GO:0046931

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Name pore complex assembly
Categary Process
Go Slim No
Go Link GO:0046931
Unique Molecular Interactions 170
Total Molecular Interactions 210
Total Single Events 2036
Pain Genes Associated 6

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for pore complex assembly. They are ordered first by their pain relevance and then by number of times they were reported for pore complex assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT151779 Calca Positive_regulation of Transcription of P2rx7 1 0.02 0.54 0.87
2 INT215598 Positive_regulation of P2rx7 Positive_regulation of Localization of TNF 1 0.22 1.44 0.85
3 INT108331 EGF Positive_regulation of Phosphorylation of BAD 1 0.49 6.72 0.8
4 INT281241 Positive_regulation of P2RX7 Negative_regulation of Gene_expression of P2rx3 1 0.03 0.79 0.71
5 INT205706 P2rx7 Regulation of Gene_expression of Il18 1 0.21 1.35 0.7
6 INT246335 Fig4 Regulation of Localization of P2rx7 1 0.01 0 0.67
7 INT205702 P2rx7 Regulation of Gene_expression of Il1 1 0.04 1.38 0.67
8 INT205705 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of Il6 1 0.07 1.42 0.58
9 INT308174 Binding of TNF and P2rx7 1 0.02 0.84 0.56
10 INT282821 TACR1 Regulation of P2RX7 1 0.01 2.06 0.54
11 INT185490 Atp5o Negative_regulation of Gene_expression of P2rx7 1 0.01 0.87 0.53
12 INT216941 P2rx7 Regulation of Ryr1 1 0.01 0.55 0.52
13 INT278122 Negative_regulation of P2rx7 Negative_regulation of Binding of P2RX7 1 0.03 0 0.51
14 INT278105 Negative_regulation of TP63 Negative_regulation of Binding of P2RX7 1 0.00 0 0.51
15 INT5856 Bad Positive_regulation of Gene_expression of Penk 1 0.02 0.37 0.5
16 INT146276 Binding of P2RX4 and P2RX7 1 0.38 0.38 0.43
17 INT169859 P2rx7 Regulation of Gene_expression of Grin1 1 0.17 0 0.43
18 INT324813 Tlr4 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
19 INT324803 Hmgb1 Positive_regulation of Gene_expression of Bad 1 0.02 0.44 0.37
20 INT322015 Binding of IL1B and P2RX7 1 0.07 1 0.37
21 INT324827 Hmgb1 Positive_regulation of Bad 1 0.02 0.43 0.36
22 INT324808 Tlr4 Positive_regulation of Bad 1 0.02 0.43 0.36
23 INT205704 P2rx7 Regulation of Localization of Il18 1 0.09 0.67 0.35
24 INT191128 Positive_regulation of P2RX7 Positive_regulation of Localization of Il1b 1 0.02 0.71 0.34
25 INT217041 TNF Positive_regulation of Gene_expression of P2RX7 1 0.50 0.81 0.34
26 INT205713 Positive_regulation of P2rx7 Positive_regulation of Gene_expression of IL8 1 0.03 0.77 0.33
27 INT217025 P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
28 INT217024 Regulation of P2rx7 Regulation of Gene_expression of Ik 1 0.00 0.25 0.33
29 INT205703 P2rx7 Regulation of Positive_regulation of Casp1 1 0.11 0.66 0.33
30 INT205711 P2rx7 Regulation of Localization of IL8 1 0.02 0.92 0.33
31 INT315385 Adcyap1 Positive_regulation of Phosphorylation of Bad 1 0.05 0.44 0.32
32 INT145682 Binding of P2rx4 and P2rx7 2 0.25 0.36 0.31
