GO:0048009

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Name insulin-like growth factor receptor signaling pathway
Categary Process
Go Slim No
Go Link GO:0048009
Unique Molecular Interactions 1086
Total Molecular Interactions 1507
Total Single Events 10455
Pain Genes Associated 25

This page displays the top molecular interactions and top single events that were mentioned in the literature for cytoplasm. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 100 pain related interactions that have been reported for insulin-like growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported for insulin-like growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Pain Relevance
1 INT132225 Negative_regulation of Binding of Akt1 and Sh2d6 1 0.10 3.92 7.2
2 INT142177 Calca Positive_regulation of Gene_expression of Igf1 8 0.78 3.57 5.71
3 INT132231 Negative_regulation of Binding of Akt1 and Pik3cg 1 0.34 1.96 3.6
4 INT69823 Binding of GHR and RYBP 1 0.01 0 3.23
5 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13
6 INT168758 Hist1h1t Positive_regulation of Phosphorylation of Akt1 2 0.02 0.44 2.79
7 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74
8 INT121726 Ngf Positive_regulation of Phosphorylation of Akt1 1 0.37 1.4 2.34
9 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2
10 INT132229 Binding of Akt1 and Sh2d6 1 0.09 0.98 1.8
11 INT185143 Elane Positive_regulation of Pik3r1 1 0.01 0 1.72
12 INT169464 Akt1 Positive_regulation of Egfr 1 0.28 1.63 1.7
13 INT145826 Calca Positive_regulation of Gene_expression of Igf1 3 0.75 3.05 1.66
14 INT322412 PPBP Negative_regulation of Phosphorylation of Akt1 1 0.01 0 1.65
15 INT147652 PLCB1 Negative_regulation of Positive_regulation of TRPV1 1 0.27 0.92 1.62
16 INT112034 Gabrb3 Positive_regulation of Pik3r1 1 0.08 0.18 1.48
17 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44
18 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43
19 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41
20 INT69824 Negative_regulation of Binding of GHR and RYBP 1 0.01 0 1.14
21 INT317548 Positive_regulation of Akt1 Positive_regulation of Prkca 1 0.15 0 1.11
22 INT317516 Binding of Oprm1 and Negative_regulation of Positive_regulation of Akt1 1 0.17 0.1 1.11
23 INT323175 PRKCA Positive_regulation of Akt1 1 0.02 0 1.1
24 INT108547 AKT1 Regulation of MAPKAPK5 1 0.04 1.2 1.08
25 INT151218 Negative_regulation of SIGMAR1 Negative_regulation of Positive_regulation of Akt1 1 0.00 0.26 1.03
26 INT106345 Igf1 Regulation of Localization of Acot1 1 0.06 0 1.02
27 INT12141 Igf1 Negative_regulation of Chat 1 0.32 0.63 1
28 INT317554 Akt1 Regulation of Negative_regulation of Oprm1 1 0.21 0.07 1
29 INT317564 Pik3r1 Regulation of Negative_regulation of Oprm1 1 0.13 0.07 1
30 INT317567 Binding of Akt1 and Nos1 1 0.22 0 0.96
31 INT137923 VEGFA Positive_regulation of Phosphorylation of Akt1 1 0.05 0 0.93
32 INT45279 Binding of CSF2 and GHR 1 0.05 0.07 0.93
33 INT114883 Akt1 Regulation of Pik3r1 2 0.16 0.65 0.92
34 INT317541 Oprd1 Negative_regulation of Akt1 1 0.06 0 0.91
35 INT249012 Binding of Akt1 and Gabrg1 1 0.01 0 0.9
36 INT132226 Binding of Akt1 and Pik3cg 1 0.30 0.49 0.9
37 INT199109 Binding of Akt1 and Arhgdia 1 0.02 2.73 0.87
38 INT116106 VEGFA Positive_regulation of AKT1 1 0.12 0.3 0.83
39 INT317556 Phosphorylation of Gopc Positive_regulation of Akt1 1 0.10 0.08 0.82
40 INT317514 Akt1 Regulation of Localization of Oprm1 1 0.21 0.07 0.82
