GO:0046914

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Name transition metal ion binding
Categary Function
Go Slim No
Go Link GO:0046914
Unique Molecular Interactions 162
Total Molecular Interactions 245
Total Single Events 2581
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for transition metal ion binding. They are ordered first by their pain relevance and then by number of times they were reported for transition metal ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT191618 Binding of App and Nf1 1 0.35 3.77 1.65
2 INT266406 Binding of APP and Ager 1 0.00 2.34 1.57
3 INT120205 Binding of App and Ern1 1 0.05 2.55 1.18
4 INT168529 APP Regulation of FSIP1 2 0.65 2.26 1.07
5 INT250085 Coq7 Positive_regulation of Ltp 1 0.00 0.52 1
6 INT159996 Prkcg Regulation of Gene_expression of App 1 0.42 0.32 0.92
7 INT159993 App Regulation of Gene_expression of Bace1 1 0.46 0.32 0.92
8 INT159994 App Regulation of Gene_expression of Prkcg 1 0.42 0.32 0.92
9 INT167431 Binding of APP and MYO1C 1 0.23 1.38 0.83
10 INT193279 Phax Regulation of Fth1 1 0.01 0.16 0.81
11 INT107917 RETNLB Positive_regulation of Gene_expression of App 1 0.01 1.2 0.79
12 INT99818 IFNG Positive_regulation of Gene_expression of APP 1 0.04 0.82 0.7
13 INT2700 Binding of App and Cpe 1 0.00 0 0.63
14 INT333544 CTSB Regulation of Protein_catabolism of APP 1 0.01 0.53 0.62
15 INT118083 Aip Negative_regulation of Phosphorylation of APP 1 0.00 0.75 0.62
16 INT333543 CTSB Regulation of APP 1 0.01 0.53 0.62
17 INT84771 Positive_regulation of Binding of App and Pag1 1 0.17 0.9 0.62
18 INT193290 CAP1 Regulation of Fth1 1 0.02 0 0.6
19 INT120203 Binding of App and Il1 1 0.17 1.28 0.59
20 INT120204 Binding of App and Il1f5 1 0.09 1.28 0.59
21 INT84770 Binding of App and Pag1 1 0.13 0.89 0.57
22 INT167618 Rho Regulation of App 1 0.17 0.88 0.55
23 INT167620 Rock2 Regulation of App 1 0.13 0.87 0.55
24 INT118082 APP Positive_regulation of Casp3 1 0.00 0.5 0.54
25 INT204494 Binding of App and Fmr1 1 0.54 4.39 0.54
26 INT145260 Binding of CLU and App 1 0.00 0.74 0.46
27 INT167621 Psenen Positive_regulation of App 1 0.02 0.86 0.44
28 INT167617 Bace2 Positive_regulation of App 1 0.06 0.87 0.44
29 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 0.00 0.88 0.44
30 INT191610 Binding of App and Drd3 1 0.20 0.7 0.42
31 INT247599 Tlr4 Positive_regulation of Gene_expression of App 1 0.17 0.39 0.42
32 INT139873 Negative_regulation of CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
33 INT139874 CTSB Negative_regulation of Gene_expression of App 1 0.00 0.8 0.41
34 INT79577 APP Negative_regulation of PENK 1 0.12 0.35 0.4
35 INT78121 Positive_regulation of Binding of App and 20S 1 0.23 0.61 0.4
36 INT78122 Binding of App and 20S 1 0.16 0.61 0.4
37 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39
38 INT323967 Il6 Positive_regulation of Gene_expression of App 1 0.10 0.86 0.38
39 INT78854 APP Positive_regulation of Localization of IL6 1 0.14 0.79 0.37
40 INT134168 Binding of ADRA2B and APLP1 1 0.06 0.7 0.37
