GO:0046849

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Name bone remodeling
Categary Process
Go Slim No
Go Link GO:0046849
Unique Molecular Interactions 607
Total Molecular Interactions 922
Total Single Events 7895
Pain Genes Associated 22

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for bone remodeling. They are ordered first by their pain relevance and then by number of times they were reported for bone remodeling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48
2 INT57985 Il1b Positive_regulation of Il6 5 0.59 1.66 3.53
3 INT64719 IL1B Positive_regulation of IL6 7 0.41 6.84 3.14
4 INT150888 Il1a Regulation of Il6 1 0.10 3.47 2.93
5 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 0.06 2.01 2.85
6 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79
7 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71
8 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71
9 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36
10 INT124121 IL6 Positive_regulation of CCL2 1 0.26 1.84 2.25
11 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22
12 INT124120 IL6 Regulation of CCL2 1 0.15 1.8 2.22
13 INT94492 Il6 Positive_regulation of Gene_expression of Il1b 1 0.27 3.81 2.19
14 INT94504 Il6 Positive_regulation of Gene_expression of Tnf 1 0.30 3.8 2.19
15 INT94494 Il1b Positive_regulation of Gene_expression of Il6 1 0.27 3.81 2.19
16 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17
17 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08
18 INT70043 IL6 Regulation of IL10 3 0.18 3.59 2.01
19 INT164784 Il6 Positive_regulation of Gene_expression of Cx3cr1 1 0.47 2.37 1.98
20 INT278937 LEP Positive_regulation of Gene_expression of IL6 1 0.32 3.42 1.97
21 INT156509 Il6 Regulation of Positive_regulation of Grin1 1 0.28 1.93 1.93
22 INT51051 IL1B Positive_regulation of Localization of IL6 7 0.57 3.79 1.87
23 INT183781 Binding of IL6 and INS 6 0.22 8.97 1.87
24 INT253895 Binding of Htr1b and Htr1d 1 0.40 0.52 1.74
25 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69
26 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
27 INT158774 Mapk14 Regulation of Il6 1 0.11 0.08 1.57
28 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49
29 INT150885 Il6 Regulation of Il10 1 0.22 1.74 1.47
30 INT155371 VIP Positive_regulation of Localization of IL6 1 0.64 3.37 1.44
31 INT95325 HTR1B Negative_regulation of Calca 1 0.47 0.69 1.43
32 INT236365 Binding of CD40LG and IL6 3 0.20 4.16 1.42
33 INT172834 Binding of IL6 and T2dm2 1 0.00 6.4 1.4
34 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39
35 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36
36 INT160586 IL6 Positive_regulation of Gene_expression of OPRM1 1 0.14 0.54 1.35
37 INT136603 Calca Positive_regulation of Localization of Il6 1 0.67 0.78 1.32
38 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25
39 INT121190 KCNMA1 Positive_regulation of Gene_expression of IL6 1 0.03 0.54 1.24
40 INT121189 KCNMA1 Positive_regulation of IL6 1 0.04 0.54 1.23
41 INT70033 IL6 Regulation of PRF1 1 0.03 1.42 1.21
42 INT70047 IL6 Regulation of Negative_regulation of PRF1 1 0.03 1.42 1.21
43 INT70029 IL6 Regulation of Negative_regulation of IL10 1 0.05 1.42 1.21
44 INT94490 Il6 Positive_regulation of Gene_expression of Avp 1 0.33 1.97 1.15
45 INT94508 Il6 Positive_regulation of Gene_expression of AVP 1 0.42 1.96 1.14
