GO:0047555

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Name 3',5'-cyclic-GMP phosphodiesterase activity
Categary Function
Go Slim No
Go Link GO:0047555
Unique Molecular Interactions 103
Total Molecular Interactions 118
Total Single Events 1257
Pain Genes Associated 7

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for 3',5'-cyclic-GMP phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported for 3',5'-cyclic-GMP phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT291578 Negative_regulation of Pde12 Positive_regulation of Pde5a 1 0.03 1.11 1.67
2 INT291583 GUCY2C Regulation of Pde5a 1 0.00 1.12 1.45
3 INT128776 Cntn1 Positive_regulation of Gene_expression of Pde6b 1 0.02 0.55 1.26
4 INT152428 Ghrh Positive_regulation of Pde6b 1 0.07 0.5 1.18
5 INT55564 Binding of Oprk1 and Pde6b 1 0.01 0 0.92
6 INT257304 Pde5a Positive_regulation of Oprd1 1 0.15 0.48 0.89
7 INT221257 Pde5a Positive_regulation of PRKG1 3 0.07 0.19 0.86
8 INT291581 Pde5a Regulation of Localization of Abat 1 0.03 0 0.83
9 INT257222 Binding of Ltp and Pde5a 2 0.07 0.14 0.75
10 INT257302 Cnp Regulation of Protein_catabolism of Pde5a 1 0.05 0.49 0.7
11 INT291579 Pde12 Regulation of Binding of Pde5a 1 0.02 0.41 0.6
12 INT94089 Binding of Pnoc and Pde6b 1 0.02 0.09 0.57
13 INT291580 Pde5a Regulation of Abat 1 0.04 0.39 0.48
14 INT94092 Pnoc Positive_regulation of Pde6b 1 0.02 0.1 0.44
15 INT152430 Regulation of Ghrh Positive_regulation of Pde6b 1 0.04 0.16 0.43
16 INT257229 Binding of PRKG1 and Pde5a 1 0.01 0.17 0.41
17 INT275099 Pde9a Negative_regulation of RTP3 1 0.00 0.51 0.39
18 INT275093 Pde9a Negative_regulation of stm 1 0.00 0.51 0.39
19 INT152426 Ghrh Positive_regulation of Positive_regulation of Pde6b 1 0.07 0.14 0.38
20 INT221259 Pde5a Positive_regulation of Localization of PRKG1 1 0.00 0.06 0.37
21 INT275096 Pde9a Regulation of Ltp 1 0.00 0.11 0.35
22 INT275098 Pde9a Regulation of RTP3 1 0.00 0.11 0.35
23 INT275094 Pde5a Regulation of Ltp 1 0.05 0 0.35
24 INT316929 Pde5a Regulation of Ephb1 1 0.03 0.17 0.27
25 INT280181 Pde5a Positive_regulation of Regulation of Cpox 1 0.00 0.16 0.26
26 INT257224 Pde5a Positive_regulation of Phosphorylation of Creb1 1 0.03 0.09 0.2
27 INT163055 Negative_regulation of Pde10a Positive_regulation of Gene_expression of Qrfp 1 0.03 0 0.2
28 INT32162 POMC Negative_regulation of PDE11A 1 0.23 0 0.19
29 INT202297 Pde5a Positive_regulation of Prkg1 1 0.00 0.13 0.18
30 INT263180 Binding of PDE5A and COPD 1 0.01 1 0.15
31 INT263175 PDE5A Regulation of COPD 1 0.00 1 0.15
32 INT273017 Binding of PDE1B and PDE11A 1 0.08 0.35 0.14
33 INT273020 Binding of FGF9 and PDE11A 1 0.22 0.3 0.11
34 INT257217 Binding of Pde2a and Pde5a 1 0.03 0 0.1
35 INT257221 Negative_regulation of Binding of Src and Pde5a 1 0.03 0 0.08
36 INT257219 Binding of Src and Pde5a 1 0.02 0 0.08
37 INT222489 Npr2 Positive_regulation of Pde5a 1 0.00 0.16 0.07
38 INT222429 Nps Positive_regulation of Pde5a 1 0.00 0.16 0.07
39 INT337608 Pde5a Regulation of Cnga1 1 0.00 0 0.04
40 INT263197 Binding of PDE3A and Pde5a 1 0.03 0.18 0.04
41 INT275090 Twist1 Positive_regulation of Gene_expression of Pde5a 1 0.02 0.62 0.04
42 INT275095 Twist1 Positive_regulation of Pde5a 1 0.03 0.62 0.04
43 INT263198 Pde5a Negative_regulation of PDE4A 1 0.09 0.16 0.03
44 INT331897 Binding of PDE5A and Pde5a 1 0.02 0.64 0.03
45 INT222556 Pde5a Regulation of Localization of LH 1 0.00 0.06 0
46 INT313871 Pde5a Positive_regulation of Pah 1 0.49 0.97 0
47 INT209159 Binding of LHCGR and PDE5A 1 0.01 0 0
48 INT191577 Binding of Pde6b and Tst 1 0.02 0.48 0
49 INT263181 Binding of Pde1a and Pde5a 1 0.03 0 0
50 INT275091 Negative_regulation of Twist1 Positive_regulation of Pde5a 1 0.02 0.06 0