41 INT124376 Prodh2 Positive_regulation of App 1 0.00 0.66 0.33
42 INT124379 Prodh2 Positive_regulation of Localization of App 1 0.00 0.66 0.33
43 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 0.04 1.14 0.32
44 INT147434 Psenen Positive_regulation of APP 1 0.01 0.58 0.32
45 INT68977 App Positive_regulation of Localization of Mmp9 1 0.05 0.38 0.3
46 INT135095 Negative_regulation of CTSB Negative_regulation of APP 1 0.00 0.74 0.3
47 INT319220 FSIP1 Regulation of APP 1 0.29 1.46 0.29
48 INT79592 Binding of APP and Reg1 1 0.01 0.16 0.27
49 INT25946 Regulation of Binding of Penk and App 1 0.18 0.19 0.27
50 INT25944 Binding of Penk and App 1 0.15 0.19 0.27
51 INT356094 Binding of App and Tg 1 0.08 0.12 0.26
52 INT139980 Negative_regulation of CTSB Negative_regulation of Gene_expression of APP 1 0.15 0.7 0.26
53 INT139981 CTSB Negative_regulation of Gene_expression of APP 1 0.11 0.7 0.26
54 INT39010 App Negative_regulation of Gene_expression of Gnrh1 1 0.05 0.07 0.26
55 INT114244 Cpox Negative_regulation of Gene_expression of APP 1 0.00 0.7 0.25
56 INT191619 Binding of App and Flna 1 0.04 0.18 0.24
57 INT70082 Binding of APP and TGM1 1 0.00 1.22 0.22
58 INT319971 App Regulation of Enpp1 1 0.02 0.72 0.21
59 INT146687 Regulation of Binding of App and Aph1a 1 0.16 0.58 0.19
60 INT146686 Binding of App and Aph1a 1 0.14 0.58 0.19
61 INT25945 Plat Regulation of App 1 0.15 0.25 0.17
62 INT25947 Plat Regulation of Transcription of App 1 0.15 0.25 0.17
63 INT319974 App Negative_regulation of Enpp1 1 0.02 0.58 0.16
64 INT204478 Fmr1 Regulation of Gene_expression of App 1 0.50 1.44 0.16
65 INT201744 Ngf Regulation of Transcription of App 1 0.06 0.39 0.15
66 INT201728 Ntrk1 Regulation of Transcription of App 1 0.03 0.39 0.15
67 INT319972 App Negative_regulation of Gene_expression of Enpp1 1 0.02 1.87 0.15
68 INT286476 Binding of App and Itm2b 1 0.47 5.24 0.14
69 INT94763 PSEN2 Regulation of Positive_regulation of App 1 0.11 0.72 0.14
70 INT139849 Binding of App and Bace1 7 0.41 0.85 0.13
71 INT204489 Fmr1 Regulation of App 1 0.50 1.71 0.13
72 INT220622 App Positive_regulation of Rip 2 0.14 0.24 0.12
73 INT308660 Binding of Ager and App 1 0.08 1.22 0.12
74 INT70084 Negative_regulation of Binding of APP and TGM1 1 0.00 0.61 0.11
75 INT70083 TGM1 Positive_regulation of Binding of APP 1 0.00 0.61 0.11
76 INT123101 Binding of APP and Ache 1 0.07 0.32 0.11
77 INT84867 Ptger1 Negative_regulation of SETD2 1 0.00 1.09 0.11
78 INT204477 Binding of App and Scn10a 1 0.17 0.36 0.1
79 INT139847 Binding of App and Bace2 1 0.03 0.16 0.1
80 INT139850 Binding of MBTPS1 and App 1 0.00 0.16 0.1
81 INT193963 App Regulation of Gene_expression of Ps 1 0.06 0.93 0.09
82 INT356112 Binding of App and Apba1 1 0.24 0.29 0.09
83 INT262702 Bace1 Positive_regulation of Aplp2 1 0.14 0.25 0.09
84 INT262701 App Positive_regulation of Aplp2 1 0.12 0.25 0.09
85 INT262705 App Positive_regulation of Aplp1 1 0.13 0.25 0.09
86 INT124036 Binding of App and Dnahc8 1 0.03 0.14 0.09
