GO:0046676

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Name negative regulation of insulin secretion
Categary Process
Go Slim No
Go Link GO:0046676
Unique Molecular Interactions 635
Total Molecular Interactions 994
Total Single Events 6643
Pain Genes Associated 37

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for negative regulation of insulin secretion. They are ordered first by their pain relevance and then by number of times they were reported for negative regulation of insulin secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
2 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
3 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
4 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
5 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
6 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
7 INT226118 Ghrl Regulation of Prkag1 1 0.08 0.72 2.72
8 INT25708 Oprl1 Positive_regulation of Adra2a 1 0.25 0.15 2.63
9 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
10 INT146587 Npff Negative_regulation of Positive_regulation of Casp3 1 0.05 0.18 1.92
11 INT146586 Npff Negative_regulation of Gene_expression of Casp3 1 0.06 0.18 1.92
12 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
13 INT18786 Binding of Adra2a and Nisch 2 0.19 0 1.7
14 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
15 INT353717 Binding of Ghrl and Vta1 1 0.15 0 1.68
16 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66
17 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
18 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
19 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
20 INT19013 Ghsr Negative_regulation of Localization of Sst 1 0.15 0 1.44
21 INT19012 Ghsr Negative_regulation of Localization of Sstr1 1 0.10 0 1.44
22 INT111759 Binding of Cpe and Drd2 1 0.01 0.32 1.42
23 INT111762 Positive_regulation of Binding of Cpe and Drd2 1 0.02 0.33 1.42
24 INT134760 Ghrl Regulation of Transcription of Calca 1 0.24 2.71 1.42
25 INT134764 Ghrl Regulation of Gene_expression of NOS3 1 0.02 2.66 1.4
26 INT91305 Binding of Npff and Npffr2 2 0.31 0.64 1.32
27 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3
28 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27
29 INT132465 Ltf Positive_regulation of Nos1 1 0.35 0.05 1.24
30 INT167278 Binding of OPRM1 and REST 1 0.08 0.94 1.24
31 INT108469 Tacr1 Regulation of Transcription of Drd2 1 0.07 0.14 1.2
32 INT200312 Rest Regulation of Oprm1 1 0.23 0.27 1.16
33 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16
34 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13
35 INT142572 D5Pas1 Negative_regulation of Nos1 2 0.02 0.14 1.11
36 INT317527 Binding of Hint1 and Nos1 1 0.27 0.1 1.11
37 INT41175 Adra2a Regulation of Th 1 0.59 0 1.04
38 INT200307 Rest Negative_regulation of Rorb 1 0.00 0.1 1.03
39 INT132464 Ltf Negative_regulation of Positive_regulation of Nos1 1 0.33 0 1.03
40 INT83903 Penk Positive_regulation of Npff 1 0.49 0 1.02
41 INT119914 Olr1714 Negative_regulation of Nos1 1 0.02 0.47 1.01
42 INT21332 Binding of Drd2 and Gm5195 1 0.01 0.26 1
43 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1
44 INT317555 Nos1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