46 INT94496 Il6 Positive_regulation of Gene_expression of Crh 1 0.29 1.94 1.12
47 INT294710 CRP Positive_regulation of Gene_expression of IL6 1 0.63 1.9 1.12
48 INT83616 Binding of IL6 and IL8 5 0.09 5.8 1.11
49 INT267588 IL10 Negative_regulation of Gene_expression of IL6 1 0.01 2.25 1.11
50 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11
51 INT223157 Abat Negative_regulation of Localization of Il6 1 0.05 1.13 1.1
52 INT94495 Tnf Positive_regulation of Gene_expression of Il6 1 0.30 1.9 1.09
53 INT57986 Il1b Regulation of Positive_regulation of Il6 2 0.39 0.23 1.05
54 INT120316 Ghrh Regulation of Il6 1 0.11 0.95 1.05
55 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 0.18 0.95 1.05
56 INT61617 PTGER2 Regulation of Gene_expression of IL6 3 0.11 1.13 1.02
57 INT87025 ZAK Positive_regulation of Gene_expression of IL6 2 0.11 1.59 1.02
58 INT218310 IL6 Positive_regulation of Localization of CRP 1 0.29 3.33 1.02
59 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01
60 INT278946 IL6 Regulation of Gene_expression of IL8 1 0.20 1.9 1
61 INT86181 SFTPA1 Positive_regulation of IL6 1 0.07 0.32 0.99
62 INT244133 DDB1 Positive_regulation of Gene_expression of IL6 1 0.01 1.91 0.99
63 INT154254 Tnf Positive_regulation of Il6 1 0.36 0.94 0.97
64 INT114320 TNF Positive_regulation of Gene_expression of Il6 1 0.07 1.73 0.97
65 INT163390 Il6 Positive_regulation of Gene_expression of Crp 2 0.03 3.42 0.95
66 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94
67 INT285418 IRF6 Positive_regulation of Localization of IL6 3 0.05 0.66 0.93
68 INT134785 Il2rb Regulation of Gene_expression of IL6 1 0.00 1.16 0.92
69 INT134784 Il2rb Regulation of IL6 1 0.00 1.16 0.92
70 INT78062 Il1a Positive_regulation of Localization of Il6 3 0.24 0.48 0.9
71 INT64717 Pomc Positive_regulation of Il6 1 0.13 0.19 0.9
72 INT159962 Rock2 Regulation of Localization of Il6 1 0.09 2.7 0.88
73 INT231716 Binding of IL6 and DIP 1 0.24 1.55 0.87
74 INT199492 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.81 0.86
75 INT199487 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.86
76 INT199491 Il6 Positive_regulation of Positive_regulation of Il6 1 0.00 0.81 0.86
77 INT342986 PTAFR Positive_regulation of Gene_expression of IL6 1 0.14 0.39 0.84
78 INT54992 Il6 Negative_regulation of Prl 1 0.00 0.86 0.84
79 INT105435 TNF Positive_regulation of IL6 5 0.25 4.45 0.83
80 INT86430 IL6 Positive_regulation of Gene_expression of HP 1 0.15 3.61 0.83
81 INT195217 EGFL7 Negative_regulation of Gene_expression of IL6 1 0.06 1.14 0.83
82 INT342999 IL6 Positive_regulation of Gene_expression of HIST2H2AA3 1 0.00 0.4 0.83
83 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8
84 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78
85 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78
86 INT322201 Binding of OAP and SLC34A1 1 0.01 1.49 0.77
87 INT107602 Binding of OPLL and Enpp1 1 0.15 1.12 0.76
88 INT178579 CNTN2 Positive_regulation of IL6 1 0.07 2.17 0.75
89 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73
90 INT248271 IL6 Regulation of Gene_expression of Crp 3 0.27 1.7 0.73
91 INT124352 Il6 Positive_regulation of Positive_regulation of Gorasp2 1 0.10 1.19 0.73
92 INT327994 Il6 Positive_regulation of Gene_expression of ROS1 1 0.05 0.55 0.73
93 INT189303 Atp6v1e1 Positive_regulation of Gene_expression of TPH1 1 0.01 0.16 0.73
94 INT172134 Binding of IL6 and IL15 2 0.01 1.18 0.72
