GO:0046970

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Name NAD-dependent histone deacetylase activity (H4-K16 specific)
Categary Function
Go Slim No
Go Link GO:0046970
Unique Molecular Interactions 81
Total Molecular Interactions 97
Total Single Events 695
Pain Genes Associated 11

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for NAD-dependent histone deacetylase activity (H4-K16 specific). They are ordered first by their pain relevance and then by number of times they were reported for NAD-dependent histone deacetylase activity (H4-K16 specific). Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78
2 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78
3 INT304578 Negative_regulation of HDAC9 Positive_regulation of Gene_expression of Bdnf 1 0.06 0.9 0.49
4 INT333893 Negative_regulation of HDAC9 Negative_regulation of Gene_expression of TNF 1 0.09 1.03 0.34
5 INT333918 HDAC1 Regulation of Trp53 1 0.03 1.24 0.3
6 INT346957 HDAC9 Positive_regulation of Gene_expression of GSR 1 0.03 1.28 0.27
7 INT277613 Binding of HDAC9 and Runx2 1 0.02 0.59 0.26
8 INT317773 Positive_regulation of GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
9 INT317775 GATA3 Positive_regulation of HDAC1 1 0.23 0.69 0.25
10 INT317771 GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
11 INT317776 Positive_regulation of GSR Positive_regulation of HDAC1 1 0.10 0.69 0.25
12 INT333892 TNF Positive_regulation of Gene_expression of HDAC1 1 0.09 0.46 0.23
13 INT97691 Binding of REST and HDAC9 1 0.26 0.09 0.23
14 INT28722 Binding of T2 and Hdac11 1 0.11 0.14 0.18
15 INT191355 HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
16 INT191354 Negative_regulation of HDAC4 Positive_regulation of Gene_expression of Shc1 1 0.02 1.07 0.16
17 INT347638 Negative_regulation of Binding of Atp9a and Hdac4 1 0.01 0.97 0.14
18 INT347639 Binding of Atp9a and Hdac4 1 0.01 0.97 0.14
19 INT138195 Binding of HDAC4 and Creb1 1 0.03 0.17 0.13
20 INT200326 Hdac1 Negative_regulation of Lhcgr 1 0.03 0 0.12
21 INT200304 Hdac2 Negative_regulation of Rorb 1 0.00 0 0.12
22 INT200318 Hdac1 Negative_regulation of Transcription of Lhcgr 1 0.03 0 0.12
23 INT200346 Hdac2 Negative_regulation of Lhcgr 1 0.04 0 0.12
24 INT200306 Hdac1 Negative_regulation of Rorb 1 0.00 0 0.12
25 INT200332 Binding of Rcor2 and Hdac1 1 0.15 0.3 0.12
26 INT200347 Hdac2 Negative_regulation of Transcription of Lhcgr 1 0.04 0 0.12
27 INT28723 Negative_regulation of Binding of T2 and Hdac11 1 0.10 0.08 0.1
28 INT351011 Binding of HDAC9 and TSPYL2 1 0.04 0.63 0.08
29 INT268679 Binding of HDAC1 and NCOR2 3 0.17 2.8 0.07
30 INT331790 Binding of gr and Hdac2 1 0.01 0.74 0.07
31 INT331791 Akt1 Negative_regulation of Hdac2 1 0.03 0.8 0.07
32 INT331798 Regulation of Binding of gr and Hdac2 1 0.02 0.75 0.07
33 INT277615 Positive_regulation of Binding of ZNF238 and Hdac3 1 0.38 0.06 0.07
34 INT277614 Binding of ZNF238 and Hdac3 1 0.29 0.06 0.07
35 INT268678 Binding of HDAC2 and NCOR2 1 0.18 2.67 0.07
36 INT298806 Binding of Hdac3 and Rb1 1 0.02 0.77 0.05
37 INT339979 Binding of PRDX2 and HDAC9 1 0.02 0.16 0.05
38 INT268676 Binding of HDAC1 and BCOR 1 0.01 1.31 0.04
39 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03
40 INT348592 Binding of HDAC1 and PPARG 1 0.23 0 0.03