41 INT73775 Binding of GH1 and GHR 4 0.35 0.68 0.8
42 INT228255 Binding of Akt1 and Pten 2 0.43 1.78 0.8
43 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8
44 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8
45 INT181616 INS Positive_regulation of IRS1 1 0.01 1 0.79
46 INT111888 Akt1 Regulation of Regulation of Oprm1 1 0.04 0 0.77
47 INT181615 SRC Positive_regulation of IRS1 1 0.01 0.98 0.77
48 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76
49 INT73776 Regulation of Binding of GH1 and GHR 2 0.26 0.16 0.75
50 INT335592 Ltp Positive_regulation of Positive_regulation of Akt1 1 0.01 0.19 0.74
51 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74
52 INT276213 Pten Regulation of Phosphorylation of Akt1 1 0.51 0.61 0.72
53 INT317573 Binding of Oprm1 and Pik3r1 1 0.12 0.33 0.71
54 INT8980 Gal Regulation of PLCB1 1 0.18 0.13 0.68
55 INT298728 Akt1 Positive_regulation of Rela 1 0.01 1.03 0.67
56 INT289357 Ngfr Positive_regulation of Akt1 1 0.03 3.1 0.66
57 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65
58 INT296793 Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.75 0.65
59 INT296791 Positive_regulation of Akt1 Positive_regulation of Gene_expression of Bax 1 0.11 0.8 0.65
60 INT317560 Binding of Pdpk1 and Pik3r1 1 0.13 0 0.65
61 INT309664 Binding of Pik3r1 and Cia1 1 0.02 1.32 0.64
62 INT169293 PTPLA Positive_regulation of AKT1 1 0.10 0.15 0.64
63 INT116752 Ngf Regulation of Pik3r1 1 0.56 0.29 0.63
64 INT134047 Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
65 INT134044 Positive_regulation of Fitm1 Positive_regulation of Phosphorylation of Akt1 1 0.05 0.21 0.63
66 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62
67 INT200808 Binding of Akt1 and Insrr 2 0.00 0.98 0.61
68 INT282286 Akt1 Positive_regulation of Pak1 1 0.15 0.24 0.61
69 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6
70 INT248994 Binding of Akt1 and Ptar1 1 0.00 0 0.58
71 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58
72 INT156668 Gh Positive_regulation of Igf1 5 0.22 2.07 0.57
73 INT317639 Igf1 Regulation of Creb1 1 0.23 0.16 0.57
74 INT156667 Gh Positive_regulation of Gene_expression of Igf1 6 0.28 0.88 0.56
75 INT323176 PRKCA Positive_regulation of Phosphorylation of Akt1 1 0.02 0 0.56
76 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56
77 INT150291 Grk1 Positive_regulation of Gene_expression of Igf1 1 0.16 0.98 0.55
78 INT201944 CXCL10 Positive_regulation of Phosphorylation of AKT1 1 0.09 0.79 0.55
79 INT106347 Igf1 Regulation of Chat 1 0.44 0 0.55
80 INT114064 Agtr2 Positive_regulation of Phosphorylation of Akt1 1 0.24 0.41 0.54
81 INT282284 Cpox Positive_regulation of Akt1 1 0.02 0.47 0.54
82 INT282282 Ptger2 Positive_regulation of Akt1 1 0.03 0.47 0.54
83 INT162994 Binding of Akt1 and Trib3 1 0.04 0.09 0.54
84 INT127320 Gpx3 Regulation of Akt1 2 0.00 3.11 0.53
85 INT317523 Oprm1 Positive_regulation of Gene_expression of Akt1 1 0.32 0.05 0.53
86 INT109307 Pik3r1 Positive_regulation of Phosphorylation of Akt1 1 0.29 0.4 0.53
87 INT317574 Oprm1 Positive_regulation of Akt1 1 0.22 0.05 0.52
88 INT317565 Oprm1 Positive_regulation of Pik3r1 1 0.14 0.05 0.52
89 INT97952 Negative_regulation of NRP2 Negative_regulation of Positive_regulation of AKT1 1 0.03 0.72 0.51
90 INT151221 Negative_regulation of SIGMAR1 Negative_regulation of Akt1 1 0.00 0.13 0.51
91 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5
92 INT97951 ST3GAL3 Positive_regulation of AKT1 1 0.04 0.7 0.5