95 INT150996 Sfpq Positive_regulation of Gene_expression of Il6 1 0.04 0.7 0.72
96 INT236364 CD40LG Positive_regulation of Gene_expression of IL6 1 0.25 1.37 0.72
97 INT51005 PDYN Positive_regulation of IL6 1 0.08 0.84 0.72
98 INT159963 Tnf Positive_regulation of Localization of Il6 1 0.12 2.32 0.71
99 INT91700 Il6 Negative_regulation of Oprd1 1 0.23 0 0.7
100 INT346267 Binding of HGF and IL6 1 0.04 0.96 0.7
101 INT278968 LEP Regulation of Gene_expression of IL6 1 0.29 1.11 0.69
102 INT150998 Sfpq Negative_regulation of Gene_expression of Il6 1 0.05 0.69 0.69
103 INT203758 Binding of IL6 and TNF 3 0.26 2.03 0.67
104 INT278953 IL6 Regulation of Gene_expression of PTGER2 1 0.04 1.38 0.67
105 INT164782 Il6 Regulation of Gene_expression of Cx3cr1 1 0.27 0.79 0.67
106 INT231533 IL4 Positive_regulation of LRP5 1 0.00 0.87 0.67
107 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66
108 INT26231 Binding of GSR and HTR1B 1 0.12 0.15 0.66
109 INT285943 IL17A Positive_regulation of Localization of IL6 3 0.20 2.02 0.65
110 INT121812 IL6 Regulation of OPRM1 1 0.22 0.27 0.65
111 INT191494 IL6 Positive_regulation of Binding of CRP 1 0.02 1.65 0.65
112 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63
113 INT121188 Negative_regulation of KCNMA1 Positive_regulation of IL6 1 0.04 0.3 0.63
114 INT155458 Tnfrsf1a Regulation of Gene_expression of Il6 1 0.22 1.11 0.63
115 INT71526 Regulation of Il1b Positive_regulation of Il6 1 0.17 0.14 0.62
116 INT264335 Binding of IL-17 and Positive_regulation of Localization of Il6 1 0.13 1.62 0.62
117 INT71527 Negative_regulation of OPRD1 Negative_regulation of Positive_regulation of Il6 1 0.00 0.15 0.62
118 INT285939 IL6 Positive_regulation of TEP1 1 0.01 1.76 0.61
119 INT169294 EGF Positive_regulation of Localization of IL6 1 0.18 0.13 0.61
120 INT71525 Oprd1 Regulation of Il6 1 0.16 0.19 0.6
121 INT327167 RETNLB Regulation of IL6 1 0.00 2.26 0.6
122 INT91699 Il6 Regulation of Gene_expression of Oprl1 1 0.06 0 0.6
123 INT65014 SOS1 Positive_regulation of Gene_expression of IL6 1 0.45 0.42 0.6
124 INT121813 IL6 Positive_regulation of OPRM1 1 0.28 0.28 0.58
125 INT151461 Olr1745 Negative_regulation of Gene_expression of Il6 1 0.03 0.81 0.57
126 INT142312 Lalba Negative_regulation of Localization of Il6 1 0.23 0.73 0.57
127 INT231712 GAGE2C Regulation of Transcription of IL6 1 0.01 1.01 0.57
128 INT144035 IL6 Positive_regulation of STAT3 4 0.31 2.58 0.56
129 INT307016 IGKV1-17 Positive_regulation of Gene_expression of IL6 1 0.00 1.01 0.56
130 INT70468 Binding of HTR1B and MTG1 1 0.40 0 0.56
131 INT265463 CSPG4 Negative_regulation of Gene_expression of IL6 1 0.06 1.6 0.56
132 INT351365 LPA Positive_regulation of Localization of Il6 1 0.00 1.79 0.54
133 INT231711 GPR174 Regulation of Transcription of IL6 1 0.01 0.96 0.54
134 INT137016 Il6 Positive_regulation of Gene_expression of Acta2 1 0.01 0.75 0.54
135 INT100597 Regulation of RPL21P132 Positive_regulation of IL6 1 0.01 0.45 0.53
136 INT333309 Binding of Htr1b and Adcy1 1 0.01 0 0.53
137 INT285940 Binding of IL6 and IL17A 1 0.11 1.42 0.53
138 INT50935 Mtr Regulation of Gene_expression of Il6 1 0.00 0 0.53
139 INT310532 IL6 Regulation of Regulation of TNF 1 0.34 0.73 0.52
140 INT310531 IL6 Regulation of Regulation of ADIPOQ 1 0.19 0.73 0.52
141 INT117203 Binding of IL1B and IL6 2 0.20 1.4 0.51
142 INT207396 IL6 Positive_regulation of Gene_expression of Tnfsf11 1 0.03 0.95 0.51