41 INT319171 Binding of Cgn and Hdac1 1 0.00 0 0
42 INT196948 Hmga2 Positive_regulation of Hdac1 1 0.36 0.23 0
43 INT332881 Negative_regulation of Binding of Hdac3 and Ncor1 1 0.28 0.18 0
44 INT200647 HDAC4 Positive_regulation of CASP9 1 0.10 0.93 0
45 INT333685 Binding of Trp53 and Hdac1 1 0.26 0.55 0
46 INT284920 Binding of HDAC1 and NCOR1 1 0.03 0.13 0
47 INT287875 EP300 Negative_regulation of HDAC9 1 0.04 0.51 0
48 INT284917 RUNX1T1 Regulation of HDAC9 1 0.19 1.09 0
49 INT284914 Binding of HDAC1 and NCK1 1 0.00 0.13 0
50 INT311398 Positive_regulation of Celf1 Positive_regulation of Hdac1 1 0.12 0.19 0
51 INT339977 Positive_regulation of Binding of HDAC3 and HDAC7 1 0.23 0.52 0
52 INT196946 Binding of E2f1 and Hdac1 1 0.26 0.65 0
53 INT235166 Binding of Hdac3 and Atxn1 1 0.02 0.28 0
54 INT337401 Binding of E2F1 and HDAC1 1 0.07 0 0
55 INT297615 Binding of TSC1 and HDAC9 1 0.01 0.4 0
56 INT332894 Binding of Ahrr and Hdac3 1 0.01 0.08 0
57 INT265383 Hsp90aa1 Negative_regulation of HDAC9 1 0.06 0.7 0
58 INT332896 Binding of Hdac3 and Ncor1 1 0.31 1.38 0
59 INT339978 Binding of HDAC3 and HDAC7 1 0.17 1.04 0
60 INT277610 Binding of Runx2 and Hdac4 1 0.32 0.78 0
61 INT332878 Hdac3 Negative_regulation of Gene_expression of Arntl 1 0.42 0.17 0
62 INT355201 Binding of HDAC9 and Gopc 1 0.01 0.06 0
63 INT200650 HDAC4 Regulation of Gene_expression of AKT1 1 0.16 0.66 0
64 INT326197 Negative_regulation of HDAC9 Negative_regulation of EPHB2 1 0.17 0.15 0
65 INT196956 Binding of Hmga2 and Hdac1 1 0.25 0.23 0
66 INT235167 Binding of Hdac3 and Ncor2 1 0.01 0.28 0
67 INT196941 Hdac1 Negative_regulation of Rb1 1 0.27 0.44 0
68 INT339980 Binding of MEF2D and HDAC7 1 0.19 0.78 0
69 INT196944 Binding of Rb1 and Hdac1 1 0.24 0.4 0
70 INT301470 Binding of Smyd2 and Hdac1 1 0.35 0.31 0
71 INT319170 Casp3 Regulation of Hdac1 1 0.01 0.27 0
72 INT332892 Ncor1 Positive_regulation of Hdac3 1 0.45 0.18 0
73 INT200644 HDAC4 Positive_regulation of CASP8 1 0.07 0.92 0
74 INT332879 Negative_regulation of Ncor1 Positive_regulation of Hdac3 1 0.28 0.18 0
75 INT284995 Binding of HDAC1 and Sin3a 1 0.00 0.13 0
76 INT177783 Binding of HDAC1 and PCNA 1 0.09 0.5 0
77 INT200724 HDAC9 Positive_regulation of TP53 1 0.36 0.27 0
78 INT333684 Binding of Hr and Hdac1 1 0.19 0.56 0
79 INT277611 Binding of Mef2c and Hdac4 1 0.34 1.12 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for NAD-dependent histone deacetylase activity (H4-K16 specific). They are ordered first by their pain relevance and then by number of times they were reported in NAD-dependent histone deacetylase activity (H4-K16 specific). Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9
2 INT177831 Gene_expression of HDAC1 24 0.65 21.37 8.37
3 INT192225 Gene_expression of HDAC9 35 0.58 32.82 6.36
4 INT333909 Positive_regulation of Gene_expression of HDAC1 1 0.44 14.15 5.9
5 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42
6 INT97692 Positive_regulation of HDAC9 17 0.45 14.88 5.11
7 INT133648 Regulation of HDAC9 14 0.60 10.01 2.18
8 INT191154 Binding of HDAC9 20 0.36 14.12 1.83
9 INT277591 Gene_expression of Hdac4 22 0.77 7.77 1.79
10 INT272884 Gene_expression of Hdac2 19 0.43 14.55 1.48
11 INT332792 Positive_regulation of Gene_expression of HDAC9 5 0.45 4.61 1.44
