GO:0046628

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Name positive regulation of insulin receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0046628
Unique Molecular Interactions 652
Total Molecular Interactions 874
Total Single Events 9234
Pain Genes Associated 19

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of insulin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of insulin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
2 INT83169 Binding of Cck and Lep 7 0.42 1.58 2.78
3 INT278948 LEP Positive_regulation of Gene_expression of PTGER2 1 0.09 4.04 2.69
4 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
5 INT83170 Lep Regulation of Cck 5 0.43 0.68 1.96
6 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
7 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57
8 INT41100 Mdk Positive_regulation of Localization of INS 1 0.01 0 1.55
9 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
10 INT340300 Ea1 Positive_regulation of Gene_expression of Sirt1 1 0.08 1.68 1.49
11 INT317569 Prkca Positive_regulation of Phosphorylation of Src 1 0.11 0 1.25
12 INT249487 Binding of Ephb1 and Src 1 0.17 0.74 1.23
13 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2
14 INT249488 Positive_regulation of Binding of Ephb1 and Src 1 0.23 0.68 1.12
15 INT121743 Negative_regulation of Src Negative_regulation of Ephb1 1 0.27 0 1.02
16 INT117311 HP Positive_regulation of Lep 1 0.00 1.78 1.01
17 INT278962 LEP Positive_regulation of CPOX 1 0.05 1.33 1
18 INT317518 Src Regulation of Negative_regulation of Oprm1 1 0.16 0.07 1
19 INT143915 Src Regulation of Rbm39 1 0.03 0.18 0.99
20 INT40424 CCK Regulation of Localization of INS 1 0.02 0 0.97
21 INT75283 SST Negative_regulation of Localization of INS 2 0.47 1.45 0.96
22 INT121744 Src Positive_regulation of Positive_regulation of Ephb1 1 0.35 0 0.96
23 INT278940 LEP Positive_regulation of Gene_expression of IL8 1 0.34 1.68 0.96
24 INT122269 Src Negative_regulation of Positive_regulation of Grin2b 1 0.27 0.44 0.92
25 INT122266 Src Negative_regulation of Grin2b 1 0.27 0.43 0.91
26 INT167767 Prkcz Positive_regulation of Phosphorylation of Sigmar1 1 0.04 0.23 0.9
27 INT167766 Prkcz Positive_regulation of Positive_regulation of Sigmar1 1 0.04 0.23 0.9
28 INT109103 MMP2 Positive_regulation of INS 1 0.33 1.07 0.89
29 INT249491 Efnb2 Positive_regulation of Phosphorylation of Src 1 0.01 0.5 0.87
30 INT340294 Ea1 Positive_regulation of Sirt1 1 0.06 0.53 0.83
31 INT317513 Oprm1 Regulation of Positive_regulation of Src 1 0.09 0.4 0.82
32 INT317570 Oprm1 Regulation of Src 1 0.04 0.4 0.82
33 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8
34 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
35 INT130948 Amt Regulation of Gene_expression of LEP 1 0.00 1.04 0.78
36 INT130949 Amt Regulation of LEP 1 0.00 1.04 0.77
37 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
38 INT167770 Sigmar1 Positive_regulation of Prkcz 1 0.04 0.34 0.77
39 INT316544 BCL2L11 Regulation of INS 1 0.00 1.36 0.77
40 INT167768 Regulation of Sigmar1 Positive_regulation of Prkcz 1 0.02 0.34 0.77
41 INT278958 LEP Positive_regulation of IL1B 1 0.33 1.91 0.74
42 INT41165 Gtf3a Regulation of INS 1 0.00 0.15 0.74
43 INT214163 Binding of Lep and Nts 1 0.04 0.21 0.74
44 INT41164 Binding of INS and SST 1 0.07 0.14 0.73
