GO:0046872

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Name metal ion binding
Categary Function
Go Slim No
Go Link GO:0046872
Unique Molecular Interactions 11167
Total Molecular Interactions 14912
Total Single Events 142123
Pain Genes Associated 1392

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for metal ion binding. They are ordered first by their pain relevance and then by number of times they were reported for metal ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2
2 INT206768 TP53 Positive_regulation of Ltp 2 0.01 5.83 10.21
3 INT26468 Ghrh Positive_regulation of Localization of Gh 21 0.37 3.26 9.21
4 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54
5 INT269444 Binding of RAB5A and HHIP 1 0.04 0 5.79
6 INT9546 Binding of Adarb1 and Penk 5 0.03 0 5.1
7 INT10844 Ghrh Regulation of Gh 13 0.13 4.77 4.71
8 INT51497 Cck Negative_regulation of Localization of Trim13 1 0.34 0 4.53
9 INT32444 Binding of Cpe and Pomc 2 0.22 0 4.47
10 INT36536 PRSS1 Positive_regulation of PENK 1 0.24 0.86 4.39
11 INT111758 Binding of Drd2 and Insrr 1 0.01 0.94 4.33
12 INT16221 Ghrh Positive_regulation of Gh 8 0.21 1.89 4.08
13 INT29240 Binding of POMC and YY1 5 0.40 0.17 4.06
14 INT11248 Gh Positive_regulation of Ghrh 2 0.26 0.09 4.04
15 INT95730 Binding of CP and SPINK1 2 0.19 5.65 4.02
16 INT200322 Binding of Rest and Sp3 1 0.39 2.93 3.98
17 INT32911 Binding of Insrr and Rbm39 2 0.00 0 3.95
18 INT130625 Prkcg Regulation of Prkaca 1 0.23 1.32 3.87
19 INT317517 Binding of Nos1 and Oprm1 1 0.17 0.22 3.85
20 INT107331 Binding of PPBP and Adarb1 1 0.01 0 3.67
21 INT115690 Negative_regulation of Prkcg Negative_regulation of Gene_expression of Fos 1 0.47 0.72 3.63
22 INT349583 Aap Positive_regulation of Gene_expression of Cyp2e1 1 0.18 1.57 3.59
23 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38
24 INT215943 Binding of Mmp14 and Timp2 1 0.21 1.59 3.33
25 INT276676 Prkcg Regulation of Nav1 1 0.30 0.82 3.29
26 INT108472 Binding of NOS1 and PNOC 1 0.32 0.64 3.27
27 INT349584 Binding of Cyp2e1 and Aap 1 0.10 1.56 3.24
28 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
29 INT108810 Esr1 Positive_regulation of Binding of Oprm1 1 0.51 1.79 3.22
30 INT13729 GHRH Positive_regulation of Localization of GH1 13 0.62 0.59 3.2
31 INT270949 Binding of Slc6a3 and Cpe 1 0.28 0.25 3.19
32 INT91271 Mtr Regulation of Gene_expression of Il6 1 0.20 0 3.17
33 INT128513 Pnoc Regulation of Adarb1 1 0.01 0.92 3.14
34 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
35 INT94204 NCOR2 Regulation of Gene_expression of SP5 1 0.02 2.15 3.12
36 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11
37 INT161164 Prkcg Regulation of Phosphorylation of Creb1 3 0.41 0.62 3.11
38 INT276679 Prkcg Positive_regulation of Positive_regulation of Nkx1-1 1 0.07 0.94 3.08
39 INT36535 PRSS1 Positive_regulation of Regulation of PENK 1 0.23 0.54 3.06
40 INT102284 Binding of Grin1 and Grin2a 5 0.27 1.79 3.01
41 INT123451 Binding of YY1 and Adra2a 1 0.37 0 2.98
42 INT118158 Binding of Prkca and Prkcz 1 0.07 1.14 2.98
43 INT42728 Binding of PRLR and Cpe 1 0.00 0 2.91
44 INT150632 Ea1 Negative_regulation of Mpo 1 0.17 1.55 2.9
45 INT111757 Positive_regulation of Binding of Drd2 and Insrr 1 0.02 0.64 2.89
46 INT264929 Binding of Cnr1 and Gnaz 1 0.18 1.71 2.89
47 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85
48 INT351349 Prkcg Positive_regulation of Binding of Lpar1 1 0.15 2 2.82
49 INT170367 Binding of Grin1 and Grin2a 5 0.23 1.72 2.79
50 INT23280 PRSS1 Positive_regulation of Penk 1 0.05 1.53 2.74
51 INT140347 Binding of ATP1A2 and Cacna1a 1 0.11 2.88 2.73
52 INT349589 Aap Positive_regulation of Cyp2e1 1 0.21 1.84 2.71
