GO:0046785

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Name microtubule polymerization
Categary Process
Go Slim No
Go Link GO:0046785
Unique Molecular Interactions 111
Total Molecular Interactions 170
Total Single Events 1216
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for microtubule polymerization. They are ordered first by their pain relevance and then by number of times they were reported for microtubule polymerization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT181493 TRPV4 Regulation of Gene_expression of NGF 1 0.24 0.7 1.07
2 INT263232 Prkcg Positive_regulation of Trpv4 1 0.12 1.1 1.02
3 INT263227 Positive_regulation of Prkcg Regulation of Trpv4 1 0.07 0.95 1
4 INT346204 Binding of S100A10 and TPPP 1 0.02 1.62 0.97
5 INT149386 Binding of Lyn and TRPV4 1 0.40 1.14 0.91
6 INT159688 Trpv4 Negative_regulation of Trpv3 1 0.31 0.41 0.76
7 INT159689 Trpv4 Negative_regulation of Trpv1 1 0.36 0.41 0.76
8 INT159687 Trpv4 Negative_regulation of Trpv2 1 0.32 0.41 0.76
9 INT309735 Binding of CALM3 and TRPV4 1 0.14 0 0.75
10 INT322128 Binding of Ca2 and Trpv4 1 0.03 1.1 0.75
11 INT241247 Binding of Pkd2 and Trpv4 1 0.54 1.22 0.52
12 INT346205 Binding of CD74 and TPPP 1 0.02 0.87 0.51
13 INT263228 Prkcg Regulation of Trpv4 1 0.07 0.36 0.5
14 INT263235 Trpv4 Regulation of Trpv1 1 0.17 0.7 0.5
15 INT322131 Binding of Prkcg and Trpv4 1 0.04 0.75 0.46
16 INT279705 CALM3 Regulation of TRPV4 2 0.08 0 0.33
17 INT346226 Binding of TPPP and Braf 1 0.06 0.6 0.33
18 INT322133 Trpv4 Regulation of Ca2 1 0.04 0.16 0.33
19 INT221918 TRPV4 Positive_regulation of TRPM8 1 0.05 0 0.28
20 INT141870 Binding of Slc2a4 and Cav1 1 0.36 0.38 0.28
21 INT322132 Binding of Mbp and Trpv4 1 0.11 0.39 0.27
22 INT309751 Binding of CA2 and TRPV4 1 0.08 0 0.23
23 INT288582 Binding of Cav1 and Kcnma1 1 0.11 0 0.22
24 INT220528 Ugt1a6b Positive_regulation of Cav1 1 0.01 1.31 0.22
25 INT118435 HGF Positive_regulation of TRPV4 1 0.54 0.13 0.2
26 INT142227 Urb1 Regulation of Trpv4 1 0.02 0.1 0.17
27 INT220520 Ugt1a6b Positive_regulation of Gene_expression of Cav1 1 0.01 0.81 0.17
28 INT142229 Trpa1 Regulation of Trpv4 1 0.15 0.1 0.17
29 INT315030 Binding of Cav1 and Tmie 1 0.03 0.25 0.14
30 INT315032 Binding of Cav1 and Ryr1 1 0.27 0.2 0.14
31 INT182481 Binding of Cav1 and Ighg2b 1 0.10 0 0.12
32 INT182482 Binding of Cav1 and Cxcl16 1 0.07 0 0.12
33 INT311871 Cav1 Regulation of Mch 1 0.01 0.24 0.11
34 INT137672 Baa1 Positive_regulation of Trpv4 1 0.17 0 0.11
35 INT220517 Negative_regulation of Ugt1a6b Positive_regulation of Cav1 1 0.01 0.35 0.1
36 INT28816 Binding of TRPV4 and MND1 1 0.27 0.52 0.1
37 INT165324 Binding of TRPV4 and Trpv4 1 0.11 0.66 0.1
38 INT309724 Regulation of Binding of TYRP1 and TRPV4 1 0.01 0 0.09
39 INT302977 Binding of Cav1 and Smpd2 1 0.08 0.71 0.09
40 INT309754 Binding of TYRP1 and TRPV4 1 0.02 0 0.09
41 INT220511 Cav1 Negative_regulation of Transcription of Ccnd1 1 0.03 0.83 0.09
