GO:0047498

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Name calcium-dependent phospholipase A2 activity
Categary Function
Go Slim No
Go Link GO:0047498
Unique Molecular Interactions 88
Total Molecular Interactions 98
Total Single Events 1400
Pain Genes Associated 10

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for calcium-dependent phospholipase A2 activity. They are ordered first by their pain relevance and then by number of times they were reported for calcium-dependent phospholipase A2 activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT91350 Binding of Pla2g4a and RYBP 1 0.00 1.15 2.65
2 INT68160 Alox5 Positive_regulation of Positive_regulation of Pla2g1b 1 0.03 0.64 1.13
3 INT68156 Pla2g1b Positive_regulation of Positive_regulation of Alox5 1 0.03 0.64 1.13
4 INT68158 Pla2g1b Positive_regulation of Pdpk1 1 0.05 0.63 1.12
5 INT68159 Pla2g1b Positive_regulation of Positive_regulation of Pdpk1 1 0.05 0.64 1.12
6 INT68161 Mthfs Positive_regulation of Positive_regulation of Pla2g1b 1 0.03 0.64 1.12
7 INT68155 Pla2g1b Positive_regulation of Positive_regulation of Mthfs 1 0.03 0.64 1.12
8 INT296179 Pla2g2a Positive_regulation of Apcs 1 0.17 7.13 0.96
9 INT317559 Binding of Hint1 and Pla2g4a 1 0.01 0.06 0.94
10 INT185417 Binding of ALOX5 and PLA2G2A 4 0.16 3.13 0.9
11 INT270218 P2rx3 Positive_regulation of Pla2g4a 1 0.34 0.63 0.85
12 INT231390 Pla2g4a Regulation of Pla2g2a 1 0.08 0.92 0.77
13 INT231388 Pla2g4a Regulation of Pla2g6 1 0.08 0.92 0.77
14 INT308484 Car2 Positive_regulation of Pla2g4a 1 0.03 1.23 0.65
15 INT189020 Tacr1 Positive_regulation of Pla2g1b 1 0.14 0.13 0.65
16 INT219277 Mapkapk2 Positive_regulation of Pla2g1b 1 0.03 0.46 0.61
17 INT219278 Mapkapk2 Positive_regulation of Pla2g2a 1 0.05 0.46 0.61
18 INT219280 Mapk14 Positive_regulation of Pla2g2a 1 0.33 0.46 0.61
19 INT219282 Mapk14 Positive_regulation of Pla2g1b 1 0.18 0.46 0.61
20 INT86828 Pla2g2a Regulation of Gene_expression of Pla2g1b 1 0.00 0.24 0.59
21 INT270099 Negative_regulation of Binding of CPOX and PLA2G2A 1 0.01 0.51 0.59
22 INT270100 Negative_regulation of Binding of ALOX5 and PLA2G2A 1 0.01 0.51 0.59
23 INT86829 Pla2g1b Regulation of Gene_expression of Pla2g2a 1 0.00 0.24 0.59
24 INT270103 Binding of CPOX and PLA2G2A 1 0.01 0.5 0.58
25 INT172144 IL4 Negative_regulation of Transcription of PLA2G4A 1 0.02 0.82 0.58
26 INT270102 ALOX5 Negative_regulation of PLA2G2A 1 0.01 0.49 0.57
27 INT270101 CPOX Negative_regulation of PLA2G2A 1 0.01 0.48 0.56
28 INT50497 Edn1 Positive_regulation of Pla2g1b 1 0.01 0.23 0.45
29 INT25992 Pla2g5 Positive_regulation of Vip 1 0.49 0 0.45
30 INT248146 PLA2G6 Negative_regulation of Phosphorylation of PLA2G4A 1 0.07 0.72 0.4
31 INT157171 Binding of PTGS2 and Pla2g1b 1 0.02 0.26 0.37