45 INT31643 POMC Regulation of INS 1 0.59 0.62 0.73
46 INT317547 Src Positive_regulation of Positive_regulation of Grin1 1 0.17 0 0.72
47 INT148453 Gene_expression of Inhbe Positive_regulation of Src 1 0.06 0.68 0.72
48 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69
49 INT278956 LEP Regulation of Gene_expression of IL8 1 0.30 1.11 0.69
50 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
51 INT278951 LEP Regulation of Gene_expression of PTGER2 1 0.07 1.11 0.69
52 INT278965 LEP Positive_regulation of Gene_expression of NOS2 2 0.29 2.12 0.66
53 INT249489 Src Negative_regulation of Phosphorylation of Grin2b 1 0.20 0.63 0.66
54 INT323773 Binding of Il6 and Lep 1 0.29 3.54 0.6
55 INT242883 INS Negative_regulation of Gene_expression of TLR2 1 0.17 2.35 0.6
56 INT29847 INS Regulation of Localization of AVP 1 0.23 0.24 0.59
57 INT291262 Positive_regulation of INS Positive_regulation of Mapk1 1 0.03 1.78 0.58
58 INT100225 Binding of Egf and Src 1 0.01 0.67 0.58
59 INT291258 INS Positive_regulation of Mapk1 1 0.04 1.77 0.58
60 INT103165 NGF Positive_regulation of Localization of INS 1 0.05 0 0.58
61 INT349083 Binding of Lep and Rtn1 1 0.09 1.68 0.57
62 INT91339 Binding of Lep and Cck 1 0.28 0.34 0.56
63 INT113162 Lep Positive_regulation of Positive_regulation of Insrr 1 0.03 0 0.55
64 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55
65 INT204087 IL1B Positive_regulation of Gene_expression of LEP 1 0.09 2.6 0.54
66 INT29252 Regulation of INS Positive_regulation of GH1 1 0.26 0.08 0.54
67 INT214160 Binding of Lep and Mc4r 1 0.29 1.31 0.53
68 INT214143 Binding of Lep and Pomc 1 0.27 1.2 0.53
69 INT29253 INS Positive_regulation of GH1 1 0.44 0.08 0.53
70 INT311767 INS Negative_regulation of Gene_expression of SLC1A3 1 0.52 0 0.52
71 INT160203 Prkcc Positive_regulation of Src 1 0.02 0 0.51
72 INT98737 Src Negative_regulation of Tk1 1 0.22 0.15 0.5
73 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5
74 INT162890 Negative_regulation of Binding of LEP and Tnf 1 0.03 0.49 0.48
75 INT162889 Binding of LEP and Tnf 1 0.03 0.49 0.48
76 INT101001 GHRH Regulation of Localization of INS 1 0.28 0 0.47
77 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
78 INT340296 Ea1 Regulation of Gene_expression of Sirt1 1 0.08 0.15 0.46
79 INT110476 EDN1 Positive_regulation of Localization of PRKCZ 1 0.25 0.07 0.46
80 INT132509 Binding of LEP and Cck 1 0.13 0.16 0.45
81 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
82 INT323880 Binding of BMI1 and LEP 1 0.02 3.97 0.41
83 INT240618 Binding of INS and ADIPOQ 3 0.17 2.54 0.4
84 INT83171 Cck Regulation of Lep 1 0.30 0.09 0.4
85 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
86 INT97395 Lep Positive_regulation of Stat3 1 0.67 0.42 0.4
87 INT29052 Binding of INS and INSRR 1 0.02 0.23 0.4
88 INT29053 Regulation of Binding of INS and INSRR 1 0.01 0.24 0.4
89 INT78621 PRL Positive_regulation of Localization of INS 2 0.06 0.5 0.39
90 INT291256 INS Negative_regulation of Positive_regulation of Mdk 1 0.01 1.65 0.39
91 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
92 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
93 INT300488 Binding of CRP and LEP 1 0.46 2.03 0.37
94 INT143917 Binding of Src and Arrb2 1 0.27 0.07 0.37
95 INT156122 Phosphorylation of Src Positive_regulation of Adrbk1 1 0.01 0 0.37
