GO:0046653

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Name tetrahydrofolate metabolic process
Categary Process
Go Slim No
Go Link GO:0046653
Unique Molecular Interactions 59
Total Molecular Interactions 78
Total Single Events 558
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for tetrahydrofolate metabolic process. They are ordered first by their pain relevance and then by number of times they were reported for tetrahydrofolate metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
2 INT158762 Binding of Vwf and Mthfr 1 0.05 1.85 1.37
3 INT27425 Mtr Positive_regulation of Gene_expression of Il1f5 1 0.06 0 1.3
4 INT45891 Tyms Positive_regulation of Localization of Acot1 1 0.02 0 1.23
5 INT35399 Binding of Alox5 and Mthfs 1 0.01 0 1.14
6 INT68164 Mthfs Positive_regulation of Positive_regulation of Alox5 1 0.00 0.64 1.13
7 INT68167 Alox5 Positive_regulation of Positive_regulation of Mthfs 1 0.00 0.64 1.13
8 INT68154 Mthfs Positive_regulation of Pdpk1 1 0.01 0.63 1.12
9 INT68161 Mthfs Positive_regulation of Positive_regulation of Pla2g1b 1 0.03 0.64 1.12
10 INT68155 Pla2g1b Positive_regulation of Positive_regulation of Mthfs 1 0.03 0.64 1.12
11 INT68163 Mthfs Positive_regulation of Positive_regulation of Pdpk1 1 0.01 0.64 1.12
12 INT107561 Mtr Positive_regulation of Localization of Il1b 1 0.04 0.09 1.09
13 INT107563 Penk Regulation of Mtr 1 0.00 0.1 1.04
14 INT107565 Hps4 Regulation of Mtr 1 0.00 0.1 1.04
15 INT323278 Dhfr Negative_regulation of Negative_regulation of Igkv1-131 1 0.02 0.93 1.02
16 INT25110 RYBP Negative_regulation of MTHFS 1 0.02 0 0.92
17 INT91273 Mtr Positive_regulation of Localization of Il6 1 0.17 0 0.88
18 INT54669 Mtr Regulation of Gene_expression of Il1 1 0.02 0.2 0.77
19 INT54668 Mtr Regulation of Gene_expression of Il1f5 1 0.00 0.2 0.76
20 INT46657 Mtr Regulation of Gnrh1 1 0.01 0 0.71
21 INT46656 Mtr Regulation of Prl 1 0.05 0 0.7
22 INT38820 Binding of MTR and PDYN 1 0.03 0.19 0.65
23 INT27426 Mtr Positive_regulation of Localization of Il1f5 1 0.06 0 0.63
24 INT127778 Mthfd1 Regulation of Positive_regulation of Mthfr 1 0.01 0.71 0.62
25 INT35397 Fnd3c2 Negative_regulation of Binding of Mthfs 1 0.00 0 0.58
26 INT50935 Mtr Regulation of Gene_expression of Il6 1 0.00 0 0.53
27 INT323280 Dhfr Negative_regulation of Igkv1-131 1 0.02 0.47 0.51
28 INT177782 PDCD2 Positive_regulation of MTHFD2 1 0.06 0.76 0.46
29 INT177787 BUB1B Positive_regulation of MTHFD2 1 0.15 0.76 0.46
30 INT28863 Mtr Negative_regulation of Dhfr 1 0.04 0.87 0.45
31 INT28864 Mtx1 Negative_regulation of Dhfr 1 0.19 0.87 0.44
32 INT141848 Mthfs Negative_regulation of Cpox 1 0.01 0 0.34
33 INT188789 Binding of pad and Mthfr 1 0.06 4.6 0.31
34 INT55903 Negative_regulation of Mthfs Negative_regulation of Localization of Ptafr 1 0.01 0.35 0.24
35 INT143628 MTHFS Positive_regulation of Gene_expression of MRXS5 1 0.01 0.55 0.23
36 INT50934 Mtr Positive_regulation of Gene_expression of Il6 1 0.00 0 0.2
37 INT236405 Mthfs Regulation of Gene_expression of VEGFA 1 0.00 0.25 0.2
38 INT44977 Negative_regulation of Mthfs Negative_regulation of Gfra1 1 0.00 0.2 0.15
39 INT236404 Binding of VEGFA and Mthfs 1 0.00 0.3 0.14
40 INT54131 Binding of Cbr1 and Mthfs 1 0.01 0.25 0.12
41 INT236401 Binding of Flt1 and Mthfs 1 0.01 0.28 0.11
42 INT236406 Mthfs Negative_regulation of Gene_expression of VEGFA 1 0.00 0.3 0.11
43 INT245985 Binding of MTR and Mtrr 1 0.06 0.8 0.07
44 INT245986 MTR Regulation of Mthfr 1 0.07 0.18 0.05