32 INT270220 Negative_regulation of Ephb1 Negative_regulation of Positive_regulation of Pla2g4a 1 0.13 1 0.36
33 INT102324 Nme3 Negative_regulation of Pla2g1b 1 0.05 1.07 0.35
34 INT37559 F9 Regulation of Pla2g1b 1 0.04 0.95 0.31
35 INT243273 Hrh1 Positive_regulation of Pla2g1b 1 0.10 0.3 0.29
36 INT243280 Hrh1 Positive_regulation of Pla2g5 1 0.22 0.3 0.29
37 INT243278 Positive_regulation of Hrh1 Positive_regulation of Pla2g1b 1 0.10 0.3 0.29
38 INT142371 Trpv1 Positive_regulation of Positive_regulation of Pla2g1b 1 0.35 0.3 0.29
39 INT243274 Positive_regulation of Hrh1 Positive_regulation of Pla2g5 1 0.22 0.3 0.29
40 INT64789 ITIH4 Positive_regulation of Positive_regulation of Pla2g1b 1 0.19 0.55 0.24
41 INT55902 Negative_regulation of Pla2g1b Negative_regulation of Localization of Ptafr 1 0.11 0.35 0.24
42 INT80138 PLA2G2A Positive_regulation of Localization of TBXA2R 1 0.30 0.15 0.24
43 INT207147 Pla2g1b Positive_regulation of Localization of F2rl1 1 0.03 0.73 0.18
44 INT68742 Pla2g1b Negative_regulation of Cxcl2 1 0.04 1.17 0.18
45 INT40845 Ca2 Positive_regulation of Pla2g1b 1 0.16 0 0.16
46 INT43118 Binding of Pla2g1b and Phax 1 0.03 0 0.15
47 INT146744 Binding of NR3C1 and PLA2G4A 1 0.26 0.25 0.15
48 INT80139 PLA2G2A Positive_regulation of Gene_expression of TBXA2R 1 0.30 0.15 0.14
49 INT334770 Ednra Positive_regulation of Pla2g4a 1 0.00 0.24 0.14
50 INT146743 Positive_regulation of Binding of GSR and PLA2G4A 1 0.40 0.14 0.11
51 INT146742 Binding of GSR and PLA2G4A 1 0.28 0.14 0.11
52 INT223747 Tlr4 Positive_regulation of Pla2g1b 1 0.13 0 0.1
53 INT327557 Pla2g4a Positive_regulation of Phosphorylation of Ptgs2 1 0.14 1.03 0.1
54 INT110220 Pla2g2a Positive_regulation of Gene_expression of Ptafr 1 0.11 0.5 0.09
55 INT110219 Pla2g1b Positive_regulation of Gene_expression of Ptafr 1 0.17 0.5 0.09
56 INT327559 Pla2g4a Positive_regulation of Gene_expression of Ptgs2 1 0.14 1 0.09
57 INT197777 Pla2g10 Regulation of Pla2g2a 1 0.02 0.61 0.08
58 INT197776 Pla2g10 Regulation of Pla2g4a 1 0.18 0.61 0.08
59 INT234606 Tlr4 Positive_regulation of Transcription of PLA2G4A 1 0.57 0 0.06
60 INT177350 Binding of CEL and PLA2G2A 1 0.06 0.08 0.04
61 INT249199 CA2 Positive_regulation of PLA2G4A 1 0.15 0 0.04
62 INT195837 Tlr4 Positive_regulation of Pla2g4a 1 0.01 0.44 0.03
63 INT348362 Binding of C2 and Positive_regulation of Localization of PLA2G4A 1 0.02 0.37 0.03
64 INT229814 Fos Positive_regulation of Pla2g1b 1 0.12 0.27 0
65 INT320877 Agtr2 Positive_regulation of Pla2g2a 1 0.10 0.67 0
66 INT249179 PLA2G4A Regulation of CYBB 1 0.18 0 0
67 INT180853 Binding of PLA2G1B and S100A10 1 0.08 0.75 0
68 INT320878 Positive_regulation of Agtr2 Positive_regulation of Pla2g2a 1 0.10 0.67 0
69 INT249191 CYBB Positive_regulation of PLA2G4A 1 0.20 0 0
