regulation of IL1B 1 0.01 1.57 0.96
89 INT256357 Phosphorylation of Rela Positive_regulation of Localization of Ik 1 0.00 0.05 0.96
90 INT130722 Binding of IL1B and Nfkb1 1 0.28 1.23 0.95
91 INT123051 Gpbar1 Regulation of Phosphorylation of Prkca 1 0.43 0 0.94
92 INT123050 Prkca Regulation of Phosphorylation of Grk4 1 0.33 0 0.94
93 INT123048 Grk4 Regulation of Phosphorylation of Prkca 1 0.33 0 0.94
94 INT123053 Prkca Regulation of Phosphorylation of Gpbar1 1 0.43 0 0.94
95 INT130725 Binding of IL1B and Il1rn 1 0.01 1.16 0.93
96 INT81919 Binding of HSF1 and IL1B 1 0.42 0.77 0.93
97 INT161655 Gsr Regulation of Gene_expression of Il1b 1 0.20 1.84 0.9
98 INT48341 Negative_regulation of Pde8a Regulation of Ahsg 1 0.22 0 0.9
99 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
100 INT48342 Pde8a Regulation of Ahsg 1 0.24 0 0.9
101 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
102 INT167771 Prkca Positive_regulation of Phosphorylation of Sigmar1 1 0.38 0.23 0.89
103 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88
104 INT136349 Il1b Positive_regulation of Positive_regulation of Oprl1 1 0.22 0.27 0.88
105 INT209928 IL1B Positive_regulation of MAPK14 2 0.15 1.69 0.87
106 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87
107 INT317515 Binding of Hint1 and Prkca 1 0.13 0.17 0.87
108 INT196632 IL1B Positive_regulation of F2RL1 2 0.05 1.52 0.84
109 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84
110 INT184114 Tlr4 Positive_regulation of Socs3 2 0.65 1.14 0.83
111 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83
112 INT10275 Il1b Positive_regulation of Gene_expression of Penk 1 0.49 0.75 0.83
113 INT149626 Il1b Regulation of Gene_expression of Tnf 1 0.41 0.83 0.83
114 INT84717 Il1b Regulation of Cpox 1 0.00 0.37 0.83
115 INT65011 IL1B Positive_regulation of PTGER2 4 0.08 0.92 0.82
116 INT102201 Tnf Regulation of Il1b 3 0.39 2.57 0.82
117 INT317546 Oprm1 Regulation of Prkca 1 0.06 0.4 0.82
118 INT190869 Binding of Prkca and Ltp 1 0.03 0.86 0.81
119 INT83094 IL1B Positive_regulation of Positive_regulation of BDKRB1 1 0.45 0.2 0.81
120 INT157915 Prkca Regulation of Gene_expression of Edn1 1 0.17 0.55 0.81
121 INT282063 Ngf Positive_regulation of Positive_regulation of Prkca 1 0.09 0.18 0.8
122 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8
123 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
124 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78
125 INT157914 Trpv1 Regulation of Prkca 1 0.07 0.55 0.78
126 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78
127 INT157917 TRPV1 Regulation of Prkca 1 0.04 0.55 0.78
128 INT161485 Il1b Regulation of Gene_expression of TGFB1 1 0.47 1.21 0.77
129 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
130 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
131 INT190867 Binding of Marcks and Prkca 1 0.17 0.8 0.77
132 INT161481 Slc7a12 Regulation of Gene_expression of Il1b 1 0.14 1.21 0.77
133 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
134 INT173112 IL1B Positive_regulation of Gene_expression of VCAM1 2 0.43 1.34 0.76
135 INT107602 Binding of OPLL and Enpp1 1 0.15 1.12 0.76
136 INT161482 Il1b Negative_regulation of TGFB1 1 0.45 1.17 0.76
137 INT135180 IL1B Positive_regulation of Gene_expression of TNFSF11 2 0.76 1.73 0.75
138 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
139 INT144299 Il1b Positive_regulation of Oprm1 1 0.42 0.4 0.74
140 INT185140 Elane Positive_regulation of Prkca 1 0.00 0 0.74