45 INT226128 Positive_regulation of Ghrl Regulation of Prkag1 1 0.06 0.28 0.97
46 INT140068 Binding of GH1 and Ghsr 1 0.00 0.47 0.97
47 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
48 INT127263 Adra2a Regulation of Gene_expression of Jun 1 0.07 1.1 0.95
49 INT295530 Ghrl Regulation of Gene_expression of Ghrh 1 0.30 0.21 0.95
50 INT295547 Ghrl Regulation of Ghrh 1 0.30 0.06 0.9
51 INT317530 Negative_regulation of Binding of Nos1 and Oprm1 1 0.21 0.06 0.9
52 INT28921 Adra2a Positive_regulation of Localization of Prl 1 0.24 0 0.9
53 INT295552 Binding of Ghrl and Ghsr 7 0.40 1.64 0.88
54 INT137563 Ghrl Positive_regulation of Gene_expression of Npy 1 0.59 0 0.87
55 INT200308 Binding of Rest and Rorb 1 0.00 0 0.87
56 INT202254 Binding of COMT and DRD2 1 0.41 0.23 0.86
57 INT43796 Binding of CDS1 and Adra2a 1 0.06 0 0.86
58 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86
59 INT120825 Adcyap1 Positive_regulation of Localization of Nos1 1 0.26 0.62 0.85
60 INT36008 Negative_regulation of Binding of Drd2 and Prl 1 0.01 2.11 0.85
61 INT132318 Ghrl Positive_regulation of Localization of GH1 5 0.32 4.49 0.84
62 INT105970 GH1 Regulation of Ghsr 1 0.04 1.16 0.84
63 INT155761 Binding of Nos1 and Tjp1 1 0.13 1.01 0.82
64 INT155760 Binding of Nos1 and Dlg4 1 0.13 1.01 0.82
65 INT349657 Nos2 Regulation of Regulation of Nos1 1 0.24 0.9 0.8
66 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
67 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79
68 INT142454 Npff Positive_regulation of Gtpbp4 1 0.56 0 0.78
69 INT142455 Binding of Npff and Gtpbp4 1 0.40 0 0.78
70 INT295546 Ghrl Positive_regulation of Ghsr 3 0.39 0.09 0.77
71 INT164364 Binding of DRD2 and SUGT1 2 0.06 0.33 0.77
72 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
73 INT353721 Negative_regulation of Binding of Drd1a and Ghsr 1 0.16 0 0.76
74 INT90120 Jun Positive_regulation of Gene_expression of Nos1 1 0.38 0.39 0.76
75 INT334833 Binding of Drd2 and Ncs1 1 0.05 1.11 0.76
76 INT226122 Ghrl Regulation of Cnr1 1 0.25 0.09 0.76
77 INT353720 Binding of Drd1a and Ghsr 1 0.18 0 0.76
78 INT90117 Jun Regulation of Gene_expression of Nos1 1 0.21 0.39 0.76
79 INT90125 Nfkb1 Regulation of Gene_expression of Nos1 1 0.17 0.39 0.76
80 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76
81 INT353718 Binding of Rbm39 and Ghsr 1 0.01 0 0.76
82 INT90116 Nfkb1 Positive_regulation of Gene_expression of Nos1 1 0.32 0.39 0.76
83 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75
84 INT108611 Adra2a Regulation of Gene_expression of Nos1 1 0.10 0 0.75
85 INT353716 Ghrl Positive_regulation of Vta1 1 0.33 0 0.74
86 INT84283 Binding of Adra2a and Htr1f 1 0.16 0.15 0.74
87 INT327702 Binding of Comt and Drd2 1 0.28 0.27 0.74
88 INT220033 Casp3 Positive_regulation of Gene_expression of Nos1 1 0.05 0.52 0.72
89 INT20688 Adra2a Regulation of Localization of Gh1 1 0.26 0.37 0.7
90 INT81968 Binding of PLEK and Adra2a 1 0.07 0.1 0.7
91 INT106154 Calca Positive_regulation of Nos1 1 0.29 0.2 0.68
92 INT347962 Cpox Negative_regulation of Positive_regulation of Nos1 1 0.02 0.59 0.67
93 INT220032 Nos1 Positive_regulation of Nos3 1 0.32 0.45 0.66
94 INT132152 Adra2a Regulation of Localization of Abat 1 0.03 0 0.66