42 INT309159 Binding of Cav1 and Positive_regulation of Localization of Esr1 1 0.04 0 0.08
43 INT309722 TRPV4 Positive_regulation of CA2 1 0.11 0 0.08
44 INT241246 Pkd2 Negative_regulation of Gene_expression of Trpv4 1 0.48 0.47 0.07
45 INT196124 Trpm5 Negative_regulation of Trpv4 1 0.13 0.08 0.06
46 INT196134 Gopc Negative_regulation of Trpv4 1 0.07 0.08 0.06
47 INT196126 Gopc Negative_regulation of Gene_expression of Trpv4 1 0.15 0.08 0.06
48 INT309732 CALM3 Positive_regulation of Gene_expression of TRPV4 1 0.14 0 0.06
49 INT196131 Trpm7 Negative_regulation of Trpv4 1 0.14 0.08 0.06
50 INT196130 Trpm5 Negative_regulation of Gene_expression of Trpv4 1 0.30 0.08 0.06
51 INT196129 Trpm7 Negative_regulation of Gene_expression of Trpv4 1 0.32 0.08 0.06
52 INT322130 Trpv1 Positive_regulation of Positive_regulation of Trpv4 1 0.15 0.1 0.05
53 INT333034 Trpv4 Positive_regulation of Localization of Car2 1 0.06 0 0.05
54 INT169403 Binding of TRPV1 and Trpv4 1 0.23 0.94 0.05
55 INT343498 Binding of ITIH4 and TPPP 1 0.06 0.64 0.05
56 INT333032 Binding of Trpv4 and Gopc 1 0.05 0 0.04
57 INT267685 Binding of CENPJ and ARID1B 1 0.09 0.58 0.04
58 INT241253 Gene_expression of Trpv4 Positive_regulation of Gene_expression of Pkd2 1 0.52 0.29 0.03
59 INT220512 Cav1 Regulation of Positive_regulation of Cdkn1b 1 0.06 0.85 0.03
60 INT267686 Binding of RYBP and CENPJ 1 0.01 0.12 0.03
61 INT333037 Binding of Agt and Trpv4 1 0.09 0 0.03
62 INT308748 TPPP Regulation of MIR1-1 1 0.04 0.13 0.03
63 INT309744 Binding of GOPC and TRPV4 1 0.09 0 0
64 INT322126 Binding of Trpv4 and Fig4 1 0.02 0 0
65 INT288584 Cav1 Regulation of Gene_expression of Kcnma1 1 0.14 0 0
66 INT288588 Binding of Cav1 and Neu3 1 0.01 0 0
67 INT333035 Positive_regulation of Binding of Agt and Trpv4 1 0.11 0 0
68 INT309745 Negative_regulation of Binding of CALM3 and TRPV4 1 0.12 0 0
69 INT204178 Binding of IFI27 and TPPP 1 0.02 0.35 0
70 INT333030 Binding of Itch and Trpv4 1 0.14 0 0
71 INT249045 CENPJ Regulation of Regulation of LEP 1 0.14 0.81 0
72 INT280961 Binding of Cav1 and Cpox 1 0.04 0 0
73 INT333046 Binding of Trpv4 and ITCH 1 0.39 0 0
74 INT288587 Cav1 Regulation of Binding of Kcnma1 1 0.14 0 0
75 INT236528 Binding of Cav1 and Flna 1 0.06 0.09 0
76 INT333036 Trpv4 Positive_regulation of Gene_expression of Agt 1 0.12 0 0
77 INT288590 Binding of Cav1 and Abhd14a 1 0.00 0 0
78 INT288593 Cav1 Positive_regulation of Binding of Kcnma1 1 0.15 0 0
79 INT261833 Binding of Add3 and Trpv4 1 0.00 0.12 0
80 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0
81 INT169448 Binding of Prkce and Trpv4 1 0.04 0.08 0
82 INT162407 TNF Positive_regulation of Gene_expression of TRPV4 1 0.47 0.22 0
83 INT261840 Binding of Mtap7 and Trpv4 1 0.05 0.12 0
84 INT82675 Binding of Lta and CENPJ 1 0.01 0 0
85 INT261843 Lyn Regulation of Regulation of Trpv4 1 0.03 0.19 0
86 INT288591 Cav1 Positive_regulation of Kcnma1 1 0.15 0 0