12 INT333914 Transcription of HDAC1 1 0.34 3.04 1.37
13 INT277581 Positive_regulation of Hdac4 4 0.50 1.47 1.25
14 INT258053 Positive_regulation of Negative_regulation of HDAC9 8 0.27 7.37 1.23
15 INT272879 Negative_regulation of Hdac2 8 0.37 5.96 1.17
16 INT260447 Binding of HDAC1 8 0.23 4.47 1.12
17 INT68339 Gene_expression of HDAC2 3 0.51 1.71 1.1
18 INT333907 Positive_regulation of HDAC1 4 0.32 3.07 1.03
19 INT234473 Gene_expression of HDAC4 8 0.18 6.28 0.99
20 INT317791 Localization of HDAC2 2 0.50 2.31 0.99
21 INT200250 Binding of Hdac2 6 0.22 2.97 0.76
22 INT70423 Binding of HDAC3 1 0.01 0.36 0.75
23 INT284955 Localization of HDAC1 2 0.47 1.71 0.74
24 INT272883 Positive_regulation of Gene_expression of Hdac2 5 0.30 4.64 0.7
25 INT272886 Negative_regulation of Gene_expression of Hdac2 4 0.23 4.63 0.69
26 INT272868 Positive_regulation of Hdac2 3 0.27 2.15 0.5
27 INT177842 Negative_regulation of HDAC1 6 0.31 4.65 0.49
28 INT333910 Positive_regulation of Gene_expression of HDAC4 2 0.07 1.5 0.49
29 INT179685 Positive_regulation of HDAC4 3 0.24 4.09 0.48
30 INT333915 Negative_regulation of Binding of HDAC9 1 0.21 0.83 0.41
31 INT277579 Binding of Hdac4 1 0.37 3.84 0.38
32 INT196927 Binding of Hdac1 9 0.36 2.31 0.36
33 INT277604 Negative_regulation of Hdac4 4 0.51 2.89 0.36
34 INT333916 Negative_regulation of HDAC2 2 0.18 1.38 0.36
35 INT277598 Regulation of Gene_expression of Hdac4 1 0.45 0.91 0.36
36 INT272882 Positive_regulation of Binding of Hdac2 2 0.20 1.12 0.32
37 INT333912 Regulation of Positive_regulation of HDAC9 1 0.19 0.63 0.31
38 INT177856 Negative_regulation of Gene_expression of HDAC2 1 0.19 0.12 0.3
39 INT196917 Gene_expression of Hdac1 15 0.71 3.66 0.28
40 INT339992 Positive_regulation of Transcription of HDAC7 1 0.45 1.56 0.28
41 INT124568 Regulation of HDAC4 5 0.24 3.03 0.27
42 INT340001 Transcription of HDAC7 1 0.61 1.5 0.27
43 INT234466 Regulation of Negative_regulation of HDAC9 2 0.25 1.82 0.26
44 INT234461 Negative_regulation of Gene_expression of HDAC9 5 0.24 2.74 0.24
45 INT277584 Negative_regulation of Gene_expression of Hdac4 1 0.43 0.85 0.21
46 INT277594 Positive_regulation of Localization of Hdac4 1 0.50 1.71 0.21
47 INT277593 Localization of Hdac4 1 0.75 2.07 0.2
48 INT277600 Positive_regulation of Gene_expression of Hdac4 1 0.60 0.48 0.2
49 INT277393 Gene_expression of HDAC7 2 0.65 4.71 0.18
50 INT191155 Binding of HDAC4 5 0.08 2.79 0.17
51 INT298778 Phosphorylation of Hdac3 1 0.44 0.67 0.17
52 INT133646 Positive_regulation of Regulation of HDAC9 1 0.49 0.83 0.17
53 INT339984 Positive_regulation of HDAC7 1 0.45 1.07 0.16
54 INT277601 Positive_regulation of Positive_regulation of Hdac4 1 0.50 0.18 0.16
55 INT266991 Regulation of Hdac2 2 0.07 0.74 0.15
56 INT277582 Regulation of Hdac4 1 0.45 0.36 0.14
57 INT265376 Gene_expression of Hdac3 4 0.51 1.8 0.13
58 INT337484 Gene_expression of HDAC3 2 0.37 0.15 0.13
59 INT341562 Negative_regulation of Gene_expression of HDAC3 1 0.23 0.05 0.13
60 INT196934 Negative_regulation of Hdac1 4 0.39 1.41 0.11
61 INT234460 Negative_regulation of Gene_expression of HDAC4 2 0.04 1.55 0.11
62 INT331783 Regulation of Negative_regulation of Hdac1 1 0.04 0.98 0.11
63 INT234465 Regulation of Negative_regulation of HDAC4 1 0.04 0.74 0.11
