GO:0046813

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Name virion attachment, binding of host cell surface receptor
Categary Process
Go Slim No
Go Link GO:0046813
Unique Molecular Interactions 163
Total Molecular Interactions 257
Total Single Events 3257
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for virion attachment, binding of host cell surface receptor. They are ordered first by their pain relevance and then by number of times they were reported for virion attachment, binding of host cell surface receptor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81
2 INT267133 Binding of ICAM1 and VCAM1 25 0.32 25.43 1.83
3 INT112961 NGF Positive_regulation of ICAM1 1 0.40 0.96 1.28
4 INT177232 ICAM1 Regulation of Gene_expression of Vcam1 1 0.03 5.52 1.28
5 INT151648 TLR4 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
6 INT151657 Vcam1 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
7 INT151658 F3 Regulation of Gene_expression of ICAM1 1 0.00 2.86 1.24
8 INT334129 Acsm3 Positive_regulation of Gene_expression of Icam1 1 0.22 2.89 1.22
9 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07
10 INT139230 Icam1 Negative_regulation of Cmklr1 1 0.19 1.13 1.07
11 INT139227 Icam1 Negative_regulation of Timp1 1 0.37 1.13 1.06
12 INT139225 Calca Negative_regulation of Icam1 1 0.44 1.13 1.06
13 INT139226 Icam1 Negative_regulation of Calca 1 0.44 1.12 1.05
14 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94
15 INT289461 IRF6 Positive_regulation of ICAM1 1 0.08 0.61 0.91
16 INT282129 Il10 Positive_regulation of Icam1 1 0.56 3.12 0.82
17 INT182814 Binding of ICAM1 and PECAM1 2 0.02 3.32 0.77
18 INT70998 IL1B Regulation of Gene_expression of Icam1 1 0.44 0.95 0.67
19 INT334133 Acsm3 Positive_regulation of Icam1 1 0.23 1.61 0.66
20 INT66603 TFF2 Positive_regulation of Gene_expression of ICAM1 1 0.02 0 0.64
21 INT346141 ADM Positive_regulation of Gene_expression of ICAM1 1 0.19 1.75 0.63
22 INT66601 WDR87 Positive_regulation of Gene_expression of ICAM1 1 0.00 0 0.63
23 INT66604 SARDH Positive_regulation of Gene_expression of ICAM1 1 0.01 0 0.63
24 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62
25 INT182815 Binding of CD63 and ICAM1 1 0.00 1.63 0.61
26 INT277828 Negative_regulation of Binding of ICAM1 and ITGAL 2 0.22 1.27 0.57
27 INT66600 TFF2 Regulation of Positive_regulation of ICAM1 1 0.01 0 0.56
28 INT133049 TNF Positive_regulation of ICAM1 4 0.47 2.49 0.54
29 INT137137 Binding of HIVEP1 and ICAM1 1 0.01 0.68 0.51
30 INT92997 Positive_regulation of SFTPA1 Positive_regulation of Binding of ICAM1 1 0.15 0.26 0.51
31 INT56449 Aap Positive_regulation of Icam1 1 0.31 0.75 0.5
32 INT289464 Negative_regulation of IRF6 Positive_regulation of ICAM1 1 0.07 0.31 0.5
33 INT135586 CSF2 Regulation of ICAM1 1 0.13 1.3 0.49
34 INT333151 asa Regulation of Gene_expression of Icam1 1 0.09 0.59 0.48
35 INT333156 Tlx2 Regulation of Gene_expression of Icam1 1 0.06 0.59 0.48
36 INT71178 Binding of ITGB2 and Icam1 1 0.45 1.2 0.47
37 INT103929 Cps1 Negative_regulation of Gene_expression of Icam1 1 0.01 0.13 0.47
38 INT103931 Cps1 Negative_regulation of Icam1 1 0.01 0.07 0.46
39 INT321860 Timp1 Negative_regulation of Icam1 1 0.22 1.13 0.39
40 INT249090 FOXL1 Regulation of Regulation of ICAM1 1 0.12 1.03 0.37
41 INT210952 Il1 Positive_regulation of Gene_expression of Icam1 1 0.01 0.86 0.37
