GO:0046688

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Name response to copper ion
Categary Process
Go Slim No
Go Link GO:0046688
Unique Molecular Interactions 704
Total Molecular Interactions 925
Total Single Events 10116
Pain Genes Associated 35

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for response to copper ion. They are ordered first by their pain relevance and then by number of times they were reported for response to copper ion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT150889 Il1a Regulation of Il10 1 0.22 3.49 2.95
2 INT150886 Il1a Regulation of Il1b 1 0.02 3.46 2.93
3 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
4 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81
5 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
6 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
7 INT267133 Binding of ICAM1 and VCAM1 25 0.32 25.43 1.83
8 INT155460 Tnfrsf1a Positive_regulation of Positive_regulation of Nfkb1 1 0.42 2.39 1.82
9 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
10 INT137207 Tnf Positive_regulation of Nfkb1 3 0.23 2.69 1.71
11 INT155459 Tnfrsf1a Positive_regulation of Nfkb1 1 0.42 2.45 1.63
12 INT145930 ecs Positive_regulation of Gene_expression of Bcl2 1 0.01 2.06 1.34
13 INT131256 Positive_regulation of Nfkb1 Positive_regulation of Gene_expression of Nfkbia 1 0.38 0.94 1.31
14 INT112961 NGF Positive_regulation of ICAM1 1 0.40 0.96 1.28
15 INT177232 ICAM1 Regulation of Gene_expression of Vcam1 1 0.03 5.52 1.28
16 INT42579 SOD1 Negative_regulation of POMC 1 0.16 0.43 1.27
17 INT8409 IL1A Positive_regulation of Positive_regulation of Vip 1 0.01 0.63 1.27
18 INT142431 Cp Positive_regulation of Crh 1 0.31 1.49 1.26
19 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
20 INT151657 Vcam1 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
21 INT151658 F3 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
22 INT334129 Acsm3 Positive_regulation of Gene_expression of Icam1 1 0.22 2.89 1.22
23 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2
24 INT31549 Binding of Dbh and Vip 1 0.32 0 1.08
25 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07
26 INT139230 Icam1 Negative_regulation of Cmklr1 1 0.19 1.13 1.07
27 INT139227 Icam1 Negative_regulation of Timp1 1 0.37 1.13 1.06
28 INT139225 Calca Negative_regulation of Icam1 1 0.44 1.13 1.06
29 INT8410 IL1A Positive_regulation of Vip 1 0.02 0.68 1.05
30 INT139226 Icam1 Negative_regulation of Calca 1 0.44 1.12 1.05
31 INT74934 Regulation of IRF6 Positive_regulation of Nfkb1 1 0.01 0.52 1.02
32 INT74933 IRF6 Positive_regulation of Nfkb1 1 0.02 0.52 1.01
33 INT142202 FL Positive_regulation of Bcl2 1 0.05 0.39 0.99
34 INT130232 Binding of Cat and Sod1 1 0.35 0.3 0.98
35 INT31548 Binding of Th and Dbh 1 0.35 0 0.98
36 INT130231 Positive_regulation of Binding of Cat and Sod1 1 0.46 0.3 0.98
37 INT156508 Nfkb1 Regulation of Positive_regulation of Grin1 1 0.22 0.98 0.98
38 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97
39 INT159111 Il1a Regulation of Gene_expression of Il1b 1 0.49 0.38 0.97
40 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
41 INT289461 IRF6 Positive_regulation of ICAM1 1 0.08 0.61 0.91
42 INT112765 Binding of Nfkb1 and Bcl2 1 0.00 1.37 0.91
43 INT66536 Il1a Regulation of Gene_expression of Fos 1 0.59 0 0.91
44 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