33 INT242399 Cyp19a1 Negative_regulation of Gene_expression of Bad 1 0.00 1.32 0.31
34 INT29984 Bad Positive_regulation of Localization of Prl 1 0.15 0 0.3
35 INT215789 Fig4 Positive_regulation of Localization of P2rx7 1 0.03 0.53 0.29
36 INT172905 Binding of Bad and Bcl2 3 0.08 6.46 0.27
37 INT172901 Binding of Bad and Bcl2l1 3 0.13 6.51 0.27
38 INT205701 P2rx7 Positive_regulation of Il1 1 0.04 0.8 0.25
39 INT185489 Atp5o Negative_regulation of P2rx7 1 0.01 0.29 0.24
40 INT216911 Positive_regulation of P2rx7 Positive_regulation of Localization of Plg 1 0.02 0.13 0.23
41 INT120376 Bad Positive_regulation of Gene_expression of Oxtr 1 0.08 0 0.22
42 INT107219 Binding of P2rx7 and Atp5o 1 0.03 0.07 0.21
43 INT216946 P2rx7 Regulation of Il10 1 0.28 0.17 0.21
44 INT107223 APEH Negative_regulation of P2rx7 1 0.00 0.13 0.21
45 INT322011 BSG Regulation of P2RX7 1 0.00 0.48 0.21
46 INT315386 Adcyap1 Positive_regulation of Bad 1 0.03 0.52 0.2
47 INT205710 CAMP Positive_regulation of P2rx7 1 0.02 0.47 0.19
48 INT263321 Akt1 Regulation of Bad 1 0.00 0.74 0.13
49 INT270827 P2rx7 Positive_regulation of Localization of Panx1 1 0.41 0.18 0.13
50 INT182273 EDN1 Regulation of Gene_expression of BAD 1 0.11 0.73 0.12
51 INT216945 Positive_regulation of P2rx7 Positive_regulation of Positive_regulation of Casp1 1 0.14 0.18 0.12
52 INT322037 Binding of P2RX7 and Myh1 1 0.06 0 0.12
53 INT74504 Binding of P2rx7 and Rp2 1 0.02 0.19 0.11
54 INT265888 BCL2 Regulation of Gene_expression of BAD 1 0.04 1.08 0.1
55 INT265889 BAX Regulation of Gene_expression of BAD 1 0.06 1.08 0.1
56 INT205708 Binding of Icam1 and P2rx7 1 0.08 1.03 0.09
57 INT275184 Bad Positive_regulation of Positive_regulation of Bcl2l1 1 0.12 0.62 0.09
58 INT275183 Bad Positive_regulation of Gene_expression of Bcl2 1 0.08 0.63 0.09
59 INT217036 IRF6 Positive_regulation of Gene_expression of P2rx7 1 0.02 0 0.09
60 INT270824 Binding of P2rx7 and Panx1 1 0.34 0.15 0.09
61 INT304464 Binding of P2rx7 and P2rx6 1 0.05 0 0.09
62 INT243156 Positive_regulation of P2rx7 Positive_regulation of NOS1 1 0.00 0.08 0.08
63 INT270829 P2rx7 Positive_regulation of Panx1 1 0.66 0.08 0.08
64 INT340420 Hmmr Regulation of P2rx7 1 0.01 1.12 0.08
65 INT270835 Positive_regulation of P2rx7 Positive_regulation of Localization of DPEP1 1 0.04 0.08 0.07
66 INT265893 BAD Regulation of FOXO1 1 0.03 1.08 0.06
67 INT340427 Positive_regulation of P2rx7 Positive_regulation of Regulation of Pkhd1 1 0.01 1 0.05
68 INT331153 Akt1 Positive_regulation of Bad 1 0.03 0.92 0.04
69 INT331155 Akt1 Positive_regulation of Binding of Bad 1 0.04 0.93 0.04
70 INT270825 P2rx7 Positive_regulation of Slc37a4 1 0.01 0 0.04
71 INT331156 Akt1 Positive_regulation of Phosphorylation of Bad 1 0.02 0.91 0.04
72 INT266661 AKT1 Regulation of BAD 2 0.10 1.86 0.03
73 INT303056 Rorb Regulation of Bad 1 0.00 0.52 0.03
74 INT185856 Binding of BAD and BCL2L1 4 0.39 2.73 0
75 INT292454 Binding of BAD and BCL2 2 0.03 1.73 0
76 INT229815 Fos Regulation of Bad 1 0.09 0.31 0