53 INT318474 Positive_regulation of OPRM1 Positive_regulation of Localization of CA2 1 0.17 0.55 2.7
54 INT91350 Binding of Pla2g4a and RYBP 1 0.00 1.15 2.65
55 INT124547 Trib3 Regulation of Regulation of Th 1 0.02 0.79 2.64
56 INT167769 Prkca Positive_regulation of Positive_regulation of Sigmar1 1 0.38 0.86 2.63
57 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62
58 INT121742 Prkcg Positive_regulation of Ephb1 3 0.49 0.99 2.6
59 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54
60 INT26892 OGG1 Negative_regulation of Gene_expression of Gh1 1 0.12 0 2.53
61 INT20411 Ghrh Positive_regulation of Gh1 6 0.56 0.62 2.47
62 INT92182 Mir702 Negative_regulation of Adk 1 0.07 1.29 2.47
63 INT170038 Gtf3a Regulation of Gene_expression of DRGX 1 0.00 1.36 2.46
64 INT231968 Binding of Cpn1 and Rvm 1 0.11 1.57 2.45
65 INT231970 Binding of Cpn1 and Pag1 1 0.07 1.56 2.44
66 INT135867 Zfp821 Positive_regulation of Positive_regulation of Chrne 1 0.01 0 2.44
67 INT147659 Prkce Positive_regulation of TRPV1 1 0.04 1.42 2.43
68 INT251147 Binding of Grin2b and Dlg2 1 0.33 2.75 2.43
69 INT255317 Binding of Dpep1 and Nav1 1 0.01 0 2.42
70 INT56726 Cpe Negative_regulation of Pomc 1 0.07 0 2.41
71 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37
72 INT153728 RYBP Positive_regulation of Gpt 3 0.03 2.01 2.36
73 INT107578 Kitl Negative_regulation of Grin2b 1 0.12 2.05 2.36
74 INT247601 Binding of PEPD and SCN9A 1 0.15 2.26 2.27
75 INT231971 Binding of Cpn1 and Shbdp1 1 0.04 1.39 2.26
76 INT7367 Ghrh Regulation of Localization of Gh1 5 0.49 1.55 2.25
77 INT231967 Binding of Psmd1 and Cpn1 1 0.06 1.39 2.25
78 INT231969 Binding of Cfp and Cpn1 1 0.05 1.38 2.25
79 INT312690 CP Positive_regulation of CCL20 1 0.11 8.23 2.2
80 INT155984 Il1a Negative_regulation of Gene_expression of Cyp3a11 1 0.24 0.92 2.2
81 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19
82 INT334136 Binding of IFNA1 and Acsm3 1 0.01 4.52 2.19
83 INT9180 Ghrh Regulation of Localization of Gh 3 0.24 0.25 2.18
84 INT209924 IL1B Negative_regulation of PPARA 1 0.20 4.38 2.17
85 INT255318 Binding of Dpep1 and Nrcam 1 0.00 0 2.16
86 INT39108 Binding of PDYN and YY1 2 0.50 0.44 2.14
87 INT3576 Sst Negative_regulation of Localization of Gh1 6 0.23 0 2.13
88 INT319581 Binding of PIAS1 and TNFSF14 1 0.02 1.58 2.13
89 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13
90 INT318473 Positive_regulation of OPRM1 Positive_regulation of CA2 1 0.17 0.46 2.13
91 INT66157 Binding of ALB and BDP1 1 0.11 0 2.13
92 INT135868 Zfp821 Positive_regulation of Binding of ACAA1 1 0.00 0 2.11
93 INT251145 Binding of Grin2a and Dlg2 1 0.31 2.3 2.11
94 INT77807 Edn1 Positive_regulation of Gene_expression of Ptgs2 1 0.33 0.53 2.1
95 INT79470 Mgat4a Regulation of Localization of Calca 1 0.08 1.72 2.1
96 INT63919 Binding of Cck and Insrr 1 0.01 0 2.08
97 INT296277 Binding of Car2 and Kcnip3 5 0.18 1.09 2.06
98 INT121216 Prkca Regulation of Positive_regulation of Oprd1 1 0.02 0.32 2.02
99 INT144115 Positive_regulation of Grm5 Positive_regulation of Prkcg 1 0.41 0 2.01
100 INT334532 Sema3a Negative_regulation of Gene_expression of Nrp1 1 0.19 7.58 2
101 INT26948 Pomc Positive_regulation of Localization of Gh1 2 0.22 0.15 1.99
102 INT274372 Phc1 Negative_regulation of Slc6a3 1 0.06 0.47 1.99
103 INT54488 Npepo Regulation of Gene_expression of Jun 1 0.30 0 1.98
104 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 0.14 0.89 1.98
105 INT163266 Crh Negative_regulation of Tyr 1 0.01 0.45 1.98
106 INT164665 Adarb1 Positive_regulation of Negative_regulation of Tens1 1 0.03 0.42 1.97
107 INT129212 RYBP Positive_regulation of Tnf 2 0.03 1.9 1.95