70 INT249187 Binding of CYBB and PLA2G4A 1 0.14 0 0
71 INT194268 Binding of PLA2G2A and NHP2 1 0.00 0 0
72 INT354513 Binding of Pla2g2a and Tes 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for calcium-dependent phospholipase A2 activity. They are ordered first by their pain relevance and then by number of times they were reported in calcium-dependent phospholipase A2 activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT113399 Positive_regulation of Pla2g4a 36 0.67 33.83 18.78
2 INT187513 Positive_regulation of Pla2g4a 5 0.62 34.09 18.22
3 INT1060 Negative_regulation of Pla2g1b 50 0.57 22.91 18.12
4 INT195831 Phosphorylation of Pla2g4a 15 0.74 34.43 17.14
5 INT3597 Positive_regulation of Pla2g1b 37 0.63 17.94 11.41
6 INT270238 Localization of Pla2g4a 1 0.72 17.99 11.35
7 INT17826 Positive_regulation of Pla2g1b 39 0.70 11.35 10.97
8 INT6574 Negative_regulation of Pla2g1b 35 0.59 11.4 10.44
9 INT86813 Gene_expression of Pla2g4a 26 0.75 42.31 10.07
10 INT45209 Positive_regulation of PLA2G2A 37 0.69 33.21 9.02
11 INT4021 Positive_regulation of PLA2G1B 35 0.70 23.27 8.2
12 INT7125 Gene_expression of PLA2G2A 47 0.78 42.12 7.83
13 INT4022 Negative_regulation of PLA2G1B 30 0.59 10.41 7.58
14 INT21613 Gene_expression of Pla2g1b 25 0.68 9.05 6.39
15 INT5254 Positive_regulation of Pla2g2a 22 0.68 10.42 6.37
16 INT60032 Negative_regulation of Pla2g2a 29 0.58 12.42 5.75
17 INT7126 Negative_regulation of PLA2G2A 26 0.58 12.97 5.64
18 INT17828 Gene_expression of Pla2g1b 18 0.70 6.22 5.58
19 INT7130 Localization of PLA2G2A 32 0.80 20.4 5.05
20 INT10504 Localization of Pla2g1b 18 0.65 8.19 5.05
21 INT91225 Positive_regulation of Pla2g2a 22 0.57 14.77 5.01
22 INT25334 Negative_regulation of Pla2g2a 16 0.56 9.01 4.23
23 INT64864 Gene_expression of PLA2G4A 18 0.77 10.45 4.09
24 INT3598 Regulation of Pla2g1b 12 0.44 3.45 3.9
25 INT162125 Gene_expression of Pla2g4a 4 0.54 7.69 3.75
26 INT14837 Gene_expression of PLA2G1B 12 0.60 10.69 3.58
27 INT25990 Positive_regulation of Pla2g5 11 0.69 4.93 3.32
28 INT270224 Positive_regulation of Positive_regulation of Pla2g4a 1 0.62 6.63 3.22
29 INT6578 Regulation of Pla2g1b 11 0.49 3.94 3.19
30 INT47729 Positive_regulation of Positive_regulation of Pla2g1b 3 0.08 3.65 3.07
31 INT43948 Localization of PLA2G1B 17 0.78 6.92 2.99
32 INT126172 Negative_regulation of Pla2g4a 7 0.39 9.01 2.89
33 INT59245 Localization of Pla2g1b 10 0.75 4.72 2.76
34 INT7127 Positive_regulation of Gene_expression of PLA2G2A 16 0.69 17.11 2.63
35 INT86815 Gene_expression of Pla2g2a 18 0.55 5.72 2.59
36 INT122376 Localization of Pla2g4a 12 0.73 7.18 2.58
37 INT86625 Binding of Pla2g1b 8 0.24 2.52 2.43
38 INT270235 Negative_regulation of Phosphorylation of Pla2g4a 1 0.39 3.4 2.34
39 INT17961 Regulation of Pla2g4a 9 0.25 4.86 2.3