96 INT263380 Binding of Src and Abl1 1 0.21 0 0.37
97 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
98 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36
99 INT278966 MAPK14 Positive_regulation of Gene_expression of LEP 1 0.16 0.62 0.36
100 INT278949 JAK3 Positive_regulation of Gene_expression of LEP 1 0.42 0.63 0.36
101 INT143918 Binding of Src and Rbm39 1 0.02 0.07 0.36
102 INT4382 RIPK2 Regulation of INS 1 0.12 0.58 0.36
103 INT263434 Src Regulation of Abl1 1 0.02 0.29 0.35
104 INT323885 LEP Regulation of Gene_expression of NOS2 1 0.26 1.07 0.35
105 INT213484 Binding of Lep and Pik3c3 1 0.01 0 0.35
106 INT183786 IL6 Negative_regulation of INS 1 0.09 1.61 0.35
107 INT263382 Src Regulation of Trib3 1 0.00 0.29 0.35
108 INT183784 INS Negative_regulation of Binding of TBK1 1 0.01 1.81 0.34
109 INT183783 INS Negative_regulation of TBK1 1 0.01 1.81 0.34
110 INT183793 INS Negative_regulation of Binding of Ros1 1 0.16 1.66 0.34
111 INT183785 INS Positive_regulation of Gene_expression of NFKBIB 1 0.03 1.83 0.34
112 INT183780 INS Negative_regulation of Gene_expression of CYBB 1 0.02 1.74 0.34
113 INT4381 RIPK2 Positive_regulation of Localization of INS 1 0.13 0.53 0.34
114 INT183782 INS Negative_regulation of Gene_expression of TBK1 1 0.01 1.81 0.34
115 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
116 INT207184 Binding of Adipoq and Lep 1 0.25 2.45 0.33
117 INT323870 LEP Regulation of Gene_expression of MMP13 1 0.21 1.76 0.33
118 INT303993 Lep Positive_regulation of Gene_expression of IL2 1 0.15 0.24 0.33
119 INT249490 Phosphorylation of Ephb2 Positive_regulation of Src 1 0.17 0.15 0.33
120 INT190683 Binding of A2M and INS 4 0.11 4.97 0.32
121 INT238895 Binding of CRP and INS 1 0.00 0.93 0.32
122 INT105873 Ins1 Negative_regulation of Positive_regulation of Lep 1 0.27 0.67 0.31
123 INT278942 LEP Regulation of IL6 1 0.29 0.61 0.31
124 INT278939 LEP Regulation of IL8 1 0.13 0.61 0.31
125 INT213485 Lep Positive_regulation of Localization of Grin2a 1 0.19 0 0.31
126 INT249480 Positive_regulation of Ephb1 Positive_regulation of Phosphorylation of Src 1 0.22 0.23 0.31
127 INT278969 LEP Regulation of PTGER2 1 0.03 0.6 0.31
128 INT105874 Lep Negative_regulation of Positive_regulation of Ins1 1 0.27 0.67 0.31
129 INT226989 Lias Regulation of Gene_expression of Lep 1 0.10 0.91 0.3
130 INT278961 IL6 Regulation of Gene_expression of LEP 1 0.29 0.89 0.3
131 INT191240 SAE1 Regulation of Localization of INS 1 0.08 1.15 0.3
132 INT51275 IGF1 Negative_regulation of INS 2 0.35 0.98 0.29
133 INT303983 Lep Positive_regulation of CXCL10 1 0.06 0.31 0.29
134 INT333886 Binding of Lep and Positive_regulation of Gene_expression of Nos2 1 0.39 0.73 0.29
135 INT303998 Lep Positive_regulation of Localization of IL1RAPL1 1 0.04 0.31 0.29
136 INT333887 Binding of Lep and Positive_regulation of Gene_expression of Il1 1 0.17 0.73 0.29
137 INT303995 Lep Positive_regulation of PSME1 1 0.09 0.32 0.29
138 INT163903 Binding of EFNB1 and Src 1 0.03 0.56 0.29
139 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
140 INT246841 Binding of Irs1 and Ppp1r13b 5 0.16 0.94 0.28
141 INT303984 Lep Positive_regulation of Gene_expression of IL8 1 0.06 0.85 0.28
142 INT71550 GTPBP4 Regulation of Localization of INS 1 0.00 0.16 0.28
143 INT291201 Regulation of INS Positive_regulation of GOPC 1 0.00 0.35 0.28