95 INT220035 Nos1 Positive_regulation of Nos2 1 0.29 0.45 0.66
96 INT153921 Positive_regulation of Adra2a Regulation of Ednrb 1 0.01 0 0.66
97 INT118824 OPA1 Positive_regulation of Gene_expression of Nos1 2 0.03 0.24 0.65
98 INT353722 Rbm39 Positive_regulation of Localization of Ghrl 1 0.01 0 0.65
99 INT167139 Binding of Ghrl and Mln 1 0.04 0.56 0.65
100 INT78663 Dlst Regulation of Nos1 1 0.19 0.91 0.65
101 INT200317 Rest Negative_regulation of Transcription of Oprm1 1 0.31 0 0.64
102 INT209131 Binding of Bcl2a1a and Drd2 1 0.22 0.45 0.62
103 INT19011 Binding of Ghrh and Ghsr 1 0.40 0 0.62
104 INT133707 Npff Positive_regulation of Npffr1 1 0.73 0.73 0.61
105 INT17187 Binding of Adra2a and Fabp6 1 0.16 0.69 0.61
106 INT17186 Positive_regulation of Binding of Adra2a and Fabp6 1 0.21 0.69 0.61
107 INT91306 Binding of Npff and Npffr1 1 0.23 0.17 0.6
108 INT75040 Binding of GHSR and MC1R 1 0.02 0.34 0.6
109 INT142571 Pnoc Positive_regulation of Nos1 1 0.52 0.06 0.57
110 INT41250 Binding of Adra2a and Eef1a1 1 0.06 0.4 0.56
111 INT45258 SLAMF6 Positive_regulation of Drd2 1 0.00 0 0.55
112 INT215644 Binding of Drd2 and Adora2a 1 0.03 0.23 0.55
113 INT271889 Binding of DRD2 and ANKK1 1 0.23 0.36 0.55
114 INT271888 Binding of DRD2 and DNAJC7 1 0.14 0.36 0.55
115 INT303653 Binding of DRD2 and SST 1 0.18 0.45 0.54
116 INT32908 Binding of ADCY1 and Drd2 1 0.00 0 0.54
117 INT25414 Positive_regulation of Drd2 Positive_regulation of Penk 1 0.38 0 0.53
118 INT97425 Prkcg Regulation of Regulation of Nos1 1 0.06 0 0.53
119 INT165045 Drd2 Regulation of Cpe 1 0.07 0 0.52
120 INT165042 Drd2 Regulation of Tac1 1 0.22 0 0.52
121 INT90067 Binding of Oprd1 and Npff 1 0.20 0.09 0.52
122 INT105971 GH1 Regulation of Ghrl 1 0.03 0.75 0.52
123 INT165043 Drd2 Regulation of Cck 1 0.20 0 0.52
124 INT20580 Drd2 Regulation of Akr1d1 1 0.02 0.26 0.51
125 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51
126 INT317537 Oprm1 Positive_regulation of Phosphorylation of Nos1 1 0.16 0 0.5
127 INT140067 GH1 Positive_regulation of Ghsr 1 0.00 0.23 0.49
128 INT200321 Binding of Rest and Negative_regulation of Gene_expression of Oprm1 1 0.36 0.05 0.49
129 INT7851 Man2a2 Positive_regulation of Adra2a 1 0.13 0 0.49
130 INT90121 Nos1 Regulation of Fos 1 0.27 0.25 0.49
131 INT146113 Binding of Adra2a and Lrp1 1 0.01 1.07 0.48
132 INT140066 Ghsr Positive_regulation of GH1 1 0.00 0.23 0.48
133 INT61848 Npff Regulation of Localization of Avp 1 0.26 0.3 0.48
134 INT257220 Binding of Nos1 and Flvcr2 1 0.00 0.17 0.47
135 INT26448 Adra2a Regulation of Positive_regulation of Npy 1 0.06 0 0.46
136 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
137 INT226125 Ghrl Positive_regulation of Cnr1 1 0.44 0.06 0.46
138 INT328385 Binding of GHS and Ghrl 1 0.15 1.89 0.45
139 INT295548 Ghrl Regulation of Regulation of Ghrh 1 0.30 0 0.45
140 INT226126 Negative_regulation of Ghrl Regulation of Prkag1 1 0.06 0.17 0.45
141 INT118208 Ghrl Negative_regulation of Localization of Prl 1 0.39 0 0.44
142 INT86380 Adra2a Regulation of Gene_expression of Tnf 1 0.15 0.79 0.44
143 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
144 INT325391 Binding of Ghrl and Ghsr 2 0.17 0.14 0.43
145 INT323484 Ghsr Positive_regulation of Localization of Ins1 1 0.27 0.87 0.43