64 INT331785 Negative_regulation of Gene_expression of Hdac3 1 0.04 0.86 0.1
65 INT28720 Binding of Hdac11 1 0.26 0.07 0.09
66 INT331786 Negative_regulation of Binding of Hdac2 1 0.11 1.2 0.08
67 INT284980 Positive_regulation of Protein_catabolism of HDAC2 1 0.20 0.81 0.08
68 INT284976 Protein_catabolism of HDAC2 1 0.28 0.8 0.08
69 INT346968 Positive_regulation of Transcription of HDAC9 1 0.22 0.21 0.07
70 INT346969 Transcription of HDAC9 1 0.23 0.21 0.07
71 INT331784 Negative_regulation of Positive_regulation of Hdac2 1 0.11 0.52 0.05
72 INT191153 Negative_regulation of Negative_regulation of HDAC9 1 0.09 0.57 0.05
73 INT277599 Phosphorylation of Hdac4 1 0.82 3.24 0.05
74 INT265372 Localization of Hdac3 3 0.55 0.6 0.04
75 INT284973 Negative_regulation of Negative_regulation of HDAC1 1 0.20 1.59 0.04
76 INT265373 Regulation of Hdac3 2 0.17 1.1 0.03
77 INT326227 Phosphorylation of HDAC9 1 0.22 2.32 0.03
78 INT259662 Positive_regulation of Regulation of HDAC4 1 0.03 0.77 0.03
79 INT328554 Regulation of HDAC1 1 0.26 1.12 0.03
80 INT331778 Regulation of Phosphorylation of Hdac2 1 0.11 0.49 0.03
81 INT331787 Phosphorylation of Hdac2 1 0.20 0.49 0.03
82 INT332926 Localization of HDAC4 1 0.10 0.11 0.03
83 INT277595 Localization of Hdac1 4 0.73 0.81 0
84 INT277612 Localization of HDAC9 3 0.45 0.55 0
85 INT277405 Negative_regulation of Gene_expression of HDAC7 2 0.41 1.52 0
86 INT265379 Positive_regulation of Binding of HDAC9 2 0.19 1.06 0
87 INT265371 Binding of Hdac3 2 0.27 0.94 0
88 INT261751 Regulation of Hdac1 2 0.41 0 0
89 INT200682 Phosphorylation of HDAC4 2 0.44 1.24 0
90 INT350509 Phosphorylation of HDAC1 1 0.25 0.62 0
91 INT265375 Negative_regulation of Hdac3 1 0.36 0.78 0
92 INT337478 Binding of HDAC2 1 0.14 0.07 0
93 INT319154 Transcription of Hdac1 1 0.66 0 0
94 INT319156 Negative_regulation of Gene_expression of Hdac1 1 0.39 0.22 0
95 INT277580 Regulation of Localization of Hdac4 1 0.39 0 0
96 INT339999 Positive_regulation of Gene_expression of HDAC7 1 0.45 1.97 0
97 INT277596 Phosphorylation of Hdac1 1 0.61 0.59 0
98 INT326229 Regulation of Phosphorylation of HDAC9 1 0.07 0.48 0
99 INT200668 Regulation of Phosphorylation of HDAC4 1 0.24 0.71 0
100 INT326233 Negative_regulation of Phosphorylation of HDAC9 1 0.11 0 0
101 INT319169 Negative_regulation of Transcription of Hdac1 1 0.54 0 0
102 INT277577 Transcription of Hdac4 1 0.69 0 0
103 INT355198 Positive_regulation of Localization of Hdac1 1 0.19 0.48 0
104 INT350933 Gene_expression of Hdac11 1 0.33 0.12 0
105 INT340003 Localization of HDAC7 1 0.67 1.61 0
106 INT239368 Negative_regulation of Binding of HDAC4 1 0.06 1.44 0
107 INT355200 Regulation of Gene_expression of HDAC9 1 0.14 1.77 0
108 INT338233 Regulation of Gene_expression of HDAC4 1 0.03 0.18 0
109 INT319162 Regulation of Gene_expression of Hdac1 1 0.56 0 0
110 INT319152 Positive_regulation of Gene_expression of Hdac1 1 0.46 0 0
111 INT277603 Negative_regulation of Phosphorylation of Hdac4 1 0.43 0.39 0
112 INT337460 Positive_regulation of Gene_expression of HDAC3 1 0.17 0.1 0
113 INT311329 Positive_regulation of Hdac1 1 0.19 0.14 0
114 INT277377 Phosphorylation of HDAC7 1 0.79 0.36 0
115 INT277399 Binding of HDAC7 1 0.36 1.67 0
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