143 INT348322 Il6 Positive_regulation of Localization of Crp 1 0.06 3.51 0.51
144 INT62446 Il6 Positive_regulation of Crh 1 0.22 0.05 0.5
145 INT64720 Regulation of IL1B Positive_regulation of IL6 1 0.36 0.65 0.5
146 INT97801 Gm5564 Regulation of Gene_expression of IL6 1 0.00 0.07 0.5
147 INT195220 Binding of CPB2 and IL6 1 0.04 0.5 0.49
148 INT138153 Tgfb1 Regulation of IL6 1 0.01 0.29 0.49
149 INT100595 RPL21P132 Positive_regulation of IL6 1 0.01 0.43 0.49
150 INT61616 TNF Negative_regulation of Gene_expression of IL6 1 0.37 0.33 0.49
151 INT314756 IL6 Positive_regulation of Gene_expression of Crp 2 0.13 4.58 0.48
152 INT260858 IL6 Positive_regulation of Gene_expression of VEGFA 2 0.31 1.77 0.48
153 INT286352 IL6 Positive_regulation of Gene_expression of IL8 2 0.24 1.32 0.48
154 INT115186 IL6 Positive_regulation of Phosphorylation of STAT3 2 0.19 0.35 0.48
155 INT155921 PARP1 Positive_regulation of Gene_expression of IL6 1 0.49 0.44 0.48
156 INT150536 OPRM1 Positive_regulation of Positive_regulation of IL6 1 0.04 0.38 0.48
157 INT150537 OPRM1 Positive_regulation of Negative_regulation of IL6 1 0.04 0.38 0.48
158 INT132448 MIR3607 Negative_regulation of IL6 1 0.01 2.45 0.48
159 INT150539 OPRM1 Positive_regulation of IL6 1 0.04 0.38 0.48
160 INT135589 CSF2 Regulation of IL6 1 0.08 1.27 0.48
161 INT132792 IL4 Positive_regulation of IL6 4 0.28 1.81 0.47
162 INT114754 Il6 Positive_regulation of Gene_expression of Crp 2 0.08 1.67 0.47
163 INT67983 Positive_regulation of HTR1B Positive_regulation of Localization of GHRH 1 0.42 0 0.47
164 INT189151 MTNR1B Positive_regulation of Gene_expression of IL6 1 0.01 0.35 0.47
165 INT231340 INCENP Regulation of Gene_expression of IL6 1 0.01 1.09 0.47
166 INT138152 IL6 Positive_regulation of Transcription of Mmp2 1 0.00 0.23 0.46
167 INT138159 IL6 Positive_regulation of Gene_expression of Mmp3 1 0.00 0.23 0.46
168 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
169 INT67528 PTGER2 Positive_regulation of Gene_expression of IL6 2 0.10 1.38 0.45
170 INT67527 MRXS5 Positive_regulation of Gene_expression of IL6 1 0.21 1.5 0.45
171 INT224282 Binding of Bdnf and Il6 1 0.08 0.26 0.45
172 INT355568 MIF Positive_regulation of IL6 1 0.05 1.05 0.44
173 INT225775 Enpp1 Positive_regulation of Ppi-rs 1 0.06 2.49 0.44
174 INT246023 IL6 Positive_regulation of SOCS2 1 0.18 0.99 0.43
175 INT188194 OSM Regulation of IL6 1 0.16 1.12 0.43
176 INT188211 IL6 Regulation of MAPK1 1 0.16 1.13 0.43
177 INT188207 LIF Regulation of IL6 1 0.17 1.12 0.43
178 INT51475 Binding of Il6 and Tnf 1 0.15 0.61 0.43
179 INT264326 IL-17 Positive_regulation of Gene_expression of Il6 1 0.13 0.83 0.43
180 INT138384 Binding of Htr1b and ADHD1 2 0.07 1.46 0.42
181 INT169288 TRPV1 Positive_regulation of Localization of IL6 1 0.24 0 0.42
182 INT83913 Il1b Positive_regulation of Gene_expression of IL6 1 0.01 0.5 0.41
183 INT91545 Binding of HTR1B and CALCRL 1 0.01 0.09 0.41
184 INT83916 Il1b Positive_regulation of IL6 1 0.02 0.5 0.41
185 INT100594 DCSTAMP Positive_regulation of Gene_expression of IL6 1 0.03 0.24 0.41
186 INT329803 TLR2 Positive_regulation of Positive_regulation of IL6 1 0.01 0.94 0.41
187 INT100598 PRNP Positive_regulation of Gene_expression of IL6 1 0.40 0.23 0.4
188 INT343919 Hspa1a Positive_regulation of Gene_expression of IL6 1 0.02 1.17 0.4
189 INT330598 Binding of Il6 and Fig4 1 0.11 1.78 0.4