146 INT56576 Adra2a Positive_regulation of Localization of Gnrh1 1 0.44 0 0.43
147 INT16586 Binding of Drd2 and Nts 1 0.12 0 0.43
148 INT159349 Zfp956 Negative_regulation of Nos1 1 0.03 0.61 0.43
149 INT328377 Binding of GAST and Ghrl 1 0.03 0.62 0.43
150 INT55395 Binding of Htr1a and Adra2a 1 0.42 0 0.43
151 INT226127 Regulation of Ghrl Regulation of Prkag1 1 0.05 0.07 0.42
152 INT89666 Binding of Adora2a and Drd2 1 0.54 0.4 0.42
153 INT36009 Binding of Drd2 and Prl 1 0.01 1.05 0.42
154 INT295533 Ghrl Regulation of Npy 1 0.23 0.09 0.42
155 INT297229 Binding of Kcnj8 and Abcc8 1 0.03 0 0.42
156 INT111410 Nos1 Regulation of Vip 1 0.00 0 0.41
157 INT200327 Oprm1 Negative_regulation of Gene_expression of Rest 1 0.31 0 0.41
158 INT146273 Binding of Nos1 and Rasd1 1 0.34 0.18 0.41
159 INT111409 Nos1 Regulation of Gene_expression of Vip 1 0.01 0 0.41
160 INT226116 Ghrl Regulation of Positive_regulation of Npy 1 0.17 0 0.41
161 INT34987 Adra2a Positive_regulation of Localization of Gnrhr 1 0.43 0 0.4
162 INT55588 Drd2 Regulation of Transcription of Gad1 1 0.15 0.07 0.4
163 INT134761 Ghrl Regulation of Localization of Tnf 1 0.20 0.76 0.4
164 INT226129 Ghrl Regulation of Localization of Prkag1 1 0.05 0.07 0.4
165 INT55589 Drd2 Regulation of Gad1 1 0.15 0.07 0.4
166 INT133708 Npff Negative_regulation of Phosphorylation of Ppp1r1b 1 0.30 0.41 0.4
167 INT200314 Oprm1 Regulation of Rest 1 0.20 0.1 0.39
168 INT200353 Rest Negative_regulation of Oprm1 1 0.31 0.1 0.39
169 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
170 INT146272 Binding of Nos1 and Nos1ap 1 0.28 0.2 0.39
171 INT201274 Car2 Regulation of Gene_expression of Nos1 1 0.05 1.15 0.38
172 INT200302 Rest Regulation of Rorb 1 0.00 0.07 0.38
173 INT334835 Negative_regulation of Binding of Drd2 and Ncs1 1 0.04 0.56 0.38
174 INT70656 Adra2a Regulation of Gene_expression of Npy 1 0.23 0 0.38
175 INT37247 Binding of Drd1a and Drd2 1 0.20 0 0.37
176 INT327708 Binding of Drd1a and Drd2 1 0.12 0.12 0.37
177 INT320591 Ca2 Positive_regulation of Nos1 1 0.07 0.09 0.37
178 INT16896 GHSR Regulation of GH1 2 0.23 0.24 0.36
179 INT16893 GHSR Positive_regulation of GH1 2 0.26 0.24 0.35
180 INT200333 Binding of Rest and Sp1 1 0.24 0.07 0.35
181 INT200316 Sp1 Regulation of Gene_expression of Rest 1 0.31 0 0.35
182 INT343857 Binding of ABCC8 and LY96 1 0.02 0.96 0.34
183 INT200352 Binding of Rest and Rcor2 1 0.16 0.44 0.34
184 INT127887 SLC6A3 Regulation of Drd2 1 0.34 0.68 0.34
185 INT105768 Binding of Nos1 and Nqo1 1 0.00 0.26 0.34
186 INT90543 Npff Negative_regulation of Regulation of Pnoc 1 0.26 0 0.34
187 INT144448 Nqo1 Regulation of Nos1 1 0.11 0.09 0.34
188 INT144450 Regulation of Nqo1 Regulation of Nos1 1 0.11 0.1 0.34
189 INT118210 Ghrl Negative_regulation of Prl 1 0.53 0 0.33
190 INT67030 Negative_regulation of Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
191 INT334836 Ncs1 Regulation of Drd2 1 0.02 0.48 0.33
192 INT67028 Adra2a Negative_regulation of Nts 1 0.06 0.64 0.33
193 INT67029 Adra2a Negative_regulation of Etf1 1 0.00 0.64 0.33
194 INT109894 Drd2 Positive_regulation of FOS 1 0.01 0 0.33
195 INT226124 Ghrl Positive_regulation of Prkag1 1 0.06 0.24 0.33
196 INT323502 Ghrl Positive_regulation of Localization of Ins1 1 0.15 1.58 0.33