45 INT245981 Negative_regulation of TCN1 Regulation of Mthfr 1 0.03 0.18 0.05
46 INT245966 TCN1 Regulation of MTR 1 0.02 0.18 0.05
47 INT245982 TCN1 Regulation of Mthfr 1 0.04 0.18 0.05
48 INT245967 Negative_regulation of TCN1 Regulation of MTR 1 0.02 0.18 0.05
49 INT245974 Mtrr Regulation of Mthfr 1 0.07 0.18 0.05
50 INT245987 Binding of MTR and Mthfr 1 0.11 0.48 0.03
51 INT234144 Fig4 Negative_regulation of Transcription of Tyms 1 0.05 0.18 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for tetrahydrofolate metabolic process. They are ordered first by their pain relevance and then by number of times they were reported in tetrahydrofolate metabolic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT5069 Negative_regulation of Mthfs 69 0.57 22.54 31.36
2 INT5298 Negative_regulation of MTHFS 70 0.57 27.07 28.11
3 INT1672 Gene_expression of Mtr 18 0.67 3.39 13.32
4 INT20131 Negative_regulation of Mthfs 18 0.57 7.93 10.54
5 INT9802 Positive_regulation of Mtr 9 0.60 3.69 7.43
6 INT46518 Localization of Mtr 12 0.65 1.31 6.55
7 INT10006 Regulation of Mtr 9 0.23 3.56 5.42
8 INT12250 Negative_regulation of Mtr 19 0.50 6.9 5.35
9 INT121954 Binding of Mthfr 17 0.44 13.47 4.66
10 INT44805 Positive_regulation of Mthfs 9 0.49 2.32 4.48
11 INT9803 Positive_regulation of Gene_expression of Mtr 3 0.60 1.45 4.36
12 INT17444 Gene_expression of MTHFS 14 0.66 5.17 3.85
13 INT24751 Gene_expression of Mtr 8 0.36 1.34 3.34
14 INT138652 Negative_regulation of Mthfr 13 0.54 7.3 2.88
15 INT25128 Gene_expression of Mthfs 9 0.25 2.38 2.75
16 INT52911 Gene_expression of Tyms 10 0.42 2.24 2.66
17 INT3123 Localization of Tyms 6 0.78 0.85 2.6
18 INT124417 Gene_expression of Mthfr 8 0.60 8.65 2.53
19 INT127777 Positive_regulation of Mthfr 4 0.38 3.8 2.09
20 INT142049 Regulation of Mthfr 6 0.41 4.73 2
21 INT25582 Regulation of Mtr 2 0.03 0.4 1.76
22 INT5068 Binding of Mthfs 4 0.44 1.26 1.7
23 INT29836 Regulation of MTHFS 6 0.33 1.43 1.67
24 INT25131 Localization of Mthfs 5 0.34 2.09 1.63
25 INT12290 Gene_expression of Dhfr 7 0.76 2.04 1.47
26 INT47446 Regulation of Localization of Mtr 1 0.05 0.07 1.42
27 INT10032 Localization of MTHFS 4 0.17 3.11 1.37
28 INT9217 Negative_regulation of MTR 17 0.58 1.13 1.32
29 INT2595 Binding of Mtr 1 0.29 0 1.24
30 INT52912 Binding of Tyms 5 0.46 0.78 1.16
31 INT47131 Negative_regulation of Localization of Mtr 1 0.41 0 1.06
32 INT157361 Localization of MTR 2 0.31 1.4 1.05
33 INT24750 Negative_regulation of Mtr 1 0.22 0.06 1.04
34 INT35396 Binding of Mthfs 3 0.07 1.1 1.02
35 INT45917 Regulation of Negative_regulation of MTHFS 1 0.44 0 1.02
36 INT103240 Negative_regulation of Tyms 4 0.57 1.7 0.99
37 INT39330 Negative_regulation of Negative_regulation of Mthfs 2 0.26 0.82 0.96
38 INT34923 Positive_regulation of MTHFS 2 0.49 1.4 0.9
39 INT34863 Positive_regulation of Negative_regulation of MTHFS 1 0.49 1.02 0.86
40 INT5067 Negative_regulation of Binding of Mthfs 1 0.41 0.26 0.81
41 INT64221 Positive_regulation of Gene_expression of Mthfs 2 0.07 0.44 0.77
42 INT22378 Negative_regulation of Negative_regulation of MTHFS 3 0.57 0.18 0.74
43 INT24584 Positive_regulation of MTR 4 0.44 0.07 0.7
44 INT113192 Positive_regulation of Positive_regulation of Mthfs 1 0.07 0.45 0.68
45 INT155639 Regulation of Negative_regulation of Mthfr 1 0.56 0.76 0.66
46 INT285339 Negative_regulation of Gene_expression of Dhfr 1 0.11 1.93 0.65
47 INT285337 Regulation of Gene_expression of Dhfr 1 0.11 1.93 0.65
48 INT127776 Regulation of Mthfd1 1 0.20 0.65 0.64