77 INT292444 BAD Positive_regulation of Phosphorylation of PTK2 1 0.13 0.9 0
78 INT292447 Negative_regulation of Binding of BAD and BCL2L1 1 0.02 0.81 0
79 INT185854 BID Positive_regulation of BAD 1 0.39 0.74 0
80 INT285909 AKT1 Regulation of Phosphorylation of Bad 1 0.01 0.4 0
81 INT302145 Positive_regulation of AKT1 Positive_regulation of Phosphorylation of BAD 1 0.07 0.9 0
82 INT302137 Binding of BAD and BAK1 1 0.07 0.93 0
83 INT292462 LAMB2 Positive_regulation of BAD 1 0.00 0.7 0
84 INT217031 Binding of P2rx7 and Positive_regulation of Casp1 1 0.02 0 0
85 INT335953 Binding of BCL2 and Bad 1 0.14 0.37 0
86 INT327970 GOPC Regulation of Gene_expression of BAD 1 0.08 0.6 0
87 INT292458 Negative_regulation of Binding of BAD and BCL2 1 0.01 0.81 0
88 INT292459 Phosphorylation of BAD Negative_regulation of Binding of BCL2L1 1 0.02 0.82 0
89 INT295048 Bad Regulation of RYBP 1 0.00 1.64 0
90 INT292502 Mlph Regulation of Gene_expression of BAD 1 0.01 0.4 0
91 INT217032 Binding of P2rx7 and Positive_regulation of Il1 1 0.02 0 0
92 INT172908 Binding of Bad and Bax 1 0.01 1.34 0
93 INT329745 AKT1 Negative_regulation of BAD 1 0.03 1.43 0
94 INT292508 Mlph Regulation of Phosphorylation of BAD 1 0.01 1.52 0
95 INT201760 Binding of BCL2L1 and Positive_regulation of Bad 1 0.01 0.3 0
96 INT216942 Positive_regulation of P2rx7 Positive_regulation of Casp1 1 0.14 0 0
97 INT307460 P2rx7 Positive_regulation of Phosphorylation of Gsk3a 1 0.02 0 0
98 INT292501 Mlph Positive_regulation of Phosphorylation of BAD 1 0.01 0.39 0
99 INT335951 Binding of Bad and Tgif2lx1 1 0.00 0.37 0
100 INT302172 Binding of BAD and BAX 1 0.06 0.93 0
101 INT292457 PTK2 Regulation of BAD 1 0.03 0.76 0
102 INT201743 Bad Positive_regulation of Positive_regulation of Bax 1 0.00 0.43 0
103 INT302132 Negative_regulation of Binding of BAD and BAK1 1 0.06 0.93 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for pore complex assembly. They are ordered first by their pain relevance and then by number of times they were reported in pore complex assembly. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT49519 Gene_expression of P2rx7 84 0.76 36.88 34.69
2 INT88327 Gene_expression of P2rx7 109 0.77 48.86 22.41
3 INT23787 Positive_regulation of P2rx7 36 0.68 23.54 19.45
4 INT127046 Gene_expression of P2RX7 65 0.78 34.28 14.76
5 INT121241 Positive_regulation of P2rx7 65 0.69 40.94 13.59
6 INT137980 Positive_regulation of P2RX7 30 0.67 22.49 10
7 INT73427 Localization of P2rx7 24 0.79 8.65 9.87
8 INT48257 Negative_regulation of P2rx7 18 0.41 7.82 8.42
9 INT13385 Gene_expression of Bad 60 0.76 41.86 6.52
10 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25
11 INT94608 Regulation of P2rx7 19 0.23 8.06 6.19
12 INT68882 Binding of P2rx7 16 0.23 4.33 6.17
13 INT145680 Regulation of P2rx7 22 0.61 11.92 5.42
14 INT185484 Positive_regulation of Gene_expression of P2rx7 8 0.31 7.44 4.28
15 INT33229 Gene_expression of Bad 9 0.70 6.95 4.15