45 INT256646 Tnf Positive_regulation of Positive_regulation of Nfkb1 1 0.22 1.83 0.9
46 INT21944 Il1a Negative_regulation of Gnrh1 1 0.34 0 0.89
47 INT108687 Nfkb1 Regulation of Positive_regulation of Nos2 1 0.50 1.28 0.88
48 INT318462 Nnat Positive_regulation of Nfkb1 1 0.46 0.9 0.88
49 INT152694 Negative_regulation of Nfkb1 Negative_regulation of Bdnf 1 0.24 0.15 0.88
50 INT152697 Nfkb1 Negative_regulation of Ltp 1 0.04 0.15 0.88
51 INT108686 Nfkb1 Regulation of Nos2 1 0.69 1.27 0.88
52 INT152695 Nfkb1 Negative_regulation of Bdnf 1 0.24 0.15 0.88
53 INT96811 Nfkb1 Regulation of Gene_expression of IK 1 0.00 1.06 0.87
54 INT272039 Ddc Positive_regulation of Gene_expression of Aanat 1 0.00 0.26 0.87
55 INT37839 Positive_regulation of Binding of Cyp27b1 and Oprd1 1 0.01 0 0.86
56 INT116555 Olr1627 Negative_regulation of Positive_regulation of Nfkb1 1 0.02 1.51 0.86
57 INT166634 Binding of Bcl2 and Becn1 1 0.20 0.5 0.86
58 INT116557 Olr1627 Negative_regulation of Localization of Nfkb1 1 0.02 1.51 0.85
59 INT151409 Binding of Cp and Cd8b 1 0.16 0 0.84
60 INT116558 Ptpn5 Positive_regulation of Nfkb1 1 0.46 2.01 0.83
61 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8
62 INT245350 Abat Regulation of Dbh 1 0.00 0.37 0.8
63 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77
64 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77
65 INT200097 Negative_regulation of Binding of Il1a and Jun 1 0.00 2.76 0.77
66 INT90118 Jun Regulation of Gene_expression of Nfkb1 1 0.18 0.39 0.76
67 INT90125 Nfkb1 Regulation of Gene_expression of Nos1 1 0.17 0.39 0.76
68 INT200093 Binding of Il1a and Jun 1 0.00 2.64 0.76
69 INT90116 Nfkb1 Positive_regulation of Gene_expression of Nos1 1 0.32 0.39 0.76
70 INT250959 Binding of HLA-B and SOD1 1 0.05 0.75 0.75
71 INT90122 Nfkb1 Positive_regulation of Gene_expression of Fos 1 0.39 0.39 0.75
72 INT218935 Cyp3a23/3a1 Regulation of Bcl2 1 0.00 1.08 0.74
73 INT296097 Acsm3 Negative_regulation of SOD1 1 0.01 1.3 0.72
74 INT5971 Il1a Positive_regulation of Crh 2 0.51 0.57 0.71
75 INT320633 Positive_regulation of MAPK1 Regulation of BCL2 1 0.04 1.21 0.7
76 INT313993 Ros1 Positive_regulation of Nfkb1 1 0.05 1.61 0.68
77 INT250871 Il1a Positive_regulation of Protein_catabolism of Ecm1 1 0.01 1.44 0.68
78 INT152923 Aanat Positive_regulation of Helt 1 0.00 0.42 0.67
79 INT94241 Binding of Cp and Slc2a2 1 0.13 0.81 0.67
80 INT70998 IL1B Regulation of Gene_expression of Icam1 1 0.44 0.95 0.67
81 INT152925 Aanat Positive_regulation of Nanog 1 0.02 0.42 0.67
82 INT152926 Aanat Regulation of Localization of Gabrg1 1 0.01 0.42 0.67
83 INT152924 Aanat Positive_regulation of Sema6a 1 0.04 0.42 0.67
84 INT28975 Ins1 Positive_regulation of Positive_regulation of Dbh 1 0.21 0 0.66
85 INT334133 Acsm3 Positive_regulation of Icam1 1 0.23 1.61 0.66
86 INT66603 TFF2 Positive_regulation of Gene_expression of ICAM1 1 0.02 0 0.64
87 INT116560 Olr1627 Negative_regulation of Binding of Nfkb1 1 0.02 1.28 0.63
88 INT346141 ADM Positive_regulation of Gene_expression of ICAM1 1 0.19 1.75 0.63
89 INT66601 WDR87 Positive_regulation of Gene_expression of ICAM1 1 0.00 0 0.63
90 INT142432 Regulation of Cp Positive_regulation of Crh 1 0.18 0.75 0.63
91 INT66604 SARDH Positive_regulation of Gene_expression of ICAM1 1 0.01 0 0.63
92 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62