87 INT262498 Binding of Aqp1 and Cav1 1 0.03 0.56 0
88 INT298103 Binding of Cav1 and Ca2 1 0.03 0 0
89 INT220518 Cav1 Negative_regulation of Akt1 1 0.04 1.02 0
90 INT309736 PACSIN3 Regulation of TRPV4 1 0.55 0 0
91 INT333044 Positive_regulation of Binding of AGTR1 and Trpv4 1 0.48 0 0
92 INT309728 TRPV4 Positive_regulation of CFP 1 0.10 0 0
93 INT164929 Binding of Calca and Trpv4 1 0.32 0 0
94 INT288592 Binding of Cav1 and Olfr1012 1 0.01 0 0
95 INT249047 CENPJ Negative_regulation of LEP 1 0.22 0.8 0
96 INT298104 Ca2 Negative_regulation of Cav1 1 0.04 0.09 0
97 INT315035 Binding of NAE1 and Cav1 1 0.01 0.7 0
98 INT288586 Cav1 Positive_regulation of Regulation of Kcnma1 1 0.21 0 0
99 INT288583 Negative_regulation of Binding of Cav1 and Kcnma1 1 0.13 0 0
100 INT220526 Binding of Akt1 and Cav1 1 0.03 1.02 0
101 INT288589 Cav1 Regulation of Kcnma1 1 0.19 0.05 0
102 INT333038 Agt Positive_regulation of Positive_regulation of Trpv4 1 0.12 0 0
103 INT333043 Binding of AGTR1 and Trpv4 1 0.50 0 0
104 INT261837 Binding of Aqp5 and Trpv4 1 0.05 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for microtubule polymerization. They are ordered first by their pain relevance and then by number of times they were reported in microtubule polymerization. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT109820 Gene_expression of Trpv4 121 0.78 39.69 33.11
2 INT112174 Gene_expression of Trpv4 47 0.78 26.26 20.09
3 INT119233 Positive_regulation of Trpv4 65 0.70 20.21 17.3
4 INT86698 Gene_expression of Cav1 38 0.78 16.37 11.75
5 INT124702 Positive_regulation of Trpv4 21 0.69 7.14 8.2
6 INT306287 Binding of TPPP 4 0.24 14.81 7.71
7 INT124881 Binding of Trpv4 35 0.47 7.71 6.24
8 INT149385 Positive_regulation of TRPV4 11 0.69 7.22 6.02
9 INT118440 Gene_expression of TRPV4 20 0.71 7.33 6.01
10 INT156296 Regulation of Trpv4 20 0.45 7.84 4.86
11 INT141443 Phosphorylation of Cav1 6 0.82 4.39 4.03
12 INT109821 Negative_regulation of Trpv4 19 0.55 6.86 3.98
13 INT181496 Regulation of TRPV4 3 0.23 3.32 3.23
14 INT112175 Negative_regulation of Gene_expression of Trpv4 8 0.59 3.7 3.12
15 INT168744 Negative_regulation of Regulation of Trpv4 1 0.42 3.26 2.87
16 INT169402 Binding of Trpv4 8 0.47 5.13 2.78
17 INT86703 Positive_regulation of Gene_expression of Cav1 7 0.70 3.58 2.73
18 INT115852 Transcription of Trpv4 9 0.71 2.23 2.65
19 INT28817 Binding of TRPV4 6 0.39 3.92 2.59
20 INT35349 Gene_expression of CENPJ 52 0.57 25.36 2.54
21 INT204185 Gene_expression of TPPP 7 0.22 6.48 2.54
22 INT109822 Negative_regulation of Gene_expression of Trpv4 8 0.55 1.98 2.53
23 INT115199 Localization of Trpv4 12 0.79 3.65 2.5
24 INT159809 Localization of Trpv4 6 0.78 3.67 2.46
25 INT156301 Regulation of Trpv4 11 0.60 2.81 2.35
26 INT156299 Phosphorylation of Trpv4 8 0.80 2.46 2.31
27 INT61784 Positive_regulation of CENPJ 27 0.51 11.46 2.28
28 INT136614 Positive_regulation of Cav1 5 0.46 2.28 2.23