190 INT188336 IL6 Positive_regulation of Localization of POMC 1 0.01 0.83 0.4
191 INT294780 IL6 Positive_regulation of IL10 2 0.10 1.26 0.39
192 INT285746 IL6 Regulation of Localization of PRL 1 0.08 1.51 0.39
193 INT285749 IL6 Positive_regulation of Localization of PRL 1 0.08 1.51 0.39
194 INT140574 Ifnb1 Positive_regulation of Il6 1 0.05 0.9 0.39
195 INT143747 Binding of IL6 and LEP 2 0.04 4.05 0.38
196 INT328819 Binding of Il6 and Jak1 1 0.08 0 0.38
197 INT328826 Binding of Il6 and TYK2 1 0.04 0 0.38
198 INT339511 Binding of Tlr4 and Traf6 1 0.05 0.12 0.38
199 INT328818 Regulation of Il6 Positive_regulation of Stat3 1 0.04 0 0.38
200 INT339512 Negative_regulation of Binding of Tlr4 and Traf6 1 0.05 0.17 0.38

Single Events

The table below shows the top 100 pain related interactions that have been reported for bone remodeling. They are ordered first by their pain relevance and then by number of times they were reported in bone remodeling. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22
2 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57
3 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59
4 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38
5 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3
6 INT12082 Localization of IL6 365 0.81 241.78 105.78
7 INT19511 Localization of Il6 212 0.81 118.17 67.67
8 INT10706 Regulation of Il6 150 0.62 93.23 62.34
9 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87
10 INT49993 Positive_regulation of Gene_expression of Il6 149 0.70 88.07 53.78
11 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15
12 INT9210 Regulation of IL6 166 0.62 125.61 49.95
13 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67
14 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53
15 INT56290 Negative_regulation of Gene_expression of Il6 79 0.59 47.98 31.07
16 INT50230 Positive_regulation of Localization of IL6 105 0.70 69.21 29.52
17 INT86437 Binding of IL6 154 0.48 121.22 29.3
18 INT9282 Gene_expression of HTR1B 48 0.75 12.15 22.94
19 INT51474 Binding of Il6 55 0.48 44.99 20.52
20 INT9782 Binding of HTR1B 43 0.47 12.08 19.83
21 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97
22 INT61626 Transcription of IL6 73 0.72 42.04 17.86
23 INT9358 Positive_regulation of HTR1B 26 0.67 11 17.51
24 INT50932 Positive_regulation of Positive_regulation of Il6 36 0.69 24.9 16.12
25 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99
26 INT55256 Negative_regulation of Localization of Il6 38 0.58 16.12 13.67
27 INT55255 Positive_regulation of Localization of Il6 48 0.69 24.88 12.76
28 INT12084 Regulation of Localization of IL6 36 0.61 20.32 12.34
29 INT50933 Transcription of Il6 38 0.72 24.31 11.58
30 INT49396 Negative_regulation of Positive_regulation of Il6 29 0.59 16.39 11.31
31 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8
32 INT115296 Gene_expression of TPH1 18 0.77 7.46 10.18
33 INT11047 Positive_regulation of Positive_regulation of IL6 45 0.66 28.7 9.37
34 INT56580 Positive_regulation of Htr1b 16 0.67 2.95 7.97
35 INT13041 Binding of Htr1b 14 0.47 4.92 7.95
36 INT6892 Regulation of Htr1b 9 0.60 1.32 7.24
37 INT25772 Regulation of HTR1B 15 0.60 3.8 7.17
38 INT15553 Negative_regulation of Htr1b 13 0.41 2.61 7.16
39 INT79822 Gene_expression of Htr1b 10 0.65 2.92 6.27
40 INT64724 Positive_regulation of Transcription of IL6 26 0.69 13.63 5.96