93 INT102844 Pdc Regulation of Akt1 1 0.03 0 0.49
94 INT108568 Calca Positive_regulation of Igf1 1 0.51 0.08 0.48
95 INT134042 Jak2 Regulation of Akt1 1 0.18 0.13 0.47
96 INT309126 Edc4 Positive_regulation of Akt1 1 0.02 0.99 0.47
97 INT309144 Dlat Positive_regulation of Akt1 1 0.03 0.99 0.47
98 INT276207 Binding of Akt1 and Myo1f 1 0.11 0.05 0.47
99 INT162932 TXNRD1 Negative_regulation of Phosphorylation of AKT1 1 0.14 1.01 0.47
100 INT114065 Akt1 Regulation of Gene_expression of Insr 1 0.13 0.28 0.46
101 INT280614 Il6 Regulation of Transcription of Irs1 1 0.26 0.4 0.46
102 INT276218 Binding of Akt1 and Pten 1 0.26 0.08 0.46
103 INT162929 NQO1 Negative_regulation of Phosphorylation of AKT1 1 0.41 1 0.46
104 INT348784 Ins1 Positive_regulation of Irs1 1 0.09 3.47 0.44
105 INT139900 Kcne2 Positive_regulation of Akt1 1 0.06 2.95 0.44
106 INT160047 PTEN Regulation of Gene_expression of AKT1 1 0.33 0.6 0.42
107 INT348785 Ins1 Positive_regulation of Phosphorylation of Akt1 1 0.17 3.5 0.42
108 INT322396 Hist1h1t Positive_regulation of Akt1 1 0.01 0 0.42
109 INT160048 INPPL1 Regulation of Gene_expression of AKT1 1 0.28 0.6 0.42
110 INT322395 Akt1 Regulation of Pik3cb 1 0.08 0 0.42
111 INT121851 AKT1 Regulation of ROS1 1 0.16 0.52 0.41
112 INT122749 Cyp3a23/3a1 Positive_regulation of Phosphorylation of Akt1 1 0.07 0.24 0.41
113 INT121848 AKT1 Regulation of CASP8 1 0.18 0.52 0.41
114 INT121854 AKT1 Regulation of BID 1 0.17 0.52 0.41
115 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4
116 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4
117 INT108197 AKT1 Regulation of JUN 1 0.29 0.25 0.4
118 INT231842 Pcdh8 Positive_regulation of Akt1 1 0.00 1.59 0.4
119 INT285725 Binding of IGF1R and INS 1 0.27 0.07 0.4
120 INT121853 Gene_expression of ROS1 Negative_regulation of AKT1 1 0.25 0.49 0.4
121 INT322409 Positive_regulation of OPRM1 Positive_regulation of Phosphorylation of Akt1 1 0.04 0 0.4
122 INT99304 Igf1 Positive_regulation of Gh1 1 0.44 0.39 0.39
123 INT166155 Ccr9 Positive_regulation of Akt1 1 0.58 2.14 0.39
124 INT166157 Ccr9 Positive_regulation of Pik3r1 1 0.55 2.14 0.39
125 INT146611 Ins1 Positive_regulation of Phosphorylation of Akt1 9 0.23 4.34 0.37
126 INT89386 INS Positive_regulation of Phosphorylation of AKT1 3 0.43 1.48 0.36
127 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36
128 INT272951 Binding of TNF and Igf1 1 0.14 1.48 0.36
129 INT272953 Negative_regulation of Binding of TNF and Igf1 1 0.16 1.48 0.36
130 INT63278 Gpm6a Regulation of Igf1 1 0.01 0 0.36
131 INT148243 Binding of Akt1 and Kit 1 0.03 0.44 0.35
132 INT272952 Igf1 Positive_regulation of Localization of TNF 1 0.19 1.53 0.35
133 INT122758 Positive_regulation of Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
134 INT288208 Binding of Mapk14 and Positive_regulation of Akt1 1 0.01 0.42 0.35
135 INT176135 AKT1 Regulation of Localization of CYCS 1 0.43 2.16 0.35
136 INT122756 Helt Positive_regulation of Akt1 1 0.00 0.2 0.35
137 INT309118 Dlat Positive_regulation of Positive_regulation of Akt1 1 0.03 0.32 0.34
138 INT277656 Igf1 Positive_regulation of Igfbp3 1 0.01 0.4 0.34
139 INT249019 Gabrg1 Positive_regulation of Akt1 1 0.02 0 0.34
140 INT196820 Negative_regulation of Ppp1cc Positive_regulation of Akt1 1 0.00 0 0.34
141 INT89381 INS Positive_regulation of AKT1 6 0.43 3.06 0.33
142 INT288200 Tlr2 Positive_regulation of Pik3r1 1 0.05 0.24 0.33
143 INT168779 Binding of Pik3r1 and Tnf 1 0.01 0.73 0.33
