GO:0046654

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Name tetrahydrofolate biosynthetic process
Categary Process
Go Slim No
Go Link GO:0046654
Unique Molecular Interactions 12
Total Molecular Interactions 45
Total Single Events 106
Pain Genes Associated 5

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for tetrahydrofolate biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported for tetrahydrofolate biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6
2 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67
3 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65
4 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54
5 INT135830 Gch1 Regulation of Nos2 1 0.65 0 1.29
6 INT323278 Dhfr Negative_regulation of Negative_regulation of Igkv1-131 1 0.02 0.93 1.02
7 INT239500 Binding of Aes and Atic 1 0.20 0.4 0.56
8 INT323280 Dhfr Negative_regulation of Igkv1-131 1 0.02 0.47 0.51
9 INT28863 Mtr Negative_regulation of Dhfr 1 0.04 0.87 0.45
10 INT28864 Mtx1 Negative_regulation of Dhfr 1 0.19 0.87 0.44
11 INT241459 Gart Positive_regulation of Racgap1 1 0.01 0 0.03
12 INT229884 Gart Regulation of AKT1 1 0.02 0.4 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for tetrahydrofolate biosynthetic process. They are ordered first by their pain relevance and then by number of times they were reported in tetrahydrofolate biosynthetic process. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53
2 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14
3 INT152347 Binding of GCH1 8 0.37 6.13 7.36
4 INT163776 Regulation of GCH1 7 0.27 4.58 6.16
5 INT135815 Transcription of Gch1 1 0.60 0 3.32
6 INT150933 Negative_regulation of Positive_regulation of GCH1 3 0.58 1.8 2.77
7 INT150932 Positive_regulation of Gene_expression of GCH1 3 0.70 2.07 2.57
8 INT283973 Transcription of GCH1 1 0.61 1.99 2.33
9 INT283975 Negative_regulation of Localization of GCH1 1 0.38 1.99 2.27
10 INT135827 Positive_regulation of Transcription of Gch1 1 0.58 0 2.2
11 INT258637 Regulation of Gene_expression of GCH1 1 0.62 1.77 2.02
12 INT135820 Regulation of Gch1 1 0.59 0 1.88
13 INT12290 Gene_expression of Dhfr 7 0.76 2.04 1.47
14 INT135822 Gene_expression of Gch1 2 0.50 0.77 1.35
15 INT122891 Negative_regulation of Gch1 4 0.16 1.83 1.15
16 INT283974 Negative_regulation of Transcription of GCH1 1 0.38 0.99 1.13
17 INT283972 Localization of GCH1 1 0.67 0.99 1.13
18 INT283976 Positive_regulation of Binding of GCH1 1 0.45 1.27 1.13
19 INT150931 Negative_regulation of GCH1 6 0.59 1.23 1.05
20 INT285339 Negative_regulation of Gene_expression of Dhfr 1 0.11 1.93 0.65
21 INT285337 Regulation of Gene_expression of Dhfr 1 0.11 1.93 0.65
22 INT323258 Positive_regulation of Dhfr 1 0.20 0.66 0.49
23 INT325209 Localization of Gch1 1 0.25 0.72 0.28
24 INT325214 Positive_regulation of Localization of Gch1 1 0.17 0.73 0.28
25 INT325216 Positive_regulation of Gch1 2 0.23 1.5 0.27
26 INT325218 Negative_regulation of Positive_regulation of Gch1 2 0.14 1.51 0.27
27 INT325205 Positive_regulation of Gene_expression of Gch1 1 0.17 0.77 0.19
28 INT241468 Binding of Dhfr 2 0.13 1.41 0.17
29 INT57182 Negative_regulation of Dhfr 2 0.55 0.37 0.16
30 INT350591 Positive_regulation of Gart 1 0.11 0.96 0.1
31 INT229871 Binding of Gart 1 0.05 0.43 0.03
32 INT299472 Positive_regulation of Gene_expression of Dhfr 1 0.20 0 0
33 INT163775 Negative_regulation of Regulation of GCH1 1 0.43 0 0
34 INT350587 Negative_regulation of Gart 1 0.09 0.67 0
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