93 INT142430 Cp Positive_regulation of Gal 1 0.30 0.74 0.62
94 INT95431 Il1a Regulation of Mmp2 1 0.48 0.25 0.61
95 INT339393 Tlr4 Positive_regulation of Nfkb1 1 0.24 2.06 0.61
96 INT182815 Binding of CD63 and ICAM1 1 0.00 1.63 0.61
97 INT306264 Binding of IL1A and MTX1 1 0.09 0.74 0.61
98 INT95435 Il1a Positive_regulation of Positive_regulation of Mmp3 1 0.59 0.25 0.61
99 INT95436 Il1a Positive_regulation of Mmp3 1 0.59 0.25 0.61
100 INT95434 Mmp9 Positive_regulation of Positive_regulation of Il1a 1 0.42 0.23 0.61
101 INT95432 Il1a Positive_regulation of Positive_regulation of Mmp9 1 0.37 0.25 0.6
102 INT90119 Ntrk2 Regulation of Gene_expression of Nfkb1 1 0.01 0.27 0.6
103 INT222554 Il1a Positive_regulation of Localization of Ngf 1 0.02 0.07 0.6
104 INT140264 Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
105 INT140263 Negative_regulation of Tlr4 Positive_regulation of Nfkb1 1 0.00 0.23 0.59
106 INT94240 Binding of Cp and Ins1 1 0.02 0.7 0.58
107 INT277828 Negative_regulation of Binding of ICAM1 and ITGAL 2 0.22 1.27 0.57
108 INT122313 Nfkb1 Regulation of Gene_expression of Cpox 1 0.00 0.51 0.57
109 INT131810 Nfkb1 Negative_regulation of Localization of Apex1 1 0.01 0.52 0.57
110 INT122314 Nfkb1 Regulation of Cpox 1 0.00 0.51 0.56
111 INT66600 TFF2 Regulation of Positive_regulation of ICAM1 1 0.01 0 0.56
112 INT8401 Il1a Regulation of Gene_expression of Nts 1 0.00 0.38 0.56
113 INT122315 Negative_regulation of Nfkb1 Regulation of Cpox 1 0.00 0.51 0.56
114 INT8395 Il1a Regulation of Gene_expression of Vip 1 0.01 0.38 0.56
115 INT133049 TNF Positive_regulation of ICAM1 4 0.47 2.49 0.54
116 INT10079 Cp Regulation of Trh 1 0.01 0.59 0.53
117 INT8396 Il1a Regulation of Nts 1 0.00 0.38 0.53
118 INT8399 Il1a Regulation of Vip 1 0.00 0.38 0.53
119 INT139750 Ubqln1 Regulation of Dbh 1 0.00 0 0.52
120 INT139751 Dbh Regulation of Localization of Prl 1 0.02 0 0.52
121 INT137137 Binding of HIVEP1 and ICAM1 1 0.01 0.68 0.51
122 INT92997 Positive_regulation of SFTPA1 Positive_regulation of Binding of ICAM1 1 0.15 0.26 0.51
123 INT352521 Cnn1 Positive_regulation of Cp 1 0.00 1.45 0.5
124 INT98737 Src Negative_regulation of Tk1 1 0.22 0.15 0.5
125 INT274625 OPN1MW Positive_regulation of SOD1 1 0.19 0.29 0.5
126 INT289464 Negative_regulation of IRF6 Positive_regulation of ICAM1 1 0.07 0.31 0.5
127 INT98734 Egf Negative_regulation of Tk1 1 0.13 0.15 0.49
128 INT135586 CSF2 Regulation of ICAM1 1 0.13 1.3 0.49
129 INT131809 Nfkb1 Positive_regulation of Gene_expression of Ptgs1 1 0.12 0.73 0.48
130 INT129911 Skiv2l Negative_regulation of Localization of IL1A 1 0.01 0.74 0.48
131 INT168110 Binding of Cnr1 and Dbh 1 0.04 0.64 0.47
132 INT130723 Binding of IL1A and Il1rn 1 0.01 0.59 0.47
133 INT71178 Binding of ITGB2 and Icam1 1 0.45 1.2 0.47
134 INT130724 Negative_regulation of Binding of IL1A and Il1rn 1 0.01 0.59 0.47
135 INT168111 Dbh Positive_regulation of Cnr1 1 0.05 0.64 0.47
136 INT39870 Odc1 Negative_regulation of Tk1 1 0.36 0.8 0.46
137 INT222283 Negative_regulation of Casp1 Negative_regulation of Il1a 1 0.00 0.78 0.46
138 INT87934 Phosphorylation of Nfkbia Positive_regulation of Nfkb1 1 0.02 0.1 0.45
139 INT127399 Negative_regulation of Mdk Negative_regulation of Positive_regulation of Nfkb1 1 0.02 0.7 0.45
140 INT127393 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Nfkb1 1 0.10 0.7 0.45