197 INT137561 Ghrl Regulation of Gene_expression of Npy 1 0.53 0 0.32
198 INT31182 Adra2a Regulation of Localization of Gh 1 0.01 0.35 0.32
199 INT78664 Negative_regulation of Nos1 Negative_regulation of Cebpz 1 0.30 0.43 0.32
200 INT137386 Ghrl Regulation of Gene_expression of Pigm 1 0.00 0.36 0.3

Single Events

The table below shows the top 100 pain related interactions that have been reported for negative regulation of insulin secretion. They are ordered first by their pain relevance and then by number of times they were reported in negative regulation of insulin secretion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
2 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
3 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
4 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
5 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
6 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
7 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43
8 INT16455 Gene_expression of Drd2 116 0.78 22.71 38.47
9 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
10 INT4843 Gene_expression of Npff 50 0.78 12.92 36.37
11 INT13501 Binding of Drd2 65 0.48 23.76 35.6
12 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15
13 INT6683 Gene_expression of Drd2 64 0.78 11.31 32.28
14 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43
15 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28
16 INT5604 Positive_regulation of Drd2 47 0.67 10.75 27.41
17 INT7717 Positive_regulation of Adra2a 62 0.70 17.68 27.32
18 INT74688 Regulation of Nos1 55 0.62 22.16 25.3
19 INT12484 Binding of Drd2 45 0.48 15.17 24.72
20 INT49172 Regulation of Nos1 43 0.52 27.53 23.66
21 INT7715 Regulation of Drd2 35 0.62 10.79 22.3
22 INT8248 Binding of Adra2a 43 0.48 6.72 22.17
23 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39
24 INT49774 Binding of DRD2 48 0.48 17.42 20.73
25 INT4841 Localization of Npff 26 0.80 4.36 19.91
26 INT3030 Gene_expression of Adra2a 37 0.68 5.58 19.76
27 INT14114 Binding of Adra2a 30 0.48 4.24 18.53
28 INT16155 Positive_regulation of Npff 25 0.70 6.21 17.58
29 INT12875 Regulation of Adra2a 26 0.45 7.51 17.35
30 INT114025 Transcription of Nos1 20 0.70 16.48 15.63
31 INT26729 Negative_regulation of Drd2 28 0.55 9.32 15.17
32 INT61893 Gene_expression of Ghrl 125 0.75 71.49 15.14
33 INT5674 Gene_expression of Adra2a 34 0.77 6.14 15.13
34 INT74098 Negative_regulation of Gene_expression of Nos1 36 0.59 16.25 14.82
35 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76
36 INT46582 Binding of Npff 20 0.48 1.49 13.99
37 INT4842 Regulation of Npff 13 0.54 4.59 13.62
38 INT5599 Regulation of Drd2 25 0.52 3.07 13.31
39 INT14513 Localization of Ghrl 52 0.78 29.26 11.63
40 INT80251 Binding of Nos1 21 0.30 8.24 11.31
41 INT63773 Gene_expression of DRD2 25 0.78 10.41 10.8
42 INT90114 Regulation of Gene_expression of Nos1 18 0.62 6.38 10.52
43 INT110017 Phosphorylation of Nos1 12 0.60 1.64 10.3
44 INT12455 Negative_regulation of Adra2a 30 0.54 5.63 10.14
45 INT97891 Gene_expression of Ghrl 108 0.77 24.85 9.7
46 INT107291 Positive_regulation of Ghrl 58 0.67 44.6 9.68
47 INT57039 Positive_regulation of Gene_expression of Drd2 16 0.50 1.98 9.48
