GO:0046638

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Name positive regulation of alpha-beta T cell differentiation
Categary Process
Go Slim No
Go Link GO:0046638
Unique Molecular Interactions 115
Total Molecular Interactions 153
Total Single Events 1182
Pain Genes Associated 15

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for positive regulation of alpha-beta T cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported for positive regulation of alpha-beta T cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
2 INT253863 Binding of LBP and PNP 1 0.13 1.5 1.5
3 INT140985 Gli3 Regulation of Ihh 1 0.29 0.85 0.85
4 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84
5 INT314203 Nos2 Positive_regulation of Gli3 1 0.19 1.27 0.73
6 INT68561 Binding of Gli3 and Ust 1 0.01 0.68 0.68
7 INT149899 Ihh Positive_regulation of Mmp7 1 0.04 1.69 0.65
8 INT149894 Ihh Positive_regulation of Localization of Mmp14 1 0.04 2.06 0.47
9 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44
10 INT113040 IHH Regulation of Gene_expression of INS 1 0.12 0.37 0.37
11 INT279369 Binding of ADA and Ifx 1 0.29 0.27 0.35
12 INT149897 Ihh Positive_regulation of Mmp14 1 0.03 0.93 0.33
13 INT149896 Ihh Regulation of Gene_expression of Col1a1 1 0.06 0.89 0.33
14 INT149895 Ihh Regulation of Localization of Mmp7 1 0.03 0.98 0.33
15 INT149902 Ihh Positive_regulation of SGCG 1 0.45 0.76 0.32
16 INT149898 Ihh Regulation of Localization of Mmp14 1 0.03 1.29 0.27
17 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24
18 INT183247 ADA Negative_regulation of ADORA1 1 0.01 0 0.23
19 INT210798 Ihh Positive_regulation of Itgbl1 1 0.34 0 0.23
20 INT256629 Binding of Ptch1 and Shh 7 0.42 4.22 0.19
21 INT210795 Ihh Negative_regulation of Itgb1 1 0.30 0 0.17
22 INT210782 Ihh Negative_regulation of Itgbl1 1 0.31 0 0.16
23 INT210804 Ihh Negative_regulation of Timp4 1 0.32 0 0.16
24 INT302930 Binding of Pnp and Chrm2 1 0.00 0.64 0.15
25 INT278373 Myd88 Regulation of Phosphorylation of Syk 1 0.15 0.35 0.15
26 INT275451 Binding of ZAP70 and Syk 1 0.02 0.12 0.1
27 INT275450 Binding of STAM and Syk 1 0.00 0.12 0.1
28 INT165161 Ihh Positive_regulation of Sostdc1 1 0.58 0.07 0.09
29 INT165160 Regulation of Ihh Positive_regulation of Sostdc1 1 0.23 0.07 0.09
30 INT165158 Positive_regulation of Ihh Positive_regulation of Sostdc1 1 0.42 0.07 0.09
31 INT210788 Ihh Negative_regulation of Coro1a 1 0.02 0 0.08
32 INT270464 Binding of Shh and Smo 1 0.07 1.3 0.08
33 INT210790 Ihh Negative_regulation of Cdkn1c 1 0.30 0 0.08
34 INT290906 Shh Positive_regulation of Egfr 1 0.23 0 0.08
35 INT210787 Ihh Negative_regulation of Nr3c1 1 0.33 0 0.08
36 INT298349 HES3 Positive_regulation of Shh 1 0.12 0.14 0.07
37 INT290905 Gene_expression of Shh Positive_regulation of Gene_expression of Angpt1 1 0.14 0 0.06
38 INT213563 Binding of Ctnnd2 and Shh 1 0.27 0.09 0.04
39 INT270459 Binding of Shh and Gli1 1 0.02 0.65 0.04
40 INT352014 Shh Positive_regulation of Gene_expression of Pax1 1 0.29 0.07 0.03