141 INT112772 Binding of Bcl2 and SGSM3 1 0.02 0.69 0.45
142 INT307781 Apoa1 Positive_regulation of LCAT 1 0.76 1.19 0.45
143 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45
144 INT241914 SOD1 Positive_regulation of Ros1 1 0.00 0.76 0.44
145 INT157451 Binding of Slc6a3 and Dbh 1 0.04 0.48 0.44
146 INT87936 Nfkbia Positive_regulation of Nfkb1 1 0.03 0.1 0.44
147 INT104447 Ido1 Negative_regulation of Binding of Atp7b 1 0.00 0.68 0.43
148 INT264473 Il1a Positive_regulation of Mapk1 1 0.00 0 0.43
149 INT264476 Il1a Positive_regulation of Gene_expression of Mapk8 1 0.04 0 0.43
150 INT264471 Il1a Positive_regulation of Gene_expression of Mapk1 1 0.01 0 0.43
151 INT264475 Il1a Positive_regulation of Mapk8 1 0.04 0 0.43
152 INT264479 Il1a Positive_regulation of Gene_expression of Mapk14 1 0.02 0 0.43
153 INT309143 Dlat Positive_regulation of Bcl2 1 0.06 1.04 0.42
154 INT309152 Dlat Positive_regulation of Gene_expression of Bcl2 1 0.04 1.05 0.42
155 INT159438 seb Positive_regulation of Gene_expression of Il1a 1 0.02 0 0.41
156 INT231303 Binding of Prnp and Helt 1 0.02 3.23 0.41
157 INT159439 sea Positive_regulation of Gene_expression of Il1a 1 0.07 0 0.41
158 INT231304 Prnp Negative_regulation of Grin2d 2 0.38 0.5 0.4
159 INT100598 PRNP Positive_regulation of Gene_expression of IL6 1 0.40 0.23 0.4
160 INT222418 Tlr4 Positive_regulation of Gene_expression of Il1a 1 0.00 0.31 0.39
161 INT288700 Binding of Cp and Tfrc 1 0.40 0 0.39
162 INT34856 Hpd Negative_regulation of Dbh 1 0.00 0 0.39
163 INT200096 Negative_regulation of Il1a Negative_regulation of Gene_expression of Ptgs2 1 0.00 1.45 0.39
164 INT250956 Positive_regulation of Binding of HLA-B and SOD1 1 0.07 0.38 0.38
165 INT264482 Il1a Positive_regulation of Phosphorylation of Mapk14 1 0.02 0 0.37
166 INT249090 FOXL1 Regulation of Regulation of ICAM1 1 0.12 1.03 0.37
167 INT264481 Il1a Positive_regulation of Mapk14 1 0.02 0 0.37
168 INT210952 Il1 Positive_regulation of Gene_expression of Icam1 1 0.01 0.86 0.37
169 INT264480 Il1a Positive_regulation of Phosphorylation of Mapk8 1 0.04 0 0.37
170 INT65059 Slc3a1 Positive_regulation of Nfkb1 1 0.00 0 0.37
171 INT21945 Negative_regulation of Il1a Negative_regulation of LH 1 0.18 0 0.36
172 INT137625 Ntf3 Positive_regulation of Atp7b 1 0.04 0 0.36
173 INT152453 Gsk3b Regulation of Nfkb1 1 0.02 1.68 0.36
174 INT155062 Csf2 Positive_regulation of Transcription of Bcl2 1 0.31 2.91 0.36
175 INT19476 Binding of IL1A and Il6 1 0.00 2.19 0.36
176 INT19477 Binding of IL1A and Csf2 1 0.00 2.19 0.36
177 INT21946 Il1a Negative_regulation of LH 1 0.18 0 0.35
178 INT242363 Binding of Il1a and Il1rn 1 0.05 0.19 0.35
179 INT78893 TNF Regulation of Gene_expression of ICAM1 1 0.24 0.38 0.35
180 INT264555 IL15 Positive_regulation of Gene_expression of BCL2 1 0.02 0.92 0.35
181 INT239398 Atp7b Regulation of OAP 1 0.03 1.1 0.35
182 INT164904 Binding of IL1A and IL33 1 0.39 0.19 0.35
183 INT155061 Stat3 Negative_regulation of Bax 1 0.22 3.71 0.34
184 INT258762 Binding of Dbh and ADHD1 1 0.08 1.61 0.34
185 INT276214 Binding of Nos2 and Nfkb1 1 0.12 0.31 0.34
186 INT193492 Binding of Icam1 and Sele 1 0.06 1.05 0.34
187 INT276209 Negative_regulation of Binding of Nos2 and Nfkb1 1 0.14 0.31 0.34
188 INT113476 IL1A Positive_regulation of Localization of MMP14 1 0.10 0.22 0.34