144 INT214377 Akt1 Regulation of Amph 1 0.15 0 0.33
145 INT165580 Binding of Akt1 and Grin2b 1 0.02 0.2 0.32
146 INT337410 AKT3 Negative_regulation of AKT1 1 0.09 0.49 0.32
147 INT337414 AKT2 Negative_regulation of AKT1 1 0.10 0.5 0.32
148 INT255740 Pik3r1 Positive_regulation of Akt1 5 0.24 2.42 0.31
149 INT303063 Akt1 Negative_regulation of Gene_expression of Syn1 1 0.09 0.45 0.31
150 INT165921 Tlr4 Positive_regulation of Akt1 1 0.16 0.75 0.31
151 INT165920 Negative_regulation of Tlr4 Positive_regulation of Akt1 1 0.13 0.75 0.31
152 INT65268 Igf1 Positive_regulation of Col7a1 1 0.48 0 0.3
153 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3
154 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3
155 INT122575 Akt1 Positive_regulation of Phosphorylation of Nos3 4 0.37 3.89 0.29
156 INT185141 Pik3r1 Positive_regulation of Snrpd1 1 0.00 0.16 0.29
157 INT323653 Binding of Igf1 and Igfbp1 1 0.20 1.14 0.29
158 INT291202 Positive_regulation of INS Positive_regulation of AKT1 1 0.01 0.76 0.29
159 INT246841 Binding of Irs1 and Ppp1r13b 5 0.16 0.94 0.28
160 INT132367 Lgals1 Positive_regulation of Akt1 1 0.22 0.13 0.28
161 INT317533 Akt1 Positive_regulation of Nos1 1 0.43 0 0.28
162 INT177476 Gnrhr Positive_regulation of Localization of Igf1 1 0.05 1.01 0.28
163 INT149322 Amph Positive_regulation of Akt1 1 0.39 0 0.27
164 INT50303 Igf1 Regulation of Localization of Gnrhr 1 0.05 0.09 0.27
165 INT223930 Binding of Akt1 and Pik3cb 1 0.07 0.35 0.26
166 INT296794 Positive_regulation of Tlr2 Positive_regulation of Pik3r1 1 0.10 1.02 0.26
167 INT223929 Negative_regulation of Binding of Akt1 and Pik3cb 1 0.08 0.36 0.26
168 INT303082 Akt1 Negative_regulation of Gene_expression of Mafk 1 0.20 0.37 0.26
169 INT308661 Akt1 Positive_regulation of Chuk 1 0.02 0.6 0.25
170 INT314047 THL Negative_regulation of Phosphorylation of Akt1 1 0.14 0.71 0.25
171 INT97188 Gh Positive_regulation of Localization of Igf1 1 0.02 0.54 0.25
172 INT157957 Ppyr1 Negative_regulation of Phosphorylation of PLCB1 1 0.00 0.24 0.24
173 INT130691 CA2 Positive_regulation of EIF2AK3 1 0.16 0.59 0.24
174 INT326094 Akt1 Positive_regulation of Gene_expression of Gopc 1 0.03 0.49 0.24
175 INT118857 PLCB1 Regulation of Phosphorylation of SRC 1 0.01 0.15 0.24
176 INT326092 Gene_expression of Akt1 Negative_regulation of Gopc 1 0.03 0.55 0.24
177 INT92581 IGF1R Positive_regulation of Gene_expression of PTGER2 1 0.09 0.79 0.24
178 INT326093 Akt1 Positive_regulation of Gopc 1 0.03 0.43 0.23
179 INT245590 Ghr Positive_regulation of Gene_expression of Igf1 1 0.34 0.61 0.23
180 INT265886 IGF1 Positive_regulation of AKT1 1 0.11 3.06 0.23
181 INT260835 NRP2 Positive_regulation of Eif2ak3 1 0.00 0.73 0.23
182 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22
183 INT323173 THRA Positive_regulation of Phosphorylation of Akt1 1 0.00 0 0.22
184 INT260844 NRP2 Positive_regulation of Akt1 1 0.00 0.73 0.22
185 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21
186 INT173946 Igf1 Regulation of Gene_expression of IGF1 1 0.08 0.68 0.21
187 INT173944 IGF1 Regulation of Gene_expression of Igf1 1 0.08 0.68 0.21
188 INT323174 DBT Positive_regulation of Phosphorylation of Akt1 1 0.01 0 0.21
189 INT120716 Binding of AKT1 and TEP1 1 0.05 0.46 0.21
190 INT116468 VEGFA Positive_regulation of Akt1 1 0.04 1.39 0.21
191 INT139454 Binding of IGF2R and Icam1 1 0.00 0.4 0.21
192 INT289356 Binding of Akt1 and Fgf2 1 0.03 0.82 0.21