41 INT311655 Shh Positive_regulation of Gene_expression of Fgf8 1 0.31 0.18 0.03
42 INT270462 Shh Positive_regulation of Ccnd1 1 0.10 0.6 0.03
43 INT213559 Binding of Egf and Shh 1 0.17 0.07 0.03
44 INT278404 Syk Positive_regulation of Mapk1 1 0.13 0 0
45 INT320351 Pnp Regulation of Ighg2b 1 0.02 0.31 0
46 INT290910 Pkm2 Negative_regulation of Shh 1 0.07 0.06 0
47 INT205963 GLI1 Positive_regulation of Negative_regulation of SHH 1 0.22 0.58 0
48 INT314850 Shh Regulation of Atoh7 1 0.45 0.22 0
49 INT158907 Ogt Negative_regulation of Gene_expression of Ada 1 0.44 0 0
50 INT290908 Regulation of Shh Positive_regulation of Ntn1 1 0.12 0 0
51 INT86001 Binding of Pnp and Alms1 1 0.03 0 0
52 INT278400 Negative_regulation of Syk Negative_regulation of Positive_regulation of Hps5 1 0.16 0 0
53 INT278382 Binding of Syk and Nlrp3 1 0.24 0 0
54 INT290911 Gene_expression of Shh Positive_regulation of Pkm2 1 0.07 0 0
55 INT290904 Shh Positive_regulation of Prkcg 1 0.26 0.06 0
56 INT290900 Prkcg Regulation of Shh 1 0.23 0 0
57 INT278401 Syk Regulation of Positive_regulation of Hps5 1 0.19 0 0
58 INT197794 Negative_regulation of Pthlh Regulation of Ihh 1 0.36 1.33 0
59 INT320352 Pnp Positive_regulation of Ighg2b 1 0.03 0.08 0
60 INT278410 Gopc Positive_regulation of Phosphorylation of Syk 1 0.10 0.23 0
61 INT205960 Binding of PTCH1 and SHH 1 0.21 0.71 0
62 INT290944 Shh Positive_regulation of VEGFA 1 0.04 0.05 0
63 INT270461 Shh Regulation of Gene_expression of Ptch1 1 0.48 0.07 0
64 INT302926 Binding of Pnp and Pbrm1 1 0.01 0.96 0
65 INT278387 Syk Regulation of Positive_regulation of Il1 1 0.06 0 0
66 INT278372 Binding of Syk and Pycard 1 0.06 0 0
67 INT205959 Binding of SHH and SMOX 1 0.12 0.72 0
68 INT104529 Ada Negative_regulation of Positive_regulation of FSCN1 1 0.03 0 0
69 INT278399 Syk Positive_regulation of Localization of Ctsb 1 0.09 0.28 0
70 INT232056 Binding of DDR1 and PNP 1 0.01 0.55 0
71 INT270471 Shh Regulation of VEGFA 1 0.39 0.08 0
72 INT189110 Binding of Pnp and Asprv1 1 0.00 0 0
73 INT290898 Shh Positive_regulation of Nos2 1 0.46 0.05 0
74 INT104530 Ada Negative_regulation of FSCN1 1 0.03 0 0
75 INT302929 Binding of Pnp and Spna1 1 0.00 0.35 0
76 INT270466 Ptch1 Regulation of Gene_expression of Shh 1 0.48 0.07 0
77 INT312950 Binding of ADA and HBN1 1 0.01 0.49 0
78 INT278405 Tlr4 Positive_regulation of Syk 1 0.06 0 0
79 INT270460 Shh Positive_regulation of Gene_expression of Angpt1 1 0.04 0.08 0
80 INT209444 Stam Positive_regulation of Syk 1 0.01 0.26 0
81 INT270470 Shh Regulation of Gene_expression of VEGFA 1 0.39 0.15 0
82 INT278392 Syk Regulation of Positive_regulation of Ctsb 1 0.06 0 0
83 INT290907 Shh Positive_regulation of Ntn1 1 0.32 0.05 0
84 INT205977 Binding of SHH and Ptch1 1 0.31 0.71 0
85 INT270469 Shh Positive_regulation of VEGFA 1 0.29 0.12 0
86 INT278396 Msu Positive_regulation of Phosphorylation of Syk 1 0.25 0.27 0
87 INT154173 Binding of SIPA1 and SYK 1 0.16 0.46 0