144 INT291200 INS Positive_regulation of GOPC 1 0.01 0.3 0.28
145 INT242878 INS Negative_regulation of Gene_expression of SPI1 1 0.04 1.81 0.27
146 INT224406 INS Regulation of Localization of PYY 1 0.11 0.27 0.27
147 INT224405 INS Regulation of Localization of CCK 1 0.12 0.27 0.27
148 INT249493 Binding of Grin2b and Src 1 0.17 0.15 0.26
149 INT100531 Cck Positive_regulation of Lep 1 0.70 0.15 0.26
150 INT74433 Binding of INS and Cpe 2 0.03 0 0.25
151 INT228611 Binding of DNMT3B and LEP 1 0.04 0 0.25
152 INT291261 INS Positive_regulation of Phosphorylation of Mdk 1 0.01 0.28 0.25
153 INT218732 Lep Regulation of Gene_expression of Trh 1 0.19 0.18 0.25
154 INT309888 INS Positive_regulation of Gene_expression of FAAH 1 0.04 1.19 0.25
155 INT125748 Binding of LEP and Gh 1 0.00 0.52 0.24
156 INT242875 INS Negative_regulation of Gene_expression of TLR4 1 0.11 1.41 0.24
157 INT215037 Ghrh Regulation of Localization of Igf2 1 0.04 2.12 0.24
158 INT334390 ADIPOQ Positive_regulation of Localization of INS 1 0.09 1.3 0.23
159 INT87750 IGFBP3 Negative_regulation of INS 1 0.11 0.86 0.23
160 INT63196 INS Positive_regulation of IL2 1 0.10 0.3 0.23
161 INT63203 INS Positive_regulation of ESR1 1 0.09 0.3 0.23
162 INT63195 INS Positive_regulation of CD8A 1 0.19 0.3 0.23
163 INT63199 INS Positive_regulation of PGR 1 0.11 0.3 0.23
164 INT306795 Binding of LEP and SFTPD 1 0.08 1.13 0.23
165 INT303988 Lep Positive_regulation of Gene_expression of ISYNA1 1 0.06 0.55 0.23
166 INT328382 Positive_regulation of Ghrl Positive_regulation of Localization of INS 1 0.03 1.08 0.23
167 INT108808 Binding of IAPP and INS 1 0.32 1.36 0.23
168 INT323883 BMI1 Regulation of LEP 1 0.02 2.39 0.23
169 INT207845 Binding of INS and Hypism 3 0.04 2.88 0.22
170 INT255044 GLP1R Positive_regulation of Localization of INS 3 0.49 1.47 0.22
171 INT34773 GH1 Regulation of IGF2 1 0.31 0.05 0.22
172 INT102937 Gnrh1 Positive_regulation of Gene_expression of Lep 1 0.50 0 0.22
173 INT214481 ROS1 Negative_regulation of Gene_expression of INS 1 0.00 0.37 0.22
174 INT39263 POMC Negative_regulation of INS 1 0.23 0.6 0.22
175 INT110653 Lep Regulation of Localization of Cck 1 0.06 0.22 0.22
176 INT269180 LEP Positive_regulation of Localization of TNF 1 0.01 0.99 0.21
177 INT257397 Binding of FGD1 and INS 1 0.07 0.27 0.21
178 INT323873 LEP Regulation of Gene_expression of TIMP2 1 0.31 0.63 0.21
179 INT207185 Binding of Bmi1 and Lep 1 0.01 1.7 0.21
180 INT355103 Binding of Ins2 and Ins1 1 0.12 2 0.21
181 INT222482 Lep Positive_regulation of Localization of Gh1 1 0.02 1.02 0.2
182 INT74437 Negative_regulation of Cpe Positive_regulation of Localization of INS 1 0.06 0 0.2
183 INT304001 Lep Negative_regulation of ICAM3 1 0.07 0.35 0.2
184 INT78622 POMC Positive_regulation of Localization of INS 1 0.07 0 0.2
185 INT3592 INS Positive_regulation of AVP 1 0.05 0.28 0.2
186 INT339901 Binding of INS and SCN5A 1 0.01 0.18 0.2
187 INT333889 Lep Regulation of Col7a1 1 0.04 0.41 0.2
188 INT3591 Negative_regulation of INS Positive_regulation of AVP 1 0.04 0.28 0.2
189 INT74439 Negative_regulation of Cpe Positive_regulation of INS 1 0.06 0 0.2
190 INT303979 Lep Positive_regulation of ITGB2 1 0.11 0.35 0.2
191 INT256576 Lep Regulation of Localization of Ins1 1 0.57 2.08 0.2
192 INT303991 Lep Negative_regulation of SELL 1 0.04 0.35 0.2