87 INT262704 Bace1 Positive_regulation of Aplp1 1 0.15 0.25 0.09
88 INT205135 Binding of APOE and APP 1 0.05 0.35 0.08
89 INT193959 Psen1 Regulation of App 1 0.40 0.58 0.08
90 INT204487 Positive_regulation of Fmr1 Regulation of Gene_expression of App 1 0.30 0.8 0.08
91 INT107727 ASIP Negative_regulation of RRM2 1 0.29 0.43 0.07
92 INT193954 Binding of App and Psen1 3 0.38 0.88 0.06
93 INT198934 Binding of App and Lrp1b 2 0.27 1.62 0.05
94 INT288099 Binding of APP and App 1 0.01 1.04 0.05
95 INT356086 Negative_regulation of Binding of App and Lrp1b 1 0.30 1.42 0.05
96 INT356110 Binding of App and Slc5a7 1 0.02 0.25 0.05
97 INT236009 HIST2H2AA3 Positive_regulation of Protein_catabolism of APP 1 0.02 0.19 0.04
98 INT236015 HIST2H2AA3 Positive_regulation of Gene_expression of APP 1 0.02 0.95 0.04
99 INT162753 Binding of APP and Slc30a2 1 0.00 1.25 0.04
100 INT319973 App Regulation of Gene_expression of Mapk12 1 0.02 0.98 0.04
101 INT162754 Negative_regulation of Binding of APP and Slc30a2 1 0.00 1.26 0.04
102 INT356101 App Regulation of Negative_regulation of Psen1 1 0.23 0.31 0.04
103 INT198921 Binding of App and Lrp1 3 0.32 2.7 0.03
104 INT356102 Negative_regulation of Binding of App and Lrp1 1 0.32 0.71 0.03
105 INT237090 Binding of App and Bnip3l 1 0.18 1.66 0.03
106 INT230137 OSBP Regulation of APP 1 0.59 0.15 0.03
107 INT356097 Binding of App and Apba3 1 0.12 0.12 0.03
108 INT270432 Lhb Positive_regulation of APP 1 0.03 0.51 0.03
109 INT356090 Binding of Apba2 and App 1 0.00 0.12 0.03
110 INT270431 Gnrh1 Positive_regulation of APP 1 0.06 0.51 0.03
111 INT220628 Gene_expression of Gga1 Positive_regulation of App 2 0.22 0 0
112 INT329641 Rrm2 Regulation of Ear11 1 0.01 0.49 0
113 INT220625 Negative_regulation of Binding of App and Bace1 1 0.44 0.09 0
114 INT329642 Rrm2 Regulation of Eefsec 1 0.04 0.42 0
115 INT356108 App Positive_regulation of Positive_regulation of Lrp1 1 0.43 0.52 0
116 INT333770 Bace1 Regulation of Gene_expression of App 1 0.57 0 0
117 INT204493 App Negative_regulation of Scn10a 1 0.20 0.74 0
118 INT329649 Binding of VEGFA and Rrm2 1 0.02 2.39 0
119 INT236013 HIST2H2AA3 Regulation of Gene_expression of APP 1 0.01 0 0
120 INT204499 App Regulation of Fmr1 1 0.50 0.59 0
121 INT204492 Negative_regulation of Binding of App and Fmr1 1 0.42 0.28 0
122 INT356083 Binding of App and Notch1 1 0.02 0.2 0
123 INT322607 Binding of RRM2 and TF 1 0.02 0.09 0
124 INT356095 Lrp1 Positive_regulation of App 1 0.37 0.53 0
125 INT204502 Binding of App and RNPC3 1 0.01 0.09 0
126 INT356091 Lrp1 Positive_regulation of Positive_regulation of App 1 0.43 0.52 0
127 INT204481 App Negative_regulation of Positive_regulation of Scn10a 1 0.20 0.74 0
128 INT356100 Binding of Apbb1 and App 1 0.14 0.43 0
129 INT356087 Binding of App and Ncstn 1 0.17 0.07 0
130 INT230140 Gene_expression of OSBP Regulation of Localization of APP 1 0.30 0.06 0
131 INT198933 Binding of Apoe and App 1 0.33 0.19 0
132 INT198927 Lrp1 Regulation of App 1 0.14 0.42 0
133 INT204482 Fmr1 Negative_regulation of App 1 0.42 0.74 0