141 INT161484 Binding of TGFB1 and Il1b 1 0.37 1.16 0.73
142 INT228494 Binding of Ncoa5 and Rela 1 0.00 1.58 0.72
143 INT262573 Par2 Regulation of Positive_regulation of Prkca 1 0.05 0.57 0.72
144 INT150993 Sfpq Positive_regulation of Gene_expression of Il1b 1 0.04 0.7 0.72
145 INT74941 IL1B Positive_regulation of Gene_expression of PTGER2 1 0.08 0.48 0.72
146 INT65985 IL1B Positive_regulation of Gene_expression of PTGS2 3 0.23 2.62 0.71
147 INT262581 Prkca Positive_regulation of Phosphorylation of Trpv1 1 0.13 0.28 0.71
148 INT73822 TAC1 Positive_regulation of Localization of IL1B 1 0.04 0.56 0.71
149 INT153123 NFKBIA Negative_regulation of Phosphorylation of RELA 1 0.03 2.01 0.71
150 INT262574 Gnaq Positive_regulation of Prkca 1 0.00 0.57 0.71
151 INT73824 TFF2 Positive_regulation of Localization of IL1B 1 0.02 0.56 0.71
152 INT83838 Binding of CEACAM6 and Il1b 1 0.05 0 0.71
153 INT113500 IL1B Positive_regulation of Gene_expression of BHLHE23 1 0.18 0.1 0.71
154 INT95148 CEL Regulation of IL1B 1 0.24 0.88 0.7
155 INT334395 IL1B Positive_regulation of Tnf 1 0.11 2.83 0.69
156 INT250932 IL1B Regulation of Gene_expression of BDNF 1 0.06 0.24 0.69
157 INT346233 PREP Regulation of IL1B 1 0.05 1.44 0.69
158 INT172142 IL10 Positive_regulation of Protein_catabolism of IL1B 2 0.03 1.69 0.68
159 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 0.02 1.69 0.68
160 INT66537 IL1B Positive_regulation of Gene_expression of Fos 1 0.02 0 0.68
161 INT70998 IL1B Regulation of Gene_expression of Icam1 1 0.44 0.95 0.67
162 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
163 INT150994 Sfpq Negative_regulation of Gene_expression of Il1b 1 0.03 0.69 0.66
164 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66
165 INT88194 ZAK Positive_regulation of Gene_expression of IL1B 1 0.07 0.94 0.66
166 INT152111 IL1B Negative_regulation of Ltp 1 0.03 0.85 0.66
167 INT270763 IL1B Negative_regulation of IKBKB 1 0.04 1.13 0.66
168 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 0.04 0.62 0.65
169 INT184193 HRAS Negative_regulation of Gene_expression of IL1B 1 0.00 1.12 0.65
170 INT97508 Negative_regulation of Il1b Positive_regulation of Crh 1 0.31 0.89 0.65
171 INT58229 Il1b Regulation of Gene_expression of Fam166a 1 0.01 0 0.64
172 INT254199 Il10 Positive_regulation of Gene_expression of Socs3 2 0.06 0.75 0.63
173 INT172139 IL4 Negative_regulation of IL1B 1 0.02 0.85 0.63
174 INT60328 Il1b Positive_regulation of Tnf 2 0.29 1.84 0.62
175 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62
176 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62
177 INT61826 Tnf Negative_regulation of Il1b 1 0.39 0.89 0.62
178 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61
179 INT103214 Binding of Il1b and Pnoc 1 0.40 0.23 0.61
180 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61
181 INT132731 Positive_regulation of Binding of Il1b and Il6 1 0.46 1.2 0.61
182 INT128814 Ephb1 Negative_regulation of Gene_expression of Il1b 1 0.02 0.37 0.61
183 INT66768 Il1b Positive_regulation of Transcription of Pla2g10 1 0.05 0.22 0.6
184 INT221246 Prkca Negative_regulation of Ptpn2 1 0.04 0.54 0.6
185 INT105848 Il1b Positive_regulation of Gene_expression of Cpox 1 0.12 0.41 0.59
186 INT81915 HSF1 Negative_regulation of IL1B 1 0.51 0.65 0.59
187 INT81917 HSF1 Positive_regulation of IL1B 1 0.41 0.65 0.59
188 INT128810 Il1b Positive_regulation of Gene_expression of Nos2 1 0.04 0.31 0.59