108 INT69556 Slc7a11 Regulation of Cpe 2 0.06 0.46 1.95
109 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94
110 INT60867 Binding of G2e3 and Gpm6a 2 0.01 0.1 1.93
111 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93
112 INT227493 Binding of TCEA1 and SIRT2 1 0.01 1.55 1.93
113 INT116815 Binding of Pias1 and Ppbp 1 0.36 0.86 1.92
114 INT14991 SFTPA1 Positive_regulation of Localization of MPO 1 0.11 1.65 1.92
115 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91
116 INT30146 Binding of Adarb1 and Pdyn 1 0.01 0.17 1.91
117 INT186435 Prkcg Regulation of Creb1 1 0.44 0.45 1.9
118 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9
119 INT129903 Nr1i2 Regulation of Cyp3a11 1 0.64 1.26 1.9
120 INT135582 Prok2 Positive_regulation of Localization of Prkce 1 0.06 1.02 1.87
121 INT243043 Binding of Mmp9 and Timp1 1 0.05 0.25 1.86
122 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85
123 INT349658 Nos2 Regulation of Gene_expression of Nos1 1 0.63 2.86 1.84
124 INT275851 PES1 Negative_regulation of CP 1 0.01 1.96 1.83
125 INT16891 GHRH Regulation of GH1 5 0.37 1.94 1.82
126 INT168010 Asap1 Positive_regulation of HBG2 1 0.01 3.03 1.82
127 INT276669 Negative_regulation of Prkcg Regulation of Nav1 1 0.21 0.68 1.82
128 INT120732 Prkcg Positive_regulation of Phosphorylation of Grin1 2 0.48 1.04 1.81
129 INT192161 Mmp14 Positive_regulation of Mmp2 2 0.19 1.23 1.81
130 INT99138 Coq10a Regulation of Insrr 1 0.01 0.73 1.81
131 INT272616 Positive_regulation of Binding of Grin1 and Grin2a 2 0.30 1.36 1.8
132 INT121218 Arrb2 Regulation of Negative_regulation of Prkca 1 0.17 0.23 1.8
133 INT162992 Binding of Ephb1 and Ppm1e 1 0.03 0.25 1.77
134 INT167320 Binding of CPE and OPRM1 1 0.14 0.63 1.77
135 INT102160 Binding of Mmp2 and Mmp9 3 0.28 2.87 1.75
136 INT142899 Chn1 Negative_regulation of Positive_regulation of NOS1 1 0.01 1.07 1.75
137 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75
138 INT167765 Prkca Positive_regulation of Sigmar1 1 0.41 0.63 1.74
139 INT86997 Binding of HIVEP1 and NGF 2 0.03 1.75 1.73
140 INT37840 Binding of Cyp27b1 and Oprd1 1 0.01 0 1.73
141 INT92369 Binding of CYP2D6 and RYBP 1 0.25 0.15 1.73
142 INT346217 Braf Positive_regulation of Phosphorylation of Map2k1 1 0.22 3.23 1.72
143 INT282398 Binding of Mefv and Nlrp3 1 0.40 6.8 1.72
144 INT94203 SP5 Positive_regulation of FOS 1 0.25 1.41 1.72
145 INT175986 Ros1 Positive_regulation of Gtf3a 2 0.01 4.75 1.71
146 INT296280 Binding of Car2 and Dlg4 1 0.19 0.45 1.71
147 INT119413 SEMA6A Positive_regulation of TNFRSF11A 1 0.10 2.48 1.7
148 INT200335 Binding of Oprm1 and Rest 1 0.40 0.07 1.7
149 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7
150 INT62065 Binding of YY1 and Penk 3 0.14 0 1.69
151 INT266391 Binding of Ager and S100a1 1 0.01 5.63 1.69
152 INT30134 Binding of TPP1 and S100A9 1 0.13 0.74 1.69
153 INT213071 IL6 Positive_regulation of Gene_expression of CRP 4 0.52 6.58 1.68
154 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67
155 INT150232 Samhd1 Positive_regulation of Gene_expression of TNFSF13B 1 0.01 1.74 1.67
156 INT276672 Binding of Prkcg and Nav1 1 0.16 0.18 1.67
157 INT139433 Binding of Prkaca and Prkca 1 0.37 0.13 1.67
158 INT276680 Binding of Prkcg and Nkx1-1 1 0.05 0.18 1.66
159 INT122428 Binding of Ighm and Prkci 1 0.00 0 1.66
160 INT151889 Binding of Adarb1 and DLL1 1 0.00 0 1.66
161 INT347396 RYBP Positive_regulation of Binding of Sdcbp 1 0.00 0.92 1.66
162 INT93470 Notch1 Positive_regulation of Localization of Prkcg 2 0.09 0.31 1.65
163 INT278223 Binding of NOS3 and ACSM3 1 0.41 6.32 1.65
164 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