189 INT97357 IL1A Positive_regulation of Transcription of Timp1 1 0.06 0.47 0.34
190 INT155060 Stat3 Negative_regulation of Bcl2 1 0.21 3.7 0.33
191 INT92870 SON Regulation of IL1A 1 0.01 0.31 0.32
192 INT78063 Il1a Positive_regulation of Il1b 1 0.02 0.07 0.32
193 INT203089 Binding of Il1a and Traf6 1 0.04 0.66 0.32
194 INT203085 Positive_regulation of Binding of Il1a and Myd88 1 0.07 0.65 0.32
195 INT203086 Positive_regulation of Binding of Il1a and Traf6 1 0.06 0.67 0.32
196 INT21947 Il1a Positive_regulation of Localization of Pomc 1 0.48 0 0.32
197 INT203087 Binding of Il1a and Myd88 1 0.05 0.65 0.31
198 INT231306 Prnp Regulation of Grin1 1 0.60 0.35 0.31
199 INT97358 IL1A Regulation of Timp1 1 0.04 0.51 0.31
200 INT122049 Binding of HSD11B1 and Lcat 1 0.21 0.83 0.31

Single Events

The table below shows the top 100 pain related interactions that have been reported for response to copper ion. They are ordered first by their pain relevance and then by number of times they were reported in response to copper ion. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73
2 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6
3 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71
4 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38
5 INT82650 Gene_expression of Bcl2 312 0.78 211.71 55.03
6 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28
7 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55
8 INT65055 Negative_regulation of Nfkb1 83 0.58 44.85 34.94
9 INT65536 Negative_regulation of Positive_regulation of Nfkb1 77 0.59 38.86 33.33
10 INT81530 Gene_expression of Nfkb1 93 0.78 48.58 32.58
11 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73
12 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26
13 INT5966 Localization of Il1a 50 0.78 22.91 26.54
14 INT65537 Positive_regulation of Positive_regulation of Nfkb1 52 0.67 30.6 26.35
15 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48
16 INT11746 Positive_regulation of Il1a 65 0.63 42.94 23.54
17 INT102112 Gene_expression of Prnp 440 0.78 209.32 22.5
18 INT3382 Positive_regulation of Dbh 33 0.70 11.64 21.67
19 INT48407 Positive_regulation of Gene_expression of Icam1 61 0.70 57.91 21.54
20 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61
21 INT14436 Gene_expression of Dbh 42 0.72 9.9 19.85
22 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19
23 INT2960 Regulation of Dbh 32 0.47 10.32 18.94
24 INT93734 Positive_regulation of Gene_expression of Bcl2 76 0.70 61.95 18.46
25 INT5967 Negative_regulation of Il1a 51 0.57 27.09 18.24
26 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72
27 INT86673 Positive_regulation of Bcl2 77 0.70 57.74 17.37
28 INT2432 Positive_regulation of Cp 41 0.67 31.1 16.68
29 INT4073 Localization of Dbh 28 0.81 6.06 16.37
30 INT78480 Localization of Nfkb1 39 0.80 23.14 13.64
31 INT69569 Positive_regulation of Prnp 175 0.70 96.31 13.34
32 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52
33 INT11897 Gene_expression of Atp7b 25 0.13 7.85 12.5
34 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4
35 INT60461 Positive_regulation of Gene_expression of Il1a 40 0.61 17.23 12.35
36 INT65057 Regulation of Nfkb1 28 0.47 16.48 11.62
37 INT19527 Negative_regulation of Gene_expression of Il1a 26 0.51 15.4 11.58
38 INT65713 Localization of ICAM1 42 0.81 39.55 11.49
39 INT81531 Positive_regulation of Gene_expression of Nfkb1 27 0.69 13.9 11.04