42 INT230499 Gene_expression of Il1rn Negative_regulation of Gene_expression of Icam1 1 0.01 0.85 0.36
43 INT189491 Icam1 Positive_regulation of Transcription of Ccl5 1 0.19 0.64 0.36
44 INT78893 TNF Regulation of Gene_expression of ICAM1 1 0.24 0.38 0.35
45 INT193492 Binding of Icam1 and Sele 1 0.06 1.05 0.34
46 INT230745 Negative_regulation of Ace Negative_regulation of Icam1 1 0.05 1.22 0.29
47 INT282128 Gene_expression of Il10 Positive_regulation of Positive_regulation of Icam1 1 0.37 1.12 0.28
48 INT62550 Il1f5 Regulation of Gene_expression of Icam1 1 0.05 0.44 0.28
49 INT306942 Tnfsf12 Positive_regulation of Gene_expression of ICAM1 1 0.04 1.78 0.27
50 INT170258 Pecam1 Positive_regulation of Icam1 1 0.02 0.79 0.27
51 INT239396 Atp7b Negative_regulation of Gene_expression of Icam1 1 0.07 1.69 0.26
52 INT324064 Olfr1328 Negative_regulation of Gene_expression of Icam1 1 0.02 0.58 0.26
53 INT180718 Binding of SARS and ACE2 3 0.12 7.76 0.25
54 INT128644 Binding of Icam1 and Selp 2 0.39 0.57 0.25
55 INT129220 IFNG Positive_regulation of ICAM1 1 0.09 0.1 0.25
56 INT62549 Il1b Regulation of Icam1 1 0.13 0.39 0.25
57 INT62548 Il1b Regulation of Gene_expression of Icam1 1 0.22 0.39 0.25
58 INT179200 Binding of ICAM1 and IL8 1 0.03 1.02 0.25
59 INT129219 IFNG Positive_regulation of Gene_expression of ICAM1 1 0.13 0.1 0.25
60 INT284589 Binding of ICAM1 and Crp 1 0.00 1.08 0.22
61 INT343910 TLR4 Regulation of Gene_expression of Icam1 1 0.04 1.3 0.22
62 INT229178 TP53 Regulation of ICAM1 1 0.07 0.9 0.21
63 INT141490 Negative_regulation of TNF Positive_regulation of ICAM1 1 0.29 0.58 0.21
64 INT139454 Binding of IGF2R and Icam1 1 0.00 0.4 0.21
65 INT158199 Negative_regulation of Binding of ICAM1 and AHSA1 1 0.15 0.3 0.2
66 INT158220 Positive_regulation of Binding of ICAM1 and TNFSF14 1 0.05 0.3 0.2
67 INT158223 Binding of ICAM1 and TNFSF14 1 0.04 0.3 0.2
68 INT158218 Binding of ICAM1 and AHSA1 1 0.14 0.3 0.2
69 INT158227 Negative_regulation of Binding of ICAM1 and MAPK1 1 0.16 0.3 0.2
70 INT158236 Positive_regulation of Binding of ICAM1 and MAPK1 1 0.19 0.3 0.2
71 INT158226 Binding of ICAM1 and MAPK1 1 0.14 0.3 0.2
72 INT158213 Positive_regulation of Binding of ICAM1 and AHSA1 1 0.18 0.3 0.2
73 INT158229 Negative_regulation of Binding of ICAM1 and TNFSF14 1 0.05 0.3 0.2
74 INT125152 IL1B Regulation of Gene_expression of ICAM1 1 0.50 0.1 0.2
75 INT158215 TNFSF14 Positive_regulation of ICAM1 1 0.05 0.3 0.2
76 INT214590 TIMP1 Regulation of ICAM1 1 0.10 0.29 0.19
77 INT303964 Lep Positive_regulation of Icam1 1 0.24 0.35 0.19
78 INT214591 FOXC1 Regulation of ICAM1 1 0.05 0.29 0.19
79 INT273723 Binding of Icam1 and Trav6-3 1 0.05 1.97 0.19
80 INT214592 OAP Regulation of Gene_expression of ICAM1 1 0.02 0.77 0.19
81 INT323757 Negative_regulation of ACE2 Negative_regulation of ANG 1 0.18 1.73 0.17
82 INT277791 Binding of Icam1 and Itgal 1 0.03 0.37 0.17
83 INT323756 Negative_regulation of ACE2 Positive_regulation of ANG 1 0.19 1.73 0.17
84 INT303967 Lep Positive_regulation of Gene_expression of Icam1 1 0.24 0.58 0.16
85 INT171945 PECAM1 Positive_regulation of Gene_expression of ICAM1 1 0.06 1.66 0.16
86 INT171544 PECAM1 Positive_regulation of ICAM1 1 0.01 0.47 0.16
87 INT171944 ICAM1 Positive_regulation of Gene_expression of PECAM1 1 0.06 1.66 0.16
88 INT273715 Positive_regulation of Binding of Icam1 and Trav6-3 1 0.07 1.51 0.16