165 INT45816 Binding of Car2 and Gabrg1 2 0.28 0.15 1.63
166 INT67966 Cck Positive_regulation of Adarb1 2 0.03 0 1.63
167 INT54484 Npepo Positive_regulation of Gene_expression of Fos 1 0.43 0 1.63
168 INT135516 PRKCA Negative_regulation of Phosphorylation of OPRM1 1 0.12 0 1.62
169 INT168612 Negative_regulation of Nos1 Negative_regulation of Positive_regulation of Mmp9 1 0.23 0.45 1.62
170 INT109525 Binding of DMRT1 and Oprm1 1 0.08 0 1.62
171 INT107965 Binding of HLA-B and Mefv 2 0.34 3.91 1.61
172 INT168607 Negative_regulation of Nos1 Negative_regulation of Mmp9 1 0.23 0.45 1.61
173 INT94033 Binding of Adarb1 and SLAMF6 1 0.01 0 1.61
174 INT63939 Vta1 Positive_regulation of Th 1 0.14 0 1.61
175 INT73116 TYMS Negative_regulation of DNMT3B 1 0.24 0 1.6
176 INT90929 Binding of Ap1m1 and Insrr 1 0.01 0.19 1.6
177 INT167200 Gtf3a Regulation of Gene_expression of Ngf 1 0.08 1.47 1.6
178 INT109739 Binding of ITPA and Pcyt1b 1 0.16 0.72 1.6
179 INT73115 TYMS Negative_regulation of Positive_regulation of DNMT3B 1 0.24 0 1.6
180 INT326509 Binding of ACE and VWF 1 0.05 2.07 1.59
181 INT342993 PHEX Regulation of Protein_catabolism of SFTPA1 1 0.00 2.84 1.58
182 INT40827 Sstr1 Negative_regulation of Localization of Gh1 1 0.13 0 1.58
183 INT118515 Positive_regulation of PRKCA Positive_regulation of Phosphorylation of TRPV1 1 0.27 0.56 1.58
184 INT168609 Binding of Itgb1 and Mmp9 1 0.02 0.41 1.58
185 INT128512 Regulation of Pnoc Regulation of Adarb1 1 0.01 0.46 1.58
186 INT168611 Binding of Mmp9 and Ndor1 1 0.29 0.41 1.57
187 INT26985 Cpe Negative_regulation of Localization of Ins1 1 0.02 0 1.57
188 INT212660 Nr3c1 Regulation of KCNA1 1 0.00 1.25 1.57
189 INT168608 Binding of Grin2b and Mmp9 1 0.22 0.41 1.57
190 INT347397 RYBP Positive_regulation of Sdcbp 1 0.00 0.22 1.56
191 INT76651 Cpe Positive_regulation of Gene_expression of Il6 1 0.08 0 1.56
192 INT315284 PRKG1 Positive_regulation of Nos1 1 0.33 0.85 1.56
193 INT208991 Binding of CALM1 and Ca2 10 0.06 1.34 1.55
194 INT208980 Binding of Ca2 and Trpv1 4 0.32 0.67 1.55
195 INT276671 Prkcg Positive_regulation of Nav1 1 0.23 0.21 1.55
196 INT249498 Src Positive_regulation of Phosphorylation of Grin2b 1 0.22 1.11 1.54
197 INT100784 RYBP Positive_regulation of CYP3A4 1 0.44 0 1.54
198 INT284785 Gch1 Regulation of Bh4p 1 0.00 1.48 1.54
199 INT40887 Penk Regulation of Th 1 0.04 0 1.53
200 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53

Single Events

The table below shows the top 100 pain related interactions that have been reported for metal ion binding. They are ordered first by their pain relevance and then by number of times they were reported in metal ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26
2 INT876 Localization of Gh1 843 0.80 67.75 340.82
3 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85
4 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41
5 INT1893 Localization of Gh 1041 0.79 340.23 256.58
6 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6
7 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47
8 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18
9 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07
10 INT4740 Gene_expression of Th 298 0.78 61.27 154.03
11 INT880 Positive_regulation of Localization of Gh1 304 0.70 14.79 150.23
12 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64
13 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9
14 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91
15 INT115386 Gene_expression of Ppara 779 0.77 549.99 128.36
16 INT252 Localization of GH1 529 0.80 227.4 122.05
17 INT218 Positive_regulation of Th 245 0.70 40.5 120.1