16 INT51654 Regulation of Bad 21 0.40 12.18 4.06
17 INT127047 Negative_regulation of P2RX7 10 0.39 7.17 4.01
18 INT144830 Positive_regulation of Gene_expression of P2rx7 22 0.68 9.78 3.92
19 INT129441 Regulation of Gene_expression of P2rx7 8 0.24 4.29 3.32
20 INT144828 Binding of P2rx7 19 0.47 7.84 3.16
21 INT3437 Negative_regulation of Bad 5 0.48 1.66 2.99
22 INT191120 Regulation of P2RX7 8 0.41 5.29 2.96
23 INT137978 Localization of P2RX7 6 0.73 5.04 2.84
24 INT107216 Negative_regulation of Gene_expression of P2rx7 10 0.56 3.39 2.61
25 INT29983 Localization of Bad 5 0.28 4.44 2.52
26 INT108333 Phosphorylation of BAD 43 0.68 33.77 2.45
27 INT137972 Binding of P2RX7 12 0.36 8.01 2.18
28 INT144829 Localization of P2rx7 12 0.79 2.92 2.12
29 INT172874 Phosphorylation of Bad 31 0.80 27.46 2.07
30 INT216936 Negative_regulation of Gene_expression of P2rx7 5 0.42 2.59 1.84
31 INT43143 Binding of Bad 8 0.21 5.12 1.81
32 INT141385 Positive_regulation of Gene_expression of P2RX7 7 0.62 3.95 1.73
33 INT93427 Negative_regulation of Bad 4 0.02 2.5 1.63
34 INT23786 Positive_regulation of Positive_regulation of P2rx7 5 0.44 2.21 1.58
35 INT125735 Transcription of P2rx7 3 0.62 1.34 1.58
36 INT5855 Positive_regulation of Bad 12 0.61 12.26 1.56
37 INT119835 Positive_regulation of Gene_expression of BAD 6 0.44 7.66 1.51
38 INT18495 Regulation of Bad 6 0.19 4.79 1.45
39 INT215757 Transcription of P2rx7 3 0.21 1.84 1.45
40 INT205691 Regulation of Gene_expression of P2rx7 5 0.44 3.25 1.42
41 INT119830 Gene_expression of BAD 24 0.50 20.05 1.41
42 INT154081 Negative_regulation of Localization of Bad 2 0.16 2.06 1.31
43 INT205690 Positive_regulation of Positive_regulation of P2rx7 14 0.68 6.26 1.3
44 INT108340 Negative_regulation of Phosphorylation of BAD 11 0.49 8.29 1.02
45 INT216661 Regulation of Positive_regulation of P2rx7 1 0.07 0 1
46 INT191121 Regulation of Gene_expression of P2RX7 3 0.36 3.69 0.99
47 INT113887 Positive_regulation of Negative_regulation of P2rx7 1 0.22 1.02 0.96
48 INT215567 Positive_regulation of Positive_regulation of P2RX7 2 0.45 0.07 0.93
49 INT159668 Positive_regulation of Bad 8 0.45 6.32 0.89
50 INT151776 Positive_regulation of Transcription of P2rx7 1 0.03 0.53 0.86
51 INT108341 Positive_regulation of BAD 8 0.42 8.75 0.85
52 INT133767 Transcription of Bad 2 0.57 1.72 0.84
53 INT271589 Regulation of Transcription of P2rx7 1 0.05 0.5 0.78
54 INT275180 Positive_regulation of Phosphorylation of Bad 4 0.40 3.79 0.77
55 INT278119 Positive_regulation of Localization of P2RX7 2 0.45 1.14 0.77
56 INT201628 Positive_regulation of Gene_expression of Bad 12 0.68 13.86 0.72
57 INT125734 Negative_regulation of Transcription of P2rx7 1 0.38 0.81 0.67
58 INT153802 Positive_regulation of Localization of BAD 1 0.30 0.64 0.66
59 INT153799 Localization of BAD 1 0.45 0.63 0.66
60 INT331152 Positive_regulation of Localization of Bad 1 0.19 1.35 0.64
61 INT331150 Negative_regulation of Gene_expression of Bad 1 0.10 1.33 0.63