48 INT17764 Negative_regulation of Drd2 17 0.42 4.63 9.46
49 INT13296 Transcription of Drd2 17 0.66 2.7 9.07
50 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82
51 INT224964 Localization of Ghrl 30 0.59 7.71 8.77
52 INT81597 Transcription of Npff 10 0.69 5.52 8.53
53 INT84672 Negative_regulation of Positive_regulation of Nos1 12 0.48 3.76 8.27
54 INT114023 Positive_regulation of Transcription of Nos1 7 0.60 5.35 8.06
55 INT71381 Localization of Nos1 33 0.79 11.46 8.05
56 INT18190 Regulation of DRD2 11 0.60 9.01 7.63
57 INT75063 Regulation of Gene_expression of Drd2 10 0.62 2.82 7.38
58 INT73760 Transcription of Drd2 14 0.72 2.11 7.19
59 INT6576 Localization of Adra2a 11 0.71 1.49 7.18
60 INT21138 Binding of ADRA2A 16 0.48 5.57 6.8
61 INT4840 Positive_regulation of Localization of Npff 7 0.69 0.79 6.69
62 INT92741 Positive_regulation of Positive_regulation of Nos1 8 0.47 1.44 6.58
63 INT90461 Negative_regulation of DRD2 21 0.53 8.35 6.55
64 INT24460 Localization of Drd2 12 0.73 2.96 6.46
65 INT69499 Binding of Nos1 15 0.36 2.56 6.23
66 INT86772 Localization of Drd2 14 0.80 1.93 6.17
67 INT93658 Transcription of Nos1 16 0.72 6.85 6.16
68 INT81596 Positive_regulation of Gene_expression of Npff 6 0.69 3.41 6.1
69 INT64111 Negative_regulation of Gene_expression of Nos1 22 0.57 8.96 6.02
70 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93
71 INT6681 Positive_regulation of Gene_expression of Drd2 10 0.65 1.78 5.78
72 INT257199 Positive_regulation of Phosphorylation of Nos1 2 0.45 0.68 5.78
73 INT84673 Localization of Nos1 19 0.80 5.01 5.62
74 INT268043 Gene_expression of Abcc8 30 0.71 3.05 5.61
75 INT226106 Negative_regulation of Ghrl 12 0.40 3.98 5.39
76 INT97693 Gene_expression of REST 29 0.75 5.51 5.26
77 INT18661 Localization of Ghsr 32 0.78 3.19 5.2
78 INT32432 Positive_regulation of Binding of Drd2 7 0.67 2.72 5.19
79 INT117855 Negative_regulation of Ghrl 29 0.57 17.52 5
80 INT13650 Positive_regulation of Gene_expression of Adra2a 6 0.50 0.69 4.94
81 INT53959 Negative_regulation of Npff 6 0.57 0.55 4.86
82 INT14125 Positive_regulation of Positive_regulation of Drd2 3 0.35 0.85 4.78
83 INT53442 Gene_expression of Npff 12 0.76 0.57 4.75
84 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69
85 INT149091 Gene_expression of Ghsr 42 0.76 5.11 4.6
86 INT71676 Transcription of DRD2 5 0.69 1.19 4.47
87 INT36007 Negative_regulation of Binding of Drd2 7 0.57 3.22 4.36
88 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
89 INT141285 Positive_regulation of Localization of Ghrl 11 0.63 9.38 3.86
90 INT200248 Gene_expression of Rest 1 0.66 1.25 3.7
91 INT132317 Positive_regulation of Gene_expression of Ghrl 20 0.49 21 3.57
92 INT226114 Binding of Ghrl 18 0.36 4.34 3.54
93 INT118207 Binding of Ghrl 11 0.47 7.39 3.52
94 INT134875 Phosphorylation of Nos1 5 0.70 1.21 3.44
95 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
96 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
97 INT142568 Negative_regulation of Positive_regulation of Nos1 2 0.37 0.25 3.3
98 INT102209 Negative_regulation of Gene_expression of Drd2 5 0.59 0.46 3.17
99 INT10869 Regulation of Npff 3 0.45 0.37 3.15
100 INT136266 Gene_expression of KCNQ1 23 0.64 8.34 3.11