88 INT270468 Shh Positive_regulation of Gene_expression of VEGFA 1 0.44 0.08 0
89 INT158906 Ogt Negative_regulation of Ada 1 0.33 0 0
90 INT264737 Hes1 Regulation of Shh 1 0.19 0.13 0
91 INT278380 Syk Positive_regulation of Pik3r1 1 0.13 0 0
92 INT197793 Pthlh Regulation of Ihh 1 0.22 1.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for positive regulation of alpha-beta T cell differentiation. They are ordered first by their pain relevance and then by number of times they were reported in positive regulation of alpha-beta T cell differentiation. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT32802 Negative_regulation of Ada 21 0.57 4.03 14.87
2 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98
3 INT4663 Positive_regulation of Ada 17 0.69 9.48 7.93
4 INT253864 Negative_regulation of PNP 13 0.26 6.84 6.67
5 INT29674 Gene_expression of Ada 16 0.78 4.59 5.69
6 INT30206 Negative_regulation of ADA 17 0.59 10.03 5.63
7 INT68202 Gene_expression of ADA 26 0.68 23.15 5.18
8 INT36256 Regulation of Ada 9 0.62 4.99 5.07
9 INT9767 Negative_regulation of Ada 5 0.55 0.06 5.06
10 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93
11 INT134590 Localization of ADA 7 0.65 8.43 3.96
12 INT72798 Binding of ADA 12 0.47 7.84 3.39
13 INT174232 Gene_expression of PNP 36 0.30 8.74 3.17
14 INT19392 Gene_expression of Ada 9 0.77 7.4 3.17
15 INT34604 Binding of Ada 11 0.31 4.15 3.1
16 INT9766 Positive_regulation of Ada 2 0.47 0.4 3.09
17 INT131494 Regulation of ADA 8 0.52 7.37 2.97
18 INT113041 Gene_expression of IHH 9 0.78 5.83 2.87
19 INT126581 Positive_regulation of Gli3 6 0.35 1.59 2.48
20 INT44979 Positive_regulation of Pnp 11 0.59 5.61 2.41
21 INT81312 Positive_regulation of Gene_expression of Ada 2 0.50 1.58 2.26
22 INT278340 Gene_expression of Syk 7 0.51 4.92 2.09
23 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02
24 INT144973 Gene_expression of Shh 9 0.77 4.32 1.96
25 INT61806 Regulation of Negative_regulation of Ada 1 0.30 0.63 1.89
26 INT40322 Binding of Pnp 12 0.38 11.13 1.78
27 INT208561 Gene_expression of Shh 51 0.78 9.57 1.77
28 INT34605 Localization of Ada 7 0.80 0.13 1.61
29 INT137927 Positive_regulation of Positive_regulation of Ada 1 0.03 1.31 1.47
30 INT140245 Binding of Gli3 3 0.36 2.65 1.46
31 INT30277 Protein_catabolism of Ada 3 0.52 0.9 1.42
32 INT181873 Regulation of Localization of ADA 1 0.07 1.98 1.41
33 INT140983 Gene_expression of Ihh 7 0.78 2.06 1.15
34 INT253191 Positive_regulation of Gene_expression of Shh 2 0.66 2.57 1.14
35 INT192073 Positive_regulation of Gene_expression of ADA 8 0.47 10.35 1.12
36 INT238636 Regulation of Ada 2 0.15 1.12 1.06
37 INT165530 Positive_regulation of Shh 4 0.69 1.21 1.05
38 INT275940 Negative_regulation of Syk 3 0.39 2.08 0.95
39 INT238637 Binding of Ada 2 0.26 1.01 0.94
40 INT126572 Positive_regulation of SYK 3 0.67 2.98 0.83
41 INT68200 Protein_catabolism of Ada 2 0.44 0.68 0.83
42 INT108044 Phosphorylation of Syk 3 0.25 1.39 0.77
43 INT279366 Positive_regulation of Localization of ADA 2 0.42 4.37 0.76