62 INT185485 Negative_regulation of Localization of P2rx7 1 0.26 0.95 0.62
63 INT108339 Positive_regulation of Phosphorylation of BAD 6 0.58 3.95 0.55
64 INT150000 Positive_regulation of Positive_regulation of BAD 2 0.14 3.1 0.55
65 INT153099 Negative_regulation of Positive_regulation of P2rx7 1 0.42 0.25 0.5
66 INT142871 Negative_regulation of Gene_expression of Bad 7 0.51 6.52 0.49
67 INT215732 Negative_regulation of Binding of P2rx7 1 0.11 0.74 0.49
68 INT159667 Negative_regulation of Positive_regulation of Bad 4 0.20 3.13 0.48
69 INT105886 Phosphorylation of Bad 3 0.23 2.15 0.47
70 INT149999 Negative_regulation of Gene_expression of BAD 4 0.13 5.46 0.45
71 INT278114 Negative_regulation of Negative_regulation of P2rx7 1 0.21 0 0.45
72 INT215741 Positive_regulation of Transcription of P2rx7 1 0.15 1.15 0.43
73 INT217017 Transcription of P2RX7 1 0.27 0.36 0.39
74 INT294539 Binding of BAD 3 0.36 2.35 0.37
75 INT192983 Regulation of Regulation of Bad 1 0.01 0.3 0.33
76 INT121239 Regulation of Positive_regulation of P2rx7 2 0.61 1.32 0.32
77 INT216937 Regulation of Binding of P2rx7 1 0.44 0.08 0.29
78 INT302274 Negative_regulation of Positive_regulation of BAD 1 0.13 1.31 0.27
79 INT135807 Positive_regulation of Negative_regulation of Bad 1 0.35 0.24 0.27
80 INT146278 Negative_regulation of Gene_expression of P2RX7 2 0.42 0.21 0.25
81 INT322030 Regulation of Positive_regulation of P2RX7 1 0.41 0.55 0.24
82 INT216938 Negative_regulation of Localization of P2rx7 1 0.37 0.25 0.24
83 INT216940 Negative_regulation of Binding of P2rx7 1 0.37 0.15 0.2
84 INT206970 Negative_regulation of BAD 3 0.22 3.3 0.19
85 INT216889 Phosphorylation of P2rx7 1 0.23 0 0.18
86 INT201637 Regulation of Gene_expression of Bad 4 0.23 2.99 0.17
87 INT273054 Positive_regulation of Binding of Bad 2 0.14 2.66 0.16
88 INT307467 Regulation of Binding of P2rx7 1 0.08 0 0.16
89 INT270813 Positive_regulation of Localization of P2rx7 1 0.46 0.24 0.15
90 INT161613 Regulation of Phosphorylation of BAD 3 0.11 2.36 0.13
91 INT153486 Positive_regulation of Gene_expression of Bad 1 0.62 0.74 0.13
92 INT172857 Binding of Bad 2 0.36 2.86 0.12
93 INT322025 Positive_regulation of Binding of P2RX7 1 0.45 0 0.1
94 INT162014 Protein_catabolism of Bad 1 0.76 0.29 0.1
95 INT275179 Localization of Bad 2 0.69 0.66 0.09
96 INT307481 Phosphorylation of P2rx7 1 0.15 0.35 0.08
97 INT307480 Positive_regulation of Phosphorylation of P2rx7 1 0.09 0.35 0.08
98 INT206969 Regulation of BAD 8 0.15 5.32 0.05
99 INT351575 Negative_regulation of Positive_regulation of P2RX7 1 0.41 1.81 0.04
100 INT224008 Regulation of Localization of P2RX7 1 0.22 0.74 0.03
101 INT292467 Regulation of Gene_expression of BAD 2 0.11 1.38 0
102 INT175515 Regulation of Phosphorylation of Bad 1 0.08 1.69 0
103 INT330030 Positive_regulation of Regulation of Bad 1 0.21 0.71 0
104 INT335937 Negative_regulation of Phosphorylation of Bad 1 0.15 0.41 0
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