193 INT309661 C5 Positive_regulation of Phosphorylation of Akt1 1 0.51 0.45 0.21
194 INT286070 Igf1 Regulation of Regulation of Ins1 1 0.10 1.7 0.2
195 INT221237 Prkca Regulation of Phosphorylation of Akt1 1 0.01 0.28 0.2
196 INT106825 Ednra Negative_regulation of Igf1 1 0.07 0.07 0.2
197 INT286071 Igf1 Regulation of Ins1 1 0.10 1.69 0.2
198 INT250537 Ptpn6 Negative_regulation of Igf1 1 0.08 0 0.2
199 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19
200 INT280621 Il6 Negative_regulation of Transcription of Irs1 1 0.25 0.4 0.19

Single Events

The table below shows the top 100 pain related interactions that have been reported for insulin-like growth factor receptor signaling pathway. They are ordered first by their pain relevance and then by number of times they were reported in insulin-like growth factor receptor signaling pathway. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Pain Relevance
1 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34
2 INT117713 Phosphorylation of Akt1 275 0.82 95.82 54.34
3 INT40777 Positive_regulation of Akt1 163 0.69 59.41 49.43
4 INT106525 Phosphorylation of Akt1 436 0.82 183.81 47.82
5 INT14559 Gene_expression of Igf1 254 0.78 112 34.17
6 INT8915 Gene_expression of Igf1 199 0.78 78.58 32.51
7 INT114881 Gene_expression of Akt1 227 0.78 102.49 31.81
8 INT112707 Negative_regulation of Akt1 89 0.59 28.85 27.76
9 INT122570 Negative_regulation of Akt1 173 0.59 91.44 25.53
10 INT40776 Gene_expression of Akt1 99 0.77 34.91 24.39
11 INT117718 Positive_regulation of Phosphorylation of Akt1 112 0.69 39.26 24.09
12 INT14556 Positive_regulation of Igf1 105 0.69 52.21 24.04
13 INT112029 Positive_regulation of Pik3r1 90 0.67 38.76 20.95
14 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61
15 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44
16 INT112027 Gene_expression of Pik3r1 58 0.75 30.9 15.95
17 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59
18 INT109031 Positive_regulation of Eif2ak3 44 0.69 21.11 14.72
19 INT65263 Positive_regulation of Gene_expression of Igf1 61 0.69 25.69 14.49
20 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19
21 INT109304 Positive_regulation of Phosphorylation of Akt1 113 0.69 40.92 13.49
22 INT17539 Positive_regulation of Igf1 68 0.69 28.47 13.02
23 INT114420 Negative_regulation of Pik3r1 67 0.54 34.86 12.82
24 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54
25 INT26534 Regulation of Akt1 34 0.61 14.47 11.86
26 INT75137 Regulation of Akt1 74 0.48 37.89 9.7
27 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99
28 INT120967 Negative_regulation of Phosphorylation of Akt1 47 0.57 23.67 8.98
29 INT104396 Positive_regulation of Positive_regulation of Akt1 44 0.55 14.78 8.69
30 INT3803 Negative_regulation of Igf1 45 0.58 15.95 7.98
31 INT106522 Negative_regulation of Phosphorylation of Akt1 65 0.58 34.44 7.83
32 INT103925 Negative_regulation of Positive_regulation of Akt1 32 0.58 15.19 7.39
33 INT126748 Positive_regulation of Positive_regulation of Akt1 26 0.55 11.15 7.08
34 INT142344 Transcription of Igf1 22 0.69 7.55 6.77
35 INT14560 Regulation of Igf1 41 0.59 19.59 6.3
36 INT9494 Positive_regulation of Gene_expression of Igf1 34 0.67 17.77 6.26
37 INT9495 Negative_regulation of Gene_expression of Igf1 31 0.59 11.87 6.1
38 INT9321 Transcription of Igf1 25 0.69 10.2 6.08
39 INT117721 Positive_regulation of Gene_expression of Akt1 22 0.69 6.26 6.08
40 INT114882 Positive_regulation of Gene_expression of Akt1 45 0.69 21.29 6.06