41 INT224530 Positive_regulation of Enpp1 12 0.70 7.03 5.82
42 INT83313 Gene_expression of Htr1b 4 0.75 5.1 5.73
43 INT96510 Localization of Htr1b 6 0.78 2.31 5.51
44 INT64716 Regulation of Positive_regulation of Il6 7 0.54 2.83 5.34
45 INT64723 Regulation of Positive_regulation of IL6 13 0.61 12.59 5.19
46 INT66305 Negative_regulation of HTR1B 9 0.57 1.7 5.15
47 INT52133 Regulation of Localization of Il6 7 0.61 5.35 4.37
48 INT126659 Gene_expression of Tph1 22 0.78 2.04 4.04
49 INT116220 Localization of HTR1B 5 0.78 1.86 3.75
50 INT40368 Positive_regulation of LRP5 5 0.49 3.19 3.51
51 INT64725 Regulation of Transcription of IL6 9 0.45 7.96 3.49
52 INT86082 Localization of Htr1b 4 0.73 2.77 3.46
53 INT59706 Transcription of HTR1B 5 0.69 0.4 3.4
54 INT81403 Positive_regulation of Regulation of Il6 4 0.44 1.81 3.37
55 INT64715 Phosphorylation of Il6 7 0.81 4.24 3.36
56 INT68445 Gene_expression of ENPP1 10 0.70 10.8 3.3
57 INT94947 Positive_regulation of Transcription of Il6 9 0.67 6.91 3.04
58 INT137301 Negative_regulation of Gene_expression of TPH1 5 0.12 1.49 2.98
59 INT207851 Regulation of Enpp1 5 0.45 4.42 2.96
60 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95
61 INT64714 Positive_regulation of Phosphorylation of Il6 4 0.50 3.22 2.67
62 INT9357 Positive_regulation of Positive_regulation of HTR1B 5 0.49 0.88 2.47
63 INT168658 Regulation of Gene_expression of HTR1B 2 0.44 2.11 2.44
64 INT10558 Regulation of Regulation of IL6 6 0.45 4.94 2.33
65 INT115298 Regulation of Gene_expression of TPH1 1 0.22 2.36 2.33
66 INT107597 Binding of Enpp1 5 0.37 3.35 2.23
67 INT58469 Negative_regulation of Positive_regulation of IL6 16 0.42 8.1 2.14
68 INT96403 Transcription of Htr1b 2 0.67 0.81 2.14
69 INT61011 Regulation of TPH1 4 0.22 1.17 2.09
70 INT86083 Positive_regulation of Htr1b 5 0.45 2.01 2.05
71 INT316778 Positive_regulation of Gene_expression of ENPP1 1 0.62 7.2 1.97
72 INT64959 Positive_regulation of Negative_regulation of IL6 5 0.42 5.16 1.86
73 INT253894 Regulation of Localization of Htr1b 1 0.44 0.61 1.82
74 INT224529 Positive_regulation of Gene_expression of Enpp1 15 0.70 12.75 1.81
75 INT155455 Negative_regulation of Phosphorylation of Il6 1 0.31 2.5 1.76
76 INT113378 Negative_regulation of Slc34a1 1 0.00 0 1.75
77 INT332460 Regulation of Binding of Enpp1 1 0.05 0.78 1.5
78 INT98448 Regulation of Binding of Il6 3 0.39 2.6 1.46
79 INT77368 Regulation of Regulation of Il6 3 0.35 1.86 1.45
80 INT98449 Positive_regulation of Binding of Il6 3 0.44 2.96 1.44
81 INT126660 Positive_regulation of Gene_expression of Tph1 5 0.50 0.07 1.43
82 INT87062 Positive_regulation of Binding of IL6 10 0.49 11.8 1.42
83 INT107599 Negative_regulation of Enpp1 8 0.51 6.02 1.24
84 INT153757 Positive_regulation of Mitf 10 0.46 8.38 1.22
85 INT298979 Gene_expression of Traf6 5 0.31 1.75 1.21
86 INT122745 Negative_regulation of TPH1 6 0.59 2.94 1.2
87 INT108519 Binding of Lrp6 8 0.44 1.47 1.19
88 INT190075 Regulation of Transcription of Il6 2 0.45 2.17 1.18
89 INT118258 Positive_regulation of ENPP1 3 0.62 4.26 1.16
90 INT35095 Negative_regulation of Notch2 3 0.36 0.06 1.15
91 INT66306 Negative_regulation of Transcription of HTR1B 1 0.42 0.14 1.15
92 INT10559 Negative_regulation of Regulation of IL6 4 0.37 1.76 1.1
93 INT134260 Negative_regulation of Transcription of Il6 2 0.25 1.39 0.99
94 INT152021 Regulation of Negative_regulation of IL6 3 0.32 1.38 0.98