40 INT56448 Regulation of ICAM1 52 0.60 55.1 10.96
41 INT27687 Regulation of Cp 20 0.53 9.75 10.8
42 INT56450 Negative_regulation of Gene_expression of Icam1 33 0.52 27.21 10.15
43 INT65058 Binding of Nfkb1 36 0.45 19.87 10.02
44 INT80549 Binding of ICAM1 53 0.47 42.76 9.72
45 INT102110 Positive_regulation of Gene_expression of Bax 42 0.67 35.77 9.51
46 INT63341 Negative_regulation of ICAM1 42 0.59 30.45 9.5
47 INT102106 Positive_regulation of Bax 48 0.67 30.62 9.28
48 INT46273 Gene_expression of PRNP 103 0.78 110.34 9.25
49 INT63338 Regulation of Gene_expression of ICAM1 42 0.62 28.26 9.06
50 INT15768 Gene_expression of Il1a 20 0.71 9.31 8.78
51 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68
52 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52
53 INT86672 Negative_regulation of Bcl2 50 0.53 34.16 8.37
54 INT2512 Negative_regulation of Cp 27 0.51 10.15 8.37
55 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27
56 INT5401 Gene_expression of DBH 17 0.78 1.92 8.01
57 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99
58 INT62944 Regulation of Icam1 33 0.47 23.52 7.94
59 INT12010 Gene_expression of Cp 38 0.65 20.55 7.84
60 INT47546 Binding of Dbh 11 0.44 5.69 7.84
61 INT48404 Regulation of Gene_expression of Icam1 21 0.62 15.1 7.81
62 INT121977 Phosphorylation of Nfkb1 15 0.51 9.83 7.77
63 INT116552 Positive_regulation of Localization of Nfkb1 16 0.61 12.7 7.74
64 INT19475 Positive_regulation of IL1A 20 0.67 17.99 7.57
65 INT81537 Regulation of Gene_expression of Nfkb1 10 0.57 7.09 7.48
66 INT91445 Regulation of Bcl2 50 0.56 38.8 7.41
67 INT102107 Negative_regulation of Gene_expression of Bax 30 0.57 29.48 7.33
68 INT5308 Regulation of Il1a 17 0.44 10.8 7.31
69 INT55957 Positive_regulation of PRNP 57 0.67 37.87 7.11
70 INT21938 Positive_regulation of Atp7b 26 0.10 11.33 7.1
71 INT47540 Binding of Cp 20 0.41 15.54 7.01
72 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91
73 INT93101 Regulation of Gene_expression of Bcl2 26 0.62 18.45 6.71
74 INT72532 Regulation of Gene_expression of Il1a 13 0.54 4.91 6.71
75 INT84685 Regulation of BCL2 67 0.60 72.96 6.65
76 INT65538 Regulation of Positive_regulation of Nfkb1 17 0.51 8.31 6.5
77 INT23034 Positive_regulation of Il1a 15 0.70 8.75 6.29
78 INT11896 Negative_regulation of Atp7b 15 0.11 6.01 6.09
79 INT71727 Negative_regulation of Icam1 25 0.45 17.76 5.73
80 INT100422 Negative_regulation of Gene_expression of Bcl2 46 0.58 28.86 5.7
81 INT58468 Negative_regulation of Gene_expression of IL1A 10 0.58 9.39 5.57
82 INT65712 Positive_regulation of Localization of ICAM1 14 0.70 16.72 5.5
83 INT69572 Localization of Prnp 96 0.81 38.11 5.45
84 INT92398 Negative_regulation of Localization of Nfkb1 17 0.42 11.24 5.4
85 INT91754 Gene_expression of Cp 42 0.77 21.97 5.38
86 INT95232 Gene_expression of Aanat 7 0.68 1.41 5.36
87 INT145929 Regulation of Bax 20 0.60 18.12 5.35
88 INT70613 Negative_regulation of Gene_expression of BCL2 48 0.59 38.91 5.22
89 INT58338 Negative_regulation of Localization of Il1a 8 0.25 3.13 5.18
90 INT73262 Negative_regulation of BCL2 67 0.57 61.01 5.07
91 INT69310 Negative_regulation of IL1A 10 0.43 7.83 5.05
92 INT28176 Localization of Cp 17 0.73 14.3 4.86
93 INT102254 Positive_regulation of Gene_expression of Prnp 72 0.70 38.11 4.81
94 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69