41 INT36757 Gene_expression of Eif2ak3 4 0.74 0.15 6.06
42 INT8916 Regulation of Igf1 45 0.60 13.06 5.81
43 INT151032 Localization of Igf1 49 0.76 26.32 5.71
44 INT9895 Binding of GHR 18 0.36 4.8 5.65
45 INT9325 Gene_expression of Igf1r 14 0.77 8.74 5.48
46 INT116744 Binding of Pik3r1 22 0.36 12.77 5.01
47 INT105336 Regulation of AKT1 52 0.56 32.53 4.89
48 INT137336 Phosphorylation of Eif2ak3 14 0.79 4.72 4.78
49 INT116748 Positive_regulation of Gene_expression of Pik3r1 18 0.49 9.83 4.63
50 INT134657 Localization of Akt1 37 0.68 11.58 4.62
51 INT14557 Negative_regulation of Igf1 96 0.59 54.83 4.45
52 INT122569 Negative_regulation of Gene_expression of Akt1 34 0.54 17.15 4.44
53 INT116747 Regulation of Pik3r1 18 0.60 9.33 4.34
54 INT49360 Localization of Igf1 22 0.76 6.96 4.26
55 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21
56 INT75136 Binding of Akt1 27 0.27 8.81 4.15
57 INT230796 Phosphorylation of Irs1 70 0.81 31.73 4.13
58 INT95512 Transcription of Ghr 24 0.69 3.1 4.12
59 INT139898 Negative_regulation of Positive_regulation of Akt1 15 0.42 4.66 4.06
60 INT5602 Positive_regulation of Eif2ak3 9 0.66 0 4.04
61 INT142174 Regulation of Gene_expression of Igf1 28 0.60 11.86 3.77
62 INT132223 Negative_regulation of Negative_regulation of Akt1 6 0.42 2.75 3.66
63 INT136692 Localization of Akt1 12 0.78 2.14 3.65
64 INT207570 Phosphorylation of IRS1 45 0.71 33.27 3.42
65 INT106341 Phosphorylation of Irs1 18 0.72 14.7 3.3
66 INT157687 Regulation of Gene_expression of Akt1 9 0.62 4.96 3.27
67 INT105537 Regulation of Gene_expression of Igf1 15 0.58 6.97 3.23
68 INT165911 Localization of Pik3r1 15 0.51 7.94 3.2
69 INT108203 Negative_regulation of Gene_expression of AKT1 28 0.54 16.38 3.19
70 INT117720 Negative_regulation of Gene_expression of Akt1 11 0.37 2.33 3.08
71 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02
72 INT59905 Gene_expression of Ghr 29 0.63 9.25 2.97
73 INT106340 Positive_regulation of Phosphorylation of Irs1 8 0.53 7.03 2.85
74 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8
75 INT117715 Regulation of Phosphorylation of Akt1 15 0.51 3.23 2.78
76 INT214355 Binding of Akt1 13 0.36 3.72 2.59
77 INT203819 Binding of Eif2ak3 9 0.37 5.94 2.57
78 INT15695 Positive_regulation of EIF2AK3 12 0.67 7.01 2.56
79 INT139735 Positive_regulation of Transcription of Igf1 4 0.53 1.93 2.49
80 INT66544 Binding of Igf1 23 0.46 8.33 2.44
81 INT22019 Regulation of GHR 9 0.62 2.56 2.39
82 INT109305 Phosphorylation of Pik3r1 13 0.53 5.69 2.32
83 INT16286 Positive_regulation of GHR 8 0.60 4.04 2.31
84 INT67352 Transcription of Ghr 8 0.61 1.55 2.3
85 INT59818 Negative_regulation of PLCB1 7 0.57 2.24 2.28
86 INT118791 Binding of AKT1 32 0.48 15.51 2.25
87 INT138286 Regulation of Positive_regulation of Akt1 13 0.45 4.93 2.22
88 INT36758 Positive_regulation of Gene_expression of Eif2ak3 1 0.48 0 2.21
89 INT147417 Positive_regulation of Gene_expression of Igf1r 3 0.46 1.69 2.2
90 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14
91 INT114421 Positive_regulation of Positive_regulation of Pik3r1 9 0.49 4.07 2.13
92 INT95510 Regulation of Ghr 1 0.45 0.21 2.07
93 INT237322 Gene_expression of Irs1 52 0.77 21.07 2
94 INT4643 Negative_regulation of GHR 10 0.45 3.01 2
95 INT36755 Positive_regulation of Localization of Eif2ak3 1 0.48 0 1.97
96 INT36756 Localization of Eif2ak3 1 0.71 0 1.96
97 INT156666 Positive_regulation of Localization of Igf1 11 0.62 6.94 1.95