29 INT112089 Gene_expression of Cav1 73 0.75 23.8 1.97
30 INT137670 Positive_regulation of Gene_expression of Trpv4 12 0.68 3.42 1.77
31 INT149153 Positive_regulation of Gene_expression of Trpv4 12 0.70 3.37 1.72
32 INT141444 Positive_regulation of Phosphorylation of Cav1 1 0.70 1.76 1.69
33 INT135955 Positive_regulation of Cav1 17 0.48 7.73 1.61
34 INT161574 Localization of CENPJ 7 0.73 6.11 1.54
35 INT149152 Negative_regulation of Trpv4 5 0.58 1.8 1.52
36 INT141862 Binding of Cav1 11 0.36 1.32 1.25
37 INT149384 Negative_regulation of TRPV4 4 0.43 2.41 1.23
38 INT181497 Regulation of Regulation of TRPV4 1 0.23 0.69 1.08
39 INT261816 Positive_regulation of Localization of Trpv4 2 0.47 1.16 1.07
40 INT27813 Regulation of CENPJ 12 0.29 14.26 0.99
41 INT136613 Negative_regulation of Cav1 2 0.57 2.28 0.96
42 INT141442 Negative_regulation of Phosphorylation of Cav1 1 0.59 0.94 0.87
43 INT156175 Positive_regulation of Positive_regulation of Trpv4 5 0.50 0.86 0.8
44 INT112090 Negative_regulation of Gene_expression of Cav1 8 0.57 3.5 0.78
45 INT158547 Negative_regulation of Positive_regulation of Trpv4 2 0.57 0.47 0.77
46 INT112088 Regulation of Cav1 2 0.44 0.51 0.73
47 INT204180 Positive_regulation of TPPP 4 0.16 3.54 0.71
48 INT263225 Positive_regulation of Positive_regulation of Trpv4 3 0.46 0.75 0.7
49 INT156302 Positive_regulation of Phosphorylation of Trpv4 2 0.46 0.92 0.68
50 INT156303 Regulation of Regulation of Trpv4 2 0.27 0.26 0.63
51 INT86700 Regulation of Cav1 7 0.54 0.92 0.61
52 INT141863 Negative_regulation of Gene_expression of Cav1 4 0.49 1.77 0.58
53 INT158548 Regulation of Gene_expression of Trpv4 3 0.61 1.03 0.57
54 INT125188 Negative_regulation of Transcription of Trpv4 3 0.42 0.44 0.56
55 INT263224 Phosphorylation of Trpv4 2 0.76 0.73 0.49
56 INT137671 Negative_regulation of Positive_regulation of Trpv4 3 0.58 0.25 0.48
57 INT86702 Localization of Cav1 8 0.69 0.76 0.47
58 INT220504 Positive_regulation of Gene_expression of Cav1 11 0.39 6.26 0.43
59 INT166240 Regulation of Gene_expression of Cav1 3 0.51 1.03 0.43
60 INT212307 Regulation of Gene_expression of Trpv4 8 0.44 2.85 0.39
61 INT220506 Binding of Cav1 13 0.45 5.46 0.38
62 INT135953 Negative_regulation of Positive_regulation of Cav1 2 0.37 1.09 0.37
63 INT141867 Positive_regulation of Transcription of Cav1 2 0.52 0.46 0.29
64 INT141868 Transcription of Cav1 2 0.54 1.48 0.29
65 INT141861 Negative_regulation of Binding of Cav1 1 0.44 0.4 0.29
66 INT177643 Binding of CENPJ 12 0.36 8.59 0.22
67 INT135956 Phosphorylation of Cav1 5 0.64 2.24 0.22
68 INT135954 Positive_regulation of Phosphorylation of Cav1 2 0.40 0.64 0.22
69 INT141860 Regulation of Localization of Cav1 1 0.20 0.2 0.22
70 INT118446 Positive_regulation of Transcription of TRPV4 1 0.49 0.26 0.21
71 INT118447 Transcription of TRPV4 1 0.67 0.26 0.21
72 INT92343 Negative_regulation of CENPJ 20 0.57 6.25 0.2
73 INT156172 Transcription of Trpv4 3 0.72 1.19 0.19