189 INT96240 Il13 Negative_regulation of Il1b 1 0.17 0.6 0.59
190 INT96242 Il13 Negative_regulation of Gene_expression of Il1b 1 0.15 0.67 0.59
191 INT128603 Il1b Positive_regulation of Gene_expression of Fos 1 0.50 0.59 0.58
192 INT58342 Calca Negative_regulation of Localization of IL1B 1 0.00 0.6 0.58
193 INT54620 IL1B Positive_regulation of Crh 1 0.01 0.39 0.58
194 INT176471 TNF Positive_regulation of Gene_expression of IL1B 1 0.02 0.61 0.57
195 INT108387 IL1B Positive_regulation of Localization of MMP1 1 0.27 0.3 0.57
196 INT143938 Il1rn Negative_regulation of Il1b 1 0.04 0.52 0.57
197 INT60665 Il1b Regulation of Oprd1 1 0.05 0 0.57
198 INT58805 Il1b Negative_regulation of LH 1 0.24 0 0.56
199 INT146112 Binding of Il1b and Tnf 1 0.32 1.19 0.56
200 INT94745 Tlr4 Positive_regulation of Transcription of Il1b 1 0.15 0.48 0.56

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of insulin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of insulin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97
2 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
3 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03
4 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9
5 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
6 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35
7 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56
8 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35
9 INT6849 Localization of IL1B 229 0.81 112.56 69.63
10 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
11 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86
12 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82
13 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
14 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48
15 INT5973 Regulation of IL1B 109 0.62 66.6 39.88
16 INT6484 Binding of IL1B 122 0.47 75.84 35.07
17 INT9347 Localization of Il1b 58 0.81 26.13 31.53
18 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
19 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29
20 INT10273 Positive_regulation of Gene_expression of Il1b 47 0.68 31.15 26.21
21 INT5948 Regulation of Il1b 44 0.60 22.8 25.4
22 INT10349 Negative_regulation of Il1b 48 0.58 25.53 24.24
23 INT51029 Negative_regulation of Il1b 34 0.57 29.34 23.62
24 INT48081 Localization of Il1b 46 0.80 21.59 22.4
25 INT117527 Binding of Prkca 25 0.48 6.43 21.05
26 INT9237 Regulation of Gene_expression of IL1B 49 0.62 30.69 20.34
27 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15
28 INT36054 Transcription of IL1B 53 0.72 32.64 17.31
29 INT79458 Localization of Prkca 30 0.81 11.13 15.78
30 INT142464 Gene_expression of Socs3 58 0.77 52.04 15.34
31 INT93482 Localization of Rela 56 0.78 24.52 14.82
32 INT25266 Positive_regulation of Localization of IL1B 38 0.69 15.89 14.35
33 INT29170 Negative_regulation of Gene_expression of Il1b 25 0.59 16.36 13.68
34 INT19191 Negative_regulation of Localization of IL1B 35 0.58 15.19 13.63
35 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36
36 INT144646 Positive_regulation of Rela 53 0.67 27.78 13.2
37 INT58226 Negative_regulation of Gene_expression of Il1b 24 0.57 18.09 12.68
38 INT51028 Regulation of Il1b 28 0.60 21.15 12.47
39 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8
40 INT50196 Transcription of Il1b 25 0.69 19.08 10.43
41 INT112940 Negative_regulation of Positive_regulation of Prkca 12 0.45 5.85 10