51 INT242674 Binding of Pde6b and Ppp3cb 1 0.00 0.6 0
52 INT98236 LOC360919 Positive_regulation of Pde5a 1 0.00 0.33 0
53 INT268021 Pde5a Positive_regulation of Kcnj5 1 0.01 0 0
54 INT263183 Binding of Pde1b and Pde5a 1 0.03 0 0
55 INT268052 Pde5a Positive_regulation of Positive_regulation of PRKG1 1 0.00 0 0
56 INT268022 Pde5a Positive_regulation of Gene_expression of Kcnj5 1 0.01 0 0
57 INT343716 Nos3 Positive_regulation of Pde6b 1 0.20 0 0
58 INT222471 Gnrh1 Positive_regulation of Pde5a 1 0.00 0.07 0
59 INT98235 Pde5a Negative_regulation of Pdpk1 1 0.00 0.32 0
60 INT343718 Nos3 Regulation of Pde6b 1 0.10 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported for 3',5'-cyclic-GMP phosphodiesterase activity. They are ordered first by their pain relevance and then by number of times they were reported in 3',5'-cyclic-GMP phosphodiesterase activity. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT76336 Negative_regulation of PDE5A 192 0.59 112.02 20.09
2 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65
3 INT209 Positive_regulation of Pde5a 30 0.21 2.54 16.31
4 INT94861 Gene_expression of Pde5a 40 0.69 14.73 13.27
5 INT48009 Gene_expression of Pde6b 38 0.68 15.03 11.41
6 INT94859 Negative_regulation of Pde5a 67 0.43 33.66 10.28
7 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14
8 INT160168 Gene_expression of Pde10a 10 0.74 8.66 7.94
9 INT94862 Positive_regulation of Gene_expression of Pde5a 10 0.20 4.23 5.18
10 INT73128 Regulation of Pde5a 7 0.37 4.42 4.27
11 INT119498 Positive_regulation of Pde6b 11 0.43 18.75 4.22
12 INT48008 Negative_regulation of Pde6b 9 0.15 6.12 4.11
13 INT73127 Gene_expression of Pde5a 18 0.76 5.25 3.31
14 INT131472 Regulation of Pde5a 11 0.42 6.95 3.06
15 INT136675 Transcription of Pde5a 6 0.63 4.74 2.71
16 INT92877 Gene_expression of PDE5A 35 0.76 17.1 2.7
17 INT94860 Negative_regulation of Gene_expression of Pde5a 2 0.33 3.2 2.64
18 INT257298 Regulation of Positive_regulation of Pde5a 1 0.19 2.03 2.54
19 INT128773 Regulation of Gene_expression of Pde6b 4 0.45 1.41 2.5
20 INT257299 Binding of Pde5a 14 0.27 4.31 2.45
21 INT257301 Protein_catabolism of Pde5a 5 0.30 1.97 2.26
22 INT48007 Regulation of Pde6b 6 0.39 4.4 2.2
23 INT108422 Binding of Pde5a 11 0.36 3.07 2.07
24 INT165648 Negative_regulation of Transcription of Pde5a 1 0.41 3.6 1.93
25 INT24909 Negative_regulation of Pde10a 4 0.43 0.87 1.87
26 INT291576 Positive_regulation of Protein_catabolism of Pde5a 1 0.12 1.15 1.43
27 INT73126 Positive_regulation of Gene_expression of Pde5a 3 0.59 0.55 1.31
28 INT242945 Localization of PDE5A 9 0.75 4.57 1.28
29 INT79598 Regulation of PDE5A 16 0.60 8.68 1.17
30 INT103043 Binding of PDE5A 16 0.37 7.79 1.12
31 INT160171 Localization of Pde10a 2 0.77 1.26 0.95
32 INT257200 Phosphorylation of Pde5a 1 0.25 0 0.94
33 INT165644 Regulation of Transcription of Pde5a 1 0.44 1.65 0.91
34 INT164144 Phosphorylation of Pde5a 4 0.19 1.15 0.87
35 INT177532 Localization of Pde5a 2 0.56 0.96 0.81
36 INT165645 Positive_regulation of Negative_regulation of Pde5a 3 0.37 1.58 0.74
37 INT165647 Negative_regulation of Negative_regulation of Pde5a 1 0.31 1.22 0.67
38 INT257202 Protein_catabolism of Pde5a 2 0.38 0.36 0.66
39 INT165646 Positive_regulation of Transcription of Pde5a 1 0.33 1.21 0.66
40 INT208 Negative_regulation of Positive_regulation of Pde5a 3 0.17 2.02 0.65
41 INT275071 Negative_regulation of Protein_catabolism of Pde5a 1 0.17 0.36 0.6
42 INT242944 Negative_regulation of Localization of PDE5A 3 0.35 3.18 0.59
43 INT275078 Negative_regulation of Pde9a 1 0.01 1.38 0.57
44 INT126754 Binding of Pde6b 5 0.34 1.34 0.55
45 INT94088 Transcription of Pde6b 2 0.55 0.39 0.53