89 INT273714 Positive_regulation of Binding of Icam1 and Itgb2 1 0.17 1.46 0.15
90 INT273717 Binding of Icam1 and Itgb2 1 0.17 1.45 0.15
91 INT63981 Sele Regulation of Positive_regulation of Icam1 1 0.17 0.71 0.15
92 INT277012 Binding of PAPPA and ACE2 1 0.02 1.26 0.15
93 INT213010 Hdl1 Negative_regulation of Gene_expression of Icam1 1 0.15 1.01 0.15
94 INT63980 Icam1 Regulation of Positive_regulation of Sele 1 0.17 0.71 0.15
95 INT79229 Binding of Icam1 and Ltbr 1 0.09 0.37 0.14
96 INT289956 Binding of APC and ICAM1 1 0.04 0.5 0.13
97 INT342406 AAVS1 Positive_regulation of Icam1 1 0.26 0.19 0.11
98 INT294742 Lep Positive_regulation of Localization of Icam1 1 0.15 0.48 0.11
99 INT269785 Crp Positive_regulation of ICAM1 1 0.00 1.68 0.11
100 INT297938 Binding of ICAM1 and PAOD1 1 0.06 0.86 0.11
101 INT243215 Myst2 Negative_regulation of Gene_expression of Icam1 1 0.01 0.68 0.1
102 INT120700 PRSS1 Positive_regulation of ICAM1 1 0.15 0.29 0.1
103 INT277089 VEGFA Positive_regulation of Icam1 1 0.02 1.74 0.09
104 INT355580 VEGFA Positive_regulation of ICAM1 1 0.09 1.39 0.09
105 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
106 INT267626 Il1 Positive_regulation of ICAM1 1 0.00 0.79 0.09
107 INT323640 Vcam1 Positive_regulation of Gene_expression of Icam1 1 0.42 1.75 0.08
108 INT346136 ADM Positive_regulation of ICAM1 1 0.20 0.92 0.08
109 INT267137 ICAM1 Regulation of ITGAL 2 0.12 0.57 0.07
110 INT26310 IL1B Positive_regulation of ACE2 1 0.18 0.46 0.07
111 INT284501 Positive_regulation of Binding of ICAM1 and ITGAL 1 0.06 0.2 0.07
112 INT284503 Binding of ICAM1 and ITGAM 1 0.05 0.2 0.07
113 INT186814 MIR181A2HG Regulation of ICAM1 1 0.01 1.05 0.07
114 INT200634 Binding of Agtr2 and Ace2 1 0.00 0.91 0.06
115 INT313506 Binding of ICAM1 and SNRNP70 1 0.02 1.08 0.06
116 INT323755 IGHG3 Negative_regulation of ACE2 1 0.01 1.09 0.05
117 INT313501 Binding of ALOX12 and ICAM1 1 0.10 0.54 0.03
118 INT285407 ELF3 Regulation of ICAM1 1 0.03 0.91 0.03
119 INT251006 ICAM1 Positive_regulation of SELL 1 0.02 0.56 0
120 INT325942 Binding of Icam1 and Ezr 1 0.15 0.39 0
121 INT109816 Ace2 Positive_regulation of Agt 1 0.07 0.3 0
122 INT285289 TNF Positive_regulation of Icam1 1 0.23 1.44 0
123 INT91832 CD81 Negative_regulation of Gene_expression of Hbegf 1 0.01 0.07 0
124 INT170587 GOPC Regulation of Gene_expression of ICAM1 1 0.13 0 0
125 INT249666 Binding of CD81 and GOPC 1 0.06 1.31 0
126 INT74217 Oprl1 Negative_regulation of Positive_regulation of Icam1 1 0.18 0.11 0
127 INT109817 Ace2 Positive_regulation of Angpt1 1 0.05 0.31 0
128 INT249664 Binding of CD81 and CHCHD2 1 0.00 2.51 0
129 INT273716 Binding of Cd28 and Icam1 1 0.09 0 0
130 INT249996 Binding of ICAM1 and GPHA2 1 0.02 2.25 0
131 INT249995 Positive_regulation of Binding of ICAM1 and GPHA2 1 0.02 2.43 0
132 INT170590 RELA Negative_regulation of Gene_expression of ICAM1 1 0.42 0.49 0
133 INT285288 TNF Positive_regulation of Gene_expression of Icam1 1 0.17 2.83 0
134 INT273718 Binding of Icam1 and Vtcn1 1 0.00 0 0
135 INT180749 Binding of Pmel and ACE2 1 0.20 2.14 0
136 INT170588 RELA Regulation of Gene_expression of ICAM1 1 0.26 0 0
137 INT170589 NFKB1 Regulation of Gene_expression of ICAM1 1 0.27 0 0
138 INT109819 Ace2 Regulation of ras 1 0.07 0.3 0
139 INT155171 ICAM1 Regulation of Gene_expression of NOS1 1 0.09 0.08 0
140 INT307808 Ace Positive_regulation of Gene_expression of Ace2 1 0.22 2.43 0