40 INT152076 Negative_regulation of Pla2g4a 3 0.55 3.22 2.21
41 INT40817 Positive_regulation of Gene_expression of Pla2g1b 5 0.26 1.98 2.19
42 INT86814 Transcription of Pla2g4a 4 0.49 2.35 2.14
43 INT195828 Positive_regulation of Phosphorylation of Pla2g4a 3 0.45 5.05 2.12
44 INT79816 Localization of Pla2g2a 13 0.74 8.08 2.06
45 INT198095 Transcription of PLA2G2A 12 0.68 8.25 2.04
46 INT78773 Regulation of PLA2G2A 11 0.61 9.76 1.91
47 INT59244 Regulation of Pla2g2a 5 0.57 3.02 1.82
48 INT59248 Positive_regulation of Localization of Pla2g1b 4 0.47 2.27 1.81
49 INT25988 Negative_regulation of Pla2g5 5 0.58 2.68 1.68
50 INT91773 Positive_regulation of PLA2G4A 10 0.50 4.4 1.54
51 INT91764 Positive_regulation of Gene_expression of PLA2G4A 8 0.69 5.43 1.52
52 INT17827 Positive_regulation of Gene_expression of Pla2g1b 6 0.61 1.69 1.5
53 INT270223 Negative_regulation of Localization of Pla2g4a 1 0.39 1.83 1.5
54 INT25020 Gene_expression of Pla2g2a 11 0.76 5.97 1.48
55 INT268619 Phosphorylation of Pla2g4a 5 0.69 2.14 1.36
56 INT85868 Transcription of Pla2g1b 1 0.62 1.47 1.28
57 INT86812 Negative_regulation of Transcription of Pla2g4a 1 0.13 0.49 1.18
58 INT25336 Localization of Pla2g2a 5 0.72 4.97 1.17
59 INT50494 Phosphorylation of Pla2g1b 4 0.29 1.39 1.17
60 INT28674 Negative_regulation of Gene_expression of Pla2g1b 3 0.40 2.36 1.16
61 INT113398 Transcription of Pla2g2a 3 0.19 1.64 1.14
62 INT64863 Localization of PLA2G4A 9 0.44 3.33 1.07
63 INT150473 Binding of Pla2g2a 5 0.35 5.41 1.03
64 INT198098 Positive_regulation of Transcription of PLA2G2A 4 0.46 4.12 1.02
65 INT41729 Negative_regulation of Positive_regulation of PLA2G1B 3 0.43 2.7 1.02
66 INT195832 Regulation of Phosphorylation of Pla2g4a 3 0.34 2.91 1.02
67 INT162126 Positive_regulation of Gene_expression of Pla2g4a 4 0.42 2.52 1.01
68 INT229911 Regulation of Gene_expression of Pla2g1b 2 0.16 1.9 0.98
69 INT91762 Positive_regulation of Gene_expression of PLA2G1B 3 0.17 3.45 0.97
70 INT65166 Negative_regulation of PLA2G4A 7 0.57 1.55 0.96
71 INT112550 Positive_regulation of Positive_regulation of Pla2g1b 3 0.49 0.48 0.94
72 INT86816 Negative_regulation of Gene_expression of Pla2g4a 3 0.50 2.27 0.93
73 INT270236 Regulation of Localization of Pla2g4a 1 0.24 1.68 0.93
74 INT270231 Regulation of Positive_regulation of Pla2g4a 1 0.24 1.92 0.92
75 INT205888 Positive_regulation of Gene_expression of Pla2g4a 7 0.67 8 0.9
76 INT168990 Positive_regulation of Positive_regulation of Pla2g4a 2 0.43 2.14 0.86
77 INT77928 Binding of Pla2g4a 3 0.10 2.5 0.84
78 INT270226 Negative_regulation of Positive_regulation of Pla2g4a 1 0.38 2.34 0.84
79 INT146746 Transcription of PLA2G4A 3 0.69 1.03 0.8
80 INT6579 Regulation of Negative_regulation of Pla2g1b 2 0.21 0.08 0.79
81 INT56082 Negative_regulation of Positive_regulation of Pla2g2a 1 0.01 0.6 0.73