193 INT217661 LEP Positive_regulation of INS 2 0.25 1.85 0.19
194 INT217665 ADIPOQ Positive_regulation of INS 2 0.06 1.8 0.19
195 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19
196 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19
197 INT303964 Lep Positive_regulation of Icam1 1 0.24 0.35 0.19
198 INT110717 CGA Positive_regulation of Localization of INS 1 0.03 0.5 0.19
199 INT32395 POMC Positive_regulation of INS 1 0.41 0.52 0.19
200 INT333888 Lep Regulation of Localization of GAG 1 0.68 0.38 0.19

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of insulin receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of insulin receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT812 Localization of INS 1026 0.81 515.6 145.31
2 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01
3 INT251 Regulation of INS 398 0.62 232.47 55.04
4 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43
5 INT17881 Gene_expression of LEP 278 0.78 221.61 48.31
6 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98
7 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52
8 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61
9 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79
10 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12
11 INT76123 Gene_expression of Lep 193 0.78 94.17 22.76
12 INT82434 Positive_regulation of LEP 117 0.70 95.45 20.22
13 INT62681 Negative_regulation of LEP 93 0.59 66.97 15.77
14 INT75908 Regulation of LEP 77 0.60 60.16 15.19
15 INT14572 Binding of INS 205 0.48 175.43 13.38
16 INT89842 Phosphorylation of Src 34 0.69 9.57 13.08
17 INT8210 Positive_regulation of Gene_expression of INS 188 0.68 146.57 12.83
18 INT73641 Regulation of Lep 45 0.62 26.2 12.59
19 INT126743 Positive_regulation of Gene_expression of LEP 61 0.66 50.02 11.17
20 INT82079 Positive_regulation of Lep 79 0.70 40 11.07
21 INT4605 Negative_regulation of Gene_expression of INS 220 0.58 139.66 10.75
22 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95
23 INT82078 Negative_regulation of Lep 54 0.59 20.47 9.38
24 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01
25 INT82082 Localization of Lep 63 0.81 26.41 8.56
26 INT75907 Binding of LEP 53 0.46 46.65 8.44
27 INT4606 Regulation of Gene_expression of INS 67 0.61 54.69 7.53
28 INT118151 Positive_regulation of Prkcz 5 0.12 2.35 6.41
29 INT146594 Negative_regulation of Gene_expression of LEP 25 0.42 18.88 5.71
30 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65
31 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53
32 INT65356 Localization of LEP 46 0.79 41.17 5.43
33 INT91338 Binding of Lep 31 0.48 26.86 5.39
34 INT100222 Binding of Src 9 0.26 5.41 5.37
35 INT102935 Regulation of Lep 31 0.60 18.47 5.24
36 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95
37 INT100220 Negative_regulation of Src 13 0.41 6.37 4.93
38 INT240934 Gene_expression of Sirt1 24 0.75 18.77 4.68
39 INT98453 Positive_regulation of Src 19 0.47 7.84 4.62
40 INT97391 Binding of Lep 18 0.48 8.97 4.47
41 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
42 INT163581 Localization of Lep 27 0.79 18.99 4.08
43 INT89394 Phosphorylation of INS 37 0.82 35.84 3.9
44 INT25709 Negative_regulation of Igf2 11 0.56 9.38 3.76
45 INT119606 Regulation of Gene_expression of LEP 17 0.45 17.96 3.75
46 INT174054 Positive_regulation of Gene_expression of Lep 25 0.69 21.3 3.72