44 INT40605 Negative_regulation of Negative_regulation of Ada 1 0.32 0 0.7
45 INT68560 Regulation of Gli3 3 0.18 1.51 0.68
46 INT50440 Negative_regulation of Pnp 5 0.36 2.14 0.66
47 INT210028 Protein_catabolism of ADA 1 0.07 0.13 0.62
48 INT113042 Localization of IHH 1 0.70 0.77 0.61
49 INT132324 Localization of SYK 2 0.78 1.9 0.59
50 INT278152 Negative_regulation of Syk 1 0.24 1.93 0.59
51 INT140984 Regulation of Ihh 5 0.54 2.81 0.56
52 INT132325 Positive_regulation of Localization of SYK 1 0.49 0.56 0.54
53 INT135062 Transcription of Gli3 1 0.05 0 0.52
54 INT154180 Negative_regulation of SYK 3 0.43 4.67 0.5
55 INT302775 Negative_regulation of Gene_expression of Syk 1 0.27 0.84 0.48
56 INT206484 Localization of Shh 2 0.75 1.14 0.46
57 INT232798 Positive_regulation of Gene_expression of Shh 7 0.70 1.49 0.44
58 INT143682 Negative_regulation of Gene_expression of Ada 2 0.54 0.28 0.44
59 INT143683 Negative_regulation of Gene_expression of ADA 1 0.09 0.28 0.44
60 INT154182 Phosphorylation of SYK 6 0.82 5.54 0.43
61 INT56363 Regulation of Gene_expression of Ada 1 0.06 0.59 0.42
62 INT208559 Negative_regulation of Gene_expression of Shh 8 0.43 1.58 0.38
63 INT154181 Positive_regulation of Phosphorylation of SYK 4 0.70 4.71 0.37
64 INT154175 Regulation of SYK 2 0.62 1.48 0.34
65 INT166716 Negative_regulation of Ihh 3 0.43 0.67 0.33
66 INT279365 Regulation of Regulation of ADA 1 0.23 0 0.33
67 INT108043 Negative_regulation of Phosphorylation of Syk 1 0.13 0.53 0.31
68 INT154559 Positive_regulation of Syk 2 0.20 0.74 0.3
69 INT232795 Positive_regulation of Shh 2 0.70 3.68 0.26
70 INT149893 Positive_regulation of Gene_expression of Ihh 1 0.69 0.62 0.26
71 INT278155 Regulation of Negative_regulation of Syk 1 0.18 0.55 0.26
72 INT149892 Gene_expression of Ihh 1 0.77 0.61 0.26
73 INT135061 Protein_catabolism of Gli3 1 0.04 0 0.25
74 INT252723 Gene_expression of SYK 3 0.25 2.67 0.23
75 INT278154 Regulation of Syk 1 0.05 0.98 0.22
76 INT278147 Localization of Syk 1 0.30 0.98 0.22
77 INT169061 Gene_expression of Pnp 19 0.66 9.39 0.21
78 INT183062 Gene_expression of SHH 12 0.65 5.28 0.21
79 INT169062 Positive_regulation of Gene_expression of Pnp 6 0.49 3.6 0.21
80 INT134477 Negative_regulation of SHH 2 0.37 1.13 0.2
81 INT149888 Localization of Ihh 1 0.75 0.77 0.2
82 INT135060 Negative_regulation of Transcription of Gli3 1 0.03 0 0.19
83 INT232799 Regulation of Gene_expression of Shh 3 0.27 1.04 0.16
84 INT253177 Negative_regulation of Gene_expression of Shh 2 0.55 0.63 0.16
85 INT275937 Phosphorylation of Syk 3 0.54 1.67 0.15
86 INT278241 Regulation of IHH 2 0.31 1.16 0.14
87 INT154177 Negative_regulation of Phosphorylation of SYK 1 0.43 1.51 0.14
88 INT253190 Localization of Shh 2 0.77 1.06 0.13
89 INT253183 Negative_regulation of Shh 8 0.55 2.13 0.12
90 INT270451 Localization of Gli3 1 0.26 0.63 0.11
91 INT323226 Negative_regulation of Localization of ADA 1 0.35 3.05 0.1
92 INT275411 Binding of Syk 1 0.09 0.12 0.1