18 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03
19 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92
20 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51
21 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85
22 INT48593 Positive_regulation of NOS1 420 0.68 226.15 114.71
23 INT1530 Regulation of Gh 382 0.61 115.96 112.47
24 INT7327 Regulation of Th 164 0.62 29.67 110.14
25 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58
26 INT47243 Gene_expression of Prkcg 195 0.78 58.05 108.44
27 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76
28 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74
29 INT65500 Gene_expression of App 605 0.78 429.94 98.31
30 INT874 Positive_regulation of Gh1 244 0.70 27.17 97.98
31 INT4822 Localization of Ca2 417 0.80 99.57 96.45
32 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97
33 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71
34 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35
35 INT5865 Positive_regulation of Localization of Gh 282 0.69 84.86 93.5
36 INT104000 Phosphorylation of Grin2b 73 0.82 48.34 93.48
37 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43
38 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14
39 INT6437 Binding of YY1 154 0.47 26.3 90.46
40 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32
41 INT6585 Positive_regulation of Insrr 110 0.52 40.67 89.9
42 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63
43 INT6214 Negative_regulation of Adarb1 123 0.50 26.39 89.57
44 INT64158 Negative_regulation of Prkca 121 0.59 29.8 88.66
45 INT22967 Positive_regulation of RYBP 94 0.56 37.04 85.92
46 INT875 Regulation of Localization of Gh1 166 0.62 12.87 84.97
47 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91
48 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71
49 INT84546 Positive_regulation of Ppara 481 0.70 334.21 83.45
50 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16
51 INT92518 Gene_expression of Grin2b 131 0.78 65.52 80.91
52 INT920 Localization of PLOD1 223 0.81 42.25 78.7
53 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68
54 INT881 Negative_regulation of Localization of Gh1 164 0.58 15.1 75.28
55 INT1497 Negative_regulation of Gh 415 0.59 192.95 74.71
56 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48
57 INT12536 Localization of Prkcg 101 0.80 36.37 73.81
58 INT79506 Gene_expression of Grin2b 122 0.78 43.71 73.42
59 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16
60 INT4153 Binding of Insrr 109 0.40 17.99 72.15
61 INT8962 Gene_expression of Cpe 110 0.71 39.67 71.67
62 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96
63 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91
64 INT39777 Regulation of Prkcg 90 0.62 31.52 68.17
65 INT5861 Gene_expression of Egr1 203 0.78 49.35 68.13
66 INT4637 Binding of Adarb1 132 0.41 14.48 67.76
67 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34
68 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08
69 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01
70 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9
71 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64
72 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61
73 INT217 Negative_regulation of Th 134 0.59 26.83 62.63
74 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89
75 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6
76 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5
77 INT546 Binding of ALB 311 0.48 85.98 60.14
78 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61
79 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45
80 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29