98 INT142341 Positive_regulation of Transcription of Igf1 8 0.49 2.44 1.95
99 INT150675 Regulation of Gene_expression of Eif2ak3 3 0.40 1.11 1.93
100 INT9336 Negative_regulation of Gene_expression of Igf1r 4 0.42 3.53 1.92
101 INT123130 Positive_regulation of Positive_regulation of AKT1 22 0.49 11.77 1.83
102 INT142236 Regulation of Phosphorylation of Akt1 13 0.61 5.02 1.75
103 INT36759 Regulation of Gene_expression of Eif2ak3 1 0.59 0 1.74
104 INT165332 Negative_regulation of Negative_regulation of Akt1 5 0.42 3.27 1.7
105 INT75316 Gene_expression of Ghr 6 0.78 1.24 1.68
106 INT230799 Positive_regulation of Phosphorylation of Irs1 28 0.69 11.17 1.63
107 INT117714 Regulation of Positive_regulation of Akt1 3 0.61 0.44 1.61
108 INT109033 Positive_regulation of Positive_regulation of Eif2ak3 2 0.45 2.36 1.59
109 INT240031 Positive_regulation of Phosphorylation of IRS1 15 0.46 13.17 1.53
110 INT28300 Gene_expression of GHR 10 0.78 4.29 1.5
111 INT49361 Regulation of Positive_regulation of Igf1 2 0.45 2.15 1.49
112 INT150677 Negative_regulation of Eif2ak3 9 0.58 6.24 1.46
113 INT67348 Negative_regulation of Ghr 8 0.40 2.84 1.43
114 INT135959 Negative_regulation of Gene_expression of Igf1 37 0.56 21.16 1.41
115 INT49128 Gene_expression of IGF1R 35 0.63 23.48 1.39
116 INT109301 Positive_regulation of Phosphorylation of Pik3r1 5 0.42 1.45 1.38
117 INT90491 Binding of Igf1 25 0.44 9.75 1.36
118 INT215864 Localization of Eif2ak3 5 0.75 3.26 1.36
119 INT18337 Transcription of Eif2ak3 3 0.68 0 1.36
120 INT75315 Regulation of Ghr 4 0.22 1.5 1.34
121 INT240842 Positive_regulation of Gene_expression of Irs1 31 0.69 12 1.31
122 INT120970 Negative_regulation of Irs1 12 0.37 8.65 1.28
123 INT210399 Gene_expression of IGF2R 22 0.65 17.1 1.23
124 INT167409 Regulation of Gene_expression of AKT1 8 0.56 4.86 1.23
125 INT9323 Transcription of Igf1r 2 0.63 1.08 1.23
126 INT127900 Phosphorylation of EIF2AK3 14 0.80 7.99 1.22
127 INT59815 Positive_regulation of PLCB1 9 0.67 1.12 1.22
128 INT135556 Localization of AKT1 38 0.69 12.78 1.17
129 INT142616 Negative_regulation of Positive_regulation of Igf1 5 0.43 1.56 1.16
130 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15
131 INT95511 Negative_regulation of Transcription of Ghr 1 0.43 0 1.15
132 INT176147 Regulation of Phosphorylation of AKT1 14 0.41 6.41 1.13
133 INT207203 Transcription of Akt1 6 0.67 3.73 1.1
134 INT61512 Regulation of Binding of GHR 2 0.05 0.89 1.1
135 INT147416 Positive_regulation of Transcription of Igf1r 1 0.46 0.72 1.1
136 INT147415 Positive_regulation of Igf1r 2 0.43 0.97 1.09
137 INT137338 Regulation of Eif2ak3 8 0.45 5.5 1.07
138 INT191050 Positive_regulation of Negative_regulation of Akt1 6 0.31 1.82 1.03
139 INT145864 Gene_expression of Irs1 5 0.71 3.34 1.01
140 INT95514 Negative_regulation of Ghr 3 0.36 1.3 0.99
141 INT134660 Positive_regulation of Localization of Akt1 10 0.32 6.33 0.94
142 INT163508 Regulation of Gene_expression of Akt1 3 0.45 1.65 0.92
143 INT95507 Negative_regulation of Gene_expression of Ghr 3 0.33 0.49 0.91
144 INT139449 Negative_regulation of IGF2R 5 0.15 2.58 0.87
145 INT240368 Positive_regulation of Localization of Eif2ak3 1 0.34 0.66 0.87
146 INT240849 Negative_regulation of Phosphorylation of Irs1 11 0.43 4.74 0.85
147 INT216456 Positive_regulation of Ghr 6 0.41 4.96 0.85
148 INT109032 Negative_regulation of Positive_regulation of Eif2ak3 1 0.38 0.94 0.85
149 INT89407 Positive_regulation of IRS1 10 0.51 9.67 0.81