47 INT122327 Regulation of Src 6 0.59 0.59 3.6
48 INT82077 Positive_regulation of Gene_expression of Lep 32 0.70 17.9 3.5
49 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
50 INT137350 Phosphorylation of Src 13 0.45 4.14 3.32
51 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
52 INT38987 Protein_catabolism of INS 21 0.99 11.92 2.91
53 INT32623 Negative_regulation of Regulation of INS 16 0.43 10.96 2.9
54 INT118156 Binding of Prkcz 2 0.08 2.68 2.89
55 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
56 INT9335 Gene_expression of Igf2 18 0.72 12.76 2.78
57 INT97443 Positive_regulation of Positive_regulation of LEP 13 0.50 11.91 2.65
58 INT225253 Positive_regulation of Phosphorylation of Src 4 0.38 2.36 2.59
59 INT103487 Positive_regulation of Positive_regulation of Lep 9 0.67 4.08 2.38
60 INT9327 Localization of Igf2 8 0.80 5.07 2.36
61 INT25208 Gene_expression of IGF2 43 0.74 30.64 2.31
62 INT29402 Gene_expression of Src 16 0.74 4.57 2.29
63 INT3315 Negative_regulation of Positive_regulation of INS 31 0.57 14.73 2.27
64 INT57132 Positive_regulation of Igf2 9 0.50 5.15 2.22
65 INT26177 Regulation of Regulation of INS 19 0.44 11.32 2.18
66 INT82081 Regulation of Gene_expression of Lep 11 0.53 7.78 2.12
67 INT221409 Regulation of Sirt1 8 0.58 5.53 2.1
68 INT83392 Transcription of Lep 6 0.54 5.07 2.04
69 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
70 INT249530 Positive_regulation of Positive_regulation of Src 3 0.28 1.32 1.9
71 INT109059 Gene_expression of PRKCZ 2 0.65 0.64 1.87
72 INT3866 Positive_regulation of Positive_regulation of INS 30 0.59 21.58 1.86
73 INT82083 Negative_regulation of Gene_expression of Lep 12 0.56 8.07 1.75
74 INT146943 Gene_expression of Src 13 0.49 6.65 1.65
75 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
76 INT118149 Positive_regulation of Binding of Prkcz 1 0.09 0.58 1.54
77 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
78 INT255787 Positive_regulation of Gene_expression of Sirt1 9 0.67 7.61 1.5
79 INT98455 Regulation of Src 4 0.20 1.76 1.48
80 INT289575 Gene_expression of Sirt1 47 0.77 29.29 1.47
81 INT214115 Regulation of Gene_expression of Lep 9 0.61 7.37 1.44
82 INT118150 Positive_regulation of Positive_regulation of Prkcz 1 0.08 0.49 1.42
83 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
84 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
85 INT109104 Positive_regulation of Protein_catabolism of INS 4 0.50 4.44 1.24
86 INT175520 Gene_expression of Igf2 43 0.78 48.93 1.21
87 INT9324 Negative_regulation of Gene_expression of Igf2 6 0.50 5.12 1.2
88 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19
89 INT25710 Regulation of Igf2 6 0.62 3.1 1.17
90 INT3486 Positive_regulation of Regulation of INS 9 0.47 5.65 1.15
91 INT213465 Transcription of Lep 4 0.68 2.11 1.15
92 INT183046 Transcription of INS 25 0.70 11.14 1.13
93 INT253813 Regulation of Negative_regulation of Lep 2 0.45 1.01 1.12
94 INT249522 Positive_regulation of Binding of Src 1 0.22 0.68 1.12
95 INT82084 Positive_regulation of Localization of Lep 11 0.70 4.65 1.11
96 INT124167 Regulation of Positive_regulation of Src 2 0.13 0.47 1.1
97 INT92588 Positive_regulation of IGF2 8 0.58 4.2 1.07
98 INT289553 Positive_regulation of Gene_expression of Sirt1 21 0.69 20.43 1.03