81 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87
82 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81
83 INT18883 Negative_regulation of RYBP 53 0.56 21.14 57.52
84 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35
85 INT96937 Gene_expression of Mmp9 191 0.75 150.3 56.01
86 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97
87 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94
88 INT1782 Regulation of Gh1 125 0.62 22 55.74
89 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73
90 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08
91 INT48642 Positive_regulation of TCEA1 92 0.70 24.59 53.64
92 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04
93 INT1032 Regulation of Ca2 202 0.52 54.91 53.03
94 INT1487 Regulation of Cpe 68 0.62 10.24 52.91
95 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71
96 INT1781 Negative_regulation of Gh1 127 0.59 16.94 51.77
97 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64
98 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57
99 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51
100 INT122041 Binding of Ppara 308 0.48 189.17 51.48
101 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22
102 INT49028 Positive_regulation of Nos1 102 0.70 34.73 51.05
103 INT921 Regulation of GH1 172 0.60 52.88 51.04
104 INT6165 Gene_expression of Adarb1 85 0.58 18.39 51.03
105 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39
106 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47
107 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39
108 INT12471 Regulation of Insrr 52 0.35 17.8 48.31
109 INT51627 Gene_expression of Grin2a 82 0.76 25.09 47.6
110 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06
111 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9
112 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76
113 INT873 Gene_expression of Gh1 130 0.76 26.15 46.75
114 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49
115 INT531 Gene_expression of GH1 376 0.75 193.45 46.24
116 INT4656 Localization of RYBP 49 0.77 5.28 46.21
117 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97
118 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81
119 INT17561 Localization of Car2 303 0.79 60.95 44.52
120 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41
121 INT5214 Localization of Cpe 49 0.73 13.3 44.36
122 INT1894 Negative_regulation of Localization of Gh 168 0.58 64.12 43.56
123 INT935 Localization of Gtf3a 124 0.70 35.72 43.3
124 INT115384 Positive_regulation of Mmp9 121 0.68 94.74 43.02
125 INT613 Gene_expression of Alb 268 0.78 149.84 42.78
126 INT85943 Negative_regulation of Nos2 161 0.59 108.56 42.65
127 INT11180 Binding of RYBP 52 0.46 13.86 42.53
128 INT94029 Positive_regulation of Grin2b 58 0.70 24.2 42.52
129 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03
130 INT5539 Negative_regulation of Mme 75 0.59 28.91 41.84
131 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56
132 INT350 Localization of Th 79 0.80 10.26 41.17
133 INT57442 Phosphorylation of Prkca 98 0.70 31.58 41.04
134 INT61925 Negative_regulation of Adk 53 0.59 22.46 40.38
135 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33
136 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94
137 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75
138 INT68975 Gene_expression of Mmp9 111 0.78 79.57 38.55
139 INT55135 Positive_regulation of Gene_expression of PTGS2 137 0.70 80.32 38.46
140 INT92515 Gene_expression of Grin2a 84 0.76 26.68 38.37
141 INT30817 Gene_expression of Th 142 0.76 33.56 38.12
142 INT18774 Gene_expression of RYBP 67 0.65 47.66 37.59