82 INT113400 Positive_regulation of Transcription of Pla2g4a 1 0.08 0.96 0.7
83 INT117268 Binding of PLA2G2A 4 0.42 1.99 0.68
84 INT308475 Regulation of Positive_regulation of Pla2g4a 1 0.09 1.14 0.67
85 INT166120 Gene_expression of Pla2g5 3 0.43 1.54 0.64
86 INT4020 Regulation of PLA2G1B 2 0.61 0.19 0.64
87 INT44788 Negative_regulation of Positive_regulation of Pla2g1b 1 0.20 0.09 0.64
88 INT261810 Positive_regulation of Positive_regulation of Pla2g5 1 0.08 0.25 0.62
89 INT66761 Negative_regulation of Gene_expression of Pla2g1b 2 0.42 0.35 0.6
90 INT126222 Positive_regulation of Binding of Pla2g1b 1 0.25 0.19 0.58
91 INT34356 Binding of Pla2g1b 1 0.35 0 0.57
92 INT270227 Positive_regulation of Localization of Pla2g4a 1 0.45 1.31 0.56
93 INT113397 Negative_regulation of Transcription of Pla2g1b 1 0.03 0.88 0.56
94 INT78775 Regulation of PLA2G4A 4 0.25 1.45 0.55
95 INT113401 Transcription of Pla2g1b 1 0.04 0.86 0.55
96 INT142108 Positive_regulation of Localization of Pla2g1b 2 0.08 1.71 0.53
97 INT76858 Binding of PLA2G4A 4 0.30 1.22 0.52
98 INT198092 Positive_regulation of Localization of PLA2G2A 2 0.50 0.98 0.51
99 INT136026 Transcription of Pla2g2a 1 0.05 0.51 0.5
100 INT222934 Regulation of Negative_regulation of Pla2g2a 1 0.21 1.51 0.49
101 INT270229 Binding of Pla2g4a 1 0.29 1.23 0.45
102 INT81694 Regulation of Positive_regulation of Pla2g2a 1 0.43 0 0.44
103 INT189050 Regulation of Pla2g2a 6 0.23 4.66 0.38
104 INT198099 Negative_regulation of Positive_regulation of PLA2G2A 2 0.42 2.58 0.38
105 INT248153 Phosphorylation of PLA2G4A 1 0.20 0.65 0.38
106 INT126173 Negative_regulation of Regulation of Pla2g4a 1 0.40 1.01 0.37
107 INT198094 Regulation of Gene_expression of PLA2G2A 3 0.45 2.19 0.35
108 INT34820 Negative_regulation of Negative_regulation of Pla2g1b 1 0.35 0.42 0.35
109 INT59247 Negative_regulation of Localization of Pla2g2a 2 0.39 1.27 0.34
110 INT59246 Regulation of Localization of Pla2g2a 1 0.41 0.49 0.34
111 INT126174 Positive_regulation of Regulation of Pla2g4a 1 0.37 1.03 0.34
112 INT205894 Regulation of Gene_expression of Pla2g4a 3 0.52 1.9 0.33
113 INT25335 Positive_regulation of Positive_regulation of Pla2g2a 3 0.21 0.8 0.33
114 INT79251 Regulation of Positive_regulation of PLA2G2A 1 0.27 0.35 0.33
115 INT146747 Negative_regulation of Gene_expression of PLA2G4A 1 0.43 0.66 0.33
116 INT198097 Regulation of Regulation of PLA2G2A 1 0.27 0.74 0.31
117 INT126171 Negative_regulation of Positive_regulation of Pla2g4a 1 0.39 0.91 0.27
118 INT312524 Positive_regulation of Transcription of Pla2g2a 1 0.05 0.62 0.26
119 INT123399 Positive_regulation of Positive_regulation of PLA2G1B 1 0.15 0.47 0.26
120 INT75639 Binding of Pla2g5 1 0.48 0.71 0.26