74 INT209259 Regulation of Gene_expression of TRPV4 1 0.22 0.93 0.19
75 INT220497 Regulation of Gene_expression of Cav1 4 0.36 1.84 0.18
76 INT86697 Negative_regulation of Regulation of Cav1 1 0.41 0 0.18
77 INT322153 Positive_regulation of Binding of Trpv4 1 0.49 0 0.18
78 INT162409 Positive_regulation of Gene_expression of TRPV4 2 0.45 0 0.16
79 INT145253 Negative_regulation of Cav1 9 0.46 3.02 0.15
80 INT214975 Localization of Cav1 7 0.75 2.7 0.13
81 INT333015 Regulation of Binding of Trpv4 1 0.42 0.43 0.13
82 INT128425 Negative_regulation of TPPP 1 0.07 1.42 0.12
83 INT156173 Positive_regulation of Transcription of Trpv4 1 0.61 0.43 0.1
84 INT309764 Regulation of Binding of TRPV4 1 0.36 0 0.08
85 INT177642 Positive_regulation of Gene_expression of CENPJ 5 0.30 3.25 0.07
86 INT220491 Transcription of Cav1 2 0.54 1.1 0.07
87 INT220500 Positive_regulation of Transcription of Cav1 1 0.16 0.9 0.07
88 INT219535 Negative_regulation of Localization of CENPJ 2 0.41 1.01 0.05
89 INT220502 Positive_regulation of Positive_regulation of Cav1 1 0.24 0.21 0.05
90 INT315009 Regulation of Phosphorylation of Cav1 1 0.36 0.2 0.05
91 INT300713 Regulation of Localization of Cav1 2 0.42 1.37 0.04
92 INT177683 Negative_regulation of Gene_expression of CENPJ 5 0.32 4.27 0.03
93 INT204184 Localization of TPPP 3 0.23 1.65 0.03
94 INT308781 Regulation of TPPP 1 0.26 0.13 0.03
95 INT333110 Negative_regulation of Localization of TPPP 1 0.04 0.53 0.03
96 INT204186 Positive_regulation of Gene_expression of TPPP 2 0.16 1.15 0
97 INT283550 Negative_regulation of Binding of Cav1 2 0.33 0.11 0
98 INT306280 Phosphorylation of TPPP 1 0.53 0.9 0
99 INT333013 Positive_regulation of Protein_catabolism of Trpv4 1 0.43 0 0
100 INT298115 Regulation of Binding of Cav1 1 0.12 0 0
101 INT333010 Positive_regulation of Binding of Trpv4 1 0.47 0 0
102 INT158549 Negative_regulation of Transcription of Trpv4 1 0.42 0 0
103 INT156298 Negative_regulation of Phosphorylation of Trpv4 1 0.43 0.14 0
104 INT322151 Positive_regulation of Localization of Trpv4 1 0.49 0.31 0
105 INT333022 Positive_regulation of Phosphorylation of Trpv4 1 0.47 0 0
106 INT333018 Positive_regulation of Negative_regulation of Trpv4 1 0.43 0 0
107 INT333016 Protein_catabolism of Trpv4 1 0.93 0 0
108 INT315010 Negative_regulation of Transcription of Cav1 1 0.34 0.21 0
109 INT333026 Regulation of Localization of Trpv4 1 0.42 0 0
110 INT285587 Positive_regulation of Localization of Cav1 1 0.11 0.08 0
111 INT309763 Localization of TRPV4 1 0.60 0 0
112 INT333027 Negative_regulation of Binding of Trpv4 1 0.40 0 0
113 INT288574 Negative_regulation of Negative_regulation of Cav1 1 0.33 0.06 0
114 INT158546 Regulation of Transcription of Trpv4 1 0.45 0.17 0
115 INT333017 Negative_regulation of Localization of Trpv4 1 0.40 0 0
116 INT309758 Negative_regulation of Gene_expression of TRPV4 1 0.34 0 0
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