141 INT109815 Ace2 Positive_regulation of Ang 1 0.06 0.3 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for virion attachment, binding of host cell surface receptor. They are ordered first by their pain relevance and then by number of times they were reported in virion attachment, binding of host cell surface receptor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6
2 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71
3 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71
4 INT62827 Positive_regulation of ICAM1 184 0.70 180.95 36.28
5 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55
6 INT48407 Positive_regulation of Gene_expression of Icam1 61 0.70 57.91 21.54
7 INT63340 Positive_regulation of Gene_expression of ICAM1 109 0.70 90.82 20.61
8 INT62826 Negative_regulation of Gene_expression of ICAM1 75 0.58 46.39 17.72
9 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9
10 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16
11 INT79227 Negative_regulation of Gene_expression of Icam1 45 0.59 41.65 14.97
12 INT65713 Localization of ICAM1 42 0.81 39.55 11.49
13 INT56448 Regulation of ICAM1 52 0.60 55.1 10.96
14 INT56450 Negative_regulation of Gene_expression of Icam1 33 0.52 27.21 10.15
15 INT80549 Binding of ICAM1 53 0.47 42.76 9.72
16 INT63341 Negative_regulation of ICAM1 42 0.59 30.45 9.5
17 INT63338 Regulation of Gene_expression of ICAM1 42 0.62 28.26 9.06
18 INT62944 Regulation of Icam1 33 0.47 23.52 7.94
19 INT48404 Regulation of Gene_expression of Icam1 21 0.62 15.1 7.81
20 INT144945 Negative_regulation of Icam1 27 0.50 26.23 7.08
21 INT71727 Negative_regulation of Icam1 25 0.45 17.76 5.73
22 INT65712 Positive_regulation of Localization of ICAM1 14 0.70 16.72 5.5
23 INT144946 Localization of Icam1 21 0.75 21.84 5.33
24 INT56445 Regulation of Icam1 14 0.39 15.4 5.32
25 INT170738 Binding of Icam1 23 0.37 25.49 4.09
26 INT62545 Regulation of Gene_expression of Icam1 17 0.49 14.26 4.06
27 INT70996 Positive_regulation of Positive_regulation of Icam1 8 0.60 6.02 3.74
28 INT48902 Gene_expression of ACE2 22 0.78 17.91 3.24
29 INT70994 Negative_regulation of Positive_regulation of Icam1 8 0.51 3.49 3.12
30 INT74216 Binding of Icam1 16 0.48 10.11 2.69
31 INT135470 Transcription of Icam1 10 0.63 12.04 2.41
32 INT72865 Localization of Icam1 12 0.68 8.18 2.24
33 INT39134 Positive_regulation of Ace2 3 0.14 0.57 2.13
34 INT26311 Negative_regulation of ACE2 8 0.59 16.35 1.94
35 INT39133 Binding of Ace2 3 0.30 0.8 1.89
36 INT56446 Positive_regulation of Positive_regulation of Icam1 7 0.40 8.84 1.64
37 INT70993 Regulation of Positive_regulation of Icam1 2 0.45 1.22 1.57
38 INT78816 Positive_regulation of Positive_regulation of ICAM1 9 0.68 8.36 1.55
39 INT93005 Positive_regulation of Binding of ICAM1 5 0.68 4.55 1.42
40 INT83464 Positive_regulation of Localization of Icam1 3 0.46 3.71 1.4
41 INT62824 Negative_regulation of Positive_regulation of ICAM1 7 0.53 2.94 1.39
42 INT63339 Transcription of ICAM1 6 0.69 3.92 1.37
43 INT261599 Transcription of Icam1 6 0.50 4.55 1.07
44 INT91830 Gene_expression of CD81 4 0.31 2.24 1.03
45 INT281919 Localization of ACE2 4 0.75 2.69 1.02
46 INT107288 Positive_regulation of ACE2 4 0.66 5.48 0.99
47 INT199009 Negative_regulation of Transcription of Icam1 4 0.38 3.81 0.95
48 INT347211 Regulation of Localization of Icam1 1 0.54 7.36 0.79