95 INT115294 Regulation of Regulation of TPH1 2 0.10 1 0.98
96 INT64958 Negative_regulation of Transcription of IL6 6 0.50 3.58 0.92
97 INT248421 Regulation of Tph1 1 0.27 0.89 0.87
98 INT115192 Phosphorylation of IL6 7 0.70 1.55 0.84
99 INT72334 Negative_regulation of LRP5 7 0.35 1.71 0.81
100 INT86084 Negative_regulation of Regulation of Htr1b 1 0.35 0.23 0.8
101 INT86086 Regulation of Htr1b 1 0.37 0.23 0.79
102 INT208774 Positive_regulation of TPH1 2 0.50 0.71 0.78
103 INT86085 Negative_regulation of Htr1b 1 0.48 0.25 0.76
104 INT40369 Gene_expression of LRP5 8 0.55 5.63 0.74
105 INT149014 Negative_regulation of Tph1 5 0.58 1.43 0.74
106 INT57510 Regulation of Notch2 1 0.05 0 0.73
107 INT158354 Negative_regulation of Binding of Il6 2 0.20 2.21 0.71
108 INT231558 Regulation of LRP5 2 0.24 1.02 0.68
109 INT35098 Localization of Enpp1 4 0.75 0.81 0.67
110 INT253893 Negative_regulation of Gene_expression of Htr1b 1 0.41 0.08 0.67
111 INT149013 Positive_regulation of Tph1 3 0.47 1.1 0.65
112 INT123722 Positive_regulation of Localization of Htr1b 1 0.49 0.19 0.63
113 INT188799 Positive_regulation of Protein_catabolism of Traf6 2 0.19 1.98 0.62
114 INT264490 Regulation of Negative_regulation of Il6 2 0.23 1.18 0.6
115 INT213774 Positive_regulation of Positive_regulation of Mitf 1 0.31 1.53 0.58
116 INT40367 Positive_regulation of Gene_expression of LRP5 1 0.09 0 0.57
117 INT188433 Negative_regulation of Binding of IL6 6 0.42 2.03 0.56
118 INT61025 Negative_regulation of Negative_regulation of Il6 3 0.43 1.15 0.56
119 INT116221 Positive_regulation of Localization of HTR1B 1 0.49 0.07 0.56
120 INT77516 Negative_regulation of Positive_regulation of Htr1b 1 0.41 0.07 0.55
121 INT133526 Regulation of Transcription of HTR1B 1 0.26 0 0.55
122 INT79888 Gene_expression of Notch2 3 0.43 0.39 0.54
123 INT61009 Negative_regulation of Regulation of TPH1 1 0.00 0 0.5
124 INT70469 Binding of Htr1b 1 0.01 0 0.49
125 INT115189 Regulation of Phosphorylation of IL6 1 0.04 0 0.48
126 INT153758 Binding of Mitf 5 0.47 2.5 0.46
127 INT240020 Regulation of Binding of IL6 4 0.36 4.38 0.46
128 INT188800 Protein_catabolism of Traf6 2 0.40 1.6 0.45
129 INT322202 Gene_expression of SLC34A1 1 0.04 1.01 0.45
130 INT98447 Positive_regulation of Negative_regulation of Il6 1 0.44 0.75 0.45
131 INT75982 Positive_regulation of Binding of Htr1b 1 0.49 0 0.43
132 INT235660 Gene_expression of EPHA2 27 0.75 23.46 0.4
133 INT225772 Regulation of Gene_expression of Enpp1 1 0.62 1.6 0.4
134 INT35096 Negative_regulation of Negative_regulation of Notch2 1 0.36 0 0.4
135 INT97450 Gene_expression of Mitf 36 0.75 17.22 0.39
136 INT82552 Negative_regulation of Regulation of Il6 2 0.38 1.43 0.36
137 INT235655 Positive_regulation of Gene_expression of EPHA2 14 0.67 13.48 0.35
138 INT217464 Binding of Traf6 5 0.29 1.28 0.35
139 INT332750 Regulation of Gene_expression of Tph1 1 0.11 0 0.33
140 INT235658 Positive_regulation of EPHA2 4 0.67 3.42 0.32
141 INT203075 Positive_regulation of Traf6 1 0.16 0.67 0.32
142 INT203074 Positive_regulation of Positive_regulation of Traf6 1 0.16 0.67 0.32
143 INT143536 Protein_catabolism of Il6 2 0.69 1.89 0.31
144 INT80207 Positive_regulation of Gene_expression of HTR1B 1 0.49 0 0.31
145 INT109156 Negative_regulation of ENPP1 2 0.34 1.34 0.29
146 INT297804 Regulation of Lrp5 6 0.60 2.31 0.27
147 INT335875 Regulation of Lrp6 1 0.57 0.43 0.27