121 INT77020 Negative_regulation of Positive_regulation of Pla2g1b 1 0.06 0.32 0.24
122 INT25337 Positive_regulation of Localization of Pla2g2a 1 0.05 0.36 0.24
123 INT198096 Positive_regulation of Positive_regulation of PLA2G2A 1 0.50 0.84 0.23
124 INT25021 Positive_regulation of Gene_expression of Pla2g2a 3 0.68 0.83 0.22
125 INT129507 Regulation of Positive_regulation of Pla2g1b 1 0.42 0.1 0.22
126 INT70436 Negative_regulation of Negative_regulation of Pla2g1b 1 0.01 0 0.22
127 INT312523 Negative_regulation of Phosphorylation of Pla2g4a 1 0.16 0.68 0.22
128 INT173345 Phosphorylation of PLA2G1B 1 0.05 0 0.22
129 INT312522 Positive_regulation of Phosphorylation of Pla2g4a 1 0.14 0.68 0.21
130 INT157158 Positive_regulation of Localization of Pla2g2a 1 0.50 0.31 0.21
131 INT74514 Binding of PLA2G1B 2 0.48 0.37 0.19
132 INT197773 Binding of Pla2g2a 1 0.03 0.65 0.19
133 INT262261 Negative_regulation of Gene_expression of PLA2G1B 1 0.05 1.07 0.18
134 INT146748 Positive_regulation of Transcription of PLA2G4A 1 0.50 0.22 0.17
135 INT298482 Regulation of Negative_regulation of Pla2g1b 1 0.02 0.33 0.16
136 INT242223 Protein_catabolism of PLA2G2A 1 0.85 0.99 0.16
137 INT195826 Negative_regulation of Gene_expression of Pla2g4a 1 0.28 1.38 0.15
138 INT195829 Regulation of Pla2g4a 1 0.20 2.54 0.15
139 INT198100 Negative_regulation of Gene_expression of PLA2G2A 1 0.42 0.58 0.14
140 INT84395 Protein_catabolism of Pla2g4a 1 0.02 0.41 0.12
141 INT50495 Regulation of Positive_regulation of Pla2g1b 1 0.05 0.06 0.11
142 INT242228 Positive_regulation of Regulation of PLA2G2A 1 0.45 0.59 0.09
143 INT266664 Positive_regulation of Localization of PLA2G1B 1 0.12 0.32 0.08
144 INT189049 Positive_regulation of Negative_regulation of Pla2g2a 1 0.09 0 0.07
145 INT253445 Positive_regulation of Binding of Pla2g4a 1 0.12 0.91 0.06
146 INT320872 Positive_regulation of Gene_expression of Pla2g2a 5 0.39 0.86 0.05
147 INT133104 Regulation of Gene_expression of Pla2g2a 1 0.60 0.05 0.05
148 INT249275 Positive_regulation of Localization of PLA2G4A 1 0.25 0 0.04
149 INT71542 Protein_catabolism of Pla2g1b 2 0.96 0.6 0
150 INT143410 Regulation of Localization of PLA2G4A 2 0.34 0 0
151 INT320867 Regulation of Gene_expression of Pla2g2a 1 0.23 0.6 0
152 INT195830 Regulation of Regulation of Pla2g4a 1 0.20 0.62 0
153 INT213292 Positive_regulation of Protein_catabolism of Pla2g1b 1 0.02 0.52 0
154 INT292350 Protein_catabolism of Pla2g1b 1 0.07 0 0
155 INT189051 Regulation of Negative_regulation of Pla2g2a 1 0.07 0.29 0
156 INT337080 Positive_regulation of Localization of Pla2g4a 1 0.18 1 0
157 INT320868 Negative_regulation of Positive_regulation of Pla2g2a 1 0.22 0.66 0
158 INT190230 Positive_regulation of Positive_regulation of Pla2g2a 1 0.06 0.64 0
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