143 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53
144 INT82054 Positive_regulation of Grin2b 56 0.70 17.45 37.14
145 INT64558 Negative_regulation of Nos1 88 0.58 26.76 36.78
146 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69
147 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54
148 INT48959 Positive_regulation of Positive_regulation of Prkcg 52 0.70 16.47 36.49
149 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45
150 INT12029 Gene_expression of Car1 143 0.67 29.69 36.39
151 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23
152 INT103998 Positive_regulation of Phosphorylation of Grin2b 33 0.69 19.08 36.08
153 INT11292 Gene_expression of Mme 77 0.78 20.98 35.85
154 INT7326 Transcription of Th 83 0.72 13.5 35.33
155 INT255 Regulation of Localization of GH1 89 0.62 18.71 35.3
156 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27
157 INT130479 Phosphorylation of Grin2b 28 0.77 34.82 34.97
158 INT79060 Gene_expression of NOS2 116 0.78 69.25 34.84
159 INT103094 Binding of PPARA 308 0.47 177.26 34.75
160 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67
161 INT67613 Positive_regulation of PPARG 94 0.70 69.15 34.38
162 INT223416 Gene_expression of Trhde 2 0.48 64.16 34.21
163 INT16960 Gene_expression of Crp 166 0.76 116.21 34.07
164 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96
165 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83
166 INT12537 Positive_regulation of Localization of Prkcg 36 0.70 14.57 33.81
167 INT2699 Binding of Cpe 40 0.48 7.07 33.64
168 INT5489 Localization of CA2 172 0.80 39.46 33.56
169 INT7133 Negative_regulation of MME 85 0.59 29.22 33.1
170 INT234 Binding of Alb 151 0.48 52.34 32.97
171 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92
172 INT51698 Positive_regulation of Gene_expression of Prkcg 44 0.68 14.02 32.9
173 INT913 Regulation of Localization of PLOD1 71 0.62 8.64 32.72
174 INT99610 Localization of MMP9 126 0.79 48.46 32.67
175 INT20307 Positive_regulation of Cyp2e1 70 0.70 23.59 32.49
176 INT985 Negative_regulation of GH1 213 0.57 89.53 32.39
177 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17
178 INT93451 Positive_regulation of Gene_expression of Grin2b 43 0.70 29.09 31.89
179 INT92837 Negative_regulation of Gene_expression of Nos2 116 0.59 59.67 31.82
180 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68
181 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
182 INT86780 Positive_regulation of Hmox1 145 0.70 117.09 31.18
183 INT5418 Negative_regulation of Alox5 108 0.57 42.09 31.17
184 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16
185 INT64164 Regulation of Prkca 34 0.62 10.44 30.99
186 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89
187 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51
188 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46
189 INT9133 Negative_regulation of Positive_regulation of Prkcg 37 0.59 10.95 30.06
190 INT68973 Positive_regulation of Mmp9 89 0.52 58.56 30.04
191 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02
192 INT12502 Regulation of Adarb1 50 0.53 7.58 30.01
193 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94
194 INT64113 Positive_regulation of Gene_expression of NOS1 110 0.60 71.03 29.72
195 INT724 Negative_regulation of Alb 151 0.59 93.57 29.65
196 INT7956 Regulation of Gene_expression of Th 44 0.61 8.26 29.31
197 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18
198 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95
199 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
200 INT28361 Gene_expression of TP53 443 0.78 384.86 28.8
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