49 INT342130 Negative_regulation of Localization of ACE2 1 0.01 1.16 0.74
50 INT66607 Regulation of Positive_regulation of ICAM1 3 0.42 2.81 0.71
51 INT48903 Protein_catabolism of ACE2 1 0.08 1.13 0.66
52 INT297304 Regulation of Transcription of Icam1 2 0.21 2.08 0.6
53 INT87458 Binding of CD81 4 0.18 6.02 0.59
54 INT261598 Positive_regulation of Transcription of Icam1 3 0.24 2.56 0.55
55 INT157574 Positive_regulation of Localization of Icam1 1 0.46 0.56 0.51
56 INT91829 Positive_regulation of CD81 1 0.01 0.44 0.51
57 INT78813 Positive_regulation of Transcription of ICAM1 1 0.46 0.16 0.5
58 INT112949 Negative_regulation of Binding of Icam1 2 0.24 1.75 0.47
59 INT174159 Regulation of Binding of Icam1 1 0.03 1.31 0.47
60 INT3907 Gene_expression of Ace2 5 0.54 2.35 0.46
61 INT180739 Binding of ACE2 5 0.37 7.88 0.45
62 INT87456 Regulation of CD81 1 0.17 1.71 0.43
63 INT87457 Negative_regulation of CD81 3 0.37 1.73 0.42
64 INT158244 Phosphorylation of ICAM1 2 0.67 1.33 0.39
65 INT236453 Negative_regulation of Positive_regulation of Icam1 2 0.43 1.95 0.38
66 INT177231 Regulation of Regulation of ICAM1 1 0.06 0.66 0.37
67 INT267145 Negative_regulation of Binding of ICAM1 5 0.57 4.12 0.33
68 INT214613 Regulation of Binding of ICAM1 2 0.28 1.41 0.32
69 INT204566 Negative_regulation of Localization of Icam1 2 0.19 2.11 0.3
70 INT297295 Negative_regulation of Transcription of Icam1 1 0.27 1.57 0.29
71 INT90784 Positive_regulation of Gene_expression of Ace2 3 0.40 1.34 0.27
72 INT187828 Negative_regulation of Gene_expression of ACE2 2 0.29 0.54 0.26
73 INT187827 Regulation of Gene_expression of ACE2 1 0.02 0.45 0.26
74 INT294738 Positive_regulation of Transcription of Icam1 2 0.44 1.74 0.24
75 INT136287 Regulation of Positive_regulation of Icam1 1 0.39 1.32 0.24
76 INT27669 Negative_regulation of Ace2 2 0.42 0.68 0.22
77 INT146186 Negative_regulation of Negative_regulation of Icam1 1 0.11 0.86 0.17
78 INT42556 Negative_regulation of Ace2 2 0.44 2.11 0.16
79 INT112950 Positive_regulation of Binding of Icam1 1 0.28 0.73 0.15
80 INT323762 Regulation of ACE2 1 0.39 1.63 0.12
81 INT109812 Gene_expression of Ace2 4 0.76 5.44 0.11
82 INT214610 Regulation of Localization of ICAM1 1 0.28 0 0.11
83 INT109811 Negative_regulation of Gene_expression of Ace2 1 0.42 0.73 0.11
84 INT330980 Regulation of Negative_regulation of Icam1 1 0.21 0.68 0.09
85 INT281931 Transcription of ACE2 2 0.69 0.57 0.07
86 INT323758 Negative_regulation of Transcription of ACE2 1 0.43 0.47 0.07
87 INT267150 Regulation of Transcription of ICAM1 2 0.26 0.86 0.06
88 INT184935 Protein_catabolism of Ace2 1 0.08 0.21 0.06
89 INT2492 Regulation of Ace2 1 0.13 0 0.06
90 INT107191 Positive_regulation of Regulation of Icam1 1 0.44 0.87 0.05
91 INT281926 Positive_regulation of Gene_expression of ACE2 2 0.47 1.19 0.04
92 INT323759 Regulation of Binding of ACE2 1 0.45 0.22 0.04
93 INT209756 Positive_regulation of Negative_regulation of ACE2 1 0.49 0.38 0
94 INT323761 Negative_regulation of Binding of ACE2 1 0.43 0 0
95 INT354750 Negative_regulation of Negative_regulation of Ace2 1 0.30 0.73 0
96 INT307793 Transcription of Ace2 1 0.25 2.08 0
97 INT139002 Negative_regulation of Negative_regulation of ICAM1 1 0.02 0.1 0
98 INT349474 Regulation of Binding of Icam1 1 0.25 0 0
99 INT354752 Positive_regulation of Negative_regulation of Ace2 1 0.35 0.1 0
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