42 INT102865 Positive_regulation of Positive_regulation of Prkca 25 0.69 8.34 9.9
43 INT48078 Regulation of Gene_expression of Il1b 15 0.62 14.78 9.53
44 INT66213 Localization of RELA 63 0.78 14.71 8.77
45 INT142462 Positive_regulation of Gene_expression of Socs3 23 0.68 23.27 8.27
46 INT66926 Transcription of Il1b 15 0.69 13.16 7.81
47 INT48077 Positive_regulation of Localization of Il1b 17 0.69 8.8 7.68
48 INT50195 Positive_regulation of Positive_regulation of Il1b 12 0.67 7.41 7.64
49 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26
50 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84
51 INT48076 Negative_regulation of Localization of Il1b 10 0.59 3.46 6.58
52 INT256345 Phosphorylation of Rela 21 0.75 9.51 6.56
53 INT48954 Positive_regulation of Localization of Il1b 13 0.53 8.16 6.44
54 INT67130 Negative_regulation of Localization of Il1b 7 0.57 1.36 6.42
55 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
56 INT84716 Negative_regulation of Positive_regulation of Il1b 9 0.57 5.34 6.27
57 INT116641 Phosphorylation of Gsk3a 12 0.71 4.3 6.22
58 INT53871 Gene_expression of Socs1 32 0.71 22.83 6.21
59 INT80750 Binding of Il1b 11 0.47 7.97 5.95
60 INT224530 Positive_regulation of Enpp1 12 0.70 7.03 5.82
61 INT123045 Negative_regulation of Phosphorylation of Prkca 9 0.46 5.73 5.77
62 INT42378 Positive_regulation of Socs3 21 0.67 15.81 5.71
63 INT55578 Regulation of Gene_expression of Il1b 7 0.62 4.74 5.55
64 INT10705 Binding of Il1b 9 0.36 2.8 5.53
65 INT50197 Positive_regulation of Transcription of Il1b 11 0.50 8.95 5.41
66 INT57441 Positive_regulation of Phosphorylation of Prkca 9 0.40 2.72 4.89
67 INT83205 Negative_regulation of Negative_regulation of Prkca 6 0.43 1.14 4.87
68 INT64160 Negative_regulation of Gene_expression of Prkca 8 0.43 3.01 4.72
69 INT79460 Positive_regulation of Localization of Prkca 11 0.70 2.72 4.71
70 INT16047 Negative_regulation of Positive_regulation of Il1b 11 0.57 5.27 4.66
71 INT128746 Negative_regulation of Gsk3a 11 0.52 8.43 4.61
72 INT55171 Gene_expression of RELA 80 0.75 17.17 4.47
73 INT93483 Negative_regulation of Localization of Rela 11 0.57 5.1 4.19
74 INT48080 Positive_regulation of Positive_regulation of Il1b 5 0.50 4.3 4.19
75 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
76 INT19190 Regulation of Localization of IL1B 14 0.50 8.71 4.12
77 INT158377 Positive_regulation of Positive_regulation of Rela 6 0.49 3.08 4.11
78 INT76466 Regulation of Gene_expression of Prkca 6 0.45 0.94 3.91
79 INT118154 Positive_regulation of Binding of Prkca 2 0.50 0.58 3.81
80 INT133550 Negative_regulation of Gene_expression of Rela 14 0.40 4.64 3.73
81 INT154225 Negative_regulation of Binding of Prkca 2 0.30 0.06 3.71
82 INT195527 Binding of Rela 17 0.25 4.42 3.56
83 INT83206 Regulation of Regulation of Prkca 3 0.45 1.34 3.46
84 INT73557 Positive_regulation of RELA 57 0.46 8.7 3.43
85 INT122997 Phosphorylation of Rps6kb1 46 0.72 9.92 3.43
86 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
87 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
88 INT68445 Gene_expression of ENPP1 10 0.70 10.8 3.3
89 INT118153 Regulation of Positive_regulation of Prkca 5 0.45 3.15 3.23
90 INT133557 Transcription of Rela 6 0.52 3.86 3.2
91 INT66922 Positive_regulation of Transcription of Il1b 7 0.49 6.58 3.14
92 INT190860 Regulation of Localization of Prkca 4 0.21 1.61 3.11
93 INT66212 Negative_regulation of Localization of RELA 13 0.57 2.48 3.09