95 INT20196 Negative_regulation of Gene_expression of Atp7b 8 0.07 2.49 4.63
96 INT76884 Positive_regulation of Cp 22 0.69 12.84 4.6
97 INT36767 Localization of Atp7b 11 0.20 4.13 4.5
98 INT50309 Binding of Il1a 22 0.40 5.4 4.49
99 INT59083 Positive_regulation of Gene_expression of IL1A 11 0.70 9.09 4.48
100 INT99504 Negative_regulation of Bax 19 0.56 8.89 4.44
101 INT69570 Binding of Prnp 75 0.48 44.26 4.37
102 INT101957 Transcription of Bcl2 30 0.69 16.57 4.3
103 INT23035 Regulation of Il1a 6 0.60 5.69 4.25
104 INT15462 Negative_regulation of Il1a 4 0.59 4.68 4.17
105 INT84852 Transcription of Nfkb1 12 0.67 4.28 3.84
106 INT19189 Localization of IL1A 14 0.78 9.02 3.78
107 INT70996 Positive_regulation of Positive_regulation of Icam1 8 0.60 6.02 3.74
108 INT105882 Phosphorylation of Bcl2 11 0.59 8.15 3.73
109 INT71885 Protein_catabolism of Nfkb1 8 0.53 5.34 3.69
110 INT109403 Regulation of Gene_expression of BCL2 31 0.60 31.22 3.4
111 INT5400 Positive_regulation of DBH 6 0.70 2.02 3.38
112 INT15801 Positive_regulation of TFRC 11 0.33 6.35 3.3
113 INT102255 Regulation of Prnp 35 0.62 18.97 3.25
114 INT28583 Positive_regulation of Gene_expression of Atp7b 4 0.06 0.34 3.24
115 INT15253 Binding of DBH 7 0.36 3.21 3.17
116 INT44873 Negative_regulation of LCAT 16 0.59 6.92 3.13
117 INT70994 Negative_regulation of Positive_regulation of Icam1 8 0.51 3.49 3.12
118 INT54619 Negative_regulation of Positive_regulation of Il1a 6 0.42 5.68 3.12
119 INT105884 Binding of Bcl2 19 0.35 15.67 3
120 INT28376 Regulation of Localization of Dbh 1 0.31 0 2.87
121 INT65053 Positive_regulation of Binding of Nfkb1 11 0.65 3.78 2.84
122 INT39908 Gene_expression of Cyp27b1 16 0.69 4.8 2.83
123 INT16447 Binding of IL1A 10 0.45 4.01 2.78
124 INT74216 Binding of Icam1 16 0.48 10.11 2.69
125 INT5432 Regulation of Atp7b 7 0.36 0.87 2.65
126 INT2958 Transcription of Dbh 4 0.71 2.57 2.64
127 INT91899 Binding of Sod1 17 0.47 11.56 2.63
128 INT102253 Negative_regulation of Prnp 75 0.59 24.23 2.62
129 INT51753 Negative_regulation of Tfrc 7 0.41 3.47 2.62
130 INT127387 Positive_regulation of Phosphorylation of Nfkb1 4 0.38 3.91 2.59
131 INT31989 Binding of SOD1 43 0.47 19.38 2.55
132 INT2695 Regulation of DBH 5 0.45 1.09 2.48
133 INT135040 Regulation of Gene_expression of Prnp 30 0.62 10.52 2.45
134 INT49984 Localization of Il1a 5 0.77 3.61 2.42
135 INT5968 Positive_regulation of Localization of Il1a 4 0.65 1.36 2.42
136 INT135470 Transcription of Icam1 10 0.63 12.04 2.41
137 INT28971 Positive_regulation of Gene_expression of Dbh 4 0.47 0.58 2.39
138 INT21726 Gene_expression of Tfrc 10 0.74 7.38 2.36
139 INT102146 Phosphorylation of Bax 4 0.66 3.48 2.35
140 INT130230 Positive_regulation of Sod1 3 0.67 1.63 2.3
141 INT72865 Localization of Icam1 12 0.68 8.18 2.24
142 INT61225 Positive_regulation of Cyp27b1 8 0.31 2.32 2.24
143 INT67737 Negative_regulation of Pam 6 0.51 4.08 2.19
144 INT150884 Transcription of Il1a 6 0.47 3.12 2.19
145 INT154970 Localization of Bax 15 0.74 11.12 2.11
146 INT49988 Positive_regulation of Gene_expression of Il1a 2 0.47 1.49 2.11
147 INT2961 Regulation of Regulation of Dbh 3 0.24 0.95 2.05
148 INT86671 Negative_regulation of Positive_regulation of Bcl2 6 0.57 3.83 2.03
149 INT82543 Negative_regulation of Gene_expression of TFRC 4 0.57 1.27 2.03
150 INT96764 Positive_regulation of Gene_expression of SOD1 36 0.61 16.55 1.99