93 INT110170 Positive_regulation of Positive_regulation of ADA 1 0.49 0.46 0.1
94 INT270442 Transcription of Shh 1 0.53 0.25 0.09
95 INT135063 Regulation of Gene_expression of Gli3 1 0.04 0 0.09
96 INT213515 Binding of Shh 8 0.37 1.92 0.08
97 INT169060 Negative_regulation of Gene_expression of Pnp 3 0.42 0.95 0.08
98 INT210805 Negative_regulation of IHH 2 0.42 0.74 0.08
99 INT270453 Regulation of Shh 1 0.27 0.83 0.08
100 INT211097 Negative_regulation of Binding of Pnp 1 0.08 1.27 0.08
101 INT126375 Negative_regulation of Gene_expression of Gli3 1 0.58 0.79 0.08
102 INT205973 Binding of SHH 3 0.35 1.03 0.07
103 INT199076 Positive_regulation of Syk 3 0.31 0.12 0.07
104 INT168919 Regulation of Regulation of Ihh 1 0.40 0.43 0.07
105 INT256862 Regulation of Shh 1 0.25 0 0.07
106 INT270445 Positive_regulation of Localization of Shh 1 0.44 0.13 0.05
107 INT251811 Positive_regulation of IHH 1 0.29 0.09 0.05
108 INT218757 Regulation of Pnp 4 0.15 5.51 0.04
109 INT181793 Positive_regulation of SHH 3 0.67 2.59 0.04
110 INT208560 Negative_regulation of Shh 2 0.59 2.22 0.04
111 INT278363 Binding of Syk 1 0.32 0.3 0.04
112 INT276348 Positive_regulation of Positive_regulation of SYK 1 0.22 0.66 0.04
113 INT165149 Positive_regulation of Ihh 1 0.42 0.09 0.04
114 INT276371 Positive_regulation of Gene_expression of SYK 1 0.22 0.67 0.03
115 INT253187 Negative_regulation of Transcription of Shh 1 0.41 0.55 0.03
116 INT253181 Transcription of Shh 1 0.68 0.54 0.03
117 INT294470 Transcription of IHH 1 0.16 0.28 0.03
118 INT232066 Binding of PNP 3 0.13 0.28 0
119 INT232073 Regulation of PNP 2 0.12 0.33 0
120 INT174238 Positive_regulation of Gene_expression of PNP 2 0.16 0.69 0
121 INT280520 Regulation of Gene_expression of Pnp 1 0.15 0.55 0
122 INT154178 Binding of SYK 1 0.37 0.46 0
123 INT278354 Positive_regulation of Phosphorylation of Syk 1 0.31 0.23 0
124 INT275951 Negative_regulation of Phosphorylation of Syk 1 0.34 0.2 0
125 INT322888 Negative_regulation of Ihh 1 0.26 0.45 0
126 INT285458 Negative_regulation of Gene_expression of PNP 1 0.11 0 0
127 INT285456 Positive_regulation of PNP 1 0.13 0.08 0
128 INT278348 Positive_regulation of Gene_expression of Syk 1 0.33 0 0
129 INT278326 Regulation of Positive_regulation of Syk 1 0.18 0 0
130 INT285457 Localization of PNP 1 0.21 0 0
131 INT320332 Transcription of Pnp 1 0.05 0.05 0
132 INT290918 Negative_regulation of Positive_regulation of Shh 1 0.41 0.25 0
133 INT194939 Regulation of Phosphorylation of SYK 1 0.18 0.31 0
134 INT302919 Negative_regulation of Regulation of Pnp 1 0.04 1.71 0
135 INT230972 Positive_regulation of Gene_expression of SHH 1 0.18 0.07 0
136 INT290929 Binding of Shh 1 0.31 0.1 0
137 INT278346 Positive_regulation of Negative_regulation of Syk 1 0.33 0 0
138 INT290927 Regulation of Positive_regulation of Shh 1 0.23 0 0
139 INT301356 Binding of Ihh 1 0.08 0.06 0
140 INT270449 Negative_regulation of Positive_regulation of Shh 1 0.43 0.24 0
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