148 INT254427 Binding of Lrp5 10 0.48 5.43 0.26
149 INT334543 Negative_regulation of Positive_regulation of LRP5 1 0.23 1.81 0.25
150 INT298665 Positive_regulation of Protein_catabolism of IL6 1 0.09 2.03 0.25
151 INT131612 Negative_regulation of Mitf 3 0.56 3.91 0.23
152 INT191481 Negative_regulation of Positive_regulation of HTR1B 1 0.41 0.07 0.23
153 INT173655 Binding of LRP5 10 0.39 3.06 0.22
154 INT210927 Positive_regulation of Traf6 4 0.32 0.99 0.22
155 INT254173 Transcription of Traf6 1 0.25 0.26 0.21
156 INT335879 Negative_regulation of Gene_expression of Tph1 1 0.19 0.15 0.21
157 INT352913 Regulation of EPHA2 1 0.05 0.74 0.2
158 INT254429 Negative_regulation of Lrp5 4 0.57 1.95 0.18
159 INT97451 Negative_regulation of Gene_expression of Mitf 3 0.41 0.88 0.17
160 INT335861 Localization of Lrp6 1 0.69 0.54 0.17
161 INT175900 Regulation of ENPP1 1 0.00 1.96 0.16
162 INT252419 Phosphorylation of Enpp1 1 0.08 0.21 0.16
163 INT248417 Binding of Tph1 1 0.37 1.16 0.16
164 INT213794 Phosphorylation of Mitf 2 0.42 2.56 0.15
165 INT188688 Regulation of Traf6 1 0.24 0.15 0.15
166 INT37256 Binding of NOTCH2 2 0.22 1.35 0.14
167 INT225771 Negative_regulation of Gene_expression of Enpp1 4 0.43 3.68 0.13
168 INT188222 Positive_regulation of Regulation of IL6 2 0.29 0.51 0.13
169 INT248416 Phosphorylation of Tph1 1 0.80 1.04 0.13
170 INT248422 Negative_regulation of Phosphorylation of Tph1 1 0.42 1.04 0.13
171 INT298669 Negative_regulation of Protein_catabolism of IL6 1 0.08 1.02 0.13
172 INT213771 Positive_regulation of Gene_expression of Mitf 4 0.48 2.01 0.12
173 INT213766 Regulation of Mitf 6 0.44 3.18 0.1
174 INT208775 Binding of TPH1 1 0.37 0.61 0.1
175 INT97449 Transcription of Mitf 4 0.69 4.28 0.09
176 INT268076 Positive_regulation of Positive_regulation of Tph1 1 0.28 0.83 0.08
177 INT300142 Positive_regulation of NOTCH2 1 0.16 1.26 0.07
178 INT76244 Negative_regulation of Negative_regulation of HTR1B 1 0.41 0 0.07
179 INT200429 Positive_regulation of Negative_regulation of TPH1 1 0.01 0.24 0.07
180 INT254426 Gene_expression of Lrp5 5 0.67 3.28 0.06
181 INT189231 Binding of ENPP1 1 0.07 0.56 0.06
182 INT136925 Gene_expression of NOTCH2 2 0.61 0.56 0.05
183 INT335865 Positive_regulation of Phosphorylation of Lrp6 1 0.64 0.46 0.05
184 INT335862 Phosphorylation of Lrp6 1 0.76 0.37 0.05
185 INT242172 Protein_catabolism of LRP5 1 0.64 0.06 0.04
186 INT319131 Positive_regulation of Lrp5 1 0.43 0.36 0.03
187 INT334994 Gene_expression of Slc34a1 1 0.10 0.62 0.03
188 INT319969 Positive_regulation of Negative_regulation of Enpp1 1 0.06 0.77 0.03
189 INT336399 Transcription of EPHA2 1 0.24 2.21 0.03
190 INT235654 Binding of EPHA2 5 0.36 4.26 0
191 INT290461 Regulation of Gene_expression of Mitf 3 0.59 3.13 0
192 INT297757 Transcription of Lrp5 2 0.68 0.82 0
193 INT297820 Regulation of Transcription of Lrp5 2 0.44 0.83 0
194 INT163086 Positive_regulation of Notch2 2 0.31 1.29 0
195 INT307613 Phosphorylation of LRP5 1 0.08 0.1 0
196 INT138234 Transcription of Tph1 1 0.66 0 0
197 INT290459 Regulation of Transcription of Mitf 1 0.44 0.2 0
198 INT173644 Negative_regulation of Gene_expression of LRP5 1 0.15 0.59 0
199 INT230169 Positive_regulation of Gene_expression of NOTCH2 1 0.29 0.12 0
200 INT335872 Positive_regulation of Gene_expression of Lrp6 1 0.46 0.18 0
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