134 INT334643 Binding of APP and HM13 1 0.02 0 0
135 INT356118 Binding of SORL1 and App 1 0.41 0.43 0
136 INT230146 Binding of APP and SORL1 1 0.20 0.17 0
137 INT356109 Rab6a Regulation of App 1 0.14 0.05 0
138 INT180123 Egfl7 Positive_regulation of App 1 0.02 0.07 0
139 INT356106 Gene_expression of Pld1 Positive_regulation of App 1 0.29 0.21 0
140 INT225629 APP Positive_regulation of Positive_regulation of nr 1 0.01 0.08 0
141 INT217396 Binding of Abca1 and App 1 0.26 0.83 0
142 INT262708 Bace1 Positive_regulation of Gene_expression of App 1 0.44 2.82 0
143 INT198915 Binding of App and Lrp8 1 0.24 0.17 0
144 INT230139 OSBP Regulation of Phosphorylation of APP 1 0.50 0 0
145 INT142955 Positive_regulation of Binding of APP and BACE1 1 0.48 0.5 0
146 INT262713 App Regulation of Transcription of Bace1 1 0.45 0.31 0
147 INT198925 Binding of App and Ldlr 1 0.14 0.15 0
148 INT333773 Bace1 Regulation of App 1 0.25 0 0
149 INT230143 OSBP Regulation of Gene_expression of APP 1 0.50 0.1 0
150 INT142954 Binding of APP and BACE1 1 0.37 0.5 0
151 INT204491 Ass1 Positive_regulation of App 1 0.01 0.43 0
152 INT234221 Negative_regulation of PSEN1 Negative_regulation of Gene_expression of APP 1 0.33 0.32 0
153 INT50104 Bche Regulation of Localization of App 1 0.43 0.2 0
154 INT356104 Positive_regulation of Binding of App and Lrp1 1 0.40 0.52 0
155 INT230151 OSBP Regulation of Localization of APP 1 0.50 0 0
156 INT220624 Eif1 Regulation of App 1 0.00 0.1 0
157 INT204496 App Positive_regulation of Scn10a 1 0.20 0.48 0
158 INT225627 APP Positive_regulation of nr 1 0.02 0.08 0
159 INT230149 Binding of APP and NOTCH2 1 0.32 0.32 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for transition metal ion binding. They are ordered first by their pain relevance and then by number of times they were reported in transition metal ion binding. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT65500 Gene_expression of App 605 0.78 429.94 98.31
2 INT29743 Negative_regulation of App 91 0.59 65.56 31.26
3 INT47712 Positive_regulation of App 135 0.69 101.38 28.94
4 INT89662 Positive_regulation of Gene_expression of App 169 0.70 133.36 25.62
5 INT44954 Gene_expression of APP 191 0.78 105.86 23.9
6 INT11625 Localization of App 98 0.78 55.46 20.86
7 INT16794 Binding of App 103 0.48 64.87 19.79
8 INT65502 Regulation of App 77 0.62 52.05 19.44
9 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68
10 INT54052 Gene_expression of App 33 0.78 25.08 14.7
11 INT29745 Binding of APP 47 0.48 26.49 12.4
12 INT107916 Protein_catabolism of App 114 1.00 66.71 12.38
13 INT65501 Regulation of Gene_expression of App 56 0.62 32.51 11.48
14 INT98789 Negative_regulation of Gene_expression of App 54 0.58 40.27 11.15
15 INT41569 Regulation of APP 32 0.62 17.15 9.4
16 INT56031 Positive_regulation of App 25 0.69 13.46 7.37
17 INT84932 Negative_regulation of APP 29 0.57 28.45 7.2
18 INT107173 Phosphorylation of App 20 0.82 12.64 5.3
19 INT99823 Positive_regulation of Gene_expression of APP 31 0.70 21.52 5.09