49 INT10007 Regulation of Gene_expression of Mtr 2 0.23 1.17 0.61
50 INT34861 Regulation of Localization of Mthfs 1 0.23 0.38 0.61
51 INT14109 Positive_regulation of Mtr 1 0.03 0.49 0.6
52 INT42082 Regulation of Mthfs 3 0.44 0.57 0.58
53 INT45854 Positive_regulation of Negative_regulation of Mthfs 2 0.45 0.83 0.53
54 INT323258 Positive_regulation of Dhfr 1 0.20 0.66 0.49
55 INT177878 Positive_regulation of Gene_expression of MTHFD2 1 0.26 1.16 0.46
56 INT177882 Gene_expression of MTHFD2 1 0.40 1.16 0.46
57 INT45855 Regulation of Negative_regulation of Mthfs 2 0.44 0.23 0.44
58 INT97316 Positive_regulation of Gene_expression of Mthfs 1 0.04 0 0.43
59 INT97317 Gene_expression of Mthfs 1 0.06 0 0.42
60 INT24583 Protein_catabolism of MTR 1 0.57 0 0.42
61 INT44273 Binding of MTHFS 3 0.29 0.81 0.41
62 INT188788 Negative_regulation of Gene_expression of Mthfr 2 0.33 1.3 0.39
63 INT54952 Binding of Mtr 1 0.03 0.58 0.37
64 INT25129 Negative_regulation of Localization of Mthfs 2 0.16 0.5 0.35
65 INT25132 Negative_regulation of Gene_expression of Mthfs 2 0.08 0.39 0.33
66 INT26194 Regulation of MTR 1 0.19 1.1 0.33
67 INT166893 Negative_regulation of Gene_expression of Mtr 1 0.03 0.57 0.33
68 INT105447 Positive_regulation of Gene_expression of MTHFS 2 0.32 0.78 0.31
69 INT282213 Negative_regulation of Regulation of Mtr 1 0.01 0.82 0.27
70 INT44275 Negative_regulation of Positive_regulation of MTHFS 1 0.25 0.15 0.25
71 INT67859 Negative_regulation of Gene_expression of MTHFS 1 0.07 0.33 0.24
72 INT70913 Gene_expression of MTR 2 0.12 0.44 0.21
73 INT138653 Positive_regulation of Negative_regulation of Mthfr 1 0.45 0.53 0.2
74 INT44276 Negative_regulation of Regulation of MTHFS 1 0.16 0.08 0.18
75 INT241468 Binding of Dhfr 2 0.13 1.41 0.17
76 INT106988 Negative_regulation of Binding of Mthfs 1 0.04 0.25 0.17
77 INT57182 Negative_regulation of Dhfr 2 0.55 0.37 0.16
78 INT223333 Negative_regulation of Gene_expression of MTR 1 0.07 0.16 0.16
79 INT55773 Binding of MTR 2 0.30 0.74 0.14
80 INT113808 Positive_regulation of Mthfs 1 0.01 0.81 0.12
81 INT122581 Negative_regulation of Positive_regulation of Mthfs 1 0.02 0.07 0.1
82 INT12251 Regulation of Negative_regulation of Mtr 1 0.19 0 0.09
83 INT106363 Positive_regulation of Tyms 2 0.02 0.66 0.08
84 INT162255 Positive_regulation of Binding of Tyms 2 0.45 0.64 0.07
85 INT55772 Negative_regulation of Negative_regulation of MTR 1 0.41 0 0.07
86 INT234136 Transcription of Tyms 1 0.48 0.77 0.06
87 INT234129 Positive_regulation of Transcription of Tyms 1 0.35 0.12 0.06
88 INT288754 Negative_regulation of Positive_regulation of Mtr 1 0.11 0.1 0.05
89 INT77507 Regulation of Mthfs 1 0.03 0.71 0.05
90 INT143346 Localization of Mthfr 2 0.54 0.4 0.04
91 INT288765 Positive_regulation of Negative_regulation of Mtr 1 0.12 0.09 0.04
92 INT106364 Positive_regulation of Gene_expression of Tyms 2 0.01 0.65 0
93 INT234130 Negative_regulation of Transcription of Tyms 1 0.30 0.13 0
94 INT142048 Transcription of Mthfr 1 0.51 0.18 0
95 INT47058 Positive_regulation of Negative_regulation of MTR 1 0.41 0 0
96 INT47059 Positive_regulation of Positive_regulation of MTR 1 0.44 0 0
97 INT177852 Negative_regulation of Gene_expression of MTHFD2 1 0.22 0.4 0
98 INT299472 Positive_regulation of Gene_expression of Dhfr 1 0.20 0 0
99 INT234132 Regulation of Transcription of Tyms 1 0.19 0.16 0
100 INT234137 Regulation of Gene_expression of Tyms 1 0.19 0.16 0
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