46 INT257211 Negative_regulation of Localization of Pde5a 1 0.13 0.2 0.48
47 INT291577 Positive_regulation of Phosphorylation of Pde5a 1 0.12 0.35 0.48
48 INT152425 Positive_regulation of Positive_regulation of Pde6b 2 0.18 1.74 0.46
49 INT130371 Negative_regulation of Gene_expression of PDE5A 3 0.43 1.59 0.45
50 INT119499 Regulation of Positive_regulation of Pde6b 2 0.11 0.8 0.43
51 INT79597 Positive_regulation of Negative_regulation of PDE5A 5 0.50 3.39 0.41
52 INT275079 Positive_regulation of Pde9a 1 0.01 0 0.41
53 INT130372 Transcription of PDE5A 7 0.72 1.93 0.4
54 INT79599 Protein_catabolism of PDE5A 7 1.00 3.16 0.39
55 INT275077 Protein_catabolism of Pde9a 1 0.01 0.05 0.35
56 INT275068 Negative_regulation of Protein_catabolism of Pde9a 1 0.01 0.05 0.35
57 INT275073 Positive_regulation of Negative_regulation of Pde5a 1 0.22 0.45 0.3
58 INT117995 Regulation of Negative_regulation of PDE5A 3 0.44 2.4 0.29
59 INT273021 Binding of PDE11A 1 0.35 0.78 0.26
60 INT183429 Localization of Pde5a 5 0.56 1.61 0.25
61 INT303483 Positive_regulation of PDE5A 2 0.39 1.5 0.23
62 INT249115 Localization of Pde6b 6 0.68 1.09 0.21
63 INT261276 Positive_regulation of Positive_regulation of Pde5a 1 0.26 0.07 0.21
64 INT42375 Positive_regulation of Positive_regulation of Pde5a 2 0.14 0.1 0.19
65 INT32164 Positive_regulation of PDE11A 1 0.26 0 0.19
66 INT261275 Negative_regulation of Localization of Pde5a 2 0.31 1.11 0.18
67 INT42376 Regulation of Positive_regulation of Pde5a 1 0.03 0 0.18
68 INT163053 Regulation of Negative_regulation of Pde10a 1 0.45 0 0.18
69 INT343714 Negative_regulation of Positive_regulation of Pde6b 1 0.15 1.87 0.17
70 INT275082 Regulation of Pde9a 1 0.00 0.28 0.16
71 INT213222 Negative_regulation of Protein_catabolism of PDE5A 1 0.24 0.65 0.16
72 INT177528 Negative_regulation of Binding of Pde5a 1 0.34 0.46 0.15
73 INT263121 Negative_regulation of Negative_regulation of PDE5A 2 0.43 1.33 0.14
74 INT242949 Phosphorylation of PDE5A 2 0.68 0.05 0.13
75 INT275069 Negative_regulation of Gene_expression of Pde5a 1 0.26 0.54 0.13
76 INT273022 Negative_regulation of PDE11A 1 0.40 0.24 0.11
77 INT303482 Positive_regulation of Protein_catabolism of PDE5A 1 0.20 1.27 0.1
78 INT261274 Negative_regulation of Protein_catabolism of Pde5a 1 0.20 0.18 0.09
79 INT257205 Transcription of Pde5a 1 0.21 0 0.08
80 INT343709 Positive_regulation of Negative_regulation of Pde6b 1 0.16 0.87 0.06
81 INT213216 Positive_regulation of Gene_expression of PDE5A 2 0.37 2.08 0.04
82 INT266216 Negative_regulation of Localization of Pde6b 1 0.39 0 0.04
83 INT183435 Regulation of Localization of Pde5a 1 0.34 0.35 0.04
84 INT183437 Regulation of Pde10a 1 0.05 0.4 0.04
85 INT323262 Negative_regulation of Negative_regulation of Pde5a 1 0.03 1.32 0.04
86 INT183438 Regulation of Localization of Pde10a 1 0.08 0.4 0.04
87 INT263185 Regulation of Gene_expression of Pde5a 1 0.12 0.19 0.03
88 INT275492 Positive_regulation of Gene_expression of Pde6b 3 0.50 0.12 0
89 INT269744 Negative_regulation of Binding of PDE5A 2 0.43 0.74 0
90 INT162907 Regulation of Gene_expression of PDE5A 2 0.51 0 0
91 INT269741 Positive_regulation of Localization of PDE5A 1 0.04 0.65 0
92 INT268038 Regulation of Negative_regulation of Pde5a 1 0.03 0 0
93 INT245698 Positive_regulation of Transcription of Pde6b 1 0.40 0.3 0
94 INT162909 Gene_expression of PDE11A 1 0.17 0 0
95 INT162922 Negative_regulation of Transcription of PDE5A 1 0.41 0 0
96 INT92876 Regulation of Protein_catabolism of PDE5A 1 0.45 0.71 0
97 INT162912 Regulation of Transcription of PDE5A 1 0.44 0 0
98 INT162915 Positive_regulation of Regulation of PDE5A 1 0.40 0 0
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