151 INT83332 Regulation of Gene_expression of TFRC 5 0.22 3.03 1.99
152 INT134442 Transcription of Bax 14 0.67 7.6 1.9
153 INT15506 Localization of Cp 11 0.80 4.26 1.9
154 INT71807 Negative_regulation of Cp 18 0.58 8.9 1.88
155 INT29577 Negative_regulation of Cyp27b1 5 0.37 2.41 1.88
156 INT69222 Positive_regulation of Sod1 15 0.61 8.19 1.87
157 INT101108 Localization of Bcl2 16 0.72 11.68 1.86
158 INT105883 Positive_regulation of Phosphorylation of Bcl2 8 0.32 5.67 1.86
159 INT167203 Binding of PRNP 25 0.48 20.09 1.84
160 INT134443 Binding of Bax 10 0.47 5.62 1.84
161 INT22087 Negative_regulation of DBH 3 0.59 1.45 1.84
162 INT145655 Transcription of Sod1 3 0.42 0.92 1.84
163 INT69221 Negative_regulation of Sod1 14 0.56 10.57 1.83
164 INT35368 Positive_regulation of Tk1 9 0.53 4.68 1.81
165 INT34864 Binding of Cp 23 0.47 5.17 1.78
166 INT92402 Negative_regulation of Transcription of Nfkb1 4 0.42 1.75 1.76
167 INT91374 Negative_regulation of Gene_expression of Nfkb1 12 0.58 5.06 1.75
168 INT104883 Positive_regulation of Positive_regulation of Bax 4 0.45 4.05 1.74
169 INT143290 Negative_regulation of Phosphorylation of Nfkb1 2 0.35 2.48 1.73
170 INT89926 Regulation of IL1A 10 0.60 7.12 1.72
171 INT101958 Positive_regulation of Transcription of Bcl2 4 0.50 2.22 1.65
172 INT74932 Negative_regulation of Negative_regulation of Nfkb1 2 0.35 0.73 1.65
173 INT137513 Negative_regulation of Positive_regulation of BCL2 6 0.35 5.3 1.62
174 INT37838 Regulation of Cyp27b1 4 0.27 0.67 1.61
175 INT38998 Negative_regulation of Localization of Atp7b 4 0.11 1.72 1.6
176 INT22785 Negative_regulation of PRNP 12 0.57 5.09 1.57
177 INT70993 Regulation of Positive_regulation of Icam1 2 0.45 1.22 1.57
178 INT27293 Regulation of SOD1 21 0.53 15.73 1.55
179 INT78816 Positive_regulation of Positive_regulation of ICAM1 9 0.68 8.36 1.55
180 INT91900 Localization of Sod1 12 0.77 6.62 1.51
181 INT59795 Regulation of Tfrc 5 0.43 4.43 1.48
182 INT4074 Negative_regulation of Localization of Dbh 4 0.59 0.61 1.48
183 INT117101 Gene_expression of Sod1 18 0.67 7.93 1.47
184 INT92399 Positive_regulation of Transcription of Nfkb1 4 0.49 1.59 1.47
185 INT15798 Positive_regulation of Gene_expression of TFRC 9 0.46 4.99 1.42
186 INT109021 Negative_regulation of Binding of Nfkb1 7 0.39 4.13 1.42
187 INT93005 Positive_regulation of Binding of ICAM1 5 0.68 4.55 1.42
188 INT145658 Negative_regulation of Transcription of Sod1 1 0.34 0.15 1.42
189 INT83464 Positive_regulation of Localization of Icam1 3 0.46 3.71 1.4
190 INT49987 Transcription of Il1a 1 0.68 0.66 1.4
191 INT62824 Negative_regulation of Positive_regulation of ICAM1 7 0.53 2.94 1.39
192 INT112655 Negative_regulation of PAM 3 0.57 0.97 1.39
193 INT63339 Transcription of ICAM1 6 0.69 3.92 1.37
194 INT141131 Positive_regulation of Gene_expression of PRNP 12 0.61 16.6 1.36
195 INT141233 Negative_regulation of Positive_regulation of Dbh 2 0.42 0.39 1.33
196 INT129253 Positive_regulation of Positive_regulation of Il1a 5 0.49 2.97 1.31
197 INT101107 Positive_regulation of Localization of Bcl2 3 0.48 3.13 1.28
198 INT95231 Transcription of Aanat 1 0.53 0.4 1.28
199 INT154969 Positive_regulation of Localization of Bax 4 0.64 3.42 1.27
200 INT162757 Regulation of Localization of Il1a 3 0.37 1.22 1.25
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