150 INT224958 Negative_regulation of Transcription of Igf1 5 0.56 1.37 0.81
151 INT288191 Positive_regulation of Localization of Pik3r1 4 0.15 1.27 0.81
152 INT127899 Gene_expression of EIF2AK3 8 0.75 2.89 0.8
153 INT154053 Negative_regulation of Gene_expression of Eif2ak3 2 0.43 1.28 0.79
154 INT114714 Binding of IGF1R 8 0.36 5.26 0.78
155 INT127901 Positive_regulation of Gene_expression of EIF2AK3 3 0.49 1.8 0.77
156 INT245584 Positive_regulation of Gene_expression of Ghr 5 0.41 3.46 0.75
157 INT321433 Negative_regulation of IRS1 3 0.32 5.41 0.75
158 INT151170 Regulation of Regulation of Akt1 2 0.45 3.28 0.73
159 INT73783 Regulation of Gene_expression of GHR 1 0.45 0 0.7
160 INT299338 Negative_regulation of Regulation of AKT1 2 0.31 2.32 0.68
161 INT280678 Transcription of Irs1 1 0.45 0.87 0.68
162 INT252054 Phosphorylation of TSC2 4 0.80 0.63 0.67
163 INT127898 Positive_regulation of Phosphorylation of EIF2AK3 3 0.49 2.03 0.67
164 INT207204 Regulation of Transcription of Akt1 3 0.35 1.41 0.66
165 INT242655 Binding of Irs1 1 0.29 1.45 0.66
166 INT59817 Gene_expression of PLCB1 4 0.75 0.73 0.65
167 INT166024 Protein_catabolism of AKT1 5 0.46 2.6 0.64
168 INT166456 Negative_regulation of Gene_expression of Pik3r1 4 0.41 1.72 0.64
169 INT281466 Negative_regulation of Regulation of Akt1 1 0.33 0.31 0.63
170 INT135666 Negative_regulation of Negative_regulation of Pik3r1 2 0.29 0.3 0.6
171 INT95506 Negative_regulation of Transcription of Ghr 1 0.15 0 0.6
172 INT284334 Gene_expression of IRS1 10 0.49 5.81 0.59
173 INT106343 Positive_regulation of Positive_regulation of Igf1 2 0.69 1.45 0.59
174 INT123131 Negative_regulation of Negative_regulation of AKT1 6 0.42 3.23 0.58
175 INT115255 Negative_regulation of Phosphorylation of Irs1 6 0.45 3.71 0.56
176 INT220365 Negative_regulation of Transcription of Igf1 3 0.45 1.28 0.56
177 INT95508 Negative_regulation of Gene_expression of Ghr 1 0.59 0 0.56
178 INT246832 Positive_regulation of Irs1 16 0.69 7.33 0.55
179 INT145859 Regulation of Gene_expression of Igf1r 1 0.59 1.58 0.55
180 INT49362 Positive_regulation of Localization of Igf1 4 0.65 2.26 0.53
181 INT218900 Regulation of Negative_regulation of Akt1 3 0.15 1.73 0.53
182 INT5601 Regulation of Eif2ak3 1 0.43 0 0.53
183 INT321417 Positive_regulation of Negative_regulation of IRS1 1 0.12 3.82 0.51
184 INT185513 Phosphorylation of Igf1 3 0.67 0.46 0.5
185 INT158517 Regulation of Irs1 2 0.39 1.02 0.5
186 INT276189 Regulation of Localization of Akt1 1 0.43 0.2 0.5
187 INT18336 Positive_regulation of Positive_regulation of Eif2ak3 1 0.33 0 0.49
188 INT157955 Phosphorylation of PLCB1 1 0.01 0.46 0.46
189 INT140942 Regulation of Transcription of Igf1 3 0.32 1.37 0.43
190 INT246828 Binding of Irs1 9 0.37 2.68 0.42
191 INT235635 Negative_regulation of Phosphorylation of IRS1 7 0.37 3.78 0.42
192 INT173752 Positive_regulation of Ghr 3 0.57 2.21 0.41
193 INT145861 Regulation of Gene_expression of Irs1 2 0.41 0.83 0.41
194 INT145863 Negative_regulation of Gene_expression of Irs1 3 0.45 1.51 0.4
195 INT82331 Positive_regulation of Positive_regulation of GHR 1 0.00 0.06 0.4
196 INT15696 Regulation of EIF2AK3 2 0.26 1.1 0.39
197 INT168940 Phosphorylation of Igf1r 1 0.77 2.18 0.38
198 INT139450 Binding of IGF2R 3 0.19 1.75 0.36
199 INT261774 Positive_regulation of Phosphorylation of Igf1 1 0.08 0.09 0.36
200 INT168766 Positive_regulation of Binding of Pik3r1 3 0.21 1.54 0.35
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