94 INT228677 Negative_regulation of Phosphorylation of Rps6kb1 24 0.51 3.88 2.97
95 INT207851 Regulation of Enpp1 5 0.45 4.42 2.96
96 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
97 INT15157 Gene_expression of INPP5K 30 0.67 15.49 2.85
98 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
99 INT6479 Negative_regulation of Binding of IL1B 10 0.43 5.1 2.78
100 INT112147 Positive_regulation of Negative_regulation of Il1b 3 0.49 3.42 2.77
101 INT184005 Negative_regulation of Gene_expression of Socs3 6 0.48 8.76 2.74
102 INT153221 Positive_regulation of Rela 5 0.16 2.16 2.72
103 INT10350 Negative_regulation of Regulation of Il1b 3 0.41 0.58 2.69
104 INT11379 Positive_regulation of Negative_regulation of IL1B 9 0.49 7.2 2.64
105 INT67618 Positive_regulation of Inpp5k 3 0.45 0.77 2.64
106 INT142465 Negative_regulation of Socs3 8 0.48 8.31 2.62
107 INT15144 Protein_catabolism of IL1B 11 0.92 4.67 2.58
108 INT63846 Gene_expression of Prkcq 1 0.73 1.11 2.58
109 INT184583 Regulation of Phosphorylation of Prkca 3 0.21 1.76 2.5
110 INT141195 Negative_regulation of Rela 14 0.29 8.61 2.44
111 INT162518 Positive_regulation of Localization of Rela 12 0.47 1.96 2.41
112 INT92000 Gene_expression of Gsk3a 12 0.18 4.12 2.39
113 INT107597 Binding of Enpp1 5 0.37 3.35 2.23
114 INT121589 Negative_regulation of GSK3A 10 0.53 9.11 2.22
115 INT184054 Negative_regulation of Gene_expression of Socs1 7 0.53 9.18 2.22
116 INT36055 Positive_regulation of Transcription of IL1B 9 0.49 6.24 2.21
117 INT73906 Regulation of Transcription of IL1B 5 0.56 3.46 2.1
118 INT55035 Negative_regulation of Negative_regulation of Il1b 4 0.43 1.46 2.02
119 INT168275 Phosphorylation of Il1b 1 0.79 2.39 2.01
120 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
121 INT123530 Phosphorylation of RELA 9 0.80 3.46 1.99
122 INT316778 Positive_regulation of Gene_expression of ENPP1 1 0.62 7.2 1.97
123 INT102866 Regulation of Negative_regulation of Prkca 2 0.43 1.27 1.95
124 INT171323 Phosphorylation of IL1B 5 0.57 4.13 1.94
125 INT116033 Negative_regulation of Transcription of Il1b 4 0.42 2.05 1.94
126 INT184042 Negative_regulation of Socs1 9 0.46 8.1 1.88
127 INT170345 Negative_regulation of Localization of Prkca 5 0.23 0.88 1.88
128 INT144649 Negative_regulation of Positive_regulation of Rela 11 0.26 8.27 1.87
129 INT109059 Gene_expression of PRKCZ 2 0.65 0.64 1.87
130 INT224529 Positive_regulation of Gene_expression of Enpp1 15 0.70 12.75 1.81
131 INT14246 Regulation of Positive_regulation of IL1B 7 0.44 3.04 1.77
132 INT55169 Binding of RELA 40 0.36 4.91 1.74
133 INT184068 Positive_regulation of Socs1 7 0.51 4.03 1.73
134 INT108875 Positive_regulation of Localization of RELA 9 0.49 1.43 1.72
135 INT116498 Negative_regulation of Negative_regulation of IL1B 7 0.41 3.08 1.7
136 INT254250 Regulation of Socs1 5 0.06 3.04 1.66
137 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
138 INT256341 Positive_regulation of Phosphorylation of Rela 5 0.46 2.12 1.62
139 INT73901 Negative_regulation of Transcription of IL1B 3 0.53 0.46 1.57
140 INT261849 Positive_regulation of Phosphorylation of Gsk3a 3 0.14 1.15 1.57
141 INT184052 Localization of Socs1 3 0.59 4.07 1.54
142 INT118149 Positive_regulation of Binding of Prkcz 1 0.09 0.58 1.54
143 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
144 INT141455 Negative_regulation of Inpp5k 2 0.36 1.09 1.51
145 INT332460 Regulation of Binding of Enpp1 1 0.05 0.78 1.5
146 INT184032 Regulation of Socs3 6 0.37 4.08 1.48