20 INT115816 Protein_catabolism of APP 35 0.99 20.14 5.06
21 INT131692 Negative_regulation of Localization of App 9 0.53 4.69 4.82
22 INT78116 Positive_regulation of Gene_expression of App 12 0.70 10.78 4.52
23 INT58003 Localization of APP 32 0.80 13.75 4.2
24 INT99821 Negative_regulation of Gene_expression of APP 20 0.42 15.21 3.94
25 INT11627 Positive_regulation of Localization of App 14 0.62 6.27 3.64
26 INT99819 Negative_regulation of Positive_regulation of APP 6 0.58 4.41 3.64
27 INT70089 Negative_regulation of Binding of APP 7 0.59 6.45 3.44
28 INT108773 Negative_regulation of Binding of App 10 0.42 7.26 2.96
29 INT54055 Regulation of Gene_expression of App 7 0.62 4.04 2.93
30 INT77339 Positive_regulation of RRM2 5 0.41 1.36 2.88
31 INT178772 Transcription of App 17 0.70 10.79 2.79
32 INT147429 Negative_regulation of Positive_regulation of App 8 0.40 8.73 2.78
33 INT54054 Binding of App 4 0.48 10.89 2.78
34 INT162513 Regulation of Protein_catabolism of APP 5 0.51 1.79 2.36
35 INT11626 Regulation of Localization of App 4 0.45 1.51 2.34
36 INT56030 Regulation of App 8 0.62 4.06 2.32
37 INT124772 Regulation of Binding of App 6 0.45 4.92 2.09
38 INT39008 Localization of App 13 0.77 9.07 2.05
39 INT142774 Regulation of Phosphorylation of App 1 0.59 2.27 1.93
40 INT121117 Regulation of Protein_catabolism of App 10 0.62 6.41 1.78
41 INT107915 Regulation of Negative_regulation of App 6 0.45 4.47 1.76
42 INT133863 Positive_regulation of Protein_catabolism of App 12 0.59 7.53 1.52
43 INT58004 Positive_regulation of Localization of APP 5 0.46 2.1 1.5
44 INT25943 Transcription of App 5 0.53 1.79 1.44
45 INT125796 Regulation of Gene_expression of APP 8 0.59 5.95 1.41
46 INT129700 Regulation of Positive_regulation of App 3 0.43 1.86 1.41
47 INT141529 Regulation of Positive_regulation of APP 3 0.44 0.31 1.34
48 INT103488 Positive_regulation of Localization of App 5 0.50 3.05 1.28
49 INT100137 Positive_regulation of Negative_regulation of App 2 0.41 1.26 1.16
50 INT135899 Regulation of Binding of APP 3 0.45 1.22 1.14
51 INT39009 Negative_regulation of App 6 0.38 3.37 1.07
52 INT281849 Binding of RRM2 5 0.17 0.43 1.07
53 INT167607 Positive_regulation of Binding of App 8 0.50 2.97 0.86
54 INT162514 Positive_regulation of Regulation of APP 1 0.41 0.37 0.86
55 INT99375 Positive_regulation of Binding of APP 3 0.61 1.63 0.83
56 INT118078 Phosphorylation of APP 10 0.79 2.5 0.76
57 INT99820 Negative_regulation of Localization of APP 2 0.37 0.75 0.76
58 INT112208 Negative_regulation of Gene_expression of App 4 0.59 1.88 0.68
59 INT25942 Regulation of Transcription of App 3 0.27 0.95 0.68
60 INT134173 Binding of APLP1 4 0.37 2.41 0.67
61 INT141528 Regulation of Localization of APP 2 0.52 0.4 0.67
62 INT61147 Protein_catabolism of App 3 0.60 3.76 0.63
63 INT118077 Negative_regulation of Phosphorylation of APP 1 0.07 0.74 0.61
64 INT217091 Positive_regulation of Rrm2 5 0.33 4.12 0.6
65 INT142112 Regulation of Regulation of App 3 0.39 2.46 0.59
66 INT225462 Positive_regulation of Positive_regulation of APP 3 0.44 1.41 0.55