99 INT168065 Binding of Sirt1 13 0.47 4.55 1.02
100 INT58470 Negative_regulation of Binding of INS 14 0.43 7.2 1.01
101 INT145864 Gene_expression of Irs1 5 0.71 3.34 1.01
102 INT317504 Protein_catabolism of Src 1 0.49 0.13 0.97
103 INT100221 Negative_regulation of Phosphorylation of Src 2 0.24 0.74 0.93
104 INT34779 Regulation of IGF2 7 0.38 4.34 0.9
105 INT167763 Negative_regulation of Prkcz 1 0.04 0.32 0.88
106 INT117308 Negative_regulation of Localization of Lep 3 0.59 2.16 0.86
107 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85
108 INT333883 Positive_regulation of Positive_regulation of Lep 2 0.46 1.06 0.83
109 INT109060 Regulation of Gene_expression of PRKCZ 1 0.03 0 0.83
110 INT167833 Positive_regulation of Ins2 4 0.50 6.52 0.82
111 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81
112 INT289550 Positive_regulation of Sirt1 25 0.69 13.59 0.8
113 INT143912 Localization of Src 4 0.48 2.51 0.78
114 INT58245 Regulation of Localization of Igf2 1 0.62 1.27 0.78
115 INT249506 Regulation of Phosphorylation of Src 1 0.13 0.48 0.77
116 INT12057 Regulation of Negative_regulation of INS 7 0.40 3.92 0.76
117 INT82080 Regulation of Localization of Lep 2 0.45 1.36 0.76
118 INT321433 Negative_regulation of IRS1 3 0.32 5.41 0.75
119 INT156533 Transcription of LEP 9 0.69 4.35 0.74
120 INT213471 Positive_regulation of Localization of Lep 4 0.48 2.65 0.74
121 INT280678 Transcription of Irs1 1 0.45 0.87 0.68
122 INT312830 Regulation of Ins2 2 0.39 1.45 0.66
123 INT242655 Binding of Irs1 1 0.29 1.45 0.66
124 INT183789 Positive_regulation of Phosphorylation of INS 5 0.50 4.87 0.64
125 INT14570 Regulation of Positive_regulation of INS 8 0.45 4.97 0.62
126 INT101484 Regulation of Positive_regulation of Lep 3 0.45 1.68 0.61
127 INT345957 Positive_regulation of Binding of Lep 2 0.38 2.03 0.6
128 INT83391 Negative_regulation of Transcription of Lep 1 0.43 0.34 0.6
129 INT284334 Gene_expression of IRS1 10 0.49 5.81 0.59
130 INT34778 Localization of IGF2 5 0.62 4.78 0.59
131 INT235996 Negative_regulation of Gene_expression of Src 3 0.09 1.29 0.58
132 INT306798 Protein_catabolism of LEP 1 0.65 2.45 0.58
133 INT115255 Negative_regulation of Phosphorylation of Irs1 6 0.45 3.71 0.56
134 INT143910 Negative_regulation of Positive_regulation of Src 1 0.27 0.14 0.56
135 INT277644 Negative_regulation of Localization of Igf2 1 0.02 0.69 0.56
136 INT246832 Positive_regulation of Irs1 16 0.69 7.33 0.55
137 INT14571 Regulation of Binding of INS 2 0.23 2.44 0.53
138 INT117998 Positive_regulation of Gene_expression of Src 4 0.36 1.45 0.51
139 INT321417 Positive_regulation of Negative_regulation of IRS1 1 0.12 3.82 0.51
140 INT158517 Regulation of Irs1 2 0.39 1.02 0.5
141 INT289580 Negative_regulation of Sirt1 23 0.58 9.03 0.48
142 INT82819 Negative_regulation of Negative_regulation of LEP 3 0.56 2.22 0.46
143 INT312821 Binding of Ins2 2 0.37 2.13 0.46
144 INT249504 Localization of Src 1 0.36 0.32 0.46
145 INT213286 Positive_regulation of Binding of INS 6 0.50 4.85 0.45
146 INT110477 Positive_regulation of Localization of PRKCZ 1 0.20 0.07 0.45
147 INT300291 Phosphorylation of Sirt1 1 0.77 6.07 0.45
148 INT53667 Gene_expression of Ins2 10 0.65 5.65 0.44
149 INT213272 Negative_regulation of Phosphorylation of INS 7 0.40 9.13 0.44
150 INT70893 Positive_regulation of Gene_expression of IGF2 5 0.67 6.13 0.44