147 INT118150 Positive_regulation of Positive_regulation of Prkcz 1 0.08 0.49 1.42
148 INT133552 Negative_regulation of Transcription of Rela 2 0.23 2.43 1.34
149 INT125296 Regulation of Inpp5k 1 0.22 0 1.32
150 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
151 INT110252 Positive_regulation of Gene_expression of RELA 29 0.49 6.36 1.31
152 INT163506 Binding of Gsk3a 4 0.32 1.41 1.31
153 INT153220 Negative_regulation of Positive_regulation of Rela 1 0.09 0.31 1.31
154 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
155 INT94744 Regulation of Transcription of Il1b 3 0.44 2.83 1.26
156 INT107599 Negative_regulation of Enpp1 8 0.51 6.02 1.24
157 INT63849 Regulation of Gene_expression of Prkcq 1 0.58 0.62 1.24
158 INT63847 Regulation of Prkcq 1 0.42 0.5 1.23
159 INT202476 Positive_regulation of Gene_expression of Rela 10 0.34 3.65 1.22
160 INT173114 Positive_regulation of Binding of IL1B 6 0.49 2.56 1.22
161 INT184056 Regulation of Gene_expression of Socs3 4 0.45 4.24 1.22
162 INT228670 Negative_regulation of Rps6kb1 12 0.38 5.27 1.21
163 INT143846 Positive_regulation of INPP5K 5 0.40 6.4 1.17
164 INT118258 Positive_regulation of ENPP1 3 0.62 4.26 1.16
165 INT48338 Gene_expression of Ahsg 2 0.52 0.25 1.16
166 INT63856 Positive_regulation of Gene_expression of Prkcq 1 0.47 0.53 1.16
167 INT179884 Gene_expression of SOCS3 10 0.67 16.57 1.14
168 INT163914 Positive_regulation of Prkcd 1 0.67 1.43 1.12
169 INT62237 Gene_expression of Ptprf 2 0.65 1.63 1.08
170 INT184020 Localization of Socs3 3 0.75 4.05 1.06
171 INT9348 Regulation of Localization of Il1b 2 0.27 0.14 1.04
172 INT25264 Regulation of Negative_regulation of IL1B 3 0.27 1.17 1.02
173 INT50989 Regulation of Positive_regulation of Il1b 2 0.42 0.86 1.02
174 INT145864 Gene_expression of Irs1 5 0.71 3.34 1.01
175 INT346201 Negative_regulation of Phosphorylation of IL1B 1 0.20 1.69 1.01
176 INT158375 Positive_regulation of Transcription of Rela 2 0.45 0.8 0.94
177 INT168280 Positive_regulation of Phosphorylation of Il1b 1 0.49 1.1 0.93
178 INT253940 Gene_expression of Gsk3a 1 0.08 2.82 0.92
179 INT248678 Gene_expression of Rela 4 0.16 2.35 0.9
180 INT253938 Positive_regulation of Gsk3a 3 0.06 3.4 0.9
181 INT167763 Negative_regulation of Prkcz 1 0.04 0.32 0.88
182 INT89669 Negative_regulation of Positive_regulation of Prkcq 1 0.08 0.23 0.87
183 INT317485 Regulation of Binding of Prkca 1 0.17 0.17 0.87
184 INT91995 Positive_regulation of Gsk3a 8 0.14 2.84 0.86
185 INT120393 Negative_regulation of PRKCD 3 0.22 1.07 0.86
186 INT33495 Regulation of Ahsg 1 0.23 0 0.86
187 INT48339 Regulation of Localization of Ahsg 1 0.21 0 0.86
188 INT89668 Positive_regulation of Prkcq 1 0.09 0.22 0.86
189 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85
190 INT48337 Localization of Ahsg 1 0.54 0 0.85
191 INT120396 Positive_regulation of Localization of PRKCD 1 0.26 0.42 0.85
192 INT184014 Binding of Socs1 2 0.34 0.97 0.84
193 INT307469 Regulation of Gsk3a 4 0.09 1.12 0.83
194 INT109060 Regulation of Gene_expression of PRKCZ 1 0.03 0 0.83
195 INT120392 Localization of PRKCD 1 0.39 0.4 0.83
196 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81
197 INT184026 Binding of Socs3 7 0.42 1.93 0.81
198 INT174069 Positive_regulation of Rps6kb1 14 0.61 3.7 0.77
199 INT256349 Regulation of Phosphorylation of Rela 3 0.31 0.26 0.77
200 INT321433 Negative_regulation of IRS1 3 0.32 5.41 0.75
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