101 INT17389 Negative_regulation of Positive_regulation of Adra2a 6 0.58 0.99 3.06
102 INT199255 Binding of Rest 14 0.41 1.43 2.94
103 INT7931 Positive_regulation of Protein_catabolism of Adra2a 1 0.70 0 2.9
104 INT31923 Positive_regulation of Positive_regulation of Adra2a 7 0.44 1.88 2.89
105 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
106 INT19009 Positive_regulation of Ghsr 17 0.64 5.71 2.78
107 INT31451 Negative_regulation of Gene_expression of Adra2a 4 0.43 1.03 2.72
108 INT49169 Regulation of Negative_regulation of Nos1 3 0.45 4.67 2.7
109 INT123795 Positive_regulation of KCNQ1 13 0.49 3.53 2.65
110 INT35251 Regulation of Ghrl 21 0.60 8.26 2.6
111 INT132411 Positive_regulation of Ghrl 25 0.69 12.05 2.59
112 INT108608 Positive_regulation of Positive_regulation of Nos1 8 0.49 1.66 2.58
113 INT108468 Negative_regulation of Gene_expression of Drd2 3 0.41 0.67 2.58
114 INT118374 Negative_regulation of Npff 2 0.42 0.59 2.56
115 INT323469 Negative_regulation of Localization of Ghrl 4 0.29 0.4 2.49
116 INT43212 Regulation of Gene_expression of Adra2a 4 0.45 0.24 2.48
117 INT124746 Positive_regulation of Npff 2 0.50 1.13 2.44
118 INT12456 Negative_regulation of Positive_regulation of Adra2a 4 0.37 1.35 2.42
119 INT53960 Negative_regulation of Localization of Npff 3 0.38 0.31 2.34
120 INT144792 Negative_regulation of Transcription of Nos1 2 0.43 1.74 2.27
121 INT226105 Regulation of Ghrl 10 0.50 2.36 2.26
122 INT53587 Positive_regulation of Binding of Adra2a 1 0.12 0 2.26
123 INT35210 Gene_expression of Ghsr 39 0.75 6 2.24
124 INT30202 Positive_regulation of GHRL 5 0.44 3.04 2.22
125 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18
126 INT110016 Negative_regulation of Phosphorylation of Nos1 3 0.28 0.47 2.16
127 INT121884 Regulation of Binding of Nos1 2 0.33 1.63 2.15
128 INT34196 Regulation of Binding of Adra2a 2 0.45 0 2.12
129 INT323480 Negative_regulation of Ghsr 4 0.36 0.9 2.06
130 INT31262 Positive_regulation of Binding of Adra2a 4 0.10 1.02 2.04
131 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
132 INT25411 Positive_regulation of Positive_regulation of Drd2 2 0.48 0.5 1.98
133 INT188282 Regulation of Gene_expression of Ghrl 16 0.31 10.08 1.95
134 INT23426 Regulation of ADRA2A 8 0.48 1.81 1.88
135 INT164017 Negative_regulation of Localization of Ghrl 2 0.53 3.12 1.88
136 INT51584 Regulation of KCNQ1 10 0.44 3.21 1.84
137 INT4786 Gene_expression of GHRL 7 0.78 7.94 1.76
138 INT97892 Positive_regulation of Gene_expression of Ghrl 31 0.49 13.43 1.7
139 INT64559 Positive_regulation of Negative_regulation of Nos1 2 0.41 1.58 1.68
140 INT97418 Regulation of Regulation of Nos1 2 0.41 0.94 1.68
141 INT81598 Regulation of Transcription of Npff 1 0.44 0.78 1.68
142 INT135447 Transcription of Abcc8 5 0.63 1.55 1.64
143 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
144 INT153635 Positive_regulation of Gene_expression of REST 10 0.54 1.38 1.6
145 INT19007 Binding of Ghsr 5 0.46 0.46 1.6
146 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
147 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53
148 INT28367 Positive_regulation of REST 10 0.54 2.07 1.52
149 INT87571 Negative_regulation of KCNQ1 6 0.41 1.69 1.51
150 INT7780 Positive_regulation of Negative_regulation of Adra2a 2 0.50 0.09 1.48