151 INT110479 Localization of PRKCZ 1 0.35 0.07 0.43
152 INT98456 Negative_regulation of Src 17 0.42 8.3 0.42
153 INT246828 Binding of Irs1 9 0.37 2.68 0.42
154 INT235635 Negative_regulation of Phosphorylation of IRS1 7 0.37 3.78 0.42
155 INT102934 Positive_regulation of Regulation of Lep 2 0.50 0.55 0.42
156 INT240935 Transcription of Sirt1 2 0.68 0.42 0.42
157 INT340290 Regulation of Transcription of Sirt1 1 0.43 0.13 0.42
158 INT9328 Regulation of Gene_expression of Igf2 1 0.39 0.91 0.42
159 INT323765 Negative_regulation of Binding of Lep 1 0.37 0.91 0.42
160 INT187726 Positive_regulation of Localization of LEP 5 0.50 5.31 0.41
161 INT145861 Regulation of Gene_expression of Irs1 2 0.41 0.83 0.41
162 INT145863 Negative_regulation of Gene_expression of Irs1 3 0.45 1.51 0.4
163 INT312829 Positive_regulation of Positive_regulation of Ins2 1 0.50 1.73 0.4
164 INT199340 Localization of Igf2 4 0.75 4.47 0.39
165 INT14569 Positive_regulation of Negative_regulation of INS 4 0.36 3.52 0.37
166 INT110478 Regulation of PRKCZ 1 0.20 0.1 0.37
167 INT48617 Negative_regulation of IGF2 4 0.25 0.22 0.36
168 INT57131 Negative_regulation of Positive_regulation of Igf2 1 0.36 0.67 0.35
169 INT240914 Negative_regulation of Sirt1 9 0.46 3.16 0.34
170 INT183066 Positive_regulation of Transcription of INS 8 0.49 5.31 0.34
171 INT158521 Positive_regulation of Negative_regulation of Irs1 1 0.02 0.57 0.33
172 INT249533 Regulation of Localization of Src 1 0.22 0.22 0.32
173 INT289546 Negative_regulation of Gene_expression of Sirt1 5 0.42 3.1 0.31
174 INT303962 Phosphorylation of Lep 2 0.80 5.2 0.31
175 INT213467 Negative_regulation of Localization of Lep 2 0.40 1.11 0.31
176 INT204368 Gene_expression of SIRT1 17 0.76 4.48 0.3
177 INT199358 Negative_regulation of Gene_expression of Igf2 3 0.43 4.48 0.3
178 INT156534 Positive_regulation of Transcription of LEP 1 0.14 0.34 0.3
179 INT202435 Transcription of IGF2 3 0.58 2.44 0.29
180 INT9329 Transcription of Igf2 2 0.58 1.28 0.29
181 INT141781 Positive_regulation of Negative_regulation of LEP 1 0.46 0.37 0.29
182 INT207293 Negative_regulation of Negative_regulation of INS 12 0.49 6 0.26
183 INT240830 Positive_regulation of Protein_catabolism of Irs1 2 0.69 0.82 0.26
184 INT171374 Binding of Src 2 0.13 0.44 0.24
185 INT215027 Regulation of Localization of Igf2 1 0.07 1.71 0.24
186 INT150977 Regulation of Regulation of LEP 3 0.37 2.07 0.23
187 INT246817 Positive_regulation of Binding of Irs1 1 0.50 0.37 0.23
188 INT240818 Protein_catabolism of Irs1 3 0.98 1 0.22
189 INT142417 Positive_regulation of Transcription of Lep 2 0.52 2.63 0.22
190 INT89406 Negative_regulation of Positive_regulation of IRS1 1 0.22 0.93 0.22
191 INT289551 Regulation of Sirt1 8 0.61 4.46 0.2
192 INT312822 Regulation of Transcription of Ins2 1 0.45 0.71 0.18
193 INT312825 Transcription of Ins2 1 0.69 0.7 0.18
194 INT246824 Negative_regulation of Irs1 6 0.43 2.13 0.17
195 INT246620 Negative_regulation of Positive_regulation of Sirt1 2 0.39 1.9 0.17
196 INT163816 Phosphorylation of Lep 2 0.63 2.2 0.17
197 INT333880 Protein_catabolism of Lep 1 0.65 0.34 0.17
198 INT284323 Regulation of IRS1 2 0.45 1.6 0.16
199 INT157134 Regulation of Localization of LEP 1 0.09 0.5 0.16
200 INT333882 Regulation of Binding of Lep 1 0.45 0.07 0.16
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