67 INT78117 Positive_regulation of Positive_regulation of App 4 0.48 2.6 0.51
68 INT77338 Negative_regulation of RRM2 2 0.38 0 0.49
69 INT217083 Gene_expression of Rrm2 10 0.47 4.16 0.47
70 INT167614 Positive_regulation of Protein_catabolism of App 1 0.30 0.88 0.44
71 INT54056 Negative_regulation of Binding of App 2 0.37 0.99 0.32
72 INT178773 Positive_regulation of Regulation of App 2 0.49 1.01 0.32
73 INT178774 Positive_regulation of Transcription of App 2 0.49 1.17 0.31
74 INT129470 Regulation of RRM2 4 0.22 0.36 0.27
75 INT134174 Gene_expression of APLP1 3 0.77 1.76 0.22
76 INT262690 Gene_expression of Aplp2 3 0.56 1.14 0.16
77 INT180104 Positive_regulation of Phosphorylation of App 2 0.54 0.87 0.16
78 INT286326 Regulation of Transcription of App 3 0.45 0.26 0.15
79 INT274773 Gene_expression of RRM2 1 0.08 0.21 0.15
80 INT262674 Gene_expression of Aplp1 2 0.54 0.7 0.13
81 INT69045 Negative_regulation of Positive_regulation of App 1 0.05 0.28 0.13
82 INT134170 Positive_regulation of APLP1 1 0.50 0.24 0.12
83 INT134172 Positive_regulation of Gene_expression of APLP1 1 0.50 0.26 0.12
84 INT142958 Positive_regulation of Protein_catabolism of APP 3 0.55 2.04 0.1
85 INT39007 Negative_regulation of Localization of App 3 0.10 0.94 0.08
86 INT262692 Positive_regulation of Gene_expression of Aplp1 1 0.31 0.24 0.08
87 INT262676 Positive_regulation of Gene_expression of Aplp2 1 0.29 0.24 0.08
88 INT157871 Negative_regulation of Gene_expression of Fth1 1 0.11 0.08 0.08
89 INT157874 Gene_expression of Fth1 1 0.16 0.07 0.07
90 INT193831 Localization of Aplp2 2 0.42 1.85 0.06
91 INT193837 Localization of Aplp1 2 0.45 1.85 0.06
92 INT193852 Positive_regulation of Localization of Aplp2 1 0.23 0.81 0.06
93 INT193853 Positive_regulation of Localization of Aplp1 1 0.25 0.81 0.06
94 INT188125 Binding of Aplp2 2 0.22 0.64 0.04
95 INT180116 Negative_regulation of Transcription of App 1 0.38 0 0.04
96 INT182830 Negative_regulation of Protein_catabolism of APP 2 0.35 2.09 0.03
97 INT217104 Negative_regulation of Rrm2 2 0.28 1.46 0.03
98 INT255657 Negative_regulation of Protein_catabolism of App 1 0.20 1.07 0.03
99 INT356071 Negative_regulation of Aplp1 1 0.37 0.44 0.03
100 INT351386 Negative_regulation of Phosphorylation of App 1 0.42 0.82 0.03
101 INT278278 Positive_regulation of Gene_expression of Rrm2 3 0.33 1.9 0
102 INT50103 Regulation of Localization of App 2 0.26 0.2 0
103 INT234255 Transcription of APP 2 0.49 0.98 0
104 INT217085 Binding of Rrm2 2 0.23 1.05 0
105 INT329627 Positive_regulation of Positive_regulation of Rrm2 1 0.24 0.57 0
106 INT286323 Negative_regulation of Protein_catabolism of App 1 0.11 0.54 0
107 INT329628 Positive_regulation of Negative_regulation of Rrm2 1 0.24 0.54 0
108 INT329626 Localization of Rrm2 1 0.39 0.72 0
109 INT236037 Positive_regulation of Phosphorylation of APP 1 0.48 0.14 0
110 INT220590 Binding of Aplp1 1 0.24 0.19 0
111 INT190556 Regulation of Aplp2 1 0.10 0.33 0
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