151 INT7932 Protein_catabolism of Adra2a 1 1.00 0 1.44
152 INT53632 Regulation of Negative_regulation of Adra2a 1 0.23 0.08 1.41
153 INT75062 Regulation of Transcription of Drd2 1 0.51 0 1.41
154 INT224947 Positive_regulation of Localization of Ghrl 3 0.34 0.48 1.4
155 INT165005 Binding of REST 26 0.43 2.81 1.39
156 INT29262 Negative_regulation of Binding of Adra2a 4 0.40 0.25 1.37
157 INT95815 Regulation of Positive_regulation of Adra2a 4 0.45 1.45 1.32
158 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
159 INT115938 Negative_regulation of Negative_regulation of Nos1 2 0.36 0.27 1.31
160 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
161 INT7847 Positive_regulation of Localization of Adra2a 2 0.40 0.22 1.28
162 INT85613 Positive_regulation of Transcription of Npff 2 0.50 0.67 1.28
163 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26
164 INT15663 Regulation of Transcription of Drd2 2 0.26 0.1 1.25
165 INT151325 Binding of Npff 2 0.32 0.39 1.24
166 INT161750 Transcription of Ghrl 14 0.67 7.05 1.23
167 INT79489 Transcription of Adra2a 2 0.61 2.38 1.22
168 INT109663 Regulation of Gene_expression of Npff 1 0.62 0.65 1.21
169 INT77216 Localization of DRD2 3 0.75 0 1.19
170 INT297217 Localization of Abcc8 1 0.74 1.21 1.18
171 INT144393 Negative_regulation of Negative_regulation of Nos1 2 0.32 0.96 1.15
172 INT132972 Gene_expression of HADH 3 0.65 4.75 1.13
173 INT57852 Regulation of Ghsr 15 0.59 1.02 1.1
174 INT149090 Positive_regulation of Ghsr 10 0.70 2.33 1.06
175 INT108609 Regulation of Localization of Nos1 3 0.45 0 1.06
176 INT89847 Positive_regulation of Localization of Nos1 10 0.49 2.45 1.01
177 INT145864 Gene_expression of Irs1 5 0.71 3.34 1.01
178 INT12976 Negative_regulation of ADRA2A 4 0.50 0.16 1.01
179 INT323462 Regulation of Gene_expression of Ghrl 2 0.27 0.15 1
180 INT202579 Regulation of Gene_expression of DRD2 4 0.41 1.11 0.99
181 INT4839 Regulation of Localization of Npff 1 0.24 0.06 0.97
182 INT20687 Positive_regulation of Regulation of Adra2a 1 0.35 1.07 0.95
183 INT141332 Positive_regulation of Binding of Npff 1 0.21 0 0.94
184 INT134879 Negative_regulation of Phosphorylation of Nos1 1 0.50 0.27 0.93
185 INT297219 Negative_regulation of Abcc8 1 0.54 1.08 0.93
186 INT47039 Regulation of SFRP1 14 0.62 7.44 0.92
187 INT190591 Positive_regulation of Rest 3 0.37 2.52 0.92
188 INT16898 Localization of GHSR 8 0.74 1.76 0.91
189 INT16186 Negative_regulation of HADH 2 0.42 1.17 0.91
190 INT18801 Negative_regulation of Negative_regulation of Adra2a 2 0.43 0 0.91
191 INT75050 Binding of GHSR 3 0.47 0.64 0.89
192 INT353715 Negative_regulation of Gene_expression of Ghsr 1 0.35 0 0.89
193 INT51744 Regulation of Uts2 8 0.56 0.23 0.86
194 INT200255 Localization of Rest 1 0.68 0.14 0.86
195 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85
196 INT11086 Regulation of Positive_regulation of Drd2 2 0.45 1.22 0.84
197 INT137788 Negative_regulation of Positive_regulation of KCNQ1 1 0.21 1.02 0.83
198 INT176174 Gene_expression of Srebf1 16 0.66 6.53 0.82
199 INT165684 Localization of HADH 3 0.73 0.91 0.82
200 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81
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